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Laparoscopic ventral hernia repair with intraperitoneal onlay mesh reinforcement is often performed in clinical practice. We herein describe a patient who developed a Spigelian hernia at the edge of the mesh due to rupture of the muscular layer in the abdominal wall. A 69-year-old woman developed a left-sided abdominal bulge 15 months after laparoscopic ventral hernia repair. CT showed a 33-mm defect in the abdominal wall at the lateral edge of the left abdominal rectus muscle with an intestinal prolapse through the defect. She was diagnosed with a Spigelian hernia and underwent operation. The hernia orifice was located at the aponeurosis of the transverse abdominal muscle where the thread had been used to fix the mesh through all layers of the abdominal wall. This report details a case of a Spigelian hernia after laparoscopic ventral hernia repair.

A 70-year-old man had undergone thoracoscopic esophagectomy following neoadjuvant chemotherapy for thoracic esophageal squamous cell carcinoma 3 years before presentation. He was undergoing whole-brain irradiation following surgery for a solitary brain metastatic tumor. The chief complaint was left leg pain during irradiation. FDG-PET/CT and MRI revealed metastases in bilateral cauda equina S1 nerve roots. Cerebrospinal fluid examination also revealed malignant cells. He received chemotherapy with 2 courses of 5-fluorouracil and cisplatin following 30 Gy of spinal irradiation. To control neurological symptoms, 4 courses of intrathecal chemotherapy with methotrexate, cytarabine, and betamethasone were performed. However, he gradually weakened and died 8 months after brain metastasis and 7 months after leptomeningeal carcinomatosis. The multidisciplinary treatment using irradiation and systemic and intrathecal chemotherapies could improve the survival of patients with leptomeningeal carcinomatosis of esophageal squamous cell carcinoma.

The Sea of Japan has existed since Early Miocene time and the environmental conditions have changed during the Neogene and Quaternary geographically and oceanographically. The history of the Sea of Japan is generally divided into six stages, 1) the age of continental margin (Paleogene to Early Miocene), 2) the age of inception of a marginal sea and great transgression (late Early Miocene to Early/Middle Miocene), 3) the age of deepening sea (Middle Miocene), 4) the age of deep sea (Middle to Late Miocene), 5) the age of formation of present marginal sea (late Late Miocene/Early Pliocene) and 6) the age of present marginal sea (Late Pliocene to Recent). In the second stage the coastal shallow sea was mainly covered by tropical and subtropical elements of marine macrofaunas. In the fourth stage marine faunas and floras changed mainly to temperate elements of Pacific Ocean with rare subtropical elements. Between the fourth and fifth stages the shift of species in various taxa was well recognized. In the fifth and sixth stages the migration of marine organisms was actively carried out from the southern and northern seas. The change of marine macrofaunas were strongly effected by the exchange of warm and cold sea currents, and the appearance and disappearance of land-bridges and straits with the sea level changes caused by climatic and crustal movements.

Supplemental doses of antithrombin (AT) are widely used to treat sepsis-induced disseminated intravascular coagulation (DIC) in Japan. However, evidence on the benefits of AT supplementation for DIC is insufficient. This multicenter retrospective observational study aimed to clarify the effect of AT supplementation on sepsis-induced DIC using propensity score analyses. Data from 3,195 consecutive adult patients admitted to 42 intensive care units for severe sepsis treatment were retrospectively analyzed; 1,784 patients were diagnosed with DIC (n = 715, AT group; n = 1,069, control group). Inverse probability of treatment-weighted propensity score analysis indicated a statistically significant association between AT supplementation and lower in-hospital all-cause mortality (n = 1,784, odds ratio [95% confidence intervals]: 0.748 [0.572-0.978], P = 0.034). However, quintile-stratified propensity score analysis (n = 1,784, odds ratio: 0.823 [0.646-1.050], P = 0.117) and propensity score matching analysis (461 matching pairs, odds ratio: 0.855 [0.649-1.125], P = 0.263) did not show this association. In the early days after intensive care unit admission, the survival rate was statistically higher in the propensity score-matched AT group than in the propensity score-matched control group (P = 0.007). In DIC patients without concomitant heparin administration, similar results were observed. In conclusion, AT supplementation may be associated with reduced in-hospital all-cause mortality in patients with sepsis-induced DIC. However, the statistical robustness of this connection was not strong. In addition, although the number of transfusions needed in patients with AT supplementation increased, severe bleeding complications did not.

Grade 2 or 3 proteinuria was observed in 54 patients out of 158 metastatic colorectal cancer patients receiving anti-VEGF therapy. Patients with diabetes and hypertension were risk for severe proteinuria. ARBs were more frequently used in patients with severe proteinuria. However, they could not reduce proteinuria. The examination of protein/creatinine ratio was useful for continuing anti-VEGF therapy.

In this work-in-progress paper, we examined a calibration-free eye tracking system for the education of students with severe physical and intellectual disabilities. The authors' system design yielded an implemented system that was applied experimentally to three students to evaluate the system's educational effects and possibilities.

We describe a procedure for constructing a website for publishing open data by focusing on the case of Open DATA METI, a website of the Ministry of Economy, Trade, and Industry of Japan. We developed two sites for publishing open data: a data catalog site and one for searching linked open data (LOD). The former allows users to find relevant data they want to use, and the latter allows them to utilize the found data by connecting them. To implement the data catalog site, we constructed a site tailored to the needs of the organization. Then we extracted a large amount of metadata from the individual open data and put it on the site. These activities would have taken a lot of time if we had used the existing methods, so we devised our own solutions for them. To implement the LOD searching site, we converted the data into LOD in the Resource Description Framework (RDF). We focused on converting statistical data into tables, which are widely used. Regarding the conversion, there were several kinds of missing information that we needed to associate with the data in the tables. We created a template for incorporating the necessary information for LOD in the original table. The conversion into LOD was automatically done using the template.