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2. DE-PASS Best Evidence Statement (BESt): A Systematic Review and Meta-analysis on the Effectiveness of Trials on Device-Measured Physical Activity and Sedentary Behaviour and Their Determinants in Children Aged 5–12 Years: Determinants of Device-Measured Physical Activity and Sedentary Behaviour in Children

Author

Khudair, Mohammed, Marcuzzi, Anna, Tempest, Gavin Daniel, Ng, Kwok, Peric, Ratko, Bartoš, František, Maier, Maximilian, Brandes, Mirko, Carlin, Angela, Ciaccioni, Simone, Cortis, Cristina, Corvino, Chiara, di Credico, Andrea, Drid, Patrik, Gallè, Francesca, Izzicupo, Pascal, Jahre, Henriette, Kolovelonis, Athanasios, Kongsvold, Atle, Kouidi, Evangelia, Mork, Paul Jarle, Palumbo, Federico, Rumbold, Penny Louise Sheena, Sandu, Petru, Stavnsbo, Mette, Syrmpas, Ioannis, Vilela, Sofia, Woods, Catherine, Wunsch, Kathrin, Capranica, Laura, MacDonncha, Ciaran, and Ling, Fiona Chun Man

Published
2024
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3. DE-PASS best evidence statement (BESt): determinants of adolescents’ device-based physical activity and sedentary behaviour in settings: a systematic review and meta-analysis

Author

Kolovelonis, Athanasios, Syrmpas, Ioannis, Marcuzzi, Anna, Khudair, Mohammed, Ng, Kwok, Tempest, Gavin Daniel, Peric, Ratko, Bartoš, František, Maier, Maximilian, Brandes, Mirko, Carlin, Angela, Ciaccioni, Simone, Cortis, Cristina, Corvino, Chiara, Di Credico, Andrea, Drid, Patrik, Gallè, Francesca, Izzicupo, Pascal, Jahre, Henriette, Kongsvold, Atle, Kouidi, Evangelia, Mork, Paul Jarle, Palumbo, Federico, Rumbold, Penny Louise Sheena, Sandu, Petru, Stavnsbo, Mette, Vilela, Sofia, Woods, Catherine, Wunsch, Kathrin, Capranica, Laura, MacDonncha, Ciaran, and Ling, Fiona Chun Man

Published
2024
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5. Gut microbiota and physical activity level: characterization from sedentary to soccer players.

Author

Petri, Cristian, Mascherini, Gabriele, Izzicupo, Pascal, Rosati, Diletta, Cerboneschi, Matteo, Smeazzetto, Serena, and Suarez Arrones, Luis

Abstract

Evidence of the relationship between physical activity and gut microbiota composition is steadily increasing. The purpose of the study is to compare the gut microbiota composition of a group of elite male soccer players with a group of subjects with different physical activity levels. Cross-sectional studies were performed on 91 healthy young males, in detail: 17 elite soccer players (23.7 ± 4.2 yrs, BMI 23.2 ± 1.2 kg/m²); 14 with high levels of physical training (24.5 ± 5.6 yrs, BMI 22.7 ± 0.8 kg/m²); 23 with moderate levels of physical training (29.3 ± 3.9 yrs, BMI 22.5 ± 0.8 kg/m2); and 37 healthy men without exercise habits (28.1 ± 5.9 yrs, BMI 22.4 ± 1.0 kg/m²). Relative microbiota composition was determined by analyzing DNA extracted from stool samples. The quality and quantity of extracted DNA were assessed using a Qubit Fluorometer. Differences between subjects' populations were analyzed using a one-way ANOVA, and Bonferroni's post-hoc test was employed to identify localized effects. Elite soccer players and subjects with high physical activity levels showed a significantly higher prevalence of the nine microbiota populations analyzed than subjects with moderate physical training or who were sedentary. No differences were found in the Firmicutes to Bacteroidetes ratio among the different study populations. This study reports the gut microbiota parameters of elite footballers for the first time. In addition, it brings new insights into the effects of different levels of physical activity on the composition of the gut microbiota. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Correction to: Biological determinants of physical activity across the life course: a “Determinants of Diet and Physical Activity” (DEDIPAC) umbrella systematic literature review

Author

Aleksovska, Katina, Puggina, Anna, Giraldi, Luca, Buck, Christoph, Burns, Con, Cardon, Greet, Carlin, Angela, Chantal, Simon, Ciarapica, Donatella, Colotto, Marco, Condello, Giancarlo, Coppinger, Tara, Cortis, Cristina, D’Haese, Sara, De Craemer, Marieke, Di Blasio, Andrea, Hansen, Sylvia, Iacoviello, Licia, Issartel, Johann, Izzicupo, Pascal, Jaeschke, Lina, Kanning, Martina, Kennedy, Aileen, Ling, Fiona, Luzak, Agnes, Napolitano, Giorgio, Nazare, Julie-Anne, Perchoux, Camille, Pischon, Tobias, Polito, Angela, Sannella, Alessandra, Schulz, Holger, Sohun, Rhoda, Steinbrecher, Astrid, Schlicht, Wolfgang, Ricciardi, Walter, MacDonncha, Ciaran, Capranica, Laura, and Boccia, Stefania

Published
2020
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7. Effects of acupuncture and Nordic walking practice, and their interaction, on bodily fluids distribution of breast cancer survivors

Author

Di Blasio, A., Rinaldi, M., Morano, T., Izzicupo, P., Dell'Aquila, S., Grossi, S., Russo, L., Bergamin, M., Gobbo, S., Viscioni, G., Cruz-Diaz, D., Di Giandomenico, F., and Cianchetti, E.

Subjects
Public Health, Environmental and Occupational Health, Biophysics, Physical Therapy, Sports Therapy and Rehabilitation
Published
2023
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8. Biological determinants of physical activity across the life course: a “Determinants of Diet and Physical Activity” (DEDIPAC) umbrella systematic literature review

Author

Aleksovska, Katina, Puggina, Anna, Giraldi, Luca, Buck, Christoph, Burns, Con, Cardon, Greet, Carlin, Angela, Chantal, Simon, Ciarapica, Donatella, Colotto, Marco, Condello, Giancarlo, Coppinger, Tara, Cortis, Cristina, D’Haese, Sara, De Craemer, Marieke, Di Blasio, Andrea, Hansen, Sylvia, Iacoviello, Licia, Issartel, Johann, Izzicupo, Pascal, Jaeschke, Lina, Kanning, Martina, Kennedy, Aileen, Ling, Fiona, Luzak, Agnes, Napolitano, Giorgio, Nazare, Julie-Anne, Perchoux, Camille, Pischon, Tobias, Polito, Angela, Sannella, Alessandra, Schulz, Holger, Sohun, Rhoda, Steinbrecher, Astrid, Schlicht, Wolfgang, Ricciardi, Walter, MacDonncha, Ciaran, Capranica, Laura, and Boccia, Stefania

Published
2019
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11. New bioelectrical impedance vector references and phase angle centile curves in 4,367 adults: The need for an urgent update after 30 years.

Author

Campa, Francesco, Coratella, Giuseppe, Cerullo, Giuseppe, Stagi, Silvia, Paoli, Samuele, Marini, Sofia, Grigoletto, Alessia, Moroni, Alessia, Petri, Cristian, Andreoli, Angela, Ceolin, Chiara, Degan, Raffaella, Izzicupo, Pascal, Sergi, Giuseppe, Mascherini, Gabriele, Micheletti Cremasco, Margherita, Marini, Elisabetta, Toselli, Stefania, Moro, Tatiana, and Paoli, Antonio

Abstract

The bioelectrical impedance vector analysis (BIVA) represents a qualitative analysis of body composition. The vector, defined by resistance (R) and reactance (Xc) standardized by stature, can be evaluated compared to the 50%,75%, and 95% tolerance ellipses representative of the reference populations. The tolerance ellipses for healthy adults have been provided in 1995 and were developed by mixing underage, adult, and elderly subjects, possibly misrepresenting the actual adult population. The current multicentric, cross-sectional study aimed to provide new tolerance ellipses specific for the general adult population and as a secondary aim to present centile curves for the bioelectrical phase angle. R, Xc, and phase angle were measured in 2137 and 2230 males and females using phase-sensitive foot-to-hand analyzers at 50 kHz. A minimum of 35 subjects were included for each sex and age category from 18 to 65 years. The new mean vectors showed a leftward shift on the R–Xc graph with respect to the former reference values (males: F = 75.3; p < 0.001; females: F = 36.6, p < 0.001). The results provided new 3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th, and 97th percentile curves for phase angle, identifying time point phases of decrement (males: −0.03° per year at 33.0–51.0 years and −0.05° per year after 51 years; females: −0.03° per year from 37.2 to 57.9 years). Compared to the original references, the new data are characterized by a different distribution within the R-Xc graph with a higher phase angle. Thirty years after the BIVA invention, the current study presents new tolerance ellipses and phase angle reference values for the adult population. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Normative values and a new predicted model of exercise blood pressure in young athletes.

Author

Mascherini, Gabriele, Galanti, Giorgio, Stefani, Laura, and Izzicupo, Pascal

Abstract

Objectives: Assessing the systolic and diastolic blood pressure during acute physical exertion can allow the discovery of many cardiovascular diseases even at a young age. However, this response depends on the age, sex of the subject, and the modality of the graded exercise test. This study aims to provide sex-and age-related normative values of peak and recovery blood pressure performance and to develop a predicted model of systolic and diastolic blood pressure peak in young athletes.Design: Retrospective-study.Methods: We analyzed 8224 young athletes (5516 males and 2708 females) aged between 8 and 18. Anthropometric and blood pressure parameters related to the effort are reported. Then, according to sex, graded exercise test modality, and age were calculated 1) the fifth, tenth, fiftieth, ninetieth, and ninety-fifth percentiles for the systolic and diastolic blood pressure at peak and after 1 min of recovery and 2) predictive equations of systolic and diastolic blood pressure at the peak.Results: Younger athletes show lower peak blood pressure values, gradually increasing as they age. Males showed higher peak systolic blood pressure values starting at 12-13 years on the cycle ergometer and 10-11 years on the treadmill, while there was no difference in peak diastolic blood pressure values.Conclusions: Sex, age, and the specificity of the movement performed must be considered in assessing the blood pressure response in the young population. In addition, providing reference values and predictive equations of blood pressure response to acute physical exertion may allow for a better functional assessment of young athletes. [ABSTRACT FROM AUTHOR]

Published
2023
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15. Betaine Treatment Prevents TNF-α-Mediated Muscle Atrophy by Restoring Total Protein Synthesis Rate and Morphology in Cultured Myotubes

Author

Di Credico, Andrea, Gaggi, Giulia, Izzicupo, Pascal, Vitucci, Daniela, Buono, Pasqualina, Di Baldassarre, Angela, and Ghinassi, Barbara

Abstract

Skeletal muscle atrophy is represented by a dramatic decrease in muscle mass, and it is related to a lower life expectancy. Among the different causes, chronic inflammation and cancer promote protein loss through the effect of inflammatory cytokines, leading to muscle shrinkage. Thus, the availability of safe methods to counteract inflammation-derived atrophy is of high interest. Betaine is a methyl derivate of glycine and it is an important methyl group donor in transmethylation. Recently, some studies found that betaine could promote muscle growth, and it is also involved in anti-inflammatory mechanisms. Our hypothesis was that betaine would be able to prevent tumor necrosis factor-α (TNF-α)-mediated muscle atrophy in vitro. We treated differentiated C2C12 myotubes for 72 hr with either TNF-α, betaine, or a combination of them. After the treatment, we analyzed total protein synthesis, gene expression, and myotube morphology. Betaine treatment blunted the decrease in muscle protein synthesis rate exerted by TNF-α, and upregulated Mhy1 gene expression in both control and myotube treated with TNF-α. In addition, morphological analysis revealed that myotubes treated with both betaine and TNF-α did not show morphological features of TNF-α-mediated atrophy. We demonstrated that in vitro betaine supplementation counteracts the muscle atrophy led by inflammatory cytokines.

Published
2023
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18. Correction to: Biological determinants of physical activity across the life course: a 'Determinants of Diet and Physical Activity' (DEDIPAC) umbrella systematic literature review (Sports Medicine - Open, (2019), 5, 1, (2), 10.1186/s40798-018-0173-9)

Author

Aleksovska, K., Puggina, A., Giraldi, L., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Colotto, M., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Ling, F., Luzak, A., Napolitano, G., Nazare, J. -A., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., Macdonncha, C., Capranica, L., and Boccia, S.

Published
2020

19. Biological determinants of physical activity across the life course: a 'Determinants of Diet and Physical Activity' (DEDIPAC) umbrella systematic literature review

Author

Aleksovska, K., Puggina, A., Giraldi, L., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Colotto, M., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Ling, F., Luzak, A., Napolitano, G., Nazare, J.A., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

BACKGROUND: Despite the large number of studies and reviews available, the evidence regarding the biological determinants of physical activity (PA) is inconclusive. In this umbrella review, we summarized the current evidence on the biological determinants of PA across the life course, by pooling the results of the available systematic literature reviews (SLRs) and meta-analyses (MAs). METHODS: We conducted an online search on MEDLINE, ISI Web of Science, Scopus, and SPORTDiscus databases up to January 2018. SLRs and MAs of observational studies that investigated the association between biological determinants of PA and having PA as outcome were considered eligible. The extracted data were assessed based on the importance of the determinants, the strength of evidence, and the methodological quality. RESULTS: We identified 19 reviews of which most were of moderate methodological quality. Determinants that were studied most frequently among all ages and demonstrated evidence suggesting a positive association to PA were younger age, being male, higher health status, and higher physical fitness levels. Among adults, normal birth weight was found to be positively associated to PA with convincing strength of evidence, while findings among adolescents were inconsistent and with limited strength of evidence. CONCLUSIONS: Different social or behavioral factors may contribute to the decrease of PA with age and among females versus males, and creating programmes targeted at diverse ages, female population, and adults with abnormal birth weight is recommended. Future studies should use prospective study designs, standardized definitions of PA, and objective measurement methods of PA assessment.

Published
2019

20. Policy determinants of physical activity across the life course: a 'DEDIPAC' umbrella systematic literature review

Author

Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Chun Man Ling, F., Luzak, A., Napolitano, G., Nazare, J.A., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

BACKGROUND: Despite the large number of studies and reviews available, the evidence regarding the policy determinants of physical activity (PA) is inconclusive. This umbrella systematic literature review (SLR) summarizes the current evidence on the policy determinants of PA across the life course, by pooling the results of the available SLRs and meta-analyses (MAs). METHODS: A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus and SPORTDiscus databases up to April 2016. SLRs and MAs of observational studies investigating the association between policy determinants of PA and having PA as outcome were considered eligible. The extracted data were assessed based on the importance of the determinants, the strength of evidence and the methodological quality. RESULTS: Fourteen reviews on 27 policy determinants of PA were eligible for this umbrella SLR. The majority of the reviews were of moderate quality. Among children, a clear association between time spent outdoors and PA emerged. Among adults, working hours were negatively associated with PA, though evidence was limited. At the population level, community- and street-scale urban design and land use policies were found to positively support PA levels, but levels of evidences were low. CONCLUSIONS: With this umbrella SLR the policy determinants of PA at individual-level and Population-level have been summarized and assessed. None of the investigated policy determinants had a convincing level of evidence, and very few had a probable level of evidence. Further research is needed, preferably by using prospective study designs, standardized definitions of PA and objective measurement of PA.

Published
2018

21. Socio-economic determinants of physical activity across the life course: a 'DEterminants of DIet and Physical ACtivity' (DEDIPAC) umbrella literature review

Author

O'Donoghue, G., Kennedy, A., Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Ciarapica, D., Colotto, M., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Ling, F., Luzak, A., Napolitano, G., Nazare, J.A., Perchoux, C., Pesce, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Simon, C., Sohun, R., Steinbrecher, A., Schlicht, W., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

BACKGROUND: To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course. METHODS: Medline, Embase, ISI Web of Science, Scopus and SPORTDiscus were searched for systematic literature reviews and meta-analyses of observational studies investigating the association between socioeconomic determinants of PA and PA itself (from January 2004 to September 2017). Data extraction evaluated the importance of determinants, strength of evidence, and methodological quality of the selected papers. The full protocol is available from PROSPERO (PROSPERO2014:CRD42015010616). RESULTS: Nineteen reviews were included. Moderate methodological quality emerged. For adults, convincing evidence supports a relationship between PA and socioeconomic status (SES), especially in relation to leisure time (positive relationship) and occupational PA (negative relationship). Conversely, no association between PA and SES or parental SES was found for pre-school, school-aged children and adolescents. CONCLUSIONS: Available evidence on the socioeconomic determinants of PA behaviour across the life course is probable (shows fairly consistent associations) at best. While some evidence is available for adults, less was available for youth. This is mainly due to a limited quantity of primary studies, weak research designs and lack of accuracy in the PA and SES assessment methods employed. Further PA domain specific studies using longitudinal design and clear measures of SES and PA assessment are required.

Published
2018

22. Socio-cultural determinants of physical activity across the life course: a 'Determinants of Diet and Physical Activity' (DEDIPAC) umbrella systematic literature review

Author

Jaeschke, L., Steinbrecher, A., Luzak, A., Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Condello, G., Coppinger, T., Cortis, C., De Craemer, M., D'Haese, S., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Kanning, M., Kennedy, A., Ling, F.C.M., Napolitano, G., Nazare, J.A., Perchoux, C., Polito, A., Ricciardi, W., Sannella, A., Schlicht, W., Sohun, R., MacDonncha, C., Boccia, S., Capranica, L., Schulz, H., and Pischon, T.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

OBJECTIVE: Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and economic burden caused by low activity. Studies suggest that socio-cultural factors may affect PA, but systematic overviews of findings across the life course are scarce. This umbrella systematic literature review (SLR) summarizes and evaluates available evidence on socio-cultural determinants of PA in children, adolescents, and adults. METHODS: This manuscript was drafted following the recommendations of the 'Preferred Reporting Items for Systematic reviews and Meta-Analyses' (PRISMA) checklist. The MEDLINE, Web of Science, Scopus, and SPORTDiscus databases were searched for SLRs and meta-analyses (MAs) on observational studies published in English that assessed PA determinants between January 2004 and April 2016. The methodological quality was assessed and relevant information on socio-cultural determinants and any associations with PA was extracted. The available evidence was evaluated based on the importance of potential determinants and the strength of the evidence. RESULTS: Twenty SLRs and three MAs encompassing 657 eligible primary studies investigated potential socio-cultural PA determinants, with predominantly moderate methodological quality. Twenty-nine potential PA determinants were identified that were primarily assessed in children and adolescents and investigated the micro-environmental home/household level. We found probable evidence that receiving encouragement from significant others and having a companion for PA were associated with higher PA in children and adolescents, and that parental marital status (living with partner) and experiencing parental modeling were not associated with PA in children. Evidence for the other potential determinants was limited, suggestive, or non-conclusive. In adults, quantitative and conclusive data were scarce. CONCLUSIONS: A substantial number of SLRs and MAs investigating potential socio-cultural determinants of PA were identified. Our data suggest that receiving social support from significant others may increase PA levels in children and adolescents, whereas parental marital status is not a determinant in children. Evidence for other potential determinants was limited. This was mainly due to inconsistencies in results on potential socio-cultural determinants of PA across reviews and studies. TRIAL REGISTRATIONS: This umbrella SLR was recorded on PROSPERO (Record ID: CRD42015010616).

Published
2017

23. The role of the LISTANet Consortium in the European DEDIPAC-KH project

Author

Condello, G., Migliaccio, S., Pesce, C., Tessitore, A., Forte, R., Leone, L., Masci, I., Ricciardi, W., Boccia, S., Puggina, A., Colotto, M., Fedeli, G., Lenzi, A., Donini, L. M., Napolitano, G., Di Baldassarre, A., Di Blasio, A., Izzicupo, P., Palma, A., Bianco, A., Porro, Nicola, Castellani, Loriana, Cortis, Cristina, Sannella, Alessandra, Macdonncha, C., and Capranica, L.

Subjects
LISTANet, Consortium in the European, physical activity (PA), and sedentary behaviours, Diet, LISTANet, Consortium in the European, and sedentary behaviours, physical activity (PA), Diet
Abstract

Aim:To improve understanding of the determinants of dietary, physical activity (PA), and sedentary behaviours, the European multi-disciplinary consortium on “Determinants of Diet and Physical Activity Knowledge Hub” (DEDIPAC-KH) includes 46 consortia and organisations supported by joint programming grants from 12 countries across Europe (Lakerveld et al., 2014). Six Italian Universities (e.g., Cassino, Chieti-Pescara, Palermo, Roma Foro Italico, Roma Sapienza, and UCSC) participating in the LISTANet consortium supported by MIUR (B84G14000040008) contributed to the Thematic Area2 “Determinants of dietary, PA, and sedentary behaviours across the life course and in vulnerable groups”. In particular, the coordinator of LISTANet Prof Capranica and Prof. MacDonncha from the Irish Physical Activity and Health Consortium act as Work Package (WP) Leaders of PA determinants (WP2.2). Methods: A mix of methods has been used in identifying PA determinants by developing PA taxonomy and a European framework (EU-PAD), seven umbrella systematic literature reviews (e.g., behavioural, biological, economic, physical, policy, psychological, and socio-cultural), and identifying ongoing/recently completed European-funded projects and data sets for secondary data analyses. Results: LISTANet participated in DEDIPAC-KH meetings/seminars/courses/conferences, and organized two workshops dedicated to the EU-PAD framework and umbrella SLRs. Outcomes included internal reports, presentations to international conferences, and scientific papers submitted for publications. Conclusions: The DEDIPAC-KH project represents an excellent start in setting up a complex, cross-country, organisational structure to: 1) guide a European strategic plan for novel and multi-disciplinary research addressing the complexity of determinants of PA behaviours across the life course; and 2) identify key aspects for potential strategies and intervention programmes to implement multi-sectoral European policies in PA. Finally, the cumulated experience of LISTANet could be valuable to fully exploit effective research and actions to increase PA levels of Italian citizens., Italian Journal of Anatomy and Embryology, Vol. 121, No. 1 (Supplement) 2016

Published
2017
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24. Psychological determinants of physical activity across the life course: a 'determinants of diet and physical activity' (DEDIPAC) umbrella systematic literature review

Author

Cortis, C., Puggina, A., Pesce, C., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Simon, C., Ciarapica, D., Condello, G., Coppinger, T., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Ling, F.C.M., Luzak, A., Napolitano, G., Nazare, J.A., O'Donoghue, G., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., Castellani, L., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Low levels of physical activity (PA) are reported to contribute to the occurrence of non-communicable diseases over the life course. Although psychological factors have been identified as an important category concerning PA behavior, knowledge on psychological determinants of PA is still inconclusive. Therefore, the aim of this umbrella systematic literature review (SLR) was to summarize and synthesize the scientific evidence on psychological determinants of PA behavior across the life course. A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus, and SPORTDiscus databases. The search was limited to studies published in English from January 2004 to April 2016. SLRs and meta-analyses (MAs) of observational studies investigating the association of psychological variables and PA were considered eligible. Extracted data were evaluated based on importance of determinants, strength of evidence, and methodological quality. The full protocol is available from PROSPERO (Record ID: CRD42015010616). Twenty reviews (14 SLRs and 6 MAs), mostly of moderate methodological quality, were found eligible. Convincing evidence was found for self-efficacy (positive association with PA) in children and adolescents, and stress (negative association with PA) regardless of age. Most of the evidence revealing an association between psychological determinants and PA is probable and limited, mainly due to differences in the definition of PA and of psychological determinants across reviews. Thus, scholars are urged to reach a consensus on clear definitions of relevant psychological determinants of PA, subsuming cultural biases and allowing the possibility to obtain clear interpretations and generalizability of findings. Finally, most psychological determinants should be considered within a larger framework of other multi-level determinants that may interact or mediate some of the effects.

Published
2017

25. A life course examination of the physical environmental determinants of physical activity behaviour: A 'Determinants of Diet and Physical Activity' (DEDIPAC) umbrella systematic literature review

Author

Carlin, A., Perchoux, C., Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Chantal, S., Ciarapica, D., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, A., Lakerveld, J., Chun Man Ling, F., Luzak, A., Napolitano, G., Nazare, J.A., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

Background: Participation in regular physical activity is associated with a multitude of health benefits across the life course. However, many people fail to meet PA recommendations. Despite a plethora of studies, the evidence regarding the environmental (physical) determinants of physical activity remains inconclusive. Objective: To identify the physical environmental determinants that influence PA across the life course. Methods: An online systematic literature search was conducted using MEDLINE, ISI Web of Science, Scopus and SPORTDiscus. The search was limited to studies published in English (January 2004 to April 2016). Only systematic literature reviews (SLRs) and meta-analyses (MAs) of observational studies, that investigated the association between physical determinants and physical activity outcomes, were eligible for inclusion. The extracted data were assessed on the importance of determinants, strength of evidence and methodological quality. Results: The literature search identified 28 SLRs and 3 MAs on 67 physical environmental characteristics potentially related to physical activity that were eligible for inclusion. Among preschool children, a positive association was reported between availability of backyard space and outdoor toys/equipment in the home and overall physical activity. The availability of physical activity programs and equipment within schools, and neighbourhood features such as pedestrian and cyclist safety structure were positively associated with physical activity in children and adolescents. Negative street characteristics, for example, lack of sidewalks and streetlights, were negatively associated with physical activity in adults. Inconsistent associations were reported for the majority of reviewed determinants in adults. Conclusion: This umbrella SLR provided a comprehensive overview of the physical environment determinants of physical activity across the life course and has highlighted, particularly amongst youth, a number of key determinants that may be associated with overall physical activity. Given the limited evidence drawn mostly from cross-sectional studies, longitudinal studies are needed to further explore these associations. Registration: PROSPERO CRD42015010616.

Published
2017

26. Behavioral determinants of physical activity across the life course: a 'DEterminants of DIet and Physical ACtivity' (DEDIPAC) umbrella systematic literature review

Author

Condello, G., Puggina, A., Aleksovska, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Simon, C., Ciarapica, D., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Kennedy, Ai., Ling, F.C.M., Luzak, A., Napolitano, G., Nazare, J.-A., Perchoux, C., Pesce, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., Ricciardi, W., MacDonncha, C., Capranica, L., and Boccia, S.

Subjects
Cardiovascular and Metabolic Diseases
Abstract

BACKGROUND: Low levels of physical activity (PA) are a global concern and increasing PA engagement is becoming a priority in current public health policies. Despite the large number of studies and reviews available, the evidence regarding the behavioral determinants of PA is still inconclusive. Thus, the aim of this umbrella systematic literature review (SLR) was to summarize the evidence on the behavioral determinants of PA across the life course. METHODS: A systematic online search was conducted on MEDLINE, ISI Web of Science, Scopus, and SPORTDiscus databases. The search was limited to studies published in English from January, 2004 to April, 2016. SLRs and meta-analyses (MAs) of observational studies that investigated the behavioral determinants of PA were considered eligible. The extracted data were assessed based on the importance of the determinants, the strength of evidence, and the methodological quality. The full protocol is available from PROSPERO (PROSPERO 2014:CRD42015010616). RESULTS: Seventeen reviews on 35 behavioral determinants of PA were eligible for this umbrella SLR. Regardless of age, the most investigated determinants were those related with 'screen use' and 'smoking'. For youth, probable positive evidence emerged for 'previous PA' and 'independent mobility and active transport' among children and adolescents. For the adult population, 'transition to university' and 'pregnancy/having a child' showed probable negative associations. CONCLUSIONS: Although the majority of the evidence was limited and most of the determinants were not associated with PA, this umbrella SLR provided a comprehensive overview of the associations between behavioral determinants and PA. Youth should be physically active in the early years and increase active transportation to/from school, independent mobility, and 'free-range activities' without adult supervision, whilst adult PA behaviors are mostly influenced by the life events. Finally, more research is needed that incorporates prospective study designs, standardized definitions of PA, objective measurement methods of PA assessment, and the use of interactionist and mediational approaches for the evaluation of different behavioral determinants influencing PA behaviors.

Published
2017

29. HIT Poster session 2P479Strain concordance in a real-world setting: experience in our laboratory after equipment upgradeP4803D echocardiography is a fast-learning and reliable method for the measurements of left atrial volumesP481Echocardiographic parameters associated with long-term appropriate antiarrhythmic therapies in cardiac resynchronization therapy defibrillator patientsP482Noninvasively measured global wasted myocardial work allows for quantitative assessment of typical left ventricular mechanical dyssynchrony pattern in patients with left bundle branch blockP483The impact of adherence to physical exercise on the improvement of cardiovascular remodeling and metabolic status in healthy untrained postmenopausal womenP484The impact of the latest chamber quantification recommendations on the prediction of left atrial appendage thrombus presenceP485The cardiac-enriched miRNAs plasma levels (miR-1, miR-133a, miR-499) reflect the impaired left ventricular systolic function and correlate with cardiac necrosis markers in early phase of NSTE-ACSP486Acute regional myocardial deformation changes in patients with severe aortic stenosis and preserved ejection fraction after isolated aortic valve replacementP487Left ventricular rotational deformation in asymptomatic patients with chronic aortic regurgitation and normal left ventricular ejection fraction P488The appropriate use of transthoracic echocardiography for the exclusion of infective endocarditisP489In patients with hypertrophic cardiomyopathy, left ventricular mass and shape by three-dimensional echocardiography are related with dynamic obstruction and functional capacityP490Mitral leaflet sizing in hypertrophic cardiomyopathy: impact of method and timingP491Echocardiographic predictors of atrial fibrillation in obese womenP492Echocardiographic risk factors for 30 day mortality after the hybrid procedure for hypoplastic left heart syndromeP493Left ventricular mass is an independent predictor of coronary flow reserve: insights from a single centre stress echo cohortP494Transesophageal echocardigoraphy uner conscious sedation for guiding cryoballoon pulmonary vein isolation in paroxysmal atrial fibrillation - the safety and feasibility studyP495Transesophageal echocardigoraphy under conscious sedation for guiding cryoballoon pulmonary vein isolation in paroxysmal atrial fibrillation - the safety and feasibility studyP496Three-dimensional trans-esophageal echocardiography assessment of the immediate morphological changes of the mitral annulus after percutaneous mitral edge-to-edge repairP497Clinical value of global and regional longitudinal strain in prediction of myocardial ischemia in asymptomatic diabetes type 2 patientsP499Comparison of prognostic operative risk impact on the global longitudinal strain right ventricle (GLS RV) and tricuspid annular plane systolic excursion (TAPSE) values in patients with ischemic cardioP498Right heart function in early diastolic dysfunction: 2D speckle-tracking echocardiography-based assessment of right atrial and right ventricular functionP500 Comparison of 2D, 3D transesophageal echocardiography and computed tomography during the assessment of left atrial appendage closure

Author

Cueva Recalde, JF., primary, Velcea, A., primary, Aguiar Rosa, S., primary, Surkova, E., primary, Bucciarelli, V., primary, Kupczynska, K., primary, Miskowiec, D., primary, Reskovic Luksic, V., primary, Verseckaite, R., primary, Jillott, N., primary, Muraru, D., primary, Borizanova, A., primary, Caroli, S., primary, Guerreiro, S., primary, Mahmoud, HM., primary, Peovska Mitevska, I., primary, Babukov, R., primary, Brecht, A., primary, Garcia-Sanchez, MJ., primary, Gayan Ordas, J., additional, Lacambra Blasco, I., additional, Mihaila, S., additional, Andronic, AA., additional, Marcu, S., additional, Vinereanu, D., additional, Galrinho, A., additional, Branco, L., additional, Timoteo, A., additional, Cunha, P., additional, Lousinha, A., additional, Valente, B., additional, Pereira Silva, T., additional, Oliveira, M., additional, Cruz Ferreira, R., additional, Aalen, J., additional, Samset, E., additional, Bidviene, J., additional, Aruta, P., additional, Romeo, G., additional, Sambugaro, F., additional, Badano, LP., additional, Muraru, D., additional, Bianco, F., additional, Di Blasio, A., additional, Izzicupo, P., additional, Ghinassi, B., additional, Napolitano, G., additional, Di Baldassarre, A., additional, Gallina, S., additional, Michalski, B., additional, Miskowiec, D., additional, Kasprzak, JD., additional, Lipiec, P., additional, Kupczynska, K., additional, Simiera, M., additional, Wejner-Mik, P., additional, Wierzbowska-Drabik, K., additional, Ojrzanowski, M., additional, Pasalic, M., additional, Separovic Hanzevacki, J., additional, Mizariene, V., additional, Montvilaite, A., additional, Unikaite, R., additional, Bieseviciene, M., additional, Jurkevicius, R., additional, Wilson, S., additional, Marotta, C., additional, Calore, C., additional, Surkova, E., additional, Palermo, C., additional, Iliceto, S., additional, Kinova, E., additional, Kundurzhiev, T., additional, Goudev, A., additional, Bellsham-Revell, HR., additional, Bell, AJ., additional, Miller, OI., additional, Simpson, JM., additional, Raposo, L., additional, Andrade, MJ., additional, Horta, E., additional, Reis, C., additional, Almeida, M., additional, Mendes, M., additional, Qawoq, HD., additional, Zycinski, P., additional, Wcislo, T., additional, Abdel Raouf, O., additional, Kheir, A., additional, Halawa, S., additional, Al-Ghamdi, M., additional, Ghabashi, A., additional, Srbinovska, E., additional, Antova, E., additional, Bosevski, M., additional, Bazilev, VV., additional, Bartosh, FL., additional, Bathe, M., additional, Oertelt-Prigione, S., additional, Seeland, U., additional, Regitz-Zagrosek, V., additional, Baumann, G., additional, Stangl, K., additional, Stangl, V., additional, Knebel, F., additional, Dreger, H., additional, Barreiro-Perez, M., additional, Arribas-Jimenez, A., additional, Martin-Garcia, A., additional, Diaz-Pelaez, E., additional, Rama-Merchan, JC., additional, Cruz-Gonzalez, I., additional, and Sanchez, PL., additional

Published
2016
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30. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

Author

Gerstein, Hertzel C, Colhoun, Helen M, Dagenais, Gilles R, Diaz, Rafael, Lakshmanan, Mark, Pais, Prem, Probstfield, Jeffrey, Riesmeyer, Jeffrey S, Riddle, Matthew C, Rydén, Lars, Xavier, Denis, Atisso, Charles Messan, Dyal, Leanne, Hall, Stephanie, Rao-Melacini, Purnima, Wong, Gloria, Avezum, Alvaro, Basile, Jan, Chung, Namsik, Conget, Ignacio, Cushman, William C, Franek, Edward, Hancu, Nicolae, Hanefeld, Markolf, Holt, Shaun, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A, Lopez-Jaramillo, Patricio, Cardona Munoz, Ernesto German, Pirags, Valdis, Pogosova, Nana, Raubenheimer, Peter J, Shaw, Jonathan E, Sheu, Wayne H-H, Temelkova-Kurktschiev, Theodora, Abella, Mercedes, Alebuena, Andrea, Almagro, Sandra, Amoroso, Eduardo, Anadon, Paula, Andreu, Elizabeth, Aristimuño, Guillermo, Arzadun, Maria, Barbieri, Maria, Barcudi, Raul, Bartolacci, Ines, Bolobanich, Gabriel, Bordonava, Anselmo, Bustamante Labarta, Miguel, Bustos, Betina, Caccavo, Alberto, Camino, Alejandra, Cantero, Maria, Carignano, Maria, Cartasegna, Luis, Cipullo, Marcela, Commendatore, Víctor, Conosciuto, Victoria, Costamagna, Osvaldo, Crespo, Claudia, Cuello, Jose, Cuneo, Carlos, Cusimano, Sandra, Dean, Sofia, Dituro, Claudio, Dominguez, Andrea, Farah, Miguel, Fernandez, Alberto, Fernandez, Florencia, Ferrari, Adriana, Flammia, Patricia, Fuentealba, Jose, Gallardo, Karina Beatriz, Garcia, Celso, Garcia Duran, Ruben, Garrido, Marcelo, Gavicola, Rodolfo, Gerbaudo, Claudio, Gilli, Graciela, Giotto, Ana Paula, Godoy Bolzán, Pedro, Gomez Vilamajo, Oscar, Guerlloy, Fernando, Guridi, Cristian, Gutierrez Garrido, Narcisa, Hasbani, Eduardo, Hermida, Sonia, Hominal, Miguel, Hrabar, Adrian, Ingaramo, Adrián, Izzicupo, Alejandra, Krynski, Mario, Lagrutta, Mariana, Lanchiotti, Paulina, Langhe, Maria, Leonard, Veronica, Llanos, Javier, Lopez Santi, Ricardo, Lowenstein, Jorge, Luquez, Cecilia, Mackinnon, Ignacio, Mana, Melina, Manzur, Sara, Marino, Javier, Martella, Carolina, Martinez, Roger, Matias, Re, Matkovich, Javier, Meritano, Monica, Montaña, Oscar, Mulazzi, María, Ochoa, Juan, Paterlini, Gustavo, Pelagagge, María, Peralta Lopez, Maria Elena, Prado, Aldo, Pruyas, Lorena, Racca, Martín, Ricotti, Carola, Rodriguez, Carolina, Romero Vidomlansky, Mariano, Ronderos, Ricardo, Sadowski, Ana Laura, Sala, Jorgelina, Sánchez, Alejandro, Santoro, Andrea, Schiavi, Lilia, Sein, Mariano, Sernia, Virginia, Serra, Leonardo, Sicer, Maximiliano, Smith, Tomas, Soso, Leonardo, Sposetti, Georgina, Steinacher, Andrea, Stival, Jorge, Tedesco, Jorge, Tonin, Hugo, Tortolo, Mauro, Ulla, Maria, Vallejos, Julio, Vico, Marisa, Virgillito, Luciana, Visco, Virginia, Vogel, Daniel, Waisman, Florencia, Zaidman, César, Zucchiatti, Noemi, Badshah, Imran, Cohen, Neale, Colman, Peter, Colquhoun, David, Davis, Timothy, Fourlanos, Spiros, Fulcher, Greg, Hamlyn, Jane, Haywood, Cilla, Hocking, Samantha, Huchinson, Maeve, Jeffries, William, Kyl, Mervyn, Lo, Clement, Mah, PeakMann, Makepeace, Ashley, Marope, Dolly, Nanayakkar, Natalie, Nankervis, Alison, Palmer, Neil, Palolus, Barbara, Pillai, Satish, Price, Sarah, Price, Sarah, Proietto, Joseph, Reutens, Anne, Rodrigo, Natassia, Sheikh, Abdul, Smith, Greg, So, Michelle, Soldatos, Georgia, Stuckey, Bronwyn, Sumithran, Priya, Teede, Helena, Vora, Parind, Williams, Lyn, Abib, Eduardo, Adão Poço, Christiani, Alves, Érica Ferreira, Andreatta Bernardi Barea, Janaina, Avezum Oliveira, Livia, Castro, Denise Ludovico da Costa de, Correa da Cruz, Ivan, Costa, Midiã, Cruz, Ivan, Cunha, Sidney, Da Silva, Marco Antonio Vieira, de Carvalho Camara Bona, Renata, de Paula, Bruna, Eliaschewitz, Freddy, Fazolli, Guilherme, Ferreira Filho, Carlos Alberto, Fortes, Jose, França, Cesar, Franco, Denise Reis, Genestreti, Paulo Roberto, Giorgeto, Flavio, Gonçalves, Rodrigo Marques, Grossman, Michele Elka, Henrique Marcelino, Ana Claudia, Hernandes, Mauro, Horta, Ana, Jaeger, Cristiano, Kaneblai, Midia, Kauffman Rutenberg, Cecilia, Kerr Saraiva, Jose Francisco, Lemos, Maria Angelica, Maia, Lilia, Manenti, Euler Roberto, Marques, Mariana, Melissa Valerio, Cynthia, Moreira, Rodrigo, Mothé, Flávia, Mouco, Osana Maria, Moura, Philip, Moura Jorge, José Carlos, Nakashima, Carlos, Nakazone, Marcelo, Napoli, Thiago, Nunes, Cristiane, Nunes Salles, Joao Eduardo, Oliveira, Karla, Oliveira, Marcela, Pantano, Gracielly de Souza, Petri, Fabio, Piazza, Leonardo, Pires, Andreia Carla, Pizzato, Patricia, Prata, Sergio, Precoma, Dalton, Rech, Rafael, Reis, Gilmar, Reis, Heleno, Resende, Elisabete, Ribas Fortes, Jose, Rodovalho, Sylka, Rossi dos Santos, Fabio, Salles, Joao Eduardo, Sampaio, Célia Regina, Santos, Thiago, Santos dos Santos, Vanessa, Silva e Quadros, Tulio, Silveira, Daniel, Siqueira, Katia Nunes, Teireira, M, Uehara, Marcelo, Valerio, C, Vianna, Henrique, Vidotti, Maria Helena, Visconti, Guilherme de Lima, Zanella, Maria Teresa, Andreeva, Viktoriya, Borisov, Radoslav, Botushanov, Nikolay, Dimitrov, Georgi, Dimova, Kameliya, Dragoychev, Tsvetan, Grigorova, Valentina, Gushterova, Valentina, Ivanov, Ivaylo, Kocelova, Tatyana, Kurktschiev, Dimo, Miletieva, Milena, Nenkova-Gugusheva, Neli, Pancheva, Ralitsa, Pavlova, Maria, Raev, Dimitar, Spasova, Vesela, Stoikov, Anastas, Troev, Dimitar, Yanev, Todor, Yoncheva-Mihaylova, Mariana, Abitbol, Alexander, Ajala, Buki, Alguwaihes, Abdullh, Ardilouze, Jean-Luc, Aris-Jilwan, Nahla, Arnaout, Amel, Aronson, Ronnie, Aslam, Nadeem, Babin, Sandra, Bailargeon, Jean-Patrice, Bailey, Allan, Bajaj, Harpreet, Beauchesne, Christian, Beca, Sorin, Belanger, Andre, Bell, Alan, Bellabarba, Diego, Berard, Lori, Berenbaum, Brian, Bergeron, Vincent, Berlingieri, Joseph, Bernier, Frédéric, Bishara, Phoebe, Blank, David, Blumer, Ian, Brault, Suzanne, Breton, Donald, Carpentier, André, Cha, James, Chandra, Prakash, Chiasson, Jean-Louis, Conway, James R, Couture, Ghyslaine, Couture, Nathalie, Dagenais, Gilles, Datta, Dyotirmoy, D'Ignazio, Giuseppe, Dumas, Richard, Fay, Didier, Frechette, Andre, Frenette, Louise, Fung, Daisy, Gagnon, Nathalie, Galter, Meri, Garon, Jean, Gauthier, Jean Sebastien, Geadah, Christian, Gilbert, Jeremy, Girard, Ronald, Goldenberg, Ronald, Grossman, Loren David, Gupta, Nikhil, Halle, Jean-Pierre, Hivert, Marie-France, Houde, Ghislaine, Houlden, Robyn, Hramiak, Irene, Jablonski, Ted, Jain, Akshay Jain, Khandwala, Hasnain, Khosla, Munish, Lachance, C, Laflamme, Emilie, Langlois, Marie-France, Larivee, Luc, Liutkus, Joanne, Lochnan, Heather, Malik, Saleem, McDonald, Charlotte, Mehta, Pravinsagar, Mihailidis, John, Milot, Alain, Narula, Priya, Nault, Patrice, Nayar, Arun, Nisker, William, Ouellet, Gilles, Palardy, Jean, Patel, Minta, Paul, Terri, Pedersen, Sue, Perron, Patrice, Pesant, Marie-Hélène, Poirier, Paul, Poulin, Marie-Claude, Punthakee, Zubin, Rehman, Waheed, Ross, Stuart, Sagar, P, Saliba, Nouhad, Sandler, Sam, Schiffrin, Alicia, Schlosser, Robert, Seth-Sharma, Anila, Sherman, Mark, Sionit, David, Sivakumar, Tharsan, Soto, Juan, St-Amour, Eric, Steen, Oren, Sussman, Jack, Telner, Adam, Tobe, Sheldon, Twum-Barima, David-Yaw, Van Zanten, Audrey, VanRossum, Nicole, Vecchiarelli, Jonathan, Ward, Rick, Wessengel, John, Weisnagel, Stanley, Wilderman, Igor, Woo, Vincent, Yakubovich, Natalia, Yale, Jean-Francois, Yared, Zeina, Acevedo, Monica, Aguirre, Maria Loreto, Aizman, Andres, Barroso, Maria Soledad, Cobos, Leonardo, Danin Vargas, Alfredo, Descalzi, Barbara, Godoy, Gonzalo, Grumberg, Elio, Lahsen, Rodolfo, Larenas, Gladys, Ortiz, Eugenia, Paredes, Javier, Potthoff, Sergio, Retamal, Eva, Rojas, Luis, Salgado, Manuel, Santibanez, Claudio, Solis, Carmen, Stokins, Benjamin, Accini, Jose, Acebedo, Javier, Agudelo Baena, Lina Maria, Alarcon, Soraya, Angel, Juliana, Arcos, Edgar, Aroca Martinez, M, Atuesta, Leonor, Balaguera, Jose, Ballestas, Doris, Barrera, Sandra Isabel, Barrios Reyes, Rosmy, Bayona, Adolfo, Bermudez, Andres, Bernal, Diego Zarate, Blanquicett, Marco, Bravo, Victor, Bueno, Wendy, Burbano Delgado, Alvaro, Cadena, Alberto, Cadena, Andres, Caicedo, Sandra, Celemin, Carlos, Consuegra, Ricardo, Contreras Pimienta, Cristhian, Corredor, Kelly Johenis, Cure, Carlos, De La Hoz Rueda, Lizeth Dayana, Delgado, Erika, Diaz, Sarahy, Diego, Marta, Donado, Anabell, Encinales Sanabria, William, Escobar, Juliana, Escorcia, Gillian, Forero, Leonardo, Fuentes, Laura, Garcia, Maria, Garcia Lozada, Henry, Garcia Ortiz, Luis, Giraldo, Angela, Gomez Gonzalez, Laura, Granada, Javier, Gutierrez, Corina, Henao, Natalia, Hernandez, Edwin, Herrera Uejbe, Olga Maria, Higuera Cobos, Juan Diego, Ibarra Gómez, Jaime, Jaimes, Edwin Hernandez, Jaramillo, Monica, Jaramillo, Nicolas, Jaramillo Gomez, Carlos, Jaramillo Sanchez, Monica, Jarava Durán, Ivonne, Lopez Ceballos, Catalina, Madrid, Claudia, María Amastha, Elias, Mercado, Jennifer, Molina, Dora Ines, Molina Soto, Jessica, Montoya, Carlos, Morales, Alexander, Muñoz, Carolina, Orozco, Luis Alejandro, Osorio, Oscar, Palmera Sanchez, Jorge Mario, Peña, Adwar, Perez, Jose, Perez Agudelo, Juan, Pérez Amador, Germán, Pertuz, Carlos, Posada, Irina, Puerta, Carlos, Quintero, Adalberto, Quiroz, Diana, Rendon, Carmen, Reyes, Alberto, Reyes, Alvaro, Ripoll, Diana, Rivera, Carlos, Rocha, Maria, Rodriguez, Jose F, Rodriguez Villanueva, Kervis Asid, Rodriguez Zabala, Javier Emilio, Rojas, Sindy, Romero, Maria, Rosero, Ricardo, Rosillo Cardenas, Angelica Rocio, Rueda, Lina, Sanchez, Gregorio, Sanchez, Tatiana, Sotomayor Herazo, Arístides, Suarez, Monica, Torres, Mariana, Trujillo, Freddy, Urina, Miguel, Van Strahlen, Lazaro, Velandia, Carlos, Velasquez Guzman, Carolina, Velazquez, Elizabeth, Vidal Prada, Tatiana, Yepez Alvaran, Juan Pablo, Zarate, Diego, Andelova, Jana, Benesova, Radka, Buzova, Barbara, Cech, Vladimir, Chodova, Ida, Choura, Miroslav, Dufka, Antonin, Gamova, Andrea, Gorgol, Jakub, Hala, Tomas, Havlova, Hana, Hlavkova, Dagmar, Horanska, Petra, Ilcisin-Valova, Juliana, Jenickova, Petra, Jerabek, Ondrej, Kantorova, Ilona, Kolomaznikova, Katerina, Kopeckova, Iva, Kopeckova, Miroslava, Linhart, Karel, Linhart, Tomas, Malecha, Jan, Malicherova, Emilia, Neubauerova, Dana, Oznerova, Martina, Partys, Radan, Pederzoliova, Eva, Petrusova, Maria, Prymkova, Vera, Racicka, Eva, Reissova, Ida, Roderova, Eva, Stanek, Libor, Striova, Alena, Svarcova, Dana, Svoboda, Petr, Szeghy Malicharova, Emilia, Urge, Jan, Vesely, Ladislav, Wasserburger, Bedich, Wasserburgerova, Hilde, Zahumensky, Emil, Zamrazil, Vaclav, Alawi, Hasan, Anastasiadis, Ernestos, Axthelm, Elisabeth, Bieler, Tasso, Buhrig, Christina, Degtyareva, Elizaveta, Dellanna, Frank, Derwahl, Karl-Michael, Diessel, Stephan, Dogiami, Barbara, Dorn-Weitzel, Kirsten, Ernst, Monika, Faulmann, Grit, Fetscher, Baerbel, Forst, Thomas, Freyer-Lahres, Gabriele, Funke, Klaus, Ganz, Xenia, Gleixner, Christiane, Hanefeld, Christoph, Heinrichs, Sven, Helleberg, Stephanie, Henkel, Elena, Hetzel, Gerd Ruediger, Hoffmann, Caren, Jacob, Frohmut, Jacob, Stephan, John, Franziska, Jonczyk, Antonius, Kamke, Wolfram, Klein, Christiane, Kleinhardt, Martina, Kleophas, Werner, Kosch, Christine, Kreutzmann, Kristin, Kühn, Achim, Lee-Barkey, Young Hee, Lier, Alexander, Maatouk, Sarah, Minnich, Joachim, Mitry, Michael, Muessig, Ilona, Nicula, Diana, Niemann, Martina, Nothroff, Joerg, Ott, Petra, Pfuetzner, Andreas, Pfützner, Andreas, Pistrosch, Frank, Pohl, Wildgard, Prochazkova, Zdenka, Retkowska, Marlena, Rosin, Heiko, Sachsenheimer, Daniela, Samer, Holger, Sanuri, Mazin, Schaefer, Axel, Schaper, Frank, Schulze, Erik-Delf, Schulze, Marita, Schumann, Martina, Segiet, Thomas, Sowa, Veronika, Stahl, Hans-Detlev, Steinfeldt, Franziska, Teige, Madlen, Trieb, Bjoern, Tschoepe, Diethelm, Uebel, Peter, Warken, Bernd, Weigmann, Ingo, Weyland, Klaus, Wilhelm, Klara, Balo, Timea, Balsay, Miklos, Bende, Ilona, Bezzegh, Katalin, Birkus, Zita, Buday, Barbara, Csomai, Melinda, Deak, Laszlo, Dezso, Eniko, Faludi, Peter, Faluvegi, M, Fazekas, Ilona, Feher, Agota, Fejer, Csaba, Finta, Ervin, Fulcz, Agnes, Gaal, Zsolt, Gurzo, Mihaly, Hati, Krisztina, Herczeg, Gabriella, Jozsef, Ildiko, Juhasz, Marta, Keltai, Katalin, Koranyi, Laszlo, Kulcsar, Eniko, Kun, Krisztina, Laczko, Andrea, Literáti-Nagy, Botond, Mezo, Izabella, Mileder, Margit, Moricz, I, Nagy, Károly, Nagybaczoni, Bela, Nemeth, Csaba, Oze, Agnes, Pauer, Jozsef, Peterfai, Eva, Polocsanyi, Bela, Poor, Ferenc, Reiber, István, Salamon, Csaba, Sebestyen, Julia, Torok, Ildiko, Tuu, Marianna, Varga, Andrea, Vass, Viktor, Ahn, Chul Min, Ahn, Chulwoo, ByungWon, Park, Chang, Hyuk-Jae, Chang, Kiyuk, Choi, Eui-Young, Choi, Han Seok, Chung, Jin-Wook, Hong, Bum- Kee, Hong, Young Joon, Hyon, Min Su, Jeong, Myung Ho, Kang, Shinae, Kim, Byeong-Keuk, Kim, Ji-Hyun, Kim, Ju Han, Kim, Kee-Sik, Kim, Kee-Sik, Kim, Moo Hyun, Kim, Pum-Joon, Kim, Soon-Kil, Kim, Yong-Seok, Kim, Young Kwon, Koh, Yoon Seok, Kwon, Hyuck Moon, Lee, Byoung Kwon, Lee, Byung-Wan, Lee, Jin Bae, Lee, Myoung-Mook, Lim, Young-Mee, Min, Pil Ki, Park, Jong Sung, Park, Jongsuk, Park, Keun Ho, Park, Sungha, Pyun, Wook Bum, Rim, Se Joong, Ryu, Dong-Ryeol, Seo, Hong-Seog, Seung, Ki Bae, Shin, Dong-Ho, Sim, Doo Sun, Yoon, Young Won, Andersone, Ilze, Babicka, Kristine, Balcere, Inga, Barons, Roberts, Capkovska, Inguna, Geldnere, Kristine, Grigane, Inese, Jegere, Baiba, Lagzdina, Ilze, Mora, Lija, Pastare, Sigita, Ritenberga, Rota, Romanova, Janina, Saknite, Inta, Sidlovska, Natalja, Sokolova, Jelena, Steina, Sandra, Strizko, Iveta, Teterovska, Dace, Vizina, Brigita, Barsiene, Lina, Belozariene, Gintare, Daugintyte-Petrusiene, Laura, Drungiliene, Nijole, Garsviene, Nijole, Grigiene, Ala, Grizas, Vytautas, Jociene, Virginija, Kalvaitiene, Dalia, Kaupiene, Jugeta, Kavaliauskiene, Jurate, Kozloviene, Dalia, Lapteva, Ilona, Maneikiene, Birute, Marcinkeviciene, Jolanta, Markauskiene, Vaidilija, Meiluniene, Salomeja, Norkus, Almantas, Norviliene, Rita, Petrenko, Vladimiras, Radzeviciene, Ruta, Sakalyte, Gintare, Urbonas, Gediminas, Urbutiene, Skaiste, Vasiliauskas, Donatas, Velickiene, Dzilda, Aguilar, Carlos, Alcocer, Marco, Avalos-Ramirez, Juan Antonio, Banda-Elizondo, Ramiro, Bricio-Ramirez, Rubria, Cardenas Mejia, Karla, Cavazos, Francisco, Chapa, Jesus, Cienfuegos, Erika, De la Peña, Astrid, de la Peña Topete, Gilberto, De los Rios Ibarra, Manuel Odin, Elias, Daniel, Flores-Moreno, Claudia, Garcia Hernandez, Pedro, Gonzalez, Luis Gerardo, Guerra Moya, Rosa Linda, Guerra-Lopez, Arturo, Hernandez Baylon, Raymundo, Herrera Colorado, Carolina, Herrera-Marmolejo, Marisol, Islas-Palacios, Neri, Lopez, Esteban, Lopez, Fernando, Lopez Alvarado, Agustin, Luna Ceballos, Rosa Isela, Morales Villegas, Enrique, Moreno-Virgen, Gualberto, Parra Perez, Rosa Linda, Pascoe Gonzalez, Sara, Peralta-Cantu, Irving, Previn, Roopa, Ramirez, Rosa, Ramirez, Rubria, Ramos Zavala, Maria Guadalupe, Rodriguez, Monica, Salgado-Sedano, Rocio, Sanchez-Aguilar, Ana Claudia, Santa Rosa Franco, Edith, Sauque-Reyna, Leobardo, Suarez Otero, Rodrigo, Torres, Ivonne, Velarde-Harnandez, Enrique, 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Ola, Okorocha, Yolanda, Ortiz Carrasquillo, Ramón, Osei, Kwame, Palermo, Coromoto, Patel, Hiren, Patel, Krishna, Pau, Cindy, Perley, Michael, Plevin, Sanford, Plummer, Elena, Powell, Richard, Qintar, Mohammed, Rawls, Rex, Reyes-Castano, John, Reynolds, Lillian, Richards, Robert, Rosenstock, Julio, Rowe, Caroline, Saleh, Jahandar, Sam, Sony, Sanchez, Alfredo, Sander, Donald, Sanderson, Bruce, Savin, Virginia, Seaquist, Elizabeth, Shah, Jayendra, Shi, Serena, Shivaswamy, Vijay, Shlotzhauer, Tammi, Shore, David, Skukowski, Bobbie, Soe, Kyaw, Solheim, Vesna, Soufer, Joseph, Steinberg, Helmut, Steinsapir, Jaime, Tarkington, Phillip, Thayer, Debra, Thomson, Stephen, Thrasher, James, Tibaldi, Joseph, Tjaden, Jeff, Tores, Oberto, Trence, Dace, Trikudanathan, Subbulaxmi, Ullal, Jagdeesh, Uwaifo, Gabriel, Vo, Anthony, Vu, Kenny, Walia, Damandeep, Weiland, Karen, Whitehouse, Fred, Wiegmann, Thomas, Wyne, Kathleen, Wynne, Alan, Yuen, Kevin, Zaretzky, Joel, Zebrack, James, Zieve, Franklin, and Zigrang, William

Abstract

Three different glucagon-like peptide-1 (GLP-1) receptor agonists reduce cardiovascular outcomes in people with type 2 diabetes at high cardiovascular risk with high glycated haemoglobin A1c(HbA1c) concentrations. We assessed the effect of the GLP-1 receptor agonist dulaglutide on major adverse cardiovascular events when added to the existing antihyperglycaemic regimens of individuals with type 2 diabetes with and without previous cardiovascular disease and a wide range of glycaemic control.

Published
2019
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31. Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial

Author

Gerstein, Hertzel C, Colhoun, Helen M, Dagenais, Gilles R, Diaz, Rafael, Lakshmanan, Mark, Pais, Prem, Probstfield, Jeffrey, Botros, Fady T, Riddle, Matthew C, Rydén, Lars, Xavier, Denis, Atisso, Charles Messan, Dyal, Leanne, Hall, Stephanie, Rao-Melacini, Purnima, Wong, Gloria, Avezum, Alvaro, Basile, Jan, Chung, Namsik, Conget, Ignacio, Cushman, William C, Franek, Edward, Hancu, Nicolae, Hanefeld, Markolf, Holt, Shaun, Jansky, Petr, Keltai, Matyas, Lanas, Fernando, Leiter, Lawrence A, Lopez-Jaramillo, Patricio, Cardona Munoz, Ernesto German, Pirags, Valdis, Pogosova, Nana, Raubenheimer, Peter J, Shaw, Jonathan E, Sheu, Wayne H-H, Temelkova-Kurktschiev, Theodora, Abella, Mercedes, Alebuena, Andrea, Almagro, Sandra, Amoroso, Eduardo, Anadon, Paula, Andreu, Elizabeth, Aristimuño, Guillermo, Arzadun, Maria, Barbieri, Maria, Barcudi, Raul, Bartolacci, Ines, Bolobanich, Gabriel, Bordonava, Anselmo, Bustamante Labarta, Miguel, Bustos, Betina, Caccavo, Alberto, Camino, Alejandra, Cantero, Maria, Carignano, Maria, Cartasegna, Luis, Cipullo, Marcela, Commendatore, Víctor, Conosciuto, Victoria, Costamagna, Osvaldo, Crespo, Claudia, Cuello, Jose, Cuneo, Carlos, Cusimano, Sandra, Dean, Sofia, Dituro, Claudio, Dominguez, Andrea, Farah, Miguel, Fernandez, Alberto, Fernandez, Florencia, Ferrari, Adriana, Flammia, Patricia, Fuentealba, Jose, Gallardo, Karina Beatriz, Garcia, Celso, Garcia Duran, Ruben, Garrido, Marcelo, Gavicola, Rodolfo, Gerbaudo, Claudio, Gilli, Graciela, Giotto, Ana Paula, Godoy Bolzán, Pedro, Gomez Vilamajo, Oscar, Guerlloy, Fernando, Guridi, Cristian, Gutierrez Garrido, Narcisa, Hasbani, Eduardo, Hermida, Sonia, Hominal, Miguel, Hrabar, Adrian, Ingaramo, Adrián, Izzicupo, Alejandra, Krynski, Mario, Lagrutta, Mariana, Lanchiotti, Paulina, Langhe, Maria, Leonard, Veronica, Llanos, Javier, Lopez Santi, Ricardo, Lowenstein, Jorge, Luquez, Cecilia, Mackinnon, Ignacio, Mana, Melina, Manzur, Sara, Marino, Javier, Martella, Carolina, Martinez, Roger, Matias, Re, Matkovich, Javier, Meritano, Monica, Montaña, Oscar, Mulazzi, María, Ochoa, Juan, Paterlini, Gustavo, Pelagagge, María, Peralta Lopez, Maria Elena, Prado, Aldo, Pruyas, Lorena, Racca, Martín, Ricotti, Carola, Rodriguez, Carolina, Romero Vidomlansky, Mariano, Ronderos, Ricardo, Sadowski, Ana Laura, Sala, Jorgelina, Sánchez, Alejandro, Santoro, Andrea, Schiavi, Lilia, Sein, Mariano, Sernia, Virginia, Serra, Leonardo, Sicer, Maximiliano, Smith, Tomas, Soso, Leonardo, Sposetti, Georgina, Steinacher, Andrea, Stival, Jorge, Tedesco, Jorge, Tonin, Hugo, Tortolo, Mauro, Ulla, Maria, Vallejos, Julio, Vico, Marisa, Virgillito, Luciana, Visco, Virginia, Vogel, Daniel, Waisman, Florencia, Zaidman, César, Zucchiatti, Noemi, Badshah, Imran, Cohen, Neale, Colman, Peter, Colquhoun, David, Davis, Timothy, Fourlanos, Spiros, Fulcher, Greg, Hamlyn, Jane, Haywood, Cilla, Hocking, Samantha, Huchinson, Maeve, Jeffries, William, Kyl, Mervyn, Lo, Clement, Mah, PeakMann, Makepeace, Ashley, Marope, Dolly, Nanayakkar, Natalie, Nankervis, Alison, Palmer, Neil, Palolus, Barbara, Pillai, Satish, Price, Sarah, Price, Sarah, Proietto, Joseph, Reutens, Anne, Rodrigo, Natassia, Sheikh, Abdul, Smith, Greg, So, Michelle, Soldatos, Georgia, Stuckey, Bronwyn, Sumithran, Priya, Teede, Helena, Vora, Parind, Williams, Lyn, Abib, Eduardo, Adão Poço, Christiani, Alves, Érica Ferreira, Andreatta Bernardi Barea, Janaina, Avezum Oliveira, Livia, Castro, Denise Ludovico da Costa de, Correa da Cruz, Ivan, Costa, Midiã, Cruz, Ivan, Cunha, Sidney, Da Silva, Marco Antonio Vieira, de Carvalho Camara Bona, Renata, de Paula, Bruna, Eliaschewitz, Freddy, Fazolli, Guilherme, Ferreira Filho, Carlos Alberto, Fortes, Jose, França, Cesar, Franco, Denise Reis, Genestreti, Paulo Roberto, Giorgeto, Flavio, Gonçalves, Rodrigo Marques, Grossman, Michele Elka, Henrique Marcelino, Ana Claudia, Hernandes, Mauro, Horta, Ana, Jaeger, Cristiano, Kaneblai, Midia, Kauffman Rutenberg, Cecilia, Kerr Saraiva, Jose Francisco, Lemos, Maria Angelica, Maia, Lilia, Manenti, Euler Roberto, Marques, Mariana, Melissa Valerio, Cynthia, Moreira, Rodrigo, Mothé, Flávia, Mouco, Osana Maria, Moura, Philip, Moura Jorge, José Carlos, Nakashima, Carlos, Nakazone, Marcelo, Napoli, Thiago, Nunes, Cristiane, Nunes Salles, Joao Eduardo, Oliveira, Karla, Oliveira, Marcela, Pantano, Gracielly de Souza, Petri, Fabio, Piazza, Leonardo, Pires, Andreia Carla, Pizzato, Patricia, Prata, Sergio, Precoma, Dalton, Rech, Rafael, Reis, Gilmar, Reis, Heleno, Resende, Elisabete, Ribas Fortes, Jose, Rodovalho, Sylka, Rossi dos Santos, Fabio, Salles, Joao Eduardo, Sampaio, Célia Regina, Santos, Thiago, Santos dos Santos, Vanessa, Silva e Quadros, Tulio, Silveira, Daniel, Siqueira, Katia Nunes, Teireira, M, Uehara, Marcelo, Valerio, C, Vianna, Henrique, Vidotti, Maria Helena, Visconti, Guilherme de Lima, Zanella, Maria Teresa, Andreeva, Viktoriya, Borisov, Radoslav, Botushanov, Nikolay, Dimitrov, Georgi, Dimova, Kameliya, Dragoychev, Tsvetan, Grigorova, Valentina, Gushterova, Valentina, Ivanov, Ivaylo, Kocelova, Tatyana, Kurktschiev, Dimo, Miletieva, Milena, Nenkova-Gugusheva, Neli, Pancheva, Ralitsa, Pavlova, Maria, Raev, Dimitar, Spasova, Vesela, Stoikov, Anastas, Troev, Dimitar, Yanev, Todor, Yoncheva-Mihaylova, Mariana, Abitbol, Alexander, Ajala, Buki, Alguwaihes, Abdullh, Ardilouze, Jean-Luc, Aris-Jilwan, Nahla, Arnaout, Amel, Aronson, Ronnie, Aslam, Nadeem, Babin, Sandra, Bailargeon, Jean-Patrice, Bailey, Allan, Bajaj, Harpreet, Beauchesne, Christian, Beca, Sorin, Belanger, Andre, Bell, Alan, Bellabarba, Diego, Berard, Lori, Berenbaum, Brian, Bergeron, Vincent, Berlingieri, Joseph, Bernier, Frédéric, Bishara, Phoebe, Blank, David, Blumer, Ian, Brault, Suzanne, Breton, Donald, Carpentier, André, Cha, James, Chandra, Prakash, Chiasson, Jean-Louis, Conway, James R, Couture, Ghyslaine, Couture, Nathalie, Dagenais, Gilles, Datta, Dyotirmoy, D'Ignazio, Giuseppe, Dumas, Richard, Fay, Didier, Frechette, Andre, Frenette, Louise, Fung, Daisy, Gagnon, Nathalie, Galter, Meri, Garon, Jean, Gauthier, Jean Sebastien, Geadah, Christian, Gilbert, Jeremy, Girard, Ronald, Goldenberg, Ronald, Grossman, Loren David, Gupta, Nikhil, Halle, Jean-Pierre, Hivert, Marie-France, Houde, Ghislaine, Houlden, Robyn, Hramiak, Irene, Jablonski, Ted, Jain, Akshay Jain, Khandwala, Hasnain, Khosla, Munish, Lachance, C, Laflamme, Emilie, Langlois, Marie-France, Larivee, Luc, Liutkus, Joanne, Lochnan, Heather, Malik, Saleem, McDonald, Charlotte, Mehta, Pravinsagar, Mihailidis, John, Milot, Alain, Narula, Priya, Nault, Patrice, Nayar, Arun, Nisker, William, Ouellet, Gilles, Palardy, Jean, Patel, Minta, Paul, Terri, Pedersen, Sue, Perron, Patrice, Pesant, Marie-Hélène, Poirier, Paul, Poulin, Marie-Claude, Punthakee, Zubin, Rehman, Waheed, Ross, Stuart, Sagar, P, Saliba, Nouhad, Sandler, Sam, Schiffrin, Alicia, Schlosser, Robert, Seth-Sharma, Anila, Sherman, Mark, Sionit, David, Sivakumar, Tharsan, Soto, Juan, St-Amour, Eric, Steen, Oren, Sussman, Jack, Telner, Adam, Tobe, Sheldon, Twum-Barima, David-Yaw, Van Zanten, Audrey, VanRossum, Nicole, Vecchiarelli, Jonathan, Ward, Rick, Wessengel, John, Weisnagel, Stanley, Wilderman, Igor, Woo, Vincent, Yakubovich, Natalia, Yale, Jean-Francois, Yared, Zeina, Acevedo, Monica, Aguirre, Maria Loreto, Aizman, Andres, Barroso, Maria Soledad, Cobos, Leonardo, Danin Vargas, Alfredo, Descalzi, Barbara, Godoy, Gonzalo, Grumberg, Elio, Lahsen, Rodolfo, Larenas, Gladys, Ortiz, Eugenia, Paredes, Javier, Potthoff, Sergio, Retamal, Eva, Rojas, Luis, Salgado, Manuel, Santibanez, Claudio, Solis, Carmen, Stokins, Benjamin, Accini, Jose, Acebedo, Javier, Agudelo Baena, Lina Maria, Alarcon, Soraya, Angel, Juliana, Arcos, Edgar, Aroca Martinez, M, Atuesta, Leonor, Balaguera, Jose, Ballestas, Doris, Barrera, Sandra Isabel, Barrios Reyes, Rosmy, Bayona, Adolfo, Bermudez, Andres, Bernal, Diego Zarate, Blanquicett, Marco, Bravo, Victor, Bueno, Wendy, Burbano Delgado, Alvaro, Cadena, Alberto, 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Abstract

Two glucagon-like peptide-1 (GLP-1) receptor agonists reduced renal outcomes in people with type 2 diabetes at risk for cardiovascular disease. We assessed the long-term effect of the GLP-1 receptor agonist dulaglutide on renal outcomes in an exploratory analysis of the REWIND trial of the effect of dulaglutide on cardiovascular disease.

Published
2019
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32. Ghrelin and Growth Hormone Secretagogue Receptor localization in human iris and ciliar body

Author

Di Fonso, A., D’Amico, M.A., Izzicupo, P., Ghinassi, B., Zappacosta, R., Liberatore, M., Gallenga, C.E., Gallenga, P.E., and Di Baldassarre, A.

Subjects
Ghrelin, ciliar body, iris, pigmented epithelium, hormones, hormone substitutes, and hormone antagonists
Abstract

Ghrelin (Ghr) is a 28-amino acid peptide identified as endogenous, acylated ligand for the growth hormone (GH) secretagogue G-protein-coupled receptor (GHSR). Mainly synthesized from X/A like neuroendocrin cells of gastric fundus, Ghr acts directly on the pituitary gland inducing GH release; moreover Ghr regulates food intake resulting tightly associated with obesity. Several studies reported that Ghr is widely expressed in different tissues and, besides its orexigenic activity, effects on cardiovascular, pulmonary, reproductive and central nervous systems have been described. Recently, functional studies on rats and rabbits indicated Ghr as modulator of iris smooth muscles activity since induces relaxation of both sphincter and dilator muscles. Moreover Ghr mRNA has been found in the ciliary epithelium of ciliar body (CB). On the basis of these observations, we purposed to investigate Ghr and GHSR expression in human eye. The immunohistochemical analysis performed on iris and ciliar body specimens from post-traumatic explanted human eyeballs evidenced that Ghr and its receptor were co-expressed from the pigmented epithelium (PE) of both iris and CB, whereas we did not detect immunoreactivity in smooth muscle cells. Since human ciliar epithelium is a major site of production of neuroendocrine peptides found in aqueous humor (AqH), we analyzed AqH for the Ghr presence but the Enzymatic Immunoassay performed on 80 samples gave always negative results. In conclusion, our data suggest that Ghr may activate autocrine/paracrine signalling in human PE of CB and iris; the absence of GHSR- immunoreactivity on iris smooth muscle cells seem to rule out the possibility that Ghr can exert its myo-active effects directly., Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012

Published
2013
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33. Amniotic Fluid Stem Cells cardiomyogenic potential: a preliminary study

Author

D'Amico, M.A., Antonucci, I., Di Fonso, A., Bascelli, A., Ghinassi, B., Izzicupo, P., Stuppia, L., and Di Baldassarre, A.

Subjects
hAFSCs, EBs, cardiomyocitic differentiation
Abstract

The characterization of Amniotic Fluid-derived multipotent Stem Cells (AFSCs) open new paths in stem cell research. hAFSCs have characteristics intermediate between pluripotent embryonic- (ESCs) and lineage-restricted adult stem cells, and are non-tumorigenic and low immunogenic. Moreover, they are obtained without destroying human embryos, so that most of the ethical and social controversy could be prevented. We previously observed that human AFSCs express some genes specific of ESCs and primordial germ cells. We also shown hAFSCs ability to form in vitro three-dimensional aggregates of cells known as embryoid bodies (EBs), that express three germ layer markers. Recent studies reported the ability of hAFSCs to differentiate in vitro into adipocytes and osteocytes. Aim of our study was to analyse the cardiomyogenic potential of hAFSCs. EBs were obtained by modified hanging drops protocol from hAFSCs coltured in presence of ascorbic acid and 5-aza-2’-deoxycytidine (differentiation medium: DM). RT-PCR and Western Blotting analysis conducted on AFSCs and EBs cells evidenced the gene and protein expression of the transcriptor factor Nkx2.5, the earliest marker of heart precursor cells. Immunofluorescence (IF) analysis performed on EBs after 10 days in DM evidenced the cytoplasmic presence of α-myosin heavy chain (α-MHC) organized in parallel, oriented filamets. Microscopical analysis evidenced beating cells mainly at the periphery of the EB. In conclusion, our results evidenced that hAFSCs cultured in permissive conditions give rise to EB able to terminally differentiate in cardiomyocytes., Italian Journal of Anatomy and Embryology, Vol 117, No 2 (Supplement) 2012

Published
2013
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35. Heart rate variability, recovery and stress analysis of an elite rally driver and co-driver during a competition period

Author

Di Credico, Andrea, Petri, Cristian, Cataldi, Stefania, Greco, Gianpiero, Suarez-Arrones, Luis, and Izzicupo, Pascal

Abstract

To ensure both optimal health and performances, monitoring physiological and psychological states is of main importance for athletes. It is well known that monitoring heart rate variability and using validated questionnaires is useful for monitoring both the health and training status of athletes of different sports. Motorsports such as rally require high levels of physical and mental preparation thus information about psychophysiological status of rally athletes is fundamental. The aimof this study was to assess the autonomic regulation, stress, recovery conditions of one driver and one co-driver competing at the Italian National Rally Championship during their competition period. Heart rate variability parameters, acute recovery and stress states were assessed the day before, during the two days of race and the day following the races. Results showed that driver and co-driver had a sharp decrease of mean RR intervals, root mean square of successive differences between normal heartbeats, and standard deviation of the N-N interval during race days, while the stress index showed the inverse trend, and this behaviour was clearly visible in the Poincaré plots and power spectrum density graphs. The acute recovery and stress states questionnaire showed significant differences in recovery and stress scoring for the driver but not for the co-driver, although the trends were similar. This study describes the psychophysiological demands of a rally competition period suggesting that a daily evaluation of heart rate variability, recovery, stress states is useful for monitoring health status in rally athletes and could be implemented to make decision about training and recovery strategies.

Published
2024
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37. HIT Poster session 2P486The effect of short term aerobic exercise and ACE polymorphism on cardiovascular remodeling in healthy sedentary postmenopausal womenP487Are there predictors of malignant progression of aortic stenosis severity?P488Quantitative und semiquantitative parameters in the classification of aortic insufficiency: a 3D-echocardiography and magnet resonance imaging studyP489Vascular indicies surrogate markers for left ventricular dysfunctionP490Left ventricular systolic strain data does not require indexation to cavity size in mitral valve diseasesP491Impact of EACVI grant programme on career progression of grant winnersP492Early predictor of atrial fibrillation recurrence after electrical cardioversion: diastolic parameters come firstP493Echocardiographic diagnosis of arrhythmias in the fetusP4943D echocardiography is a fast-learning and a more reliable method compared with 2D echocardiography for the assessment of left ventricular volumes and ejection fraction in patients with heart failureP495Right ventricular mechanics in functional ischemic mitral regurgitation in acute inferior myocardial infarctionP496Added value of two dimentional strain in assessement of left ventricular systolic function in rheumatic mitral stenosis patients with normal ejection fractionP497Left ventricular myocardial deformation in arterial hypertension with different types of glucose metabolism disordersP498Epicardial to pericardial adipose tissue ratio: predicting myocardial ischemia in patients referred for exercise stress echocardiographyP499Echocardiographic evaluation of the patients with asd after percutaneous closureP500Screening for carotid artery stenosis with the use of pocket-size imaging device equipped with linear probeP501LAD correlates poorly with LAVIP502Predictors associated with the diastolic dysfunction formation in patients with moderate hypertensionP503Assessment of left atrial function by speckle tracking analysis in transthoracic echocardiography for predicting the presence of left atrial appendage thrombus in patients with atrial fibrillationP504can echocardiography detect subclinical myocardial damage in the layers of myocardial wall? (The first study in a large population with known inflammatory disease)P505Epicardial fat thickness and galectin 3 in patients with atrial fibrillation and metabolic syndromeP506Left ventricular reverse remodeling in heart failure: a new obesity paradox?P507Epicardial adipose tissue and carotid intima media thickness in hemodialysis patients; single center experienceP508Echocardiographic parameters of mitral valve remodeling associated with poor clinical outcome in high risk patients with functional mitral regurgitation after Mitraclip implantationP509Prevalence of valve disease in a community population over the age of 60P510Discordance between mitral valve area and mean transmitral pressure gradient in mitral stenosis: Is mean gradient marker of the severity or parameter of tolerance in severe mitral stenosis?P511Ischemic mitral regurgitation is associated with impaired radial and circumferential myocardial deformation in acute inferoposterior myocardial infarctionP512The importance of early left atrial functional changes in predicting long term left ventricular remodeling in patients surviving a ST elevation myocardial infarctionP513Remodeling of myocardial deformation after mitral valve surgeryP514Global longitudinal peak systolic strain is reduced shortly after heart transplantationP515Detailed transthoracic and transesophageal echocardiographic analysis of mitral leaflets in patient undergoing mitral valve repair

Author

Bucciarelli, V, primary, Avenatti, E, primary, Rosner, SJ, primary, Cherneva, ZHCH, primary, Li, H, primary, Surkova, E A, primary, Degiovanni, A, primary, Ortiz Garrido, A, primary, Mihaila, S, primary, Tamulenaite, E, primary, Amorouayeche, F Z, primary, Kolesnyk, M Y, primary, Garcia Campos, A, primary, Savcioglu, AS, primary, Filipiak, D, primary, Kuusisto, J K, primary, Torbas, O, primary, Kupczynska, K, primary, Tountas, X, primary, Ionin, VA, primary, Cescau, A, primary, Altin, C, primary, Ferreiro Quero, C, primary, Lowery, C, primary, Najih, H, primary, Valuckiene, Z, primary, Onciul, S, primary, Yang, L-T, primary, Baricevic, Z, primary, Ghulam Ali, S, primary, Bianco, F, additional, Izzicupo, P, additional, Ghinassi, B, additional, Di Baldassarre, A, additional, Gallina, S, additional, Milazzo, V, additional, Milan, A, additional, Patel, A, additional, Kuvin, J, additional, Pandian, N, additional, Orban, M, additional, Nadjiri, J, additional, Lesevic, H, additional, Hadamitzky, M, additional, Sonne, C, additional, Kuneva, ZK, additional, Vasilev, DV, additional, Yuan, L, additional, Xie, MX, additional, Jin, XY, additional, Muraru, D, additional, Grapsa, J, additional, Donal, E, additional, Lancellotti, P, additional, Habib, G, additional, Badano, L P, additional, Buffa, MC, additional, De Vecchi, F, additional, Prenna, E, additional, Boggio, E, additional, Marino, P, additional, De La Chica, J, additional, Cuenca Peiro, V, additional, Picazo Angelin, B, additional, Conejo Munoz, L, additional, Narbona, I, additional, Anderica, JR, additional, De Mora, M, additional, Zabala Arguelles, JI, additional, Velcea, A, additional, Matei, L, additional, Andronic, A, additional, Calin, S, additional, Rimbas, R, additional, Badano, LP, additional, Vinereanu, D, additional, Ovsianas, J, additional, Valuckiene, Z, additional, Jurkevicius, R, additional, Latreche, S, additional, Benkhedda, S, additional, Dzyak, G V, additional, Riznyk, Y Y, additional, Kovalyova, O V, additional, Velasco-Alonso, E, additional, Colunga-Blanco, S, additional, Martin-Fernandez, M, additional, Corros-Vicente, C, additional, Rodriguez-Suarez, ML, additional, Leon-Aguero, V, additional, De La Hera Galarza, JM, additional, Safak, O, additional, Nazli, C, additional, Akyildiz Akcay, F, additional, Yakar Tuluce, S, additional, Kahya Eren, N, additional, Ozdemir, E, additional, Kocabas, U, additional, Kasprzak, JD, additional, Lipiec, P, additional, Jarvinen, VM, additional, Sinisalo, JP, additional, Sirenko, YU, additional, Radchenko, G, additional, Rekovets, O, additional, Kushnir, S, additional, Michalski, BW, additional, Miskowiec, D, additional, Wdowiak-Okrojek, K, additional, Wejner-Mik, P, additional, Beldekos, D, additional, Protogerou, A, additional, Gournizakis, A, additional, Panopoulos, S, additional, Theodosis-Georgilas, A, additional, Fousas, S, additional, Sfikakis, P, additional, Soboleva, AV, additional, Listopad, OV, additional, Nifontov, SE, additional, Polyakova, EA, additional, Belyaeva, OD, additional, Baranova, EI, additional, Shlyachto, EV, additional, Baudet, M, additional, Cohen-Solal, A, additional, Logeart, D, additional, Sakallioglu, O, additional, Aydin, E, additional, Yilmaz, M, additional, Sade, LE, additional, Muderrisoglu, H, additional, Mesa Rubio, M D, additional, Ruiz Ortiz, M, additional, Delgado Ortega, M, additional, Sanchez Fernandez, J, additional, Duran Jimenez, E, additional, Morenate Navio, C, additional, Romero, M, additional, Pan, M, additional, Suarez De Lezo, J, additional, Frenneaux, M P, additional, Parasuraman, S K, additional, Rudd, A E, additional, Srinivasan, J, additional, Elbaghdadi, D, additional, Laarej, A, additional, Allouch, M, additional, Azzouzi, L, additional, Habbal, R, additional, Mizariene, V, additional, Ablonskyte-Dudoniene, R, additional, Cucchini, U, additional, Miglioranza, MH, additional, Dorobantu, M, additional, Iliceto, S, additional, Tsai, WC, additional, Cikes, M, additional, Ljubas Macek, J, additional, Skoric, B, additional, Skorak, I, additional, Jurin, H, additional, Samardzic, J, additional, Gasparovic, H, additional, Milicic, D, additional, Separovic Hanzevacki, J, additional, Fusini, L, additional, Tamborini, G, additional, Gripari, P, additional, Muratori, M, additional, Celeste, F, additional, Carminati, MC, additional, Alamanni, F, additional, and Pepi, M, additional

Published
2015
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38. Psychophysical health status of breast cancer survivors and effects of 12 weeks of aerobic training.

Author

Di Blasio, Andrea, Morano, Teresa, Cianchetti, Ettore, Gallina, Sabina, Bucci, Ines, Di Santo, Serena, Tinari, Camilla, Di Donato, Francesco, Izzicupo, Pascal, Di Baldassarre, Angela, Cimini, Alessandra, and Napolitano, Giorgio

Abstract

The aim of this study was to analyse the health status of breast cancer survivors and the effects of 12 weeks of aerobic training. Twenty-three breast cancer survivors (51.71 ± 3.17 years) and 23 healthy women (50.73 ± 2.97 years) were investigated for body composition, daily physical activity, quality of life, salivary cortisol, and DHEA-S. Breast cancer survivors were then aerobically trained for 12 weeks. Breast cancer survivors have a worse psychophysical health than healthy women. Aerobic training increased salivary DHEA-S, aerobic fitness, self-reported health, and nocturnal sleeping time and reduced salivary cortisol in breast cancer survivors. Salivary cortisol variation correlated with change of sleeping time and self-reported health. Salivary DHEA-S correlated with change of self-reported physical pain and general health as well. Breast cancer survivors can live in a situation of continuous distress, requiring a multidisciplinary approach. Twelve weeks of aerobic training improve the psychophysical health of breast cancer survivors. [ABSTRACT FROM AUTHOR]

Published
2017
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43. Lifestyle and high density lipoprotein cholesterol in postmenopause.

Author

Di Blasio, A., Bucci, I., Ripari, P., Giuliani, C., Izzicupo, P., Di Donato, F., D'Angelo, E., and Napolitano, G.

Subjects
LIFESTYLES, HIGH density lipoproteins, POSTMENOPAUSE, HUMAN body composition, BLOOD lipoproteins, LOGISTIC regression analysis, PHYSIOLOGY
Abstract

Objectives Menopause is characterized by hormonal and metabolic changes. These are linked to increased risk of cardiovascular disease, for which low blood plasma levels of high density lipoprotein (HDL) cholesterol are an independent risk factor. The present study investigated variables linked with basal plasma HDL cholesterol levels and the effects of aerobic training, on their variations, in 40 postmenopausal women. Methods We assessed body composition, dietary habits and maximal aerobic capacity of participants. Characteristics of daily physical activity and plasma lipoproteins were measured. The women walked on 4 days/week, for 14 weeks, at moderate intensity, and they were grouped according to the resulting tertiles of basal plasma HDL cholesterol levels. Results Logistic regression analysis showed that waist-to-hip ratio and number of daily bouts of moderate-intensity physical activity, held for at least 10 consecutive minutes (B10m/day), are predictive variables of basal plasma HDL cholesterol levels. After the training period, the first and second tertiles increased plasma HDL cholesterol levels, while the third tertile decreased plasma HDL cholesterol levels. The tertiles showed different remodelling of spontaneous physical activity: the third tertile reduced B10m/day, while the others did not. Conclusions This study provides knowledge about the relationships of plasma HDL cholesterol levels with characteristics of physical activity. Furthermore, it shows that physical exercise engagement can result in negative compensation of spontaneous physical activity that could counteract or reduce the positive effects of the aerobic training on plasma HDL cholesterol levels. [ABSTRACT FROM AUTHOR]

Published
2014
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44. NAD(P)H oxidase p22phox polymorphism and cardiovascular function in amateur runners.

Author

Gallina, S., Di Francescomarino, S., Di Mauro, M., Izzicupo, P., D'Angelo, E., D'Amico, M.A., Pennelli, A., Amicarelli, F., and Di Baldassarre, A.

Subjects
NADPH oxidase, GENETIC polymorphisms, CARDIOVASCULAR system, RUNNERS (Sports), ENZYME kinetics, EXERCISE, HEALTH
Abstract

Aim NAD(P)H system represents the major source of superoxide production at cardiovascular ( CV) level. It has several genetic variants: in particular, the C242T polymorphism of its p22phox subunit is associated with a different oxidase activity, being the T allele related to a lower superoxide production. Although several authors investigated the protective effect of T allele in CV diseases, only few data are available on its functional role in physiological conditions. The aim of our study was to investigate the relationship between the p22phox C242T polymorphism and CV function in amateur runners. Methods Seventy-three male amateur runners were screened for CYBA polymorphism. CV analysis was performed by echocardiographic-Doppler examination and by PulsePen tonometer assessment. Results The genetic subgroups ( CC and CT/ TT) did not differ for VMO2max and cardiac dimension. Nevertheless, T carriers ( n = 40) were characterized by a more efficient myocardial contraction and left ventricular ( LV) filling, as evidenced by significant higher values of the midwall fractional shortening, systolic excursion of the tricuspid annular plane and of early/late diastolic wave velocities ratio and by a lower E wave deceleration time. Pulse wave velocity and augmentation index, parameters related to the arterial stiffness, were higher in CC subjects compared with CT/ TT also when the analysis was adjusted for weight and diastolic pressure. Conclusion In amateur runners, CYBA variants may influence both systolic and diastolic function and arterial stiffness. We suppose that the lower oxidative activity that characterizes 242T subjects may positively influence the excitation-contraction and arterial-ventricular coupling mechanisms, thus leading to a more efficient CV function. [ABSTRACT FROM AUTHOR]

Published
2012
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46. Biological function and clinical relevance of chromogranin A and derived peptides

Author

D'amico, Maria Angela, Ghinassi, Barbara, Izzicupo, Pascal, Manzoli, Lamberto, and Di Baldassarre, A

Abstract

Chromogranin A (CgA (CHGA)) is the major soluble protein co-stored and co-released with catecholamines and can function as a pro-hormone by giving rise to several bioactive peptides. This review summarizes the physiological functions, the pathogenic implications, and the recent use of these molecules as biomarkers in several pathological conditions. A thorough literature review of the electronic healthcare databases MEDLINE, from January 1985 to September 2013, was conducted to identify articles and studies concerned with CgA and its processing. The search strategies utilized keywords such as chromogranin A, vasostatins 1 and 2, chromofungin, chromacin, pancreastatin, catestatin, WE14, chromostatin, GE25, parastatin, and serpinin and was supplemented by the screening of references from included papers and review articles. A total of 209 English-language, peer-reviewed original articles or reviews were examined. The analysis of the retrospective literature suggested that CgA and its several bioactive fragments exert a broad spectrum of regulatory activities by influencing the endocrine, the cardiovascular, and the immune systems and by affecting the glucose or calcium homeostasis. As some peptides exert similar effects, but others elicit opposite responses, the regulation of the CgA processing is critical to maintain homeostasis, whereas an unbalanced production of peptides that exert opposing effects can have a pathogenic role in several diseases. These clinical implications entail that CgA and its derived peptides are now used as diagnostic and prognostic markers or to monitor the response to pharmacological intervention not only in endocrine tumors, but also in cardiovascular, inflammatory, and neuropsychiatric diseases.

Published
2014
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47. Walking training affects dehydroepiandrosterone sulfate and inflammation independent of changes in spontaneous physical activity

Author

Izzicupo, Pascal, D’Amico, Maria Angela, Bascelli, Adriana, Di Fonso, Alessia, D’Angelo, Emanuele, Di Blasio, Andrea, Bucci, Ines, Napolitano, Giorgio, Gallina, Sabina, and Di Baldassarre, Angela

Abstract

We hypothesized that physical exercise in postmenopausal women could interfere with the molecular interrelationship of the immune-endocrine system and be effective even in women in whom training determined a reduction of spontaneous physical activity (SPA). For this reason, we investigated the effects of an aerobic program on plasma dehydroepiandrosterone sulfate (DHEA-S) and cytokine levels in relationship to SPA modification.

Published
2013
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49. Socio-cultural determinants of physical activity across the life course: a 'Determinants of Diet and Physical Activity' (DEDIPAC) umbrella systematic literature review

Author

Jaeschke, L., Steinbrecher, A., Luzak, A., Puggina, A., Aleksovsak, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Condello, G., Coppinger, T., Cortis, C., De Craemer, M., D'Haese, S., Di Blasio, A., Hansen, S., Ling, F.C.M., Lacoviello, L., Issartel, J., Izzicupo, P., Kanning, M., Kennedy, A., Napolitano, G., Nazare, J-A., Perchoux, C., Polito, A., Ricciardi, W., Sannella, A., Schlicht, W., Sohun, R., MacDonncha, C., Boccia, S., Capranica, L., Schulz, H., Pischon, T., Jaeschke, L., Steinbrecher, A., Luzak, A., Puggina, A., Aleksovsak, K., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Condello, G., Coppinger, T., Cortis, C., De Craemer, M., D'Haese, S., Di Blasio, A., Hansen, S., Ling, F.C.M., Lacoviello, L., Issartel, J., Izzicupo, P., Kanning, M., Kennedy, A., Napolitano, G., Nazare, J-A., Perchoux, C., Polito, A., Ricciardi, W., Sannella, A., Schlicht, W., Sohun, R., MacDonncha, C., Boccia, S., Capranica, L., Schulz, H., and Pischon, T.

Abstract

Objective Regular physical activity (PA) reduces the risk of disease and premature death. Knowing factors associated with PA might help reducing the disease and economic burden caused by low activity. Studies suggest that socio-cultural factors may affect PA, but systematic overviews of findings across the life course are scarce. This umbrella systematic literature review (SLR) summarizes and evaluates available evidence on socio-cultural determinants of PA in children, adolescents, and adults. Methods This manuscript was drafted following the recommendations of the ‘Preferred Reporting Items for Systematic reviews and Meta-Analyses’ (PRISMA) checklist. The MEDLINE, Web of Science, Scopus, and SPORTDiscus databases were searched for SLRs and meta-analyses (MAs) on observational studies published in English that assessed PA determinants between January 2004 and April 2016. The methodological quality was assessed and relevant information on socio-cultural determinants and any associations with PA was extracted. The available evidence was evaluated based on the importance of potential determinants and the strength of the evidence. Results Twenty SLRs and three MAs encompassing 657 eligible primary studies investigated potential socio-cultural PA determinants, with predominantly moderate methodological quality. Twenty-nine potential PA determinants were identified that were primarily assessed in children and adolescents and investigated the micro-environmental home/household level. We found probable evidence that receiving encouragement from significant others and having a companion for PA were associated with higher PA in children and adolescents, and that parental marital status (living with partner) and experiencing parental modeling were not associated with PA in children. Evidence for the other potential determinants was limited, suggestive, or non-conclusive. In adults, quantitative and conclusive data were scarce. Conclusions A substantial number of SLRs and MAs

50. Socio-economic determinants of physical activity across the life course: a 'DEterminants of DIet and Physical ACtivity' (DEDIPAC) umbrella literature review

Author

Kennedy, A., O'Donoghue, G., Puggina, A., Aleksovska, A., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Colloto, M., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Ling, F.C.M., Luzak, A., Napolitano, G., Nazare, J-A., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., MacDonncha, C., Capranica, L., Boccia, S., Kennedy, A., O'Donoghue, G., Puggina, A., Aleksovska, A., Buck, C., Burns, C., Cardon, G., Carlin, A., Chantal, S., Ciarapica, D., Colloto, M., Condello, G., Coppinger, T., Cortis, C., D'Haese, S., De Craemer, M., Di Blasio, A., Hansen, S., Iacoviello, L., Issartel, J., Izzicupo, P., Jaeschke, L., Kanning, M., Ling, F.C.M., Luzak, A., Napolitano, G., Nazare, J-A., Perchoux, C., Pischon, T., Polito, A., Sannella, A., Schulz, H., Sohun, R., Steinbrecher, A., Schlicht, W., MacDonncha, C., Capranica, L., and Boccia, S.

Abstract

Background To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course. Methods Medline, Embase, ISI Web of Science, Scopus and SPORTDiscus were searched for systematic literature reviews and meta-analyses of observational studies investigating the association between socioeconomic determinants of PA and PA itself (from January 2004 to September 2017). Data extraction evaluated the importance of determinants, strength of evidence, and methodological quality of the selected papers. The full protocol is available from PROSPERO (PROSPERO2014:CRD42015010616). Results Nineteen reviews were included. Moderate methodological quality emerged. For adults, convincing evidence supports a relationship between PA and socioeconomic status (SES), especially in relation to leisure time (positive relationship) and occupational PA (negative relationship). Conversely, no association between PA and SES or parental SES was found for pre-school, school-aged children and adolescents. Conclusions Available evidence on the socioeconomic determinants of PA behaviour across the life course is probable (shows fairly consistent associations) at best. While some evidence is available for adults, less was available for youth. This is mainly due to a limited quantity of primary studies, weak research designs and lack of accuracy in the PA and SES assessment methods employed. Further PA domain specific studies using longitudinal design and clear m

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