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3. Swiping right on PrEP: a qualitative study of MSM preferences for PrEP public health messaging on dating apps.

Author

Adan, Matthew A., Psaros, Christina, Chamberlin, Grace, Zionts, Dani, Iyer, Surabhi, Platt, Laura, Lopes, Mairead Day, Medeiros, Susana, O'Connor, Catherine, Bassett, Ingrid V., and Ard, Kevin L.

Subjects
HIV prevention, MOBILE apps, HEALTH literacy, SATISFACTION, QUALITATIVE research, FOCUS groups, RESEARCH funding, INTERVIEWING, MOBILE hospitals, CONTENT analysis, HEALTH, DATING (Social customs), INFORMATION resources, MEN who have sex with men, PRE-exposure prophylaxis, ADVERTISING, SPANISH language, PUBLIC health, TEXT messages, HEALTH promotion, SEXUAL health, ACCESS to information
Abstract

Men who have sex with men (MSM) are disproportionately affected by HIV. Given that over 70% of MSM meet sexual partners via dating apps, such apps may be an effective platform for promoting HIV pre-exposure prophylaxis (PrEP) use. We aimed to describe preferences among MSM for PrEP advertisements displayed on dating apps. We conducted individual in-depth interviews with 16 MSM recruited from a mobile sexual health unit in Boston, Massachusetts. Two focus groups were also held: one with mobile unit staff (N = 3) and one with mobile unit users (N = 3). Content analysis was used to identify themes related to advertisement content and integration with app use. Mean participant age was 28 (SD 6.8); 37% identified as White and 63% as Latinx. 21% of interviews were conducted in Spanish. Preferences were organized around four themes: (1) relevant and relatable advertisements, (2) expansion of target audiences to promote access, (3) concise and captivating advertisements, and (4) PrEP advertisements and services as options, not obligations. MSM are supportive of receiving information about PrEP on dating apps, but feel that existing advertisements require modification to better engage viewers. Dating apps may be an underutilized tool for increasing PrEP awareness and knowledge among MSM. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant

Author

Seaman, Michael S., primary, Siedner, Mark J., additional, Boucau, Julie, additional, Lavine, Christy L., additional, Ghantous, Fadi, additional, Liew, May Y., additional, Mathews, Josh I., additional, Singh, Arshdeep, additional, Marino, Caitlin, additional, Regan, James, additional, Uddin, Rockib, additional, Choudhary, Manish C., additional, Flynn, James P., additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M., additional, Lipiner, Taryn, additional, Kittilson, Autumn, additional, Melberg, Meghan, additional, Gilbert, Rebecca F., additional, Reynolds, Zahra, additional, Iyer, Surabhi L., additional, Chamberlin, Grace C., additional, Vyas, Tammy D., additional, Vyas, Jatin M., additional, Goldberg, Marcia B., additional, Luban, Jeremy, additional, Li, Jonathan Z., additional, Barczak, Amy K., additional, and Lemieux, Jacob E., additional

Published
2022
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6. Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection

Author

Boucau, Julie, primary, Marino, Caitlin, additional, Regan, James, additional, Uddin, Rockib, additional, Choudhary, Manish C., additional, Flynn, James P., additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M., additional, Mathews, Josh, additional, Liew, May Y., additional, Singh, Arshdeep, additional, Lipiner, Taryn, additional, Kittilson, Autumn, additional, Melberg, Meghan, additional, Li, Yijia, additional, Gilbert, Rebecca F., additional, Reynolds, Zahra, additional, Iyer, Surabhi L., additional, Chamberlin, Grace C., additional, Vyas, Tammy D., additional, Goldberg, Marcia B., additional, Vyas, Jatin M., additional, Li, Jonathan Z., additional, Lemieux, Jacob E., additional, Siedner, Mark J., additional, and Barczak, Amy K., additional

Published
2022
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7. Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19)

Author

Boucau, Julie, primary, Uddin, Rockib, additional, Marino, Caitlin, additional, Regan, James, additional, Flynn, James P, additional, Choudhary, Manish C, additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M, additional, Mathews, Josh, additional, Liew, May Y, additional, Singh, Arshdeep, additional, Reynolds, Zahra, additional, Iyer, Surabhi L, additional, Chamberlin, Grace C, additional, Vyas, Tammy D, additional, Vyas, Jatin M, additional, Turbett, Sarah E, additional, Li, Jonathan Z, additional, Lemieux, Jacob E, additional, Barczak, Amy K, additional, and Siedner, Mark J, additional

Published
2022
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8. Virologic characterization of symptom rebound following nirmatrelvir-ritonavir treatment for COVID-19

Author

Boucau, Julie, primary, Uddin, Rockib, additional, Marino, Caitlin, additional, Regan, James, additional, Flynn, James P., additional, Choudhary, Manish C., additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M., additional, Mathews, Josh, additional, Liew, May Y., additional, Singh, Arshdeep, additional, Reynolds, Zahra, additional, Iyer, Surabhi L., additional, Chamberlin, Grace C., additional, Vyas, Tammy D., additional, Vyas, Jatin M., additional, Turbett, Sarah E., additional, Li, Jonathan Z., additional, Lemieux, Jacob E., additional, Barczak, Amy K., additional, and Siedner, Mark J., additional

Published
2022
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9. Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses

Author

Seaman, Michael S., primary, Siedner, Mark J., additional, Boucau, Julie, additional, Lavine, Christy L., additional, Ghantous, Fadi, additional, Liew, May Y., additional, Mathews, Josh, additional, Singh, Arshdeep, additional, Marino, Caitlin, additional, Regan, James, additional, Uddin, Rockib, additional, Choudhary, Manish C., additional, Flynn, James P., additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M., additional, Lipiner, Taryn, additional, Kittilson, Autumn, additional, Melberg, Meghan, additional, Gilbert, Rebecca F., additional, Reynolds, Zahra, additional, Iyer, Surabhi L., additional, Chamberlin, Grace C., additional, Vyas, Tammy D., additional, Vyas, Jatin M., additional, Goldberg, Marcia B., additional, Luban, Jeremy, additional, Li, Jonathan Z., additional, Barczak, Amy K., additional, and Lemieux, Jacob E., additional

Published
2022
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10. Duration of viable virus shedding in SARS-CoV-2 omicron variant infection

Author

Boucau, Julie, primary, Marino, Caitlin, additional, Regan, James, additional, Uddin, Rockib, additional, Choudhary, Manish C., additional, Flynn, James P., additional, Chen, Geoffrey, additional, Stuckwisch, Ashley M., additional, Mathews, Josh, additional, Liew, May Y., additional, Singh, Arshdeep, additional, Lipiner, Taryn, additional, Kittilson, Autumn, additional, Melberg, Meghan, additional, Li, Yijia, additional, Gilbert, Rebecca F., additional, Reynolds, Zahra, additional, Iyer, Surabhi L., additional, Chamberlin, Grace C., additional, Vyas, Tammy D., additional, Goldberg, Marcia B., additional, Vyas, Jatin M., additional, Li, Jonathan Z., additional, Lemieux, Jacob E., additional, Siedner, Mark J., additional, and Barczak, Amy K., additional

Published
2022
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11. Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections

Author

Siedner, Mark J., primary, Boucau, Julie, additional, Gilbert, Rebecca F., additional, Uddin, Rockib, additional, Luu, Jonathan, additional, Haneuse, Sebastien, additional, Vyas, Tammy, additional, Reynolds, Zahra, additional, Iyer, Surabhi, additional, Chamberlin, Grace C., additional, Goldstein, Robert H., additional, North, Crystal M., additional, Sacks, Chana A., additional, Regan, James, additional, Flynn, James P., additional, Choudhary, Manish C., additional, Vyas, Jatin M., additional, Barczak, Amy K., additional, Lemieux, Jacob E., additional, and Li, Jonathan Z., additional

Published
2022
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12. Characterization of Virologic Rebound Following Nirmatrelvir-Ritonavir Treatment for Coronavirus Disease 2019 (COVID-19).

Author

Boucau, Julie, Uddin, Rockib, Marino, Caitlin, Regan, James, Flynn, James P, Choudhary, Manish C, Chen, Geoffrey, Stuckwisch, Ashley M, Mathews, Josh, Liew, May Y, Singh, Arshdeep, Reynolds, Zahra, Iyer, Surabhi L, Chamberlin, Grace C, Vyas, Tammy D, Vyas, Jatin M, Turbett, Sarah E, Li, Jonathan Z, Lemieux, Jacob E, and Barczak, Amy K

Subjects
REVERSE transcriptase polymerase chain reaction, COVID-19, COMBINATION drug therapy, SEQUENCE analysis, ANTIVIRAL agents, RITONAVIR, DESCRIPTIVE statistics, GENOMES, VIROLOGY, DATA analysis software, LONGITUDINAL method
Abstract

We enrolled 7 individuals with recurrent symptoms or antigen test conversion following nirmatrelvir-ritonavir treatment. High viral loads (median 6.1 log10 copies/mL) were detected after rebound for a median of 17 days after initial diagnosis. Three had culturable virus for up to 16 days after initial diagnosis. No known resistance-associated mutations were identified. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Duration of viral shedding and culture positivity with post-vaccination breakthrough delta variant infections

Author

Siedner, Mark J., primary, Boucau, Julie, additional, Gilbert, Rebecca, additional, Uddin, Rockib, additional, Luu, Jonathan, additional, Haneuse, Sebastien, additional, Vyas, Tammy, additional, Reynolds, Zahra, additional, Iyer, Surabhi, additional, Chamberlin, Grace, additional, Goldstein, Robert H., additional, North, Crystal M., additional, Sacks, Chana A., additional, Regan, James, additional, Flynn, James P., additional, Choudhary, Manish Chandra, additional, Vyas, Jatin M., additional, Barczak, Amy K., additional, Lemieux, Jacob, additional, and Li, Jonathan Z., additional

Published
2021
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19. Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses.

Author

Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews J, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, and Lemieux JE

Abstract

There is increasing evidence that the risk of SARS-CoV-2 infection among vaccinated individuals is variant-specific, suggesting that protective immunity against SARS-CoV-2 may differ by variant. We enrolled vaccinated (n = 39) and unvaccinated (n = 11) individuals with acute, symptomatic SARS-CoV-2 Delta or Omicron infection and performed SARS-CoV-2 viral load quantification, whole-genome sequencing, and variant-specific antibody characterization at the time of acute illness and convalescence. Viral load at the time of infection was inversely correlated with antibody binding and neutralizing antibody responses. Increases in antibody titers and neutralizing activity occurred at convalescence in a variant-specific manner. Across all variants tested, convalescent neutralization titers in unvaccinated individuals were markedly lower than in vaccinated individuals. For individuals infected with the Delta variant, neutralizing antibody responses were weakest against BA.2, whereas infection with Omicron BA.1 variant generated a broader response against all tested variants, including BA.2.

Published
2022
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20. Duration of viable virus shedding in SARS-CoV-2 omicron variant infection.

Author

Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Lipiner T, Kittilson A, Melberg M, Li Y, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Goldberg MB, Vyas JM, Li JZ, Lemieux JE, Siedner MJ, and Barczak AK

Abstract

Clinical features of SARS-CoV-2 Omicron variant infection, including incubation period and transmission rates, distinguish this variant from preceding variants. However, whether the duration of shedding of viable virus differs between omicron and previous variants is not well understood. To characterize how variant and vaccination status impact shedding of viable virus, we serially sampled symptomatic outpatients newly diagnosed with COVID-19. Anterior nasal swabs were tested for viral load, sequencing, and viral culture. Time to PCR conversion was similar between individuals infected with the Delta and the Omicron variant. Time to culture conversion was also similar, with a median time to culture conversion of 6 days (interquartile range 4-8 days) in both groups. There were also no differences in time to PCR or culture conversion by vaccination status.

Published
2022
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