Search

Your search keyword '"Itoh, Reina E."' showing total 11 results
Start Over Author "Itoh, Reina E."
11 results on '"Itoh, Reina E."'

6. Age-dependent deterioration of locomotion inDrosophila melanogasterdeficient in the homologue ofamyotrophic lateral sclerosis 2

Author

80213396, Takayama, Yuta, Itoh, Reina E., Tsuyama, Taiichi, Uemura, Tadashi, 80213396, Takayama, Yuta, Itoh, Reina E., Tsuyama, Taiichi, and Uemura, Tadashi

Abstract

Recessive mutations in the amyotrophic lateral sclerosis 2 (ALS2) gene have been linked to juvenile-onset ALS2. Although one of the molecular functions of the ALS2 protein is clearly the activation of Rab5, the mechanisms underlying the selective dysfunction and degeneration of motor neurons in vivo remain to be fully understood. Here, we focused on the ALS2 homologue of Drosophila melanogaster, isolated two independent deletions, and systematically compared phenotypes of the mutants with those of animals in which Rab5 function in identified neurons was abrogated. In the dALS2 mutant flies, we found that the stereotypic axonal and dendritic morphologies of neurons shared some features with those in Rab5-deficient flies, but the dALS2 mutant phenotypes were much milder. We also found that the abrogation of Rab5 function in motor neurons strongly depressed the locomotion activity of adults, resembling the behavior of aged dALS2 mutants. Importantly, this age-dependent locomotion deficit of dALS2 mutants was restored to normal by expressing the dALS2 transgene in a wide range of tissues. This finding provided a platform where we could potentially identify particular cell types responsible for the phenotype by tissue-specific rescue experiments. We discuss our results and the future usage of the dALS2 mutant as a new ALS model.

Published
2014

8. The Rho-mDia1 Pathway Regulates Cell Polarity and Focal Adhesion Turnover in Migrating Cells through Mobilizing Apc and c-Src

Author

Yamana, Norikazu, primary, Arakawa, Yoshiki, additional, Nishino, Tomohiro, additional, Kurokawa, Kazuo, additional, Tanji, Masahiro, additional, Itoh, Reina E., additional, Monypenny, James, additional, Ishizaki, Toshimasa, additional, Bito, Haruhiko, additional, Nozaki, Kazuhiko, additional, Hashimoto, Nobuo, additional, Matsuda, Michiyuki, additional, and Narumiya, Shuh, additional

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results