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9 results on '"Issa, Ahmed S."'

1. Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study

Author

Mohamed, Osama Nady, Ibrahim, Sharehan Abdelrahman, Elsaghir, Shereen Mohammed Mohammed, Mohamed, Marwa Ibrahim, Fathy, Basma, Dardeer, Ahmed M., Shehata, Sayed, Mohammed, Hassan M. H., Setouhi, Amr, Ahmed, Ayat Mostafa Mohamed, Kamel, Asmaa Khalf, Ismail, Doaa Elzaeem, Abbas, Nehal I., Ziady, Ahmed Fathy Kamel, Esmaeel, Tamer El Zaeem, Issa, Ahmed S., Yassin, Ahmed M., Hussein, Mostafa Mahmoud, Abdelghany, Mostafa M., Nagy, Momen Mostafa, Ayad, Michael Samuel, and Kamel, Shaimaa F.

Published
2024
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5. Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study

Author

Mohamed, Osama Nady, Ibrahim, Sharehan Abdelrahman, Elsaghir, Shereen Mohammed Mohammed, Mohamed, Marwa Ibrahim, Fathy, Basma, Dardeer, Ahmed M., Shehata, Sayed, Mohammed, Hassan M. H., Setouhi, Amr, Ahmed, Ayat Mostafa Mohamed, Kamel, Asmaa Khalf, Ismail, Doaa Elzaeem, Abbas, Nehal I., Ziady, Ahmed Fathy Kamel, Esmaeel, Tamer El Zaeem, Issa, Ahmed S., Yassin, Ahmed M., Hussein, Mostafa Mahmoud, Abdelghany, Mostafa M., Nagy, Momen Mostafa, Ayad, Michael Samuel, and Kamel, Shaimaa F.

Abstract

Background: Studies on renal vein thrombosis have been conducted as case reports or case series. The renal outcomes and mortality risk of renal vein thrombosis have not been fully established. We aimed to investigate the clinical characteristics, treatment modalities, and predictors of renal outcomes and mortality in patients with renal vein thrombosis in a large multicenter cohort. Methods: We retrospectively assessed 182 patients with renal vein thrombosis diagnosed between January 2011 and May 2023 using either Doppler ultrasonography or computed tomography venography. The main outcomes analyzed were all-cause mortality, and worsening kidney function. Results: We evaluated 182 patients comprising 76 males (41.8%) and 106 females (58.2%). Nephrotic syndrome was the most common cause (51.6%) followed by malignancy (33%) and post-trauma or surgery (11%). Kidney function worsened in 126 patients (69.2%). Acute kidney injury (AKI) was identified in 72 patients (39.6%), whereas 54 patients (29.7%) developed chronic kidney disease (CKD). Multivariate logistic regression showed that declining kidney function was reliably predicted by nephrotic syndrome (Odds ratio (OR): 6.41, P= 0.004), serum albumin (OR: 0.31, P= 0.003), and diabetes mellitus (OR: 14.04, P< 0.001). Eighty-two patients (45.1%) died while being monitored. Sepsis accounted for the majority of deaths (25.3%). Bilateral renal vein thrombosis (Hazard Ratio (HR): 5.61, P< 0.001), malignancy (HR: 6.15, P= 0.004), serum albumin (HR: 0.12, P< 0.001), hemoglobin (Hb) level (HR: 0.102, P< 0.001) and diabetes mellitus (HR: 2.42, P= 0.007) were all reliable predictors of all-cause mortality using multivariate Cox regression. Conclusion: Renal vein thrombosis is associated with a higher risk of mortality and worsening kidney function. It is essential to promptly identify high risk patients and start early treatment to prevent unfavorable outcomes. Graphical abstract:

Published
2025
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9. The Relationship of Fetuin-A with Coronary Calcification, Carotid Atherosclerosis, and Mortality Risk in Non-Dialysis Chronic Kidney Disease.

Author

Mohamed ON, Mohamed MRM, Hassan IG, Alakkad AF, Othman A, Setouhi A, and Issa AS

Abstract

Objective: This study investigated the relationship of fetuin-A with coronary calcification, carotid atherosclerosis, and mortality risk in non-dialysis chronic kidney disease (CKD)., Methods: The study included 135 adult patients with CKD at stages 3-5, who were divided into coronary artery calcification (CAC) and non-CAC groups. We excluded current smokers and individuals with diabetes mellitus, inflammatory conditions, liver diseases, acute kidney failure, chronic hemodialysis, and cancer. We conducted kidney function tests, complete blood counts, and measured serum levels of fetuin-A, tumor necrosis factor-alpha (TNF-α), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), total cholesterol (TC), total triglycerides (TG), high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Cardiac spiral computed tomography was used to calculate the CAC score, employing the Agatston method. Carotid ultrasonography was performed to assess carotid intima-media thickness (CIMT) and to detect the presence of plaques., Results: CAC patients had considerably higher levels of TNF-α ( p <0.001), IL-6 ( p <0.001), hs-CRP ( p =0.006), TC, TG, parathyroid hormone (PTH) ( p <0.001) and phosphorus ( p <0.001) than non-CAC patients. They also had significantly lower levels of fetuin-A ( p <0.001). Fetuin-A was considerably lower in CKD subgroups as CKD progressed. Fetuin-A ( p =0.046), age ( p =0.009), TNF-α ( p =0.027), IL-6 ( p =0.005), TG ( p =0.002), PTH ( p =0.002), and phosphorus ( p =0.004) were significant predictors of CAC. CAC and fetuin-A were strong predictors of all-cause mortality and cardiovascular (CV) mortality. Fetuin-A was a significant predictor of CIMT ( p =0.045)., Conclusion: Fetuin-A reliably predicted CAC and CIMT. Fetuin-A and CAC emerged as significant risk factors for all-cause and CV mortality in non-dialysis CKD., Competing Interests: Conflict of Interest: The authors have no conflicts of interest to declare., (© 2024 The Korean Society of Lipid and Atherosclerosis.)

Published
2024
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