1. Sleep Problems Are Related to a Worse Quality of Life and a Greater Non-Motor Symptoms Burden in Parkinson's Disease
- Author
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J García Caldentey, Nuria Caballol, Pablo Mir, Lluís Planellas, I Cabo López, Lydia Vela, E Suárez Castro, L. López Manzanares, C Cores Bartolomé, J.C. Martínez Castrillo, J González Ardura, J G Muñoz Enriquez, J M Paz González, J Ruíz Martínez, N López Ariztegui, M I Gastón, J. Pagonabarraga, Diego Santos-García, T de Deus Fonticoba, M J Catalán, Jaime Kulisevsky, C Valero, Carlos Prieto, M J Feal Panceiras, Esther Cubo, M Seijo, M Álvarez Sauco, M G Alonso Losada, P Sánchez Alonso, I. Legarda, Monica M. Kurtis, Víctor Nogueira, Pablo Martinez-Martin, M A Ávila Rivera, and C Borrué
- Subjects
Sleep Wake Disorders ,Quality of life ,medicine.medical_specialty ,Parkinson's disease ,Parkinson's disease sleep scale ,Non-motor symptoms ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Quality of life (healthcare) ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,sleep ,business.industry ,Parkinson Disease ,medicine.disease ,Sleep in non-human animals ,non-motor symptoms ,Parkinson´s disease ,Large cohort ,Psychiatry and Mental health ,Cross-Sectional Studies ,quality of life ,Non motor ,Neurology (clinical) ,Geriatrics and Gerontology ,Sleep ,business ,Parkinson´s disease sleep scale ,030217 neurology & neurosurgery - Abstract
COPPADIS Study Group., [Introduction] The aim of the present study was to examine the frequency of self-reported sleep problems and their associated factors in a large cohort of PD patients., [Methods] PD patients and controls, recruited from 35 centers of Spain from the COPPADIS cohort were included in this cross-sectional study. Sleep problems were assessed by the Spanish version of the Parkinson’s disease Sleep Scale version 1 (PDSS-1). An overall score below 82 or a score below 5 on at least 1 item was defined as sleep problems., [Results] The frequency of sleep problems was nearly double in PD patients compared to controls: 65.8% (448/681) vs 33.5% (65/206) (p < 0.0001). Mean total PDSS score was lower in PD patients than controls: 114.9 ± 28.8 vs 132.8 ± 16.3 (p < 0.0001). Quality of life (QoL) was worse in PD patients with sleep problems compared to those without: PDQ-39SI, 19.3 ± 14 vs 13 ± 11.6 (p < 0.0001); EUROHIS-QoL8, 3.7 ± 0.5 vs 3.9 ± 0.5 (p < 0.0001). Non-motor symptoms burden (NMSS; OR = 1.029; 95%CI 1.015–1.043; p < 0.0001) and impulse control behaviors (QUIP-RS; OR = 1.054; 95%CI 1.009–1.101; p = 0.018) were associated with sleep problems after adjustment for age, gender, disease duration, daily equivalent levodopa dose, H&Y, UPDRS-III, UPDRS-IV, PD-CRS, BDI-II, NPI, VAS-Pain, VAFS, FOGQ, and total number of non-antiparkinsonian treatments., [Conclusion] Sleep problems were frequent in PD patients and were related to both a worse QoL and a greater non-motor symptoms burden in PD. These findings call for increased awareness of sleep problems in PD patients.
- Published
- 2021