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2. Global variation in the long-term outcomes of ypT0 rectal cancers

Author

Terrenato, Irene, Shinde, Rajesh S., Saklani, Avanish, Martins, Pedro, Videira, José Flávio, Bonci, Eduard-Alexandru, Achimas-Cadariu, Patriciu, Marinello, Franco, Espin, Eloy, Xenaki, Sofia, Lasithiotakis, Konstantinos, Rega, Daniela, Delrio, Paolo, Andrási, László, Lázár, György, Quattromani, Roberto, Elmore, Ugo, Branciforte, Martina Azzurra, Piazza, Diego, Sztipits, Tamás, Mersich, Tamás, Vigorita, Vincenzo, Ildefonso, Alberto San, Cianflocca, Desiree, Giuffrida, Maria Carmela, Biondi, Alberto, Persiani, Roberto, Košir, Jurij Aleš, Grosek, Jan, Rizzo, Gianluca, Coco, Claudio, Dieninyte-Misiune, Egle, Bausys, Rimantas, Bausys, Augustinas, Poskus, Tomas, Dupré, Aurélien, Muresan, Mihai-Stefan, Ionescu, Călin, Alyami, Mohammad, Cotte, Eddy, Candido, Francesca Di, Spinelli, Antonino, Lucarini, Alessio, Balducci, Genoveffa, Kisielewski, Michał, Pędziwiatr, Michał, Kroon, Hidde, Sammour, Tarik, Unger, Lukas, Stift, Anton, Marsanic, Patrizia, Muratore, Andrea, Uzunoglu, Mustafa Yener, Altintoprak, Fatih, Capponi, Michela Giulii, Poiasina, Elia, Brandl, Andreas, Aigner, Felix, Aparício, David, Leichsenring, Carlos, Corleone, Pio, Manzini, Nicolò de, Kabata, Paweł, Świerblewski, Maciej, Gallo, Gaetano, Trompetto, Mario, Negoi, Ionut, Beuran, Mircea, Souriti, Ahmad, Taylor, Gregory, De Luca, Raffaele, Simone, Michele, Bedford, Matthew, Charalampakis, Vasileios, Rajan, Shiv, Chaturvedi, Arun, Veltri, Marco, Parini, Dario, Turati, Luca, Sgroi, Giovanni, Bratu, Matei, Diaconescu, Bogdan, Slavchev, Mihail, Belev, Nikolay, Perfumo, Mariana Matzner, Rotholtz, Nicolas, Wajda, Justyna, Wysocki, Wojciech, Fernandez, Carmen Cagigas, Ruiz, Marcos Gomez, Marino, Serafino, Resta, Giuseppe, Ivanov, Tsvetomir, Dimitrov, Dobromir, Kaufmann, Claudia, Kafka-Ritsch, Reinhold, Yalkin, Omer, Ünal, Ali Ekrem, Loche, Giovanni Augusto, Cillara, Nicola, Colombo, Francesco, Foschi, Diego, Pollesel, Sara, Roviello, Franco, Lorenzon, Laura, Evrard, Serge, Beets, Geerard, Gonzalez-Moreno, Santiago, Kovacs, Tibor, D’Ugo, Domenico, and Polom, Karol

Published
2020
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4. The silent healer: miR-205-5p up-regulation inhibits epithelial to mesenchymal transition in colon cancer cells by indirectly up-regulating E-cadherin expression

Author

Gulei, Diana, Magdo, Lorand, Jurj, Ancuta, Raduly, Lajos, Cojocneanu-Petric, Roxana, Moldovan, Alin, Moldovan, Cristian, Florea, Adrian, Pasca, Sergiu, Pop, Laura-Ancuta, Moisoiu, Vlad, Budisan, Liviuta, Pop-Bica, Cecilia, Ciocan, Cristina, Buiga, Rares, Muresan, Mihai-Stefan, Stiufiuc, Rares, Ionescu, Calin, and Berindan-Neagoe, Ioana

Published
2018
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7. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

Author

Ling, Hui, Pickard, Karen, Ivan, Cristina, Isella, Claudio, Ikuo, Mariko, Mitter, Richard, Spizzo, Riccardo, Bullock, Marc D, Braicu, Cornelia, Pileczki, Valentina, Vincent, Kimberly, Pichler, Martin, Stiegelbauer, Verena, Hoefler, Gerald, Almeida, Maria I, Hsiao, Annie, Zhang, Xinna, Primrose, John N, Packham, Graham K, Liu, Kevin, Bojja, Krishna, Gafà, Roberta, Xiao, Lianchun, Rossi, Simona, Song, Jian H, Vannini, Ivan, Fanini, Francesca, Kopetz, Scott, Zweidler-McKay, Patrick, Wang, Xuemei, Ionescu, Calin, Irimie, Alexandru, Fabbri, Muller, Lanza, Giovanni, Hamilton, Stanley R, Berindan-Neagoe, Ioana, Medico, Enzo, Mirnezami, Alex H, Calin, George A, and Nicoloso, Milena S

Published
2016
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8. SERS-based differential diagnosis between multiple solid malignancies: breast, colorectal, lung, ovarian and oral cancer

Author

Moisoiu,Vlad, Stefancu,Andrei, Gulei,Diana, Boitor,Radu, Magdo,Lorand, Raduly,Lajos, Pasca,Sergiu, Kubelac,Paul, Mehterov,Nikolay, Chis,Vasile, Simon,Marioara, Muresan,Mihai, Irimie,Alexandra Iulia, Baciut,Mihaela, Stiufiuc,Rares, Pavel,Ioana E, Achimas-Cadariu,Patriciu, Ionescu,Calin, Lazar,Vladimir, Sarafian,Victoria, Notingher,Ioan, Leopold,Nicolae, and Berindan-Neagoe,Ioana

Subjects
Male, surface-enhanced Raman scattering, Medicine (General), Lung Neoplasms, Silver, Metal Nanoparticles, Breast Neoplasms, Spectrum Analysis, Raman, solid malignancies, Diagnosis, Differential, R5-920, International Journal of Nanomedicine, Neoplasms, Humans, Surface-enhanced Raman scattering (SERS), Original Research, Aged, Ovarian Neoplasms, Principal Component Analysis, SERS, Discriminant Analysis, Middle Aged, principal component analysis-linear discriminant analysis, Case-Control Studies, Female, Mouth Neoplasms, Colorectal Neoplasms, serum
Abstract

Vlad Moisoiu,1,2,* Andrei Stefancu,1,3,*Diana Gulei,3,* Radu Boitor,4 Lorand Magdo,2,5 Lajos Raduly,5,6 Sergiu Pasca,2 Paul Kubelac,2,7 Nikolay Mehterov,8,9 Vasile Chiș,1 Marioara Simon,10 Mihai Muresan,2,11–12 Alexandra Iulia Irimie,13 Mihaela Baciut,14 Rares Stiufiuc,3,15 Ioana E Pavel,3,16 Patriciu Achimas-Cadariu,17,18 Calin Ionescu,2,11 Vladimir Lazar,19 Victoria Sarafian,8,9 Ioan Notingher,4 Nicolae Leopold,1,3 Ioana Berindan-Neagoe3,5,201Faculty of Physics, Babeș-Bolyai University, Cluj-Napoca, Romania; 2Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 3MedFuture - Research Center for Advanced Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4School of Physics and Astronomy, University of Nottingham, Nottingham, UK; 5Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 6Department of Pathophysiology, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania; 7Department of Medical Oncology, Prof. Dr. Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania; 8Department of Medical Biology, Faculty of Medicine, Medical University-Plovdiv, Plovdiv, Bulgaria; 9Technological Center for Emergency Medicine, Plovdiv, Bulgaria; 10Department of Bronchology, Leon Daniello Pneumophysiology Clinical Hospital, Cluj-Napoca, Romania; 115th Surgical Department, Cluj-Napoca Municipal Hospital, Cluj-Napoca, Romania; 12Department of Surgical and Gynecological Oncology, Prof. Dr. Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania; 13Department of Prosthetic Dentistry and Dental Materials, Division Dental Propaedeutics, Aesthetics, Faculty of Dentistry, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 14Department of Cranio-Maxillofacial Surgery and Dental Emergencies, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 15Department of Pharmaceutical Physics-Biophysics, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 16Department of Chemistry, Wright State University, Dayton, OH, USA; 17Department of Surgery, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 18Department of Surgical Oncology, Prof. Dr. Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania; 19Worldwide Innovative Network for Personalized Cancer Therapy, Villejuif, France; 20Department of Functional Genomics and Experimental Pathology, Prof. Dr. Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania*These authors contributed equally to this workPurpose: Surface-enhanced Raman scattering (SERS) spectroscopy on serum and other biofluids for cancer diagnosis represents an emerging field, which has shown promising preliminary results in several types of malignancies. The purpose of this study was to demonstrate that SERS spectroscopy on serum can be employed for the differential diagnosis between five of the leading malignancies, ie, breast, colorectal, lung, ovarian and oral cancer.Patients and methods: Serum samples were acquired from healthy volunteers (n=39) and from patients diagnosed with breast (n=42), colorectal (n=109), lung (n=33), oral (n=17), and ovarian cancer (n=13), comprising n=253 samples in total. SERS spectra were acquired using a 532nm laser line as excitation source, while the SERS substrates were represented by Ag nanoparticles synthesized by reduction with hydroxylamine. The classification accuracy yielded by SERS was assessed by principal component analysis–linear discriminant analysis (PCA-LDA).Results: The sensitivity and specificity in discriminating between cancer patients and controls was 98% and 91%, respectively. Cancer samples were correctly assigned to their corresponding cancer types with an accuracy of 88% for oral cancer, 86% for colorectal cancer, 80% for ovarian cancer, 76% for breast cancer and 59% for lung cancer.Conclusion: SERS on serum represents a promising strategy of diagnosing cancer which can discriminate between cancer patients and controls, as well as between cancer types such as breast, colorectal, lung ovarian and oral cancer.Keywords: surface-enhanced Raman scattering, SERS, serum, principal component analysis-linear discriminant analysis, solid malignancies

Published
2019

9. Epithelial–Mesenchymal Transition Gene Signature Related to Prognostic in Colon Adenocarcinoma

Author

Busuioc, Constantin, primary, Ciocan-Cartita, Cristina Alexandra, additional, Braicu, Cornelia, additional, Zanoaga, Oana, additional, Raduly, Lajos, additional, Trif, Monica, additional, Muresan, Mihai-Stefan, additional, Ionescu, Calin, additional, Stefan, Cristina, additional, Crivii, Carmen, additional, Al Hajjar, Nadim, additional, Mǎrgǎrit, Simona, additional, and Berindan-Neagoe, Ioana, additional

Published
2021
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10. Hsa-miR-125b Therapeutic Role in Colon Cancer Is Dependent on the Mutation Status of the TP53 Gene

Author

Cenariu, Diana, primary, Zimta, Alina-Andreea, additional, Munteanu, Raluca, additional, Onaciu, Anca, additional, Moldovan, Cristian Silviu, additional, Jurj, Ancuta, additional, Raduly, Lajos, additional, Moldovan, Alin, additional, Florea, Adrian, additional, Budisan, Liviuta, additional, Pop, Laura Ancuta, additional, Magdo, Lorand, additional, Albu, Mihai Tudor, additional, Tonea, Rares Bogdan, additional, Muresan, Mihai-Stefan, additional, Ionescu, Calin, additional, Petrut, Bogdan, additional, Buiga, Rares, additional, Irimie, Alexandru, additional, Gulei, Diana, additional, and Berindan-Neagoe, Ioana, additional

Published
2021
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11. Circulating microRNA-194 and microRNA-1228 Could Predict Colon Cancer Proliferation via Phospho S6 Modulation

Author

Pasca, Sergiu, primary, Ionescu, Calin, primary, Andras, David, primary, Eniu, Dan, primary, Muresan, Mihai Andrei, primary, Magdo, Lorand, primary, Jurj, Ancuta, primary, Raduly, Lajos, primary, Cojocneanu, Roxana, primary, Petrushev, Bobe, primary, Zaharie, Florin, primary, Irimie, Alexandru, primary, Berindan-Neagoe, Ioana, primary, and Muresan, Mihai Stefan, primary

Published
2020
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13. Plasma and Tissue Specific miRNA Expression Pattern and Functional Analysis Associated to Colorectal Cancer Patients

Author

Cojocneanu, Roxana, primary, Braicu, Cornelia, additional, Raduly, Lajos, additional, Jurj, Ancuta, additional, Zanoaga, Oana, additional, Magdo, Lorand, additional, Irimie, Alexandru, additional, Muresan, Mihai-Stefan, additional, Ionescu, Calin, additional, Grigorescu, Mircea, additional, and Berindan-Neagoe, Ioana, additional

Published
2020
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14. Critical function of circular RNAs in lung cancer

Author

Drula, Rares, primary, Braicu, Cornelia, additional, Harangus, Antonia, additional, Nabavi, Seyed M., additional, Trif, Monica, additional, Slaby, Ondrej, additional, Ionescu, Calin, additional, Irimie, Alexandru, additional, and Berindan‐Neagoe, Ioana, additional

Published
2020
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15. Nanoscale delivery systems for microRNAs in cancer therapy

Author

Boca, Sanda, primary, Gulei, Diana, additional, Zimta, Alina-Andreea, additional, Onaciu, Anca, additional, Magdo, Lorand, additional, Tigu, Adrian Bogdan, additional, Ionescu, Calin, additional, Irimie, Alexandru, additional, Buiga, Rares, additional, and Berindan-Neagoe, Ioana, additional

Published
2019
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17. Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines—Possible Implications in New Therapeutic Strategies

Author

Budisan, Liviuta, primary, Gulei, Diana, additional, Jurj, Ancuta, additional, Braicu, Cornelia, additional, Zanoaga, Oana, additional, Cojocneanu, Roxana, additional, Pop, Laura, additional, Raduly, Lajos, additional, Barbat, Alexandru, additional, Moldovan, Alin, additional, Moldovan, Cristian, additional, Tigu, Adrian, additional, Ionescu, Calin, additional, Atanasov, Atanas, additional, Irimie, Alexandru, additional, and Berindan-Neagoe, Ioana, additional

Published
2019
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20. The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis

Author

Ling, Hui, primary, Pickard, Karen, additional, Ivan, Cristina, additional, Isella, Claudio, additional, Ikuo, Mariko, additional, Mitter, Richard, additional, Spizzo, Riccardo, additional, Bullock, Marc D, additional, Braicu, Cornelia, additional, Pileczki, Valentina, additional, Vincent, Kimberly, additional, Pichler, Martin, additional, Stiegelbauer, Verena, additional, Hoefler, Gerald, additional, Almeida, Maria I, additional, Hsiao, Annie, additional, Zhang, Xinna, additional, Primrose, John N, additional, Packham, Graham K, additional, Liu, Kevin, additional, Bojja, Krishna, additional, Gafà, Roberta, additional, Xiao, Lianchun, additional, Rossi, Simona, additional, Song, Jian H, additional, Vannini, Ivan, additional, Fanini, Francesca, additional, Kopetz, Scott, additional, Zweidler-McKay, Patrick, additional, Wang, Xuemei, additional, Ionescu, Calin, additional, Irimie, Alexandru, additional, Fabbri, Muller, additional, Lanza, Giovanni, additional, Hamilton, Stanley R, additional, Berindan-Neagoe, Ioana, additional, Medico, Enzo, additional, Mirnezami, Alex H, additional, Calin, George A, additional, and Nicoloso, Milena S, additional

Published
2015
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22. Critical function of circular RNAs in lung cancer.

Author

Drula R, Braicu C, Harangus A, Nabavi SM, Trif M, Slaby O, Ionescu C, Irimie A, and Berindan-Neagoe I

Subjects
Animals, Humans, Lung Neoplasms drug therapy, Lung Neoplasms metabolism, Lung Neoplasms pathology, Molecular Targeted Therapy, RNA Interference, RNA, Circular chemistry, Signal Transduction, Structure-Activity Relationship, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Lung Neoplasms genetics, RNA, Circular genetics
Abstract

Lung cancer is one of the main causes of cancer-related death in the world, especially due to its frequency and ineffective therapeutically approaches in the late stages of the disease. Despite the recent advent of promising new targeted therapies, lung cancer diagnostic strategies still have difficulty in identifying the disease at an early stage. Therefore, the characterizations of more sensible and specific cancer biomarkers have become an important goal for clinicians. Circular RNAs (circRNAs), a type of RNA with covalently closed continuous loop structures that display high structural resistance and tissue specificity pointed toward a potential biomarker role. Current investigations have identified that circRNAs have a prominent function in the regulation of oncogenic pathways, by regulating gene expression both at transcriptional and post-transcriptional level. The aim of this review is to provide novel information regarding the implications of circRNAs in lung cancer, with an emphasis on the role in disease development and progression. Initially, we explored the potential utility of circRNAs as biomarkers, focusing on function, mechanisms, and correlation with disease progression in lung cancer. Further, we will describe the interaction between circRNAs and other non-coding species of RNA (particularly microRNA) and their biological significance in lung cancer. Describing the nature of these interactions and their therapeutic potential will provide additional insight regarding the altered molecular landscape of lung cancer and consolidate the potential clinical value of these circular transcripts. This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development., (© 2020 Wiley Periodicals, Inc.)

Published
2020
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23. A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer.

Author

Braicu C, Buse M, Busuioc C, Drula R, Gulei D, Raduly L, Rusu A, Irimie A, Atanasov AG, Slaby O, Ionescu C, and Berindan-Neagoe I

Abstract

The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and epigenetic changes. Numerous studies focused on both the homeostatic and the pathologic conduct of MAPK signaling; however, there is still much to be deciphered in terms of regulation and action models in both preclinical and clinical research. MAPK has implications in the response to cancer therapy, particularly the activation of the compensatory pathways in response to experimental MAPK inhibition. The present paper discusses new insights into MAPK as a complex cell signaling pathway with roles in the sustenance of cellular normal conduit, response to cancer therapy, and activation of compensatory pathways. Unfortunately, most MAPK inhibitors trigger resistance due to the activation of compensatory feed-back loops in tumor cells and tumor microenvironment components. Therefore, novel combinatorial therapies have to be implemented for cancer management in order to restrict the possibility of alternative pathway activation, as a perspective for developing novel therapies based on integration in translational studies., Competing Interests: The authors have no conflicts of interest to declare.

Published
2019
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24. The venous thrombosis of the pancreatic graft.

Author

Ionescu C, Wolf P, Ellero B, and Mihaescu G

Subjects
Adolescent, Adult, Diabetes Mellitus, Type 1 surgery, Female, Follow-Up Studies, Humans, Immunosuppression Therapy, Kidney Transplantation, Male, Middle Aged, Monitoring, Physiologic, Postoperative Care, Recurrence, Replantation, Risk Factors, Time Factors, Tissue Donors, Ultrasonography, Doppler, Pulsed, Graft Occlusion, Vascular, Iliac Vein, Pancreas Transplantation adverse effects, Portal Vein, Venous Thrombosis diagnostic imaging, Venous Thrombosis prevention & control
Abstract

Background and Aims: Venous thrombosis of the pancreatic graft is the main nonimmunological cause of the loss of transplants. It has a frequency between 0.8 to 20% according to literature. In this study our team tried to identify the risk factors related to the donor, the recipient including the surgical techniques involved., Methods: The study was conducted in the Department of Transplant Surgery, University Hospital Strasbourg-Hautepierre. 37 patients, with type I diabetes who had been submitted to 7 transplantations of segmentary pancreas and 30 of total pancreas and kidney during 09.07.1992 and 14.08.2006 were included in the study. The surgery comprised the retroperitoneal placement of the pancreas and kidney and the anastomosis with the urinary bladder., Results: In the immediate evolution we observed 4 thromboses (10.5%). All 4 thromboses were in the group of kidney and total pancreas transplantations. Two of these 4 patients were retransplanted and presented recurrence of thrombosis at 17 days and 1 year., Conclusions: To prevent thrombosis, it is necessary to perform surgery which avoids unnecessary handling and which ensures broad, tension free vascular anastomoses. The method of early monitoring by pulsed Doppler related to the biological data and the clinical state are suggestive to diagnose thrombosis. The venous thrombosis of the graft implies pancreatic explantation. Retransplantation in patients who have undergone thrombosis of the graft is possible only in well selected patients.

Published
2007

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