Search

Your search keyword '"Izquierdo, SM"' showing total 9 results
Start Over Author "Izquierdo, SM"
9 results on '"Izquierdo, SM"'

1. A global experiment on motivating social distancing during the COVID-19 pandemic

Author

Legate, N, Nguyen, TV, Weinstein, N, Moller, A, Legault, L, Vally, Z, Tajchman, Z, Zsido, AN, Zrimsek, M, Chen, Z, Ziano, I, Gialitaki, Z, Basnight-Brown, DM, Ceary, CD, Jang, Y, IJzerman, H, Lin, Y, Kunisato, Y, Yamada, Y, Xiao, Q, Jiang, X, Du, X, Yao, E, Ryan, WS, Wilson, JP, Cyrus-Lai, W, Jimenez-Leal, W, Law, W, Unanue, W, Collins, WM, Richard, KL, Vranka, M, Ankushev, V, Schei, V, Lerche, V, Kovic, V, Krizanic, V, Kadreva, VH, Adoric, VC, Tran, US, Yeung, SK, Hassan, W, Houston, R, Urry, HL, Machin, MA, Lima, TJS, Ostermann, T, Frizzo, T, Sverdrup, TE, House, T, Gill, T, Fedotov, M, Paltrow, T, Moshontz, H, Jernsäther, T, Rahman, T, Machin, T, Koptjevskaja-Tamm, M, Hostler, TJ, Ishii, T, Szaszi, B, Adamus, S, Suter, L, Von Bormann, SM, Habib, S, Studzinska, A, Stojanovska, D, Janssen, SMJ, Stieger, S, Primbs, MA, Schulenberg, SE, Buchanan, EM, Tatachari, S, Azouaghe, S, Sorokowski, P, Sorokowska, A, Song, X, Morbée, S, Lewis, S, Sinkolova, S, Grigoryev, D, Drexler, SM, Daches, S, Levine, SL, Geniole, SN, Akter, S, Vracar, S, Massoni, S, Costa, S, Zorjan, S, Sarioguz, E, Izquierdo, SM, Tshonda, SS, Miller, JK, Alves, SG, Pöntinen, S, Solas, SÁ, Ordoñez-Riaño, S, Ocovaj, SB, Onie, S, Legate, N, Nguyen, TV, Weinstein, N, Moller, A, Legault, L, Vally, Z, Tajchman, Z, Zsido, AN, Zrimsek, M, Chen, Z, Ziano, I, Gialitaki, Z, Basnight-Brown, DM, Ceary, CD, Jang, Y, IJzerman, H, Lin, Y, Kunisato, Y, Yamada, Y, Xiao, Q, Jiang, X, Du, X, Yao, E, Ryan, WS, Wilson, JP, Cyrus-Lai, W, Jimenez-Leal, W, Law, W, Unanue, W, Collins, WM, Richard, KL, Vranka, M, Ankushev, V, Schei, V, Lerche, V, Kovic, V, Krizanic, V, Kadreva, VH, Adoric, VC, Tran, US, Yeung, SK, Hassan, W, Houston, R, Urry, HL, Machin, MA, Lima, TJS, Ostermann, T, Frizzo, T, Sverdrup, TE, House, T, Gill, T, Fedotov, M, Paltrow, T, Moshontz, H, Jernsäther, T, Rahman, T, Machin, T, Koptjevskaja-Tamm, M, Hostler, TJ, Ishii, T, Szaszi, B, Adamus, S, Suter, L, Von Bormann, SM, Habib, S, Studzinska, A, Stojanovska, D, Janssen, SMJ, Stieger, S, Primbs, MA, Schulenberg, SE, Buchanan, EM, Tatachari, S, Azouaghe, S, Sorokowski, P, Sorokowska, A, Song, X, Morbée, S, Lewis, S, Sinkolova, S, Grigoryev, D, Drexler, SM, Daches, S, Levine, SL, Geniole, SN, Akter, S, Vracar, S, Massoni, S, Costa, S, Zorjan, S, Sarioguz, E, Izquierdo, SM, Tshonda, SS, Miller, JK, Alves, SG, Pöntinen, S, Solas, SÁ, Ordoñez-Riaño, S, Ocovaj, SB, and Onie, S

Abstract

Finding communication strategies that effectively motivate social distancing continues to be a global public health priority during the COVID-19 pandemic. This crosscountry, preregistered experiment (n = 25,718 from 89 countries) tested hypotheses concerning generalizable positive and negative outcomes of social distancing messages that promoted personal agency and reflective choices (i.e., an autonomy-supportive message) or were restrictive and shaming (i.e., a controlling message) compared with no message at all. Results partially supported experimental hypotheses in that the controlling message increased controlled motivation (a poorly internalized form of motivation relying on shame, guilt, and fear of social consequences) relative to no message. On the other hand, the autonomy-supportive message lowered feelings of defiance compared with the controlling message, but the controlling message did not differ from receiving no message at all. Unexpectedly, messages did not influence autonomous motivation (a highly internalized form of motivation relying on one's core values) or behavioral intentions. Results supported hypothesized associations between people's existing autonomous and controlled motivations and self-reported behavioral intentions to engage in social distancing. Controlled motivation was associated with more defiance and less long-term behavioral intention to engage in social distancing, whereas autonomous motivation was associated with less defiance and more short- and long-term intentions to social distance. Overall, this work highlights the potential harm of using shaming and pressuring language in public health communication, with implications for the current and future global health challenges.

Published
2022

2. Functional Analysis of Contextually Inappropriate Social Behavior in Children With Down Syndrome.

Author

Izquierdo SM, Jessel J, Fiani T, and Jones EA

Subjects
Child, Humans, Child, Preschool, Social Behavior, Attention, Problem Behavior, Down Syndrome
Abstract

Background: Children with Down syndrome often engage in contextually inappropriate social behavior, which researchers suggest may function to escape from difficult activities to preferred social interactions. Caregivers may reinforce the behavior, perceiving it only as evidence of the child's social strength, when, in fact, the pattern may also prevent or slow the development of critical skills. Unlike overt forms of challenging behavior, contextually inappropriate social behavior had never been subjected to experimental analysis., Aims: The purpose of the current study was to identify and demonstrate functional control of contextually inappropriate social behavior to caregiver-informed contingencies., Method and Procedures: We interviewed caregivers and subjected contextually inappropriate social behavior to functional analyses for nine young children with Down syndrome., Outcomes and Results: We found sensitivity to the caregiver-informed contingencies for all nine participants with strong functional control and large effect sizes for most., Conclusions and Implications: Caregivers may not perceive contextually inappropriate social behavior as problematic, yet patterns of contextually inappropriate and other problem behaviors suggest decreased engagement and poor task persistence. Assessments that lead to intervention decisions may be more informative when they include questions about social topographies of behavior not typically considered as problematic. Once caregivers are aware of the pattern, they may be better prepared to intervene., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Published
2024
Full Text
View/download PDF

3. In COVID-19 Health Messaging, Loss Framing Increases Anxiety with Little-to-No Concomitant Benefits: Experimental Evidence from 84 Countries.

Author

Dorison CA, Lerner JS, Heller BH, Rothman AJ, Kawachi II, Wang K, Rees VW, Gill BP, Gibbs N, Ebersole CR, Vally Z, Tajchman Z, Zsido AN, Zrimsek M, Chen Z, Ziano I, Gialitaki Z, Ceary CD, Lin Y, Kunisato Y, Yamada Y, Xiao Q, Jiang X, Du X, Yao E, Wilson JP, Cyrus-Lai W, Jimenez-Leal W, Law W, Collins WM, Richard KL, Vranka M, Ankushev V, Schei V, Križanić V, Kadreva VH, Adoric VC, Tran US, Yeung SK, Hassan W, Houston R, Lima TJS, Ostermann T, Frizzo T, Sverdrup TE, House T, Gill T, Fedotov M, Paltrow T, Jernsäther T, Koptjevskaja-Tamm M, Hostler TJ, Ishii T, Szaszi B, Adamus S, Suter L, Habib S, Studzinska A, Stojanovska D, Janssen SMJ, Stieger S, Schulenberg SE, Tatachari S, Azouaghe S, Sorokowski P, Sorokowska A, Song X, Lewis SC, Sinkolova S, Grigoryev D, Drexler SM, Daches S, Geniole SN, Vračar S, Massoni S, Zorjan S, Sarıoğuz E, Izquierdo SM, Alves SG, Pöntinen S, Solas SÁ, Ordoñez-Riaño S, Očovaj SB, Onie S, Lins S, Çoksan S, Sacakli A, Ruiz-Fernández S, Geiger SJ, FatahModares S, Walczak RB, Betlehem R, Vilar R, Cárcamo R, Ross RM, McCarthy R, Ballantyne T, Westgate EC, Afhami R, Ren D, Monteiro RP, Reips UD, Reggev N, Calin-Jageman RJ, Pourafshari R, Oliveira R, Nedelcheva-Datsova M, Rahal RM, Ribeiro RR, Radtke T, Searston R, Habte R, Zdybek P, Chen SC, Maturan PLG, Perillo JT, Isager PM, Kačmár P, Macapagal PM, Szwed P, Hanel PHP, Forbes PAG, Arriaga P, Paris B, Papachristopoulos K, Correa PS, Kácha O, Bernardo M, Campos O, Bravo ON, Galindo-Caballero OJ, Ogbonnaya CE, Bialobrzeska O, Kiselnikova N, Simonovic N, Cohen N, Nock NL, Johannes N, Albayrak-Aydemir N, Say N, Torunsky N, Van Doren N, Sunami N, Rachev NR, Majeed NM, Schmidt ND, Nadif K, Corral-Frías NS, Ouherrou N, Pantazi M, Lucas MY, Vasilev MR, Ortiz MV, Butt MM, Kabir M, Muda R, Tejada Rivera MDCM, Sirota M, Seehuus M, Parzuchowski M, Toro M, Hricova M, Maldonado MA, Marszalek M, Karekla M, Mioni G, Bosma MJ, Westerlund M, Vdovic M, Bialek M, Silan MA, Anne M, Misiak M, Grinberg M, Capizzi M, Espinoza Barría MF, Kurfali MA, Mensink MC, Harutyunyan M, Khosla M, Korbmacher M, Adamkovič M, Ribeiro MFF, Terskova M, Hruška M, Martončik M, Voracek M, Čadek M, Frías-Armenta M, Kowal M, Topor M, Roczniewska M, Oosterlinck M, Kohlová MB, Paruzel-Czachura M, Romanova M, Papadatou-Pastou M, Lund ML, Antoniadi M, Jones MV, Ortiz MS, Manavalan M, Muminov A, Kossowska M, Friedemann M, Wielgus M, Varella MAC, Colloff MF, Bradford M, Vaughn LA, Eudave L, Vieira L, Pineda LMS, Pérez LC, Lazarevic LB, Jaremka LM, Kushnir E, Anton-Boicuk L, de Holanda Coelho GL, Ahlgren L, Levitan CA, Micheli L, Volz L, Stojanovska M, Boucher L, Samojlenko L, Delgado LGJ, Kaliska L, Warmelink L, Rojas-Berscia LM, Yu K, Wachowicz J, Desai K, Barzykowski K, Kozma L, Evans K, Kirgizova K, Agesin BE, Koehn MA, Wolfe K, Korobova T, Klevjer K, van Schie K, Vezirian K, Damnjanović K, Thommesen KK, Schmidt K, Filip K, Grzech K, Hoyer K, Moon K, Rana K, Janjić K, Suchow JW, Kielińska J, Cruz Vásquez JE, Beitner J, Vargas-Nieto JC, Roxas JCT, Taber J, Urriago-Rayo J, Pavlacic JM, Bavolar J, Soto JA, Olofsson JK, Vilsmeier JK, Messerschmidt J, Czamanski-Cohen J, Boudesseul J, Lee JM, Kamburidis J, Zickfeld J, Miranda JF, Verharen JPH, Hristova E, Beshears JE, Đorđević JM, Bosch J, Valentova JV, Antfolk J, Berkessel JB, Schrötter J, Urban J, Röer JP, Norton JO, Silva JR, Pickering JS, Vintr J, Uttley J, Kunst JR, Ndukaihe ILG, Iyer A, Vilares I, Ivanov A, Ropovik I, Sula I, Sarieva I, Metin-Orta I, Prusova I, Pinto I, Bozdoc AI, Almeida IAT, Pit IL, Dalgar I, Zakharov I, Arinze AI, Ihaya K, Stephen ID, Gjoneska B, Brohmer H, Flowe H, Godbersen H, Kocalar HE, Hedgebeth MV, Chuan-Peng H, Sharifian M, Manley H, Akkas H, Hajdu N, Azab H, Kaminski G, Nilsonne G, Anjum G, Travaglino GA, Feldman G, Pfuhl G, Czarnek G, Marcu GM, Hofer G, Banik G, Adetula GA, Bijlstra G, Verbruggen F, Kung FYH, Foroni F, Singer G, Muchembled F, Azevedo F, Mosannenzadeh F, Marinov E, Štrukelj E, Etebari Z, Baskin E, Garcia EOL, Musser E, van Steenkiste IMM, Ahn ER, Pronizius E, Jackson EA, Manunta E, Agadullina E, Šakan D, Dursun P, Dujols O, Dubrov D, Willis M, Tümer M, Beaudry JL, Popović D, Dunleavy D, Djamai I, Krupić D, Vega D, Du H, Mola D, Davis WE, Holford DL, Lewis DMG, Vaidis DC, Ozery DH, Ricaurte DZ, Storage D, Sousa D, Alvarez DS, Rosa AD, Krupić D, Marko D, Moreau D, Reeck C, Correia RC, Whitt CM, Lamm C, Solorzano CS, von Bastian CC, Sutherland CA, Overkott C, Aberson CL, Wang C, Karashiali C, Noone C, Chiu F, Picciocchi C, Karaarslan C, Cellini N, Esteban-Serna C, Reyna C, Batres C, Li R, Grano C, Carpentier J, Tamnes CK, Fu CHY, Ishkhanyan B, Bylinina L, Jaeger B, Bundt C, Allred TB, Bokkour A, Bogatyreva N, Chopik WJ, Antazo B, Behzadnia B, Becker M, Cocco B, Chou WL, Hubena B, Žuro B, Aczel B, Baklanova E, Bai H, Balci BB, Babinčák P, Dixson BJW, Mokady A, Kappes HB, Atari M, Szala A, Szabelska A, Aruta JJB, Domurat A, Arinze NC, Modena A, Adiguzel A, Monajem A, Arabi KAE, Özdoğru AA, Olaya Torres AJ, Theodoropoulou A, Jurković AP, Kassianos AP, Findor A, Hartanto A, Thibault Landry A, Ferreira A, Santos AC, De la Rosa-Gomez A, Gourdon-Kanhukamwe A, Todsen AL, Karababa A, Janak A, Bran A, Tullett AM, Kuzminska AO, Krafnick AJ, Urooj A, Khaoudi A, Ahmed A, Groyecka-Bernard A, Askelund AD, Adetula A, Belaus A, Charyate AC, Wichman AL, Stoyanova A, Greenburgh A, Thomas AG, Arvanitis A, Forscher PS, Mallik PR, Primbs MA, Miller JK, Moshontz H, Urry HL, IJzerman H, Basnight-Brown DM, Chartier CR, Buchanan EM, and Coles NA

Abstract

The COVID-19 pandemic (and its aftermath) highlights a critical need to communicate health information effectively to the global public. Given that subtle differences in information framing can have meaningful effects on behavior, behavioral science research highlights a pressing question: Is it more effective to frame COVID-19 health messages in terms of potential losses (e.g., "If you do not practice these steps, you can endanger yourself and others") or potential gains (e.g., "If you practice these steps, you can protect yourself and others")? Collecting data in 48 languages from 15,929 participants in 84 countries, we experimentally tested the effects of message framing on COVID-19-related judgments, intentions, and feelings. Loss- (vs. gain-) framed messages increased self-reported anxiety among participants cross-nationally with little-to-no impact on policy attitudes, behavioral intentions, or information seeking relevant to pandemic risks. These results were consistent across 84 countries, three variations of the message framing wording, and 560 data processing and analytic choices. Thus, results provide an empirical answer to a global communication question and highlight the emotional toll of loss-framed messages. Critically, this work demonstrates the importance of considering unintended affective consequences when evaluating nudge-style interventions., Competing Interests: Conflict of InterestThe authors declare no conflict of interest., (© The Society for Affective Science 2022.)

Published
2022
Full Text
View/download PDF

4. Author Correction: A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

Author

Wang K, Goldenberg A, Dorison CA, Miller JK, Uusberg A, Lerner JS, Gross JJ, Agesin BB, Bernardo M, Campos O, Eudave L, Grzech K, Ozery DH, Jackson EA, Garcia EOL, Drexler SM, Jurković AP, Rana K, Wilson JP, Antoniadi M, Desai K, Gialitaki Z, Kushnir E, Nadif K, Bravo ON, Nauman R, Oosterlinck M, Pantazi M, Pilecka N, Szabelska A, van Steenkiste IMM, Filip K, Bozdoc AI, Marcu GM, Agadullina E, Adamkovič M, Roczniewska M, Reyna C, Kassianos AP, Westerlund M, Ahlgren L, Pöntinen S, Adetula GA, Dursun P, Arinze AI, Arinze NC, Ogbonnaya CE, Ndukaihe ILG, Dalgar I, Akkas H, Macapagal PM, Lewis S, Metin-Orta I, Foroni F, Willis M, Santos AC, Mokady A, Reggev N, Kurfali MA, Vasilev MR, Nock NL, Parzuchowski M, Espinoza Barría MF, Vranka M, Kohlová MB, Ropovik I, Harutyunyan M, Wang C, Yao E, Becker M, Manunta E, Kaminski G, Boudesseul J, Marko D, Evans K, Lewis DMG, Findor A, Landry AT, Aruta JJB, Ortiz MS, Vally Z, Pronizius E, Voracek M, Lamm C, Grinberg M, Li R, Valentova JV, Mioni G, Cellini N, Chen SC, Zickfeld J, Moon K, Azab H, Levy N, Karababa A, Beaudry JL, Boucher L, Collins WM, Todsen AL, van Schie K, Vintr J, Bavolar J, Kaliska L, Križanić V, Samojlenko L, Pourafshari R, Geiger SJ, Beitner J, Warmelink L, Ross RM, Stephen ID, Hostler TJ, Azouaghe S, McCarthy R, Szala A, Grano C, Solorzano CS, Anjum G, Jimenez-Leal W, Bradford M, Pérez LC, Cruz Vásquez JE, Galindo-Caballero OJ, Vargas-Nieto JC, Kácha O, Arvanitis A, Xiao Q, Cárcamo R, Zorjan S, Tajchman Z, Vilares I, Pavlacic JM, Kunst JR, Tamnes CK, von Bastian CC, Atari M, Sharifian M, Hricova M, Kačmár P, Schrötter J, Rahal RM, Cohen N, FatahModares S, Zrimsek M, Zakharov I, Koehn MA, Esteban-Serna C, Calin-Jageman RJ, Krafnick AJ, Štrukelj E, Isager PM, Urban J, Silva JR, Martončik M, Očovaj SB, Šakan D, Kuzminska AO, Djordjevic JM, Almeida IAT, Ferreira A, Lazarevic LB, Manley H, Ricaurte DZ, Monteiro RP, Etabari Z, Musser E, Dunleavy D, Chou W, Godbersen H, Ruiz-Fernández S, Reeck C, Batres C, Kirgizova K, Muminov A, Azevedo F, Alvarez DS, Butt MM, Lee JM, Chen Z, Verbruggen F, Ziano I, Tümer M, Charyate ACA, Dubrov D, Tejada Rivera MDCMC, Aberson C, Pálfi B, Maldonado MA, Hubena B, Sacakli A, Ceary CD, Richard KL, Singer G, Perillo JT, Ballantyne T, Cyrus-Lai W, Fedotov M, Du H, Wielgus M, Pit IL, Hruška M, Sousa D, Aczel B, Hajdu N, Szaszi B, Adamus S, Barzykowski K, Micheli L, Schmidt ND, Zsido AN, Paruzel-Czachura M, Muda R, Bialek M, Kowal M, Sorokowska A, Misiak M, Mola D, Ortiz MV, Correa PS, Belaus A, Muchembled F, Ribeiro RR, Arriaga P, Oliveira R, Vaughn LA, Szwed P, Kossowska M, Czarnek G, Kielińska J, Antazo B, Betlehem R, Stieger S, Nilsonne G, Simonovic N, Taber J, Gourdon-Kanhukamwe A, Domurat A, Ihaya K, Yamada Y, Urooj A, Gill T, Čadek M, Bylinina L, Messerschmidt J, Kurfalı M, Adetula A, Baklanova E, Albayrak-Aydemir N, Kappes HB, Gjoneska B, House T, Jones MV, Berkessel JB, Chopik WJ, Çoksan S, Seehuus M, Khaoudi A, Bokkour A, El Arabi KA, Djamai I, Iyer A, Parashar N, Adiguzel A, Kocalar HE, Bundt C, Norton JO, Papadatou-Pastou M, De la Rosa-Gomez A, Ankushev V, Bogatyreva N, Grigoryev D, Ivanov A, Prusova I, Romanova M, Sarieva I, Terskova M, Hristova E, Kadreva VH, Janak A, Schei V, Sverdrup TE, Askelund AD, Pineda LMS, Krupić D, Levitan CA, Johannes N, Ouherrou N, Say N, Sinkolova S, Janjić K, Stojanovska M, Stojanovska D, Khosla M, Thomas AG, Kung FYH, Bijlstra G, Mosannenzadeh F, Balci BB, Reips UD, Baskin E, Ishkhanyan B, Czamanski-Cohen J, Dixson BJW, Moreau D, Sutherland CAM, Chuan-Peng H, Noone C, Flowe H, Anne M, Janssen SMJ, Topor M, Majeed NM, Kunisato Y, Yu K, Daches S, Hartanto A, Vdovic M, Anton-Boicuk L, Forbes PAG, Kamburidis J, Marinova E, Nedelcheva-Datsova M, Rachev NR, Stoyanova A, Schmidt K, Suchow JW, Koptjevskaja-Tamm M, Jernsäther T, Olofsson JK, Bialobrzeska O, Marszalek M, Tatachari S, Afhami R, Law W, Antfolk J, Žuro B, Van Doren N, Soto JA, Searston R, Miranda J, Damnjanović K, Yeung SK, Krupić D, Hoyer K, Jaeger B, Ren D, Pfuhl G, Klevjer K, Corral-Frías NS, Frias-Armenta M, Lucas MY, Torres AO, Toro M, Delgado LGJ, Vega D, Solas SÁ, Vilar R, Massoni S, Frizzo T, Bran A, Vaidis DC, Vieira L, Paris B, Capizzi M, Coelho GLH, Greenburgh A, Whitt CM, Tullett AM, Du X, Volz L, Bosma MJ, Karaarslan C, Sarıoğuz E, Allred TB, Korbmacher M, Colloff MF, Lima TJS, Ribeiro MFF, Verharen JPH, Karekla M, Karashiali C, Sunami N, Jaremka LM, Storage D, Habib S, Studzinska A, Hanel PHP, Holford DL, Sirota M, Wolfe K, Chiu F, Theodoropoulou A, Ahn ER, Lin Y, Westgate EC, Brohmer H, Hofer G, Dujols O, Vezirian K, Feldman G, Travaglino GA, Ahmed A, Li M, Bosch J, Torunsky N, Bai H, Manavalan M, Song X, Walczak RB, Zdybek P, Friedemann M, Rosa AD, Kozma L, Alves SG, Lins S, Pinto IR, Correia RC, Babinčák P, Banik G, Rojas-Berscia LM, Varella MAC, Uttley J, Beshears JE, Thommesen KK, Behzadnia B, Geniole SN, Silan MA, Maturan PLG, Vilsmeier JK, Tran US, Izquierdo SM, Mensink MC, Sorokowski P, Groyecka-Bernard A, Radtke T, Adoric VC, Carpentier J, Özdoğru AA, Joy-Gaba JA, Hedgebeth MV, Ishii T, Wichman AL, Röer JP, Ostermann T, Davis WE, Suter L, Papachristopoulos K, Zabel C, Onie S, Ebersole CR, Chartier CR, Mallik PR, Urry HL, Buchanan EM, Coles NA, Primbs MA, Basnight-Brown DM, IJzerman H, Forscher PS, and Moshontz H

Published
2022
Full Text
View/download PDF

5. Effects of mother's imitation on speech sounds in infants with Down syndrome.

Author

Fiani T, Izquierdo SM, and Jones EA

Subjects
Female, Humans, Imitative Behavior, Infant, Mothers, Speech, Down Syndrome, Phonetics
Abstract

Background: The Down syndrome behavioral phenotype includes delays in making speech sounds, production of more non-speech sounds than speech sounds, and contrasting strengths in social development. Within a behavior analytic framework, we conceptualize characteristics of the Down syndrome behavioral phenotype as creating a context for impairments in speech sound development that suggest interventions caregivers can use to improve speech sounds., Aim and Method: We examined one intervention, the effects of mother's contingent vocal imitation, on rate of speech and non-speech sound production in infants with Down syndrome using an ABAB design., Results: Mothers responded favorably to learning to imitate their infants' vocalizations and their contingent vocal imitation was associated with increases in infant speech sounds., Conclusions: The increases in infant speech sound suggest the promise of this approach and future research examining variations in contingent vocal imitation and additional outcomes., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
Full Text
View/download PDF

6. A multi-country test of brief reappraisal interventions on emotions during the COVID-19 pandemic.

Author

Wang K, Goldenberg A, Dorison CA, Miller JK, Uusberg A, Lerner JS, Gross JJ, Agesin BB, Bernardo M, Campos O, Eudave L, Grzech K, Ozery DH, Jackson EA, Garcia EOL, Drexler SM, Jurković AP, Rana K, Wilson JP, Antoniadi M, Desai K, Gialitaki Z, Kushnir E, Nadif K, Bravo ON, Nauman R, Oosterlinck M, Pantazi M, Pilecka N, Szabelska A, van Steenkiste IMM, Filip K, Bozdoc AI, Marcu GM, Agadullina E, Adamkovič M, Roczniewska M, Reyna C, Kassianos AP, Westerlund M, Ahlgren L, Pöntinen S, Adetula GA, Dursun P, Arinze AI, Arinze NC, Ogbonnaya CE, Ndukaihe ILG, Dalgar I, Akkas H, Macapagal PM, Lewis S, Metin-Orta I, Foroni F, Willis M, Santos AC, Mokady A, Reggev N, Kurfali MA, Vasilev MR, Nock NL, Parzuchowski M, Espinoza Barría MF, Vranka M, Kohlová MB, Ropovik I, Harutyunyan M, Wang C, Yao E, Becker M, Manunta E, Kaminski G, Boudesseu J, Marko D, Evans K, Lewis DMG, Findor A, Landry AT, Aruta JJB, Ortiz MS, Vally Z, Pronizius E, Voracek M, Lamm C, Grinberg M, Li R, Valentova JV, Mioni G, Cellini N, Chen SC, Zickfeld J, Moon K, Azab H, Levy N, Karababa A, Beaudry JL, Boucher L, Collins WM, Todsen AL, van Schie K, Vintr J, Bavolar J, Kaliska L, Križanić V, Samojlenko L, Pourafshari R, Geiger SJ, Beitner J, Warmelink L, Ross RM, Stephen ID, Hostler TJ, Azouaghe S, McCarthy R, Szala A, Grano C, Solorzano CS, Anjum G, Jimenez-Leal W, Bradford M, Pérez LC, Cruz Vásquez JE, Galindo-Caballero OJ, Vargas-Nieto JC, Kácha O, Arvanitis A, Xiao Q, Cárcamo R, Zorjan S, Tajchman Z, Vilares I, Pavlacic JM, Kunst JR, Tamnes CK, von Bastian CC, Atari M, Sharifian M, Hricova M, Kačmár P, Schrötter J, Rahal RM, Cohen N, FatahModares S, Zrimsek M, Zakharov I, Koehn MA, Esteban-Serna C, Calin-Jageman RJ, Krafnick AJ, Štrukelj E, Isager PM, Urban J, Silva JR, Martončik M, Očovaj SB, Šakan D, Kuzminska AO, Djordjevic JM, Almeida IAT, Ferreira A, Lazarevic LB, Manley H, Ricaurte DZ, Monteiro RP, Etabari Z, Musser E, Dunleavy D, Chou W, Godbersen H, Ruiz-Fernández S, Reeck C, Batres C, Kirgizova K, Muminov A, Azevedo F, Alvarez DS, Butt MM, Lee JM, Chen Z, Verbruggen F, Ziano I, Tümer M, Charyate ACA, Dubrov D, Tejada Rivera MDCMC, Aberson C, Pálfi B, Maldonado MA, Hubena B, Sacakli A, Ceary CD, Richard KL, Singer G, Perillo JT, Ballantyne T, Cyrus-Lai W, Fedotov M, Du H, Wielgus M, Pit IL, Hruška M, Sousa D, Aczel B, Hajdu N, Szaszi B, Adamus S, Barzykowski K, Micheli L, Schmidt ND, Zsido AN, Paruzel-Czachura M, Muda R, Bialek M, Kowal M, Sorokowska A, Misiak M, Mola D, Ortiz MV, Correa PS, Belaus A, Muchembled F, Ribeiro RR, Arriaga P, Oliveira R, Vaughn LA, Szwed P, Kossowska M, Czarnek G, Kielińska J, Antazo B, Betlehem R, Stieger S, Nilsonne G, Simonovic N, Taber J, Gourdon-Kanhukamwe A, Domurat A, Ihaya K, Yamada Y, Urooj A, Gill T, Čadek M, Bylinina L, Messerschmidt J, Kurfalı M, Adetula A, Baklanova E, Albayrak-Aydemir N, Kappes HB, Gjoneska B, House T, Jones MV, Berkessel JB, Chopik WJ, Çoksan S, Seehuus M, Khaoudi A, Bokkour A, El Arabi KA, Djamai I, Iyer A, Parashar N, Adiguzel A, Kocalar HE, Bundt C, Norton JO, Papadatou-Pastou M, De la Rosa-Gomez A, Ankushev V, Bogatyreva N, Grigoryev D, Ivanov A, Prusova I, Romanova M, Sarieva I, Terskova M, Hristova E, Kadreva VH, Janak A, Schei V, Sverdrup TE, Askelund AD, Pineda LMS, Krupić D, Levitan CA, Johannes N, Ouherrou N, Say N, Sinkolova S, Janjić K, Stojanovska M, Stojanovska D, Khosla M, Thomas AG, Kung FYH, Bijlstra G, Mosannenzadeh F, Balci BB, Reips UD, Baskin E, Ishkhanyan B, Czamanski-Cohen J, Dixson BJW, Moreau D, Sutherland CAM, Chuan-Peng H, Noone C, Flowe H, Anne M, Janssen SMJ, Topor M, Majeed NM, Kunisato Y, Yu K, Daches S, Hartanto A, Vdovic M, Anton-Boicuk L, Forbes PAG, Kamburidis J, Marinova E, Nedelcheva-Datsova M, Rachev NR, Stoyanova A, Schmidt K, Suchow JW, Koptjevskaja-Tamm M, Jernsäther T, Olofsson JK, Bialobrzeska O, Marszalek M, Tatachari S, Afhami R, Law W, Antfolk J, Žuro B, Van Doren N, Soto JA, Searston R, Miranda J, Damnjanović K, Yeung SK, Krupić D, Hoyer K, Jaeger B, Ren D, Pfuhl G, Klevjer K, Corral-Frías NS, Frias-Armenta M, Lucas MY, Torres AO, Toro M, Delgado LGJ, Vega D, Solas SÁ, Vilar R, Massoni S, Frizzo T, Bran A, Vaidis DC, Vieira L, Paris B, Capizzi M, Coelho GLH, Greenburgh A, Whitt CM, Tullett AM, Du X, Volz L, Bosma MJ, Karaarslan C, Sarıoğuz E, Allred TB, Korbmacher M, Colloff MF, Lima TJS, Ribeiro MFF, Verharen JPH, Karekla M, Karashiali C, Sunami N, Jaremka LM, Storage D, Habib S, Studzinska A, Hanel PHP, Holford DL, Sirota M, Wolfe K, Chiu F, Theodoropoulou A, Ahn ER, Lin Y, Westgate EC, Brohmer H, Hofer G, Dujols O, Vezirian K, Feldman G, Travaglino GA, Ahmed A, Li M, Bosch J, Torunsky N, Bai H, Manavalan M, Song X, Walczak RB, Zdybek P, Friedemann M, Rosa AD, Kozma L, Alves SG, Lins S, Pinto IR, Correia RC, Babinčák P, Banik G, Rojas-Berscia LM, Varella MAC, Uttley J, Beshears JE, Thommesen KK, Behzadnia B, Geniole SN, Silan MA, Maturan PLG, Vilsmeier JK, Tran US, Izquierdo SM, Mensink MC, Sorokowski P, Groyecka-Bernard A, Radtke T, Adoric VC, Carpentier J, Özdoğru AA, Joy-Gaba JA, Hedgebeth MV, Ishii T, Wichman AL, Röer JP, Ostermann T, Davis WE, Suter L, Papachristopoulos K, Zabel C, Onie S, Ebersole CR, Chartier CR, Mallik PR, Urry HL, Buchanan EM, Coles NA, Primbs MA, Basnight-Brown DM, IJzerman H, Forscher PS, and Moshontz H

Subjects
Adult, Female, Humans, Male, COVID-19 psychology, Emotional Regulation, Emotions
Abstract

The COVID-19 pandemic has increased negative emotions and decreased positive emotions globally. Left unchecked, these emotional changes might have a wide array of adverse impacts. To reduce negative emotions and increase positive emotions, we tested the effectiveness of reappraisal, an emotion-regulation strategy that modifies how one thinks about a situation. Participants from 87 countries and regions (n = 21,644) were randomly assigned to one of two brief reappraisal interventions (reconstrual or repurposing) or one of two control conditions (active or passive). Results revealed that both reappraisal interventions (vesus both control conditions) consistently reduced negative emotions and increased positive emotions across different measures. Reconstrual and repurposing interventions had similar effects. Importantly, planned exploratory analyses indicated that reappraisal interventions did not reduce intentions to practice preventive health behaviours. The findings demonstrate the viability of creating scalable, low-cost interventions for use around the world. PROTOCOL REGISTRATION: The stage 1 protocol for this Registered Report was accepted in principle on 12 May 2020. The protocol, as accepted by the journal, can be found at https://doi.org/10.6084/m9.figshare.c.4878591.v1., (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)

Published
2021
Full Text
View/download PDF

7. Assessing kinetic and epitopic diversity across orthogonal monoclonal antibody generation platforms.

Author

Abdiche YN, Harriman R, Deng X, Yeung YA, Miles A, Morishige W, Boustany L, Zhu L, Izquierdo SM, and Harriman W

Subjects
Animals, Binding Sites, Antibody, Female, Humans, Kinetics, Mice, Species Specificity, Antibodies, Monoclonal immunology, Antibody Specificity immunology, Avian Proteins immunology, Chickens immunology, Epitopes immunology
Abstract

The ability of monoclonal antibodies (mAbs) to target specific antigens with high precision has led to an increasing demand to generate them for therapeutic use in many disease areas. Historically, the discovery of therapeutic mAbs has relied upon the immunization of mammals and various in vitro display technologies. While the routine immunization of rodents yields clones that are stable in serum and have been selected against vast arrays of endogenous, non-target self-antigens, it is often difficult to obtain species cross-reactive mAbs owing to the generally high sequence similarity shared across human antigens and their mammalian orthologs. In vitro display technologies bypass this limitation, but lack an in vivo screening mechanism, and thus may potentially generate mAbs with undesirable binding specificity and stability issues. Chicken immunization is emerging as an attractive mAb discovery method because it combines the benefits of both in vivo and in vitro display methods. Since chickens are phylogenetically separated from mammals, their proteins share less sequence homology with those of humans, so human proteins are often immunogenic and can readily elicit rodent cross-reactive clones, which are necessary for in vivo proof of mechanism studies. Here, we compare the binding characteristics of mAbs isolated from chicken immunization, mouse immunization, and phage display of human antibody libraries. Our results show that chicken-derived mAbs not only recapitulate the kinetic diversity of mAbs sourced from other methods, but appear to offer an expanded repertoire of epitopes. Further, chicken-derived mAbs can bind their native serum antigen with very high affinity, highlighting their therapeutic potential.

Published
2016
Full Text
View/download PDF

8. Immunoglobulin knockout chickens via efficient homologous recombination in primordial germ cells.

Author

Schusser B, Collarini EJ, Yi H, Izquierdo SM, Fesler J, Pedersen D, Klasing KC, Kaspers B, Harriman WD, van de Lavoir MC, Etches RJ, and Leighton PA

Subjects
Animals, B-Lymphocytes metabolism, Blotting, Southern, Chickens immunology, DNA Methylation, DNA Primers genetics, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Genotype, Germ Cells metabolism, Immunohistochemistry, B-Lymphocytes cytology, Chickens genetics, Gene Knockout Techniques methods, Genetic Engineering methods, Germ Cells chemistry, Immunoglobulin Heavy Chains genetics
Abstract

Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their functions. Although gene targeting has been used extensively to modify the genomes of mammals, fish, and amphibians, a targeting technology has not been available for the avian genome. Many of the principles of humoral immunity were discovered in chickens, yet the lack of gene targeting technologies in birds has limited biomedical research using this species. Here we describe targeting the joining (J) gene segment of the chicken Ig heavy chain gene by homologous recombination in primordial germ cells to establish fully transgenic chickens carrying the knockout. In homozygous knockouts, Ig heavy chain production is eliminated, and no antibody response is elicited on immunization. Migration of B-lineage precursors into the bursa of Fabricius is unaffected, whereas development into mature B cells and migration from the bursa are blocked in the mutants. Other cell types in the immune system appear normal. Chickens lacking the peripheral B-cell population will provide a unique experimental model to study avian immune responses to infectious disease. More generally, gene targeting in avian primordial germ cells will foster advances in diverse fields of biomedical research such as virology, stem cells, and developmental biology, and provide unique approaches in biotechnology, particularly in the field of antibody discovery.

Published
2013
Full Text
View/download PDF

9. Harnessing gene conversion in chicken B cells to create a human antibody sequence repertoire.

Author

Schusser B, Yi H, Collarini EJ, Izquierdo SM, Harriman WD, Etches RJ, and Leighton PA

Subjects
Amino Acid Sequence, Animals, Animals, Genetically Modified, Antibodies chemistry, Base Sequence, Blotting, Western, Cell Line, DNA Primers, Flow Cytometry, Humans, Molecular Sequence Data, Sequence Homology, Amino Acid, Antibodies genetics, B-Lymphocytes metabolism, Chickens genetics, Gene Conversion
Abstract

Transgenic chickens expressing human sequence antibodies would be a powerful tool to access human targets and epitopes that have been intractable in mammalian hosts because of tolerance to conserved proteins. To foster the development of the chicken platform, it is beneficial to validate transgene constructs using a rapid, cell culture-based method prior to generating fully transgenic birds. We describe a method for the expression of human immunoglobulin variable regions in the chicken DT40 B cell line and the further diversification of these genes by gene conversion. Chicken VL and VH loci were knocked out in DT40 cells and replaced with human VK and VH genes. To achieve gene conversion of human genes in chicken B cells, synthetic human pseudogene arrays were inserted upstream of the functional human VK and VH regions. Proper expression of chimeric IgM comprised of human variable regions and chicken constant regions is shown. Most importantly, sequencing of DT40 genetic variants confirmed that the human pseudogene arrays contributed to the generation of diversity through gene conversion at both the Igl and Igh loci. These data show that engineered pseudogene arrays produce a diverse pool of human antibody sequences in chicken B cells, and suggest that these constructs will express a functional repertoire of chimeric antibodies in transgenic chickens.

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results