8 results on '"Iraqi, N."'
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2. HYPOGONADISME HYPOGONADOTROPE
- Author
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IRAQI, N., BOUFARES, F., and BELMEJDOUB, G.
- Subjects
Hypogonadisme hypogonadotrope - Abstract
Il est défini par une synthèse insuffisante des gonadotrophines (LH et FSH) retentissant sur la fonction gonadique. Il peut être congénital ou acquis. Les déficits gonadotropes congénitaux peuvent être isolés avec anosmie définissant le syndrome de Kallmann, ou sans anosmie et sont classés alors parmi les hypogonadismes hypogonadotrophiques dits idiopathiques par anomalie de régulation de l’axe gonadotrope. Le déficit gonadotrope peut être aussi combiné à d’autres insuffisances antéhypophysaires ou à des associations endocriniennes ou syndromiques. Les hypogonadismes hypogonadotropes acquis sont le plus souvent dus aux adénomes hypophysaires, en particulier les prolactinomes, sans oublier les autres étiologies telles les processus infiltratifs ou les maladies de surcharge. Enfin, les hypogonadismes hypogonadotropes acquis fonctionnels sont le plus souvent la conséquence d’un déficit nutritionnel. L’Imagerie par résonnance magnétique (IRM) hypothalamo-hypophysaire est l’examen clé de l’exploration étiologique des déficits gonadotropes. Le traitement est substitutif dans le but, selon l’âge de diagnostic, de permettre le développement pubertaire normal, d’empêcher la régression des caractères sexuels secondaires et de promouvoir une vie sexuelle normale tout en assurant l’anabolisme osseux. Quant à l’infertilité, elle est corrigée, dans les deux sexes, selon l’origine et l’importance du déficit, par l’administration pulsatile de GnRH ou par les gonadotrophines. En considérant les hypogonadismes hypogonadotropes aussi bien chez l’homme que chez la femme, les auteurs soulignent l’intérêt d’une démarche diagnostique précise et d’une prise en charge thérapeutique adéquate de ces hypogonadismes tout en exposant leurs étiologies et les avancées récentes en biologie moléculaire., Maroc Médical, Vol. 32, No 3 (2010)
- Published
- 2013
- Full Text
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3. Déficit isolé en glucocorticoïde, quelle surveillance ? À propos d’un cas
- Author
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Iraqi, N., primary and Gaouzi, A., additional
- Published
- 2013
- Full Text
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4. 45,X/46,XY mosaicisme: Report of five cases and clinical review
- Author
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El Moussaif, N., primary, Haddad, N. El, additional, Iraqi, N., additional, and Gaouzi, A., additional
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- 2011
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5. Choix de sexe dans les dysgénésies gonadiques partielles XY (cas clinique)
- Author
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Iraqi, N., primary, Gaouzi, A., additional, and Bouhafs, M.A., additional
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- 2010
- Full Text
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6. Completeness of revascularization by FFR CT in stable angina: Association to adverse cardiovascular outcomes.
- Author
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Madsen KT, Nørgaard BL, Øvrehus KA, Jensen JM, Parner E, Grove EL, Mortensen MB, Iraqi N, Fairbairn TA, Nieman K, Patel MR, Rogers C, Mullen S, Mickley H, Thomsen KK, Bøtker HE, Leipsic J, and Rønnow Sand NP
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Treatment Outcome, Risk Factors, Time Factors, Risk Assessment, Severity of Illness Index, Coronary Vessels diagnostic imaging, Coronary Vessels physiopathology, Myocardial Revascularization, Myocardial Infarction mortality, Myocardial Infarction physiopathology, Myocardial Infarction diagnostic imaging, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease physiopathology, Coronary Artery Disease mortality, Multidetector Computed Tomography, Fractional Flow Reserve, Myocardial, Angina, Stable physiopathology, Angina, Stable mortality, Angina, Stable diagnostic imaging, Angina, Stable surgery, Angina, Stable therapy, Coronary Angiography, Predictive Value of Tests, Coronary Stenosis diagnostic imaging, Coronary Stenosis physiopathology, Coronary Stenosis mortality, Coronary Stenosis surgery, Computed Tomography Angiography
- Abstract
Background: The prognostic impact of complete coronary revascularization relative to non-invasive testing methods is unknown., Objectives: To assess the association between completeness of revascularization defined by CTA-derived fractional flow reserve (FFR
CT ) and cardiovascular outcomes in patients with stable angina., Methods: Multicenter 3-year follow-up study of patients with new onset stable angina and ≥ 30% stenosis by CTA. The lesion-specific FFRCT value (two cm-distal-to-stenosis) was registered in all vessels with stenosis and considered abnormal when ≤ 0.80. Patients with FFRCT ≤ 0.80 were categorized as: Completely revascularized (CR-FFRCT ), all vessels with FFRCT ≤ 0.80 revascularized; incompletely revascularized (IR-FFRCT ), ≥ 1 vessels with FFRCT ≤ 0.80 non-revascularized. Early revascularization (< 90 days from index CTA) categorized vessels as revascularized. The primary endpoint comprised cardiovascular death and non-fatal myocardial infarction; the secondary endpoint vessel-specific late revascularization and non-fatal myocardial infarction., Results: Amongst 900 patients and 1759 vessels, FFRCT was ≤ 0.80 in 377 (42%) patients, 536 (30%) vessels; revascularization was performed in 244 (27%) patients, 340 (19%) vessels. Risk of the primary endpoint was higher for IR-FFRCT (15/210 [7.1%]) compared to CR-FFRCT (4/167 [2.4%]), RR: 2.98; 95% CI: 1.01-8.8, p = 0.036, and to normal FFRCT (3/523 [0.6%]), RR: 12.45; 95% CI: 3.6-42.6, p < 0.001. Incidence of the secondary endpoint was higher in non-revascularized vessels with FFRCT ≤ 0.80 (29/250 [12%]) compared to revascularized vessels with FFRCT ≤ 0.80 (5/286 [1.7%]), p = 0.001, and to vessels with FFRCT > 0.80 (10/1223 [0.8%]), p < 0.001., Conclusion: Incomplete revascularization of patients with lesion-specific FFRCT ≤ 0.80 is associated to unfavorable cardiovascular outcomes compared to those with complete revascularization or FFRCT > 0.80., Competing Interests: Declaration of competing interest CR is a full-time employee of HeartFlow, and receives salary and stock options from HeartFlow. ELG has no conflicts related to this manuscript but has received speaker honoraria or consultancy fees from AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Pfizer, Lundbeck Pharma, Novo Nordisk and Organon. He is investigator in clinical studies sponsored by AstraZeneca, Idorsia or Bayer and has received unrestricted research grants from Boehringer Ingelheim. JL is a consultant and holds stock options in Circle CVI and HeartFlow. KN acknowledges support from the NIH and reports unrestricted institutional research support from Siemens Healthineers, Bayer, HeartFlow Inc and Novartis. MP has received research grants from Janssen, Bayer, Heartflow and NIH and is part of the following advisory boards: Janssen, Bayer, Heartflow, Phillips. SM is a full-time employee of HeartFlow, and shareholder of HeartFlow. TF is associated with the HeartFlow speakers bureau. All other authors had no disclosures to declare., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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7. Influence of intensive lipid-lowering on CT derived fractional flow reserve in patients with stable chest pain: Rationale and design of the FLOWPROMOTE study.
- Author
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Mortensen MB, Sand NP, Busk M, Jensen JM, Grove EL, Dey D, Iraqi N, Updegrove A, Fonte T, Mathiassen ON, Hosbond S, Bøtker HE, Leipsic J, Narula J, and Nørgaard BL
- Subjects
- Atorvastatin, Ezetimibe therapeutic use, Humans, Predictive Value of Tests, Prospective Studies, Rosuvastatin Calcium, Severity of Illness Index, Tomography, X-Ray Computed, Angina, Stable, Fractional Flow Reserve, Myocardial, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Plaque, Atherosclerotic
- Abstract
Introduction: Coronary CT angiography (CTA) derived fractional flow reserve (FFR
CT ) shows high diagnostic performance when compared to invasively measured FFR. Presence and extent of low attenuation plaque density have been shown to be associated with abnormal physiology by measured FFR. Moreover, it is well established that statin therapy reduces the rate of plaque progression and results in morphology alterations underlying atherosclerosis. However, the interplay between lipid lowering treatment, plaque regression, and the coronary physiology has not previously been investigated., Aim: To test whether lipid lowering therapy is associated with significant improvement in FFRCT , and whether there is a dose-response relationship between lipid lowering intensity, plaque regression, and coronary flow recovery., Methods: Investigator driven, prospective, multicenter, randomized study of patients with stable angina, coronary stenosis ≥50% determined by clinically indicated first-line CTA, and FFRCT ≤ 0.80 in whom coronary revascularization was deferred. Patients are randomized to standard (atorvastatin 40 mg daily) or intensive (rosuvastatin 40 mg + ezetimibe 10 mg daily) lipid lowering therapy for 18 months. Coronary CTA scans with blinded coronary plaque and FFRCT analyses will be repeated after 9 and 18 months. The primary endpoint is the 18-month difference in FFRCT using (1) the FFRCT value 2 cm distal to stenosis and (2) the lowest distal value in the vessel of interest. A total of 104 patients will be included in the study., Conclusion: The results of this study will provide novel insights into the interplay between lipid lowering, and the pathophysiology in coronary artery disease., (© 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC.)- Published
- 2022
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8. [Sex of rearing in 46,XY partial gonadal dysgenesis (case report)].
- Author
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Iraqi N, Gaouzi A, and Bouhafs MA
- Subjects
- Cryptorchidism pathology, Gonadal Dysgenesis, 46,XY diagnosis, Gonadal Dysgenesis, 46,XY genetics, Humans, Hypospadias pathology, Infant, Male, Penis pathology, Phenotype, Gonadal Dysgenesis, 46,XY pathology, Sex Characteristics
- Abstract
XY patients with gonadal dysgenesis present with a wide array of clinical pictures that is characterised by a variable incomplete virilisation of the external genital organs (female phenotype, posterior hypospadias, cryptorchidism) and the persistence of the internal müllerian duct structures. The birth of a child with this type of abnormality is a social phenomenon, which will probably have a physical and psychical impact. The choice of the sex depends on the organic anatomy, diagnosis age, risk of gonadal tumors and the development possibilities (mainly at puberty) of the child. The registration of the civil status can be made only after determining the sex through the aforementioned anatomical and functional study. Once this process is finished, the treatment must be considered. We report our experience, particularly complicated in the choice of the sex of child, with an XY karyotype and partial gonadal dysgenesis. Raised as a girl until her seventh day when her parents noticed the existence of a genital bud and decided to register their child as a boy in the civil status. He was referred to our hospital, at the age of 16 months, in order to explore a bilateral cryptorchidism and posterior hypospadias. Our patient was declared to be a boy based on an unanimous opinion of a multidisciplinary team., (Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.)
- Published
- 2010
- Full Text
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