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3 results on '"Ivelina Himcheva"'

1. Involvement of the opioidergic and nociceptinergic systems in the analgesic effects of novel nociceptin analogues after acute and chronic immobilization stress

Author

Ivelina Himcheva, Galya Tz. Stavreva, Emilia Naydenova, and Adriana Bocheva

Subjects
Pharmacy and materia medica, RS1-441
Abstract

Stress is known to exert an influence on neuroendocrine, autonomic, hormonal functioning. Various stress models have been reported to induce analgesia. This is a phenomenon, referred to as stress-induced analgesia (SIA). Nociceptin/Orphanin FQ(N/OFQ) is a heptadecapeptide that has been found to play a direct role on pain perception. This study aimed to investigate the effects of novel nociceptin analogues on nociception after acute and chronic immobilization stress (CIS) and the involvement of the opioid and nociceptinergic systems in analgesic effects. Analgesic effects were examined by paw-pressure (PP) and hot-plate (HP) tests. Our data showed that acute immobilization stress induced hypoalgesia. The analgesic effect was more pronounced in pain caused by a mechanical stimulus than by a thermal one. CIS attenuated the hyperalgesic effect of naloxone and JTC-801 for mechanical and thermal stimulation. The effects of the opioid system are more pronounced in acute immobilization stress, while the nociceptin mechanisms predominate after chronic stress.

Published
2022
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2. Assessment of Vitamin D Status and Calcium-Phosphorus Metabolism in Postmenopausal Women with Osteoporosis

Author

Tatyana Nedkova Simeonova, A. Dimitrova, Ivelina Himcheva, Krasimira Stefanova, Boryana Ruseva, and Pavlina Yordanova-Laleva

Subjects
lcsh:R5-920, medicine.medical_specialty, Postmenopausal women, business.industry, Osteoporosis, insufficiency and deficiency of vitamin d, insufficiency and deficiency of vitamin D, Metabolism, Postmenopausal osteoporosis, medicine.disease, lcsh:RK1-715, postmenopausal osteoporosis, Endocrinology, lcsh:Dentistry, Internal medicine, medicine, Vitamin D and neurology, Calcium phosphorus, lcsh:Medicine (General), business, General Dentistry
Abstract

This study aims to assess vitamin D levels in women with postmenopausal osteoporosis and healthy women in menopause. Two groups of women over 50 years of age took part in the study – 41 women with osteoporosis and 22 without osteoporosis. The levels of vitamin D, parathormone, alkaline phosphatase, calcium and phosphorus were examined. 16 women with osteoporosis (39%) were with normal levels of vitamin D, 14 (34,1%) were with insufficiency, and 11 (26,9%) with deficiency of vitamin D. Within the control group, 8 women (36,4%) were with normal levels of vitamin D, 12 (54,5%) were with vitamin D insufficiency and 2 (9,1%) with deficiency. The patients with vitamin D deficiency were significantly older both in the osteoporosis group and the control group (r = -0.32, p

Published
2020

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