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1. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families

Author

Bailey-Wilson Joan E, Childs Erica J, Cropp Cheryl D, Schaid Daniel J, Xu Jianfeng, Camp Nicola J, Cannon-Albright Lisa A, Farnham James M, George Asha, Powell Isaac, Carpten John D, Giles Graham G, Hopper John L, Severi Gianluca, English Dallas R, Foulkes William D, Mæhle Lovise, Møller Pål, Eeles Rosalind, Easton Douglas, Guy Michelle, Edwards Steve, Badzioch Michael D, Whittemore Alice S, Oakley-Girvan Ingrid, Hsieh Chih-Lin, Dimitrov Latchezar, Stanford Janet L, Karyadi Danielle M, Deutsch Kerry, McIntosh Laura, Ostrander Elaine A, Wiley Kathleen E, Isaacs Sarah D, Walsh Patrick C, Thibodeau Stephen N, McDonnell Shannon K, Hebbring Scott, Lange Ethan M, Cooney Kathleen A, Tammela Teuvo LJ, Schleutker Johanna, Maier Christiane, Bochum Sylvia, Hoegel Josef, Grönberg Henrik, Wiklund Fredrik, Emanuelsson Monica, Cancel-Tassin Geraldine, Valeri Antoine, Cussenot Olivier, and Isaacs William B

Subjects
Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Genetic variants are likely to contribute to a portion of prostate cancer risk. Full elucidation of the genetic etiology of prostate cancer is difficult because of incomplete penetrance and genetic and phenotypic heterogeneity. Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive. Methods Parametric and non-parametric linkage analyses were performed using 26 microsatellite markers in each of 11 groups of multiple-case prostate cancer families from the International Consortium for Prostate Cancer Genetics (ICPCG). Meta-analyses of the resultant family-specific linkage statistics across the entire 1,323 families and in several predefined subsets were then performed. Results Meta-analyses of linkage statistics resulted in a maximum parametric heterogeneity lod score (HLOD) of 1.28, and an allele-sharing lod score (LOD) of 2.0 in favor of linkage to Xq27-q28 at 138 cM. In subset analyses, families with average age at onset less than 65 years exhibited a maximum HLOD of 1.8 (at 138 cM) versus a maximum regional HLOD of only 0.32 in families with average age at onset of 65 years or older. Surprisingly, the subset of families with only 2–3 affected men and some evidence of male-to-male transmission of prostate cancer gave the strongest evidence of linkage to the region (HLOD = 3.24, 134 cM). For this subset, the HLOD was slightly increased (HLOD = 3.47 at 134 cM) when families used in the original published report of linkage to Xq27-28 were excluded. Conclusions Although there was not strong support for linkage to the Xq27-28 region in the complete set of families, the subset of families with earlier age at onset exhibited more evidence of linkage than families with later onset of disease. A subset of families with 2–3 affected individuals and with some evidence of male to male disease transmission showed stronger linkage signals. Our results suggest that the genetic basis for prostate cancer in our families is much more complex than a single susceptibility locus on the X chromosome, and that future explorations of the Xq27-28 region should focus on the subset of families identified here with the strongest evidence of linkage to this region.

Published
2012
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3. Supplementary Table 3 from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Author

Prokunina-Olsson, Ludmila, primary, Fu, Yi-Ping, primary, Tang, Wei, primary, Jacobs, Kevin B., primary, Hayes, Richard B., primary, Kraft, Peter, primary, Berndt, Sonja I., primary, Wacholder, Sholom, primary, Yu, Kai, primary, Hutchinson, Amy, primary, Spencer Feigelson, Heather, primary, Thun, Michael J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie, primary, Schumacher, Fredrick R., primary, Cancel-Tassin, Geraldine, primary, Cussenot, Olivier, primary, Valeri, Antoine, primary, Andriole, Gerald L., primary, Crawford, E. David, primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, Kolonel, Laurence, primary, Le Marchand, Loic, primary, Siddiq, Afshan, primary, Riboli, Elio, primary, Travis, Ruth, primary, Kaaks, Rudolf, primary, Isaacs, William B., primary, Isaacs, Sarah D., primary, Grönberg, Henrik, primary, Wiklund, Fredrik, primary, Xu, Jianfeng, primary, Vatten, Lars J., primary, Hveem, Kristian, primary, Kumle, Merethe, primary, Tucker, Margaret, primary, Hoover, Robert N., primary, Fraumeni, Joseph F., primary, Hunter, David J., primary, Thomas, Gilles, primary, Chatterjee, Nilanjan, primary, Chanock, Stephen J., primary, and Yeager, Meredith, primary

Published
2023
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4. Supplementary Table 2A from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Author

Prokunina-Olsson, Ludmila, primary, Fu, Yi-Ping, primary, Tang, Wei, primary, Jacobs, Kevin B., primary, Hayes, Richard B., primary, Kraft, Peter, primary, Berndt, Sonja I., primary, Wacholder, Sholom, primary, Yu, Kai, primary, Hutchinson, Amy, primary, Spencer Feigelson, Heather, primary, Thun, Michael J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie, primary, Schumacher, Fredrick R., primary, Cancel-Tassin, Geraldine, primary, Cussenot, Olivier, primary, Valeri, Antoine, primary, Andriole, Gerald L., primary, Crawford, E. David, primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, Kolonel, Laurence, primary, Le Marchand, Loic, primary, Siddiq, Afshan, primary, Riboli, Elio, primary, Travis, Ruth, primary, Kaaks, Rudolf, primary, Isaacs, William B., primary, Isaacs, Sarah D., primary, Grönberg, Henrik, primary, Wiklund, Fredrik, primary, Xu, Jianfeng, primary, Vatten, Lars J., primary, Hveem, Kristian, primary, Kumle, Merethe, primary, Tucker, Margaret, primary, Hoover, Robert N., primary, Fraumeni, Joseph F., primary, Hunter, David J., primary, Thomas, Gilles, primary, Chatterjee, Nilanjan, primary, Chanock, Stephen J., primary, and Yeager, Meredith, primary

Published
2023
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5. Supplementary Tables S6 and S7 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer

Author

Hurley, Paula J., primary, Sundi, Debasish, primary, Shinder, Brian, primary, Simons, Brian W., primary, Hughes, Robert M., primary, Miller, Rebecca M., primary, Benzon, Benjamin, primary, Faraj, Sheila F., primary, Netto, George J., primary, Vergara, Ismael A., primary, Erho, Nicholas, primary, Davicioni, Elai, primary, Karnes, R. Jeffrey, primary, Yan, Guifang, primary, Ewing, Charles, primary, Isaacs, Sarah D., primary, Berman, David M., primary, Rider, Jennifer R., primary, Jordahl, Kristina M., primary, Mucci, Lorelei A., primary, Huang, Jessie, primary, An, Steven S., primary, Park, Ben H., primary, Isaacs, William B., primary, Marchionni, Luigi, primary, Ross, Ashley E., primary, and Schaeffer, Edward M., primary

Published
2023
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6. Supplementary Table 1 from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Author

Prokunina-Olsson, Ludmila, primary, Fu, Yi-Ping, primary, Tang, Wei, primary, Jacobs, Kevin B., primary, Hayes, Richard B., primary, Kraft, Peter, primary, Berndt, Sonja I., primary, Wacholder, Sholom, primary, Yu, Kai, primary, Hutchinson, Amy, primary, Spencer Feigelson, Heather, primary, Thun, Michael J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie, primary, Schumacher, Fredrick R., primary, Cancel-Tassin, Geraldine, primary, Cussenot, Olivier, primary, Valeri, Antoine, primary, Andriole, Gerald L., primary, Crawford, E. David, primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, Kolonel, Laurence, primary, Le Marchand, Loic, primary, Siddiq, Afshan, primary, Riboli, Elio, primary, Travis, Ruth, primary, Kaaks, Rudolf, primary, Isaacs, William B., primary, Isaacs, Sarah D., primary, Grönberg, Henrik, primary, Wiklund, Fredrik, primary, Xu, Jianfeng, primary, Vatten, Lars J., primary, Hveem, Kristian, primary, Kumle, Merethe, primary, Tucker, Margaret, primary, Hoover, Robert N., primary, Fraumeni, Joseph F., primary, Hunter, David J., primary, Thomas, Gilles, primary, Chatterjee, Nilanjan, primary, Chanock, Stephen J., primary, and Yeager, Meredith, primary

Published
2023
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7. Supplementary Table Legends from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Author

Prokunina-Olsson, Ludmila, primary, Fu, Yi-Ping, primary, Tang, Wei, primary, Jacobs, Kevin B., primary, Hayes, Richard B., primary, Kraft, Peter, primary, Berndt, Sonja I., primary, Wacholder, Sholom, primary, Yu, Kai, primary, Hutchinson, Amy, primary, Spencer Feigelson, Heather, primary, Thun, Michael J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie, primary, Schumacher, Fredrick R., primary, Cancel-Tassin, Geraldine, primary, Cussenot, Olivier, primary, Valeri, Antoine, primary, Andriole, Gerald L., primary, Crawford, E. David, primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, Kolonel, Laurence, primary, Le Marchand, Loic, primary, Siddiq, Afshan, primary, Riboli, Elio, primary, Travis, Ruth, primary, Kaaks, Rudolf, primary, Isaacs, William B., primary, Isaacs, Sarah D., primary, Grönberg, Henrik, primary, Wiklund, Fredrik, primary, Xu, Jianfeng, primary, Vatten, Lars J., primary, Hveem, Kristian, primary, Kumle, Merethe, primary, Tucker, Margaret, primary, Hoover, Robert N., primary, Fraumeni, Joseph F., primary, Hunter, David J., primary, Thomas, Gilles, primary, Chatterjee, Nilanjan, primary, Chanock, Stephen J., primary, and Yeager, Meredith, primary

Published
2023
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8. Data from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2

Author

Prokunina-Olsson, Ludmila, primary, Fu, Yi-Ping, primary, Tang, Wei, primary, Jacobs, Kevin B., primary, Hayes, Richard B., primary, Kraft, Peter, primary, Berndt, Sonja I., primary, Wacholder, Sholom, primary, Yu, Kai, primary, Hutchinson, Amy, primary, Spencer Feigelson, Heather, primary, Thun, Michael J., primary, Diver, W. Ryan, primary, Albanes, Demetrius, primary, Virtamo, Jarmo, primary, Weinstein, Stephanie, primary, Schumacher, Fredrick R., primary, Cancel-Tassin, Geraldine, primary, Cussenot, Olivier, primary, Valeri, Antoine, primary, Andriole, Gerald L., primary, Crawford, E. David, primary, Haiman, Christopher A., primary, Henderson, Brian E., primary, Kolonel, Laurence, primary, Le Marchand, Loic, primary, Siddiq, Afshan, primary, Riboli, Elio, primary, Travis, Ruth, primary, Kaaks, Rudolf, primary, Isaacs, William B., primary, Isaacs, Sarah D., primary, Grönberg, Henrik, primary, Wiklund, Fredrik, primary, Xu, Jianfeng, primary, Vatten, Lars J., primary, Hveem, Kristian, primary, Kumle, Merethe, primary, Tucker, Margaret, primary, Hoover, Robert N., primary, Fraumeni, Joseph F., primary, Hunter, David J., primary, Thomas, Gilles, primary, Chatterjee, Nilanjan, primary, Chanock, Stephen J., primary, and Yeager, Meredith, primary

Published
2023
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9. Supplementary Figure S1 from Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer

Author

Hurley, Paula J., primary, Sundi, Debasish, primary, Shinder, Brian, primary, Simons, Brian W., primary, Hughes, Robert M., primary, Miller, Rebecca M., primary, Benzon, Benjamin, primary, Faraj, Sheila F., primary, Netto, George J., primary, Vergara, Ismael A., primary, Erho, Nicholas, primary, Davicioni, Elai, primary, Karnes, R. Jeffrey, primary, Yan, Guifang, primary, Ewing, Charles, primary, Isaacs, Sarah D., primary, Berman, David M., primary, Rider, Jennifer R., primary, Jordahl, Kristina M., primary, Mucci, Lorelei A., primary, Huang, Jessie, primary, An, Steven S., primary, Park, Ben H., primary, Isaacs, William B., primary, Marchionni, Luigi, primary, Ross, Ashley E., primary, and Schaeffer, Edward M., primary

Published
2023
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10. Supplementary Figure 1 from Germ-Line Mutation of NKX3.1 Cosegregates with Hereditary Prostate Cancer and Alters the Homeodomain Structure and Function

Author

Zheng, S. Lilly, primary, Ju, Jeong-ho, primary, Chang, Bao-li, primary, Ortner, Elizabeth, primary, Sun, Jielin, primary, Isaacs, Sarah D., primary, Sun, Jishang, primary, Wiley, Kathy E., primary, Liu, Wennuan, primary, Zemedkun, Micheas, primary, Walsh, Patrick C., primary, Ferretti, James, primary, Gruschus, James, primary, Isaacs, William B., primary, Gelmann, Edward P., primary, and Xu, Jianfeng, primary

Published
2023
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11. Supplementary Figure 1 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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12. Supplementary Table 3 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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13. Data from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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14. Data from Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer

Author

Liu, Wennuan, primary, Sun, Jishan, primary, Li, Ge, primary, Zhu, Yi, primary, Zhang, Scott, primary, Kim, Seong-Tae, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Wiley, Kathleen, primary, Isaacs, Sarah D., primary, Stattin, Pär, primary, Xu, Jianfeng, primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Zheng, S. Lilly, primary, and Chang, Bao-Li, primary

Published
2023
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15. Supplementary Table 2 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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16. Supplementary Figure 1 from Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer

Author

Liu, Wennuan, primary, Sun, Jishan, primary, Li, Ge, primary, Zhu, Yi, primary, Zhang, Scott, primary, Kim, Seong-Tae, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Wiley, Kathleen, primary, Isaacs, Sarah D., primary, Stattin, Pär, primary, Xu, Jianfeng, primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Zheng, S. Lilly, primary, and Chang, Bao-Li, primary

Published
2023
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17. Supplementary Figure 2 from Association of a Germ-Line Copy Number Variation at 2p24.3 and Risk for Aggressive Prostate Cancer

Author

Liu, Wennuan, primary, Sun, Jishan, primary, Li, Ge, primary, Zhu, Yi, primary, Zhang, Scott, primary, Kim, Seong-Tae, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Wiley, Kathleen, primary, Isaacs, Sarah D., primary, Stattin, Pär, primary, Xu, Jianfeng, primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Zheng, S. Lilly, primary, and Chang, Bao-Li, primary

Published
2023
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18. Data from Sequence Variants at 22q13 Are Associated with Prostate Cancer Risk

Author

Sun, Jielin, primary, Zheng, Siqun Lilly, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Li, Ge, primary, Wiley, Kathleen E., primary, Kim, Seong-Tae, primary, Zhu, Yi, primary, Zhang, Zheng, primary, Hsu, Fang-Chi, primary, Turner, Aubrey R., primary, Stattin, Pär, primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Duggan, David, primary, Carpten, John, primary, Isaacs, William, primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Chang, Bao-Li, primary

Published
2023
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19. Supplementary Table 4 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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20. Supplementary Table 1 from A Novel Prostate Cancer Susceptibility Locus at 19q13

Author

Hsu, Fang-Chi, primary, Sun, Jielin, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Wiley, Kathleen E., primary, Purcell, Lina D., primary, Gao, Zhengrong, primary, Stattin, Pär, primary, Zhu, Yi, primary, Kim, Seong-Tae, primary, Zhang, Zheng, primary, Liu, Wennuan, primary, Chang, Bao-Li, primary, Walsh, Patrick C., primary, Duggan, David, primary, Carpten, John D., primary, Isaacs, William B., primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Zheng, S. Lilly, primary

Published
2023
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21. Supplementary Methods, Tables and Figures from Sequence Variants at 22q13 Are Associated with Prostate Cancer Risk

Author

Sun, Jielin, primary, Zheng, Siqun Lilly, primary, Wiklund, Fredrik, primary, Isaacs, Sarah D., primary, Li, Ge, primary, Wiley, Kathleen E., primary, Kim, Seong-Tae, primary, Zhu, Yi, primary, Zhang, Zheng, primary, Hsu, Fang-Chi, primary, Turner, Aubrey R., primary, Stattin, Pär, primary, Liu, Wennuan, primary, Kim, Jin Woo, primary, Duggan, David, primary, Carpten, John, primary, Isaacs, William, primary, Grönberg, Henrik, primary, Xu, Jianfeng, primary, and Chang, Bao-Li, primary

Published
2023
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22. Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

Author

Smith, Jeffrey R., Freije, Diha, Carpten, John D., Grönberg, Henrik, Xu, Jianfeng, Isaacs, Sarah D., Brownstein, Michael J., Bova, G. Steven, Guo, Hong, Bujnovszky, Piroska, Nusskern, Deborah R., Damber, Jan-Erik, Bergh, Anders, Emanuelsson, Monika, Kallioniemi, Olli P., Walker-Daniels, Jennifer, Bailey-Wilson, Joan E., Beaty, Terri H., Meyers, Deborah A., Walsh, Patrick C., Collins, Francis S., Trent, Jeffrey M., and Isaacs, William B.

Published
1996

23. Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21

Author

Teerlink, Craig C., Leongamornlert, Daniel, Dadaev, Tokhir, Thomas, Alun, Farnham, James, Stephenson, Robert A., Riska, Shaun, McDonnell, Shannon K., Schaid, Daniel J., Catalona, William J., Zheng, S. Lilly, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., Giles, Graham G., Southey, Melissa C., Fitzgerald, Liesel M., Rinckleb, Antje, Luedeke, Manuel, Maier, Christiane, Stanford, Janet L., Ostrander, Elaine A., Kaikkonen, Elina M., Sipeky, Csilla, Tammela, Teuvo, Schleutker, Johanna, Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Xu, Jianfeng, Cancel-Tassin, Geraldine, Cussenot, Olivier, Mandal, Diptasri, Laurie, Cecelia, Laurie, Cathy, Thibodeau, Stephen N., Eeles, Rosalind A., Kote-Jarai, Zsofia, Cannon-Albright, Lisa, The PRACTICAL consortium, and International Consortium for Prostate Cancer Genetics

Published
2016
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25. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease

Author

Teerlink, Craig C., Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Rinckleb, Antje, Maier, Christiane, Vogel, Walther, Cancel-Tassin, Geraldine, Egrot, Christophe, Cussenot, Olivier, Foulkes, William D., Giles, Graham G., Hopper, John L., Severi, Gianluca, Eeles, Ros, Easton, Douglas, Kote-Jarai, Zsofia, Guy, Michelle, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., FitzGerald, Liesel M., Stanford, Janet L., Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Wahlfors, Tiina, Tammela, Teuvo, Schleutker, Johanna, Wiklund, Fredrik, Grönberg, Henrik, Emanuelsson, Monica, Carpten, John, Bailey-Wilson, Joan, Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Catalona, William J., Zheng, S. Lilly, Jin, Guangfu, Lu, Lingyi, Xu, Jianfeng, Camp, Nicola J., Cannon-Albright, Lisa A., and International Consortium for Prostate Cancer Genetics

Published
2014
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26. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG)

Author

Xu, Jianfeng, Lange, Ethan M., Lu, Lingyi, Zheng, Siqun L., Wang, Zhong, Thibodeau, Stephen N., Cannon-Albright, Lisa A., Teerlink, Craig C., Camp, Nicola J., Johnson, Anna M., Zuhlke, Kimberly A., Stanford, Janet L., Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Maier, Christiane, Luedeke, Manuel, Vogel, Walther, Schleutker, Johanna, Wahlfors, Tiina, Tammela, Teuvo, Schaid, Daniel, McDonnell, Shannon K., DeRycke, Melissa S., Cancel-Tassin, Geraldine, Cussenot, Olivier, Wiklund, Fredrik, Grönberg, Henrik, Eeles, Ros, Easton, Doug, Kote-Jarai, Zsofia, Whittemore, Alice S., Hsieh, Chih-Lin, Giles, Graham G., Hopper, John L., Severi, Gianluca, Catalona, William J., Mandal, Diptasri, Ledet, Elisa, Foulkes, William D., Hamel, Nancy, Mahle, Lovise, Moller, Pal, Powell, Isaac, Bailey-Wilson, Joan E., Carpten, John D., Seminara, Daniela, Cooney, Kathleen A., Isaacs, William B., and International Consortium for Prostate Cancer Genetics

Published
2013
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27. Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG)

Author

Jin, Guangfu, Lu, Lingyi, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., Cannon-Albright, Lisa A., Camp, Nicola J., Teerlink, Craig C., FitzGerald, Liesel M., Stanford, Janet L., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Foulkes, William D., Giles, Graham G., Hopper, John L., Severi, Gianluca, Eeles, Ros, Easton, Doug, Kote-Jarai, Zsofia, Guy, Michelle, Rinckleb, Antje, Maier, Christiane, Vogel, Walther, Cancel-Tassin, Geraldine, Egrot, Christophe, Cussenot, Olivier, Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Wiklund, Fredrik, Grönberg, Henrik, Emanuelsson, Monica, Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Wahlfors, Tiina, Tammela, Teuvo, Schleutker, Johanna, Catalona, William J., Zheng, S. Lilly, Ostrander, Elaine A., Isaacs, William B., Xu, Jianfeng, and International Consortium for Prostate Cancer Genetics

Published
2012
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29. Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect

Author

Chang, Bao-Li, Lange, Ethan M., Dimitrov, Latchezar, Valis, Christopher J., Gillanders, Elizabeth M., Lange, Leslie A., Wiley, Kathleen E., Isaacs, Sarah D., Wiklund, Fredrik, Baffoe-Bonnie, Agnes, Langefeld, Carl D, Zheng, S. Lilly, Matikainen, Mika P., Ikonen, Tarja, Fredriksson, Henna, Tammela, Teuvo, Walsh, Patrick C., Bailey-Wilson, Joan E., Schleutker, Johanna, Gronberg, Henrik, Cooney, Kathleen A., Isaacs, William B., Suh, Edward, Trent, Jeffrey M., and Xu, Jianfeng

Published
2006
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31. A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the International Consortium for Prostate Cancer Genetics

Author

Xu, Jianfeng, Dimitrov, Latchezar, Chang, Bao-Li, Adams, Tamara S., Turner, Aubrey R., Meyers, Deborah A., Eeles, Rosalind A., Easton, Douglas F., Foulkes, William D., Simard, Jacques, Giles, Graham G., Hopper, John L., Mahle, Lovise, Moller, Pal, Bishop, Tim, Evans, Chris, Edwards, Steve, Meitz, Julia, Bullock, Sarah, Hope, Questa, Hsieh, Chih-lin, Halpern, Jerry, Balise, Raymond N., Oakley-Girvan, Ingrid, Whittemore, Alice S., Ewing, Charles M., Gielzak, Marta, Isaacs, Sarah D., Walsh, Patrick C., Wiley, Kathleen E., Isaacs, William B., Thibodeau, Stephen N., McDonnell, Shannon K., Cunningham, Julie M., Zarfas, Katherine E., Hebbring, Scott, Schaid, Daniel J., Friedrichsen, Danielle M., Deutsch, Kerry, Kolb, Suzanne, Badzioch, Michael, Jarvik, Gail P., Janer, Marta, Hood, Leroy, Ostrander, Elaine A., Stanford, Janet L., Lange, Ethan M., Beebe-Dimmer, Jennifer L., Mohai, Caroline E., Cooney, Kathleen A., Ikonen, Tarja, Baffoe-Bonnie, Agnes, Fredriksson, Henna, Matikainen, Mika P., Tammela, Teuvo LJ, Bailey-Wilson, Joan, Schleutker, Johanna, Maier, Christiane, Herkommer, Kathleen, Hoegel, Josef J., Vogel, Walther, Paiss, Thomas, Wiklund, Fredrik, Emanuelsson, Monica, Stenman, Elisabeth, Jonsson, Bjorn-Anders, Gronberg, Henrik, Camp, Nicola J., Farnham, James, Cannon-Albright, Lisa A., and Seminara, Daniela

Subjects
Prostate cancer -- Genetic aspects, Human genetics -- Research, Biological sciences
Published
2005

34. Linkage of prostate cancer susceptibility loci to chromosome 1

Author

Xu, Jianfeng, Zheng, Siqun L., Chang, Bao-li, Smith, Jeffrey R., Carpten, John D., Stine, O. Colin, Isaacs, Sarah D., Wiley, Kathy E., Henning, Lauren, Ewing, Charles, Bujnovszky, Piroska, Bleeker, Eugene R., Walsh, Patrick C., Trent, Jeffrey M., Meyers, Deborah A., and Isaacs, William B.

Published
2001
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35. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG

Author

Lu, Lingyi, Cancel-Tassin, Geraldine, Valeri, Antoine, Cussenot, Olivier, Lange, Ethan M., Cooney, Kathleen A., Farnham, James M., Camp, Nicola J., Cannon-Albright, Lisa A., Tammela, Teuvo L.J., Schleutker, Johanna, Hoegel, Josef, Herkommer, Kathleen, Maier, Christiane, Vogel, Walther, Wiklund, Fredrik, Emanuelsson, Monica, Grönberg, Henrik, Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Helfand, Brian T., Kan, Donghui, Catalona, William J., Stanford, Janet L., FitzGerald, Liesel M., Johanneson, Bo, Deutsch, Kerry, McIntosh, Laura, Ostrander, Elaine A., Thibodeau, Stephen N., McDonnell, Shannon K., Hebbring, Scott, Schaid, Daniel J., Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Powell, Isaac, Bailey-Wilson, Joan E., Cropp, Cheryl D., Simpson, Claire, Carpten, John D., Seminara, Daniela, Zheng, Lilly S., Xu, Jianfen, Giles, Graham G., Severi, Gianluca, Hopper, John L., English, Dallas R., Foulkes, William D., Maehle, Lovise, Moller, Pal, Badzioch, Michael D., Edwards, Steve, Guy, Michelle, Eeles, Ros, Easton, Douglas, and Isaacs, William B.

Published
2012
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36. Germline Mutations in HOXB13 and Prostate-Cancer Risk

Author

Ewing, Charles M., Ray, Anna M., Lange, Ethan M., Zuhlke, Kimberly A., Robbins, Christiane M., Tembe, Waibhav D., Wiley, Kathleen E., Isaacs, Sarah D., Johng, Dorhyun, Wang, Yunfei, Bizon, Chris, Yan, Guifang, Gielzak, Marta, Partin, Alan W., Shanmugam, Vijayalakshmi, Izatt, Tyler, Sinari, Shripad, Craig, David W., Zheng, Lilly S., Walsh, Patrick C., Montie, James E., Xu, Jianfeng, Carpten, John D., Isaacs, William B., and Cooney, Kathleen A.

Published
2012
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38. Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer

Author

Chung, Charles C., Ciampa, Julia, Yeager, Meredith, Jacobs, Kevin B, Berndt, Sonja I., Hayes, Richard B., Gonzalez-Bosquet, Jesus, Kraft, Peter, Wacholder, Sholom, Orr, Nick, Yu, Kai, Hutchinson, Amy, Boland, Joseph, Chen, Quan, Feigelson, Heather Spencer, Thun, Michael J., Diver, W. Ryan, Albanes, Demetrius, Virtamo, Jarmo, Weinstein, Stephanie, Schumacher, Fredrick R., Cancel-Tassin, Geraldine, Cussenot, Olivier, Valeri, Antoine, Andriole, Gerald L., Crawford, E. David, Haiman, Christopher A., Henderson, Brian E., Kolonel, Laurence, Le Marchand, Loic, Siddiq, Afshan, Riboli, Elio, Key, Tim J., Kaaks, Rudolf, Isaacs, William B., Isaacs, Sarah D., Grönberg, Henrik, Wiklund, Fredrik, Xu, Jianfeng, Vatten, Lars J., Hveem, Kristian, Njolstad, Inger, Gerhard, Daniela S., Tucker, Margaret, Hoover, Robert N., Fraumeni, Joseph F., Jr, Hunter, David J., Thomas, Gilles, Chatterjee, Nilanjan, and Chanock, Stephen J.

Published
2011
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39. Genome-Wide Linkage Analysis of 1,233 Prostate Cancer Pedigrees From the International Consortium for Prostate Cancer Genetics Using Novel sum LINK and sum LOD Analyses

Author

Christensen, Bryce G., Baffoe-Bonnie, Agnes B., George, Asha, Powell, Isaac, Bailey-Wilson, Joan E., Carpten, John D., Giles, Graham G., Hopper, John L., Severi, Gianluca, English, Dallas R., Foulkes, William D., Maehle, Lovise, Moller, Pal, Eeles, Ros, Easton, Douglas, Badzioch, Michael D., Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Dimitrov, Latchezar, Xu, Jianfeng, Stanford, Janet L., Johanneson, Bo, Deutsch, Kerry, McIntosh, Laura, Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Thibodeau, Stephen N., McDonnell, Shannon K., Hebbring, Scott, Schaid, Daniel J., Lange, Ethan M., Cooney, Kathleen A., Tammela, Teuvo L.J., Schleutker, Johanna, Paiss, Thomas, Maier, Christiane, Grönberg, Henrik, Wiklund, Fredrik, Emanuelsson, Monica, Farnham, James M., Cannon-Albright, Lisa A., and Camp, Nicola J.

Published
2010
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41. Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk

Author

Chang, Bao-Li, Cramer, Scott D., Wiklund, Fredrik, Isaacs, Sarah D., Stevens, Victoria L., Sun, Jielin, Smith, Shelly, Pruett, Kristen, Romero, Lina M., Wiley, Kathleen E., Kim, Seong-Tae, Zhu, Yi, Zhang, Zheng, Hsu, Fang-Chi, Turner, Aubrey R., Adolfsson, Jan, Liu, Wennuan, Kim, Jin Woo, Duggan, David, Carpten, John, Zheng, S Lilly, Rodriguez, Carmen, Isaacs, William B., Grönberg, Henrik, and Xu, Jianfeng

Published
2009

45. Two Genome-wide Association Studies of Aggressive Prostate Cancer Implicate Putative Prostate Tumor Suppressor Gene DAB2IP

Author

Duggan, David, Zheng, Siqun L., Knowlton, Michele, Benitez, Debbie, Dimitrov, Latchezar, Wiklund, Fredrik, Robbins, Christiane, Isaacs, Sarah D., Cheng, Yu, Li, Ge, Sun, Jielin, Chang, Bao-Li, Marovich, Leslie, Wiley, Kathleen E., Bälter, Katarina, Stattin, Pär, Adami, Hans-Olov, Gielzak, Marta, Yan, Guifang, Sauvageot, Jurga, Liu, Wennuan, Kim, Jin Woo, Bleecker, Eugene R., Meyers, Deborah A., Trock, Bruce J., Partin, Alan W., Walsh, Patrick C., Isaacs, William B., Grönberg, Henrik, Xu, Jianfeng, and Carpten, John D.

Published
2007

46. Association Between Two Unlinked Loci at 8q24 and Prostate Cancer Risk Among European Americans

Author

Zheng, S. Lilly, Sun, Jielin, Cheng, Yu, Li, Ge, Hsu, Fang-Chi, Zhu, Yi, Chang, Bao-Li, Liu, Wennuan, Kim, Jin Woo, Turner, Aubrey R., Gielzak, Marta, Yan, Guifang, Isaacs, Sarah D., Wiley, Kathleen E., Sauvageot, Jurga, Chen, Huann-Sheng, Gurganus, Robin, Mangold, Leslie A., Trock, Bruce J., Gronberg, Henrik, Duggan, David, Carpten, John D., Partin, Alan W., Walsh, Patrick C., Xu, Jianfeng, and Isaacs, William B.

Published
2007

47. Compelling evidence for a prostate cancer gene at 22q12.3 by the International Consortium for Prostate Cancer Genetics

Author

Camp, Nicola J., Cannon-Albright, Lisa A., Farnham, James M., Baffoe-Bonnie, Agnes B., George, Asha, Powell, Isaac, Bailey-Wilson, Joan E., Carpten, John D., Giles, Graham G., Hopper, John L., Severi, Gianluca, English, Dallas R., Foulkes, William D., Maehle, Lovise, Moller, Pal, Eeles, Ros, Easton, Douglas, Badzioch, Michael D., Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Dimitrov, Latchezar, Xu, Jianfeng, Stanford, Janet L., Johanneson, Bo, Deutsch, Kerry, McIntosh, Laura, Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Thibodeau, Stephen N., McDonnell, Shannon K., Hebbring, Scott, Schaid, Daniel J., Lange, Ethan M., Cooney, Kathleen A., Tammela, Teuvo L.J., Schleutker, Johanna, Paiss, Thomas, Maier, Christiane, Grönberg, Henrik, Wiklund, Fredrik, Emanuelsson, Monica, and Isaacs, William B.

Published
2007

49. Characteristics of prostate cancer in families potentially linked to the hereditary prostate cancer 1 (HPC1) locus

Author

Gronberg, Henrik, Isaacs, Sarah D., Smith, Jeffrey R., Carpten, John D., Bova, G. Steven, Freije, Diha, Xu, Jianfeng, Meyers, Deborah A., Collin, Francis S., Trent, Jeffrey M., Walsh, Patrick C., and Isaacs, William B

Subjects
Prostate cancer -- Genetic aspects, Gene mutations -- Health aspects, Phenotype -- Analysis
Abstract

Men with a family history of prostate cancer should be screened for a mutation of the hereditary prostate cancer 1 (HPC1) gene so they can receive treatment during the early stages of the cancer. Researchers used genetic analysis to identify which of 74 families with hereditary prostate cancer might have an HPC1 mutation and whether their cancer had different characteristics than those who did not have the mutation. Overall, the cancers were similar except that men with the mutation got cancer at an earlier age and tended to have advanced disease., Context.--Approximately 9% of prostate cancer cases have been estimated to result from inheritance of mutated prostate cancer susceptibility genes. Few data exist as to whether there are clinical differences between prostate cancers that are inherited and those that occur in the general population. Objective.--To investigate phenotypic characteristics of families potentially linked to the hereditary prostate cancer 1 (HPC1) locus on chromosome 1q24-25. Design.--Retrospective case study in which clinical data were extracted from medical and pathological records. Families.--A total of 74 North American families with hereditary prostate cancer. Prostate cancer cases from the National Cancer Data Base were used as a reference population for comparison. Main Outcome Measures.--The families were divided into 2 groups: either potentially linked (33 families with 133 men with prostate cancer), and thus likely to be carrying an altered HPC1 gene, or potentially unlinked (41 families with 172 men with prostate cancer), on the basis of haplotype analysis in the region of HPC1. The age at diagnosis of prostate cancer, serum prostate-specific antigen levels, digital rectal examination status, stage, grade, primary treatment of prostate cancers, and occurrence of other cancers were compared between the groups. Results.--The mean age at diagnosis of prostate cancer for men in potentially linked families was significantly lower than for men in potentially unlinked families (63.7 vs 65.9 years, respectively, P=.01; mean age at diagnosis in the reference population was 71.6 years). Higher-grade cancers (grade 3) were more common in potentially linked families, and advanced-stage disease was found in 41% of the case patients in potentially linked families compared with 31% in both the potentially unlinked families and the reference groups (P=.03 for the latter comparison). In the other clinical parameters, we found no significant differences between the groups. A modest excess of breast cancer and colon cancer was found in potentially linked families in comparison with potentially unlinked families, but this difference was not statistically significant. Conclusions.--Families that provide evidence for segregation of an altered HPC1 gene are characterized by multiple cases of prostate cancer that, in most respects, are indistinguishable from nonhereditary cases. However, 3 characteristics were observed: younger age at diagnosis, higher-grade tumors, and more advanced-stage disease. Our study shows that a significant fraction of hereditary prostate cancers are diagnosed in advanced stages, emphasizing the clinical importance of early detection in men potentially carrying prostate cancer susceptibility genes. These findings support the current recommendations to screen men with a positive family history of prostate cancer beginning at age 40 years. JAMA. 1997;278:1251-1255

Published
1997

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