1. Treatment Outcomes of Presumed Rickettsial Retinitis: Evidence from OCTA Based Quantitative Analysis.
- Author
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Baharani A and Reddy P RR
- Subjects
- Humans, Retrospective Studies, Male, Female, Middle Aged, Adult, Treatment Outcome, Glucocorticoids therapeutic use, Retinal Vessels pathology, Retinal Vessels diagnostic imaging, Aged, Rickettsia Infections diagnosis, Rickettsia Infections drug therapy, Ischemia diagnosis, Ischemia drug therapy, Rickettsia, Tomography, Optical Coherence methods, Doxycycline therapeutic use, Retinitis diagnosis, Retinitis drug therapy, Retinitis microbiology, Fluorescein Angiography methods, Anti-Bacterial Agents therapeutic use, Eye Infections, Bacterial drug therapy, Eye Infections, Bacterial diagnosis, Eye Infections, Bacterial microbiology, Visual Acuity physiology
- Abstract
Aim: To quantify retinal ischemia following presumed rickettsial retinitis (RR). To compare outcomes between initial treatment with Doxycycline (Group 1) versus steroids (Group 2)., Methods: Retrospective analysis of patients with presumed RR was done. ImageJ software was used to obtain %area of ischemia on swept-source optical coherence tomography angiography (SS-OCTA)., Results: Eleven eyes of 8 patients belonged to Group1 and 6 eyes of 3 patients belonged to Group 2. The BCVA improved from logMAR 0.8 ∓ 0.7 to logMAR 0.06 ∓ 0.08 ( p < 0.002) and central foveal thickness (CFT) changed from 479μ ∓ 341.3μ to 163.5μ ∓ 20.5μ ( p < 0.005) after a median of 5 weeks in Group 1. In Group 2, BCVA improved from logMAR 1.03 ∓ 0.05 to logMAR 0.23 ∓ 0.23 ( p < 0.004) and CFT changed from 286.5μ ∓ 158.8μ to 177.5μ ∓ 25.9μ (>0.05) following a mean of 11 weeks. Mean %area of ischemia was 4.6 ∓ 1.5 in Group 1 and 13.9 ∓ 4.1 in Group 2., Conclusion: Analysis of flow deficit on SS-OCTA confirms that treatment with Doxycycline in presumed RR results in less ischemia and quicker recovery than initial treatment with steroids.
- Published
- 2024
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