1. Thrombospondin 1 and Nuclear Factor Kappa B Signaling Pathways in Non-alcoholic Fatty Liver Disease
- Author
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Omur Tabak, Murat Akarsu, Irem Kirac Utku, Hanise Ozkan, Ahmet Cinar, Mitat Buyukkaba, Isa Yalcinkaya, Gulden Anataca, Hafize Uzun, Seyma Dumur, and Iskender Ekinci
- Subjects
Thrombospondin 1 ,Glucose ,Non-alcoholic Fatty Liver Disease ,Gastroenterology ,NF-kappa B ,Humans ,Alanine Transaminase ,Aspartate Aminotransferases ,Signal Transduction - Abstract
Aim: We aimed to evaluate the circulating thrombospondin-1 (TSP-1) and nuclear factor kappa B (NF-κB) in nonalcoholic fatty liver disease (NAFLD) in order to integrate these signaling pathways in the inflammatory and fibrogenic processes of this liver disorder. Methods: Ninety-five NAFLD patients were recruited in the study. The study also included 83 age-sex matched healthy controls. Results: The number of patients with metabolic syndrome (MetS) criteria was 57 (60%). TSP-1 level was found to be statistically significantly lower in the NAFLD group compared to the control group (p=0.037). However, NF-κB level was found to be significantly higher in the NAFLD group compared to the control group (p=0.004). There was a significant negative correlation between plasma TSP-1 levels with glucose (r=-0.235, p=0.022), alanine aminotransferase (r=-0.261, p=0.011) and aspartate transaminase (r=-0.328, p=0.001) levels. In addition, a significant negative correlation was found between plasma TSP-1 and NF-κB levels (r=-0.729, p
- Published
- 2022