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11. Imaging Traction Stresses

Author

Dembo, Micah, Oliver, Tim, Ishihara, Akira, Jacobson, Ken, Alt, Wolfgang, editor, Deutsch, Andreas, editor, and Dunn, Graham A., editor

Published
1997
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28. Regulation of cell movement is mediated by stretch-activated calcium channels

Author

Lee, Juliet, Ishihara, Akira, Oxford, Gerry, Johnson, Barry, and Jacobson, Ken

Subjects
Calcium -- Research, Cell migration -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Intracellular calcium controls many molecular process required for cell movement. It is not known how calcium controls overall cell movement. Transient increases in intracellular calcium during the locomotion of fish epithelial keratocytes were found to happen more frequently in cells that are temporarily stuck to the substratum or when mechanically stretched. Calcium transients occur from the activation of stretch-activated calcium channels.

Published
1999

34. Principles of locomotion for simple-shaped cells

Author

Lee, Juliet, Ishihara, Akira, Theriot, Julie A., and Jacobson, Ken

Subjects
Locomotion -- Research, Keratinocytes -- Research, Fishes -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A kinematic description of locomotion of fish epidermal keratocytes is presented. These cells exhibit semicircular shape and persistent 'gliding' motion. It is proposed that the extension on the front and retraction of the rear of these cells occurs orthogonal to the cell edge. In addition, a graded distribution of extension and retraction rates along the cell margin maintains cell shape and size during locomotion.

Published
1993

38. Aggressive osteoblastoma of the calcaneus

Author

Miyayama, Haruhiko, Sakamoto, Kiminori, Ide, Mari, Ise, Kouhei, Hirota, Kouzou, Yasunaga, Tadamasa, and Ishihara, Akira

Subjects
Bone diseases, Tumors -- Diagnosis, Bone tumors -- Diagnosis, Health
Abstract

Aggressive osteoblastoma of the left calcaneus in 29-year-old Japanese woman is reported. Her initial symptom was heel pain while walking. This was a primary calcaneal tumor, initially diagnosed as a benign osteoblastoma. After a 5-year follow-up (from the initial curettage), there was local recurrence. The histologic findings of aggressive osteoblastoma were confirmed after right lower leg amputation. The recurrent tumor was mildly aggressive to the talocalcanean joint and the retrocalcaneal area, without distant metastasis. The characteristics of the primary and recurrent tumors were examined by the radiologic, histologic, and electron microscopic procedures. Although there are questions about aggressive osteoblastoma, the authors believe that there are osteoblastic tumors of borderline malignancy between benign osteoblastoma and low-grade osteosarcoma. The current case was an example compatible with an aggressive osteoblastoma with the proposed name of Dorfman classification Group 4. Cancer 1993; 71:346-53.

Published
1993

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