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1. Surface damage on polycrystalline β-SiC by xenon ion irradiation at high fluence

Author

C. Bernard, N. Millard-Pinard, S. Gavarini, S. Cardinal, L. Escobar Sawa, Yann Leconte, B. Lanfant, Vincent Garnier, X. Jaurand, J. Baillet, C. Peaucelle, R. Rapegno, T. De Echave, A. Duranti, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Technologique des Microstructures (CTµ), Université de Lyon-Université de Lyon, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Edifices Nanométriques (LEDNA), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Rayonnement Matière de Saclay (IRAMIS), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
010302 applied physics, Nuclear and High Energy Physics, Materials science, Analytical chemistry, Oxide, Spark plasma sintering, chemistry.chemical_element, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, equipment and supplies, 021001 nanoscience & nanotechnology, 01 natural sciences, Fluence, Carbide, Ion, chemistry.chemical_compound, Xenon, Nuclear Energy and Engineering, chemistry, 0103 physical sciences, General Materials Science, Crystallite, Irradiation, 0210 nano-technology
Abstract

International audience; Nano-grained $\beta$-silicon carbide ($\beta$-SiC) pellets were prepared by Spark Plasma Sintering (SPS). These were implanted at room temperature with 800 keV xenon at ion fluences of 5.10$^{15}$ and 1.10$^{17}$ cm$^{-2}$. Microstructural modifications were studied by electronic microscopy (TEM and SEM) and xenon profiles were determined by Rutherford Backscattering Spectroscopy (RBS). A complete amorphization of the implanted area associated with a significant oxidation is observed for the highest fluence. Large xenon bubbles formed in the oxide phase are responsible of surface swelling. No significant gas release has been measured up to 10$^{17}$ at.cm$^{-2}$. A model is proposed to explain the different steps of the oxidation process and xenon bubbles formation as a function of ion fluence.

Published
2018
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2. Effects of helium irradiation on fine grained β-SiC synthesized by spark plasma sintering

Author

B. Lanfant, C. Peaucelle, S. Gavarini, S. Cardinal, Vincent Garnier, X. Jaurand, C. Bernard, Charline Dalverny, Yann Leconte, N. Millard-Pinard, R. Rapegno, J. Baillet, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Technologique des Microstructures (CTµ), Université de Lyon-Université de Lyon, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Laboratoire Edifices Nanométriques (LEDNA), Nanosciences et Innovation pour les Matériaux, la Biomédecine et l'Energie (ex SIS2M) (NIMBE UMR 3685), Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Institut Rayonnement Matière de Saclay (IRAMIS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

Subjects
010302 applied physics, Materials science, Ion beam analysis, Analytical chemistry, Spark plasma sintering, chemistry.chemical_element, 02 engineering and technology, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, Fluence, chemistry.chemical_compound, chemistry, Nuclear reaction analysis, visual_art, 0103 physical sciences, Materials Chemistry, Ceramics and Composites, Silicon carbide, visual_art.visual_art_medium, Irradiation, Ceramic, 0210 nano-technology, Helium
Abstract

International audience; Silicon carbide has a high resistance to irradiation making it a material of choice for use in the nuclear reactors. In this work, we focus on experiments involving implantation of 30 keV 3He ions at room temperature (RT) in sintered β-SiC. Helium is produced in large quantities in fission and fusion reactors, and its accumulation in materials can lead to the formation of bubbles. The irradiation induces structural modifications within the material that can be coupled with changes in composition, especially at high fluence. Three ion fluencies are used here: 5 × 1015, 1 × 1017and 1 × 1018at. cm−2. Structural damages are studied by electron microscopy and helium profiles are measured by nuclear reaction analysis (NRA). At 1 × 1018 at. cm−2, helium bubbles are formed in the implanted zone, which also undergoes strong oxidation. Surface blisters are also observed and helium concentration threshold for bubble formation is estimated to about 4 at. % by correlating the MET observations with the results obtained by ion beam analysis. For the highest fluence, a residual concentration of 3.6 × 1017 at. cm−2 was measured just after implantation (instead of 1 × 1018 at. cm−2), which indicates a significant release of helium by the material during the process. The link between the microstructural evolution of the material, its progressive oxidation under beam and the release of helium is discussed. The very likely role played by the porosity on the oxidation of the material under irradiation at RT is underlined. Finally, the results obtained here on silicon carbide are compared with those obtained on another ceramic (TiC) which does not amorphize in similar conditions.

Published
2019
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3. Elaboration and behavior under extreme irradiation conditions of nano- and micro-structured TiC

Author

S. Gavarini, M. Gherrab, Vincent Garnier, Thierry Douillard, N. Millard-Pinard, X. Jaurand, J. Baillet, L. Dernoncourt, C. Peaucelle, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre Technologique des Microstructures (CTµ), Université de Lyon-Université de Lyon, Consortium Lyon Saint-Etienne de Microscopie (CLYM), École normale supérieure - Lyon (ENS Lyon)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet [Saint-Étienne] (UJM), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-École Centrale de Lyon (ECL), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)

Subjects
010302 applied physics, Nuclear and High Energy Physics, Materials science, Titanium carbide, Metallurgy, Spark plasma sintering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Grain size, Carbide, chemistry.chemical_compound, chemistry, 0103 physical sciences, Surface roughness, Grain boundary, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph], Irradiation, Composite material, 0210 nano-technology, Instrumentation
Abstract

International audience; Titanium carbide samples were prepared by spark plasma sintering. Three different microstructures were prepared with average grain sizes of about 0.3, 1.3 and 25.0 μm. Each microstructure was irradiated with either 500 keV 40Ar+ ions or 800 keV 129Xe++ ions. The irradiation fluence varied from 6 × 1016 to 3.2 × 1017 at.cm−2. Irradiation was carried out at room temperature (RT) or at 1000 °C. Post-irradiation annealing was performed on some samples to follow the surface modification. In fact, clusters and nanocracks were observed at depth in the nanometric grains (1 μm). Microcracks can induce localized surface blistering after irradiation at RT and for the highest fluencies. The size, shape and density of the blisters were proposed to depend on the crystallographic orientation of each grain. The microstructure with sub-micrometric grains exhibited increased surface roughness after irradiation, with grain removal and grain boundary abrasion but no blistering. Surface blistering is not observed after irradiation at 1000 °C but the complete delamination of extended areas containing large grains occurs. In this article, we highlight the role played by gastight grain boundaries and porosity to explain the distinct behavior of microstructures.

Published
2015
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4. Influence of grain size and microstructure on oxidation rate and mechanism in sintered titanium carbide under high temperature and low oxygen partial pressure

Author

C. Peaucelle, L. Dernoncourt, R. Rapegno, S. Cardinal, N. Millard-Pinard, J. Baillet, C. Bernard, T. De Echave, X. Jaurand, S. Gavarini, A. Duranti, Vincent Garnier, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Centre Technologique des Microstructures (CTµ), Université de Lyon-Université de Lyon, Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010302 applied physics, Materials science, Titanium carbide, Metallurgy, Oxide, 02 engineering and technology, Thermal treatment, Partial pressure, 021001 nanoscience & nanotechnology, Microstructure, 01 natural sciences, Grain size, Carbide, chemistry.chemical_compound, chemistry, Chemical engineering, 0103 physical sciences, Materials Chemistry, Ceramics and Composites, Grain boundary, 0210 nano-technology, [CHIM.RADIO]Chemical Sciences/Radiochemistry, ComputingMilieux_MISCELLANEOUS
Abstract

Titanium carbide (TiC) pellets were prepared by Spark Plasma Sintering (SPS). Three different microstructures were synthesized with average grain sizes of 340 nm, 1.34 μm and 25 μm, respectively. Prior to oxidation treatment, TiC samples were implanted with xenon ions. This noble gas is used as a marker of the initial surface. Oxidation behavior was studied by Rutherford Backscattering Spectroscopy (RBS) and electronic microscopy through thermal treatment at 1000 °C for 10 h and under different low oxygen partial pressure (OPP). No detectable oxidation was observed after thermal treatment at OPP ≤ 2.10−7 mbar whereas an oxide layer is formed at OPP = 2.10−6 mbar. Thickness, composition and morphology of the oxide layer depend on the initial microstructure of the material. Numerous grain boundaries and the porosity (≈10%) of the nano-grained material were responsible for the enhanced penetration of oxygen which resulted in the formation of a thick oxide layer. This layer is composed of external oxide and interfacial band sublayers. Ti4O7 was identified by XRD (X-Ray Diffraction) as being the main phase in the oxide layer concerning the nano-grained material whereas a relatively thick layer of TiO2 (rutile) is formed for larger grain microstructures. We proved the presence of carbon in the interfacial band as well as possible evacuation paths for CO/CO2 gas. There is less release of xenon from nano-grained material than larger grained materials during oxidation at OPP = 2.10−6 mbar for 20 h attesting to the superior gas-tightness of the oxide layer in this case. A schematic model is then proposed to explain growth mechanisms and properties of the oxide layer.

Published
2016
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5. Structural modifications induced by ion irradiation and temperature in boron carbide B$_4$C

Author

Sandrine Miro, J. Baillet, Dominique Gosset, Guillaume Victor, Nikolay Djourelov, Nathalie Moncoffre, N. Toulhoat, N. Bérerd, Alexandre Maitre, Y. Pipon, Nicolas Pradeilles, Olivier Rapaud, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Lab JANNUS, Service de recherches de métallurgie physique (SRMP), Département des Matériaux pour le Nucléaire (DMN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Département des Matériaux pour le Nucléaire (DMN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Axe 4 : céramiques sous contraintes environnementales (SPCTS-AXE4), Science des Procédés Céramiques et de Traitements de Surface (SPCTS), Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM), Service des Recherches Métallurgiques Appliquées (SRMA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Institut de Recherche sur les CERamiques (IRCER), Institut de Chimie du CNRS (INC)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Service des Réacteurs et de Mathématiques Appliquées (SERMA), Département de Modélisation des Systèmes et Structures (DM2S), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Ecole Nationale Supérieure de Céramique Industrielle (ENSCI)-Institut des Procédés Appliqués aux Matériaux (IPAM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Service d’Études des Réacteurs et de Mathématiques Appliquées (SERMA), and Flores, Sylvie

Subjects
Nuclear and High Energy Physics, Materials science, Neutron poison, Analytical chemistry, Spark plasma sintering, 02 engineering and technology, Boron carbide, 7. Clean energy, 01 natural sciences, Ion, chemistry.chemical_compound, 0103 physical sciences, Neutron, Irradiation, Instrumentation, Raman, Structural defects, ComputingMilieux_MISCELLANEOUS, 010302 applied physics, [PHYS]Physics [physics], [CHIM.MATE] Chemical Sciences/Material chemistry, Radiochemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Slow positron, chemistry, Annihilation radiation, 0210 nano-technology, Doppler broadening
Abstract

Already used as neutron absorber in the current French nuclear reactors, boron carbide (B 4 C) is also considered in the future Sodium Fast Reactors of the next generation (Gen IV). Due to severe irradiation conditions occurring in these reactors, it is of primary importance that this material presents a high structural resistance under irradiation, both in the ballistic and electronic damage regimes. Previous works have shown an important structural resistance of boron carbide even at high neutron fluences. Nevertheless, the structural modification mechanisms due to irradiation are not well understood. Therefore the aim of this paper is to study structural modifications induced in B 4 C samples in different damage regimes. The boron carbide pellets were shaped and sintered by using spark plasma sintering method. They were then irradiated in several conditions at room temperature or 800 °C, either by favoring the creation of ballistic damage (between 1 and 3 dpa), or by favoring the electronic excitations using 100 MeV swift iodine ions ( S e ≈ 15 keV/nm). Ex situ micro-Raman spectroscopy and Doppler broadening of annihilation radiation technique with variable energy slow positrons were coupled to follow the evolution of the B 4 C structure under irradiation.

Published
2014
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6. Place du tubage biliaire dans le diagnostic des pancréatites aiguës sans étiologie retrouvée

Author

J.P. Ducroix, B Lafon, Amar Smail, and J. Baillet

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, Internal Medicine, Medicine, business
Abstract

Resume Le tubage biliaire intervient dans le diagnostic etiologique des pancreatites aigues lorsque la cause n'est retrouvee ni par l'anamnese, l'examen clinique, les echographies abdominales ou la cholangiographie retrograde. L'etiologie apparait alors liee a la presence de microcristaux biliaires dans 40% des cas. Les microcristaux peuvent etre du monohydrate de cholesterol, du bilirubinate de calcium ou des microspherolithes. Leur seule presence incite a la cholecystectomie pour eviter les recidives de pancreatite aigue.

Published
1994
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7. Pathology

Author

L. I. Aruin, D. S. Sarkisov, O. A. Lisenco, H. O’Connor, K. Cunnane, D. M. M. Queiroz, E. N. Mendes, G. A. Rocha, S. B. Moura, L. M. H. Resende, J. R. Cunha-Melo, A. S. T. Carvalho, L. G. V. Coelho, M. C. G. Passos, L. P. Castro, C. A. Oliveira, G. F. Lima, A. J. A. Barbosa, M. C. F. Passos, P. Castro, Gianni Testino, A. Perasso, D. Boixeda, C. Martín de Argila, T. Vila, C. Redondo, R. Cantón, C. Avila, I. Alvarez-Baleriola, L. de Rafael, E. M. Witteman, M. C. J. M. Becx, R. W. De Koning, J. C. P. Silva, A. M. M. F. Nogueira, E. Paulino, C. R. Miranda, A. Rudelli, G. Vialette, H. Sevestre, D. Capron, J. P. Ducroix, A. Smail, J. Baillet, F. Zerbib, P. L. Seurat, P. Sauvet, D. Bechade, N. Rapp, J. S. Peacock, P. Marchildon, F. Zamaniyan, J. Bond-Green, P. Liu, L. Ciota, A. Lee, N. Coltro, M. Chen, M. Alhomsi, E. Adeyemi, C. S. Goodwin, C. Rizzi, R. Maieron, L. Desinan, C. Avellini, G. L. Da Broi, C. A. Beltrami, G. Proto, F. Grimaldi, A. Proietti, C. A. Scott, S. Takasashi, H. Igarshi, N. Ishiyama, K. Nakamura, N. Masubuchi, M. Ozaki, S. Saito, T. Aoyagi, T. Itoh, I. Hirata, T. Matysiak-Budnik, E. Poniewierka, G. Gasciniak, M. Jelen, Z. Knapik, G. Gosciniak, W. M. Neri, D. Susi, I. Bovani, F. Laterza, F. Cuccurullo, A. Amorosi, P. Bechi, R. Dei, R. Mazzanti, D. A. F. Lynch, G. M. Sobala, A. Gledhill, P. Jackson, J. E. Crabtree, P. N. Foster, A. T. R. Axon, M. F. Dixon, H. I. Maaroos, P. Sipponen, M. Kekki, M. G. Di Bello, S. Raspanti, T. Vardar, F. J. Sancho, E. Olivia, S. Saiz, J. Pons Mones, Craig Hood, Milena Lesna, Ruth Alcolado, T. Knitht, S. Greaves, A. Wilson, M. Corlett, P. Webb, J. Wyatt, D. Newell, K. Hengels, D. Forman, J. B. Elder, F. Farinati, R. Cardin, F. Valiante, G. Delia Libera, M. Plebani, M. Rugge, R. Baffa, M. Guido, F. Di Mario, R. Naccarato, J. Gilvarry, E. Leen, S. Sant, E. Sweeney, C. O’ Morain, J. Schönlebe, H. Riedel, M. Prinz, L. Hahn, H. Porst, H. Lohmann, E. Orsini, J. Guerre, M. Tulliez, S. Chaussade, M. Gaudric, R. Canton, J. Sampedro, A. García-Plaza, P. Cognein, M. C. Parodi, A. Tucci, S. Gasperoni, V. Stanghellini, C. Tosetti, G. F. Paparo, O. Varoli, S. Siringo, R. Santucci, N. Monetti, G. Barbara, R. Corinaldesi, P. Dotto, F. Vianello, Ferrana M., G. A. Grasso, T. Del Bianco, G. Laino, B. Germanà, G Battaglia, C. K. Axelson, L. P. Andersen, P. B. Szecsi, K. N. Olsen, C. J. Lundborg, C. Andre, L. Descos, A. Martin, S. Cavagna, M P. Brassens-Rabbé, S. Wu, T. Wadström, F. Mégraud, G. Perdichizzi, L. Muratori, S. Pallio, M. Bottair, M. T. Fera, E. Quattrocchi, V. Caruso, T. Karttunen, T. Kerola, R. Kartttunen, S. Niemelä, T. U. Kosunen, F. Bonchviam, S. Pretolani, M. Baraldine, D. Cilla, S. Baldinelli, and G. Gasparrini

Subjects
03 medical and health sciences, Pathology, medicine.medical_specialty, 0302 clinical medicine, business.industry, medicine, 030212 general & internal medicine, General Medicine, 030204 cardiovascular system & hematology, business
Published
1992
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8. Pharmacokinetics and ascitic fluid penetration of piperacillin in cirrhosis

Author

J. P. Ducroix, A. Smail, J. Baillet, Michel Andrejak, and L. Hary

Subjects
Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Gastroenterology, Pharmacokinetics, Liver Cirrhosis, Alcoholic, Internal medicine, Ascites, medicine, Ascitic Fluid, Humans, Pharmacology (medical), Infusions, Intravenous, Chromatography, High Pressure Liquid, Piperacillin, Pharmacology, business.industry, Peritoneal fluid, Half-life, Middle Aged, medicine.disease, Surgery, Penicillin, Female, Biological half-life, medicine.symptom, business, medicine.drug
Abstract

The pharmacokinetics of piperacillin were evaluated in seven healthy volunteers, eight cirrhotic patients without ascites and 11 cirrhotic patients with sterile ascites after a single 15-min intravenous infusion of 4 g of the drug. In ascitic patients, piperacillin rapidly entered the peritoneal fluid. Peritoneal concentrations were higher than 10 mg/l from 0.5 to 8 h after the infusion. Disappearance rate of piperacillin was slower in the ascitic fluid than in plasma. The plasma half life of piperacillin was more prolonged in cirrhotic patients that in control subjects. This difference was more marked in ascitic patients for whom half life was twice as high as in volunteers (1.95 versus 0.91 h; P less than 0.01).

Published
1991
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11. [Subjectivity in the reading of scientific articles]

Author

J, Baillet

Subjects
Affect, Review Literature as Topic, Reading, Emotions, Humans
Abstract

With the examples of historical incoherencies in the diagnosis and treatment of myocardial infarction and pulmonary embolism, the author shows that it is not easy to be an objective reader of "good" scientific articles. Our neuropsychological mechanisms do not facilitate an "intelligent" attitude without the aid of affectivity. An unwanted thymotic component places the reader in an ambiguous position with respect to authority and reality. Though one can never know too much, it is difficult, alone, to maintain an intelligent curiosity. Some financial interests may awaken it. During his career, the physician has to navigate between two slightly contradictory necessities: changing his attitude with respect to new information, and according credence to his personal experience.

Published
1994

12. [Role of biliary intubation in the diagnosis of acute pancreatitis without known etiology]

Author

B, Lafon, A, Smail, J P, Ducroix, and J, Baillet

Subjects
Microscopy, Pancreatitis, Acute Disease, Bile, Humans, Crystallization, Intubation, Gastrointestinal
Abstract

Biliary tubage, is interesting in the aetiological research of acute pancreatitis, when the origin is unknown after anamnesis, clinical examination, abdominal ultrasonographic studies and retrograde cholangiography. The sludge is the aetiology fond in 40% of the cases. Microscopic crystals are either cholesterol monohydrate, either calcium bilirubinate, or calcium carbonate microspheroliths. Biliary microscopic crystals drive the patients to the cholecystectomy to prevent acute pancreatitis relapses.

Published
1994

13. [Presymptomatic detection of familial colonic polyposis]

Author

J P, Ducroix, C, Lenaerts, S, Milazzo, J L, Dupas, S, Olschwang, B, Lafont, A, Smail, J, Baillet, and C, Puissan

Subjects
Adult, Genetic Markers, Adenomatous Polyposis Coli, Humans, Hypertrophy, Child, Pigment Epithelium of Eye
Abstract

In familial adenomatous polyposis coli (APC) it is possible to detect APC carriers either by research of bilateral congenital hypertrophy of the retinal pigment epithelium (CHRPE) or by genetic diagnosis (APC gene is localized in 5q21). These detections were performed in 33 patients of four families with the same positivity for genetic typing (11 patients) or for CHRPE (11 patients) which thus avoided annual coloscopy.

Published
1993

14. [Pneumopathies caused by Chlamydia pneumoniae]

Author

J P, Bruaire, J P, Ducroix, F, Eb, A, Smail, G, Cohen, J, Orfila, and J, Baillet

Subjects
Male, Roxithromycin, Fluorescent Antibody Technique, Pneumonia, Azithromycin, Chlamydia Infections, Chlamydophila pneumoniae, Middle Aged, Erythromycin, Humans, Female, Serologic Tests, Prospective Studies, Aged
Abstract

Among the atypical pneumonias observed between March 1990 and March 1991, 6 were diagnosed as being caused by Chlamydia pneumoniae of the TWAR strain. The serological diagnosis was obtained by a microimmunofluorescence test. All 6 patients had anti-TWAR antibody levels higher than 512; they were treated with a macrolide administered by the oral route and were cured without sequelae or recurrences. Four cases received a ten day course of roxithromycin 300 mg/day and one case received erythromycin 2 g/day also for 10 days. The sixth case received a short course of azithromycin 500 mg once daily for three days. In 2 other patients presenting with clinical and radiological signs of pneumonia the diagnosis of C. pneumoniae infection could not be made despite an antibody level equal or higher than 512, since the serological results showed cross-reactions between C. pneumoniae, C. trachomatis and C. psittaci antibody responses.

Published
1992

15. [Pulmonary metastasis of meningioma of the falx cerebri]

Author

N, Hamant, J P, Ducroix, H, Sevestre, M, Daurat, P, Toussaint, A, Smail, G, Cohen, M F, Gontier, and J, Baillet

Subjects
Adult, Lung Neoplasms, Neoplasm Seeding, Brain Neoplasms, Meningeal Neoplasms, Humans, Female, Neoplasm Recurrence, Local, Meningioma
Abstract

We report the case of a woman who had been operated upon for a recurrent meningioma of the falx cerebri which, 22 years after it was discovered, produced pulmonary metastases. Metastases from meningiomas are extremely rare; they affect the lungs in 60% of the cases or, less frequently, the liver or lymph nodes. The factors predictive of secondary dissemination are the site of the tumour, the quality of excision, the histological type (haemangiopericytic meningioma) and the presence of cell necrosis, hypercellularity and strong mitotic activity.

Published
1992

16. [Yersinia enterocolitica infection. Apropos of a case with cervical localization]

Author

V, Strunski, A B, Maakaraoun, J P, Ducroix, F, Eb, and J, Baillet

Subjects
Aged, 80 and over, Male, Yersinia Infections, Humans, Tomography, X-Ray Computed, Abscess, Neck, Aged, Yersinia enterocolitica
Abstract

The authors report a case of cervical abscess due to yersinia enterocolitica. This is a currently exceptional localization of an enteropozoonosis which is little-known, but whose incidence is increasing throughout the world.

Published
1991

17. [Clinical and pharmacokinetic study of pefloxacin in spontaneous ascitic fluid infections]

Author

J P, Ducroix, L, Hary, M, Andrejak, A, Smail, A, Tondriaux, F, Eb, and J, Baillet

Subjects
Adult, Aged, 80 and over, Male, Liver Cirrhosis, Alcoholic, Ascitic Fluid, Humans, Female, Bacterial Infections, Middle Aged, Pefloxacin, Aged
Abstract

Ten patients with spontaneous ascitic fluid infections received intravenously 400 mg of pefloxacin for pharmacokinetic evaluation of the drug and its diffusion into peritoneal space. The patients were then treated with oral pefloxacin (400 mg every 36 h except for icteric patients: 48 h) during 21 days. Total body clearance was decreased (0.66 +/- 0.16 ml/min/kg) and elimination half life was increased as compared to that observed in normal subject (28.2 +/- 7.6 h), the longest half-lives being observed in the cases with the most severe alteration of hepatic function. Peritoneal concentrations were higher than 1 microgram/ml (i.e. exceeding the minimal inhibitory concentrations for most of the bacterial species involved in ascitic fluid infections) from the first half-hour after infusion to at least 36 hours. 9 of the 10 cases were cured. Pefloxacin provided a well spaced rythm of administration is a suitable antibacterial drug for ascitic fluid infections in cirrhotic patients with two advantages: its effectiveness against Enterobacteriaceae and an oral administration.

Published
1990

18. [Genital sites of giant-cell arteritis]

Author

J P, Ducroix, H, Sevestre, G, Humbert, A, Smail, G, Cohen, Hoang-Ngoc Minh, T M, Palliez, and J, Baillet

Subjects
Ovarian Cysts, Leiomyoma, Giant Cell Arteritis, Uterine Neoplasms, Humans, Female, Genitalia, Female, Middle Aged, Aged
Abstract

Temporal arteritis is one of the localisation of the giant cell arteritis. The involvement of the female genital tract had been rarely reported with only 16 cases in the literature. We report 3 cases revealed by a tumor of the genital tract. Histologic features are found in the vessels of ovaries, fallopian tubes and myometrium. Only one patient had symptoms suggestive of temporal arteritis.

Published
1990

19. [Multiple duodenal lipomas. A x-ray computed tomographic diagnosis]

Author

J, Delamarre, G, Cohen, C, Jouet-Gondry, J P, Ducroix, B, Deschepper, V, Fabre, and J, Baillet

Subjects
Male, Duodenal Neoplasms, Humans, Lipomatosis, Tomography, X-Ray Computed, Aged
Abstract

In a 65-year-old man, upper endoscopy revealed several polypoid lesions into the duodenum, for which histologic examination of the biopsy specimens showed normal mucosa. CT studies demonstrated homogeneous fat density of these nodules, and thus were diagnostic of duodenal lipomas. The diagnosis was ultimately histologically confirmed by deeper peri-endoscopic biopsies. About this case and the some previously reported ones, the authors emphasize the interest of CT examination in this small bowel tumor.

Published
1990

22. Hypertension artérielle pulmonaire primitive: un mode rare de révélation du sida. À propos d'une observation

Author

J. Baillet, A. Rudelli, B Lafon, J.-P. Ducroix, A. Duché, Amar Smail, and M.-P. Guillaumont

Subjects
Gynecology, medicine.medical_specialty, biology, business.industry, Gastroenterology, Human immunodeficiency virus (HIV), medicine.disease_cause, biology.organism_classification, medicine.disease, Acquired immunodeficiency syndrome (AIDS), Immunopathology, Internal Medicine, medicine, Viral disease, Sida, business
Published
1996
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37. Pneumopathies à Chlamydia pneumoniae

Author

J Orfila, J.-P. Ducroix, J. Baillet, N Lafon, I Leduc, A Small, F. Eb, and A Gérard

Subjects
Chlamydia, Gastroenterology, Internal Medicine, medicine, medicine.disease, Microbiology
Published
1995
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42. Intérêt de la contre-immunoélectrophorèse dans le diagnostic de la brucellose

Author

A. Rudelli, D. Ursu, A. Audurier, Amar Smail, J.P. Ducroix, and J. Baillet

Subjects
Gynecology, medicine.medical_specialty, business.industry, Gastroenterology, Internal Medicine, Medicine, business, Serology, Human brucellosis
Abstract

We describe through ten cases the interest of counter immuno-electrophoresis with other serological tests in the diagnosis of human brucellosis.

Published
1993
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43. Dépistage présymptomatique de la polypose colique familiale

Author

C. Lenaerts, S. Milazzo, J.L. Dupas, Sylviane Olschwang, J. Baillet, Amar Smail, Puissan C, J.P. Ducroix, and Lafont B

Subjects
Pathology, medicine.medical_specialty, Retinal pigment epithelium, business.industry, Gastroenterology, Genetic typing, medicine.anatomical_structure, Congenital hypertrophy, Internal Medicine, Medicine, Familial Adenomatous Polyposis Coli, business, Genetic diagnosis, Gene
Abstract

In familial adenomatous polyposis coli (APC) it is possible to detect APC carriers either by research of bilateral congenital hypertrophy of the retinal pigment epithelium (CHRPE) or by genetic diagnosis (APC gene is localized in 5q21). These detections were performed in 33 patients of four families with the same positivity for genetic typing (11 patients) or for CHRPE (11 patients) which thus avoided annual coloscopy.

Published
1993
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44. P 013 Bowel perforation in the course of Behçet's disease

Author

J.P. Ducroix, J. Baillet, H. Sevestre, A. Rudelli, Amar Smail, Henry X, and D. Ursu

Subjects
medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, Internal Medicine, medicine, Behcet's disease, Bowel perforation, medicine.disease, business
Published
1993
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45. Sténose colique et urétérale: complications d'une pancréatite aiguë

Author

R. Delcenserie, J.P. Ducroix, Ph. Levy, G. Morin, J. Baillet, Amar Smail, and A. Rudelli

Subjects
medicine.medical_specialty, urogenital system, business.industry, Gastroenterology, Ureteral stenosis, urologic and male genital diseases, Colonic Stenosis, medicine.disease, digestive system diseases, female genital diseases and pregnancy complications, surgical procedures, operative, Internal Medicine, medicine, Acute pancreatitis, Radiology, business, Complication
Abstract

We report two cases of rare complication of acute pancreatitis: colonic stenosis and ureteral stenosis.

Published
1992
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46. La néphrite aiguë bactérienne et focale chez l'adulte

Author

Amar Smail, J. Baillet, J.P. Ducroix, H. Abourachid, and F. Dahmani

Subjects
Pathology, medicine.medical_specialty, business.industry, Immunology, Gastroenterology, Internal Medicine, Medicine, Disease, business, Bacterial nephritis
Abstract

We studied a serial of twelve patients suffering from a renal inflammatory disease or acute bacterial nephritis. We show the advantage of C.T.scan.

Published
1992
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47. Gastrite folliculaire et Helicobacter pylori

Author

J. Baillet, J.P. Ducroix, Amar Smail, G. Vialette, Ph. Levy, A. Rudelli, and D. Capron

Subjects
medicine.medical_specialty, education.field_of_study, Helicobacter pylori infection, biology, business.industry, Population, Gastroenterology, Helicobacter pylori, bacterial infections and mycoses, biology.organism_classification, Antral gastritis, Internal medicine, Internal Medicine, Medicine, Gastritis, medicine.symptom, Young adult, business, education
Abstract

It has been recently suggested that histolocical findings of antral gastritis (FG) were associated with Helicobacter pylori infection. The aim of this study was to assess the connection between FG and Helicobacter pylori associated gastritis in a young adult population.

Published
1992
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48. Uvéite en médecine interne

Author

C. Freville, A. Khereddine, Amar Smail, A. Rudelli, P. Hue, C. Le Fouille-Ribeyre, J. Baillet, and J.P. Ducroix

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Retrospective cohort study, Disease, medicine.disease, Dermatology, humanities, Surgery, Infectious disease (medical specialty), Internal Medicine, Medicine, business, Uveitis
Abstract

A retrospective study was conducted in 42 patients with uveitis. In 21 % of patients in the present report associated system disease one or more were found. Infectious disease are frequent. Complete investigation are necessary.

Published
1992
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49. Infection à Mycoplasma pneumoniae chez l'adulte. À propos d'une étude sur six ans au C.H.U. d'Amiens

Author

C. Le Fouille-Ribeyre, C. Freville, P. Hue, A. Rudelli, J. Baillet, J.P. Ducroix, and Amar Smail

Subjects
Mycoplasma pneumoniae, medicine.drug_class, business.industry, Antibiotics, Gastroenterology, medicine.disease_cause, medicine.disease, Virology, respiratory tract diseases, Microbiology, Mycoplasma pneumonia, Internal Medicine, medicine, business
Abstract

Diagnosis of infection caused by Mycoplasma pneumoniae in adult. A study in Amiens. A report of 33 cas by Mycoplasma pneumonia are notified, in particular uncommon presentation : central nervous system complications and community acquired pneumoniae. We report the current status of antibiotic treatment for Mycoplasma pneumoniae infection and evolution with these antibiotic.

Published
1992
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50. Résonance magnétique nucléaire et spondylodiscite

Author

C. Le Fouille-Ribeyre, C. Gondry, P. Toussaint, Amar Smail, J. Delcour, K. Masmoudi, J.P. Ducroix, A. Rudelli, J.L. Sebert, and J. Baillet

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Gastroenterology, Internal Medicine, medicine, Vertebral osteomyelitis, Magnetic resonance imaging, Radiology, equipment and supplies, business, medicine.disease, human activities
Abstract

Magnetic resonance imaging permits an early diagnosis in vertebral osteomyelitis but puncture of the disc for bacteriological examination remains an indication of the C.T. scan.

Published
1992
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