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3. COVID-19 and necessity-based online entrepreneurship education at US community colleges

Author

Christoph Winkler, Jeffrey Muldoon, Lee J. Zane, Doan Winkel, and Eric W. Liguori

Subjects
Entrepreneurship, Medical education, business.industry, Strategy and Management, media_common.quotation_subject, 05 social sciences, Professional development, 050301 education, Experiential learning, Originality, Publishing, General partnership, 0502 economics and business, Pandemic, Business, Management and Accounting (miscellaneous), Sociology, Natural disaster, business, 0503 education, 050203 business & management, media_common
Abstract

PurposeThis paper explores community college entrepreneurship education's near-instantaneous transition to online course delivery following the 2020 COVID-19 pandemic.Design/methodology/approachPrimary data were obtained from 92 community college entrepreneurship faculty via online survey in late March of 2020, right at the time faculty were required to transition their courses to an online mode of delivery due to the COVID-19 pandemic. Data were collected in partnership with the National Association for Community College Entrepreneurship and the Entrepreneurship Education Project.FindingsWhile the majority of community college entrepreneurship educators have taught online previously, many were not familiar with exemplar education technology tools and applications, demonstrating an opportunity for continued professional development. To deliver courses online, educators primarily relied on pre-recorded lectures and using Zoom as the technology platform of choice. Last, there were significant faculty concerns about their ability to effectively create an “experiential” classroom virtually for students to learn and practice entrepreneurship.Originality/valueThis is the first paper investigating how community college entrepreneurship educators responded to one of the most disruptive events to ever impact entrepreneurship education (viz. the COVID-19 pandemic). More broadly, this is also one of very few studies exploring both (1) community college entrepreneurship education and (2) how unexpected crises (e.g. natural disasters, pandemics) impact educational environments.

Published
2021
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4. Phytotherapeutics and Probiotics as an Alternative to the Use of Antimicrobials in the Diets of Laying Quails

Author

J Zanella, JK Valentim, AA Almeida, RG Garcia, CM Komiyama, PH Braz, MFC Burbarelli, FC Serpa, FR Caldara, BB Przybulinski, VARC Heiss, and DD Moraleco

Subjects
Blend of essential oils, quail farming, reproductive performance, propolis, Animal culture, SF1-1100, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

ABSTRACT This study evaluated the substitution of commercial antibiotics with phytotherapeutics and probiotics in Japanese quail diets during the rearing phase, and their effects on performance, serum metabolites, organ weight and size, and egg quality in the initial laying phase. Conducted over 42 days with 300 quails, starting at 21 days of age and an average weight of 87 ± 3.5 g, the quails were divided into five groups: negative control (no additives), commercial antibiotics, probiotics (BS Gold®), essential oils (Phyto 100®), and natural pollen. The experiment was analyzed using variance analysis and Tukey’s test with a 5% significance level. Feed conversion differed significantly in the periods between 28-35 and 35-42 days. Egg quality showed variations, with higher albumen height in the probiotic group, better yolk height and luminosity with pollen, increased luminosity in the control group, and a larger yolk diameter with phytotherapeutics. The findings indicated that essential oils, probiotics, and pollen effectively replaced antibiotics without negatively affecting zootechnical performance, serum metabolites, or organ weight and size. Additionally, egg performance and quality were maintained during the initial laying phase.

Published
2025
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5. Editorial: Special Issue on Interdisciplinary and Experiential Entrepreneurship Education

Author

Christoph Winkler, Lee J. Zane, Donna Levin, Dennis Barber, Doan Winkel, and Julienne Shields

Subjects
Entrepreneurship education, biology, Interdisciplinary education, Pedagogy, ComputingMilieux_COMPUTERSANDEDUCATION, Sociology, Rowan, biology.organism_classification, Experiential learning
Abstract

A group of six colleges and universities (East Carolina University, Iona College, John Carroll University, Millikin University, Rowan University, Worcester Polytechnic Institute) partnered up to co-host the January 2020 USASBE Conference in New Orleans, LA, with the theme Interdisciplinary & Experiential Entrepreneurship Education. The conference thematically aligned its overall program with this special issue, which features scholars and programs representing the arts, design, engineering, liberal arts, physical sciences, STEM, and – yes – business. This editorial further discusses the importance of interdisciplinary entrepreneurship education as an inherent feature of itself to truly evolve as a discipline.

Published
2021
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6. Critical methodological considerations for entrepreneurial cognition research

Author

Vadake Narayanan, Lee J. Zane, and Eric W. Liguori

Subjects
Cognitive science, Entrepreneurship, Management of Technology and Innovation, Strategy and Management, 0502 economics and business, 05 social sciences, Research based, 050211 marketing, Cognition, Psychology, General Business, Management and Accounting, 050203 business & management
Abstract

This article synthesizes and explores the methods used in Entrepreneurial Cognition research based on a review of articles published between 1993–2017. Through analysis and classification of 182 en...

Published
2020
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8. The Connections Between Founders’ Social Network and Human Capital in Technology-Based New Ventures

Author

Lee J. Zane and Donna Marie DeCarolis

Subjects
Management of Technology and Innovation, Strategy and Management, Business and International Management
Abstract

This research examines the relationship between a founding team’s social network and the acquisition of its critical human capital. First, explicitly dealing with technology-based firms, we disaggregate the founder(s) social network into four sub-networks: academic, industry, finance, and personal (family and community). Then, we detail the relationship between these individual sub-networks and the acquisition of both technical and business skilled human capital. Our results confirm that individual sub-networks have a differential effect on acquiring both technical and business human capital.

Published
2021
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14. Social networks and the acquisition of resources by technology-based new ventures

Author

Donna Marie DeCarolis and Lee J. Zane

Subjects
Knowledge management, Social network, Relation (database), business.industry, Strategy and Management, 05 social sciences, New Ventures, Human capital, Commercialization, Financial capital, 0502 economics and business, Resource Acquisition Is Initialization, Key (cryptography), Business, 050207 economics, Business and International Management, Economic system, 050203 business & management
Abstract

Our proposed model focuses on the relationship between specific components of an entrepreneur's social network and the acquisition of three key resources (human capital, financial capital, and alliances) needed for a technology-based new venture to reach the stage of commercialization. Specifically, we disaggregate the social network of founders into four specialized sub networks: academic, industry, finance, and family and highlight the benefits of each for resource acquisition. We then discuss strength of ties versus breadth of contacts in relation to the acquisition of resources. Social network theory is used to explain the model.

Published
2016
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15. The Moving to Health (M2H) approach to natural experiment research: A paradigm shift for studies on built environment and health

Author

Paula Lozano, Anne Vernez Moudon, Phil Hurvitz, David Arterburn, Anju Aggarwal, Shilpi Gupta, Andrea J. Cook, Jennifer F. Bobb, J. Zane, Dori E. Rosenberg, and Adam Drewnowski

Subjects
Health (social science), Geographic information system, Natural experiment, Computer science, Article, Geographic information systems (GIS), 03 medical and health sciences, 0302 clinical medicine, Health care, Obesity, 030212 general & internal medicine, Social determinants of health, lcsh:Social sciences (General), Electronic medical records, Research question, Built environment, 030505 public health, business.industry, lcsh:Public aspects of medicine, Health Policy, Diabetes, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Natural experiments, Data science, 3. Good health, Paradigm shift, Built environment (BE), Survey data collection, lcsh:H1-99, 0305 other medical science, business, Residential mobility
Abstract

Improving the built environment (BE) is viewed as one strategy to improve community diets and health. The present goal is to review the literature on the effects of BE on health, highlight its limitations, and explore the growing use of natural experiments in BE research, such as the advent of new supermarkets, revitalized parks, or new transportation systems. Based on recent studies on movers, a paradigm shift in built-environment health research may be imminent. Following the classic Moving to Opportunity study in the US, the present Moving to Health (M2H) strategy takes advantage of the fact that changing residential location can entail overnight changes in multiple BE variables. The necessary conditions for applying the M2H strategy to Geographic Information Systems (GIS) databases and to large longitudinal cohorts are outlined below. Also outlined are significant limitations of this approach, including the use of electronic medical records in lieu of survey data. The key research question is whether documented changes in BE exposure can be linked to changes in health outcomes in a causal manner. The use of geo-localized clinical information from regional health care systems should permit new insights into the social and environmental determinants of health., Highlights • The present Moving to Health approach represents a new type of a “natural experiment” • While built environment (BE) is fixed in place, moving to a new residential location can change one’s BE virtually overnight. • The question is whether such a shift in BE exposure have any long-term impact on health, body weight or diabetes outcomes.

Published
2019
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16. Competitive Moves: The Influence of Industry Context and Individual Cognitive Factors

Author

William Adam Kline and Lee J. Zane

Subjects
Entrepreneurship, business.industry, Strategy and Management, media_common.quotation_subject, 05 social sciences, Sample (statistics), Context (language use), 02 engineering and technology, Cognitive bias, 020501 mining & metallurgy, 0205 materials engineering, Action (philosophy), Management of Technology and Innovation, Perception, 0502 economics and business, Economics, First-mover advantage, Business and International Management, Marketing, business, Tertiary sector of the economy, 050203 business & management, Industrial organization, media_common
Abstract

Businesses compete in markets with significant uncertainty and choose disparate competitive strategies. Some attack while others appear to wait. While real options logic has been used to explain market entry and exit decisions under uncertainty, few have tied this logic to the characteristics of ventures’ competitive moves. This paper discusses how ventures launch competitive moves, particularly the speed and intensity of action, under contrasting conditions of exogenous uncertainty and first-mover advantage. We argue that the speed and intensity with which entrepreneurs conduct competitive activities are contingent on both their perceptions of the environment and their level of certain cognitive biases. We conducted a two-by-two within-subjects design experiment to test our hypotheses with a sample consisting of service industry professionals.

Published
2017
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17. The Cognitive Perspective in Strategy: An Integrative Review

Author

Benedict Kemmerer, Vadake Narayanan, and Lee J. Zane

Subjects
Strategic planning, Knowledge management, Organizational identity, Management science, business.industry, Process (engineering), Strategy and Management, Cognition, Sensemaking, Strategy implementation, Empirical research, Organizational learning, Psychology, business, Finance
Abstract

This article integrates the literature on strategic cognition (SC) within a framework that links the antecedents, structure, and process of SC with outcomes. Reviewing the literature from 1993 (two years prior to Walsh’s review of managerial and organizational cognition) until 2007, this article identifies three elements of SC structure (organizational identity, strategy frames, and organizational routines) and four SC processes (strategy formulation, strategy implementation, strategic change, and organizational learning). The literature portrays strategy formulation as a complex activity consisting of scanning, sensemaking, and decision making. Strategy implementation is composed of sensegiving, sensemaking, and issue selling. This review identifies five streams of empirical research with three well-developed themes (the antecedents and outcomes of strategy frames, determinants and consequences of strategy formulation, and cognitive construction of competitive/industry dynamics) and two emerging themes (the determinants and consequences of strategy implementation and the antecedents and outcomes of organizational identity). This review identifies several opportunities to extend the literature and outlines key methodological implications. Finally, the review addresses the need to build linkages to the ongoing theoretical conversations within strategic management literature.

Published
2010
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18. Emulsifier in Diets with Different Alternative Lipid Sources: Effects on the Health of Japanese Quails

Author

FC Serpa, RG Garcia, MFC Burbarelli, CM Komiyama, JK Valentim, VAR Castilho, DP Della-Flora, BB Przybulinski, PH Braz, J Zanella, RHTB Goes, and FR Caldara

Subjects
Bovine tallow, intestinal morphometry, poultry fat, soybean oil, serum biochemical profile, Animal culture, SF1-1100, Veterinary medicine, SF600-1100, Zoology, QL1-991
Abstract

ABSTRACT The present research aims to evaluate the inclusion of an emulsifying additive based on mono- and diglycerides of fatty acids in diets with different lipid sources, studying its effects on duodenum histology, biometry of the digestive and reproductive tract, and blood biochemical profile of Japanese quails. The study was carried out in the experimental aviary of the Federal University of Grande Dourados, Mato Grosso do Sul, Brazil. The experimental design was completely randomized, with diets in a 3x2 factorial design with three different lipid sources (soybean oil, poultry fat, and beef tallow), either supplemented or not with an emulsifier. The birds that received a diet composed of poultry fat and an emulsifying additive had a larger gizzard. Animals that received a diet containing an emulsifier, regardless of the lipid source, had greater heart weight. The duodenum of animals that received bovine tallow in their diet showed a greater height and villus:crypt ratio. Biochemical parameters were not affected by either the lipid source or the inclusion of emulsifier in quail diets. The biochemical blood profile of birds in treatments did not show significant changes among all diets used. The use of soybean oil, bovine tallow, and poultry fat with or without the inclusion of an emulsifier does not show changes in the health and development of the quails’ organs, which also indicates that the health of Japanese quails in the laying phase is kept in good standards.

Published
2023
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19. LOFT: the Large Observatory For X-ray Timing

Author

M. Feroci, JW den Herder, JW Bozzo, E. Barret, D. Brandt, S. Hernanz, M. van der Klis, M. Pohl, M. Santangelo, A. Stella, L. Watts, A. Wilms, J. Zane, S. Ahangarianabhari, M. Alpar, A. Altamirano, D. Alvarez, L. Amati, L. Amoros, C. Andersson, N. Antonelli, A. Argan, A. Artigue R, Azzarello P, Balman, S. Barbera, M. Belloni, T. Bertuccio, G. Bianchi, S. Bianchini, A. Bodin, P. Bidaud, JMB Boutloukos, S. Braga, J. Brown, E. Bucciantini, N. Burderi, L. Bursa, M. Budtz Jorgensen, C. Cackett, E. Cadoux, FR Cais, P. Caliandro, GA Campana, R. Campana, S. Casella, P. Chakrabarty, D. Chenevez, J. Coker, J. Cole, R. Collura, A. Courvoisier, T. Cros, A. Cumming, A. Cusumano, G. D'Ai, A. D'Elia, V. Del Monte, E. De Martino, D. De Rosa, A. Di Cosimo, S. Diebold, S. Di Salvo, T. Donnarumma, I. Drago, A. Durant, M. Emmanoulopoulos, D. Evangelista, Y. Fabian, A. Falanga, M. Favre, Y. Feldman, C. Ferrigno, C. Finger, MH Fraser, GW Fuschino, F. Galloway, DK Sanchez, JLG Garcia Berro, E. Gendre, B. Gezari, S. Giles, AB Gilfanov, M. Giommi, P. Giovannini, G. Giroletti, M. Goldwurm, A. Gotz, D. Gouiffes, C. Grassi, M. Groot, P. Guidorzi, C. Haas, D. Hansen, F. Hartmann, DH Haswell, CA Heger, A. Homan, J. Hornstrup, A. Hudec, R. Huovelin, J. Ingram, A. in't Zand, JJM Isern, J. Israel, G. Izzo, L. Jonker, P. Kaaret, P. Karas, V. Karelin, D. Kataria, D. Keek, L. Kennedy, T. Klochkov, D. Kluzniak, W. Kokkotas, K. Korpela, S. Kouveliotou, C. Kreykenbohm, I. Kuiper, LM Kuvvetli, I. Labanti, C. Lai, D. Lamb, FK Lebrun, F. Lin, D. Linder, D. Lodato, G. Longo, F. Lund, N. Maccarone, TJ Macera, D. Maier, D. Malcovati, P. Mangano, V. Manousakis, A. Marisaldi, M. Markowitz, A. Martindale, A. Matt, G. McHardy, IM Melatos, A. Mendez, M. Migliari, S. Mignani, R. Miller, MC Miller, JM Mineo, T. Miniutti, G. Morsink, S. Motch, C. Motta, S. Mouchet, M. Muleri, F. Norton, AJ Nowak, M. O'Brien, P. Orienti, M. Orio, M. Orlandini, M. Orleanski, P. Osborne, JP Osten, R. Ozel, F. Pacciani, L. Papitto, A. Paul, B. Perinati, E. Petracek, V. Portell, J. Poutanen, J. Psaltis, D. Rambaud, D. Ramsay, G. Rapisarda, M. Rachevski, A. Ray, PS Rea, N. Reddy, S. Reig, P. Aranda, MR Remillard, R. Reynolds, C. Rodriuez Gil, P. Rodriguez, J. Romano, P. Rossi, EMR Ryde, F. Sabau Graziati, L. Sala, G. Salvaterra, R. Sanna, A. Schanne, S. Schee, J. Schmid, C. Schwenk, A. Schwope, AD Seyler, JY Shearer, A. Smith, DM Smith, PJ Sochora, V. Soffitta, P. Soleri, P. Stappers, B. Stelzer, B. Stergioulas, N. Stratta, G. Strohmayer, TE Stuchlik, Z. Suchy, S. Sulemainov, V. Takahashi, T. Tamburini, F. Tenzer, C. Tolos, L. Torok, G. Torrejon, JM Torres, DF Tramacere, A. Trois, A. Turriziani, S. Uter, P. Uttley, P. Vacchi, A. Varniere, P. Vaughan, S. Vercellone, S. Vrba, V. Walton, D. Watanabe, S. Wawrzaszek, R. Webb, N. Weinberg, N. Wende, H. Wheatley, P. Wijers, R. Wijnands, R. Wille, M. Wilson Hodge, CA Winter, B. Wood, K. Zampa, G. Zampa, N. Zampieri, L. Zdziarski, A. Zhang, BALDAZZI, GIUSEPPE, FORMATION STELLAIRE 2012, Laboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux (L3AB), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), Istituto di Astrofisica e Planetologia Spaziali - INAF (IAPS), Istituto Nazionale di Astrofisica (INAF), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL), PCAS, APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Istituto di Fisica dello Spazio Interplanetario (IFSI), Consiglio Nazionale delle Ricerche (CNR), Laboratoire Univers et Théories (LUTH (UMR_8102)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Centrale Lille Institut (CLIL), Laboratoire d’Optique Atmosphérique - UMR 8518 (LOA), Institut national des sciences de l'Univers (INSU - CNRS)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), NOAA Geophysical Fluid Dynamics Laboratory (GFDL), National Oceanic and Atmospheric Administration (NOAA), Departamento de Biología Animal (Universidad de Granada), Universidad de Granada (UGR), Estación Experimental de Zonas Áridas (CSIC), Universitat Politècnica de Catalunya [Barcelona] (UPC), INAF-IASF Milano, Groupe d'Etudes des Matériaux Hétérogènes (GEMH), Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Institute of Geology, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Tadayuki Takahashi, Stephen S. Murray, Jan-Willem A. den Herder, Shiro Ueno, LOFT, Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire aquitain des sciences de l'univers (OASU), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universidad de Granada = University of Granada (UGR), Feroci, M, den Herder, JW, Bozzo, E, Barret, D, Brandt, S, Hernanz, M, van der Klis, M, Pohl, M, Santangelo, A, Stella, L, Watts, A, Wilms, J, Zane, S, Ahangarianabhari, M, Alpar, A, Altamirano, D, Alvarez, L, Amati, L, Amoros, C, Andersson, N, Antonelli, A, Argan, A, Artigue, R, Azzarello, P, Baldazzi, G, Balman, S, Barbera, M, Belloni, T, Bertuccio, G, Bianchi, S, Bianchini, A, Bodin, P, Bonnet Bidaud, J-M, Boutloukos, S, Braga, J, Brown, E, Bucciantini, N, Burderi, L, Bursa, M, Budtz-Jørgensen, C, Cackett, E, Cadoux, F R, Cais, P, Caliandro, G A, Campana, R, Campana, S, Casella, P, Chakrabarty, D, Chenevez, J, Coker, J, Cole, R, Collura, A, Courvoisier, T, Cros, A, Cumming, A, Cusumano, G, D'Ai, A, D'Elia, V, Del Monte, E, de Martino, D, De Rosa, A, Di Cosimo, S, Diebold, S, Di Salvo, T, Donnarumma, I, Drago, A, Durant, M, Emmanoulopoulos, D, Evangelista, Y, Fabian, A, Falanga, M, Favre, Y, Feldman, C, Ferrigno, C, Finger, M H, Fraser, GW, Fuschino, F, Galloway, DK, Galvez Sanchez, JL, Garcia-Berro, E, Gendre, B, Gezari, S, Giles, AB, Gilfanov, M, Giommi, P, Giovannini, G, Giroletti, M, Goldwurm, A, Götz, D, Gouiffes, C, Grassi, M, Groot, P, Guidorzi, C, Haas, D, Hansen, F, Hartmann, D H, Haswell, C A, Heger, A, Homan, J, Hornstrup, A, Hudec, R, Huovelin, J, Ingram, A, In't Zand, J J M, Isern, J, Israel, G, Izzo, L, Jonker, P, Kaaret, P, Karas, V, Karelin, D, Kataria, D, Keek, L, Kennedy, T, Klochkov, D, Kluzniak, W, Kokkotas, K, Korpela, S, Kouveliotou, C, Kreykenbohm, I, Kuiper, L M, Kuvvetli, I, Labanti, C, Lai, D, Lamb, F K, Lebrun, F, Lin, D, Linder, D, Lodato, G, Longo, F, Lund, N, Maccarone, TJ, Macera, D, Maier, D, Malcovati, P, Mangano, V, Manousakis, A, Marisaldi, M, Markowitz, A, Martindale, A, Matt, G, McHardy, IM, Melatos, A, Mendez, M, Migliari, S, Mignani, R, Miller, M C, Miller, J M, Mineo, T, Miniutti, G, Morsink, S, Motch, C, Motta, S, Mouchet, M, Muleri, F, Norton, AJ, Nowak, M, O'Brien, P, Orienti, M, Orio, M, Orlandini, M, Orleanski, P, Osborne, J P, Osten, R, Ozel, F, Pacciani, L, Papitto, A, Paul, B, Perinati, E, Petracek, V, Portell, J, Poutanen, J, Psaltis, D, Rambaud, D, Ramsay, G, Rapisarda, M, Rachevski, A, Ray, P S, Rea, N, Reddy, S, Reig, P, Reina Aranda, M, Remillard, R, Reynolds, C, Rodríguez-Gil, P, Rodriguez, J, Romano, P, Rossi, E M R, Ryde, F, Sabau-Graziati, L, Sala, G, Salvaterra, R, Sanna, A, Schanne, S, Schee, J, Schmid, C, Schwenk, A, Schwope, A D, Seyler, J-Y, Shearer, A, Smith, A, Smith, D M, Smith, P J, Sochora, V, Soffitta, P, Soleri, P, Stappers, B, Steltzer, B, Stergioulas, N, Stratta, G, Strohmayer, T E, Stuchlik, Z, Suchy, S, Sulemainov, V, Takahashi, T, Tamburini, F, Tenzer, C, Tolos, L, Torok, G, Torrejon, J M, Torres, D F, Tramacere, A, Trois, A, Turriziani, S, Uter, P, Uttley, P, Vacchi, A, Varniere, P, Vaughan, S, Vercellone, S, Vrba, V, Walton, D, Watanabe, S, Wawrzaszek, R, Webb, N, Weinberg, N, Wende, H, Wheatley, P, Wijers, R, Wijnands, R, Wille, M, Wilson-Hodge, C A, Winter, B, Wood, K, Zampa, G, Zampa, N, Zampieri, L, Zdziarski, A, Zhang, B, High Energy Astrophys. & Astropart. Phys (API, FNWI), Feroci, M., den Herder, J. W., Bozzo, E., Barret, D., Brandt, S., Hernanz, M., van der Klis, M., Pohl, M., Santangelo, A., Stella, L., Watts, A., Wilms, J., Zane, S., Ahangarianabhari, M., Alpar, A., Altamirano, D., Alvarez, L., Amati, L., Amoros, C., Andersson, N., Antonelli, A., Argan, A., Artigue, R., Azzarello, P., Baldazzi, G., Balman, S., Barbera, M., Belloni, T., Bertuccio, G., Bianchi, S., Bianchini, A., Bodin, P., Bonnet Bidaud, J. M., Boutloukos, S., Braga, J., Brown, E., Bucciantini, N., Burderi, L., Bursa, M., Budtz Jørgensen, C., Cackett, E., Cadoux, F. R., Cais, P., Caliandro, G. A., Campana, R., Campana, S., Casella, P., Chakrabarty, D., Chenevez, J., Coker, J., Cole, R., Collura, A., Courvoisier, T., Cros, A., Cumming, A., Cusumano, G., D'Ai, A., D'Elia, V., Del Monte, E., de Martino, D., De Rosa, A., Di Cosimo, S., Diebold, S., Di Salvo, T., Donnarumma, I., Drago, A., Durant, M., Emmanoulopoulos, D., Evangelista, Y., Fabian, A., Falanga, M., Favre, Y., Feldman, C., Ferrigno, C., Finger, M. H., Fraser, G. W., Fuschino, F., Galloway, D. K., Galvez Sanchez, J. L., Garcia Berro, E., Gendre, B., Gezari, S., Giles, A. B., Gilfanov, M., Giommi, P., Giovannini, G., Giroletti, M., Goldwurm, A., Götz, D., Gouiffes, C., Grassi, M., Groot, P., Guidorzi, C., Haas, D., Hansen, F., Hartmann, D. H., Haswell, C. A., Heger, A., Homan, J., Hornstrup, A., Hudec, R., Huovelin, J., Ingram, A., In't Zand, J. J. M., Isern, J., Israel, G., Izzo, L., Jonker, P., Kaaret, P., Karas, V., Karelin, D., Kataria, D., Keek, L., Kennedy, T., Klochkov, D., Kluzniak, W., Kokkotas, K., Korpela, S., Kouveliotou, C., Kreykenbohm, I., Kuiper, L. M., Kuvvetli, I., Labanti, C., Lai, D., Lamb, F. K., Lebrun, F., Lin, D., Linder, D., Lodato, G., Longo, Francesco, Lund, N., Maccarone, T. J., Macera, D., Maier, D., Malcovati, P., Mangano, V., Manousakis, A., Marisaldi, M., Markowitz, A., Martindale, A., Matt, G., Mchardy, I. M., Melatos, A., Mendez, M., Migliari, S., Mignani, R., Miller, M. C., Miller, J. M., Mineo, T., Miniutti, G., Morsink, S., Motch, C., Motta, S., Mouchet, M., Muleri, F., Norton, A. J., Nowak, M., O'Brien, P., Orienti, M., Orio, M., Orlandini, M., Orleanski, P., Osborne, J. P., Osten, R., Ozel, F., Pacciani, L., Papitto, A., Paul, B., Perinati, E., Petracek, V., Portell, J., Poutanen, J., Psaltis, D., Rambaud, D., Ramsay, G., Rapisarda, M., Rachevski, A., Ray, P. S., Rea, N., Reddy, S., Reig, P., Reina Aranda, M., Remillard, R., Reynolds, C., Rodríguez Gil, P., Rodriguez, J., Romano, P., Rossi, E. M. R., Ryde, F., Sabau Graziati, L., Sala, G., Salvaterra, R., Sanna, A., Schanne, S., Schee, J., Schmid, C., Schwenk, A., Schwope, A. D., Seyler, J. Y., Shearer, A., Smith, A., Smith, D. M., Smith, P. J., Sochora, V., Soffitta, P., Soleri, P., Stappers, B., Steltzer, B., Stergioulas, N., Stratta, G., Strohmayer, T. E., Stuchlik, Z., Suchy, S., Sulemainov, V., Takahashi, T., Tamburini, F., Tenzer, C., Tolos, L., Torok, G., Torrejon, J. M., Torres, D. F., Tramacere, A., Trois, A., Turriziani, S., Uter, P., Uttley, P., Vacchi, A., Varniere, P., Vaughan, S., Vercellone, S., Vrba, V., Walton, D., Watanabe, S., Wawrzaszek, R., Webb, N., Weinberg, N., Wende, H., Wheatley, P., Wijers, R., Wijnands, R., Wille, M., Wilson Hodge, C. A., Winter, B., Wood, K., Zampa, G., Zampa, N., Zampieri, L., Zdziarski, A., Zhang, B., Astronomy, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrochimie Infrarouge et Raman - UMR 8516 (LASIR), Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology in Zürich [Zürich] (ETH Zürich), SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA, M Feroci, JW den Herder, JW Bozzo, E Barret, D Brandt, S Hernanz, M van der Kli, M Pohl, M Santangelo, A Stella, L Watt, A Wilm, J Zane, S Ahangarianabhari, M Alpar, A Altamirano, D Alvarez, L Amati, L Amoro, C Andersson, N Antonelli, A Argan, A Artigue R, Azzarello P, G Baldazzi, Balman, S Barbera, M Belloni, T Bertuccio, G Bianchi, S Bianchini, A Bodin, P Bidaud, JMB Boutlouko, S Braga, J Brown, E Bucciantini, N Burderi, L Bursa, M Budtz-Jorgensen, C Cackett, E Cadoux, FR Cai, P Caliandro, GA Campana, R Campana, S Casella, P Chakrabarty, D Chenevez, J Coker, J Cole, R Collura, A Courvoisier, T Cro, A Cumming, A Cusumano, G D'Ai, A D'Elia, V Del Monte, E De Martino, D De Rosa, A Di Cosimo, S Diebold, S Di Salvo, T Donnarumma, I Drago, A Durant, M Emmanoulopoulo, D Evangelista, Y Fabian, A Falanga, M Favre, Y Feldman, C Ferrigno, C Finger, MH Fraser, GW Fuschino, F Galloway, DK Sanchez, JLG Garcia-Berro, E Gendre, B Gezari, S Gile, AB Gilfanov, M Giommi, P Giovannini, G Giroletti, M Goldwurm, A Gotz, D Gouiffe, C Grassi, M Groot, P Guidorzi, C Haa, D Hansen, F Hartmann, DH Haswell, CA Heger, A Homan, J Hornstrup, A Hudec, R Huovelin, J Ingram, A in't Zand, JJM Isern, J Israel, G Izzo, L Jonker, P Kaaret, P Kara, V Karelin, D Kataria, D Keek, L Kennedy, T Klochkov, D Kluzniak, W Kokkota, K Korpela, S Kouveliotou, C Kreykenbohm, I Kuiper, LM Kuvvetli, I Labanti, C Lai, D Lamb, FK Lebrun, F Lin, D Linder, D Lodato, G Longo, F Lund, N Maccarone, TJ Macera, D Maier, D Malcovati, P Mangano, V Manousaki, A Marisaldi, M Markowitz, A Martindale, A Matt, G McHardy, IM Melato, A Mendez, M Migliari, S Mignani, R Miller, MC Miller, JM Mineo, T Miniutti, G Morsink, S Motch, C Motta, S Mouchet, M Muleri, F Norton, AJ Nowak, M O'Brien, P Orienti, M Orio, M Orlandini, M Orleanski, P Osborne, JP Osten, R Ozel, F Pacciani, L Papitto, A Paul, B Perinati, E Petracek, V Portell, J Poutanen, J Psalti, D Rambaud, D Ramsay, G Rapisarda, M Rachevski, A Ray, PS Rea, N Reddy, S Reig, P Aranda, MR Remillard, R Reynold, C Rodriuez-Gil, P Rodriguez, J Romano, P Rossi, EMR Ryde, F Sabau-Graziati, L Sala, G Salvaterra, R Sanna, A Schanne, S Schee, J Schmid, C Schwenk, A Schwope, AD Seyler, JY Shearer, A Smith, DM Smith, PJ Sochora, V Soffitta, P Soleri, P Stapper, B Stelzer, B Stergioula, N Stratta, G Strohmayer, TE Stuchlik, Z Suchy, S Sulemainov, V Takahashi, T Tamburini, F Tenzer, C Tolo, L Torok, G Torrejon, JM Torre, DF Tramacere, A Troi, A Turriziani, S Uter, P Uttley, P Vacchi, A Varniere, P Vaughan, S Vercellone, S Vrba, V Walton, D Watanabe, S Wawrzaszek, R Webb, N Weinberg, N Wende, H Wheatley, P Wijer, R Wijnand, R Wille, M Wilson-Hodge, CA Winter, B Wood, K Zampa, G Zampa, N Zampieri, L Zdziarski, A Zhang, Pohl, Martin, Cadoux, Franck, and Favre, Yannick

Subjects
[PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Vision, X-ray timing, Astronomy, SPIE Proceedings, Observatories, X-ray timing, X-ray spectroscopy, X-ray imaging, compact objects, Silicon Drift Chambers, FOS: Physical sciences, ddc:500.2, X-ray missions, Space (mathematics), Astrophysics, 01 natural sciences, 7. Clean energy, Settore FIS/05 - Astronomia E Astrofisica, X-rays, 0103 physical sciences, Electronic, Optical and Magnetic Materials, Instrumentation (computer programming), Electrical and Electronic Engineering, Aerospace engineering, Diagnostics, Compact objects, 010303 astronomy & astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, Spatial resolution, sezele, Sensors, 010308 nuclear & particles physics, business.industry, Applied Mathematics, X-ray imaging, Silicon Drift Chamber, Computer Science Applications1707 Computer Vision and Pattern Recognition, Condensed Matter Physics, X-ray spectroscopy, Electronic, Optical and Magnetic Materials, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Instrumentation and Methods for Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract

The LOFT mission concept is one of four candidates selected by ESA for the M3 launch opportunity as Medium Size missions of the Cosmic Vision programme. The launch window is currently planned for between 2022 and 2024. LOFT is designed to exploit the diagnostics of rapid X-ray flux and spectral variability that directly probe the motion of matter down to distances very close to black holes and neutron stars, as well as the physical state of ultra-dense matter. These primary science goals will be addressed by a payload composed of a Large Area Detector (LAD) and a Wide Field Monitor (WFM). The LAD is a collimated (, Proceedings of SPIE, Vol. 8443, Paper No. 8443-85, 2012

Published
2012
Full Text
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20. The Influence of Cognitive Biases on Opportunity Cost and Value When Evaluating a New Venture

Author

Lee J. Zane, Donna Marie DeCarolis, and Marco S. DiRenzo

Subjects
education.field_of_study, Opportunity cost, Actuarial science, Relation (database), Value (economics), Population, Economics, General Medicine, education, Cognitive bias
Abstract

Why do entrepreneurs pursue opportunities when others do not? Differences between entrepreneurs and the general population exist in relation to various cognitive biases. These cognitive biases affe...

Published
2014
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21. Randomized trial of switching rheumatoid arthritis patients in remission with injectable gold to auranofin

Author

M. Bulanowski, M. Krailo, J. Zane, and P. E. Prete

Subjects
Male, medicine.medical_specialty, Auranofin, Administration, Oral, Gastroenterology, Injections, Intramuscular, law.invention, Arthritis, Rheumatoid, Rheumatology, Randomized controlled trial, law, Internal medicine, medicine, Humans, Prospective Studies, business.industry, General Medicine, medicine.disease, Surgery, Radiography, Aurothioglucose, Treatment Outcome, Rheumatoid arthritis, Patient Compliance, Female, Gold, business, medicine.drug
Abstract

This prospective unblinded 24-month-study compared the therapeutic value of oral gold with injectable gold to maintain rheumatoid arthritis (RA) patients in clinical remission and prevent the progression of erosive disease. Forty-six patients with definite RA in remission with injectable gold were randomized into two groups: a control group, continued on maintenance injectable gold (Solganal, aurothioglucose, 50-100 mg, intramuscularly, 2 to 4 weeks); and an experimental group, switched to oral gold (6-9 mg auranofin by mouth daily). Only 29% of the original 24 oral gold patients remained on assigned treatment at 24 months compared with 64% of the injectable gold group. By six months, over one-half of the oral gold patients had electively stopped their randomized therapy. Sixty-seven percent of the oral gold patients had adverse reactions, mostly gastrointestinal complaints, compared with one proteinuria in the injectable gold group. The oral gold group experienced significantly more deterioration in all the primary measures of treatment effect over the follow-up period. At the termination of the trial, 88% of the group had increases of 5 or more points in radiographic scores suggesting progression of erosive disease compared with only 29% of the control group. These data suggest that oral gold is not an effective substitute for injectable gold in maintaining remission in rheumatoid arthritis.

Published
1994

22. A novel mutation in the mitochondrial tRNASer(AGY) gene associated with mitochondrial myopathy, encephalopathy, and complex I deficiency

Author

C. L. Hoppel, R. K. Bai, Lee-Jun C. Wong, J. Zane, D. S. Kerr, M. M. Vacek, H. Kwon, and D. Yim

Subjects
Mitochondrial encephalomyopathy, Mitochondrial DNA, DNA Mutational Analysis, Molecular Sequence Data, Biology, Mitochondrion, Electronic Letter, MELAS syndrome, DNA, Mitochondrial, Oxidative Phosphorylation, Mitochondrial myopathy, MELAS Syndrome, Genetics, medicine, Humans, Child, Muscle, Skeletal, RNA, Transfer, Ser, Genetics (clinical), Electron Transport Complex I, Base Sequence, Genome, Human, Infant, Newborn, MERRF syndrome, Infant, medicine.disease, Molecular biology, MERRF Syndrome, Heteroplasmy, Mitochondria, Muscle, Mitochondrial respiratory chain, Case-Control Studies, Child, Preschool, Mutation, Nucleic Acid Conformation, Female
Abstract

Purpose To identify molecular defects in a girl with clinical features of MELAS (mitochondrial encephalomyopathy and lactic acidosis) and MERRF (ragged-red fibres) syndromes. Methods The enzyme complex activities of the mitochondrial respiratory chain were assayed. Temporal temperature gradient gel electrophoresis was used to scan the entire mitochondrial genome for unknown mitochondrial DNA (mtDNA) alterations, which were then identified by direct DNA sequencing. Results A novel heteroplasmic mtDNA mutation, G12207A, in the tRNA(Ser(AGY)) gene was identified in the patient who had a history of developmental delay, feeding difficulty, lesions within her basal ganglia, cerebral atrophy, proximal muscle weakness, increased blood lactate, liver dysfunction, and fatty infiltration of her muscle. Muscle biopsy revealed ragged red fibres and pleomorphic mitochondria. Study of skeletal muscle mitochondria revealed complex I deficiency associated with mitochondrial proliferation. Real time quantitative PCR analysis showed elevated mtDNA content, 2.5 times higher than normal. The tRNA(Ser(AGY)) mutation was found in heteroplasmic state (92%) in the patient's skeletal muscle. It was not present in her unaffected mother's blood or in 200 healthy controls. This mutation occurs at the first nucleotide of the 5' end of tRNA, which is involved in the formation of the stem region of the amino acid acceptor arm. Mutation at this position may affect processing of the precursor RNA, the stability and amino acid charging efficiency of the tRNA, and overall efficiency of protein translation. Conclusion This case underscores the importance of comprehensive mutational analysis of the entire mitochondrial genome when a mtDNA defect is strongly suggested.

Published
2006
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23. Involvement of brain opiate receptors in the immune-suppressive effect of morphine

Author

Robert Peter Gale, Yehuda Shavit, Antoine Depaulis, Fredricka C. Martin, Robert N. Pechnick, Cynthia J. Zane, Gregory W. Terman, and John C. Liebeskind

Subjects
Cytotoxicity, Immunologic, Male, Lymphocyte, Biology, Pharmacology, Natural killer cell, Immune system, medicine, Animals, Receptor, Multidisciplinary, Morphine, Antagonist, Brain, Naltrexone, Rats, Inbred F344, Rats, Killer Cells, Natural, medicine.anatomical_structure, Receptors, Opioid, Systemic administration, Opiate, Immunosuppressive Agents, Research Article, medicine.drug
Abstract

We previously reported that a single systemic injection of a high dose of morphine (greater than or equal to 20 mg/kg) transiently suppresses splenic natural killer cell cytotoxicity in rats. The present study examined the possibility that the immune-suppressive effect of morphine is mediated by opiate receptors in the brain. Supporting this hypothesis, we found that morphine (20 or 40 micrograms) injected into the lateral ventricle suppressed natural killer cell activity to the same degree as a systemic dose higher by three orders of magnitude. This effect was blocked by an opiate antagonist, naltrexone. Natural killer cell activity was unaffected by systemic administration of N-methyl morphine, a morphine analogue that does not cross the blood-brain barrier. These data implicate opiate receptors in the brain in morphine-induced suppression of natural killer cell cytotoxicity.

Published
1986
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25. Effects of footshock stress and morphine on natural killer lymphocytes in rats: studies of tolerance and cross-tolerance

Author

J.W. Lewis, John C. Liebeskind, Yehuda Shavit, Robert Peter Gale, Cynthia J. Zane, and Gregory W. Terman

Subjects
Cytotoxicity, Immunologic, medicine.medical_specialty, medicine.drug_class, Pharmacology, Naltrexone, Drug tolerance, Stress, Physiological, Internal medicine, medicine, Animals, Opioid peptide, Receptor, Molecular Biology, Electroshock, Morphine, business.industry, Foot, General Neuroscience, Brain, Drug Tolerance, Rats, Inbred F344, Rats, Cross-tolerance, Killer Cells, Natural, Endocrinology, Opioid, Receptors, Opioid, Female, Neurology (clinical), business, Opioid antagonist, Developmental Biology, medicine.drug
Abstract

Exposure to a form of footshock stress known to cause opioid-mediated analgesia suppresses the cytotoxic activity of natural killer (NK) cells in rats. This suppression is blocked by the opioid antagonist, naltrexone and is mimicked by morphine administration, suggesting mediation by opioid receptors. Supporting this hypothesis, we now report that the morphine-induced suppression of NK activity shows tolerance after 14 daily injections. The NK-suppressive effect of stress, however, shows neither tolerance with repetition nor cross-tolerance in morphine-tolerant rats.

Published
1986

26. How a Department of Laborâpproved benefit plan can make fringe pay work for you.

Author

Smith, J. Zane

Subjects
EMPLOYEE benefits, CONSTRUCTION contractors, TAX exemption, PAYROLL tax, PENSIONS
Abstract

The article discusses various issues related to a benefit plan approved by the U.S. Department of Labor that could add the taxes, unemployment, and payroll fees to the costs of the construction contractors in the U.S. Topics discussed include the ways to divert fringe pay of contractors into a tax-exempt bona fide benefit and pension plan for workers, jobs created due to the American Recovery & Reinvestment Act (ARRA), and benefits of the plan in terms of significant cost savings.

Published
2013

27. What the Fika ? Implementation of Swedish Coffee Breaks During Emergency Medicine Conference.

Author

Zane Kellar J, Barrett H, Floyd J, Kim M, Barden M, An J, Garispe A, and Hysell M

Subjects
Humans, Sweden, Male, Female, Adult, Sleepiness, Emergency Medicine education, Internship and Residency, Cross-Over Studies, Coffee
Abstract

Introduction: In this study we aimed to investigate the effects of incorporating Swedish-style fika (coffee) breaks into the didactic schedule of emergency medicine residents on their sleepiness levels during didactic sessions. Fika is a Swedish tradition that involves a deliberate decision to take a break during the workday and usually involves pastries and coffee. We used the Karolinska Sleepiness Scale to assess changes in sleepiness levels before and after the implementation of fika breaks., Methods: The study design involved a randomized crossover trial approach, with data collected from emergency medicine residents over a specific period. This approach was done to minimize confounding and to be statistically efficient., Results: Results revealed the average sleepiness scale was 4.6 and 5.5 on fika and control days, respectively ( P  = 0.004)., Conclusion: Integration of fika breaks positively influenced sleepiness levels, thus potentially enhancing the educational experience during residency didactics., Competing Interests: Conflicts of Interest: By the WestJEM article submission agreement, all authors are required to disclose all affiliations, funding sources and financial or management relationships that could be perceived as potential sources of bias. No author has professional or financial relationships with any companies that are relevant to this study. There are no conflicts of interest or sources of funding to declare.

Published
2024
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28. Factors Associated with Early Thrombosis after Arteriovenous Fistula Creation.

Author

Korn A, Alipour H, Zane J, Shahverdiani A, Ryan TJ, Kaji A, Bowens N, and de Virgilio C

Subjects
California epidemiology, Female, Graft Occlusion, Vascular diagnostic imaging, Graft Occlusion, Vascular physiopathology, Graft Occlusion, Vascular therapy, Hospitals, High-Volume, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Risk Factors, Thrombosis diagnostic imaging, Thrombosis physiopathology, Thrombosis therapy, Time Factors, Treatment Outcome, Vascular Patency, Arteriovenous Shunt, Surgical adverse effects, Graft Occlusion, Vascular epidemiology, Renal Dialysis, Thrombosis epidemiology
Abstract

Background: Arteriovenous fistulas (AVF) are the preferred modality for hemodialysis access. Early thrombosis hampers development of a working AVF. We endeavored to determine the incidence and identify factors associated with early thrombosis of AVF and to determine salvage rates following thrombosis, at a high-volume hemodialysis access center., Methods: Retrospective review of autologous AVF was created between November 2014 and July 2016 at a single center. Early thrombosis was defined as thrombosis that occurred within 30 days of surgery., Results: There were 291 AVFs. The median age was 54.7 years, and 192 patients (66%) were male. Early postoperative AVF thrombosis was noted in 5 (1.7%) cases. Factors associated with early thrombosis on univariate analysis included previous access surgery (P = 0.02) and absence of a good intraoperative thrill (P = 0.006). Intraoperative protamine use trended toward significance (P = 0.06). Factors that were not significant included gender, diabetes, dialysis at time of surgery, fistula configuration, and systemic heparin use. None of the thrombosed fistulas were salvaged., Conclusions: Early thrombosis is a relatively rare complication of AVF creation at a high-volume center. Previous access surgery and absence of good thrill at conclusion of the procedure are associated with early thrombosis., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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29. Ultrasound Vein and Artery Mapping by General Surgery Residents During Initial Consult Can Decrease Time to Dialysis Access Creation.

Author

Gray K, Korn A, Zane J, Gonzalez G, Kaji A, Bowens N, and de Virgilio C

Subjects
Arteries surgery, Education, Medical, Graduate, Female, Humans, Male, Middle Aged, Postoperative Complications etiology, Predictive Value of Tests, Referral and Consultation, Retrospective Studies, Risk Factors, Specialization, Time Factors, Time-to-Treatment, Treatment Outcome, Vascular Patency, Veins surgery, Workflow, Arteries diagnostic imaging, General Surgery education, Internship and Residency, Radiologists education, Renal Dialysis, Surgeons education, Ultrasonography, Upper Extremity blood supply, Veins diagnostic imaging
Abstract

Background: Formal preoperative ultrasound (US) mapping of vascular anatomy by radiology is recommended before hemodialysis access surgery. We hypothesized that US performed by general surgery residents in place of formal US would decrease the time from initial consult to creation of dialysis access without affecting patient outcomes., Methods: This is a retrospective review of all patients who underwent dialysis access surgery from November 2014 to July 2016 and received preoperative upper extremity US vein and artery evaluation by either radiology or general surgery residents. The primary endpoints were days from initial consult to dialysis access creation, rate of arteriovenous fistula (AVF) creation, fistula maturation, and 1-year primary assisted patency., Results: Of 242 patients, 167 (69%) had formal US, and 75 (31%) had only a resident US. The resident US group had 100% AVF creation compared with the formal US group with 92.2% AVF creation (P = 0.01). There was no difference between the groups in rate of fistula maturation (P = 0.1) and 1-year assisted patency (P = 0.9). Of the resident US 90.7% occurred in the outpatient setting. On multivariable analysis controlling for outpatient consult, the average time to the operating room was 13.7 days longer for the formal US group in the outpatient setting (P = 0.0006)., Conclusions: Ultrasound vein and artery evaluation at the time of the initial consult by general surgery residents can decrease the time to dialysis access creation by bypassing the need for formal US with a higher rate of AVF creation and no difference in fistula maturation or 1-year primary assisted patency., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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30. Preoperative Antibiotics for Dialysis Access Surgery: Are They Necessary?

Author

Gray K, Korn A, Zane J, Alipour H, Kaji A, Bowens N, and de Virgilio C

Subjects
California, Female, Humans, Male, Retrospective Studies, Risk Assessment, Risk Factors, Surgical Wound Infection diagnosis, Surgical Wound Infection microbiology, Treatment Outcome, Anti-Bacterial Agents administration & dosage, Antibiotic Prophylaxis, Arteriovenous Shunt, Surgical adverse effects, Blood Vessel Prosthesis Implantation adverse effects, Renal Dialysis, Surgical Wound Infection prevention & control, Unnecessary Procedures
Abstract

Background: Current guidelines recommend preoperative antibiotics in all vascular surgery cases. However, we hypothesize that patients undergoing arteriovenous fistula (AVF) and arteriovenous graft (AVG) creation have low rates of postoperative surgical site infection (SSI) and that preoperative antibiotic prophylaxis in these patients may not be necessary., Methods: This is a retrospective review of all patients who underwent AVF and AVG creation from November 2014 through July of 2016 at a single institution. At our institution, preoperative antibiotic use is surgeon dependent. Patients who received preoperative antibiotics were compared with those who did not. The primary outcome measured was the development of postoperative SSI., Results: There were 304 patients identified and 294 patients with 30 day postoperative follow-up. Of the 294 patients, 23 (7.8%) received an AVG, and 271 (92.2%) received an AVF. There were 244 (83%) patients who received preoperative antibiotics and 50 (17%) who did not. Overall, there were 2 (0.68%) SSIs identified. Both patients with postoperative SSI underwent AVF creation and received preoperative antibiotics. There was no statistically significant difference in SSI rate between antibiotic and nonantibiotic groups (P = 1.0), and no difference when comparing patients that received AVG (0%) and AVF (0.73%) (P = 1.0)., Conclusions: The rate for postoperative SSI following hemodialysis access surgery is very low both for patients undergoing AVF and AVG. Furthermore, there was no difference in SSI rate between antibiotic and nonantibiotic groups. Given these findings, we conclude that preoperative antibiotics for AVF creation may not be necessary., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Published
2018
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31. Predictors of Steal in Hemodialysis Access.

Author

Korn A, Alipour H, Zane J, Gray K, Ryan T, Kaji A, De Virgilio C, and Bowens N

Subjects
Adult, Aged, Female, Follow-Up Studies, Humans, Incidence, Ischemia diagnosis, Ischemia therapy, Logistic Models, Male, Middle Aged, Outcome Assessment, Health Care, Postoperative Complications diagnosis, Postoperative Complications therapy, Retrospective Studies, Risk Factors, Syndrome, Arteriovenous Shunt, Surgical adverse effects, Ischemia etiology, Postoperative Complications etiology, Renal Dialysis methods
Abstract

Pathological steal is an uncommon but devastating complication after the creation of arteriovenous access for hemodialysis. In this study, we sought to assess predictors of clinically significant steal syndrome and to further evaluate the outcome of differing surgical treatment approaches. A retrospective analysis was performed of 282 consecutive patients undergoing hemodialysis access at a single center from November 2014 to April 2016. Adequate follow-up to assess for the development of steal was obtained in 237 patients. One hundred and fifty-seven (66%) patients were male, 152 (64%) Hispanic, and 164 (69%) had diabetes. Forty-three (18%) had prior access procedures. Autologous fistula was created in 218 patients (92%). Pathologic steal occurred in 15 patients (6.7%). On univariate analysis, significant predictors of steal included female sex [P = 0.03, odds ratio (OR) = 3.3, CI [1.1-9]), no systemic heparin at operation (P = 0.02, OR = 5.0, CI [1.4-10]), use of angiotensin-converting enzyme inhibitor (P = 0.003, OR = 5.6, CI [1.7-18.6]), and increased vein size (3.1 vs 4.1 mm P = 0.01). Twelve patients had steal managed with an intervention, but only one patient received distal revascularization. Furthermore, we identify key predictors of clinically significant steal syndrome while demonstrating that distal revascularization and/or fistula ligation are rarely indicated treatment modalities.

Published
2017

32. Randomized trial of switching rheumatoid arthritis patients in remission with injectable gold to auranofin.

Author

Prete PE, Zane J, Krailo M, and Bulanowski M

Subjects
Administration, Oral, Arthritis, Rheumatoid diagnostic imaging, Arthritis, Rheumatoid physiopathology, Female, Humans, Injections, Intramuscular, Male, Patient Compliance, Prospective Studies, Radiography, Treatment Outcome, Arthritis, Rheumatoid drug therapy, Auranofin administration & dosage, Gold administration & dosage
Abstract

This prospective unblinded 24-month-study compared the therapeutic value of oral gold with injectable gold to maintain rheumatoid arthritis (RA) patients in clinical remission and prevent the progression of erosive disease. Forty-six patients with definite RA in remission with injectable gold were randomized into two groups: a control group, continued on maintenance injectable gold (Solganal, aurothioglucose, 50-100 mg, intramuscularly, 2 to 4 weeks); and an experimental group, switched to oral gold (6-9 mg auranofin by mouth daily). Only 29% of the original 24 oral gold patients remained on assigned treatment at 24 months compared with 64% of the injectable gold group. By six months, over one-half of the oral gold patients had electively stopped their randomized therapy. Sixty-seven percent of the oral gold patients had adverse reactions, mostly gastrointestinal complaints, compared with one proteinuria in the injectable gold group. The oral gold group experienced significantly more deterioration in all the primary measures of treatment effect over the follow-up period. At the termination of the trial, 88% of the group had increases of 5 or more points in radiographic scores suggesting progression of erosive disease compared with only 29% of the control group. These data suggest that oral gold is not an effective substitute for injectable gold in maintaining remission in rheumatoid arthritis.

Published
1994
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