1. Randomized Controlled Trial of Bovine Lactoferrin for Prevention of Sepsis and Neurodevelopment Impairment in Infants Weighing Less Than 2000 Grams
- Author
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Theresa J. Ochoa, Jaime Zegarra, Sicilia Bellomo, Cesar P. Carcamo, Luis Cam, Anne Castañeda, Aasith Villavicencio, Jorge Gonzales, Maria S. Rueda, Christie G. Turin, Alonso Zea-Vera, Daniel Guillen, Miguel Campos, Linda Ewing-Cobbs, Pilar Medina, María Rivas, Irene Chea, Alicia Villar, Carolina Navarro, Lourdes Tucto, Patricia Mallma, Renzo Calderon-Anyosa, María Luz Rospigliosi, Geraldine Borda, Orialit Minauro, Verónica Webb, Erika Bravo, Karen Pacheco, Ana Lino, Augusto Cama, Raúl Llanos, Oscar Chumbes, Liliana Cuba, Julio Tresierra, Carmen Chincaro, and Alfredo Tori
- Subjects
First episode ,Pediatrics ,medicine.medical_specialty ,business.industry ,Incidence (epidemiology) ,Birth weight ,Hazard ratio ,medicine.disease ,Placebo ,law.invention ,Sepsis ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,030225 pediatrics ,Pediatrics, Perinatology and Child Health ,Bovine lactoferrin ,medicine ,030212 general & internal medicine ,business - Abstract
Objectives To determine the effect of bovine lactoferrin on prevention of late-onset sepsis (LOS) and neurodevelopment delay. Study design Randomized, double-blind, controlled trial in neonates with a birth weight of 500-2000 g in 3 neonatal units in Lima, Peru, comparing bovine lactoferrin 200 mg/kg/day with placebo administered for 8 weeks. The primary outcome was the first episode of culture-proven LOS or sepsis-associated death. Neurodevelopment delay was assessed by the Mullen Scales at 24 months corrected age. Results Of the 414 infants enrolled, 209 received bovine lactoferrin and 205 received placebo. LOS or sepsis-associated death occurred in 22 infants (10.5%) in the bovine lactoferrin group vs 30 (14.6%) in the placebo group; there was no difference after adjusting for hospital and birth weight; hazard ratio 0.73 (95% CI, 0.42-1.26). For infants with birth weights of Conclusions Supplementation with bovine lactoferrin did not decrease the incidence of sepsis in infants with birth weights of Trial registration ClinicalTrials.gov : NCT01525316 .
- Published
- 2020
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