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1,043 results on '"Irahara, Minoru"'

9. Anthropometric measurements of term singletons at 6 years of age born from fresh and frozen embryo transfer: A multicenter prospective study in Japan

Author

Ueno, Keiko, primary, Kojima, Junya, additional, Suzuki, Kohta, additional, Kuwahara, Akira, additional, Higuchi, Yasuhiko, additional, Tanaka, Atsushi, additional, Utsunomiya, Takafumi, additional, Mio, Yasuyuki, additional, Nishi, Hirotaka, additional, Yoshimura, Yasunori, additional, Irahara, Minoru, additional, and Kuji, Naoaki, additional

Published
2023
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10. Biotin levels in blood and follicular fluid and their associations with pregnancy outcomes in IVF/ICSI patients

Author

Yanagihara, Rie, Yamamoto, Yuri, Kawakita, Takako, Noguchi, Hiroki, Yano, Yuya, Hayashi, Noriko, Ohta, Chiaki, Minato, Saki, Kamada, Shuhei, Aoki, Hidenori, Tamura, Kou, Masaki, Rie, Tachibana, Ayaka, Arakaki, Ryosuke, Yoshida, Kanako, Kato, Takeshi, Irahara, Minoru, and Iwasa, Takeshi

Subjects
endocrine system, biotin, IVF/ICSI, pregnancy, follicular fluid
Abstract

It has been shown that biotin, a water-soluble vitamin (B7), plays roles in reproductive functions, such as oocyte maturation and embryo development, in experimental animals. On the other hand, little is known about the clinical effects of biotin on human reproduction. In this study, serum and follicular fluid biotin levels were measured in patients who underwent in vitro fertilization / intracytoplasmic sperm injection (IVF / ICSI), and their associations with reproductive outcomes were evaluated. As a result, biotin was detected in follicular fluid, as well as serum, and the biotin levels of follicular fluid were found to be positively correlated with those of serum. The biotin levels of serum were higher than those of follicular fluid, suggesting that biotin may be taken up into the follicular fluid from the blood. Although serum and follicular fluid biotin levels tended to be higher in pregnant patients than in non-pregnant patients, these data did not show the significant statistical difference. These findings indicate that biotin does not contribute to the maintenance of oocyte quality, and hence, it does not increase fertilization and pregnancy rates.

Published
2022

13. Effect of intraperitoneal docetaxel on ovarian function in mice

Author

Yoshida, Kanako, primary, Erdenebayar, Otgontsetseg, additional, Kadota, Yuri, additional, Kasai, Kana, additional, Kawakita, Takako, additional, Shinya, Akari, additional, Sasasda, Hikari, additional, Katayama, Sachiko, additional, Nii, Mari, additional, Imaizumi, Junki, additional, Kamada, Shuuhei, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Yamamoto, Yuri, additional, Kato, Takeshi, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2022
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14. Compatible cut‐off values for luteinizing hormone and the luteinizing hormone/follicle‐stimulating hormone ratio in diagnostic criteria of the Japan Society of Obstetrics and Gynecology for polycystic ovary syndrome

Author

Yanagihara, Rie, primary, Matsuzaki, Toshiya, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Nagashima, Mao, additional, Minato, Saki, additional, Kamada, Shuhei, additional, Yamamoto, Yuri, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2022
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25. Effects of oxytocin in postmenopausal rats

Author

Erdenebayar, Otgontsetseg, Kato, Takeshi, Kawakita, Takako, Kasai, Kana, Kadota, Yuri, Yoshida, Kanako, Iwasa, Takeshi, and Irahara, Minoru

Subjects
Adipocyte, peri- and postmenopause, Food intake, Menopause, Body weight, Oxytocin, feeding function, hormones, hormone substitutes, and hormone antagonists, metabolic function
Abstract

Recent studies have revealed that the administration of oxytocin has beneficial effects on the regulation of body weight, food intake, and metabolic functions, especially in obese individuals. Obesity is common in women after the menopause and drives many components of metabolic syndrome. Weight gain in menopausal women has been frequently reported. Although obesity and associated metabolic disorders are frequently observed in peri- and postmenopausal women, there are few medical interventions for these conditions. In this study, we evaluated the effects of chronic oxytocin administration on appetite, body weight, and fat mass in peri- and postmenopausal female rats. Sixteen naturally premenopausal or menopausal rats were intraperitoneally injected with oxytocin (1,000 μg/day) for 12 days. The daily changes in their body weight and food intake were measured at the same time as the oxytocin and vehicle injections. Intraperitoneally administering oxytocin for 12 days significantly reduced food intake, body weight, and visceral adipocyte size. In addition, oxytocin administration caused reductions in serum triglyceride and low-density lipoprotein-cholesterol levels, while it did not disturb hepatic or renal functions or locomotor activity. This is the first study to show the effects of oxytocin on the metabolic and feeding functions of peri- and postmenopausal female rats. Oxytocin might be a useful treatment for metabolic disorders caused by the menopause or aging.

Published
2021

30. Preimplantation genetic testing for aneuploidy and chromosomal structural rearrangement: A summary of a nationwide study by the Japan Society of Obstetrics and Gynecology.

Author

Iwasa, Takeshi, Kuwahara, Akira, Takeshita, Toshiyuki, Taniguchi, Yuka, Mikami, Mikio, and Irahara, Minoru

Subjects
MATERNAL age, CHROMOSOMAL rearrangement, GENETIC testing, RECURRENT miscarriage, ANEUPLOIDY, EMBRYO implantation, BLASTOCYST, FROZEN human embryos
Abstract

Purpose: The Japan Society of Obstetrics and Gynecology conducted a nationwide clinical study to evaluate the pregnancy outcomes of preimplantation genetic testing for aneuploidy or chromosomal structural rearrangement (PGT‐A/SR). Methods: Patients that had experienced recurrent implantation failure, recurrent pregnancy loss, or chromosomal structural rearrangement were recruited from 200 fertility centers in Japan. For patients in whom one or more blastocysts were classified as euploid or euploid with suspected mosaicism, a frozen–thawed single embryo transfer (ET) was performed. Results: A total of 10 602 cycles, maternal age 28–50 years, were enrolled in this study. 42 529 blastocysts were biopsied, and 25.5%, 11.7%, and 61.7% of embryos exhibited euploidy, mosaicism, and aneuploidy, respectively. At least one euploid blastocyst was obtained in 38.3% of egg retrieval cycles with embryo biopsy. A total of 6080 ETs were carried out, and the clinical pregnancy rate per ET, ongoing pregnancy rate per ET, and miscarriage rate per pregnancy were 68.8%, 56.3%, and 10.4%, respectively. The rates of clinical pregnancy and miscarriage remained relatively constant across all maternal ages. Conclusions: Preimplantation genetic testing for aneuploidy or chromosomal structural rearrangement may improve the pregnancy rate per ET and reduce the miscarriage rate per pregnancy, especially in patients of advanced maternal age. [ABSTRACT FROM AUTHOR]

Published
2023
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31. Compatible cut‐off values for luteinizing hormone and the luteinizing hormone/follicle‐stimulating hormone ratio in diagnostic criteria of the Japan Society of Obstetrics and Gynecology for polycystic ovary syndrome.

Author

Yanagihara, Rie, Matsuzaki, Toshiya, Aoki, Hidenori, Tamura, Kou, Nagashima, Mao, Minato, Saki, Kamada, Shuhei, Yamamoto, Yuri, Irahara, Minoru, and Iwasa, Takeshi

Subjects
OBESITY, STATISTICS, FOLLICLE-stimulating hormone, POLYCYSTIC ovary syndrome, GYNECOLOGY, OBSTETRICS, IMMUNOASSAY, LUTEINIZING hormone, RESEARCH funding, DESCRIPTIVE statistics, LUMINESCENCE spectroscopy
Abstract

Aim: The abnormal secretion of luteinizing hormone (LH) is one of the typical features of polycystic ovary syndrome (PCOS) and adopted in the diagnostic criteria of the Japan Society of Obstetrics and Gynecology (JSOG). We investigated cut‐off values for LH and the LH/follicle‐stimulating hormone (FSH) ratio in resent two measurement systems for the diagnosis of PCOS. Methods: Ninety‐nine controls and 106 patients with PCOS were enrolled. Serum LH and FSH levels were measured using an electrochemiluminescence immunoassay (ARCHITECT) and chemiluminescence immunoassay (ECLusys). We examined the distribution of the measured levels, selected the conversion closest to the standard normal distribution in the control group, and calculated mean + 1 SD values for LH and the LH/FSH ratio as candidates. Cut‐off values coincided with the medians of the candidates in the two assay systems using a regression equation. We calculated the endocrinological abnormality rate in PCOS according to the JSOG criteria by abnormal LH secretion and elevated T. Results: Cut‐off values for LH (mIU/mL) and the LH/FSH ratio were 7.1 and 1.21, respectively, in ARCHITECT, and 9.9 and 1.51, respectively, in ECLusys. The detection rates of endocrinological abnormalities in PCOS were 72.2% and 70.6% in the nonoverweight/obese PCOS group and overweight/obese PCOS group, respectively, in ARCHITECT, and 69.4% and 73.5%, respectively, in ECLusys. Conclusion: We obtained cut‐off values of LH and the LH/FSH ratio for diagnostic criteria of JSOG criteria for PCOS, that were highly compatible between two major assay systems. These cut‐off values will contribute to the diagnosis of PCOS in Japan and presumably in women of Asian ethnicities. [ABSTRACT FROM AUTHOR]

Published
2023
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35. A practical survey of fertility‐preservation treatments in the startup phase in Japan

Author

Takae, Seido, primary, Kato, Keiichi, additional, Watanabe, Chie, additional, Nara, Kazuko, additional, Koizumi, Tomoe, additional, Kawai, Kiyotaka, additional, Ota, Kuniaki, additional, Yumura, Yasushi, additional, Yabuuchi, Akiko, additional, Kuwahara, Akira, additional, Furui, Tatsuro, additional, Takai, Yasushi, additional, Irahara, Minoru, additional, and Suzuki, Nao, additional

Published
2022
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38. 生後早期の心理的ストレスが雌雄ラットの性成熟、性行動に与える影響

Author

Yano, Kiyohito, Matsuzaki, Toshiya, Iwasa, Takeshi, Mayila, Yiliyasi, Yanagihara, Rie, Tungalagsuvd, Altankhuu, Munkhzaya, Munkhsaihan, Tokui, Takako, Kamada, Shuhei, Hayashi, Aki, Masaki, Rie, Aoki, Hidenori, Tamura, Kou, and Irahara, Minoru

Subjects
neonatal period, sexual behavior, early life stress, maternal separation, sexual maturation, psychological stress
Abstract

Purpose: We studied the influence of psychological stress during the early neonatal period on sexual maturation and sexual behavior in rats. Methods: Neonatal male and female rats were divided into control (C) and maternal separation (MS) groups (n = 20‐24 per group). The pups in the MS groups were placed in isolation cages for 240 minutes/d from postnatal days 2‐11. Vaginal opening (VO) in females and preputial separation (PS) in males (indicators of sexual maturation) were monitored, as was the estrous cycle in females. Thereafter, sexual behavior was monitored twice at 13 and 15 weeks of age. Results: As for sexual maturation, the onset of PS occurred significantly earlier in the MS group than in the C group, whereas the onset of VO did not differ between the groups. The length of the estrous cycle did not differ between the groups. The frequencies of sexual behaviors did not differ between the groups in either sex. Conclusions: In conclusion, early‐life psychological stress induced by MS advanced sexual maturation in male rats, whereas it did not affect sexual maturation in female rats. On the other hand, early‐life psychological stress might not affect sexual behavior in adulthood in either sex.

Published
2019

39. 正常妊婦および安静臥床を行った切迫早産妊婦における、超音波計測による大腿四頭筋の筋厚の変化について

Author

Takahashi, Yohei, Kaji, Takashi, Yasui, Toshiyuki, Yoshida, Atsuko, Yonetani, Naoto, Suzue, Naoto, Katoh, Shinsuke, Maeda, Kazuhisa, Sairyo, Koichi, Irahara, Minoru, and Iwasa, Takeshi

Subjects
threatened preterm labor, pregnancy, bed rest, muscle thickness, quadriceps femoris, Ultrasonography
Abstract

This study aimed to evaluate the changes in quadriceps femoris muscle thickness during the pregnancy and postpartum periods and to elucidate the effect of bed rest for threatened preterm labor on muscle thickness. In 26 women with normal pregnancy, quadriceps femoris thickness was measured at 11–13, 26, 30, and 35 weeks’ gestation, and at 3–5 days and 1 month postpartum using ultrasonography. In 15 pregnant women treated with bed rest for threatened premature labor, quadriceps femoris thickness was measured at 30 and 35 weeks’ gestation and postpartum. In women with normal pregnancy, quadriceps femoris thickness increased, peaking at 35 weeks’ gestation, followed by a postpartum decrease. In women on bed rest, quadriceps femoris thickness showed no significant change during the pregnancy and postpartum periods, and the muscle was significantly thinner at 35 weeks’ gestation than that in women with normal pregnancy. In conclusion, a significant increase in quadriceps femoris muscle thickness during normal pregnancy was found using ultrasonography. Meanwhile, in pregnant women on bed rest treatment, the quadriceps femoris was significantly thinner in the late third trimester than that in normal pregnant women. Prolonged bed rest can affect normal changes in the quadriceps femoris muscle thickness during the pregnancy and postpartum periods.

Published
2022

46. A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes

Author

Kamada, Shuhei, primary, Yamamoto, Yuri, additional, Aoki, Hidenori, additional, Tamura, Kou, additional, Takeda, Asuka, additional, Minato, Saki, additional, Masaki, Rie, additional, Yanagihara, Rie, additional, Hayashi, Noriko, additional, Yano, Yuya, additional, Imaizumi, Junki, additional, Kagawa, Tomohiro, additional, Yoshida, Atsuko, additional, Kawakita, Takako, additional, Irahara, Minoru, additional, and Iwasa, Takeshi, additional

Published
2021
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