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2. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

Author

Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, and Fukuhara, Takasuke

Published
2024
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4. The International Linear Collider: Report to Snowmass 2021

Author

Aryshev, Alexander, Behnke, Ties, Berggren, Mikael, Brau, James, Craig, Nathaniel, Freitas, Ayres, Gaede, Frank, Gessner, Spencer, Gori, Stefania, Grojean, Christophe, Heinemeyer, Sven, Jeans, Daniel, Kruger, Katja, List, Benno, List, Jenny, Liu, Zhen, Michizono, Shinichiro, Miller, David W., Moult, Ian, Murayama, Hitoshi, Nakada, Tatsuya, Nanni, Emilio, Nojiri, Mihoko, Padamsee, Hasan, Perelstein, Maxim, Peskin, Michael E., Poeschl, Roman, Posen, Sam, Robson, Aidan, Strube, Jan, Suehara, Taikan, Tian, Junping, Titov, Maxim, Vos, Marcel, White, Andrew, Wilson, Graham, Yokoya, Kaoru, Zarnecki, Aleksander Filip, Adachi, Ichiro, Agashe, Kaustubh, Jovin, Tatjana Agatonovic, Aihara, Hiroaki, Altmannshofer, Wolfgang, Alves, Daniele, Anguiano, Justin, Aoki, Ken-Ichi, Aoki, Masato, Aoki, Toshihiro, Aoki, Yumi, Arai, Yasuo, Araki, Hayato, Asada, Haruka, Asai, Kento, Asai, Shoji, Attie, David, Baer, Howard, Bagger, Jonathan, Bai, Yang, Bailey, Ian, Barrue, Ricardo, Bartoldus, Rainer, Barzi, Emanuela, Basso, Matthew, Bauerdick, Lothar, Baum, Sebastian, Bellerive, Alain, Belomestnykh, Sergey, Antequera, Jorge Berenguer, Beyer, Jakob, Bhat, Pushpalatha, Bilki, Burak, Black, Kevin, Bloom, Kenneth, Bodwin, Geoffrey, Boisvert, Veronique, Boran, Fatma, Boudry, Vincent, Boughezal, Radja, Boveia, Antonio, Bozovic-Jelisavcic, Ivanka, Brient, Jean-Claude, Brodsky, Stanley, Brunetti, Laurent, Buesser, Karsten, Bulyak, Eugene, Burrows, Philip N., Burt, Graeme C., Cai, Yunhai, Cairo, Valentina, Canepa, Anadi, Celiberto, Francesco Giovanni, Cenni, Enrico, Chacko, Zackaria, Chaikovska, Iryna, Checchin, Mattia, Chen, Lisong, Chen, Thomas Y., Cheng, Hsin Chia, Cho, Gi-Chol, Choudhary, Brajesh, Clarke, Jim, Cline, James, Co, Raymond, Cohen, Timothy, Colas, Paul, Damerell, Chris, Das, Arindam, Dasu, Sridhara, Dawson, Sally, de Blas, Jorge, de Lima, Carlos Henrique, Deandrea, Aldo, Dehmelt, Klaus, Delayen, Jean, Demarteau, Marcel, Denisov, Dmitri, Dermisek, Radovan, Dieguez, Angel, Dohmae, Takeshi, Dopke, Jens, Dort, Katharina, Du, Yong, Dudar, Bohdan, Dutta, Bhaskar, Dutta, Juhi, Einhaus, Ulrich, Elsen, Eckhard, Endo, Motoi, Eremeev, Grigory, Eren, Engin, Erler, Jens, Esarey, Eric, Everett, Lisa, Golfe, Angeles Faus, Garcia, Marcos Fernandez, Foster, Brian, Fourches, Nicolas, Fouz, Mary-Cruz, Fujii, Keisuke, Fujimoto, Junpei, Torregrosa, Esteban Fullan, Furukawa, Kazuro, Fusayasu, Takahiro, Fuster, Juan, Ganjour, Serguei, Gao, Yuanning, Gaur, Naveen, Geng, Rongli, Georgi, Howard, Gherghetta, Tony, Goldstein, Joel, Goncalves, Dorival, Gonski, Julia, Gonzalo, Tomas, Goto, Takeyoshi, Goto, Toru, Graf, Norman, Grames, Joseph, Grannis, Paul, Gray, Lindsey, Grohsjean, Alexander, Gu, Jiayin, Guler, Yalcin, Gutierrez, Phillip, Haba, Junji, Haber, Howard, Hallford, John, Hamaguchi, Koichi, Han, Tao, Hara, Kazuhiko, Harada, Daisuke, Hashimoto, Koji, Hashino, Katsuya, Hayashi, Masahito, Heinrich, Gudrun, Hidaka, Keisho, Higuchi, Takeo, Hinode, Fujio, Hioki, Zenro, Hirose, Minoru, Hiroshima, Nagisa, Hisano, Junji, Hollik, Wolfgang, Homiller, Samuel, Hong, Sungwoo, Hook, Anson, Horii, Yasuyuki, Hoshina, Hiroki, Hristova, Ivana, Huitu, Katri, Hyakutake, Yoshifumi, Iijima, Toru, Ikematsu, Katsumasa, Ilderton, Anton, Inami, Kenji, Irles, Adrian, Ishikawa, Akimasa, Ishiwata, Koji, Ito, Hayato, Ivanov, Igor, Iwamoto, Sho, Iwamoto, Toshiyuki, Iwasaki, Masako, Iwashita, Yoshihisa, Jia, Haoyi, Morales, Fabricio Jimenez, Joshi, Prakash, Jung, Sunghoon, Kacarevic, Goran, Kagan, Michael, Kakizaki, Mitsuru, Kalinowski, Jan, Kaminski, Jochen, Kanaya, Kazuyuki, Kanemura, Shinya, Kanno, Hayato, Kano, Yuya, Kashiwagi, Shigeru, Kato, Yukihiro, Kawada, Nanami, Kawada, Shin-ichi, Kawagoe, Kiyotomo, Khoze, Valery, Kichimi, Hiromichi, Kim, Doojin, Kitahara, Teppei, Kitano, Ryuichiro, Klamka, Jan, Komamiya, Sachio, Kong, K. C., Konomi, Taro, Kotera, Katsushige, Kou, Emi, Kravchenko, Ilya, Kubo, Kiyoshi, Kubo, Takayuki, Kumaoka, Takuya, Kumar, Ashish, Kumar, Nilanjana, Kunath, Jonas, Kundu, Saumyen, Kunitomo, Hiroshi, Kurata, Masakazu, Kuriki, Masao, Kusenko, Alexander, Lagouri, Theodota, Lankford, Andrew J., Lastovicka-Medin, Gordana, Diberder, Francois Le, Lee, Claire, Liepe, Matthias, Linacre, Jacob, Liptak, Zachary, Lomte, Shivani, Low, Ian, Ma, Yang, Maalouf, Hani, MacFarlane, David, Madison, Brendon, Madlener, Thomas, Maeda, Tomohito, Malek, Paul, Mandal, Sanjoy, Markiewicz, Thomas, Marshall, John, Martens, Aurelien, Martin, Victoria, Martinello, Martina, Rivero, Celso Martinez, Maru, Nobuhito, Matheson, John, Matsumoto, Shigeki, Matsunaga, Hiroyuki, Matsuo, Yutaka, Mawatari, Kentarou, Mbagwu, Johnpaul, McIntosh, Peter, McKeown, Peter, Meade, Patrick, Mekala, Krzysztof, Merkel, Petra, Mihara, Satoshi, Miralles, Víctor, Lopez, Marcos Miralles, Mishima, Go, Mishima, Satoshi, Mistlberger, Bernhard, Mitov, Alexander, Miyabayashi, Kenkichi, Miyamoto, Akiya, Mohanty, Gagan, Monaco, Laura, Mondragon, Myriam, Montgomery, Hugh E., Moortgat-Pick, Gudrid, Morange, Nicolas, Llacer, María Moreno, Moretti, Stefano, Mori, Toshinori, Morii, Toshiyuki, Moroi, Takeo, Morrissey, David, Nachman, Benjamin, Nagano, Kunihiro, Nakajima, Jurina, Nakamura, Eiji, Narita, Shinya, Nath, Pran, Nelson, Timothy, Newbold, David, Niki, Atsuya, Nishimura, Yasuhiro, Nishiyama, Eisaku, Nomura, Yasunori, Nowak, Kacper, Nozaki, Mitsuaki, de Vera, María Teresa Nunez Pardo, Ochoa, Ines, Ogata, Masahito, Ohashi, Satoru, Ohta, Hikaru, Ohta, Shigemi, Ohuchi, Norihito, Oide, Hideyuki, Okada, Nobuchika, Okada, Yasuhiro, Okawa, Shohei, Okayasu, Yuichi, Okugawa, Yuichi, Okugi, Toshiyuki, Okui, Takemichi, Okuyama, Yoshitaka, Omet, Mathieu, Omori, Tsunehiko, Ono, Hiroaki, Onoe, Tomoki, Ootani, Wataru, Otono, Hidetoshi, Ozawa, Shuhei, Griso, Simone Pagan, Papa, Alessandro, Paparella, Rocco, Park, Eun-Kyung, Perez, Gilad, Perez-Lorenzana, Abdel, Peters, Yvonne, Petriello, Frank, Piedra, Jonatan, Porod, Werner, Potter, Christopher, Price, Alan, Radkhorrami, Yasser, Reina, Laura, Reuter, Juergen, Richard, Francois, Riemann, Sabine, Rimmer, Robert, Rizzo, Thomas, Robens, Tania, Ruber, Roger, Jimeno, Alberto Ruiz, Saeki, Takayuki, Saha, Ipsita, Saito, Tomoyuki, Sakaguchi, Makoto, Sakai, Tadakatsu, Sakaki, Yasuhito, Sakurai, Kodai, Salvatico, Riccardo, Salvatore, Fabrizio, San, Yik Chuen, Sandick, Pearl, Sanuki, Tomoyuki, Sasikumar, Kollassery Swathi, Schaefer, Oliver, Schaefer, Ruth, Schneekloth, Uwe, Schoerner-Sadenius, Thomas, Schroeder, Carl, Schuster, Philip, Schwartzman, Ariel, Schwienhorst, Reinhard, Sefkow, Felix, Seiya, Yoshihiro, Sekiguchi, Motoo, Sekizawa, Kazuyuki, Senyo, Katsumi, Sert, Hale, Sertore, Danielev, Settles, Ronald, Shafi, Qaisar, Shahdara, Tetsuo, Haghi, Barmak Shams Es, Sharma, Ashish, Shelton, Jessie, Shepherd-Themistocleous, Claire, Shibuya, Hiroto, Shidara, Tetsuo, Shimomura, Takashi, Shindou, Tetsuo, Shoji, Yutaro, Shu, Jing, Sievers, Ian, Simon, Frank, Singh, Rajeev, Soreq, Yotam, Stanitzki, Marcel, Stapnes, Steinar, Steinhebel, Amanda, Stupak, John, Su, Shufang, Suekane, Fumihiko, Sugamoto, Akio, Sugawara, Yuji, Sugimoto, Satoru, Sugimoto, Yasuhiro, Sugiyama, Hiroaki, Sumino, Yukinari, Sundrum, Raman, Suzuki, Atsuto, Suzuki, Shin, Swiatlowski, Maximilian, Tait, Tim M. P., Takahashi, Shota, Takahashi, Tohru, Takeshita, Tohru, Takeuchi, Michihisa, Takubo, Yosuke, Tanabe, Tomohiko, Tanedo, Philip, Tanimoto, Morimitsu, Tao, Shuichiro, Tata, Xerxes, Tauchi, Toshiaki, Taylor, Geoffrey, Terada, Takahiro, Terunuma, Nobuhiro, Thaler, Jesse, Thea, Alessandro, Tillinger, Finn, Timmermans, Jan, Tobioka, Kohsaku, Toda, Kouichi, Tokiyasu, Atsushi, Toma, Takashi, Torndal, Julie, Tosun, Mehmet, Tsai, Yu-Dai, Tseng, Shih-Yen, Tsumura, Koji, Tuckler, Douglas, Uchida, Yoshiki, Uchiyama, Yusuke, Ueda, Daiki, Ukegawa, Fumihiko, Umemori, Kensei, Urakawa, Junji, Vallee, Claude, Vega, Roberto, Velasco, Liliana, Verdu-Andres, Silvia, Vernieri, Caterina, Vila, Anna, Alvarez, Ivan Vila, Vossebeld, Joost, Vsrms, Raghava, Vukasinovic, Natasa, Wackeroth, Doreen, Wakida, Moe, Wang, Liantao, Washio, Masakazu, Watanabe, Takashi, Watson, Nigel, Watts, Gordon, Weiglein, Georg, Wells, James D., Wenskat, Marc, Westhoff, Susanne, White, Glen, Williams, Ciaran, Willocq, Stephane, Wing, Matthew, Winter, Alasdair, Winter, Marc, Wu, Yongcheng, Xie, Keping, Xu, Tao, Yakovlev, Vyacheslav, Yamada, Shuei, Yamamoto, Akira, Yamamoto, Hitoshi, Yamamoto, Kei, Yamamoto, Yasuchika, Yamanaka, Masato, Yamashita, Satoru, Yamatani, Masahiro, Yamatsu, Naoki, Yasui, Shigehiro, Yoda, Takuya, Yonamine, Ryo, Yoshihara, Keisuke, Yoshioka, Masakazu, Yoshioka, Tamaki, Yuasa, Fukuko, Yumino, Keita, Zerwas, Dirk, Zheng, Ya-Juan, Zhou, Jia, Zhu, Hua Xing, Zobov, Mikhail, and Zomer, Fabian

Subjects
Physics - Accelerator Physics, High Energy Physics - Experiment, High Energy Physics - Phenomenology
Abstract

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community., Comment: 356 pages, Large pdf file (40 MB) submitted to Snowmass 2021; v2 references to Snowmass contributions added, additional authors; v3 references added, some updates, additional authors

Published
2022

5. Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case

Author

Ito, Jumpei, Misawa, Naoko, Plianchaisuk, Arnon, Guo, Ziyi, Hina, Alfredo, Jr., Uriu, Keiya, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Yoshimura, Ryo, Kawakubo, Shusuke, Nishimura, Luca, Kosugi, Yusuke, Fujita, Shigeru, Chen, Luo, Tolentino, Jarel Elgin M., Pan, Lin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Strange, Adam P., Chiba, Mika, Iida, Keiko, Ohsumi, Naomi, Okumura, Kaho, Tanaka, Shiho, Ogawa, Eiko, Yasuda, Kyoko, Fukuda, Tsuki, Osujo, Rina, Fukuhara, Takasuke, Tamura, Tomokazu, Suzuki, Rigel, Suzuki, Saori, Ito, Hayato, Matsuno, Keita, Sawa, Hirofumi, Nao, Naganori, Tanaka, Shinya, Tsuda, Masumi, Wang, Lei, Oda, Yoshikata, Ferdous, Zannatul, Shishido, Kenji, Mizuma, Keita, Kojima, Isshu, Li, Jingshu, Tsubo, Tomoya, Tsujino, Shuhei, Nakagawa, So, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Takayama, Kazuo, Hashimoto, Rina, Deguchi, Sayaka, Watanabe, Yukio, Sakamoto, Ayaka, Yasuhara, Naoko, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Nakata, Yoshitaka, Futatsusako, Hiroki, Irie, Takashi, Kawabata, Ryoko, Tabata, Kaori, Nasser, Hesham, Shimizu, Ryo, Begum, MST Monira, Jonathan, Michael, Mugita, Yuka, Takahashi, Otowa, Ichihara, Kimiko, Motozono, Chihiro, Leong, Sharee, Saito, Akatsuki, Shofa, Maya, Shibatani, Yuki, Nishiuchi, Tomoko, Asakura, Hiroyuki, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Kuwata, Takeo, Kaku, Yu, Biswas, Shashwata, Matsumoto, Kaho, Shimizu, Mikiko, Kawanami, Yoko, Uraki, Ryuta, Okazaki, Kyo, Minami, Rumi, Nagasaki, Yoji, Nagashima, Mami, Yoshida, Isao, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ito, Mutsumi, Kiso, Maki, Yamayoshi, Seiya, Imai, Masaki, Ikeda, Terumasa, Sato, Kei, Toyoda, Mako, Ueno, Takamasa, Inoue, Takako, Tanaka, Yasuhito, Kimura, Kanako Tarakado, Hashiguchi, Takao, Sugita, Yukihiko, Noda, Takeshi, Morioka, Hiroshi, Kawaoka, Yoshihiro, and Matsushita, Shuzo

Published
2024
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6. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

Author

Sawa, Hirofumi, Mizuma, Keita, Li, Jingshu, Mimura, Yume, Ohari, Yuma, Tsubo, Tomoya, Ferdous, Zannatul, Shishido, Kenji, Mohri, Hiromi, Iida, Miki, Tsujino, Shuhei, Misawa, Naoko, Usui, Kaoru, Saikruang, Wilaiporn, Lytras, Spyridon, Kawakubo, Shusuke, Nishumura, Luca, Mendoza Tolentino, Jarel Elgin, Li, Wenye, Yo, Maximilian Stanley, Horinaka, Kio, Suganami, Mai, Chiba, Mika, Yoshimura, Ryo, Yasuda, Kyoko, Iida, Keiko, Strange, Adam Patrick, Ohsumi, Naomi, Tanaka, Shiho, Ogawa, Eiko, Okumura, Kaho, Fukuda, Tsuki, Osujo, Rina, Yoshida, Isao, Nakagawa, So, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Nagata, Kayoko, Nomura, Ryosuke, Horisawa, Yoshihito, Tashiro, Yusuke, Kawai, Yugo, Nakata, Yoshitaka, Futatsusako, Hiroki, Sakamoto, Ayaka, Yasuhara, Naoko, Hashiguchi, Takao, Suzuki, Tateki, Kimura, Kanako, Sasaki, Jiei, Nakajima, Yukari, Yajima, Hisano, Irie, Takashi, Kawabata, Ryoko, Sasaki-Tabata, Kaori, Shimizu, Ryo, Monira Begum, M.S.T., Jonathan, Michael, Mugita, Yuka, Leong, Sharee, Takahashi, Otowa, Ichihara, Kimiko, Ueno, Takamasa, Motozono, Chihiro, Toyoda, Mako, Saito, Akatsuki, Kosaka, Anon, Kawano, Miki, Matsubara, Natsumi, Nishiuchi, Tomoko, Zahradnik, Jiri, Andrikopoulos, Prokopios, Padilla-Blanco, Miguel, Konar, Aditi, Fujita, Shigeru, Plianchaisuk, Arnon, Deguchi, Sayaka, Ito, Hayato, Nao, Naganori, Wang, Lei, Nasser, Hesham, Tamura, Tomokazu, Kimura, Izumi, Kashima, Yukie, Suzuki, Rigel, Suzuki, Saori, Kida, Izumi, Tsuda, Masumi, Oda, Yoshitaka, Hashimoto, Rina, Watanabe, Yukio, Uriu, Keiya, Yamasoba, Daichi, Guo, Ziyi, Hinay, Alfredo A., Jr., Kosugi, Yusuke, Chen, Luo, Pan, Lin, Kaku, Yu, Chu, Hin, Donati, Flora, Temmam, Sarah, Eloit, Marc, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Suzuki, Yutaka, Ito, Jumpei, Ikeda, Terumasa, Tanaka, Shinya, Matsuno, Keita, Fukuhara, Takasuke, Takayama, Kazuo, and Sato, Kei

Published
2024
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9. Evaluation of the superconducting characteristics of multi-layer thin-film structures of NbN and SiO$_2$ on pure Nb substrate

Author

Katayama, R., Hayano, H., Kubo, T., Saeki, T., Ito, Hayato, Iwashita, Y., Tongu, H., Antoine, C. Z., Ito, R., and Nagata, T.

Subjects
Physics - Accelerator Physics
Abstract

In recent years, it has been pointed out that the maximum accelerating gradient of a superconducting RF cavity can be increased by coating the inner surface of the cavity with a multilayer thin-film structure consisting of alternating insulating and superconducting layers. In this structure, the principal parameter that limits the performance of the cavity is the critical magnetic field or effective $H_{C1}$ at which vortices begin penetrating into the superconductor layer. This is predicted to depend on the combination of the film thickness. We made samples that have a NbN/SiO$_2$ thin-film structure on a pure Nb substrate with several layers of NbN film deposited using DC magnetron sputtering method. Here, we report the measurement results of effective $H_{C1}$ of NbN/SiO$_2$(30 nm)/Nb multilayer samples with thicknesses of NbN layers in the range from 50 nm to 800 nm by using the third-harmonic voltage method. Experimental results show that an optimum thickness exists, which increases the effective $H_{C1}$ by 23.8 %., Comment: Contribution to the 19th International Conference on RF Superconductivity (SRF2019)

Published
2019

10. Lower Critical Field Measurement System based on Third-Harmonic Method for Superconducting RF Materials

Author

Ito, Hayato, Hayano, Hitoshi, Kubo, Takayuki, and Saeki, Takayuki

Subjects
Physics - Accelerator Physics, Condensed Matter - Superconductivity
Abstract

We develop a lower critical field (Hc1) measurement system using the third-harmonic response of an applied AC magnetic field from a solenoid coil positioned above a superconducting sample. Parameter Hc1 is measured via detection of the third-harmonic component, which drastically changes when a vortex begins to penetrate the superconductor with temperature increase. The magnetic field locally applied to one side of the sample mimics the magnetic field within superconducting radio-frequency (SRF) cavities and prevents edge effects of the superconducting sample. With this approach, our measurement system can potentially characterize surface-engineered SRF materials such as Superconductor-Insulator-Superconductor multilayer structure (S-I-S structure). As a validation test, we measure the temperature dependence of Hc1 of two high-RRR bulk Nb samples and obtain results consistent with the literature. We also confirm that our system can apply magnetic fields of at least 120 mT at 4-5 K without any problem of heat generation of the coil. This field value is higher than those reported in previous works and makes it possible to more accurately estimate Hc1 at lower temperatures., Comment: 17 pages, 11 figures

Published
2019
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12. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

Author

Tamura, Tomokazu, Yamasoba, Daichi, Oda, Yoshitaka, Ito, Jumpei, Kamasaki, Tomoko, Nao, Naganori, Hashimoto, Rina, Fujioka, Yoichiro, Suzuki, Rigel, Wang, Lei, Ito, Hayato, Kashima, Yukie, Kimura, Izumi, Kishimoto, Mai, Tsuda, Masumi, Sawa, Hirofumi, Yoshimatsu, Kumiko, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kanamune, Jun, Suzuki, Yutaka, Ohba, Yusuke, Yokota, Isao, Matsuno, Keita, Takayama, Kazuo, Tanaka, Shinya, Sato, Kei, and Fukuhara, Takasuke

Published
2023
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13. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Author

Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, and Sato, Kei

Published
2023
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14. Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

Author

Saito, Akatsuki, Tamura, Tomokazu, Zahradnik, Jiri, Deguchi, Sayaka, Tabata, Koshiro, Anraku, Yuki, Kimura, Izumi, Ito, Jumpei, Yamasoba, Daichi, Nasser, Hesham, Toyoda, Mako, Nagata, Kayoko, Uriu, Keiya, Kosugi, Yusuke, Fujita, Shigeru, Shofa, Maya, Monira Begum, MST, Shimizu, Ryo, Oda, Yoshitaka, Suzuki, Rigel, Ito, Hayato, Nao, Naganori, Wang, Lei, Tsuda, Masumi, Yoshimatsu, Kumiko, Kuramochi, Jin, Kita, Shunsuke, Sasaki-Tabata, Kaori, Fukuhara, Hideo, Maenaka, Katsumi, Yamamoto, Yuki, Nagamoto, Tetsuharu, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Ueno, Takamasa, Schreiber, Gideon, Takaori-Kondo, Akifumi, Shirakawa, Kotaro, Sawa, Hirofumi, Irie, Takashi, Hashiguchi, Takao, Takayama, Kazuo, Matsuno, Keita, Tanaka, Shinya, Ikeda, Terumasa, Fukuhara, Takasuke, and Sato, Kei

Published
2022
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15. Searching for Metastable Particles with Sub-Millimeter Displaced Vertices at Hadron Colliders

Author

Ito, Hayato, Jinnouchi, Osamu, Moroi, Takeo, Nagata, Natsumi, and Otono, Hidetoshi

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

A variety of new-physics models predict metastable particles whose decay length is $\lesssim 1$ mm. Conventional displaced-vertex searches are less sensitive to this sub-millimeter decay range, and thus such metastable particles have been looked for only in usual prompt decay searches. In this paper, we show that an additional event-selection cut based on the vertex reconstruction using charged tracks considerably improves the sensitivity of ordinary searches which rely only on kinematic selection criteria, for particles with a decay length of $\gtrsim 100$ $\mu \text{m}$. To that end, we consider a metastable gluino as an example, and study the impact of this new event-selection cut on gluino searches at the LHC by simulating both the signal and Standard Model background processes. Uncertainty of the displaced-vertex reconstruction due to the limited resolution of track reconstruction is taken into account. We also discuss possibilities for optimization of the kinematic selection criteria, which takes advantage of significant reduction of background through the requirement of displaced vertices. In addition, we demonstrate that using the method discussed in this paper it is possible to measure the lifetime of metastable particles with an ${\cal O}(1)$ accuracy at the high-luminosity LHC. Implications for a future 100 TeV collider are also studied, where produced particles tend to be more boosted and thus it is easier to detect the longevity of metastable particles., Comment: 55 pages, 24 figures

Published
2018
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16. Expression and characterization of a thermostable monoacylglycerol lipase from thermophilic Geobacillus kaustophilus.

Author

Doukyu, Noriyuki, Ito, Hayato, and Sugimoto, Kugako

Subjects
*ENZYME stability, *ORGANIC solvents, *FOOD emulsifiers, *TRITON X-100, *CIRCULAR dichroism
Abstract

Thermophilic Geobacillus kaustophilus HTA426 genome possesses a monoacylglycerol lipase (MAGL) gene. MAGLs can synthesize emulsifiers for use in the food and pharmaceutical industries from fatty acids and glycerol. They can also be used to analyze monoacylglycerol (MAG) levels in serum and food. The MAGL gene from strain HTA426 was artificially synthesized and heterologously expressed in Escherichia coli BL21(DE3). The recombinant His-tag fused MAGL (GkMAGL) was purified using a Ni2+-affinity column. The purified enzyme showed a temperature optimum at 65 °C and was stable up to 75 °C after 30 min incubation. In addition, the enzyme exhibited a pH optimum of 7.5 and was stable from pH 5.0 to 11.0. The enzyme hydrolyzed monoacylglycerols and showed the highest activity toward 1-monolauroylglycerol. The enzyme was stable in the presence of various organic solvents and detergents. The addition of Triton X-100 significantly increased GkMAGL activity. The thermal stability of the enzyme was higher than that of thermostable MAGL from Geobacillus sp. 12AMOR1 (12AMOR1_MAGL). Circular dichroism spectral analysis showed that the conformational stability of the GkMAGL was higher than that of 12AMOR1_MAGL at higher temperatures. These results indicate that the GkMAGL has useful features that can be used for various biotechnological applications. [ABSTRACT FROM AUTHOR]

Published
2025
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17. Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike

Author

Yamasoba, Daichi, Kimura, Izumi, Nasser, Hesham, Morioka, Yuhei, Nao, Naganori, Ito, Jumpei, Uriu, Keiya, Tsuda, Masumi, Zahradnik, Jiri, Shirakawa, Kotaro, Suzuki, Rigel, Kishimoto, Mai, Kosugi, Yusuke, Kobiyama, Kouji, Hara, Teppei, Toyoda, Mako, Tanaka, Yuri L., Butlertanaka, Erika P., Shimizu, Ryo, Ito, Hayato, Wang, Lei, Oda, Yoshitaka, Orba, Yasuko, Sasaki, Michihito, Nagata, Kayoko, Yoshimatsu, Kumiko, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Kuramochi, Jin, Seki, Motoaki, Fujiki, Ryoji, Kaneda, Atsushi, Shimada, Tadanaga, Nakada, Taka-aki, Sakao, Seiichiro, Suzuki, Takuji, Ueno, Takamasa, Takaori-Kondo, Akifumi, Ishii, Ken J., Schreiber, Gideon, Sawa, Hirofumi, Saito, Akatsuki, Irie, Takashi, Tanaka, Shinya, Matsuno, Keita, Fukuhara, Takasuke, Ikeda, Terumasa, and Sato, Kei

Published
2022
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18. Extending the LHC Reach for New Physics with Sub-Millimeter Displaced Vertices

Author

Ito, Hayato, Jinnouchi, Osamu, Moroi, Takeo, Nagata, Natsumi, and Otono, Hidetoshi

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Particles with a sub-millimeter decay length appear in many models of physics beyond the Standard Model. However, their longevity has been often ignored in their LHC searches and they have been regarded as promptly-decaying particles. In this letter, we show that, by requiring displaced vertices on top of the event selection criteria used in the ordinary search strategies for promptly-decaying particles, we can considerably extend the LHC reach for particles with a decay length of $\gtrsim 100~\mu{\rm m}$. We discuss a way of reconstructing sub-millimeter displaced vertices by exploiting the same technique used for the primary vertex reconstruction on the assumption that the metastable particles are always pair-produced and their decay products contain high-$p_{\rm T}$ jets. We show that, by applying a cut based on displaced vertices on top of standard kinematical cuts for the search of new particles, the LHC reach can be significantly extended if the decay length is $\gtrsim 100~\mu{\rm m}$. In addition, we may measure the lifetime of the target particle through the reconstruction of displaced vertices, which plays an important role in understanding the new physics behind the metastable particles., Comment: 18 pages, 6 figures

Published
2017
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19. Production and Decay of Di-photon Resonance at Future $e^+e^-$ Colliders

Author

Ito, Hayato and Moroi, Takeo

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Motivated by the ATLAS and CMS announcements of the excesses of di-photon events, we discuss the production and decay processes of di-photon resonance at future $e^+e^-$ colliders. We assume that the excess of the di-photon events at the LHC is explained by a scalar resonance decaying into a pair of photons. In such a case, the scalar interacts with standard model gauge bosons and, consequently, the production of such a scalar is possible at the $e^+e^-$ colliders. We study the production of the scalar resonance via the associated production with photon or $Z$, as well as via the vector-boson fusion, and calculate the cross sections of these processes. We also study the backgrounds, and discuss the detectability of the signals of scalar production with various decay processes of the scalar resonance. We also consider the case where the scalar resonance has an invisible decay mode, and study how the invisible decay can be observed at the $e^+e^-$ colliders., Comment: 21 pages, 10 figures

Published
2016
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20. Di-Higgs Decay of Stoponium at Future Photon-Photon Collider

Author

Ito, Hayato, Moroi, Takeo, and Takaesu, Yoshitaro

Subjects
High Energy Physics - Phenomenology
Abstract

We study the detectability of the stoponium in the di-Higgs decay mode at the photon-photon collider option of the International $e^+e^-$ Linear Collider (ILC), whose center-of-mass energy is planned to reach $\sim 1$ TeV. We find that $5\sigma$ detection of the di-Higgs decay mode is possible with the integrated electron-beam luminosity of $1 {\rm ab}^{-1}$ if the signal cross section, $\sigma(\gamma \gamma \rightarrow \sigma_{\tilde{t}_1} \rightarrow hh)$, of ${\cal O}(0.1)$ fb is realized for the stoponium mass smaller than $\sim$ 800 GeV at 1 TeV ILC. Such a value of the cross section can be realized in the minimal supersymmetric standard model (MSSM) with relatively large trilinear stop-stop-Higgs coupling constant. Implication of the stoponium cross section measurement for the MSSM stop sector is also discussed., Comment: 20 pages, 5 figures

Published
2016
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21. Studying 750 GeV Di-photon Resonance at Photon-Photon Collider

Author

Ito, Hayato, Moroi, Takeo, and Takaesu, Yoshitaro

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment
Abstract

Motivated by the recent LHC discovery of the di-photon excess at the invariant mass of ~ 750 GeV, we study the prospect of investigating the scalar resonance at a future photon-photon collider. We show that, if the di-photon excess observed at the LHC is due to a new scalar boson coupled to the standard-model gauge bosons, such a scalar boson can be observed and studied at the photon-photon collider with the center-of-mass energy of ~ 1 TeV in large fraction of parameter space., Comment: 16 pages, 3 figures. v2:Fig.1 corrected, discussions and references added. v3: version published in PLB

Published
2016
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22. Construction of a Historical Information Visualization System by Superposition of Old Map

Author

Ishida, Tomoyuki, Ito, Hayato, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Xhafa, Fatos, editor, and Hussain, Omar K., editor

Published
2020
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25. Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

Author

Fujita, Shigeru, primary, Plianchaisuk, Arnon, additional, Deguchi, Sayaka, additional, Ito, Hayato, additional, Nao, Naganori, additional, Wang, Lei, additional, Nasser, Hesham, additional, Tamura, Tomokazu, additional, Kimura, Izumi, additional, Kashima, Yukie, additional, Suzuki, Rigel, additional, Suzuki, Saori, additional, Kida, Izumi, additional, Tsuda, Masumi, additional, Oda, Yoshitaka, additional, Hashimoto, Rina, additional, Watanabe, Yukio, additional, Uriu, Keiya, additional, Yamasoba, Daichi, additional, Guo, Ziyi, additional, Hinay, Alfredo A., additional, Kosugi, Yusuke, additional, Chen, Luo, additional, Pan, Lin, additional, Kaku, Yu, additional, Chu, Hin, additional, Donati, Flora, additional, Temmam, Sarah, additional, Eloit, Marc, additional, Yamamoto, Yuki, additional, Nagamoto, Tetsuharu, additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Suzuki, Yutaka, additional, Sawa, Hirofumi, additional, Mizuma, Keita, additional, Li, Jingshu, additional, Mimura, Yume, additional, Ohari, Yuma, additional, Tsubo, Tomoya, additional, Ferdous, Zannatul, additional, Shishido, Kenji, additional, Mohri, Hiromi, additional, Iida, Miki, additional, Tsujino, Shuhei, additional, Misawa, Naoko, additional, Usui, Kaoru, additional, Saikruang, Wilaiporn, additional, Lytras, Spyridon, additional, Kawakubo, Shusuke, additional, Nishumura, Luca, additional, Mendoza Tolentino, Jarel Elgin, additional, Li, Wenye, additional, Yo, Maximilian Stanley, additional, Horinaka, Kio, additional, Suganami, Mai, additional, Chiba, Mika, additional, Yoshimura, Ryo, additional, Yasuda, Kyoko, additional, Iida, Keiko, additional, Strange, Adam Patrick, additional, Ohsumi, Naomi, additional, Tanaka, Shiho, additional, Ogawa, Eiko, additional, Okumura, Kaho, additional, Fukuda, Tsuki, additional, Osujo, Rina, additional, Yoshida, Isao, additional, Nakagawa, So, additional, Takaori-Kondo, Akifumi, additional, Shirakawa, Kotaro, additional, Nagata, Kayoko, additional, Nomura, Ryosuke, additional, Horisawa, Yoshihito, additional, Tashiro, Yusuke, additional, Kawai, Yugo, additional, Nakata, Yoshitaka, additional, Futatsusako, Hiroki, additional, Sakamoto, Ayaka, additional, Yasuhara, Naoko, additional, Hashiguchi, Takao, additional, Suzuki, Tateki, additional, Kimura, Kanako, additional, Sasaki, Jiei, additional, Nakajima, Yukari, additional, Yajima, Hisano, additional, Irie, Takashi, additional, Kawabata, Ryoko, additional, Sasaki-Tabata, Kaori, additional, Shimizu, Ryo, additional, Monira Begum, M.S.T., additional, Jonathan, Michael, additional, Mugita, Yuka, additional, Leong, Sharee, additional, Takahashi, Otowa, additional, Ichihara, Kimiko, additional, Ueno, Takamasa, additional, Motozono, Chihiro, additional, Toyoda, Mako, additional, Saito, Akatsuki, additional, Kosaka, Anon, additional, Kawano, Miki, additional, Matsubara, Natsumi, additional, Nishiuchi, Tomoko, additional, Zahradnik, Jiri, additional, Andrikopoulos, Prokopios, additional, Padilla-Blanco, Miguel, additional, Konar, Aditi, additional, Ito, Jumpei, additional, Ikeda, Terumasa, additional, Tanaka, Shinya, additional, Matsuno, Keita, additional, Fukuhara, Takasuke, additional, Takayama, Kazuo, additional, and Sato, Kei, additional

Published
2024
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27. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant

Author

50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, Fukuhara, Takasuke, 50632098, 10759509, Tamura, Tomokazu, Irie, Takashi, Deguchi, Sayaka, Yajima, Hisano, Tsuda, Masumi, Nasser, Hesham, Mizuma, Keita, Plianchaisuk, Arnon, Suzuki, Saori, Uriu, Keiya, Begum, Mst Monira, Shimizu, Ryo, Jonathan, Michael, Suzuki, Rigel, Kondo, Takashi, Ito, Hayato, Kamiyama, Akifumi, Yoshimatsu, Kumiko, Shofa, Maya, Hashimoto, Rina, Anraku, Yuki, Kimura, Kanako Terakado, Kita, Shunsuke, Sasaki, Jiei, Sasaki-Tabata, Kaori, Maenaka, Katsumi, Nao, Naganori, Wang, Lei, Oda, Yoshitaka, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda, Terumasa, Saito, Akatsuki, Matsuno, Keita, Ito, Jumpei, Tanaka, Shinya, Sato, Kei, Hashiguchi, Takao, Takayama, Kazuo, and Fukuhara, Takasuke

Abstract

Circulation of SARS-CoV-2 Omicron XBB has resulted in the emergence of XBB.1.5, a new Variant of Interest. Our phylogenetic analysis suggests that XBB.1.5 evolved from XBB.1 by acquiring the S486P spike (S) mutation, subsequent to the acquisition of a nonsense mutation in ORF8. Neutralization assays showed similar abilities of immune escape between XBB.1.5 and XBB.1. We determine the structural basis for the interaction between human ACE2 and the S protein of XBB.1.5, showing similar overall structures between the S proteins of XBB.1 and XBB.1.5. We provide the intrinsic pathogenicity of XBB.1 and XBB.1.5 in hamsters. Importantly, we find that the ORF8 nonsense mutation of XBB.1.5 resulted in impairment of MHC suppression. In vivo experiments using recombinant viruses reveal that the XBB.1.5 mutations are involved with reduced virulence of XBB.1.5. Together, our study identifies the two viral functions defined the difference between XBB.1 and XBB.1.5.

Published
2024

28. Proposal of a Regional Knowledge Inheritance System Using Location-Based AR and Historical Maps

Author

Ito, Hayato, Ohyanagi, Tatsuya, Ishida, Tomoyuki, Yonekura, Tatsuhiro, Kacprzyk, Janusz, Series Editor, Pal, Nikhil R., Advisory Editor, Bello Perez, Rafael, Advisory Editor, Corchado, Emilio S., Advisory Editor, Hagras, Hani, Advisory Editor, Kóczy, László T., Advisory Editor, Kreinovich, Vladik, Advisory Editor, Lin, Chin-Teng, Advisory Editor, Lu, Jie, Advisory Editor, Melin, Patricia, Advisory Editor, Nedjah, Nadia, Advisory Editor, Nguyen, Ngoc Thanh, Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Xhafa, Fatos, editor, Javaid, Nadeem, editor, and Enokido, Tomoya, editor

Published
2019
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30. Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection

Author

Tamura, Tomokazu, primary, Ito, Hayato, additional, Torii, Shiho, additional, Wang, Lei, additional, Tsujino, Shuhei, additional, Kamiyama, Akifumi, additional, Oda, Yoshitaka, additional, Morioka, Yuhei, additional, Suzuki, Saori, additional, Shirakawa, Kotaro, additional, Sato, Kei, additional, Yoshimatsu, Kumiko, additional, Matsuura, Yoshiharu, additional, Iwano, Satoshi, additional, Tanaka, Shinya, additional, and Fukuhara, Takasuke, additional

Published
2023
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31. Spinal subdural hematoma with sudden onset of paraplegia in a patient on oral anticoagulant therapy.

Author

Ito, Hayato, Hirata, Hirohito, Yoshihara, Tomohito, Tsukamoto, Masatsugu, Watanabe, Kazuyuki, Egashira, Yoshiaki, Mawatari, Masaaki, and Morimoto, Tadatsugu

Subjects
*SUBDURAL hematoma, *ORAL medication, *PEOPLE with paraplegia, *LEG pain, *LUMBAR pain, *PARAPLEGIA
Abstract

Key Clinical Message: Spinal subdural hematoma is uncommon but may become more prevalent with increasing anticoagulant use. Early diagnosis from symptoms like lower back pain and leg paralysis is crucial for timely intervention. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Author Response:: FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Author

Fujino, Yuzo, primary, Ueyama, Morio, additional, Ishiguro, Taro, additional, Ozawa, Daisaku, additional, Ito, Hayato, additional, Sugiki, Toshihiko, additional, Murata, Asako, additional, Ishiguro, Akira, additional, Gendron, Tania, additional, Mori, Kohji, additional, Tokuda, Eiichi, additional, Taminato, Tomoya, additional, Konno, Takuya, additional, Koyama, Akihide, additional, Kawabe, Yuya, additional, Takeuchi, Toshihide, additional, Furukawa, Yoshiaki, additional, Fujiwara, Toshimichi, additional, Ikeda, Manabu, additional, Mizuno, Toshiki, additional, Mochizuki, Hideki, additional, Mizusawa, Hidehiro, additional, Wada, Keiji, additional, Ishikawa, Kinya, additional, Onodera, Osamu, additional, Nakatani, Kazuhiko, additional, Petrucelli, Leonard, additional, Taguchi, Hideki, additional, and Nagai, Yoshitaka, additional

Published
2023
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35. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA in C9orf72-linked ALS/FTD

Author

Fujino, Yuzo, primary, Ueyama, Morio, additional, Ishiguro, Taro, additional, Ozawa, Daisaku, additional, Ito, Hayato, additional, Sugiki, Toshihiko, additional, Murata, Asako, additional, Ishiguro, Akira, additional, Gendron, Tania, additional, Mori, Kohji, additional, Tokuda, Eiichi, additional, Taminato, Tomoya, additional, Konno, Takuya, additional, Koyama, Akihide, additional, Kawabe, Yuya, additional, Takeuchi, Toshihide, additional, Furukawa, Yoshiaki, additional, Fujiwara, Toshimichi, additional, Ikeda, Manabu, additional, Mizuno, Toshiki, additional, Mochizuki, Hideki, additional, Mizusawa, Hidehiro, additional, Wada, Keiji, additional, Ishikawa, Kinya, additional, Onodera, Osamu, additional, Nakatani, Kazuhiko, additional, Petrucelli, Leonard, additional, Taguchi, Hideki, additional, and Nagai, Yoshitaka, additional

Published
2023
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37. Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5

Author

10759509, Tamura, Tomokazu, Yamasoba, Daichi, Oda, Yoshitaka, Ito, Jumpei, Kamasaki, Tomoko, Nao, Naganori, Hashimoto, Rina, Fujioka, Yoichiro, Suzuki, Rigel, Wang, Lei, Ito, Hayato, Kashima, Yukie, Kimura, Izumi, Kishimoto, Mai, Tsuda, Masumi, Sawa, Hirofumi, Yoshimatsu, Kumiko, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kanamune, Jun, Suzuki, Yutaka, Ohba, Yusuke, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Yokota, Isao, Matsuno, Keita, Takayama, Kazuo, Tanaka, Shinya, Sato, Kei, Fukuhara, Takasuke, 10759509, Tamura, Tomokazu, Yamasoba, Daichi, Oda, Yoshitaka, Ito, Jumpei, Kamasaki, Tomoko, Nao, Naganori, Hashimoto, Rina, Fujioka, Yoichiro, Suzuki, Rigel, Wang, Lei, Ito, Hayato, Kashima, Yukie, Kimura, Izumi, Kishimoto, Mai, Tsuda, Masumi, Sawa, Hirofumi, Yoshimatsu, Kumiko, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kanamune, Jun, Suzuki, Yutaka, Ohba, Yusuke, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Yokota, Isao, Matsuno, Keita, Takayama, Kazuo, Tanaka, Shinya, Sato, Kei, and Fukuhara, Takasuke

Abstract

The unremitting emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants necessitates ongoing control measures. Given its rapid spread, the new Omicron subvariant BA.5 requires urgent characterization. Here, we comprehensively analyzed BA.5 with the other Omicron variants BA.1, BA.2, and ancestral B.1.1. Although in vitro growth kinetics of BA.5 was comparable among the Omicron subvariants, BA.5 was much more fusogenic than BA.1 and BA.2. Airway-on-a-chip analysis showed that, among Omicron subvariants, BA.5 had enhanced ability to disrupt the respiratory epithelial and endothelial barriers. Furthermore, in our hamster model, in vivo pathogenicity of BA.5 was slightly higher than that of the other Omicron variants and less than that of ancestral B.1.1. Notably, BA.5 gains efficient virus spread compared with BA.1 and BA.2, leading to prompt immune responses. Our findings suggest that BA.5 has low pathogenicity compared with the ancestral strain but enhanced virus spread /inflammation compared with earlier Omicron subvariants.

Published
2023

38. Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

Author

80833334, 10759509, 50632098, Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, Sato, Kei, 80833334, 10759509, 50632098, Ito, Jumpei, Suzuki, Rigel, Uriu, Keiya, Itakura, Yukari, Zahradnik, Jiri, Kimura, Kanako Terakado, Deguchi, Sayaka, Wang, Lei, Lytras, Spyros, Tamura, Tomokazu, Kida, Izumi, Nasser, Hesham, Shofa, Maya, Begum, Mst Monira, Tsuda, Masumi, Oda, Yoshitaka, Suzuki, Tateki, Sasaki, Jiei, Sasaki-Tabata, Kaori, Fujita, Shigeru, Yoshimatsu, Kumiko, Ito, Hayato, Nao, Naganori, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Yamamoto, Yuki, Nagamoto, Tetsuharu, Kuramochi, Jin, Schreiber, Gideon, The Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito, Akatsuki, Matsuno, Keita, Takayama, Kazuo, Hashiguchi, Takao, Tanaka, Shinya, Fukuhara, Takasuke, Ikeda, Terumasa, and Sato, Kei

Abstract

In late 2022, various Omicron subvariants emerged and cocirculated worldwide. These variants convergently acquired amino acid substitutions at critical residues in the spike protein, including residues R346, K444, L452, N460, and F486. Here, we characterize the convergent evolution of Omicron subvariants and the properties of one recent lineage of concern, BQ.1.1. Our phylogenetic analysis suggests that these five substitutions are recurrently acquired, particularly in younger Omicron lineages. Epidemic dynamics modelling suggests that the five substitutions increase viral fitness, and a large proportion of the fitness variation within Omicron lineages can be explained by these substitutions. Compared to BA.5, BQ.1.1 evades breakthrough BA.2 and BA.5 infection sera more efficiently, as demonstrated by neutralization assays. The pathogenicity of BQ.1.1 in hamsters is lower than that of BA.5. Our multiscale investigations illuminate the evolutionary rules governing the convergent evolution for known Omicron lineages as of 2022.

Published
2023

39. Smoking enhances the expression of angiotensin-converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection

Author

Suzuki, Rigel, Ono, Yuki, Noshita, Koji, Kim, Kwang Su, Ito, Hayato, Morioka, Yuhei, Tamura, Tomokazu, Okuzaki, Daisuke, Tagawa, Tetsuzo, Takenaka, Tomoyoshi, Yoshizumi, Tomoharu, Shimamura, Teppei, Iwami, Shingo, Fukuhara, Takasuke, Suzuki, Rigel, Ono, Yuki, Noshita, Koji, Kim, Kwang Su, Ito, Hayato, Morioka, Yuhei, Tamura, Tomokazu, Okuzaki, Daisuke, Tagawa, Tetsuzo, Takenaka, Tomoyoshi, Yoshizumi, Tomoharu, Shimamura, Teppei, Iwami, Shingo, and Fukuhara, Takasuke

Abstract

Smoking is one of the risk factors most closely related to the severity of coronavirus disease 2019 (COVID-19). However, the relationship between smoking history and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is unknown. In this study, we evaluated the ACE2 expression level in the lungs of current smokers, ex-smokers, and nonsmokers. The ACE2 expression level of ex-smokers who smoked cigarettes until recently (cessation period shorter than 6 months) was higher than that of nonsmokers and ex-smokers with a long history of nonsmoking (cessation period longer than 6 months). We also showed that the efficiency of SARS-CoV-2 infection was enhanced in a manner dependent on the angiotensin-converting enzyme 2 (ACE2) expression level. Using RNA-seq analysis on the lungs of smokers, we identified that the expression of inflammatory signaling genes was correlated with ACE2 expression. Notably, with increasing duration of smoking cessation among ex-smokers, not only ACE2 expression level but also the expression levels of inflammatory signaling genes decreased. These results indicated that smoking enhances the expression levels of ACE2 and inflammatory signaling genes. Our data suggest that the efficiency of SARS-CoV-2 infection is enhanced by smoking-mediated upregulation of ACE2 expression level.

Published
2023

41. A third dose of the BNT162b2 mRNA vaccine sufficiently improves the neutralizing activity against SARS-CoV-2 variants in liver transplant recipients

Author

Tomiyama, Takahiro, primary, Suzuki, Rigel, additional, Harada, Noboru, additional, Tamura, Tomokazu, additional, Toshida, Katsuya, additional, Kosai-Fujimoto, Yukiko-, additional, Tomino, Takahiro, additional, Yoshiya, Shohei, additional, Nagao, Yoshihiro, additional, Takeishi, Kazuki, additional, Itoh, Shinji, additional, Kobayashi, Nobuhiro, additional, Ito, Hayato, additional, Yoshio, Sachiyo, additional, Kanto, Tatsuya, additional, Yoshizumi, Tomoharu, additional, and Fukuhara, Takasuke, additional

Published
2023
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42. Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids

Author

Hashimoto, Rina, primary, Tamura, Tomokazu, additional, Watanabe, Yukio, additional, Sakamoto, Ayaka, additional, Yasuhara, Naoko, additional, Ito, Hayato, additional, Nakano, Masahiro, additional, Fuse, Hiromitsu, additional, Ohta, Akira, additional, Noda, Takeshi, additional, Matsumura, Yasufumi, additional, Nagao, Miki, additional, Yamamoto, Takuya, additional, Fukuhara, Takasuke, additional, and Takayama, Kazuo, additional

Published
2023
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45. Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay

Author

Nasser, Hesham, primary, Shimizu, Ryo, additional, Ito, Jumpei, additional, Saito, Akatsuki, additional, Sato, Kei, additional, Ikeda, Terumasa, additional, Matsuno, Keita, additional, Nao, Naganori, additional, Sawa, Hirofumi, additional, Kishimoto, Mai, additional, Tanaka, Shinya, additional, Tsuda, Masumi, additional, Wang, Lei, additional, Oda, Yoshikata, additional, Kato, Marie, additional, Ferdous, Zannatul, additional, Mouri, Hiromi, additional, Shishido, Kenji, additional, Fukuhara, Takasuke, additional, Tamura, Tomokazu, additional, Suzuki, Rigel, additional, Ito, Hayato, additional, Yamasoba, Daichi, additional, Kimura, Izumi, additional, Misawa, Naoko, additional, Uriu, Keiya, additional, Kosugi, Yusuke, additional, Fujita, Shigeru, additional, Suganami, Mai, additional, Chiba, Mika, additional, Yoshimura, Ryo, additional, Nakagawa, So, additional, Wu, Jiaqi, additional, Takaori-Kondo, Akifumi, additional, Shirakawa, Kotaro, additional, Nagata, Kayoko, additional, Kazuma, Yasuhiro, additional, Nomura, Ryosuke, additional, Horisawa, Yoshihito, additional, Tashiro, Yusuke, additional, Kawai, Yugo, additional, Irie, Takashi, additional, Kawabata, Ryoko, additional, Begum, MST Monira, additional, Takahashi, Otowa, additional, Ichihara, Kimiko, additional, Ueno, Takamasa, additional, Motozono, Chihiro, additional, Toyoda, Mako, additional, Tanaka, Yuri L., additional, Butlertanaka, Erika P., additional, Shofa, Maya, additional, Takayama, Kazuo, additional, Hashimoto, Rina, additional, Deguchi, Sayaka, additional, Hashiguchi, Takao, additional, Suzuki, Tateki, additional, Kimura, Kanako, additional, Sasaki, Jiei, additional, Nakajima, Yukari, additional, and Tabata, Kaori, additional

Published
2022
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46. Smoking enhances the expression of angiotensin‐converting enzyme 2 involved in the efficiency of severe acute respiratory syndrome coronavirus 2 infection

Author

Suzuki, Rigel, primary, Ono, Yuki, additional, Noshita, Koji, additional, Kim, Kwang Su, additional, Ito, Hayato, additional, Morioka, Yuhei, additional, Tamura, Tomokazu, additional, Okuzaki, Daisuke, additional, Tagawa, Tetsuzo, additional, Takenaka, Tomoyoshi, additional, Yoshizumi, Tomoharu, additional, Shimamura, Teppei, additional, Iwami, Shingo, additional, and Fukuhara, Takasuke, additional

Published
2022
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47. FUS regulates RAN translation through modulating the G-quadruplex structure of GGGGCC repeat RNA inC9orf72-linked ALS/FTD

Author

Fujino, Yuzo, primary, Ueyama, Morio, additional, Ishiguro, Taro, additional, Ozawa, Daisaku, additional, Ito, Hayato, additional, Sugiki, Toshihiko, additional, Murata, Asako, additional, Ishiguro, Akira, additional, Gendron, Tania F., additional, Mori, Kohji, additional, Tokuda, Eiichi, additional, Taminato, Tomoya, additional, Konno, Takuya, additional, Koyama, Akihide, additional, Kawabe, Yuya, additional, Takeuchi, Toshihide, additional, Furukawa, Yoshiaki, additional, Fujiwara, Toshimichi, additional, Ikeda, Manabu, additional, Mizuno, Toshiki, additional, Mochizuki, Hideki, additional, Mizusawa, Hidehiro, additional, Wada, Keiji, additional, Ishikawa, Kinya, additional, Onodera, Osamu, additional, Nakatani, Kazuhiko, additional, Petrucelli, Leonard, additional, Taguchi, Hideki, additional, and Nagai, Yoshitaka, additional

Published
2022
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50. Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

Author

Kimura, Izumi, primary, Yamasoba, Daichi, additional, Tamura, Tomokazu, additional, Nao, Naganori, additional, Suzuki, Tateki, additional, Oda, Yoshitaka, additional, Mitoma, Shuya, additional, Ito, Jumpei, additional, Nasser, Hesham, additional, Zahradnik, Jiri, additional, Uriu, Keiya, additional, Fujita, Shigeru, additional, Kosugi, Yusuke, additional, Wang, Lei, additional, Tsuda, Masumi, additional, Kishimoto, Mai, additional, Ito, Hayato, additional, Suzuki, Rigel, additional, Shimizu, Ryo, additional, Begum, MST Monira, additional, Yoshimatsu, Kumiko, additional, Kimura, Kanako Terakado, additional, Sasaki, Jiei, additional, Sasaki-Tabata, Kaori, additional, Yamamoto, Yuki, additional, Nagamoto, Tetsuharu, additional, Kanamune, Jun, additional, Kobiyama, Kouji, additional, Asakura, Hiroyuki, additional, Nagashima, Mami, additional, Sadamasu, Kenji, additional, Yoshimura, Kazuhisa, additional, Shirakawa, Kotaro, additional, Takaori-Kondo, Akifumi, additional, Kuramochi, Jin, additional, Schreiber, Gideon, additional, Ishii, Ken J., additional, Hashiguchi, Takao, additional, Ikeda, Terumasa, additional, Saito, Akatsuki, additional, Fukuhara, Takasuke, additional, Tanaka, Shinya, additional, Matsuno, Keita, additional, and Sato, Kei, additional

Published
2022
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