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2. Chronic enteroviral meningoencephalitis in agammaglobulinemia: case report and literature review

Author

G. P. Spickett, H.M. Chapel, E. R. Moxon, J. B. Kurtz, C. Sherwood, Siraj A. Misbah, J. S. Kroll, J. M. Hockaday, and P. C. J. Ryba

Subjects
Male, Echovirus, Immunology, Acyclovir, Echovirus Infections, medicine.disease_cause, Immunoglobulin E, chemistry.chemical_compound, Agammaglobulinemia, Meningoencephalitis, hemic and lymphatic diseases, Immunopathology, Ribavirin, medicine, Immunology and Allergy, Humans, biology, business.industry, Immunoglobulins, Intravenous, medicine.disease, chemistry, Child, Preschool, biology.protein, Enterovirus, Antibody, Complication, business
Abstract

Chronic enteroviral meningoencephalitis is a well-recognized complication in patients with X-linked agammaglobulinemia (XLA). The majority of published cases refers to its occurrence in patients on no replacement therapy or on only intramuscular immunoglobulin. The advent of intravenous immunoglobulin (IVIg) in the early 1980s and its widespread use in XLA was thought to have virtually eradicated enteroviral meningoencephalitis in these patients. We describe the development of echovirus meningoencephalitis in an 11-year-old boy on regular IVIg replacement whose serum IgG levels were maintained at between 6 and 8 g/L (NR 6-13 g/L). Treatment with daily high-dose IVIg was commenced, with significant clinical improvement being noted within a few weeks in association with a reduction in blood-brain barrier permeability. The persistence of live virus, however, necessitated the use of intraventricular immunoglobulin. The virus proved resistant to two courses of specific intraventricular immunoglobulin and a 6-week course of oral ribavirin and eventually proved fatal 5 months after presentation. In view of the therapeutic uncertainties we have reviewed the use of immunoglobulin in the treatment of enteroviral meningoencephalitis over the past 6 years.

Published
1992

3. Prospective comparison of modified-fat–high-carbohydrate with standard low-carbohydrate dietary advice in the treatment of diabetes: one year follow-up study

Author

R. C. Turner, Jim Mann, J. M. Hockaday, and T. D. R. Hockaday

Subjects
Adult, Blood Glucose, medicine.medical_specialty, Time Factors, High carbohydrate, One year follow up, Medicine (miscellaneous), Physiology, law.invention, Randomized controlled trial, law, Diabetes mellitus, Diabetes Mellitus, Dietary Carbohydrates, medicine, Humans, Prospective Studies, Prospective cohort study, Low carbohydrate, Triglycerides, Aged, Nutrition and Dietetics, business.industry, Body Weight, Middle Aged, medicine.disease, Dietary advice, Dietary Fats, Clinical trial, Cholesterol, Physical therapy, business
Abstract

1. A prospective randomized study of two dietary regimens has been started in newly-diagnosed diabetics to determine their effect on circulating metabolites and on diabetic complications.2. During the first year of treatment the fasting plasma glucose concentrations on both the low-carbohydrate diet and the high-carbohydrate, modified-fat (MF) diet showed a similar decrease.3. Plasma cholesterol showed a sustained decrease only in patients recommended a MF diet. Transient changes in plasma triglyceride concentrations occurred in patients on both dietary regimens.4. Increased plasma cholesterol levels are associated with atheromatous disease which is common in diabetics in Europe and North America. A MF diet may therefore have an advantage in that it lowers the plasma cholesterol as well as being effective in lowering the plasma glucose.

Published
1978
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4. Tenth Annual Meeting of the European Association for the Study of Diabetes

Author

K. G. M. M. Alberti, J. Iversen, N. J. Christensen, A. Andersson, Claire Jarrousse, Arne Andersson, Claes Hellerström, D. Andreani, G. Tamburrano, S. Tamburrano, S. Gambardella, Joy Ardill, D. A. D. Montgomery, D. R. Hadden, R. Assan, J. R. Attali, A. Selmi, N. Bourdillat, E. Soufflet, J. R. Girard, J. S. Bajaj, G. S. Chinna, S. K. Garg, Baldev Singh, E. O. Balasse, M. A. Neef, W. Beischer, F. Melani, L. Keller, M. Hinz, A. Kroder, V. Maier, E. F. Pfeiffer, M. Bendayan, E. Sandborn, E. Rasio, D. Bensoussan, S. Levy-Toledano, P. Passa, J. Caen, M. Berger, M. N. Goodman, S. A. Hagg, N. B. Ruderman, J. Beyer, U. Cordes, H. Travniczek, W. Heider, K. Schöffling, J. Happ, H. Grimm, W. Pünchera, P. H. Althoff, A. Fröhlich, A. R. Bianco, R. H. Schwartz, B. S. Handwerger, P. J. Blackshear, P. A. H. Holloway, D. H. Williamson, L. Boquist, Bo Hellman, Åke Lernmark, Inge-Bert Täljedabl, P. Bottermann, U. Schweigart, Th. Zilker, W. Hansen, E. Brachet, C. Rogister, Y. Broer, P. Freychet, G. Rosselin, H. Brunengraber, F. Vertongen, M. Boutry, F. Camu, P. Christacopoulos, B. Karamanos, P. Papadimitriou, Ch. Kardatos, Niels Juel Christensen, Bent Neubauer, Jean Christophe, Jacques Winand, Jean Dehaye, G. S. Cuendet, E. G. Loten, B. Jeanrenaud, E. Davis, Ralph E. Yodaiken, L. Yanko, J. B. Herman, S. Duran Garcia, C. Jarrousse, J. Ditzel, Niels Peters Daugaard, Haakon Andersen, J. Egeberg, J. Nerup, O. O. Andersen, H. Kromann, G. Bendixen, J. E. Poulsen, E. Eschwege, S. Falkmer, S. O. Emdin, N. Havu, L. Winbladh Biuw, F. Sundby, J. F. Cutfield, S. M. Cutfield, G. G. Dodson, J. D. Peterson, D. F. Steiner, F. Fallucca, G. Menzinger, M. Iavicoli, G. Federspil, C. de Palo, E. Zago, D. Casara, M. Zaccaria, C. Scandellari, J. -P. Felber, G. Magnenat, B. Curchod, Ph. Pittet, N. Lytras, R. Müller-Hess, C. A. Geser, E. Jéquier, R. W. J. Flanagan, K. D. Buchanan, R. F. Murphy, Ivar Fölling, M. Fromantin, J. Freyria, F. Bressac, W. Geisthövel, U. Niedergerke, K. D. Morgner, B. Willms, H. J. Mitzkat, K. F. Gey, E. Bühler, P. Sommer, H. Georgi, H. Lengsfeld, D. Ghiea, E. Costiner, L. Simionescu, M. Oprescu, V. Grill, E. Cerasi, H. J. G. Gundersen, A. Gutman, J. Adler, D. Bar-Or, A. Gutzeit, B. Guy-Grand, B. Bigorie, Erik Gylfe, Lars-Åke Idahl, Margit Hamosh, Paul Hamosh, Adrian Hart, H. Cohen, J. M. Thorp, C. J. Hedeskov, K. Capito, B. Forruby, J. C. Henquin, A. B. Lambert, A. E. Lambert, K. D. Hepp, R. Renner, H. U. Häring, H. Mehnert, W. Kemmler, G. Löffler, A. Herchuelz, M. Mahy, Emilip Herrera, J. Garcia-Rafanell, J. Morell, Ch. Heuclin, B. H. Hicks, C. I. Taylor, S. K. Vij, S. Pek, R. F. Knopf, J. C. Floyd, S. S. Fajans, T. D. R. Hockaday, J. M. Hockaday, J. I. Mann, R. C. Turner, A. J. Honour, Y. Ikeda, S. Saito, Y. Matsuura, N. Obayashi, Y. Morimoto, T. Sano, M. Abe, R. Jacouot, J. M. Felix, C. Legrele, M. -Th. Sutter-Dub, B. Ch. J. Sutter, L. Kammerer, J. Fehér, J. Lévai, R. Dénes, M. Stützel, I. Balázsi, I. Láng, L. Littmann, C. Karakash, F. Assimacopoulos, N. Katsilambros, G. Papadopoulos, D. Varonos, G. Daikos, H. Keen, R. J. Jarrett, J. H. Fuller, N. H. K. Kiesselbach, W. Puls, U. Keup, Ryuichi Kikkawa, D. Duvillard, M. Ravazzola, W. Stauffacher, J. Köbberling, R. Kattermann, J. Kobberling, W. Creutzfeldt, Eva M. Kohner, A. M. Hamilton, G. F. Joplin, R. K. Blach, T. R. Fraser, H. J. Kolb, L. Weiss, O. H. Wieland, A. Korn, W. Waldhäusl, J. Bonelli, D. Magometsohnigg, G. Hitzenberger, Robert C. Kramp, G. J. Kremer, W. Atzpodien, B. Schnellbacher, B. Krug, P. Mialhe, R. Gross, R. Landgraf, M. Landgraf-Leurs, M. Klingenburg, I. Melamed, R. Hörl, István Láng Jun, László Littmann, Mária Stützel, Imre Balázsi, Derek R. Langslow, Keith D. Buchanan, Barry M. Freeman, Meir Berezin, I. Mincu, C. Dumitrescu, C. Ionescu-Tirgoviste, N. Mihalache, D. Boboia, J. Stanescu, E. Ghise-Beer, St. Georgescu, I. Bruckner, I. Popa, M. Muggeo, A. Tiengo, D. Padovan, M. Molinari, Walter A. Müller, and Geoffrey W. G. Sharp

Subjects
Gerontology, business.industry, Endocrinology, Diabetes and Metabolism, Association (object-oriented programming), Diabetes mellitus, Internal Medicine, medicine, Human physiology, medicine.disease, business
Published
1974
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5. Lipid abnormalities in untreated maturity-onset diabetics and the effect of treatment

Author

R. W. Simpson, J. M. Hockaday, R. Jelfs, T. D. R. Hockaday, Jim Mann, and R. C. Turner

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Hyperlipidemias, chemistry.chemical_compound, Plasma cholesterol, Internal medicine, Diabetes Mellitus, Internal Medicine, Humans, Medicine, Serum triglycerides, Triglycerides, Triglyceride, business.industry, Body Weight, Lipid Metabolism, Control subjects, Serum triglyceride levels, Cholesterol, Sulfonylurea Compounds, Endocrinology, Dietary treatment, chemistry, Female, business, After treatment, Lipoprotein
Abstract

Plasma cholesterol and serum triglyceride levels and frequency of lipoprotein abnormalities were investigated in 126 untreated maturity-onset diabetics and 126 age- and sex-matched control subjects. Serum triglyceride levels were higher (mean: 1.67 mmol/l) and type IV hyperlipoproteinaemia occurred more frequently (16.7%) in the diabetic group as compared with the controls (1.29 mmol/l and 4.8% respectively). These findings were not explained by an excessive frequency of renal disease, hypertension or drug treatment amongst the diabetics. Normal men showed higher serum triglyceride (mean: 1.36 mmol/l) and lower plasma cholesterol (mean: 5.6 mmol/l) levels than normal women (1.21 mmol/l and 6.4 mmol/l respectively). No sex difference was seen amongst the diabetics. Triglyceride levels fell after one month of dietary treatment but only remained lowered in diabetics who required sulphonylureas for glycaemic control. After treatment for one year the correlation between serum triglycerides and blood glucose rose from r = 0.15 (NS) before treatment to r = 0.43 (p less than 0.001). Similarly the correlation between serum triglycerides and ponderal index rose from r = 0.19 (NS) to r = 0.28 (p less than 0.02).

Published
1979
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7. Headache in children

Author

J M, Hockaday

Subjects
Male, Pseudotumor Cerebri, Adolescent, Brain Neoplasms, Migraine Disorders, Headache, Child, Preschool, Craniocerebral Trauma, Encephalitis, Humans, Female, Meningitis, Asthenopia, Sinusitis, Child, Cerebral Hemorrhage, Hydrocephalus
Published
1982

8. Headache and school absence

Author

J M Hockaday, W E Waters, and C Collin

Subjects
Male, Pediatrics, medicine.medical_specialty, Small town, Adolescent, education, Age and sex, Pupil, Age groups, Absenteeism, Medicine, Humans, Prospective Studies, Prospective cohort study, Child, Students, High prevalence, business.industry, Attendance, Headache, England, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Research Article
Abstract

The amount of time missed from school in two small town school populations was estimated by measuring absence from school and attendance at sickbay, and stated causes were analysed. School absence related to headache (expressed as percentage of pupil days missed out of possible pupil days, during two 12 week periods) in children aged 5 to 14 years, was 0.05%. This represented approximately 1% of all school absence, and was recorded (usually only once) in 3.7% of children. The duration of absence was one day or less on 85% of occasions. This low absence rate was in contrast with the high prevalence of headache reported by children aged 9 to 14 of between 76 and 94% according to age and sex. Attendance at school sick bay because of headache was recorded in 3.6% of children aged 5 to 19 (only 0.5% then left school early because of headache) in one 12 week period. It is concluded that although headache prevalence is high in the age groups studied, it is not a prominent cause of time missed from school.

Published
1985

9. Letter: Prolactin and migraine

Author

M T, Epstein, J M, Hockaday, and T D, Hockaday

Subjects
Adult, Ovulation, Adolescent, Migraine Disorders, Humans, Female, Prolactin
Published
1974

10. Motor neuropathy associated with abnormal pyruvate metabolism unaffected by thiamine

Author

J. M. Hockaday, T. D. R. Hockaday, and Geoffrey Rushworth

Subjects
medicine.medical_specialty, Pathology, Methionine, business.industry, Articles, medicine.disease, Psychiatry and Mental health, chemistry.chemical_compound, Endocrinology, Cerebrospinal fluid, chemistry, Internal medicine, Diabetes mellitus, medicine, Surgery, Thiamine, Neurology (clinical), Pyruvic acid, Vitamin B12, Cyanocobalamin, business, Pyruvate Metabolism
Published
1966

11. Patterns of referred pain in the normal subject

Author

C. W. M. Whitty and J. M. Hockaday

Subjects
Adult, Male, medicine.medical_specialty, Spasm, Referred pain, Ligaments, business.industry, Hyperesthesia, Hypertonic Solutions, Pain, Subject (documents), Stimulation, Chemical, Injections, Physical therapy, Medicine, Humans, Anesthesia, Female, Neurology (clinical), business, Intervertebral Disc
Published
1967

12. Book Reviews

Author

J. M. Hockaday

Subjects
Psychiatry and Mental health, Surgery, Neurology (clinical)
Published
1968
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15. SEROTONIN

Author

J. M. Hockaday

Subjects
Psychiatry and Mental health, Surgery, Neurology (clinical)
Published
1969
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