1. Combined magnetic nanoparticle - microwave breast imaging
- Author
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Isleifson, Dustin (Electrical and Computer Engineering), Mojabi, Puyan (Electrical and Computer Engineering), Gilmore, Colin, LoVetri, Joe, Naruganahalli Channa, Vijayakumari, Isleifson, Dustin (Electrical and Computer Engineering), Mojabi, Puyan (Electrical and Computer Engineering), Gilmore, Colin, LoVetri, Joe, and Naruganahalli Channa, Vijayakumari
- Abstract
Background: Microwave Imaging (MWI) provides a method for imaging and quantitative reconstruction of permittivity and permeability using antennas and electromagnetic waves. MWI has been used for breast-cancer detection amongst many other applications. A possible way of enhancing MWI with a contrast agent is through the use of Magnetic Nanoparticles (MNPs). MNPs will change their permeability with the application of an external DC magnetic field, and thus placing an MWI chamber inside of an electromagnet allows us to generate differential scattered fields by turning the magnet ON and OFF. Objective: This thesis focuses on collecting the raw data from, and experimentally imaging MNP in an MWI system. Methods: Using a pre-existing MWI system based on quasi-resonant flat faceted imaging chamber, 24 monopole antennas were used to create a system capable of both detecting MNP and imaging the resulting data. The MWI system was placed in the bore of an electromagnet and experimental data using breast phantoms with MNP tumors (spheres filled with MNP and carrier fluid) was collected. The system at various frequencies was simulated using a Discontinuous Galerkin forward solver, and the collected data was calibrated with the forward solver output and inverted using the Contrast Source Inversion method, showing successful inversion of the expected permeability changes at the frequencies of interest. Results: Experimental signal from the magnetic contrast of the MNPs was observed at and around 2GHz when the MNP tumors were in the breast phantom (for various positions and concentrations of the MNP). Quantitative 3D imaging of the permeability was attempted for various frequencies where the MNP signal was strong. While some images showed the permeability expected from the MNP, most did not. First, we showed successful image reconstruction of permittivity at several other frequencies than achievable before. An analysis of our data and inversion processes showed that:(1) The raw MNP
- Published
- 2024