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4. A novel role for nucleolin in splice site selection

Author

Shefer, Kinneret, primary, Boulos, Ayub, additional, Gotea, Valer, additional, Arafat, Maram, additional, Ben Chaim, Yair, additional, Muharram, Aya, additional, Isaac, Sara, additional, Eden, Amir, additional, Sperling, Joseph, additional, Elnitski, Laura, additional, and Sperling, Ruth, additional

Published
2022
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6. Interaction of Epel with the heterochromatin assembly pathway in Schizosaccharomyces pombe

Author

Isaac, Sara, Walfridsson, Julian, Zohar, Tal, Lazar, David, Kahan, Tamar, Ekwall, Karl, and Cohen, Amikam

Subjects
Gene expression -- Research, Biological sciences
Abstract

Epel is a JmjC domain protein that antagonizes heterochromatization in Schizosaccharomyces pombe. Related JmjC domain proteins catalyze a histone demethylation reaction that depends on Fe(II) and [alpha]-ketoglutarate. However, no detectable demethylase activity is associated with Epel, and itsJmjC domain lacks conservation of Fe(II)-binding residues. We report that Swi6 recruits Epel to heterochromatin and that overexpression of [pepe1.sup.+], like mutations in silencing genes or overexpression of [swi6.sup.+], upregulates expression of certain genes. A significant overlap was observed between the lists of genes that are upregulated by overexpression of [epe1.sup.+] and those that are upregulated by mutations in histone deacetylase genes. However, most of the common genes are not regulated by Clr4 histone methyltransferase. This suggests that Epel interacts with the heterochromatin assembly pathway at the stage of histone deacetylation. Mutational inactivation of Epel downregulates ~12% of S. pombe genes, and the list of these genes overlaps significantly with the lists of genes that are upregulated by mutations in silencing genes and genes that are hyperacetylated at their promoter regions in clr6-1 mutants. We propose that an interplay between the repressive HDACs activity and Epel helps to regulate gene expression in S. pombe.

Published
2007

18. `Ordinary Life' by Elizabeth Berg; Random House, $24.95, 192 pages)

Author

Isaac, Sara

Subjects
General interest, News, opinion and commentary
Abstract

At her best, Elizabeth Berg is an impassioned portrayer of the rich and complex tapestry woven by the commonplace interactions of unremarkable people living out everyday lives. 'Ordinary Life,' her [...]

Published
2002

19. `The Hallelujah Side,' by Rhoda Huffey; Mariner Books

Author

Isaac, Sara

Subjects
General interest, News, opinion and commentary
Abstract

More than anything, Roxanne Fish wants to be saved. The daughter of an Assembly of God preacher and a dreamy, passionate mother who crackles with physical faith, Roxanne has felt [...]

Published
2001

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