1. Determinants of anti-S immune response at 6 months after COVID-19 vaccination in a multicentric European cohort of healthcare workers - ORCHESTRA project
- Author
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Collatuzzo, Giulia, Visci, Giovanni, Violante, Francesco S, Porru, Stefano, Spiteri, Gianluca, Monaco, Maria Grazia Lourdes, Larese Fillon, Francesca, Negro, Corrado, Janke, Christian, Castelletti, Noemi, De Palma, Giuseppe, Sansone, Emanuele, Mates, Dana, Teodorescu, Silvia, Fabiánová, Eleonóra, Bérešová, Jana, Vimercati, Luigi, Tafuri, Silvio, Abedini, Mahsa, Ditano, Giorgia, Asafo, Shuffield S, Boffetta, Paolo, Zunarelli, Carlotta, Bonfiglioli, Roberta, Carta, Angela, Verlato, Giuseppe, Lippi, Giuseppe, Gibellini, Davide, Pezzani, Maria Diletta, Torroni, Lorena, Hoelscher, Michael, Wieser, Andreas, Reinkemeyer, Christina, Plank, Michael, Noreña, Ivan, Rubio-Acero, Raquel, Winter, Simon, Leustean, Mihaela, Perseca, Ovidiu, Ipate, Madalina, Agripina, Rascu, Strhársky, Jozef, Hellebrandt, Petra, Križanová, Daniela, Mrázová, Marianna, De Maria, Luigi, Sponselli, Stefania, Stefanizzi, Pasquale, Caputi, Antonio, Collatuzzo G., Visci G., Violante F.S., Porru S., Spiteri G., Monaco M.G.L., Larese Fillon F., Negro C., Janke C., Castelletti N., De Palma G., Sansone E., Mates D., Teodorescu S., Fabianova E., Beresova J., Vimercati L., Tafuri S., Abedini M., Ditano G., Asafo S.S., and Boffetta P.
- Subjects
COVID-19 Vaccines ,vaccine, COVID – 19, serology, health care workers (HCW), immune response ,Health Personnel ,Immunology ,COVID – 19 ,Vaccination ,health care workers (HCW) ,Immunity ,immune response ,serology ,vaccine ,Infant ,COVID-19 ,Antibodies, Viral ,Antibodies ,Immunoglobulin G ,Immunology and Allergy ,Humans ,Female ,Viral ,Human - Abstract
BackgroundThe duration of immune response to COVID-19 vaccination is of major interest. Our aim was to analyze the determinants of anti-SARS-CoV-2 IgG titer at 6 months after 2-dose vaccination in an international cohort of vaccinated healthcare workers (HCWs).MethodsWe analyzed data on levels of anti-SARS-CoV-2 Spike antibodies and sociodemographic and clinical characteristics of 6,327 vaccinated HCWs from 8 centers from Germany, Italy, Romania and Slovakia. Time between 1st dose and serology ranged 150-210 days. Serological levels were log-transformed to account for the skewness of the distribution and normalized by dividing them by center-specific standard errors, obtaining standardized values. We fitted center-specific multivariate regression models to estimate the cohort-specific relative risks (RR) of an increase of 1 standard deviation of log antibody level and corresponding 95% confidence interval (CI), and finally combined them in random-effects meta-analyses.ResultsA 6-month serological response was detected in 99.6% of HCWs. Female sex (RR 1.10, 95%CI 1.00-1.21), past infection (RR 2.26, 95%CI 1.73-2.95) and two vaccine doses (RR 1.50, 95%CI 1.22-1.84) predicted higher IgG titer, contrary to interval since last dose (RR for 10-day increase 0.94, 95%CI 0.91-0.97) and age (RR for 10-year increase 0.87, 95%CI 0.83-0.92). M-RNA-based vaccines (pConclusionsFemale gender, young age, past infection, two vaccine doses, and m-RNA and heterologous vaccination predicted higher antibody level at 6 months. These results corroborate previous findings and offer valuable data for comparison with trends observed with longer follow-ups.
- Published
- 2022