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2. Multicentric Longitudinal Prospective Study in a European Cohort of MYO7A Patients: Disease Course and Implications for Gene Therapy

Author

Testa, F, Carreño, E, van den Born, L, Melillo, P, Perea-Romero, I, Di Iorio, V, Risca, G, Iodice, C, Pennings, R, Karali, M, Banfi, S, Auricchio, A, Galimberti, S, Ayuso, C, Simonelli, F, Testa, Francesco, Carreño, Ester, van den Born, L. Ingeborgh, Melillo, Paolo, Perea-Romero, Irene, Di Iorio, Valentina, Risca, Giulia, Iodice, Clemente Maria, Pennings, Ronald J. E., Karali, Marianthi, Banfi, Sandro, Auricchio, Alberto, Galimberti, Stefania, Ayuso, Carmen, Simonelli, Francesca, Testa, F, Carreño, E, van den Born, L, Melillo, P, Perea-Romero, I, Di Iorio, V, Risca, G, Iodice, C, Pennings, R, Karali, M, Banfi, S, Auricchio, A, Galimberti, S, Ayuso, C, Simonelli, F, Testa, Francesco, Carreño, Ester, van den Born, L. Ingeborgh, Melillo, Paolo, Perea-Romero, Irene, Di Iorio, Valentina, Risca, Giulia, Iodice, Clemente Maria, Pennings, Ronald J. E., Karali, Marianthi, Banfi, Sandro, Auricchio, Alberto, Galimberti, Stefania, Ayuso, Carmen, and Simonelli, Francesca

Published
2024

3. Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B

Author

Ferla, R, Dell'Aquila, F, Doria, M, Ferraiuolo, M, Noto, A, Grazioli, F, Ammendola, V, Testa, F, Melillo, P, Iodice, C, Risca, G, Tedesco, N, le Brun, P, Surace, E, Simonelli, F, Galimberti, S, Valsecchi, M, Marteau, J, Veron, P, Colloca, S, Auricchio, A, Ferla R., Dell'Aquila F., Doria M., Ferraiuolo M., Noto A., Grazioli F., Ammendola V., Testa F., Melillo P., Iodice C., Risca G., Tedesco N., le Brun P. R., Surace E. M., Simonelli F., Galimberti S., Valsecchi M. G., Marteau J. B., Veron P., Colloca S., Auricchio A., Ferla, R, Dell'Aquila, F, Doria, M, Ferraiuolo, M, Noto, A, Grazioli, F, Ammendola, V, Testa, F, Melillo, P, Iodice, C, Risca, G, Tedesco, N, le Brun, P, Surace, E, Simonelli, F, Galimberti, S, Valsecchi, M, Marteau, J, Veron, P, Colloca, S, Auricchio, A, Ferla R., Dell'Aquila F., Doria M., Ferraiuolo M., Noto A., Grazioli F., Ammendola V., Testa F., Melillo P., Iodice C., Risca G., Tedesco N., le Brun P. R., Surace E. M., Simonelli F., Galimberti S., Valsecchi M. G., Marteau J. B., Veron P., Colloca S., and Auricchio A.

Abstract

Gene therapy of Usher syndrome type 1B (USH1B) due to mutations in the large Myosin VIIA (MYO7A) gene is limited by the packaging capacity of adeno-associated viral (AAV) vectors. To overcome this, we have previously developed dual AAV8 vectors which encode human MYO7A (dual AAV8.MYO7A). Here we show that subretinal administration of 1.37E+9 to 1.37E+10 genome copies of a good-manufacturing-practice-like lot of dual AAV8.MYO7A improves the retinal defects of a mouse model of USH1B. The same lot was used in non-human primates at doses 1.6× and 4.3× the highest dose proposed for the clinical trial which was based on mouse efficacy data. Long-lasting alterations in retinal function and morphology were observed following subretinal administration of dual AAV8.MYO7A at the high dose. These findings were modest and improved over time in the low-dose group, as also observed in other studies involving the use of AAV8 in non-human primates and humans. Biodistribution and shedding studies confirmed the presence of vector DNA mainly in the visual pathway. Accordingly, we detected human MYO7A mRNA expression predominantly in the retina. Overall, these studies pave the way for the clinical translation of subretinal administration of dual AAV vectors in USH1B subjects.

Published
2023

5. A closed-form solution for the failure interaction diagrams of pile groups subjected to inclined eccentric load

Author

Di Laora R., Iodice C., Mandolini A., Di Laora, R., Iodice, C., and Mandolini, A.

Subjects
Bearing capacity, Eccentric load, Inclined load, Earth and Planetary Sciences (miscellaneous), Pile group, Ultimate Limit State, Geotechnical Engineering and Engineering Geology
Abstract

The work at hand proposes a method for assessing, under reasonable hypotheses from an engineering perspective, the failure envelope of a pile group subjected to generalized loading conditions involving a vertical and a lateral force along with a moment. Following different assumptions of increasing complexity, a simple closed-form expression, which is however capable of considering also the strong dependence of sectional yielding moment on the axial force, is derived. The use of such formula, which allows a practical hand calculation of the interaction diagrams at failure, returns conservative yet very accurate results. As a follow up, with reference to reinforced concrete piles, design considerations involving both structural and geotechnical failure under lateral load are reported. It is found that for most cases, if steel reinforcement is established to resist the design bending moment, the geotechnical Ultimate Limit State checks are automatically satisfied.

Published
2022
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6. Numerical analysis of energy piles in a hypoplastic soft clay under cyclic thermal loading

Author

Iodice, C, Di Laora, R, Tamagnini, C, Viggiani, GMB, Mandolini, A, Iodice, C [0000-0003-2116-1930], Di Laora, R [0000-0002-9993-5353], and Apollo - University of Cambridge Repository

Subjects
Mechanics of Materials, constitutive modelling, cyclic loading, FE analysis, thermal piles, volumetric collapse, Computational Mechanics, constitutive modelling, volumetric collapse, General Materials Science, thermal piles, Geotechnical Engineering and Engineering Geology, FE analysis, cyclic loading
Abstract

This work is a numerical investigation of the effect of thermally induced volumetric collapse of normally consolidated clays on the performance of energy piles. A series of coupled thermo‐hydro‐mechanical Finite Element simulations were carried out using the commercial software ABAQUS. These examined a single free‐head energy pile embedded in a normally consolidated clay layer subjected to a constant mechanical load and to a number of heating/cooling cycles, to reproduce operating conditions. The soil behaviour was described with two advanced hypoplastic constitutive models for clays, one of which incorporates the thermally induced volumetric collapse using an ad‐hoc algorithm developed by the authors. Both models predict a cyclic accumulation of settlement and excess pore water pressure, especially when the thermal collapse effect is considered. While the excess pore pressure distribution stabilises within a few cycles, the rate of settlement of the pile head does not show any tendency to decrease from one cycle to another. These results are in agreement with data from small scale tests on an isolated energy pile in normally consolidated clay, indicating that the numerical model developed in this study can be used to investigate the complex soil/pile/raft interaction processes occurring in real piled foundations incorporating energy piles.

Published
2023

7. Risk of end-stage kidney disease in kidney transplant recipients versus patients with native chronic kidney disease: multicentre unmatched and propensity-score matched analyses

Author

De Nicola, L., Serra, R., Provenzano, M., Minutolo, R., Michael, A., Ielapi, N., Federico, S., Carrano, R., Bellizzi, V., Garofalo, C., Iodice, C., Borrelli, S., Grandaliano, Giuseppe, Stallone, G., Gesualdo, L., Chiodini, P., Andreucci, M., Grandaliano G. (ORCID:0000-0003-1213-2177), De Nicola, L., Serra, R., Provenzano, M., Minutolo, R., Michael, A., Ielapi, N., Federico, S., Carrano, R., Bellizzi, V., Garofalo, C., Iodice, C., Borrelli, S., Grandaliano, Giuseppe, Stallone, G., Gesualdo, L., Chiodini, P., Andreucci, M., and Grandaliano G. (ORCID:0000-0003-1213-2177)

Abstract

Background: In kidney transplant recipients (KTR), the end-stage kidney disease (ESKD) risk dependent on the risk factors acting in native chronic kidney disease (CKD) remains undefined. Methods: We compared risk and determinants of ESKD between 757 adult KTR and 1940 patients with native CKD before and after propensity-score (PS) analysis matched for unmodifiable risk factors [(age, sex, diabetes, cardiovascular disease and estimated glomerular filtration rate (eGFR)]. Results: In unmatched cohorts, eGFR was lower in CKD versus KTR (45.9 ± 11.3 versus 59.2 ± 13.4 mL/min/1.73 m2, P < 0.001). During a median follow-up of 5.4 years, the unadjusted cumulative incidence of ESKD was consistently lower in unmatched KTR versus CKD. Conversely, in PS-matched analysis, the risk of ESKD in KTR was 78% lower versus CKD at 1 year of follow-up while progressively increased over time resulting similar to that of native CKD patients after 5 years and 2.3-fold higher than that observed in CKD at 10 years. R2 analysis in unmatched patients showed that the proportion of the outcome variance explained by traditional ESKD determinants was smaller in KTR versus native CKD (31% versus 70%). After PS matching, the risk of ESKD [hazard ratio (HR), 95% confidence interval (95% CI)] was significantly associated with systolic blood pressure (1.02, 1.01-1.02), phosphorus (1.31, 1.05-1.64), 24-h proteinuria (1.11, 1.05-1.17) and haemoglobin (0.85, 0.78-0.93) irrespective of KTR status. Similar data were obtained after matching also for modifiable risk factors. Conclusions: In KTR, when compared with matched native CKD patients, the risk of ESKD is lower in the first 5 years and higher later on. Traditional determinants of ESKD account for one-third of the variability of time-to-graft failure.

Published
2023

10. New Insight into Marine Biotechnology: Carrageenans Chemical Features and Acetylcholinesterase (AChE) Inhibition Activity of Two Edible Seaweeds of the Genus Kappaphycus

Author

Olanrewaju O.S., Tommonaro G., Guerriero G., Fogliano C., Iodice C., Velotto G., and Tramice A.

Subjects
Kappaphycus sp, Acetylcholinesterase (AChE) inhibition, Carragenan, Nuclear magnetic resonance (NMR)
Abstract

The red seaweed, Kappaphycus sp. is cultivated extensively as a source of carrageenans which have been used for decades in food applications and are generally regarded as safe. A deep chemical investigation has been performed on carrageenans from two species of Kappaphycus, K. alvarezii and K. striatum, by means of NMR spectroscopy technique. The NMR spectra study suggested the presence for both samples of a mixture of prevailing ?- and ?-carrageenans. Results confirmed that NMR spectroscopy represents actually the preferred technique to determine and quantify the composition of carrageenan from different algae sources. Moreover, the acetylcholinesterase (AChE) inhibition activity of different extracts of K. alvarezii and K. striatus has have been evaluated by using two different assays, thin layer chromatography (TLC) assay with Fast Blue B salt as a reagent and a multiwell plate assay based on Ellman's method. Chloroform/methanol extracts of both samples showed the best AChE inhibition activity starting from 0.01 mg ml.

Published
2021
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12. [Ultrasonography in chronic lithium nephropathy: a case report]

Author

Iodice, C., Garofalo, C., Silvio Borrelli, Conte, G., Nicola, L., Minutolo, R., Di Cerbo, A., Provenzano, M., Nappi, F., Iodice, Carmela, Garofalo, Carlo, Borrelli, Silvio, Conte, Giuseppe, De Nicola, Luca, Minutolo, Roberto, Di Cerbo, Arcangelo, Provenzano, Michele, and Nappi, Felice

Subjects
Adult, lithium, Insipid Nephrogenic Diabete, renal ultrasound, Lithium Compounds, nephropathy, Humans, polyuria, Female, Renal Insufficiency, Chronic, Ultrasonography
Abstract

Lithium has always been used as a first-choice therapy in bipolar disorders. However, its therapeutic index is restricted by placing patients at risk of potential nephrotoxic effects ranging from polyuria, to Insipid Nephrogenic Diabetes, to chronic kidney disease with a slow reduction of renal function over time. The Nephrologist has the role to diagnose chronic lithium nephropathy, monitoring its evolution and optimizing the management of risks associated with the treatment. In fact, the main objective, to be shared with the psychiatrist, is to encourage the maintenance of therapy even in the presence of nephropathy. Renal ultrasound, a safe, repeatable and low-cost technique, is essential to pursue this goal as it not only confirms the diagnosis of chronic lithium nephropathy hypothesized on the basis of the history and clinical picture, but is also helpful in monitoring its evolution. In this paper, we report a case of chronic lithium nephropathy in order to analyze the etiopathogenesis of renal damage, the clinical-laboratory and histological picture and, in particular, the fundamental role of ultrasound imaging.

Published
2019

13. High-throughput screening identifies kinase inhibitors that increase dual AAV vectors transduction in vitro and in mouse retina

Author

Maddalena A, Dell’Aquila F, Giovannelli P, Tiberi P, Wanderlingh LG, Montefusco S, Iodice C, Visconte F, Carissimo A, Medina DL, Castoria G, Auricchio A., Maddalena, A, Dell’Aquila, F, Giovannelli, P, Tiberi, P, Wanderlingh, Lg, Montefusco, S, Iodice, C, Visconte, F, Carissimo, A, Medina, Dl, Castoria, G, and Auricchio, A.

Subjects
viruses, Vectors , AAV, Disease Models, Eye, Dual AAV, Kinase inhibitors, Retina
Abstract

Retinal gene therapy based on adeno-associated viral (AAV) vectors is safe and efficient in humans. The low intrinsic DNA transfer capacity of AAV has been expanded by dual vectors where a large expression cassette is split in two halves independently packaged in two AAV vectors. Dual AAV transduction efficiency, however, is greatly reduced compared to that obtained with a single vector. As AAV intracellular trafficking and processing are negatively affected by phosphorylation, we set to identify kinase inhibitors that can increase dual AAV vector transduction. By high throughput screening of a kinase inhibitors library, we identified 3 compounds that increase AAV transduction in vitro, one of which has higher effect on dual than on single AAV vectors. Importantly, the transduction enhancement is exerted on various AAV serotypes and is not transgene-dependent. As kinase inhibitors are promiscuous, we performed siRNA-mediated silencing of targeted kinases and identified AURKA and B, PLK1 and PTK2 among those involved in the increase of AAV transduction levels, and we show that kinase inhibitors administration reduces AAV2 capsid phosphorylation and increases the activity of DNA-repair pathways involved in AAV DNA processing. Importantly, the kinase inhibitor PF-00562271 improves dual AAV8 transduction in photoreceptors following subretinal delivery in mice. Our study identifies kinase inhibitors that increase dual and single AAV transduction by modulating AAV entry and post-entry steps.

Published
2018

14. Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial

Author

Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., Agrusta M., Vaccaro, O, Masulli, M, Nicolucci, A, Bonora, E, Del Prato, S, Maggioni, A, Rivellese, A, Squatrito, S, Giorda, C, Sesti, G, Mocarelli, P, Lucisano, G, Sacco, M, Signorini, S, Cappellini, F, Perriello, G, Babini, A, Lapolla, A, Gregori, G, Giordano, C, Corsi, L, Buzzetti, R, Clemente, G, Di Cianni, G, Iannarelli, R, Cordera, R, La Macchia, O, Zamboni, C, Scaranna, C, Boemi, M, Iovine, C, Lauro, D, Leotta, S, Dall'Aglio, E, Cannarsa, E, Tonutti, L, Pugliese, G, Bossi, A, Anichini, R, Dotta, F, Di Benedetto, A, Citro, G, Antenucci, D, Ricci, L, Giorgino, F, Santini, C, Gnasso, A, De Cosmo, S, Zavaroni, D, Vedovato, M, Consoli, A, Calabrese, M, di Bartolo, P, Fornengo, P, Riccardi, G, D'Angelo, F, Giansanti, R, Tanase, L, Lanari, L, Testa, I, Pancani, F, Ranchelli, A, Vagheggi, P, Scatona, A, Fontana, L, Laviola, L, Tarantino, L, Ippolito, C, Gigantelli, V, Manicone, M, Conte, E, Trevisan, R, Rota, R, Dodesini, A, Reggiani, G, Montesi, L, Mazzella, N, Forlani, G, Caselli, C, Di Luzio, R, Mazzotti, A, Aiello, A, Barrea, A, Musto, A, D'Amico, F, Sinagra, T, Longhitano, S, Trowpea, V, Sparti, M, Italia, S, Lisi, E, Grasso, G, Pezzino, V, Insalaco, F, Carallo, C, Scicchitano, C, De Franceschi, M, Calbucci, G, Ripani, R, Cuneo, G, Corsi, S, Romeo, F, Lesina, A, Comoglio, M, Bonetto, C, Robusto, A, Nada, E, Asprino, V, Cetraro, R, Impieri, M, Lucchese, G, Donnarumma, G, Tizio, B, Lenza, L, Paraggio, P, Tomasi, F, Dozio, N, Scalambra, E, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, O, Fariello, S, Sorrentino, M, Franzetti, I, Radin, R, Annunziata, F, Bonabello, L, Durante, A, Dolcino, M, Gallo, F, Mazzucchelli, C, Aleo, A, Melga, P, Briatore, L, Maggi, D, Storace, D, Cecoli, F, D'Ugo, E, Pupillo, M, Baldassarre, M, Salvati, F, Minnucci, A, De Luca, A, Zugaro, A, Santarelli, L, Bosco, A, Petrella, V, La Verghetta, G, D'Andrea, S, Giuliani, A, Polidoro, W, Sperandio, A, Sciarretta, F, Pezzella, A, Carlone, A, Potenziani, S, Venditti, C, Foffi, C, Carbone, S, Cipolloni, L, Moretti, C, Leto, G, Serra, R, Petrachi, F, Romano, I, Lacaria, E, Russo, L, Goretti, C, Sannino, C, Dolci, M, Bruselli, L, Mori, M, Baccetti, F, Del Freo, M, Cucinotta, D, Giunta, L, Ruffo, M, Cannizzaro, D, Pintaudi, B, Perrone, G, Pata, P, Ragonese, F, Lettina, G, Mancuso, T, Coppolino, A, Piatti, P, Monti, L, Stuccillo, M, Lucotti, P, Setola, M, Crippa, G, Loi, C, Oldani, M, Bottalico, M, Pellegata, B, Bonomo, M, Menicatti, L, Resi, V, Bertuzzi, F, Disoteo, E, Pizzi, G, Annuzzi, G, Capaldo, B, Nappo, R, Auciello, S, Turco, A, Costagliola, L, Corte, G, Vallefuoco, P, Nappi, F, Vitale, M, Cocozza, S, Ciano, O, Massimino, E, Garofalo, N, Avogaro, A, Guarneri, G, Fedele, D, Sartore, G, Chilelli, N, Burlina, S, Bonsembiante, B, Galluzzo, A, Torregrossa, V, Mancastroppa, G, Arsenio, L, Cioni, F, Caronna, S, Papi, M, Santeusanio, F, Calagreti, G, Timi, A, Tantucci, A, Marino, C, Ginestra, F, Di Biagio, R, Taraborelli, M, Miccoli, R, Bianchi, C, Garofolo, M, Politi, K, Penno, G, Livraga, S, Calzoni, F, Corsini, E, Tedeschi, A, Gagliano, M, Ippolito, G, Salutini, E, Cervellino, F, Natale, M, Salvatore, V, Zampino, A, Sinisi, R, Arcangeli, A, Zogheri, A, Guizzotti, S, Longo, R, Pellicano, F, Scolozzi, P, Termine, S, Luberto, A, Ballardini, G, Trojani, C, Mazzuca, P, Bruglia, M, Ciamei, M, Genghini, S, Zannoni, C, Rangel, G, Salvi, L, Zappaterreno, A, Cordone, S, Simonelli, P, Meggiorini, M, Frasheri, A, Di Pippo, C, Maglio, C, Mazzitelli, G, Rinaldi, M, Galli, A, Romano, M, D'Angelo, P, Suraci, C, Bacci, S, Palena, A, Genovese, S, Mancino, M, Rondinelli, M, Capone, F, Calabretto, E, Bulgheroni, M, Bucciarelli, L, Ceccarelli, E, Fondelli, C, Santacroce, C, Guarino, E, Nigi, L, Lalli, C, Di Vizia, G, Scarponi, M, Montani, V, Di Bernardino, P, Romagni, P, Dolcetti, K, Forte, E, Tamburo, L, Perin, P, Prinzis, T, Gruden, G, Bruno, G, Zucco, C, Perotta, M, Marena, S, Monsignore, S, Panero, F, Ponzi, F, Carpinteri, R, Casagrande, M, Coletti, M, Balini, A, Filopanti, M, Madaschi, S, Pulcina, A, Grimaldi, F, Venturini, G, Agus, S, Pagnutti, S, Guidotti, F, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Fainelli, G, Tomasetto, E, Zoppini, G, Galletti, A, Perrone, D, Capra, C, Bianchini, F, Ceseri, M, Di Nardo, B, Sasso, E, Bartolomei, B, Suliman, I, Fabbri, G, Romano, G, Maturo, N, Nunziata, G, Capobianco, G, De Simone, G, Villa, V, Rota, G, Pentangelo, C, Carbonara, O, Caiazzo, G, Cutolo, M, Sorrentino, T, Mastrilli, V, Amelia, U, Masi, S, Corigliano, G, Gaeta, I, Armentano, V, Calatola, P, Capuano, G, Angiulli, B, Auletta, P, Petraroli, E, Iodice, C, Agrusta, M, Vaccaro O., Masulli M., Nicolucci A., Bonora E., Del Prato S., Maggioni A. P., Rivellese A. A., Squatrito S., Giorda C. B., Sesti G., Mocarelli P., Lucisano G., Sacco M., Signorini S., Cappellini F., Perriello G., Babini A. C., Lapolla A., Gregori G., Giordano C., Corsi L., Buzzetti R., Clemente G., Di Cianni G., Iannarelli R., Cordera R., La Macchia O., Zamboni C., Scaranna C., Boemi M., Iovine C., Lauro D., Leotta S., Dall'Aglio E., Cannarsa E., Tonutti L., Pugliese G., Bossi A. C., Anichini R., Dotta F., Di Benedetto A., Citro G., Antenucci D., Ricci L., Giorgino F., Santini C., Gnasso A., De Cosmo S., Zavaroni D., Vedovato M., Consoli A., Calabrese M., di Bartolo P., Fornengo P., Riccardi G., D'Angelo F., Giansanti R., Tanase L., Lanari L., Testa I., Pancani F., Ranchelli A., Vagheggi P., Scatona A., Fontana L., Laviola L., Tarantino L., Ippolito C., Gigantelli V., Manicone M., Conte E., Trevisan R., Rota R., Dodesini A. R., Reggiani G. M., Montesi L., Mazzella N., Forlani G., Caselli C., Di Luzio R., Mazzotti A., Aiello A., Barrea A., Musto A., D'Amico F., Sinagra T., Longhitano S., Trowpea V., Sparti M., Italia S., Lisi E., Grasso G., Pezzino V., Insalaco F., Carallo C., Scicchitano C., De Franceschi M. S., Calbucci G., Ripani R., Cuneo G., Corsi S., Romeo F., Lesina A., Comoglio M., Bonetto C., Robusto A., Nada E., Asprino V., Cetraro R., Impieri M., Lucchese G., Donnarumma G., Tizio B., Lenza L., Paraggio P., Tomasi F., Dozio N., Scalambra E., Mannucci E., Lamanna C., Cignarelli M., Macchia O. L., Fariello S., Sorrentino M. R., Franzetti I., Radin R., Annunziata F., Bonabello L. A., Durante A., Dolcino M., Gallo F., Mazzucchelli C., Aleo A., Melga P., Briatore L., Maggi D., Storace D., Cecoli F., D'Ugo E., Pupillo M., Baldassarre M. P. A., Salvati F., Minnucci A., De Luca A., Zugaro A., Santarelli L., Bosco A., Petrella V., La Verghetta G. G., D'Andrea S., Giuliani A. E., Polidoro W. L., Sperandio A., Sciarretta F., Pezzella A., Carlone A., Potenziani S., Venditti C., Foffi C., Carbone S., Cipolloni L., Moretti C., Leto G., Serra R., Petrachi F., Romano I., Lacaria E., Russo L., Goretti C., Sannino C., Dolci M., Bruselli L., Mori M. L., Baccetti F., Del Freo M., Cucinotta D., Giunta L., Ruffo M. C., Cannizzaro D., Pintaudi B., Perrone G., Pata P., Ragonese F., Lettina G., Mancuso T., Coppolino A., Piatti P. M., Monti L., Stuccillo M., Lucotti P., Setola M., Crippa G. V., Loi C., Oldani M., Bottalico M. L., Pellegata B., Bonomo M., Menicatti L. S. M., Resi V., Bertuzzi F., Disoteo E. O., Pizzi G., Annuzzi G., Capaldo B., Nappo R., Auciello S. M., Turco A. A., Costagliola L., Corte G. D., Vallefuoco P., Nappi F., Vitale M., Cocozza S., Ciano O., Massimino E., Garofalo N., Avogaro A., Guarneri G., Fedele D., Sartore G., Chilelli N. C., Burlina S., Bonsembiante B., Galluzzo A., Torregrossa V., Mancastroppa G., Arsenio L., Cioni F., Caronna S., Papi M., Santeusanio F., Calagreti G., Timi A., Tantucci A., Marino C., Ginestra F., Di Biagio R., Taraborelli M., Miccoli R., Bianchi C., Garofolo M., Politi K. S., Penno G., Livraga S., Calzoni F., Mancastroppa G. L. F., Corsini E., Tedeschi A., Gagliano M. S., Ippolito G., Salutini E., Cervellino F., Natale M., Salvatore V., Zampino A., Sinisi R., Arcangeli A., Zogheri A., Guizzotti S., Longo R., Pellicano F., Scolozzi P., Termine S., Luberto A., Ballardini G., Trojani C., Mazzuca P., Bruglia M., Ciamei M., Genghini S., Zannoni C., Rangel G., Salvi L., Zappaterreno A., Cordone S., Simonelli P., Meggiorini M., Frasheri A., Di Pippo C., Maglio C., Mazzitelli G., Rinaldi M. E., Galli A., Romano M., D'Angelo P., Suraci C., Bacci S., Palena A. P., Genovese S., Mancino M., Rondinelli M., Capone F., Calabretto E., Bulgheroni M., Bucciarelli L., Ceccarelli E., Fondelli C., Santacroce C., Guarino E., Nigi L., Lalli C., Di Vizia G., Scarponi M., Montani V., Di Bernardino P., Romagni P., Dolcetti K., Forte E., Tamburo L., Perin P. C., Prinzis T., Gruden G., Bruno G., Zucco C., Perotta M., Marena S., Monsignore S., Panero F., Ponzi F., Carpinteri R., Casagrande M. L., Coletti M. F., Balini A., Filopanti M., Madaschi S., Pulcina A., Grimaldi F., Venturini G., Agus S., Pagnutti S., Guidotti F., Cavarape A., Cigolini M., Pichiri I., Brangani C., Fainelli G., Tomasetto E., Zoppini G., Galletti A., Perrone D., Capra C., Bianchini F., Ceseri M., Di Nardo B., Sasso E., Bartolomei B., Suliman I., Fabbri G., Romano G., Maturo N., Nunziata G., Capobianco G., De Simone G., Villa V., Rota G., Pentangelo C., Carbonara O., Caiazzo G., Cutolo M., Sorrentino T., Mastrilli V., Amelia U., Masi S., Corigliano G., Gaeta I., Armentano V., Calatola P., Capuano G., Angiulli B., Auletta P., Petraroli E., Iodice C. E., and Agrusta M.

Abstract

Background The best treatment option for patients with type 2 diabetes in whom treatment with metformin alone fails to achieve adequate glycaemic control is debated. We aimed to compare the long-term effects of pioglitazone versus sulfonylureas, given in addition to metformin, on cardiovascular events in patients with type 2 diabetes. Methods TOSCA.IT was a multicentre, randomised, pragmatic clinical trial, in which patients aged 50–75 years with type 2 diabetes inadequately controlled with metformin monotherapy (2–3 g per day) were recruited from 57 diabetes clinics in Italy. Patients were randomly assigned (1:1), by permuted blocks randomisation (block size 10), stratified by site and previous cardiovascular events, to add-on pioglitazone (15–45 mg) or a sulfonylurea (5–15 mg glibenclamide, 2–6 mg glimepiride, or 30–120 mg gliclazide, in accordance with local practice). The trial was unblinded, but event adjudicators were unaware of treatment assignment. The primary outcome, assessed with a Cox proportional-hazards model, was a composite of first occurrence of all-cause death, non-fatal myocardial infarction, non-fatal stroke, or urgent coronary revascularisation, assessed in the modified intention-to-treat population (all randomly assigned participants with baseline data available and without any protocol violations in relation to inclusion or exclusion criteria). This study is registered with ClinicalTrials.gov, number NCT00700856. Findings Between Sept 18, 2008, and Jan 15, 2014, 3028 patients were randomly assigned and included in the analyses. 1535 were assigned to pioglitazone and 1493 to sulfonylureas (glibenclamide 24 [2%], glimepiride 723 [48%], gliclazide 745 [50%]). At baseline, 335 (11%) participants had a previous cardiovascular event. The study was stopped early on the basis of a futility analysis after a median follow-up of 57·3 months. The primary outcome occurred in 105 patients (1·5 per 100 person-years) who were given pioglitazone and 108 (1·5 p

Published
2017

18. Trattamento sintomatico della proteinuria

Author

Sorrentino F, Vitiello S, Iodice C, DE NICOLA, Luca, Sonia Pasquali , Dario Roccatello , Antonello Pani, Wichtig Editore, Sorrentino, F, Vitiello, S, Iodice, C, and DE NICOLA, Luca

Published
2013

20. Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration. Blood Purif 2010;30:166-171

Author

BORRELLI S, MINUTOLO, Roberto, DE NICOLA, Luca, ZAMBOLI, Pasquale, IODICE C, DE PAOLA A, DE SIMONE E, ZITO B, GUASTAFERRO P, NIGRO F, APPERTI V, IULIANIELLO G, CREDENDINO O, IACONO G, DI SERAFINO A, D'APICE L, SAVIANO C, SARTI A, CAPUANO M, GENUALDO R, AURICCHIO M, MEROLA M, CONTE, Giuseppe, Borrelli, S, Minutolo, Roberto, DE NICOLA, Luca, Zamboli, Pasquale, Iodice, C, DE PAOLA, A, DE SIMONE, E, Zito, B, Guastaferro, P, Nigro, F, Apperti, V, Iulianiello, G, Credendino, O, Iacono, G, DI SERAFINO, A, D'Apice, L, Saviano, C, Sarti, A, Capuano, M, Genualdo, R, Auricchio, M, Merola, M, and Conte, Giuseppe

Published
2010

21. The Mediterranean Sponge Dysidea avara as a 40 Year Inspiration of Marine Natural Product Chemists

Author

Tommonaro G, Iodice C, Abd El-Hady FK, Guerriero G, and Pejin B

Subjects
Marine sponges, Dysidea avara, Avarol, Bioactivity, Antimicrobial, Cytotoxic activities, Alzheimer's disease, Antipsoriatic
Abstract

Marine sponges have been intensively studied by organic chemists, biologists and pharmacologists during last 60 years, due to great biodiversity of their secondary metabolites. A couple of very promising bioactivities of these compounds have been reported. Indeed, some of these metabolites are considered as the leads for the future drugs targeting tumours, viral and bacterial diseases, malaria and inflammations. Herein we briefly report key bioactivities of avarol, the main secondary metabolite of the marine sponge Dysidea avara (Schmidt, 1862).

Published
2015
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23. Hyponatremia secondary to inappropriate antidiuretic hormone secretion

Author

ZAMBOLI, Pasquale, DE NICOLA, Luca, MINUTOLO, Roberto, Iodice C, Avino D, Mascia S, D'Angiò P, Calabria M, CONTE, Giuseppe, Zamboli, Pasquale, DE NICOLA, Luca, Minutolo, Roberto, Iodice, C, Avino, D, Mascia, S, D'Angiò, P, Calabria, M, and Conte, Giuseppe

Published
2008

24. Gestione dei fattori di rischio cardiovascolare (CV) nella nefropatia diabetica tipo 2 (ND): analisi comparativa tra nefrologia, diabetologia e medicina generale

Author

ZAMBOLI, Pasquale, MINUTOLO, Roberto, Iodice C, Sosio R, Bertino V, Stanzione G, Casoria V, Calabria M, Del Prete A, D’Angiò P, Lampitella A, Pagano A, Lascar N, CONTE, Giuseppe, DE NICOLA, Luca, Sezione Campano-Siciliana della SIN 2006, Zamboli, Pasquale, Minutolo, Roberto, Iodice, C, Sosio, R, Bertino, V, Stanzione, G, Casoria, V, Calabria, M, Del Prete, A, D’Angiò, P, Lampitella, A, Pagano, A, Lascar, N, Conte, Giuseppe, and DE NICOLA, Luca

Published
2006

25. [Daily nutrient intake in hemodialysis]

Author

Bellizzi V, Di Iorio BR, ZAMBOLI, Pasquale, Terracciano V, MINUTOLO, Roberto, Iodice C, DE NICOLA, Luca, CONTE, Giuseppe, Bellizzi, V, Di Iorio, Br, Zamboli, Pasquale, Terracciano, V, Minutolo, Roberto, Iodice, C, DE NICOLA, Luca, and Conte, Giuseppe

Subjects
Male, Renal Dialysis, Humans, Female, Dietary Proteins, Longitudinal Studies, Middle Aged, Energy Intake
Abstract

Although there is a higher nutrient requirement, food intake in haemodialysis patients is often inadequate. Protein nitrogen appearance (PNA) indirectly estimates the mean protein intake during the short interdialysis period, but it does not measure the daily nutrient intake, which is generally unknown. We carried out a longitudinal study aimed at estimating the daily nutrient intake and its relationship with the nutritional status of haemodialysis patients.We selected 28 haemodialysis patients with adequate nutritional status and no evidence of risk-factor for malnutrition. Patients were treated with biocompatible membranes, low-flux and high bicarbonate dialysis, Kt/V1.2, PNA1.1 g/kg/day and erythropoietin. We measured every four months daily PNA, protein and calorie intake (DPI, DCI) as well as weight gain (WG) during an entire week for one-year. The nutritional status was assessed by biochemical and BIA markers.Twenty seven subjects (8 F, 19 M; age 57.1 +- 2.7 yeas; dialysis age 105 +- 13 months) completed the trial. The mean interdialytic PNA did not change in both long- and short-interdialysis periods, resulting in the "normal" range (1.1 g/kg/day); however, daily levels of protein and calorie intake were significantly reduced on the third day during the long interdialysis interval. Eight patients showed time-averaged values of DPI and DCI lower than 0.8 g/kg/day and 25 Kcal/kg/day, respectively, on the third day (LOW group), values that were associated with similar changes in WG. Such a highly reduced nutrient intake during the third interdialysis day was associated with a normal PNA value (1.23 +- 0.05 g/kg/day vs 1.30 +- 0.06 in CON, NS) when measured during the short interdialysis period (S), just as it is in clinical practice; in contrast, when the PNA value was measured during the long interdialysis period it was found to be significantly reduced (1.07 +- 0.08 g/kg/day vs 1.37 +- 0.06 in CON, p0.05 and vs S, p0.05). During the study, the body weight progressively decreased from 68.0 +- 5.5 to 65.8 +- 5.9 kg (p0.05) in the LOW group, due to the decrease in lean body mass, as suggested by the reduction in serum creatinine (9.2 +- 1.1 vs 8.1 +- 0.7 mg/dL, p0.05), creatinine generation (835 +- 155 vs 723 +- 106 mg/die, p0.05) and serum albumin (3.96 +- 0.07 vs 3.66 +- 0.06 g/dL, p0.05). Moreover, reactance and phase angle declined in the LOW group (from 54 +- 4 to 44 +- 3 ohms, p0.05 and 5.5 +- 0.3 to 4.5 +- 0.3 degrees, p0.05, respectively). At the end of the study the nutritional status in the LOW group was reduced as compared to the CON group.In stable, well-nourished haemodialysis patients, in absence of known risk factors for malnutrition, the daily nutrient intake is variable and progressively reduce during the interdialytic interval. The measurement of interdialytic PNA, as is done in clinical practice, does not enable the discovery of such abnormal eating behaviour; the low daily nutrient intake, on the contrary, can be evidenced by the daily measurement of either PNA or weight gain, and it can also be inferred by the reduced PNA during the long interdialytic period. Finally, the persistent reduction in nutrient intake below the threshold of 0.8 g/kg/day of proteins and 25 Kcal/kg/day one day a week, is capable of inducing body protein wasting and moderate impairment of the nutritional status.

Published
2004

26. Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol

Author

Pejin B., Iodice C., Tommonaro G., De Rosa S., Stanimirovic B., Ciric A., Glamoclija J., Nikolic M., and Sokovic M.

Subjects
Dysidea avara, Gram-negative bacteria, Anti-quorum sensing effects, Pseudomonas aeruginosa PAO1, Natural product
Abstract

This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.

Published
2014

27. Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone

Author

Pejin B., Iodice C., Tommonaro G., Bogdanovic G., Kojic V., and De Rosa S.

Abstract

The cytotoxicity of 40-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40mM and 9.62mM, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ERnegativeMDA-MB-231 cells (IC50 11.64mMand 17.31mM, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24mM and 15.54mM, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans

Published
2014

31. Variazioni settimanali dell’ematocrito in pazienti emodializzati: efetto protettivo del refilling plasmatico

Author

CATAPANO F, MAIONE E, ZAMBOLI, Pasquale, AVINO D, AQUARO M, ESPOSITO L, IODICE C, MINUTOLO, Roberto, GIANNATTASIO P, DI IORIO BR, BELLIZZI V, CONTE, Giuseppe, Sezione Campano-Siciliana della SIN, Catapano, F, Maione, E, Zamboli, Pasquale, Avino, D, Aquaro, M, Esposito, L, Iodice, C, Minutolo, Roberto, Giannattasio, P, DI IORIO, Br, Bellizzi, V, and Conte, Giuseppe

Published
2001

32. A New Lichen Depsidone from L Obaria Pulmonaria

Author

Pejin, B., Giuseppina Tommonaro, Iodice, C., Tesevic, V., Vajs, V., and Rosa, S.

Subjects
acetylcholinesterase inhibitory activity, Lobariaceae, aromatic natural product, Alzheimer's disease
Abstract

The continuation of our phytochemical survey of Lobaria pulmonaria (L.) Hoffm. (Lobariaceae), has led to the isolation and identification of a new lichen depsidone (1) characterised by the normal analytical and spectroscopic techniques. Unlike previously isolated depsidone (2) from the same species, the compound 1 has not showed activity in the acetylcholinesterase inhibition test on Thin-layer chromatography plate.

Published
2012

33. Prevenzione della nefrolitiasi calcica

Author

TUCCILLO S, GIANNATTASIO P, CIOFFI M, ESPOSITO L, BELLIZZI V, ANDREUCCI M, IODICE C, CONTE, Giuseppe, MINUTOLO, Roberto, Tuccillo, S, Giannattasio, P, Cioffi, M, Esposito, L, Bellizzi, V, Andreucci, M, Minutolo, Roberto, Iodice, C, and Conte, Giuseppe

Published
2000

35. Patogenesi del rebound post-dialitico del fosforo

Author

GIANNATTASIO P, BELLIZZI V, CATAPANO F, CIOFFI M, DI IORIO BR, ESPOSITO L, IODICE C, MAIONE E, TERRACCIANO V, TUCCILLO S, ZAMBOLI, Pasquale, MINUTOLO, Roberto, Giannattasio, P, Bellizzi, V, Catapano, F, Cioffi, M, DI IORIO, Br, Esposito, L, Iodice, C, Maione, E, Terracciano, V, Tuccillo, S, Zamboli, Pasquale, and Minutolo, Roberto

Published
2000

38. Sugar composition of the moss Rhodobryum ontariense (Kindb.) Kindb

Author

Pejin B., Iodice C., Tommonaro G., Sabovljevic M., Bianco A., Tesevic V., Vajs V., and De Rosa S.

Subjects
mosses, Rhodobryum ontariense, phytochemistry, fructooligosaccharides, 1-kestose
Abstract

Although the second biggest terrestrial group of plants, bryophytes remain poorly known chemically compared to the angiosperms. In this article, the sugars of the moss Rhodobryum ontariense, an unstudied representative of the medicinally known genus, are reported. The chemical analysis revealed the usual plant sugar sucrose, and a new sugar, fructooligosaccharide 1- kestose, which is reported first not only for the genus Rhodobryum, but also for mosses. The trisaccharides have been scantily reported in bryophytes hitherto. This gives more significance to this study for further investigation of its role in the moss species. The health-promoting effect of 1-kestose is also briefly discussed.

Published
2011

44. Role of acid-base balance and plasma sodium in post-dialytic potassium rebound

Author

Giannattasio P, Cioffi M, MINUTOLO, Roberto, Tuccillo S, Esposito L, Cappabianca F, Iodice C, Bellizzi V, DE NICOLA, Luca, CONTE, Giuseppe, De Santo NG, Giannattasio, P, Cioffi, M, Minutolo, Roberto, Tuccillo, S, Esposito, L, Cappabianca, F, Iodice, C, Bellizzi, V, DE NICOLA, Luca, and Conte, Giuseppe

Published
1999

45. How the ovarian follicle of Podarcis sicula recycles the DNA of its nurse, regressing follicle cells

Author

DE CARO M, INDOLFI P, IODICE C, SPAGNUOLO S, TAMMARO, STEFANIA, MOTTA, CHIARA MARIA, DE CARO, M, Indolfi, P, Iodice, C, Spagnuolo, S, Tammaro, Stefania, and Motta, CHIARA MARIA

Subjects
Electrophoresis, Agar Gel, Transglutaminases, oogenesis, Vitellogenesis, Lizards, DNA, apoptosi, Microscopy, Electron, follicular epithelium, Ovarian Follicle, Animals, remodelling, Electrophoresis, Polyacrylamide Gel, Female, DNA recycling, lacertid
Abstract

In Podarcis sicula specialized follicle cells send reserve materials to the previtellogenic oocyte via intercellular bridges. Immediately before the onset of vitellogenesis this transferring becomes particularly massive so that the cell volume significantly reduces, meanwhile in the nucleus the morphological alterations typical of apoptosis appear. To clarify why these follicle cells are not simply fully resorbed by the oocyte and to determine whether their DNA is discarded or recycled, we carried out a series of morphological and biochemical investigations. The finding that large macromolecular scaffolds are formed and that these are able to retain the DNA until it is extensively cut by two different endonucleases suggests that regression of the follicle cells is programmed and that the fate of their DNA is strictly controlled. Following its genetical neutralization via fragmentation, the DNA is apparently recycled by being transferred into the oocyte via the intercellular bridges, that, in fact, remain open until the very late stages of cell regression. The small DNA fragments reaching the oocyte cytoplasm would not interfere with meiosis completion but could significantly contribute to the stock of reserve materials to the advantage of the growing oocyte and/or developing embryo.

Published
1998

48. Global approach to cardiovascular risk in chronic kidney disease: reality and opportunities for intervention

Author

De Nicola, L, Minutolo, R, Chiodini, P, Zoccali, C, Castellino, P, Donadio, C, Strippoli, M, Casino, F, Giannattasio, M, Petrarulo, F, Virgilio, M, Laraia, E, Di Iorio, B, Savica, V, Conte, G, Zamboli, P, Catapano, F, Maione, E, Tirino, G, Venditti, G, Avino, D, Borrelli, S, Scigliano, R, Materiale, T, Signoriello, G, Gallo, C, Cianciaruso, B, Torraca, S, Pota, A, Andreucci, Ve, Nappi, F, Avella, F, Di Iorio BR, Bellizzi, V, D'Apice, L, Mangiacapra, S, Caserta, D, Cestaro, R, Marzano, L, Giannattasio, P, Martignetti, V, Morrone, L, Budetta, F, Gigliotti, G, Iodice, C, Rubino, R, Lupo, A, Conte, M, Panichi, V, Bonomini, M, Sirolli, V, Lopez, T, Detomaso, F, Elia, F, Tarantino, G, Cristofano, C, Chimienti, S, Montanaro, A, Giordano, R, Marangi, A, Giancaspro, V, Gallucci, M, Gigante, B, Lodeserto, C, Santese, D, Caglioti, A, Mancuso, D, Fuiano, G, Mallamaci, F, Postorino, M, Monardo, P, Bellinghieri, G, Mallamace, A, Rapisarda, F, Fatuzzo, P, Messina, A, DE NICOLA, Luca, Minutolo, Roberto, Chiodini, Paolo, Zamboni, P., Zoccali, C., Castellino, P., Donadio, C., Strippoli, M., Casino, F., Giannattasio, M., Petrarulo, F., Virgilio, M., Laraia, E., DI IORIO, B., Savica, V., and Conte, Giuseppe

Subjects
Nephrology, Male, epoietin, medicine.medical_specialty, Anemia, Cross-sectional study, diuretic, Hypercholesterolemia, Severity of Illness Index, Risk Factors, Internal medicine, Diabetes mellitus, medicine, CKD, Diabetes Mellitus, Odds Ratio, Prevalence, Humans, Antihypertensive Agents, Aged, Aged, 80 and over, business.industry, statin, Odds ratio, Middle Aged, medicine.disease, diuretics, Confidence interval, Surgery, Proteinuria, Cross-Sectional Studies, Italy, Cardiovascular Diseases, Chronic Disease, Hypertension, Practice Guidelines as Topic, Female, Hypertrophy, Left Ventricular, Kidney Diseases, sodium excretion, business, Dyslipidemia, Kidney disease
Abstract

The current implementation into nephrology clinical practice of guidelines on treatment of cardiovascular (CV) risk factors in chronic kidney disease (CKD) is unknown. We designed a cross-sectional analysis to evaluate the prevalence and treatment of eight modifiable CV risk factors in 1058 predialysis CKD patients (stage 3: n =486; stage 4: n =430, stage 5: n =142) followed for at least 1 year in 26 Italian renal clinics. The median nephrology follow-up was 37 months (range: 12–391 months). From stages 3 to 5, hypertension was the main complication (89, 87, and 87%), whereas smoking, high calcium-phosphate product and malnutrition were uncommon. The prevalence of proteinuria (25, 38, and 58%), anemia (16, 32, and 51%) and left ventricular hypertrophy (51, 55, and 64%) significantly increased, while hypercholesterolemia was less frequent in stage 5 (49%) than in stages 4 and 3 (59%). The vast majority of patients received multidrug antihypertensive therapy including inhibitors of renin–angiotensin system; conversely, diuretic treatment was consistently inadequate for both frequency and dose despite scarce implementation of low salt diet (19%). Statins were not prescribed in most hypercholesterolemics (78%), and epoietin treatment was largely overlooked in anemics (78%). The adjusted risk for having a higher number of uncontrolled risk factors rose in the presence of diabetes (odds ratio 1.29, 95% confidence interval 1.00–1.66), history of CV disease (odds ratio 1.48, 95% confidence interval 1.15–1.90) and CKD stages 4 and 5 (odds ratio 1.75, 95% confidence interval 1.37–2.22 and odds ratio 2.85, 95% confidence interval 2.01–4.04, respectively). In the tertiary care of CKD, treatment of hypertension is largely inadequate, whereas therapy of anemia and dyslipidemia is frequently omitted. The risk of not achieving therapeutic targets is higher in patients with diabetes, CV disease and more advanced CKD.

Published
2006

49. Estimation of seismic ground motion in Rome

Author

Fäh D., Iodice C., SUHADOLC, PETER, PANZA, GIULIANO, Guoyu D. and Zhangli C., Fäh, D., Iodice, C., Suhadolc, Peter, and Panza, Giuliano

Subjects
Seismology
Published
1993

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