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1. Mismatch repair deficiency in bilateral breast cancer

Author

Milena Massumi Kozonoe, Jacqueline Justino Nabhen, Bruno Ribeiro Batista, Lucas Novello, Edenir Inêz Palmero, Sérgio Ossamu Ioshii, and Júlia Costa Linhares

Subjects
Breast cancer, Bilateral breast cancer, Microsatellite instability, Mismatch repair deficiency, Mutational load, Immunotherapy, Surgery, RD1-811, Pathology, RB1-214
Abstract

Abstract Background Since the FDA approved immune-enhancing therapies for patients with high microsatellite instability (MSI-H) and/or mismatch repair deficiency (dMMR), recognizing these biomarkers in solid tumors has gained clinical importance. Although MSI-H and dMMR are considered uncommon in breast cancer, previous studies on bilateral breast cancer (biBC) identified a surprisingly high frequency of MSI. Methods In this study, we aimed to describe the prevalence of dMMR and its association with clinicopathologic parameters in biBC. We performed immunohistochemistry with anti-MMR proteins on tissue microarrays (TMAs) with 58 bilateral breast cancer cases. The biomarkers used were MLH1, PMS2, MSH2, MSH6, ER, PR, HER2 and Ki67. SPSS was used for data analysis. Results Four (6.9%) cases showed dMMR on TMAs. Three (75%) of the dMMR cases were luminal and one (25%) was triple negative. Two biBC cases presented unilateral dMMR. No association between dMMR status and clinicopathologic parameters was found. Conclusions This work highlights a noticeable frequency of dMMR in bilateral breast cancer and builds upon previous research in this area, suggesting routine MMR protein testing as part of the immunohistochemical panel for biBC to identify candidates for immune-enhancing therapies.

Published
2024
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2. Tumor de Células Granulares em Mama Apresentando-se como Nódulo BI-RADS 5 à Ultrassonografia: Relato de Caso

Author

Juliane Soldi Malgarin, Sérgio Augusto Mayer, Julia Wolff Barretto, Júlia Costa Linhares, Ana Paula Martins Sebastião, and Samya Hamad Mehanna

Subjects
Neoplasias da Mama/epidemiologia, Tumor de Células Granulares/epidemiologia, Patologia, Saúde da Mulher, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Introdução: O tumor de células granulares (TCG) é uma neoplasia rara e predominantemente benigna, frequentemente localizada na região da cabeça e pescoço. Comumente, afeta adultos entre 40 e 60 anos, com maior incidência em mulheres. O TCG mamário, representando de 5% a 15% de todos os TCG, demanda diagnóstico histopatológico em virtude de semelhanças clínicas e radiológicas com malignidades mamárias. Tipicamente, manifesta-se como massa solitária palpável, embora a multicentricidade ocorra em até 20% dos casos, seja em tumores mamários ou de outros sítios. Relato do caso: Paciente, 43 anos, com nódulo hipoecoico classificado como BI-RADS 5 na ultrassonografia, localizado no quadrante superolateral da mama esquerda, às duas horas, de formato irregular, medindo 7,0 x 6,0 mm nos maiores eixos e distando 50 mm da papila. Por ser radiologicamente suspeito, foi realizada a core biopsy mamária, que microscopicamente foi categorizada como lesão de potencial maligno incerto. A análise imuno-histoquímica revelou positividade para S100 e CD68, indicando origem em células de Schwann, associada à negatividade para citoqueratinas e receptores hormonais, desfavorecendo a origem epitelial dos carcinomas. A conduta terapêutica foi a exérese cirúrgica completa do nódulo, e a análise histopatológica confirmou tratar-se de TCG. Conclusão: Relatar essa neoplasia faz-se importante em razão da raridade da condição e sua capacidade de mimetizar cânceres mamários.

Published
2024
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3. Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) is a UDP-dependent galactosyltransferase

Author

João B. Vicente, Ana Catarina L. Guerreiro, Beatriz Felgueiras, Digantkumar Chapla, Daniel Tehrani, Kelley W. Moremen, and Júlia Costa

Subjects
Medicine, Science
Abstract

Abstract Glycosyltransferases (GTs) are enzymes that catalyze the formation of glycosidic bonds and hundreds of GTs have been identified so far in humans. Glycosyltransferase 8 domain-containing protein 1 (GLT8D1) has been associated with central nervous system diseases and cancer. However, evidence on its enzymatic properties, including its substrates, has been scarcely described. In this paper, we have produced and purified recombinant secretory GLT8D1. The enzyme was found to be N-glycosylated. Differential scanning fluorimetry was employed to analyze the stabilization of GLT8D1 by Mn2+ and nucleotides, revealing UDP as the most stabilizing nucleotide scaffold. GLT8D1 displayed glycosyltransferase activity from UDP-galactose onto N-acetylgalactosamine but with a low efficiency. Modeling of the structure revealed similarities with other GT-A fold enzymes in CAZy family GT8 and glycosyltransferases in other families with galactosyl-, glucosyl-, and xylosyltransferase activities, each with retaining catalytic mechanisms. Our study provides novel structural and functional insights into the properties of GLT8D1 with implications in pathological processes.

Published
2023
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4. Recommendations for reproducibility of cerebrospinal fluid extracellular vesicle studies

Author

Ursula S. Sandau, Setty M. Magaña, Júlia Costa, John P. Nolan, Tsuneya Ikezu, Laura J. Vella, Hannah K. Jackson, Lissette Retana Moreira, Paola Loreto Palacio, Andrew F. Hill, Joseph F. Quinn, Kendall R. Van Keuren‐Jensen, Trevor J. McFarland, Joanna Palade, Eric A. Sribnick, Huaqi Su, Kostas Vekrellis, Beth Coyle, You Yang, Juan M. Falcón‐Perez, Rienk Nieuwland, Julie A. Saugstad, and International Society for Extracellular Vesicles Cerebrospinal Fluid Task Force

Subjects
biomarkers, brain, central nervous system, cerebrospinal fluid, exosome, extracellular vesicle, Cytology, QH573-671
Abstract

Abstract Cerebrospinal fluid (CSF) is a clear, transparent fluid derived from blood plasma that protects the brain and spinal cord against mechanical shock, provides buoyancy, clears metabolic waste and transports extracellular components to remote sites in the brain. Given its contact with the brain and the spinal cord, CSF is the most informative biofluid for studies of the central nervous system (CNS). In addition to other components, CSF contains extracellular vesicles (EVs) that carry bioactive cargoes (e.g., lipids, nucleic acids, proteins), and that can have biological functions within and beyond the CNS. Thus, CSF EVs likely serve as both mediators of and contributors to communication in the CNS. Accordingly, their potential as biomarkers for CNS diseases has stimulated much excitement for and attention to CSF EV research. However, studies on CSF EVs present unique challenges relative to EV studies in other biofluids, including the invasive nature of CSF collection, limited CSF volumes and the low numbers of EVs in CSF as compared to plasma. Here, the objectives of the International Society for Extracellular Vesicles CSF Task Force are to promote the reproducibility of CSF EV studies by providing current reporting and best practices, and recommendations and reporting guidelines, for CSF EV studies. To accomplish this, we created and distributed a world‐wide survey to ISEV members to assess methods considered ‘best practices’ for CSF EVs, then performed a detailed literature review for CSF EV publications that was used to curate methods and resources. Based on responses to the survey and curated information from publications, the CSF Task Force herein provides recommendations and reporting guidelines to promote the reproducibility of CSF EV studies in seven domains: (i) CSF Collection, Processing, and Storage; (ii) CSF EV Separation/Concentration; (iii) CSF EV Size and Number Measurements; (iv) CSF EV Protein Studies; (v) CSF EV RNA Studies; (vi) CSF EV Omics Studies and (vii) CSF EV Functional Studies.

Published
2024
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5. A análise jurídica da educação sexual de crianças e adolescentes

Author

Júlia Costa

Subjects
Sexualidade, Direitos humanos, Direito à Educação Sexual, Infância e Juventude, Jurisprudence. Philosophy and theory of law, K201-487, Political institutions and public administration (General), JF20-2112
Abstract

O presente trabalho, com procedimento baseado em pesquisas bibliográficas e documentais, tem como objetivo discutir a existência de um direito humano de educação sexual a crianças e adolescentes, com observância à premissa de que a sexualidade é uma característica inata ao ser humano desde seu nascimento. Constatada a relevância conferida aos direitos humanos e fundamentais pela Constituição Federal de 1988, bem como contemplando o direito à educação como um direito social, passa-se a análise de existência e de delimitação de um direito à educação sexual garantido à criança e ao adolescente, de modo pleno e que propicie o saudável desenvolvimento. Assim, constata-se a existência de um direito à educação sexual que, assegurado pelo sistema jurídico brasileiro, deve ser garantido pela família, sociedade e Estado, fins de pleno desenvolvimento da pessoa humana.

Published
2023

6. Suicídio e povos indígenas brasileiros: revisão sistemática

Author

Ronaldo Santhiago Bonfim de Souza, Júlia Costa de Oliveira, Juliana Alvares-Teodoro, and Maycoln Leôni Martins Teodoro

Subjects
população indígena, suicídio, revisão sistemática, brasil, Medicine, Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

Objetivo. Descrever a frequência, as características e os fatores que contribuem para o suicídio em povos indígenas brasileiros. Método. Foi realizada uma revisão sistemática da literatura a partir das bases de dados PubMed, SciELO, PsycINFO e LILACS. Foram incluídos estudos de base populacional que enfocassem suicídio em populações indígenas no território brasileiro. Resultados. A busca identificou 111 artigos, dos quais nove preencheram os critérios de inclusão. Três estudos foram realizados na região Centro-Oeste, quatro na região Norte do Brasil e dois abordaram todas as regiões do Brasil. Três estudos citaram as etnias estudadas, totalizando sete etnias (Terena, Kadiweu, Guato, Ofaie-Xavante, Guarani, Guarani-Kaiowá e Guarani-Nandeva). Os estudos demonstraram maior taxa de mortalidade por suicídio em pessoas do sexo masculino, solteiros, com 4 a 11 anos de escolaridade, na faixa etária de 15 a 24 anos, no domicílio e nos finais de semana, tendo como principal método o enforcamento. Os principais fatores de risco para o suicídio foram pobreza, fatores históricos e culturais, baixos indicadores de bem estar, desintegração das famílias, vulnerabilidade social e falta de sentido de vida e futuro. Conclusões. Todos os estudos indicaram a necessidade de desenvolvimento de estratégias em conjunto com as comunidades, considerando sua cosmovisão e os aspectos sócio-histórico-culturais de cada etnia, para minimização dos fatores de risco e redução da taxa de suicídio.

Published
2020
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7. P2X7 Receptor Triggers Lysosomal Leakage Through Calcium Mobilization in a Mechanism Dependent on Pannexin-1 Hemichannels

Author

Stephanie Alexia Cristina Silva Santos, Pedro Muanis Persechini, Bianca Monteiro Henriques-Santos, Victória Gabriela Bello-Santos, Newton G. Castro, Júlia Costa de Sousa, Fernando Ariel Genta, Marcelo Felippe Santiago, Robson Coutinho-Silva, Luiz Eduardo Baggio Savio, and Eleonora Kurtenbach

Subjects
lysosomes, P2 receptor, cathepsins, extracellular ATP, lysosomal permeabilization, Immunologic diseases. Allergy, RC581-607
Abstract

The P2X7 receptor is a critical purinergic receptor in immune cells. Its activation was associated with cathepsin release into macrophage cytosol, suggesting its involvement in lysosomal membrane permeabilization (LMP) and leakage. Nevertheless, the mechanisms by which P2X7 receptor activation induces LMP and leakage are unclear. This study investigated cellular mechanisms associated with endosomal and lysosomal leakage triggered by P2X7 receptor activation. We found that ATP at 500 μM and 5 mM (but not 50 μM) induced LMP in non-stimulated peritoneal macrophages. This effect was not observed in P2X7-deficient or A740003-pretreated macrophages. We found that the P2X7 receptor and pannexin-1 channels mediate calcium influx that might be important for activating specific ion channels (TRPM2 and two-pore channels) on the membranes of late endosomes and lysosomes leading to LMP leakage and consequent cathepsin release. These findings suggest the critical role of the P2X7 receptor in inflammatory and infectious diseases via lysosomal dysfunction.

Published
2022
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8. Insect Cells for High-Yield Production of SARS-CoV-2 Spike Protein: Building a Virosome-Based COVID-19 Vaccine Candidate

Author

Bárbara Fernandes, Rute Castro, Farien Bhoelan, Denzel Bemelman, Ricardo A. Gomes, Júlia Costa, Patrícia Gomes-Alves, Toon Stegmann, Mario Amacker, Paula M. Alves, Sylvain Fleury, and António Roldão

Subjects
IC-BEVS, spike protein, virosomes, protein production, Pharmacy and materia medica, RS1-441
Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) homotrimeric spike (S) protein is responsible for mediating host cell entry by binding to the angiotensin-converting enzyme 2 (ACE2) receptor, thus being a key viral antigen to target in a coronavirus disease 19 (COVID-19) vaccine. Despite the availability of COVID-19 vaccines, low vaccine coverage as well as unvaccinated and immune compromised subjects are contributing to the emergence of SARS-CoV-2 variants of concern. Therefore, continued development of novel and/or updated vaccines is essential for protecting against such new variants. In this study, we developed a scalable bioprocess using the insect cells-baculovirus expression vector system (IC-BEVS) to produce high-quality S protein, stabilized in its pre-fusion conformation, for inclusion in a virosome-based COVID-19 vaccine candidate. By exploring different bioprocess engineering strategies (i.e., signal peptides, baculovirus transfer vectors, cell lines, infection strategies and formulation buffers), we were able to obtain ~4 mg/L of purified S protein, which, to the best of our knowledge, is the highest value achieved to date using insect cells. In addition, the insect cell-derived S protein exhibited glycan processing similar to mammalian cells and mid-term stability upon storage (up to 90 days at −80 and 4 °C or after 5 freeze-thaw cycles). Noteworthy, antigenicity of S protein, either as single antigen or displayed on the surface of virosomes, was confirmed by ELISA, with binding of ACE2 receptor, pan-SARS antibody CR3022 and neutralizing antibodies to the various epitope clusters on the S protein. Binding capacity was also maintained on virosomes-S stored at 4 °C for 1 month. This work demonstrates the potential of using IC-BEVS to produce the highly glycosylated and complex S protein, without compromising its integrity and antigenicity, to be included in a virosome-based COVID-19 vaccine candidate.

Published
2022
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9. Responsabilidade contratual e extracontratual, uni-vos? Comentários ao Recurso Especial n. 1.281.594/SP

Author

Júlia Costa de Oliveira

Subjects
Law, Civil law, K623-968
Abstract

Buchalla Veículos Ltda. (“Autora” ou “Buchalla”) ajuizou ação ordinária contra Ford Motor Company Brasil Ltda. (“Ford” ou “Ré”) pleiteando reparação de danos decorrentes de alegado inadimplemento contratual da Ré. Segundo a Autora, a Ford teria inobservado seus direitos de exclusividade e preferência para comercialização da marca Ford na região de Presidente Prudente, além de descumprir o “Plano de Ação do Distribuidor”.

Published
2018

10. Cerebrospinal Fluid Chitinases as Biomarkers for Amyotrophic Lateral Sclerosis

Author

Júlia Costa, Marta Gromicho, Ana Pronto-Laborinho, Conceição Almeida, Ricardo A. Gomes, Ana C. L. Guerreiro, Abel Oliva, Susana Pinto, and Mamede de Carvalho

Subjects
amyotrophic lateral sclerosis, chitinases, cerebrospinal fluid, biomarkers, Medicine (General), R5-920
Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative neuromuscular disease that affects motor neurons controlling voluntary muscles. Survival is usually 2–5 years after onset, and death occurs due to respiratory failure. The identification of biomarkers would be very useful to help in disease diagnosis and for patient stratification based on, e.g., progression rate, with implications in therapeutic trials. Neurofilaments constitute already-promising markers for ALS and, recently, chitinases have emerged as novel marker targets for the disease. Here, we investigated cerebrospinal fluid (CSF) chitinases as potential markers for ALS. Chitotriosidase (CHIT1), chitinase-3-like protein 1 (CHI3L1), chitinase-3-like protein 2 (CHI3L2) and the benchmark marker phosphoneurofilament heavy chain (pNFH) were quantified by an enzyme-linked immunosorbent assay (ELISA) from the CSF of 34 ALS patients and 24 control patients with other neurological diseases. CSF was also analyzed by UHPLC-mass spectrometry. All three chitinases, as well as pNFH, were found to correlate with disease progression rate. Furthermore, CHIT1 was elevated in ALS patients with high diagnostic performance, as was pNFH. On the other hand, CHIT1 correlated with forced vital capacity (FVC). The three chitinases correlated with pNFH, indicating a relation between degeneration and neuroinflammation. In conclusion, our results supported the value of CHIT1 as a diagnostic and progression rate biomarker, and its potential as respiratory function marker. The results opened novel perspectives to explore chitinases as biomarkers and their functional relevance in ALS.

Published
2021
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11. Construção de um Instrumento para Avaliar o Uso de Bebidas Alcóolicas em uma Etnia Indígena de Minas Gerais

Author

Ronaldo Santhiago Bonfim de Souza, Júlia Costa de Oliveira, and Maycoln Leôni Martins Teodoro

Subjects
Health Evaluation, Alcoholism, Indigenous Population, Psychology, BF1-990
Abstract

Resumo O uso abusivo de bebidas alcoólicas é um grave problema de saúde pública em indígenas brasileiros. O objetivo deste estudo foi desenvolver uma entrevista de avaliação que entendesse a frequência do uso e os prejuízos do álcool nessas comunidades, e utilizá-la em uma avaliação inicial. Tal entrevista de avaliação foi desenvolvido a partir de uma revisão sistemática de instrumentos já utilizados nacional e internacionalmente. No estudo piloto, seis lideranças indígenas foram avaliadas por entrevistas individuais, que foram submetidas à análise de conteúdo e categorização das respostas. Dos indígenas avaliados, todos relataram ter consumido bebida alcoólica, três apresentaram comportamentos de beber muito e dois reconheceram a necessidade de buscar tratamento para seu consumo de bebida. Os resultados encontrados demonstram ser possível avançar na avaliação do uso de álcool em indígenas no Brasil. O aperfeiçoamento da avaliação desenvolvida possibilitará a elaboração de projetos de intervenção adequados para o enfrentamento do abuso de álcool nas comunidades indígenas. A Psicologia, de forma técnica e ética, deve estar presente nessa problemática, cara às necessidades biopsicossociais dessas populações.

Published
2019
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13. Human carboxylesterase 2: Studies on the role of glycosylation for enzymatic activity

Author

Márcia Alves, Joana Lamego, Tiago Bandeiras, Rute Castro, Hélio Tomás, Ana Sofia Coroadinha, Júlia Costa, and Ana Luisa Simplício

Subjects
Carboxylesterase, Deglycosylation, Glycosylation, hCES, Site directed mutagenesis, Biology (General), QH301-705.5, Biochemistry, QD415-436
Abstract

Human carboxylesterase 2 (hCES2) is a glycoprotein involved in the metabolism of drugs and several environmental xenobiotics, whose crystallization has been proved to be a challenging task. This limitation could partly be due to glycosylation heterogeneity and has delayed the disclosure of the 3D structure of hCES2 which would be of upmost relevance for the development of new substrates and inhibitors. The present work evaluated the involvement of glycans in hCES2 activity and thermo stability in an attempt to find alternative active forms of the enzyme that might be adequate for structure elucidation. Partial or non-glycosylated forms of a secreted form of hCES2 have been obtained by three approaches: (i) enzymatic deglycosylation with peptide N-glycosidase F; (ii) incubation with the inhibitor tunicamycin; ii) site directed mutagenesis of each or both N-glycosylation sites. Deglycosylated protein did not show a detectable decrease in enzyme activity. On the other hand, tunicamycin led to decreased levels of secreted hCES2 but the enzyme was still active. In agreement, mutation of each and both N-glycosylation sites led to decreased levels of secreted active hCES2. However, the thermostability of the glycosylation mutants was decreased. The results indicated that glycans are involved, to some extent in protein folding in vivo, however, removal of glycans does not abrogate the activity of secreted hCES2.

Published
2016
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14. Práticas colaborativas em redes agroecológicas no agreste pernambucano

Author

Pedro Castelo Branco Silveira and Júlia Costa Rosas

Subjects
Colaboração, conhecimentos tradicionais, agroecologia, propriedade intelectual, caatinga, Anthropology, GN1-890, Ethnology. Social and cultural anthropology, GN301-674
Abstract

Este artigo aborda as contribuições das redes agroecológicas para os debates sobre o acesso aos conhecimentos tradicionais. O material empírico que trazemos é o de pesquisa no agreste pernambucano, sobre as redes de produção de conhecimento de que fazem parte agricultores que desenvolvem práticas agroecológicas. Neste campo, agricultores e organizações de assessoria estão envolvidos em uma série de experiências que se baseiam na incorporação de conhecimentos dos agricultores, de técnicos e em testes e experimentos, não necessariamente em bases científicas, de novas práticas agrícolas. O pano de fundo destas experiências é o fortalecimento de propostas ecopolíticas conhecidas como “convivência com o Semiárido” que se afastam de pacotes tecnológicos e se aproximam de modos criativos e colaborativos de praticar conhecimentos.

Published
2018
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15. The Montaigne’s Essays bilingual subject

Author

Gilson Ramos Lopes Neto, Júlia Costa Mendes, and Isabella Mozzillo

Subjects
Bilinguismo, Montaigne, Os Ensaios., Philology. Linguistics, P1-1091, French literature - Italian literature - Spanish literature - Portuguese literature, PQ1-3999
Abstract

The Lord of Montaigne is positioned positively to the practice of bilingualism in his post-Renaissance’s Essays. Based on the contemporary literature of Languages in Contact, this paper proposes a dialogue between an excerpt of this masterpiece and myths and beliefs related to the individual bilingual. Thus, it is suggested that the plurilinguism predominates instead of monolingualism since the Fifteenth Century.

Published
2017

16. Clinical and surgical therapeutic approach in Erithema Elevatum Diutinum - case report

Author

Luciana Helena Zacaron, Júlia Costa de Faria Gonçalves, Vanessa Maria Amoreira Curty, Antonio Macedo D'Acri, Ricardo Barbosa Lima, and Carlos José Martins

Subjects
Dapsone, Erythema, Vasculitis, Dermatology, RL1-803
Abstract

Erythema elevatum diutinum is a rare chronic cutaneous vasculitis which usually affects adults. It is characterized by symmetrical and persistent papules, plaques, and nodules. These lesions are usually located on the extensor surfaces of the extremities. We report a case of erythema elevatum diutinum in which the association of dapsone and surgical excision promoted complete remission of skin lesions, providing a new approach to the treatments described in the literature.

Published
2013
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17. Quando a morte visita a maternidade: atenção psicológica durante a perda perinatal

Author

Júlia Costa Muza, Erica Nascimento de Sousa, Alessandra da Rocha Arrais, and Vera Iaconelli

Subjects
Psychology, BF1-990
Abstract

Este estudio se basó en una metodología cualitativa con el objetivo de co- nocer el significado de la pérdida perinatal para familias en luto y evaluar la intervención psicológica en situaciones de luto perinatal. Participaron del estudio cinco familias que experimentaron las muertes perinatales en una maternidad Brasília. Se utilizaron como instrumentos el registro psicológico de la psicología de la maternidad y una entrevista de evaluación después de ocurrir el óbito. Del análisis de Bardin (1977), surgieron cinco categorías, a saber: la historia del embarazo, padres antes de la muerte de su hijo, el deseo de reparar, adiós bebé y la evaluación del servicio de la psicología de la situación de duelo. Los resultados demostraron que el trabajo psicológico intensivo de luto sufri- do por las familias todavía recibe poco apoyo de las instituciones sociales y la psicología de la salud, no obstante es un trabajo que puede desempeñar un papel clave a lo largo de estas familias con el fin de prevenir el trauma futuro, para evitar el duelo patológico y los embarazos correctivas.

Published
2013

19. Sialoglycoproteins and N-glycans from secreted exosomes of ovarian carcinoma cells.

Author

Cristina Escrevente, Nicolas Grammel, Sebastian Kandzia, Johannes Zeiser, Erin M Tranfield, Harald S Conradt, and Júlia Costa

Subjects
Medicine, Science
Abstract

Exosomes consist of vesicles that are secreted by several human cells, including tumor cells and neurons, and they are found in several biological fluids. Exosomes have characteristic protein and lipid composition, however, the results concerning glycoprotein composition and glycosylation are scarce. Here, protein glycosylation of exosomes from ovarian carcinoma SKOV3 cells has been studied by lectin blotting, NP-HPLC analysis of 2-aminobenzamide labeled glycans and mass spectrometry. An abundant sialoglycoprotein was found enriched in exosomes and it was identified by peptide mass fingerprinting and immunoblot as the galectin-3-binding protein (LGALS3BP). Exosomes were found to contain predominantly complex glycans of the di-, tri-, and tetraantennary type with or without proximal fucose and also high mannose glycans. Diantennary glycans containing bisecting N-acetylglucosamine were also detected. This work provides detailed information about glycoprotein and N-glycan composition of exosomes from ovarian cancer cells, furthermore it opens novel perspectives to further explore the functional role of glycans in the biology of exosomes.

Published
2013
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27. Agronomic and environmental implications of using a By-Product of the Intermediate Tanning Processes as Nitrogen Fertilizer

Author

Silvia Maria de Oliveira-Longatti, Marcele Gabriel Cannata, Júlia Costa Ferrazani, Teotonio Soares de Carvalho, Claudio Ciavatta, and Luiz Roberto Guimarães Guilherme

Subjects
high-Mn soils, agronomic efficiency, trivalent chromium, hexavalent chromium, microbiological parameters, Agriculture (General), S1-972
Abstract

ABSTRACT Nitrogen (N) is an important nutrient for agriculture, and Brazil is heavily dependent on N imports. A by-product of the intermediate processes of tanning (BPIPT) may be used as an N fertilizer which will reduce this dependency, but its chromium (Cr) content is a matter of concern. This work assessed Cr (III, VI) and N (total, inorganic) contents in four soil samples with contrasting characteristics (especially with respect to their content of manganese (Mn), a potential Cr(III) oxidant), following the addition of the BPIPT. Chemical and microbiological indicators of soil quality were measured to assess the agronomic and environmental implications of the BPIPT addition in Brazilian soils. Our results indicate that the BPIPT is a promising source of N. The originally available Mn content in the soil did not influence the effect of the BPIPT on soil Cr(VI) content. Finally, microbial activity was generally stimulated after BPIPT addition to the soil. This information is relevant because: 1) it shows that the beneficial use of the BPIPT as an N fertilizer is important for adding value to a by-product with agronomic potential; and 2) it indicates that, at the dosage of the BPIPT used in this study (2.5 g kgsoil−1), the typical increases in the soil concentration of labile Cr (0–25 mg kgsoil−1) and Cr(VI) (0–0.8 mg kgsoil−1) due to the application of the BPIPT are not detrimental to biological activity in the soil. However, further investigations are still necessary to evaluate the mobility of these Cr species in the soil and possible risks of groundwater contamination, which were not addressed in this study.

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28. SARAMPO E SAÚDE PÚBLICA: PANORAMA ATUAL E REEMERGÊNCIA

Author

NUNES, FERNANDO GOMES, primary, OLIVEIRA, ARLEN MACHADO DE, additional, GOMES, ANA JÚLIA COSTA MATIAS, additional, SANTOS, DANIEL CARLOS DOS, additional, COSTA FILHO, REGIVALDO RODRIGUES DA, additional, SOARES, ERIKA DOS SANTOS, additional, RIZZI, LEONARDO NUNES ESTRADA, additional, SANDES NETO, JOÃO, additional, VASCONCELOS, CLARA ARANTES, additional, MARTINS, FERNANDA FRANCO, additional, BOCHINI, LARISSA LORRAINE MEIADO, additional, BRITO, GUILHERME AUGUSTO MONTEIRO, additional, STEIN, BRUNO EDUARDO PESSOA DE FREITAS, additional, SILVA, ENDY SOUZA, additional, and SILVA FILHO, DANIEL RODRIGUES, additional

Published
2022
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29. ALTERNATIVAS PARA O REJUVENESCIMENTO PERIOCULAR: NEUROMODULADORES DE TOXINA BOTULÍNICA A, PREENCHIMENTOS DÉRMICOS DE ÁCIDO HIALURÔNICO E RADIOFREQUÊNCIA

Author

MACEDO, ANA JÚLIA BASSO, primary, COUTO, CAMILA BARROS, additional, AMARAL, BIANCA AZEVEDO BERGER, additional, COUTO, LORENA BARROS, additional, ARAUJO, JÚLIA COSTA DE, additional, PORCELLI, KEROL MARTINIANO, additional, BRANDÃO, JOANA BADER SADALA, additional, MARQUES, CAROLINA CRONEMBERGER CRUZ, additional, CONCEIÇÃO, EDUARDA ALMEIDA DUTRA DA, additional, GOMES, ANA JULIA, additional, ESPÍNOLA, MARIA TEREZA DE MEDEIROS LEITE, additional, and FLORIDO NETO, JOSÉ SEPULVEDA, additional

Published
2022
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30. VANTAGENS DA ABORDAGEM MULTIDISCIPLINAR NA HUMANIZAÇÃO DA GRAVIDEZ E DO PARTO

Author

Lopes, Júlia Costa, primary, Motta, Helena Amédée Péret, additional, Sales, Isabela Gomes, additional, Dornelas, Júlia Abreu, additional, Couto, Luíza Camargos, additional, Avelar, Maria Clara Martins, additional, Mariquito, Maria Fernanda Abritta, additional, Bernardes, Vitória, additional, Mesquita Neto, Carlos Antônio, additional, Pimenta, Luiza Ferreira, additional, Costa, Thaynara França, additional, and Leite, Mariana Godoy, additional

Published
2022
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32. DOMÍNIO DA LÍNGUA INGLESA PARA A CARREIRA MÉDICA.

Author

Silva Ferraz, Jade, e Silva, Júlia Costa, Soares, Lívia, and Vieira Viana, Nicolas Gabriel

Subjects
ENGLISH language, LABOR market, COMMUNICATIVE competence, INTERNATIONAL markets, LINGUISTIC context
Abstract

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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34. ANÁLISES DA INFLUÊNCIA DOS COMPRIMENTOS E PROPORÇÕES DE FIBRAS DO BAGAÇO DE CANA DE AÇÚCAR NA RESISTÊNCIA À TRAÇÃO DOS COMPÓSITOS

Author

Fernandes, Thamina Iris Rendeiro, primary, Santos, Dèborah Júlia Costa Dos, additional, Vianna, Alexandre Garcia Wanderley Coelho, additional, Brandão, Luis Felipe Alencar, additional, Estumano, Diego Cardoso, additional, Rodrigues, Emerson Cardoso, additional, and Costa, Deibson Silva da, additional

Published
2024
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36. COMPÓSITOS POLIMÉRICOS COM FIBRAS DO BAGAÇO DA CANA-DE-AÇÚCAR: INFLUÊNCIA DO COMPRIMENTO NAS PROPRIEDADES FÍSICAS E MECÂNICA

Author

Lima, Maria Eduarda Pacheco de, primary, Santos, Dèborah Júlia Costa Dos, additional, Fernandes, Thamina Iris Rendeiro, additional, Dias, Andreza Karen Brioso, additional, Brandão, Luis Felipe Alencar, additional, Estumano, Diego Cardoso, additional, Rodrigues, Emerson Cardoso, additional, and Costa, Deibson Silva da, additional

Published
2024
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37. IMPACTO PSICOSSOCIAL NA POPULAÇÃO IDOSA MEDIANTE A COVID-19

Author

Leite, Maria Thereza de Freitas, primary, Araújo, Géssica Barros, additional, Melo, Giovanna Gomes Bezerra, additional, Freitas, Júlia Marques de, additional, Silva, Laura Queiroz, additional, Aguiar, Lucas Bezerra de, additional, Moura, Maria Júlia Costa Pinheiro de, additional, Abrantes, Maely Moreira de, additional, Santos, Mylena Beatriz Alves dos, additional, Cesar, Rafaela Ramalho, additional, Bezerra, Rafael de Freitas, additional, and Freitas, Hélita Bezerra, additional

Published
2021
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38. SAÚDE MENTAL - VOLUME 2

Author

Lana, Eduardo Horta Seabra, primary, Vasconcelos, Ana Rosa Reis, additional, Barbosa, Camila Stéfani De Oliveira, additional, Barbosa, Gabriel Guimarães, additional, Melo, Giovanna Prata Silva, additional, Martins, Julia Maria Campos, additional, Ramos, Luísa Santiago, additional, Luz, Rita De Cássia Porenna Nascimento, additional, Dias, Josimar Kapps de Souza, additional, Bastos, Ana Carolina da Silva, additional, Rocha, Ana Paula, additional, Barcellos, Camila, additional, Côgo, Estêvan Calvi, additional, COSTELLA, GISELI, additional, Pereira, Guilherme H J, additional, Moraes, Leonardo Peres, additional, Costa, Luiza Gabriela, additional, Oliveira, Maurycia Lima De, additional, Fronza, Murilo Elias, additional, Ridel, Patrícia Gabriela, additional, Mello, Rafaela da Silva Vieira de, additional, Assis, Isadora Ferolla Fiuza De, additional, Milagre, Cláudia Cristine Silva, additional, Ribeiro, Fabrícia Gabrielle Gonçalo, additional, Figueiredo, Felipe Bernardes Nascimento, additional, Figueiredo, Júlia Bernardes Nascimento, additional, Oliveira, Antônio Carlos, additional, Rodrigues, Rosely Valéria, additional, Andrade, Christopher Harrison Salomão, additional, Lima, Israel Carlos Cavalcanti De, additional, Marques, Vitor Marcelo Frez, additional, Oliveira, Wilyan Dias Cosmo De, additional, Araújo, Wudson Henrique Alves De, additional, Canella, Douglas Alves Da Costa, additional, Menezes, Gabriela Rodrigues De, additional, Silva, Gerlaine Damasceno, additional, Vizioli, Bruna, additional, Leite, Igor de Almeida Balduino, additional, Dias, Andressa Maciel, additional, Andrade, Vinicius Oliveira De, additional, Fonseca, Marcos Matheus da Silva, additional, Pires, Antônio Lourenço, additional, Costa, Mara J M, additional, Lima, Sarah Beatriz Rocha, additional, Nogueir, Marcela Araújo Sá, additional, Lins, Raphaela da Penha, additional, Segundo, Manoel Pedro De Farias, additional, Silva, Ronaldo de Ataide Nicácio, additional, Oliveira, Nathália Lopes De, additional, Santos, Nadilly Sobral Monteiro Dos, additional, Passos, Evelyn Amorim Dias, additional, Silva, Ellen Dayanne Barros, additional, Melo, Guilherme Silva De, additional, Rodrigues, Priscylla Frazão, additional, Fonseca, Olívio Joaquim, additional, Barbosa, João Victor Carvalho, additional, Ferraz, Isabella Cabral, additional, Lima, Cláudio Vinícius Barroso Queirós de, additional, Souza, Pedro Henrique De, additional, RIBEIRO, DANIELLA DE LOURDES BAGGIO REHFELD, additional, RODRIGUES, EMANUELA CARVALHO, additional, BOAVENTURA, JÚLIA VELOSO, additional, PEREIRA, LUÍSA BAMBIRRA, additional, SADER, LUÍSA MACHADO CAMPOLINA, additional, RODRIGUES, MARIANNE NETO, additional, FERREIRA, SOFIA GONÇALVES, additional, SCHERRER, ISABELA RESENDE SILVA, additional, Pagnan, Ana Júlia, additional, Galdino, Roberto, additional, Soares, Elidivane Martins De Freitas, additional, Moura, Caroline Farias Barreto De, additional, Almeida, Cynthia Von Paumgartten Ribeiro, additional, Lima, Isabelle Girão De Oliveira, additional, Feitosa, Júlia Albuquerque, additional, Macedo, Laiane De Alencar, additional, Severiano, Marina Oliveira, additional, Oliveira, Viviane De Sousa, additional, Moraes, Gerídice Lorna Andrade, additional, Brito, Marcela Cirino de, additional, Freitas, Ana Paula Goulart de, additional, Alves, Lucas Ferreira, additional, Costa, Matheus Torres Dutra Maia da, additional, Oliveira, Mellina Mendes de, additional, Lino, Maria Clara Miranda, additional, Bruno, Camila Guimarães Pimenta, additional, Miranda, Lincoln De Castro, additional, Radd, Luis Gustavo Amaral, additional, Assunção, Luíza Israel Silva, additional, Marques, Marcus Vinícius Capobiango, additional, Resende, Maria Eduarda Evangelista, additional, Pereira, Rubens Maciel Martins, additional, Oliveira, Weaver Santos, additional, Bernardes, Maria Eduarda Cunha, additional, Rodrigues, Thais Martins De Oliveira, additional, Campos, Lucas Machado, additional, Perillo, Júlia De Oliveira, additional, Baraky, Marcelle De Castro, additional, Costa, Thais Siqueira, additional, Cardoso, Renata Araújo, additional, Souza, Allan Maia Andrade de, additional, Soares, Laila Fontan, additional, Torres, Larissa Frazão, additional, Moreira, Marina Gonzaga, additional, Souza, Gianfranco Rizzotto de, additional, Rocha, Neusa Sica da, additional, Drumond, Ana Paula Diniz Gonçalves, additional, Araújo, Gabriela Sampaio Lima, additional, Domingos, Maria Mariana Aguiar, additional, Arruda, Hahnemann Silveira, additional, Soares, Giovanna Cunha, additional, Medeiros, Ingrid Silva, additional, Costa, Gildean Pereira, additional, Silva, João Pedro Oliveira Da, additional, Araújo, Lídia Souza, additional, Branco, July Grassiely De Oliveira, additional, Silva, Gabriella Gonçalves Boato Da, additional, Soares, Samantha Alves, additional, Costa, Francisca Bertilia Chaves, additional, Sousa, André Luiz Rodrigues Soares, additional, Silva, Juliana Guimarães E, additional, Lopes, Laressa B, additional, Carvalho, Amanda Salles, additional, Assis, Camila Carolina Alves, additional, Silva, Guilherme Leão Da, additional, Brito, João Carlos Inácio De Carvalho, additional, Morato, Juliana B, additional, Silva, Kevyn Willian Luz, additional, Martins, Ludmila V, additional, Garcia, Saulo De Moraes, additional, Yusuf, Said Nimir Mohamed Nimir, additional, Barbosa, Marcelo Eduardo Ramos, additional, Ribeiro, Camilla Forlin Pereira Erthal, additional, Teixeira, Eduardo Campos, additional, Farias, Euller Reis, additional, Carvalho, Larissa Scarpini De, additional, Ruette, Rafaela Silva Lagazzi, additional, Ciancaglio, Júlio Cesar Bredas, additional, Teixeira, Eduardo Henrique, additional, Santos, João Victor Fagundes Dos, additional, Vaz, Alan Flávio Ramos Teixeira, additional, Siegel, Alexandre Weirich Meurer, additional, Angeli, Bianca De Marco, additional, Costa, Gabriel Antônio Simões, additional, Calil, Iara Pinheiro, additional, Veloso, João Pedro Donato, additional, Freitas, Luciano Gonzaga E, additional, Jardim, Mateus Cândido Diniz, additional, Silva, Matheus Fernandes Costa E, additional, Leão, Rafael Augusto De Carvalho, additional, Sad, Victor Goulart, additional, Sidrim, Gustavo Henrique Silva, additional, Freitas, Melissa Oliveira, additional, Lima, Tiago Ker E, additional, Silva, Isa Beatriz Alves, additional, Lima, Gabriela Rigueira Angelo De, additional, Silva, Kathiany Scarlaty Rodrigues, additional, Moreira, Frederico Bernardo Sapori, additional, Lucas, Carolina Oliveira, additional, Lala, João Victor Cançado, additional, Coelho, Roberta Cíntia Sousa, additional, Coelho, Luiza Rocha Pinto, additional, Vilela, Thiago De Moraes, additional, CARVALHO, LUANA IZABELA AZEVEDO DE, additional, Galvão, Ana Carolina Souza, additional, Galvão, Virgínia Souza, additional, Carvalho, Luana Izabela Azevedo De, additional, BIASON, GIOVANNA GUIMARÃES, additional, ALVES, THAYNARA CASTELO DE LIMA, additional, FUJIMOTO, VICTÓRIA CRISTINA MENDONÇA, additional, Loiola, Elissandra Ferreira, additional, Gonçalves, Ana Carolina Miranda, additional, Costa, Beatriz Campos, additional, Silvestre, Iasmine Pereira Ribeiro De Sena, additional, Azevedo, João Victor Bezerra De Moura, additional, Oliveira, Lara Carvalho De, additional, Santos, Sabrina Messias De Almeida, additional, Liandro, Camila Raydan, additional, Canuto, Anna Leticia Pereira, additional, Mesquita, Daniella Guelman, additional, Oliveira, Danyella Fernanda De Sá, additional, Santos, Ludmilla Rodrigues De Souza Mol, additional, Peixoto, Lívia Granero, additional, Ferraresso, Carolina Kobbaz, additional, Monteiro, Gabriel de Oliveira, additional, Silva, Luis Augusto Batista da, additional, Moraes, Mariana Ribeiro, additional, Viana, Matheus Santos, additional, Artoni, Rafael Cambraia, additional, Rocha, Tales Vilela, additional, Tanquella, Francini Spillere, additional, CORDEIRO, JÚLIA COUTINHO, additional, AMARAL, MARIELA SVÍZZERO, additional, Frota, Elizabeth Regina Comini, additional, Gleitzmann, Hannah Bryskier, additional, Rissi, Anna Cecília Silveira, additional, Pinto, Gustavo Martins Fioravante, additional, Martins, Stephanie Pascoal Miranda, additional, Mendes, Vanessa Do Rosario Costa, additional, Martiniano, Francisca G S, additional, Silva, Celina J C, additional, Souza, Karolayne Silva, additional, Araújo, Kaiane Bastos, additional, Pereira, Francisco Jeferson Pontes, additional, Santos, Edineuma Oliveira Dos, additional, Gusmão, Rízia Kelly Da Silva, additional, Palitot, Alan Cássio Morais, additional, Vasconcelos, Anailda Fontenele, additional, Sousa, Elane Cristina Fernandes Lima, additional, Barros, Marcia Do Nascimento, additional, Medeiros, Matheus Ribeiro De, additional, Reis, Fabiana De Andrade, additional, Lima, Fabrício Gabriel Freitas, additional, Sousa, Rayssa Da Silva, additional, Martins, Samuel Bezerra Magalhães, additional, Vidal, David Barbosa Duarte, additional, Melo, Lucas Rodrigues, additional, Santos, Gabriel Sousa, additional, Oliveira, Marcus Vinícius Macedo, additional, Gondim, João Pedro Lima, additional, Matos, Jonathan Moreira Silva De, additional, Lima, Mateus Coelho Gondim De Oliveira, additional, Melo, Larissa Rodrigues, additional, Martins, Renato Mendes, additional, Gomes, Mateus Miguel De Sousa, additional, Oliveira, Fernanda Caetano Solano, additional, Castro, Henrique Ulisses Duarte De, additional, Mendes, Matheus Fortunato, additional, Brommonschenkel, Alexandre De Castro, additional, Ferreira, Sheila Martins, additional, Carvalho, Ana Luísa Bravieira, additional, Nunes, Beatriz Carnevalli, additional, Fonseca, Letícia Ferreira da, additional, Menegucci, Luis Guilherme Ferreira, additional, Freire, Renata Correia, additional, Ferreira, Rafael Sousa Araújo, additional, Melo, Carlos Gonzaga, additional, Carneiro, Aurelice Cristina De Almeida Alves, additional, Leite, José Márcio Soares, additional, Ramalho, Rayssa Carolline, additional, Oliveira, Breno Diniz, additional, Oliveira, Júlia Costa De, additional, Moura, Patrícia Guerra, additional, Silveira, Fernanda Santi, additional, Oliveira, Tauane da Mata Vieira, additional, Benevides, Lucas Silveira, additional, Pinheiro, Caroline Dourado, additional, Prudente, Ana Luiza Naves, additional, Morales, Bruna Almeida, additional, Garrote, Celso Henrique Denófrio, additional, Andrade, Gabriela Couto, additional, Silvério, Natália Ribeiro, additional, and Musmanno, Luiz Henrique Fernandes, additional

Published
2021
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39. COVID-19 - O VÍRUS QUE MOVIMENTOU A CIÊNCIA - VOLUME 1

Author

Almeida, Priscilla Dantas, primary, Araújo, Telma Maria Evangelista de, additional, Brandão, Socorro Adriane de S Meneses, additional, SENA, INARA VIVIANE DE OLIVEIRA, additional, Rodrigues, Érica De Alencar, additional, COSTA, JOELMA MARIA, additional, FRONTEIRA, INÊS, additional, CARDOSO, JONAS ALVES, additional, MELO, EUGÊNIO BARBOSA DE, additional, ALMEIDA, MALENA GONÇALVES, additional, Oliveira, Amanda de Sousa, additional, Silva, Brenda Gonçalves da, additional, Amaro, Cristiane Pereira da Silva, additional, Sousa, Eugenia Gabrielly Alves, additional, Oliveira, Maria Luzia Borges de, additional, Sousa, Rosiane Almeida, additional, Almeida, Sabrina Gomes, additional, FALAVINA, LARISSA PEREIRA, additional, LENTSKC, MAICON HENRIQUE, additional, BARATIERI, TATIANE, additional, PITILIN, ERICA DE BRITO, additional, SANGATELI, CARINE TELES, additional, FUJIMORI, ELIZABETH, additional, Souza, Victor Vinícius da Cruz, additional, Vicentini, Helene Dantas Lima, additional, Mesquita, Leticia de Paula, additional, Sandes, Thayssa Souza, additional, Oliveira, Giovanna Borba, additional, GALDINO, NAYARA DA SILVA, additional, Peixoto, Lucas Cunha, additional, Nascimento, Isabella Moraes do, additional, Melo, Raiana Rodrigues Costa, additional, Abrantes, Maely Moreira de, additional, Gadelha, Lara Rachel Palmeira de Araújo, additional, Silva, Laura Queiroz, additional, Moura, Maria Júlia Costa Pinheiro de, additional, Leandro, Rhévia Mara de Figueiredo, additional, Silva, Thalita de Sá Lira Braga e, additional, Maia, Vivian Maria, additional, Silva, Cleyton Cézar Souto, additional, Menezes, João Daniel de Souza, additional, Mota, Maria Eduarda Dóro, additional, Brandão, Vânia Zaqueu, additional, Ribas, João Luiz Coelho, additional, BARAN, BRUNA APARECIDA, additional, Cunha, Ana Clara Lemos Andrade, additional, Leitão, Rhayssa Vasconcelos, additional, Moura, Scarlat Marjory de Oliveira, additional, FONTOURA, MURILO BARBOZA, additional, FONTOURA, MAÍZA BARBOZA, additional, Iúdice, Tirça Naiara da Silva, additional, Carvalho, Adalberto Cerqueira de, additional, Pereira, Bruno Alberto Falcão, additional, Vieira, Arthemis Soares, additional, Belota, Luiz Henrique Abreu, additional, TELES, SAMUEL GOMES DA SILVA, additional, CASTRO, MARIA CECÍLIA SIMÕES RISCADO DE, additional, DUTRA, SABRINA NOGUEIRA, additional, SANTOS, LÍDIA MÁRCIA SILVA, additional, MORAES, BRUNA DE MOURA, additional, INNOCENTE, MARIA LAURA BRUNELLI, additional, Brito, Patrícia Leite, additional, Rocha, Carolina Luzia Barcelos, additional, Melo, Pedro Resgalla Guimarães de, additional, Faria, Thiago Gonçalves, additional, PEREIRA, JULIANA TOMÉ, additional, Santos, Anna Clara Oliveira, additional, Gomes, Mariana Santos, additional, Morais, Savanna Almeida De, additional, Alves, Jessica Elen Martins, additional, Zica, Mariana Barbosa, additional, Santos, Daniel Spósito, additional, Oliveira, Cecília Soares de, additional, Silva, Ana Cláudia Zuba da, additional, Ornelas, Maria Elisa Souza, additional, Passos, Jessyka Cardoso dos, additional, Teixeira, João Fleury, additional, Rodrigues, Emilly Bruna Soares, additional, Pereira, Breno Magno Gomes, additional, Alves, Felipe Giordano Matos Menezes, additional, Lucena, Gabriel Albuquerque de, additional, Martins, Helman Fernando Paraguay, additional, Carneiro, Júlia Helena Faustino, additional, Silva, Luiz Eduardo Gondim, additional, Fialho, Nathalia Maria Menezes, additional, Viana, Renan Baracuhy Cruz, additional, Wanderley, Saulo, additional, Lacerda, Valdécio Vasconcelos, additional, Marques, Vanessa Julinda Ribeiro Coutinho, additional, ROCHA, ANDRÉ SOUSA, additional, LIMA, VERINEIDA SOUSA, additional, SOUSA, VITÓRIA TALYA DOS SANTOS, additional, RIBEIRO, ANA CARLA NOBRE, additional, DAMASCENO, MONIK CAVALCANTE, additional, SOUSA, ZILDENILSON DA SILVA, additional, ALVES, CHARLES PHILLIPE DE LUCENA, additional, Almeida, Rafaella Farias da Franca, additional, Ferreira, Amanda Emanuela Machado, additional, MATOS, Lucas Vasconcelos da Silva, additional, Ramos, Carlos Antônio Mariz, additional, Torres, Matheus Coelho, additional, Toni, Leonardo Pereira, additional, Bianca, Pedro Arthur Gonçalves de Medeiros Dela, additional, Queiroz, Camila Jales Lima de, additional, Medeiros, Ewerton Freitas de, additional, Castro, Luana Fernandes Da Silva Oliveira, additional, Costa, Maria Júlia Ribeiro da, additional, Santos, Geovanna Godinho, additional, Fernandes, Fernanda Rodrigues Mangabeira, additional, Geronasso, Vitoria Fossari, additional, Costa, Giovanna de Carvalho Meneses, additional, Pitanga, Lorena Sipauba, additional, Trajano, João Gualda Garrido, additional, Caselato, Maria Letícia Lopes Mol, additional, Kreitchmann, Péres, additional, Pedro, Caroline de Oliveira, additional, Goes, Atena Saito, additional, Silva, Amanda Lazaro e, additional, Marti, Giovanna Chiavegatti de Castro Fagan, additional, Castelli, Gustavo Pereira Junqueira, additional, Ivanaga, Hendrick Yuji, additional, Endo, Hugo Emérico Yutaka, additional, Santos, Isabela Cristina Moreira, additional, Melo, Maria Júlia P, additional, Dias, Maria Luisa Alexandrino, additional, SILVA, BARBARA BEATRIZ LIRA DA, additional, ALVES, ANA KLARA RODRIGUES, additional, PEREIRA, RAQUEL DE BRITO, additional, ALVES, ANA KAMILA RODRIGUES, additional, NOGUEIRA, FÁBIO DIAS, additional, RODRIGUES, RICARDO VIEIRA BEZERRA LUZ, additional, RODRIGUES, SANDRA LUIZA GOUVÊA, additional, SANTO, JALES GOMES ESPÍRITO, additional, NOGUEIRA, FLÁVIA DIAS, additional, ALVES, ANA KARLA RODRIGUES, additional, Reiff, Laura Magalhães, additional, Reiff, Cláudio de Castro, additional, Hespanhol, Cecília Barra de Oliveira, additional, Silveira, Sophia Calábria da, additional, Detogni, Giovanna, additional, Moreira, Fernanda Franklin Pedroso, additional, Vieira, Juliana Domith de Oliveira, additional, Leite, Marcela Goreske, additional, Figueiredo, Pollyanny Lilian, additional, Lima, Amilto Mendes, additional, Andrade, Matheus Gomes, additional, Siqueira, Nágela Bezerra, additional, Pereira, Lurdiane Gabriel, additional, Pereira, Maria Larysse Muniz, additional, Camelo, Paula Alves, additional, Alves, Mikaelly Teixeira, additional, Silva, Felicia Maria Rodrigues da, additional, Sousa, José Fernando Martins, additional, Melo, Dilene Fontinele Catunda, additional, Cunha, Maria da Conceição dos Santos Oliveira, additional, CORREIA, ELISA DE CASTRO, additional, CASTRO, ANA BEATRIZ SAMPAIO PINTO DE, additional, LIMA, TATIANA MONTANDON LASSI LOPES, additional, SILVA, HELLEN CAROLINA BRANDÃO, additional, BICALHO, GABRIELA BOLLER, additional, BERNIS, EDUARDA HERINGER, additional, BARBOSA, JOÃO ARTHUR RODRIGUES, additional, AZEVEDO, INGRIDY MARIA DINIZ MELO, additional, BICHARA, MATHEUS MIRANDA, additional, OLIVEIRA, RAYANA VIEGAS, additional, Albuquerque, Lidiane Pereira de, additional, Rêgo, Otávio Augusto Nunes do, additional, Sousa, Sarah Batista de, additional, Araújo, Regina Maria Sousa de, additional, Araújo, Vitória Gabriele Barros de, additional, Sales, Liandra Vírginia de Sousa Coêlho, additional, Silva, Bárbara Leite da, additional, Barrinha, Maria Clara Falcão, additional, Silva, Verônica Letícia Magalhães da, additional, Almeida, Rumana de França, additional, Melo, Ingrid da Silva, additional, Rocha, Amanda Virginia Teles, additional, Moraes, Ramires dos Santos, additional, Alves, Nágila Silva, additional, CARVALHO, NAYARA ALMEIDA, additional, OLIVEIRA, THAYENE BARBOSA DE, additional, QUISTE, SARAH SOUZA, additional, TEIXEIRA, BEATRIZ NASSER, additional, CUNHA, JORDANA CARNEIRO RODRIGUES DA, additional, OLIVEIRA, MORGANA ROCHA COUTINHO DE, additional, MITTELMANN, IARA CAROLINI, additional, SANTOS, ANDRÉ REHBEIN, additional, SALES, PRISCILA MAGALHÃES ESTEVES DE, additional, BORGES, RAQUEL CAMARGOS, additional, Mafra, Caio Souza Lima, additional, Chaimowicz, Beatriz de Faria, additional, Menezes, Bruno Petrocchi Vieira de, additional, Villela, Ana Carolina Wegmann, additional, Coutinho, Camila Hostalacio Duarte, additional, Santos, Clara Chagas Barbosa, additional, Pimenta, Clara Rubião, additional, Silva, Daniela Diniz Martins da, additional, Fonseca, David Bastos Vieira da, additional, Valadares, Nara Maria Meira, additional, FRANCO, DANIELLA RIBAS, additional, MORILA, MARIANA CRISTINA GOMES, additional, FONSECA, LUCAS AUGUSTO NIESS SOARES, additional, MESQUITA, FRANCIELLE BIANCA MOREIRA DE, additional, LESSA, RUAN TEIXEIRA, additional, MORATO, PEDRO CÉSAR, additional, VIDAL, DAVI MARTINS, additional, SOUZA, DANILO JOSÉ MARTINS DE, additional, Ferreira, Tayná Beato, additional, Silva, Vitória Leite, additional, Batista, Galileu Bitencourt, additional, Mendes, Nathália Barbosa do Espírito Santo, additional, Faria, Thaís Guimarães de, additional, Pereira, Gabriella Reis Granata, additional, Pizani, Izabella Alves, additional, Ferreira, Julia Caramatti, additional, Almeida, Luiza Figueiredo Ribeiro, additional, Gama, Henrique Valladão Pires, additional, Passos, Ovídio Neves Berquó de, additional, Rocha, João Gabriel Seixo de Britto, additional, Lima, Laura Araújo de, additional, Trigueiro, Gustavo Machado, additional, Fernandes, Caroline Ferreira, additional, Uesugi, Juliana Hiromi Emin, additional, Silva, Jonatan Carlos Cardoso da, additional, Trindade, Eliane Leite da, additional, SOUZA, CAIO FERREIRA FILGUEIRAS DE, additional, REIS, BRUNA ELISA SANTIAGO, additional, CASTRO, CÁSSIA LUANA DE FARIA, additional, NASCIMENTO, EDUARDA FARIA DO, additional, FACCIO, CAROLINA BOHN, additional, MANSUR, HELENA MARTINS FERREIRA, additional, MANSUR, ISABELA MARTINS FERREIRA, additional, FULBER, JADE GUIMARÃES, additional, FERRAZ, JOÃO PEDRO KREMER, additional, BINKOWSKI, LUDMILA LIMPIAS TERRAZAS, additional, VAZ, VINICIUS CATTO, additional, CARUSO, FERNANDA BORSATTO, additional, Silva, Marcos Paulo Da, additional, Lourenço, Heitor Fernandes, additional, Neves, Gabriela Gonçalves Saraiva, additional, Amorim, Davi Candido, additional, Gomes, Antônio Caio Carvalho, additional, LIMA, JOSÉ AILTON GOMES DE, additional, Silva, Nathália Paula Da, additional, Sousa, Zildenilson da Silva, additional, Silva, Thaylon Menezes Ferreira da, additional, Pereira, João Ricardo Gomes, additional, Rodrigues, Shara Teixeira Belarmino, additional, Freitas, Marcelo Matos de, additional, Rodrigues, José Auberlanio Lima, additional, Sousa, Jady Júlia Patrício de, additional, Cipriano, Antônio Marcos Adriano, additional, Silva, Natália Viviane de Freitas da, additional, Rocha, André Sousa, additional, Nóbrega, Ianny Costa Moura de Paiva, additional, Souza, Khívio Dantas de Assis, additional, Araújo, Roberta Letícia Paiva de, additional, Ribeiro, Brenda de Souza, additional, BEZERRA, MICHELLY FERNANDES, additional, Silva, Letícia Figueirôa, additional, RABELO, MARINA ARAÚJO, additional, SANTOS, AMANDA SIMÕES, additional, GONÇALVES, ANA PAULA MENDONÇA, additional, FREIRE, MARINA VILLELA, additional, RODRIGUES, PEDRO AUGUSTO SCHREIER, additional, SILVA, JOSÉ DIAS, additional, NORONHA, NATHALIA COSTA MACEDO, additional, PASSOS, ANDRÉ LUÍS FERREIRA DE SOUZA, additional, CRUZ, ISABELLE SILVA MELO DA, additional, RAMOS, MARIA LETÍCIA CARVALHO DA CRUZ, additional, SOARES, MARIANA DA COSTA CAMPOS, additional, LESSA, VERÔNICA VIRGÍNIA SANTOS, additional, MAYNARD, LUANA GODINHO, additional, GUIMARAES, THIAGO ALBUQUERQUE DE MENEZES, additional, ROCHA, GABRIEL, additional, CHATEAUBRIAND, GUILHERME TEIXEIRA, additional, LACERDA, JULIA SCOTTI GONÇALVES, additional, FERREIRA, PEDRO CHAVES, additional, LEITE, PITHER PAUL SILVA, additional, SOUZA, RAYNER GUILHERME DE, additional, PIRES, RICARDO LAGE GUERRA LOTT, additional, GONÇALVES, SAMUEL CRISTOVAO LOPES, additional, PITANGUI, SERVULO WALLNER, additional, SARAIVA, JAYANE MENDES, additional, CARVALHO, LUMA MATOS, additional, SOUSA, LETÍCIA LUDWIG, additional, CAIXETA, LETÍCIA MARIA, additional, MARQUES, SÍLVIA FERNANDA PEREIRA, additional, MARQUES, IZE AMANDA PEREIRA, additional, SOUSA, KESSIA VITORIA SILVA, additional, MACHADO, MARÍLLIA DE FREITAS, additional, CAMPOS, BRUNA TAFURI LOBATO, additional, COELHO, BÁRBARA GISELLY ZANON, additional, BRANDÃO, TOMÁS ELAWAR SILVIANO, additional, VILAÇA, GABRIELLE SILVEIRA, additional, ASSIS, VIVIAN COSTA MORAIS DE, additional, SANTOS, JEHOVAHNNA ANTTONIONI, additional, SPÓSITO, LAVÍNIA ARRUDA, additional, Pinheiro, Elisama Pereira, additional, MORAL, LORENA RAMOS, additional, PONTES, KAIO HENRIQUE OLIVEIRA, additional, Batista, Matheus Neres, additional, S, Joel A, additional, OLIVEIRA, MARCELA MARINHO DE, additional, Veloso, Eliana A N, additional, OLIVEIRA, CAIO LIMA, additional, LIMA, LUCAS EMMANUEL RODRIGUES DE, additional, LIMA, LUANA BEATRIZ RIBEIRO, additional, SOARES, ANA CATARINA TOMAZ, additional, BARDOTTI, ARIANNA, additional, SANTOS, ALICE FREIRE DOS, additional, SILVA, BIANCA DO NASCIMENTO, additional, ANDRADE, LARYSSA ELLEN MOURA DE, additional, ARNEZ, TICIANA MEDEIROS DE SABOIA, additional, ALMEIDA, LAURA F DE, additional, MOURÃO, ANA C S, additional, WERNECK, BEATRIZ M, additional, DIAS, DIEGO B, additional, MATTA, GUSTAVO P, additional, REIS, IOLY G DOS, additional, PRETA, MARIA P S C, additional, JACOMETTI, VICTOR, additional, CORREA, VICTOR L F, additional, REZENDE, VITORIA F, additional, Oliveira, Halley Ferraro, additional, CARRANZA, BRENDA LOUISE PRADO, additional, SILVEIRA, FERNANDA BEATRIZ SANTOS, additional, GOMES, ZULEIDE BARROS LUNA, additional, CARVALHO, KETTINY FERNANDA N DE, additional, AGUIAR, GUSTAVO ALVES, additional, ANTUNES, SABRINA BARRETO, additional, MONTE, KAHENA MONTEIRO ALMEIDA, additional, SANTANA, BÁRBARA REIS DE, additional, Souza, Júllia Beatriz Araujo, additional, Santos, João Marcos da Cunha, additional, Coelho, Larissa Maria Prado, additional, Rebouças, Natália Quiroga, additional, ANDRADE, PEDRO VÍTOR PASSOS DA COSTA, additional, Araújo, Wesley Vinicius Tenório de, additional, OLIVEIRA, HALLEY FERRARO, additional, Duz, Bruna, additional, Curi, Julio Soares, additional, FORTUNA, TIAGO, additional, ROVERSI, CAROLINE DE OLIVEIRA, additional, LOPES, LUIZ ROBERTO, additional, Nascimento, Isabella Moraes, additional, SCHWENING, SARAH SOUZA QUISTE, additional, and Paiva, Ianny Costa Moura de, additional

Published
2021
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42. MANEJO PÓS PARADA CARDÍACA E PREVENÇÃO DE DESFECHOS NEGATIVOS: O QUE FALAM OS ESTUDOS MAIS RECENTES

Author

Oliveira, Ana Virgínia Oliveira Brito e, primary, Cruz, Daniella Gomes, additional, Viana, Jéssica Sheller Pereira, additional, Furtado, Larissa Júlia Costa, additional, Azevedo, Luana Menezes, additional, Lopes, Lucas de Araujo, additional, Gonçalves, Maria Beatriz Neves, additional, Gomes, Maria Clara Nonato Soares, additional, Vieira, Matheus Gomes, additional, and Figueiredo, Naiara Oliveira, additional

Published
2021
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43. INFARTO AGUDO DO MIOCÁRDIO NA GESTAÇÃO: PREVENÇÃO, DIAGNÓSTICO E MANEJO ADEQUADO

Author

Oliveira, Ana Virgínia Oliveira Brito e, primary, Cruz, Daniella Gomes, additional, Viana, Jéssica Sheller Pereira, additional, Furtado, Larissa Júlia Costa, additional, Azevedo, Luana Menezes, additional, Lopes, Lucas de Araujo, additional, Gonçalves, Maria Beatriz Neves, additional, Gomes, Maria Clara Nonato Soares, additional, Vieira, Matheus Gomes, additional, and Figueiredo, Naiara Oliveira, additional

Published
2021
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44. Análise associativa entre hipertensão e ansiedade

Author

De Oliveira, Arlen Machado, primary, Albernaz, Yuri Faria, additional, Tolentino, Sicília Gabriella Gonçalves, additional, Nunes, Fernando Gomes, additional, Gomes, Ana Júlia Costa Matias, additional, Dos Santos, Ramila Barbosa Ferreira, additional, Cavalcante, Thiago Arruda Prado, additional, and Silva Filho, Daniel Rodrigues, additional

Published
2023
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45. Introdução à emergência do pronto socorro

Author

Palhares, Felipe Campanatti, primary, Gomes, Ana Carolina Bastos e, additional, Gasparotto, Ana Letícia Sínico, additional, Júnior, Adilson de Oliveira Ferreira, additional, Ferreira, Júlia Costa Lima, additional, Torrente, Natally Macedo, additional, and Rosado, Giovanna de Paula, additional

Published
2023
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50. COVID-19 e seus efeitos no sistema cardiovascular

Author

Ruan Martins Bonzi, Igor Rocha de Miranda Ferreira, Breno Henrique Ferreira, Priscilla Francielle de Souza, Júlia Costa de Oliveira, Victor Hugo Esteves Teixeira, Vitoria Rocha Amaral, and Mariana de Paula Dias

Subjects
Marketing, Pharmacology, Organizational Behavior and Human Resource Management, Strategy and Management, Drug Discovery, Pharmaceutical Science
Abstract

O SARS-CoV-2 é um vírus RNA de fita simples, pertencente à subclasse beta dos Coronavírus.Este vírus apresenta ampla capacidade de mutação e recombinação rápida, e despertou a atenção do mundo em dezembro de 2019, com o alarmante número de casos em Wuhan, na China, e, desde março de 2020, causou o alerta mundial quando a ONU declarou a COVID-19, infecção a ele associada, uma pandemia global.MÉTODOS: Foi realizada uma revisão bibliográfica integrativa usando os descritores covid-19, SARS-CoV-2, hipercoagulação edoenças cardiovascularesnos últimos 2 anos em base de dados como Medline, Lilacs, Scielo e UpToDate. RESULTADOS: Essa busca resultou em 15 artigos para elaboração dessa revisão. CONCLUSÃO:O efeito cardiovascular pode ser fruto de lesão direta à célula miocárdica pela própria patogenia viral e pode ser também de maneira indireta através dos efeitos sistêmicos da ‘tempestade inflamatória’; além disso o efeito inflamatório leva a um estado pró-trombótico que, junto ao aumento do estresse do cisalhamento sanguíneo devido ao maior aporte sanguíneo ao coração, pode fazer com que haja ruptura de placa aterosclerótica, tendo como última consequência o infarto agudo do miocárdio. Por fim, é preciso considerar, também, que a própria terapêutica da doença emprega medicamentos que podem levar a danos no sistema cardiovascular e, não menos importante, o processo infeccioso pode levar a desequilíbrio eletrolítico que pode gerar distúrbios cardiovasculares, como por exemplo a hipocalemia, que pode acarretar em arritmia.

Published
2022
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