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3 results on '"J-R Jourdain"'

1. Analysis of the distribution of MRI contrast agents in the livers of small animals by means of complementary microscopies

Author

Olivier Clément, Edmond Kahn, Guy Frija, Gérard Lizard, D. Coulaud, Nathalie Siauve, J.-R. Jourdain, Jean-Claude Bernengo, Frédérique Frouin, Charles-André Cuénod, Andrew Todd-Pokropek, Nicole Colas-Linhart, A. Petiet, Françoise Guiraud-Vitaux, C. Tessier, E. Delain, and C. Fourre

Subjects
Histology, Microscope, Materials science, Gadolinium, fungi, chemistry.chemical_element, Texas Red, Cell Biology, Fluorescence, Pathology and Forensic Medicine, law.invention, chemistry.chemical_compound, Nuclear magnetic resonance, chemistry, law, Confocal microscopy, Microscopy, Chelation, Europium
Abstract

Background: Magnetic resonance imaging (MRI) contrast agents contain magnetic molecules such as iron (Fe) or gadolinium (Gd) that are injected in vivo into rats or mice to study their distribution inside the liver. Fluorescent europium (Eu) can be used as a model of Gd to obtain comparable information of this distribution of corresponding contrast agents. In a similar approach, Fe can be attached to Texas Red and used as a model of ferumoxides and be detected by fluorescence. Methods: To combine and compare the advantages of different microscopic imaging modes, characterization studies were carried out by means of a confocal laser scanning microscope (CLSM), a secondary ion mass spectrometric (SIMS) microscope, and an electron energy loss spectrometric (EELS) microscope. In the case of CLSM, the locations of fluorescent signals inside preparations were determined by factor analysis of biomedical image sequences (FAMIS) and selection of image sequences at emission. Results: By CLSM and FAMIS, we distinguished chelated Eu and Texas Red attached to Fe. By SIMS microscopy, we distinguished Eu and Gd of chlorides and chelates and Fe of a ferumoxide. By EELS microscopy, we distinguished Eu and Gd of chlorides. Conclusions: Analysis of compounds inside correlative specimens by means of CLSM, SIMS, and EELS microscopes provided complementary results. Cytometry Part A 51A:97-106, 2003. (C) 2003 Wiley-Liss, Inc.

Published
2003

2. Analysis of the distribution of MRI contrast agents in the livers of small animals by means of complementary microscopies

Author

E, Kahn, C, Tessier, G, Lizard, A, Petiet, J-C, Bernengo, D, Coulaud, C, Fourré, F, Frouin, O, Clément, J-R, Jourdain, E, Delain, F, Guiraud-Vitaux, N, Colas-Linhart, N, Siauve, C-A, Cuenod, G, Frija, and A, Todd-Pokropek

Subjects
Mice, Inbred BALB C, Microscopy, Confocal, Iron, Contrast Media, Reproducibility of Results, Spectrometry, Mass, Secondary Ion, Gadolinium, Magnetic Resonance Imaging, Rats, Mice, Chlorides, Europium, Liver, Image Processing, Computer-Assisted, Animals, Female, Rats, Wistar, Fluorescent Dyes
Abstract

Magnetic resonance imaging (MRI) contrast agents contain magnetic molecules such as iron (Fe) or gadolinium (Gd) that are injected in vivo into rats or mice to study their distribution inside the liver. Fluorescent europium (Eu) can be used as a model of Gd to obtain comparable information of this distribution of corresponding contrast agents. In a similar approach, Fe can be attached to Texas Red and used as a model of ferumoxides and be detected by fluorescence.To combine and compare the advantages of different microscopic imaging modes, characterization studies were carried out by means of a confocal laser scanning microscope (CLSM), a secondary ion mass spectrometric (SIMS) microscope, and an electron energy loss spectrometric (EELS) microscope. In the case of CLSM, the locations of fluorescent signals inside preparations were determined by factor analysis of biomedical image sequences (FAMIS) and selection of image sequences at emission.By CLSM and FAMIS, we distinguished chelated Eu and Texas Red attached to Fe. By SIMS microscopy, we distinguished Eu and Gd of chlorides and chelates and Fe of a ferumoxide. By EELS microscopy, we distinguished Eu and Gd of chlorides.Analysis of compounds inside correlative specimens by means of CLSM, SIMS, and EELS microscopes provided complementary results.

Published
2003

3. Joint research towards a better radiation protection—highlights of the Fifth MELODI Workshop.

Author

A M Aerts, N R E N Impens, S Baatout, M A Benotmane, J Camps, J M Dabin, H Derradji, N Horemans, M Moreels, T Perko, R Quintens, L Struelens, F Hardeman, B Grosche, J-R Jourdain, J Repussard, W Rühm, and T Schneider

Subjects
RADIATION protection, RADIATION doses, FUKUSHIMA Nuclear Accident, Fukushima, Japan, 2011, RADIATION & the environment, RADIATION damage, CONFERENCES & conventions
Abstract

MELODI is the European platform dedicated to low-dose radiation risk research. From 7 October through 10 October 2013 the Fifth MELODI Workshop took place in Brussels, Belgium. The workshop offered the opportunity to 221 unique participants originating from 22 countries worldwide to update their knowledge and discuss radiation research issues through 118 oral and 44 poster presentations. In addition, the MELODI 2013 workshop was reaching out to the broader radiation protection community, rather than only the low-dose community, with contributions from the fields of radioecology, emergency and recovery preparedness, and dosimetry. In this review, we summarise the major scientific conclusions of the workshop, which are important to keep the MELODI strategic research agenda up-to-date and which will serve to establish a joint radiation protection research roadmap for the future. [ABSTRACT FROM AUTHOR]

Published
2014
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