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1,084 results on '"Irahara, Minoru"'

11. Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan

Author

Ueno, Keiko, primary, Kojima, Junya, additional, Suzuki, Kohta, additional, Kuwahara, Akira, additional, Higuchi, Yasuhiko, additional, Tanaka, Atsushi, additional, Utsunomiya, Takafumi, additional, Mio, Yasuyuki, additional, Nishi, Hirotaka, additional, Yoshimura, Yasunori, additional, Irahara, Minoru, additional, and Kuji, Naoaki, additional

Published
2023
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12. Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

Author

Yanagihara, Rie, Yamamoto, Yuri, Kawakita, Takako, Noguchi, Hiroki, Yano, Yuya, Hayashi, Noriko, Ohta, Chiaki, Minato, Saki, Kamada, Shuhei, Aoki, Hidenori, Tamura, Kou, Masaki, Rie, Tachibana, Ayaka, Arakaki, Ryosuke, Yoshida, Kanako, Kato, Takeshi, Irahara, Minoru, and Iwasa, Takeshi

Subjects
endocrine system, biotin, IVF/ICSI, pregnancy, follicular fluid
Abstract

It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.

Published
2022

13. Effect of intraperitoneal docetaxel on ovarian function in mice

Author

Yoshida, Kanako, primary, Erdenebayar, Otgontsetseg, additional, Kadota, Yuri, additional, Kasai, Kana, additional, Kawakita, Takako, additional, Shinya, Akari, additional, Sasasda, Hikari, additional, Katayama, Sachiko, additional, Nii, Mari, additional, Imaizumi, Junki, additional, Kamada, Shuuhei, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Yamamoto, Yuri, additional, Kato, Takeshi, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2022
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16. Compatible cut‐off values for luteinizing hormone and the luteinizing hormone/follicle‐stimulating hormone ratio in diagnostic criteria of the Japan Society of Obstetrics and Gynecology for polycystic ovary syndrome

Author

Yanagihara, Rie, primary, Matsuzaki, Toshiya, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Nagashima, Mao, additional, Minato, Saki, additional, Kamada, Shuhei, additional, Yamamoto, Yuri, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2022
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23. Effects of oxytocin in postmenopausal rats

Author

Erdenebayar, Otgontsetseg, Kato, Takeshi, Kawakita, Takako, Kasai, Kana, Kadota, Yuri, Yoshida, Kanako, Iwasa, Takeshi, and Irahara, Minoru

Subjects
Adipocyte, peri- and postmenopause, Food intake, Menopause, Body weight, Oxytocin, feeding function, hormones, hormone substitutes, and hormone antagonists, metabolic function
Abstract

Recent studies have revealed that the administration of oxytocin has beneficial effects on the regulation of body weight, food intake, and metabolic functions, especially in obese individuals. Obesity is common in women after the menopause and drives many components of metabolic syndrome. Weight gain in menopausal women has been frequently reported. Although obesity and associated metabolic disorders are frequently observed in peri- and postmenopausal women, there are few medical interventions for these conditions. In this study, we evaluated the effects of chronic oxytocin administration on appetite, body weight, and fat mass in peri- and postmenopausal female rats. Sixteen naturally premenopausal or menopausal rats were intraperitoneally injected with oxytocin (1,000 μg/day) for 12 days. The daily changes in their body weight and food intake were measured at the same time as the oxytocin and vehicle injections. Intraperitoneally administering oxytocin for 12 days significantly reduced food intake, body weight, and visceral adipocyte size. In addition, oxytocin administration caused reductions in serum triglyceride and low-density lipoprotein-cholesterol levels, while it did not disturb hepatic or renal functions or locomotor activity. This is the first study to show the effects of oxytocin on the metabolic and feeding functions of peri- and postmenopausal female rats. Oxytocin might be a useful treatment for metabolic disorders caused by the menopause or aging.

Published
2021

24. Prospects for maternal and child health in Japan

Author

Morioka, Hisayoshi, Watanabe, Hiroyoshi, Iwasa, Hajime, Kagami, Shoji, Irahara, Minoru, Morioka, Hisayoshi, Watanabe, Hiroyoshi, Iwasa, Hajime, Kagami, Shoji, and Irahara, Minoru

Abstract

In Japan, outcome measures for maternal and child health measures such as maternal, perinatal, and infant mortality have consistently shown a trend toward improvement. On the other hand, the problems of the declining birth rate, child abuse, and domestic violence have become evident since the 1990s. In terms of Japan’s maternal and child health, it is necessary to take measures to preserve mental health of mothers and children, and also to respond to family issues such as abuse and violence. The services needed such as comprehensive support centers for families with children and new postpartum care programs have been established. It is necessary to further improve the competence of doctors, public health nurses, and midwives working in the maternal and child health field and to promptly construct a cooperation system in the community.

Published
2022

25. Transgender man receiving testosterone treatment became pregnant and delivered a girl : A case report

Author

Yoshida, Atsuko, Kaji, Takashi, Imaizumi, Junki, Shirakawa, Aya, Suga, Kenichi, Nakagawa, Ryuji, Maeda, Kazuhisa, Irahara, Minoru, Iwasa, Takeshi, Yoshida, Atsuko, Kaji, Takashi, Imaizumi, Junki, Shirakawa, Aya, Suga, Kenichi, Nakagawa, Ryuji, Maeda, Kazuhisa, Irahara, Minoru, and Iwasa, Takeshi

Abstract

Many transgender men receive testosterone therapy to achieve virilization. The therapy is often mistaken for having a contraceptive effect because it causes amenorrhea. However, some treated patients become pregnant, which is not well known. A 25-year-old transgender man who had received testosterone for 3 years had an unplanned pregnancy during discontinuation of treatment. He was unaware of his pregnancy, resumed testosterone, and continued treatment until pregnancy was confirmed. His female child was exposed to androgens during the fetal period; thus, careful, long-term observation was required. He developed insomnia and depression during the postpartum, and giving birth made it difficult for him to change his family register to male. Transgender men can become pregnant through sexual intercourse with biological men, even during hormone replacement therapy, so correct contraception is necessary to avoid unwanted pregnancies. Transgender sex education is important to increase awareness of this issue among individuals and medical professionals.

Published
2022

35. A practical survey of fertility‐preservation treatments in the startup phase in Japan

Author

Takae, Seido, primary, Kato, Keiichi, additional, Watanabe, Chie, additional, Nara, Kazuko, additional, Koizumi, Tomoe, additional, Kawai, Kiyotaka, additional, Ota, Kuniaki, additional, Yumura, Yasushi, additional, Yabuuchi, Akiko, additional, Kuwahara, Akira, additional, Furui, Tatsuro, additional, Takai, Yasushi, additional, Irahara, Minoru, additional, and Suzuki, Nao, additional

Published
2022
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36. 生後早期の心理的ストレスが雌雄ラットの性成熟、性行動に与える影響

Author

Yano, Kiyohito, Matsuzaki, Toshiya, Iwasa, Takeshi, Mayila, Yiliyasi, Yanagihara, Rie, Tungalagsuvd, Altankhuu, Munkhzaya, Munkhsaihan, Tokui, Takako, Kamada, Shuhei, Hayashi, Aki, Masaki, Rie, Aoki, Hidenori, Tamura, Kou, and Irahara, Minoru

Subjects
neonatal period, sexual behavior, early life stress, maternal separation, sexual maturation, psychological stress
Abstract

Purpose: We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats. Methods: Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age. Results: As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex. Conclusions: In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.

Published
2019

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