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5. Locally advanced pancreatic cancer: Work-up, staging, and local intervention strategies

Author

Eran van Veldhuisen, Claudia van den Oord, Lilly J. Brada, Marieke S. Walma, Jantien A. Vogel, Johanna W. Wilmink, Marco del Chiaro, Krijn P. van Lienden, Martijn R. Meijerink, Geertjan van Tienhoven, Thilo Hackert, Christopher L. Wolfgang, Hjalmar van Santvoort, Bas Groot Koerkamp, Olivier R. Busch, I. Quintus Molenaar, Casper H. van Eijck, Marc G. Besselink, the Dutch Pancreatic Cancer Group and International Collaborative Group on Locally Advanced Pancreatic Cancer, and Surgery

Subjects
medicine.medical_specialty, Cancer Research, Radiofrequency ablation, FOLFIRINOX, medicine.medical_treatment, Review, ablation, lcsh:RC254-282, law.invention, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, law, Pancreatic cancer, medicine, Journal Article, resection, Chemotherapy, business.industry, Induction chemotherapy, Explorative laparotomy, Irreversible electroporation, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, locally advanced pancreatic cancer, Work-up, Oncology, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Radiology, business, explorative laparotomy
Abstract

Locally advanced pancreatic cancer (LAPC) has several definitions but essentially is a nonmetastasized pancreatic cancer, in which upfront resection is considered not beneficial due to extensive vascular involvement and consequent high chance of a nonradical resection. The introduction of FOLFIRINOX chemotherapy and gemcitabine-nab-paclitaxel (gem-nab) has had major implications for the management and outcome of patients with LAPC. After 4–6 months induction chemotherapy, the majority of patients have stable disease or even tumor-regression. Of these, 12 to 35% are successfully downstaged to resectable disease. Several studies have reported a 30–35 months overall survival after resection; although it currently remains unclear if this is a result of the resection or the good response to chemotherapy. Following chemotherapy, selection of patients for resection is difficult, as contrast-enhanced computed-tomography (CT) scan is unreliable in differentiating between viable tumor and fibrosis. In case a resection is not considered possible but stable disease is observed, local ablative techniques are being studied, such as irreversible electroporation, radiofrequency ablation, and stereotactic body radiation therapy. Pragmatic, multicenter, randomized studies will ultimately have to confirm the exact role of both surgical exploration and ablation in these patients. Since evidence-based guidelines for the management of LAPC are lacking, this review proposes a standardized approach for the treatment of LAPC based on the best available evidence.

Published
2019
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6. Abstracts

Author

O. Barthelemy, J. Silvain, D. Brieger, A. Bellemain-Appaix, G. Cayla, F. Beygui, R. Lancar, J. P. Collet, A. Mercadier, G. Montalescot, K. S. Cha, Y. H. Nam, J. H. Kim, S. Y. Park, T. H. Park, M. H. Kim, Y. D. Kim, H. C. Lee, M. S. Ahn, T. J. Hong, R. Blanco, F. Blanco, J. Szarfer, A. Garcia Escudero, G. Gigena, J. Gagliardi, A. Rodriguez, R. Sarmiento, S. Affatatto, M. Riccitelli, A. Petris, M. D. Datcu, C. Pop, M. Radoi, C. Arsenescu-Georgescu, I. Petrescu, L. Petrescu, L. Serban, E. Nechita, G. Tatu-Chitoiu, M. Dorobantu, I. Benedek, E. Craiu, C. Sinescu, D. D. Ionescu, C. Ginghina, B. Minescu, A. Izzo, P. Mantovani, L. Tomasi, L. Dall'oglio, S. Bonatti, R. Rosiello, M. Romano, F. Agostini, R. Zanini, Z. Y. Zhao, Y. J. Wu, J. J. Li, Y. J. Yany, H. Y. Qian, Y. D. Tang, A. T. Timoteo, A. Toste, A. Lousinha, R. Ramos, J. A. Oliveira, M. L. Ferreira, R. C. Ferreira, C. Cabades, J. L. Diez Gil, P. Aguar, D. Sanmiguel, A. Lopez-March, R. Marmol, L. Guerra, V. Girbes, J. Ferrando, A. Rincon De Arellano, L. Patricio, M. Blondal, T. Ainla, T. Marandi, J. Eha, M. M. Oliveira, M. N. Silva, P. S. Cunha, J. Feliciano, S. Silva, J. Kanovsky, P. Kala, J. Parenica, M. Poloczek, K. Prymusova, L. Kubkova, J. Spinar, D. Olinic, C. Homorodean, M. Ober, M. Olinic, C. Andrioaia, A. Condac, M. Masmoudi, B. Berdaoui, S. Labidi, C. Tapia Ballesteros, C. Hernandez Luis, M. G. Sandin, J. M. Vegas, R. Andion, N. Martinez, I. A. Gonzalez, M. Alvarado, I. J. Amat, J. A. San Roman, M. J. Garcia Gonzalez, E. Arroyo Ucar, C. Hernandez Garcia, M. Dorta Martin, F. Marrero Rodriguez, R. Dragu, M. Kapeliovich, H. Hammerman, D. Silva, N. Cortez-Dias, C. Jorge, J. Silva Marques, P. Carilho Ferreira, S. Robalo Martins, M. Almeida Ribeiro, C. Calisto, M. Fiuza, M. G. Lopes, P. Milicevic, M. Panic, I. Stankovic, D. Milicevic, T. Kalezic, S. Kafedzic, I. Ilic, M. Cerovic, B. Putnikovic, A. Neskovic, D. Rott, D. Leibowitz, Z. Monhart, J. Reissigova, H. Grunfeldova, P. Jansky, B. Valente, I. Villanueva Benito, I. Solla, E. Paredes, O. Diaz Castro, F. Calvo, J. A. Baz, A. Iniguez, A. Aleksova, R. Gerloni, R. Belfiore, C. Carriere, G. Barbati, E. Fabris, F. Possa, D. Nait, M. Milo, G. Sinagra, N. Marques, J. Mimoso, V. Gomes, R. M. Agra Bermejo, E. A. A. Emad Abu Assi, S. R. R. Sergio Raposeiras Roubin, P. C. G. Pilar Cabanas Grandio, C. P. G. Carlos Pena Gil, J. M. G. A. Jose Maria Garcia Acuna, J. R. G. J. Jose Ramon Gonzalez Juanatey, M. J. Daly, P. Scott, C. G. Owens, A. Tomlin, B. Smith, A. A. J. Adgey, L. R. Alvarez-Contreras, U. Juarez, A. Altamirano, A. Arias, A. Alvarez-San Gabriel, H. Gonzalez-Pacheco, C. Martinez-Sanchez, M. Rahnavardi, M. Keshtkar-Jahromi, H. Vakili, S. Gholamin, S. M. Razavi, T. Gilis-Januszewski, K.- P. Mellwig, M. Wiemer, J. Gilis-Januszewski, A. Peterschroeder, J. Koerfer, D. Horstkotte, M. Vrsalovic, B. Getaldic, N. Vrkic, H. Pintaric, S. Khan, B. Wasan, L. Moretti, P. Grossi, S. Silenzi, M. Testa, L. Candelori, L. N. Clementi, M. Forlini, L. Lando, M. L. Pezzuoli, P. Corradetti, G. Leurent, P. Y. Pennec, E. Filippi, B. Moquet, J. P. Hacot, P. Druelles, A. Rialan, G. Rouault, I. Coudert, H. Le Breton, S. Gevaert, F. Tromp, E. Vandecasteele, F. De Somer, Y. Van Belleghem, S. Bouchez, F. Martens, I. Herck, M. De Pauw, O. Ludka, M. Sepsi, R. Miklik, L. Dusek, D. Tomcikova, J. M. Garcia-Acuna, P. Aguiar-Souto, S. Raposeiras Roubin, R. Agra-Bermejo, M. Jacquet, E. Abu-Assi, J. R. Gonzalez-Juanatey, A. Ibatov, R. Labrova, R. Karlik, P. Lokaj, Q. She, S. B. Deng, S. H. Huang, L. J. Gu, J. I. A. N. Rong, Z. K. Wu, Y. Li, J. Zhang, L. Parascan, A. Campanile, L. Spinelli, G. Santulli, M. Ciccarelli, S. De Gennaro, E. Assante Di Panzillo, B. Trimarco, G. Iaccarino, E. Bobescu, G. Datcu, D. Dobreanu, B. Doka, J.- C. Charniot, C. Cosson, J. P. Albertini, R. Bittar, P. Giral, C. Cherfils, E. Guillerm, D. Bonnefont-Rousselot, A. Rusali, L. Cojocaru, I. Parepa, T. Koizumi, S. Iida, J. Sato, T. Kikutani, T. Muramatsu, S. Nishimura, N. Komiyama, W. P. Lee, B. B. Ong, K. Haralambos, D. Townsend, J. A. E. Rees, E. J. Williams, J. P. Halcox, I. Mcdowell, M. Damjanovic, G. Koracevic, D. Djordjevic-Radojkovic, M. Pavlovic, N. Krstic, S. Ciric-Zdravkovic, A. Stojkovic, Z. Perisic, S. Apostolovic, A. Faustino, L. Seca, S. Barra, F. Caetano, R. Providencia, J. Silva, P. Gomes, G. Costa, M. Costa, A. Leitao-Marques, A. L. Volkova, G. P. Arutyunov, N. A. Bylova, I. I. Dayter, Y. T. F. N. Jao, C. C. Fang, Y. Chen, C. L. Yu, S. P. Wang, J. Valencia, P. Perez-Berbel, J. M. Ruiz-Nodar, J. Pineda, P. Bordes, M. Quintanilla, V. Mainar, F. Sogorb, N. Santos, M. Serrao, H. Cafe, B. Silva, R. Oliveira, G. Caires, A. Drumond, J. Araujo, R. A. Providencia, P. L. Gomes, J. R. Pais, P. Mota, A. M. Leitao-Marques, S. Farhan, R. Jarai, I. Tentzeris, B. Vogel, M. K. Freynhofer, J. Wojta, K. Huber, M. Poli, P. Trambaiolo, F. Corsi, M. De Luca, M. Mustilli, V. Lukic, M. Simonetti, G. Ferraiuolo, M. Lettino, G. Casella, M. R. Conte, L. De Luca, G. Geraci, R. Ceravolo, A. Pani, G. Fradella, A. Schratter, H. Thiele, T. Klemm, K. Demmin, D. Lehmann, M. Mende, G. Schuler, U. Pittl, A. Chernova, S. U. Nikulina, T. Naruke, T. Inomata, T. Yanagisawa, E. Maekawa, T. Mizutani, H. Shinagawa, M. Nishii, I. Takeuchi, H. Takehana, T. Izumi, C. Paulo, J. Mascarenhas, M. Patacho, J. Pimenta, P. Bettencourt, S. Nardai, G. Y. Szabo, B. Berta, I. Edes, B. Merkely, J. Delgado Silva, R. Baptista, R. Faria, J. Trigo, P. Gago, G. Gheorghe, I. T. Nanea, A. Cristea, S. Almarichi, H. Martins, F. Saraiva, E. Jorge, P. L. Mendes, P. Monteiro, S. Costa, F. Franco, L. A. Providencia, T. Nanea, G. S. Gheorghe, S. Visan, N. Paun, R. Gaber, R. Delewi, R. Nijveldt, H. A. De Bruin, A. Hirsch, A. Van Der Laan, B. J. Bouma, J. P. G. Tijssen, A. C. Van Rossum, F. Zijlstra, J. J. Piek, H. Rus, M. Donea, C. Ciurea, G. Ifteni, G. Casolo, M. Chioccioli, M. Magnacca, J. Del Meglio, A. Comella, M. Baratto, J. Lera, L. Salvadori, C. Tessa, C. Vignali, Z. Keca, T. Momcilov Popin, G. Panic, R. White, F. Mateen, A. Weaver, Y. Agmon, E. Okisheva, D. Tsaregorodtsev, V. Sulimov, I. J. Amat Santos, C. Hernandez, C. Tapia, A. Campo, D. Fredman, L. Svensson, M. Rosenqvist, S. Tadel-Kocjancic, P. Radsel, R. Knafelj, V. Gorjup, M. Noc, E. Zima, Z. S. Jenei, E. Kovacs, I. Osztheimer, L. Molnar, A. Horvath, D. Becker, L. Geller, R. Maggi, T. Furukawa, V. Viscardi, M. Brignole, S. R. N. Leal, H. Dores, I. Rosario, J. Monge, M. J. Carvalho, I. Arroja, A. Leitao, C. Fonseca, A. Aleixo, A. Silva, S. Keuleers, P. Herijgers, M. C. Herregods, W. Budts, C. Dubois, B. Meuris, P. Verhamme, W. Flameng, F. Van De Werf, T. Adriaenssens, H. Badran, M. Elnoamany, T. Lolah, C. Olariu, C. Macarie, M. A. H. Mollik, A. I. Hassan, T. K. Paul, M. Z. Haque, R. Jahan, M. Rahmatullah, M. A. Khatun, M. T. Rahman, M. H. Chowdhury, J. Bustamante Munguira, E. Tamayo, I. Garcia-Cuenca, E. Bustamante, J. Gualis, M. L. Gomez-Martinez, S. Florez, J. I. Gomez-Herreras, R. Ramirez Rodriguez, A. M. Ramirez Rodriguez, M. A. Garcia-Bello, E. Hernadez Ortega, E. Caballero Dorta, A. Garcia Quintana, V. Piro Mastraccio, A. Medina Fernandez Aceytuno, E. Assanelli, M. De Metrio, M. Rubino, G. Lauri, A. Cabiati, J. Campodonico, M. Grazi, M. Moltrasio, I. Marana, G. Marenzi, M. Lovlien, B. Schei, R. Picon-Heras, C. Acebal, J. C. Garcia Rubira, D. Vivas Balcones, I. Nunez-Gil, B. Ruiz-Mateos, B. Ibanez, A. Fernandez-Ortiz, V. D. Vintila, O. A. Enescu, C. I. Stoicescu, C. Udroiu, M. Cinteza, G. Tatu - Chitoiu, D. Vinereanu, C. Fresco, M. De Biasio, D. Muser, R. Sappa, G. Morocutti, G. Bernardi, A. Proclemer, B. Fontanella, A. Affatato, C. Ciccarese, M. Sacchini, M. Volpini, F. Bianchetti, G. Verzura, L. Dei Cas, R. Pudil, V. Blaha, J. Vojacek, I. Paraskevaidis, I. Ikonomidis, J. Parissis, C. Papadopoulos, V. Stasinos, V. Bistola, M. Anastasiou-Nana, M. Shochat, A. Shotan, M. Kazatsker, V. Gurovich, A. Asif, E. Noiman, Y. Levy, D. Blondhaim, P. Rabinovich, S. Meisel, S. Petrovic, J. Glasnovic, M. Tomasevic, D. Sakac, S. Obradovic, O. Londono Sanchez, S. Pacreu, L. Torres, G. Mihaylov, G. M. Shaban, E. Trendafilova, V. Krasteva, T. S. Mudrov, J. P. Didon, V. Panageas, N. Vlachos, A. Pernat, I. Radan, H. Mozina, P. Pepi, F. Cionini, N. Baccaglioni, A. Viertel, J. Havers, G. Ballard, G. Groenefeld, L. M. Branco, L. Ferreira, A. Fiarresga, L. Lettieri, A. Reggiani, R. Juarez Prera, G. Blanco Palacios, A.- C. Martin, S. Manzo Silberman, A. Chaib, O. Varenne, P. Allouch, E. Salengro, A. Jegou, O. Margot, C. Spaulding, A. Diego, A. De Miguel, C. Cuellas, E. Fraile, J. Martin, B. Vega, R. Bangueses, F. Fernandez-Vazquez, A. Perez De Prado, S. Leal, M. J. Correia, J. C. Monge, J. Abecasis, C. Garcia-Garcia, I. Subirana, J. Sala, J. Bruguera, V. Valle, G. Sanz, M. Fiol, F. Aros, J. Marrugat, R. Elosua, S. N. C. Barra, A. Leitao Marques, Y. J. Yang, B. Xu, G. Y. Song, R. L. G, A. Aleksic, P. Serpytis, K. Rucinskas, A. Kalinauskas, N. Karvelyte, C. I. Santos De Sousa, S. Ferreira, J. Calaca, N. Lousada, R. Palma Reis, D. M. Gualandro, L. F. B. C. Seguro, F. G. M. Braga, O. M. Silvestre, R. L. Lage, J. Fabri, M. T. Oliveira, J. A. Urbano Moral, J. Torres Llergo, R. Solanilla Rodriguez, A. Sanchez Gonzalez, A. Martinez Martinez, C. A. Den Uil, W. K. Lagrand, M. Van Der Ent, L. S. D. Jewbali, J. M. Cheng, P. E. Spronk, M. L. Simoons, C. Mornos, D. Dragulescu, A. Ionac, J. Guardado, O. Azevedo, M. Fernandes, F. Canario-Almeida, V. Sanfins, A. Pereira, J. Almeida, V. U. Kaplunova, Y. N. Belenkov, E. V. Privalova, A. A. Fomin, A. Y. Suvorov, A. Goodkova, M. G. Rubakova, I. A. Kuznetsova, E. N. Semernin, F. Keshavarzi, J. Kojuri, V. M. Mikhailov, I. V. Vezhenkova, A. Y. A. Goodkova, I. Pavlovic, M. Schwarz, G. Jakl, P. Smetana, T. Perkmann, A. Mayr, J. Mair, G. Klug, M. Schocke, T. Trieb, W. Jaschke, O. Pachinger, B. Metzler, L. Bronze Carvalho, J. Azevedo, M. L. Andrade, M. J. Relvas, J. Coucello, G. Morais, M. Seabra, F. Afamefule, M. Luaces Mendez, R. Teijeiro-Mestre, I. J. Nunez-Gil, N. Leco-Gil, E. Madronal-Cerezo, I. Zannin, J. Ruiz, M. A. Orynchak, I. I. Vakalyuk, I. P. Vakalyuk, A. Berezin, T. Panasenko, Y. Cavusoglu, A. Cavusoglu, I. Unluoglu, M. Tek, C. Demirustu, B. Gorenek, M. Unalacak, A. Birdane, F. Yuksel, N. Ata, J. P. J. Halcox, A. Beyaztas, E. Entok, I. Uslu, A. Schaefer, U. Flierl, N. Seydelmann, J. Bauersachs, L. Calmac, S. Marinescu, G. Tatu Chitoiu, A. G. Fruntelata, S. Hamdi, Y. Maazoun, A. Neji, O. Farhat, M. Majdoub, K. Ben Hamda, F. Maatouk, S. M. Balanescu, I. Nedelciuc, D. Deleanu, F. Ortan, S. Mot, P. R. Sinnaeve, S. Moreels, M. Coosemans, T. Vydt, W. Desmet, D. Tobing, R. Rifnaldi, D. Juzar, I. Firdaus, S. Dharma, I. Irmalita, H. Kalim, R. Bejiqi, R. Retkoceri, H. Bejiqi, L. Kryeziu, M. Kelmendi, S. H. Borovci, S. M. Victor, A. Gnanaraj, R. Deshmukh, A. S. Mullasari, M. Yahalom, R. S. Kaiyal, N. Roguin, J. Bornstein, S. Atar, R. Farah, L. F. Seca, A. M. Leitao Marques, R. Margato, P. Sousa, H. Ribeiro, L. Rocha, A. Correia, J. I. Moreira, H. C. Carvalho, M. Afifi, N. Abed, A. Suarez-Barrientos, D. Vivas, F. Castro-Ferreira, E. Franco, J. C. Garcia-Rubira, V. Fuster, C. Macaya, B. Ibanez Cabeza, S. Salinger, D. Milic, T. Stanojlovic, T. Kostic, M. A. Khan, F. Vrapi, K. Naeem, J. Davar, K. Hristova, G. Pencheva, R. Radeva, S. Milanov, A. Fareed, M. Oraby, G. M. Nasr, F. Maklady, P. Dupouy, J. T. Sorensen, C. J. Terkelsen, J. F. Lassen, S. Trautner, E. F. Christensen, T. T. Nielsen, H. E. Botker, H. R. Andersen, K. A. Thygesen, L. Checco, T. Usmiani, P. L. Sbarra, M. Boffini, R. Saviolo, C. Grasso, F. Conrotto, M. Marchetti, M. Rinaldi, S. Marra, F. Moscoso Costa, J. Ferreira, L. Raposo, C. Aguiar, M. Trabulo, J. A. Silva, V. Marques, A. Swiatkowski, J. Kowalczyk, R. Lenarczyk, P. Chodor, G. Honisz, T. Was, M. Swierad, B. Sredniawa, L. Polonski, Z. Kalarus, A. S. Postadzhiyan, H. Velinov, V. Velchev, D. Hazarbasanov, M. Apostolova, B. 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Salazar Mendiguchia Y Garcia, J. A. Gomez Hospital, J. Maristany Daunert, F. J. Berdejo Gago, E. Esplugas Oliveras, A. Brzozowska-Czarnek, A. Urbanik, N. Kakouros, S. Kakouros, J. Lekakis, J. Rizos, D. Kokkinos, J. Venevtseva, A. Melnikov, M. Valiahmetov, T. Gomova, I. Perelomova, J. J. Ferrer Hita, F. Bosa-Ojeda, A. Sanchez-Grande-Flecha, G. Yanes-Bowden, M. J. Vargas-Torres, A. Rodriguez-Gonzalez, C. Rubio-Iglesias-Garcia, A. Dominguez-Rodriguez, C. Enjuanes-Grau, F. Marrero-Rodriguez, A. I. Suceveanu, A. Suceveanu, L. Mazilu, L. Alexandrescu, E. Dumitru, V. Miu, V. Jitari, F. L. Voinea, K. P. Balachandran, R. Schofield, R. Sankaranarayanan, K. Helm, C. Crowe, R. Singh, J. Mcdonald, M. J. Chuen, M. Kobusiak-Prokopowicz, M. Preglowska, A. Mysiak, T. Doi, T. Sakoda, T. Akagami, T. Naka, T. Tsujino, T. Masuyama, M. Ohyanagi, N. Kume, H. Mitsuoka, K. Hayashida, M. Tanaka, L. M. Biasucci, R. Della Bona, G. Biasillo, M. Leo, M. Zaninotto, M. Plebani, F. Crea, R. Dellabona, B. Gok, A. Unalir, B. Timuralp, N. Nikulina, S. S. Yakushin, G. I. Furmenko, S. A. Akinina, R. Ingrid, L. Bronze, S. Djambazov, A. Zhivkov, I. Maznev, M. Ingeliev, R. Slavov, N. Cvetkova, V. Patarinski, L. Groch, J. Horak, N. Dimitrov, H. G. Hayrapetyan, P. Cabanas-Grandio, C. Pena-Gil, N. A. Mc Keag, C. J. Mc Cann, C. Cardwell, I. S. Young, N. Mikhalchikova, N. Burova, M. Zaccaria, P. Palmisano, V. Palumbo, M. M. Ciccone, S. Favale, K. C. Chen, W. H. Yin, J. H. Liu, S. Goncalves, J. F. Santos, P. Amador, L. N. Soares, K. Zahidova, F. Guliyev, N. Zahidov, P. Carrilho-Ferreira, J. S. Marques, J. Carvalho De Sousa, H. Uthoff, C. Thalhammer, M. Potocki, T. Reichlin, M. Noveanu, M. Aschwanden, D. Staub, N. Arenja, T. Socrates, C. Mueller, Y. Zhao, X. Wu, Q. Xue, L. Gao, H. Lin, S. Wang, K. Watanabe, A. Kawamura, T. Seko, A. Omura, S. Sakabe, A. Kasai, A. V. Starodubova, G. Storozhakov, O. Kisliak, F. Hautieva, M. Tursheva, N. Fedotova, R. C. Di Maio, J. Mclaughlin, J. D. Allen, J. M. C. Anderson, H. Khaled Nagi, O. Tayeh, W. Farok, A. Mousa, P. Neuzil, J. Skoda, J. Petru, L. Sediva, S. Kralovec, F. Holy, K. Holdova, P. Jehlicka, P. Plasil, V. Y. Reddy, S. Alabakovska, D. Labudovic, S. Jovanova, K. Tosheska, M. Alabakovski, K. Jeevaratnam, S. P. Tee, Y. Zhang, L. Guzadhur, I. S. Gurung, R. Duehmke, A. A. Grace, M. Lei, C. L. Huang, Y. Ishibashi, M. Yamauchi, Y. Akashi, H. Musha, F. Miyake, T. Hnatek, L. Kamenik, P. Sedlon, J. Luxova, B. Steuerova, J. Skvaril, M. Cernohous, M. Zavoral, N. Ratkovic, N. R. Nemanja Djenic, A. J. Aleksandra Jovelic, S. O. Slobodan Obradovic, B. G. Branko Gligic, E. Kletsiou, M. Giannakopoulou, E. Bozas, E. K. Iliodromitis, E. D. E. Papathanassoglou, M. Anton, G. Anton, M. Muraru, S. Salinger Martinovic, M. Radosavljevic, D. Stanojevic, M. Zivkovic, T. Pessoa, N. Aspromonte, C. Ronco, M. Tubaro, M. Santini, F. Colivicchi, A. Aiello, D. Cruz, A. Anzoletti Boscolo, G. Vianello, R. Valle, A. Parspour, S. Watkins, D. Datta, A. G. Nikishin, M. M. Pirnazarov, T. A. Nurbaev, Z. Motovska, M. Fischerova, P. Osmancik, M. Maly, P. Widimsky, E. Pavli, A. Dibra, J. Mehilli, L. Dibra, A. Schoemig, A. Kastrati, P. Carmo, M. Almeida, R. Teles, P. Goncalves, J. Brito, F. D'ascenzo, A. Gonella, G. Longo, A. Pullara, C. Moretti, F. Sciuto, P. Omede', G. Biondi Zoccai, G. P. Trevi, I. Sheiban, H. M. Cafe, D. Pereira, D. Freitas, D. Ortiz Berbel, J. M. Rabasa Baraibar, A. M. Leone, A. De Caterina, A. Aurelio, A. Sciahbasi, E. Lioy, C. Trani, F. Burzotta, I. Porto, A. G. Rebuzzi, K. Trusinskis, D. Juhnevica, K. Strenge, D. Sondore, I. Kumsars, S. Jegere, I. Narbute, A. Grave, I. Zakke, A. Erglis, C. Ferrari, A. L. Bartorelli, M. Saeed, D. Cozma, S. Pescariu, S. I. Dragulescu, H. S. Kamal, A. Abdelfattah, A. M. Abdelbary, H. Elassar, A. Naggar, M. Khaled, A. M. Fareed, J. M. Pernes, J. C. Gaux, M. W. Prull, B. Sasko, H. Wirdemann, A. Bittlinsky, T. Butz, H. J. Trappe, M. Perazzolo Marra, L. Cacciavillani, A. Marzari, M. De Lazzari, R. Turri, P. China, F. Corbetti, S. Iliceto, L. L. Stazhadze, E. A. Spiridonova, N. A. Bulanova, A. A. Ermolaev, L. Savic, I. Mrdovic, G. Krljanac, J. Perunicic, M. Asanin, R. Lasica, M. Matic, Z. Vasiljevic, M. Ostojic, M. Tichy, C. Andrys, A. Conti, C. Poggioni, G. Viviani, F. Bulletti, V. Boni, M. Luzzi, S. Vicidomini, M. Donati, B. Del Taglia, R. Pini, O. Sousa, R. Fontes-Carvalho, D. Caeiro, N. Dias Ferreira, G. Silva, E. Pereira, J. Ribeiro, A. Albuquerque, V. Gama Ribeiro, M. Murai, Y. Takeda, T. Shinmyo, J. Tanigawa, H. Hazui, T. Nakakohji, Y. Ohishi, M. Hoshiga, T. Ishihara, T. Hanafusa, J. Belohlavek, V. Rohn, J. Kunstyr, M. Lips, M. Semrad, F. Mlejnsky, J. Tosovsky, A. Linhart, J. Lindner, Z. Sablik, A. Samborska-Sablik, J. Drozdz, W. Gaszynski, M. M. Izquierdo-Gomez, R. Juarez-Prera, G. Blanco-Palacios, R. Lakhdar, M. Drissa, B. Jedaida, H. Drissa, F. Sampaio, H.- T. Hsin, J.- H. Huang, K.- M. Chiu, Z.- S. Chen, P.- C. Lin, L.- Y. Chen, S.- H. Chu, I. Efthimiadis, P. Skendros, A. Sarantopoulos, P. Boura, A. M. Van Der Laan, P. A. Van Der Vleuten, M. Klees, J. G. P. Tijssen, B. E. Backus, A. J. Six, J. H. Kelder, A. Mosterd, E. G. Mast, T. P. Mast, R. Braam, R. Tio, R. Veldkamp, P. A. Doevendans, N. Paarup Dridi, L. Holmvang, T. Engstroem, S. Rekik, J. Brunet, F. X. Hager, G. Bayet, L. Meille, J. M. Quatre, J. Sainsous, P.- H. Chu, C.- H. Tang, N. Pogosova, I. E. Koltunov, I. D. Sapunova, V. A. Vigodin, R. Uhliar, A. Schmidt, B. Brockmeyer, A. Suzuki, Y. Eki, H. Higuchi, A. Yukawa, R. Yamauchi, Y. Sato, Y. Endo, J. Salazar Mendigucha Garcia, S. Homs Vila, A. Cequier Fillat, R. Andion Ogando, M. Sandin Fuentes, J. M. Vegas Valle, I. A. Gonzalez Garcia, I. A. Duro Aguado, A. J. Palomino Doza, I. Gomez Salvador, J. A. San Roman Calvar, T. M. Mamarasulov, L. Todorovic, Z. C. H. Cherneva, S. D. Denchev, K. Heltai, A. Boytsov, N. N. Nikulina, D. Zanna, V. Marangelli, C. Caiati, R. Picon Heras, M. J. Loureiro, I. Urazovskaya, D. Vinogradova, E. Vasilieva, A. Shpektor, E. Conti, M. B. Musumeci, F. M. Lauri, E. Dito, M. De Giusti, A. Lallo, D. Fusco, M. Davoli, M. Volpe, C. Autore, H. Gamra, Z. Dridi, M. Hassine, F. Addad, I. Gherissi, A. Reda, M. Mahjoub, S. Bouraoui, M. Abdennadher, F. Betbout, P. M. F. P. Mota, J. D. Silva, R. Jankovic Tomasevic, V. Djordjevic, D. Djordjevic Radojkovic, A. Scafa Udriste, A. Fruntelata, E. Gainoiu, S. Bogdan, D. Zamfir, C. Teodorescu, M. Guran, D. Constantinescu, A. Konopka, M. Banaszewski, I. Wojtkowska, J. Stepinska, J. V. Vidergold, I. V. Osipova, T. V. Tavrovskaya, J. V. Galkina, A. V. Timofeev, R. I. Vorobyov, E. N. Vorobyova, L. Matos, A. C. C. Carvalho, W. Oliveira, F. Cintra, D. Poyares, M. Andersen, R. Martins, S. Tufik, P. Ostadal, J. Brada, S. Horakova, M. Mlcek, V. Hrachovina, O. Kittnar, I. V. Gorudko, I. V. Buko, S. N. Cherenkevich, L. Z. Polonetsky, V. Y. Plotkin, M. A. Timoshina, S. V. Azanchevskaya, N. N. Chromov-Borisov, A. Vorlat, L. Snoep, M. J. Claeys, C. J. Vrints, A. Palazzuoli, M. Caputo, I. Quatrini, A. Calabro, G. Antonelli, M. S. Campagna, B. Franci, R. Nuti, A. Maisel, M. Negrini, T. Minora, P. Marino, R. Seregni, E. Tavlueva, O. Barbarash, L. Barbarash, T. Janota, J. Kudlicka, K. Malik, D. Wichterle, J. Hradec, R. Body, S. D. Carley, G. Mcdowell, M. Nuttall, C. Wibberley, M. France, J. K. Cruickshank, K. Mackway-Jones, M. Leon, C. Cozma, F. Mitu, D. R. Almeida, C. B. Dias, I. Burazor, M. Burazor, M. Krstic, M. Lazovic, M. Vukmanovic, J. Djordjevic, Z. Radovanovic, D. Ilic, P. Bosnjakovic, A. C. Ferreira, P. S. Mateus, P. Fontes, T. Teixeira, G. Conte, A. Menozzi, E. Solinas, M. G. Bolognesi, I. Tadonio, F. Mantovani, A. Cattabiani, L. Vignali, D. Ardissino, O. Tautu, A. Alexandrescu, R. Niculescu, R. Jankovic, N. Bozinovic, C. Santos, F. Costa, G. Cardoso, I. Correia, K. Fountoulaki, S. Kastellanos, E. Voltirakis, A. Kokotos, C. Michalakeas, K. Kontsas, K. Hasioti, E. T. Iliodromitis, M. G. Sandin Fuentes, E. Zatarain Nicolas, N. Martinez Uruena, M. Alvarado Montes De Oca, V. Dytrych, T. Kovarnik, O. Smid, A. Kral, A. G. Aroutunov, S. Intwala, I. Jegere, H. S. H. Shaalan, Z. Pagava, R. Agladze, R. Shakarishvili, N. Sharashidze, L. Gujejiani, G. Saatashvili, T. Z. Katova, V. Kostova, Y. Simova, S. Vukotic, S. Rafajlovski, R. Romanovic, N. Antonijevic, B. Gligic, M. Hutyra, T. Skala, D. Horak, D. Vindis, M. Taborsky, A. Contine, M. Del Pinto, F. Angeli, P. Verdecchia, F. Borgognoni, E. Grikstaite, P. Pantano, G. Ambrosio, C. Cavallini, C. Bonanad, J. Sanchis, V. Bodi, J. Nunez, X. Bosch, M. Heras, M. Pellicer, A. Llacer, L. Adao, M. Oliveira, H. Goncalves, J. Primo, V. Gama, C. Lombardi, M. Metra, S. Bugatti, E. Pasotti, F. Quinzani, M. Adamo, C. Villa, R. Rovetta, A. Manerba, M. Mariani, A. Dushpanova, M. Baroni, E. Cerone, A. Nardelli, J. Gianetti, S. Berti, F. Feliciano, R. Soares, S. Santos, A. Kruger, D. Vondrakova, J. Herget, C. Navarro, N. A. Cromie, J. A. A. Adgey, D. Caeiro Pereira, P. Braga, R. Fontes Carvalho, A. Rodrigues, M. Goncalves, L. Simoes, and K. V. Borisov

Subjects
Cardiology and Cardiovascular Medicine
Published
2010
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7. China's Economic Development

Author

Dennis Yang, J. Brada, P. Wachtel, Dennis Yang, J. Brada, and P. Wachtel

Subjects
Economic development--China
Abstract

This collection of papers is from Palgrave's journal Comparative Economic Studies, carefully selected by a team of expert editors, this volumes collates the most sophisticated works to provide the readers with an essential guide to the economic development of China.

Published
2014

8. [A comparison of two methods of long-term external ECG telemonitoring in patients after ablation for atrial fibrillation]

Author

J, Chovančík, V, Bulková, M, Fiala, J, Gandalovičová, S, Královec, R, Neuwirth, H, Tolaszová, O, Jiravský, J, Brada, and J, Januška

Subjects
Adult, Male, Recurrence, Atrial Fibrillation, Catheter Ablation, Electrocardiography, Ambulatory, Humans, Telemetry, Female, Middle Aged, Aged
Abstract

The aim of the study was to compare two methods of long-term ECG monitoring after atrial fibrillation (AF) ablation.The study included 279 patients with paroxysmal (n = 163) or persistent (n = 116) AF, who were followed up for 1 year after the first catheter ablation for AF. All patients were provided with episodic ECG recorder for 1 year and instructed to send at least 2 random ECG recordings per day and whenever they sensed symptoms. They were also provided with external loop recorder for 2-3 weeks at 6 and 12 months to enable more continuous ECG monitoring.At the end of 39 ± 12 (12-60) month follow-up, 143 (88%) patients with paroxysmal AF, and 105 (91%) patients with persistent AF, respectively, remained in stable sinus rhythm. The efficacy of episodic recorder expressed as a ratio of patients with identified AF/atrial tachycardia (AT) out of all patients with a documented episode of AF/AT was superior to the efficacy of loop recorder. No AF/AT episode was recorded with the loop recorder that was not also documented by the episodic recorder. Of the patients with the AF/AT recurrence detected by the episodic recorder, the arrhythmia was also revealed by the loop recorder in 70% of the patients after paroxysmal AF ablation (p0.001), and in 52% of the patients after persistent AF ablation (p = 0.006). Asymptomatic AF/AT was present in 42 (26%) of patients with paroxysmal AF, and in 28 (24%) patients with persistent AF (p = 0.810). From conventional follow-up unexpected and clinically significant episode of AF/AT that required change in therapy was detected in 9 (5.5%) patients after ablation for paroxysmal AF, and in 4 (3.4%) patients after ablation for persistent FS.More episodes of AF/AT after ablation were detected by 1-year daily ECG monitoring using episodic recorder as compared to periodic ECG monitoring with loop recorder. Identification of clinically significant episodes of AF/AT unrecognized from conventional follow-up was low.

Published
2012

9. Section 5 -in vitro cultures

Author

E. Abbas, V. Borkovec, V. Snášelová, S. Procházka, I. Blanárik, I. Partlová, P. Blanarik, M. Bobák, K. Erdelský, M. Nádaská, J. Šamaj, J. Krištín, R. Brutovská, E. Čellárová, Z. Bugárová, A. Preäová, I. Burdová, J. Opatrná, E. čellárová, K. Kimáková, R. Brutovska, B. Dedičová, K. J. Puite, J. H. N. Schel, A. C. J. Timmers, J. Dubová, L. Zacharníková, Š Sýkorová, L. Havel, D. J. Durzan, J. Procházka, J. Horák, K. Rozsypalová, A. Fojtík, M HrubcovÁ, N. ČeŘovskÁ, J. Hřib, J. Jásik, A. Lux, Z. Ježek, H. Vlašínová, V. Kollár, H. Korčáková, A. KormuŤák, B. Vooková, A. Gajdošová, J. Kováč, M. Lhotová, G. Libiaková, H. Lipavská, J. Brada, L. Nátr, M. Vlachová, Z. Opatrný, M. G. Ostrolucká, R. Pospíšilová, T. Macek, T. Vaněk, N. C. A. Ruijter, A. A. M. Lammeren, T. Salajova, J. Salaj, A. Kormuťák, V. Skládal, M. Vyvadilová, J. Láchova, Z. Sladký, M. Klemš, J. Blažková, J. Solárová, D. Součková, J. Ullmann, Z. Vondráková, J. Svojšová, A. Okolot, Yu. Gleba, M. Truksa, H. Konečná, J. Pospíšilová, M. Vagner, I. Macháčková, B. Vančová, D. Žemlová, and A. Novacký

Subjects
0106 biological sciences, 0303 health sciences, 03 medical and health sciences, Section (archaeology), Geotechnical engineering, Plant Science, Horticulture, Biology, 01 natural sciences, 030304 developmental biology, 010606 plant biology & botany
Published
1992
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10. Magnetic resonance imaging of the rat brain after epileptic seizures--preliminary results

Author

M Z, Kuchar, P, Jerábková, J, Brada, J, Kaspar, J, Skrivan, J, Betka, and M, Langmeier

Subjects
Diffusion Magnetic Resonance Imaging, Epilepsy, Kainic Acid, Animals, Brain, Rats, Wistar, Rats
Abstract

The magnetic resonance imaging (MRI) of the rat brain after the epilepsy seizures has been performed. As a first step, the model of the kainic acid (KA) induced seizures has been conducted to examine the possibilities of magnetic resonance imaging system kept in disposition. Seven Wistar albino rats, weighing about 300 g, were used in this study. We administered six of them with intraperitoneal injection of 10 mg/kg of KA. The control animal received corresponding volume of the saline. Every animal was examined under systemic anaesthesia induced by an intraperitoneal injection of thiopental sodium approximately 15 minutes before scanning. Diffusion-weighted imaging (DWI) has been used to acquire the coronary scans of the rat brain. The progress of hyper intense signal at the cerebral cortex and amygdale has been observed. Marked asymmetry of the signal intensity between hemispheres has been discovered. Subsequently the experimental model of audiogenic epilepsy will be conducted.

Published
2006

11. P70 Esophageal temperature measurement during balloon cryoablation for paroxysmal atrial fibrillation

Author

J. Brada, K. Kemzova, K. Holdova, P. Neuzil, Jan Skoda, J. Baroch, L. Plevkova, D. Flidrova, K.B. Bari, and J. Petra

Subjects
Advanced and Specialized Nursing, medicine.medical_specialty, business.industry, Paroxysmal atrial fibrillation, medicine.medical_treatment, P wave, Cryoablation, Balloon, Medical–Surgical Nursing, Esophageal temperature measurement, Internal medicine, medicine, Cardiology, Cardiology and Cardiovascular Medicine, business
Published
2011
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13. Post-insertion care of patients with removable dentures

Author

W L, Harvey and B J, Brada

Subjects
Postoperative Care, Self Care, Denture, Complete, Patient Education as Topic, Aftercare, Denture, Complete, Immediate, Denture, Partial, Removable, Humans, Denture Cleansers, Oral Hygiene
Published
1993

14. 80 Poster 3D High Speed Rotation Angiography using System Dyna-CT for Catheter Ablation of Atrial Fibrillation and Atrial Tachycardia

Author

S.K. Kralovec, Jan Skoda, F.H. Holy, Jan Petru, P. Neuzil, J. Brada, and L. Plevkova

Subjects
Advanced and Specialized Nursing, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, P wave, Atrial fibrillation, Catheter ablation, medicine.disease, Rotation, Medical–Surgical Nursing, Internal medicine, Angiography, medicine, Cardiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Atrial tachycardia
Published
2010
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15. 157 Poster Electroanatomical Mapping for Navigation of VT Surgery

Author

K.B. Bari, F.H. Holy, Jan Petru, J. Brada, S.K. Kralovec, P. Neuzil, K.S. Smolikova, and Jan Skoda

Subjects
Advanced and Specialized Nursing, Medical–Surgical Nursing, Electroanatomic mapping, medicine.medical_specialty, business.industry, Medicine, Radiology, Cardiology and Cardiovascular Medicine, business
Published
2010
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16. An update of a one-appointment master impression and jaw relation record technique

Author

W L, Harvey and B J, Brada

Subjects
Denture Bases, Dental Impression Technique, Jaw Relation Record, Office Visits, Dental Impression Materials, Humans
Abstract

Dentists may want to consider using an update of a unique complete denture technique that saves total chair time and, therefore, decreases cost. The technique combines appointments two and three, during which time the dentist both makes the master impressions and records the maxillomandibular relationships. In the past, protection of the maxillomandibular relationship records during the subsequent laboratory work was a problem. By applying new, tough, and thin denture base materials to the technique, the dentist will be less likely to distort the maxillomandibular records while boxing and pouring the impressions.

Published
1992

17. Poster Session 1: Atrial fibrillation clinical aspects

Author

R. A. Providencia, M. Shaheen, J. Gajek, A. M. Leita-Marques, M. Senga, M. Leustean, D. K. Kocinaj, J. Silva, S. Havranek, L. Stoica, V. Indries, F. Fernandez-Aviles, K. Sonne, S. Pescariu, A. Matsuo, A. Arenal, B. Coll-Vinent, N. Quintal, L. Armanijian, E. Soliman, J. Almendral, F. Atienza, M. Chudzik, D. Zysko, O. Ozcan Celebi, T. Kawamiya, A. Alonso, M. Morar, L. Petrescu, P. L. Gomes, M. D. Smit, F. R. Bolohan, J. Chovancik, U. Ravens, R. Alexandru, A. C. P. Wiesfeld, T. Datino, T. Meinertz, V. Kanic, L. G. Tunyan, S. Tanaka, K. Ivanova, M. Ito, D. Vokac, K. G. Haeusler, G. Heiss, S. Sugiura, S. Aydogdu, G. Cristian, M. Gashi, D. Suran, S. Celebi, M. Nakamura, K. Yokoi, T. Murohara, D. Calvo, A. Montroig, E. Gonzalez-Torrecilla, B. Fornes, E. Fujii, S. Yamazato, L. F. Atea, V. Bulkova, D. Patel, W. Mazurek, L. Benito, A. Canbay, S. Granda, A. Klimczak, T. Hibino, F. Golda, D. C. Cozma, D. Wichterle, J. K. Wranicz, M. Oeff, G. Fluxa, J. D. Burkhardt, S. Agarwal, I. C. Van Gelder, S.-M. Bailey, E. P. Pllana, D. Sahin, D.J. Van Veldhuisen, A. V. Ranchor, I. Cygankiewicz, G. Breithardt, U. Tebbe, P. Venkatraman, D. D. Ionescu, A. Botelho, W. Kucharski, S. Ahmed, M. Kitamura, K. Kato, G. Steinbeck, M. Rienstra, S. V. Grigoryan, S. I. Dragulescu, J. Brada, C. Luca, R. Simpson, V. Nedog, N. Makita, J. D. Lefrandt, L. Mont, H. Fujita, J. Simek, M. Fiala, K. Yajima, F. Naji, K. Inoue, A. Chamberlain, M. Sabovic, C. Sprenger, K. Matsuo, Y. Shiono, M. Mihai, E. Diker, T. Fujimaki, L. Seca, J. Hoyo, A. Natale, K. Dohi, A. Oszczygiel, and M. Ambrose

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Internal medicine, medicine, Cardiology, Atrial fibrillation, Session (computer science), Cardiology and Cardiovascular Medicine, medicine.disease, business
Published
2009
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18. Poster session 3: Miscellaneous

Author

T. Potpara, M. Grujic, M. Ostojic, B. Vujisic, M. Polovina, N. Mujovic, E. Hatzinikolaou-Kotsakou, E. Reppas, T. H. Beleveslis, G. Moschos, M. Kotsakou, K. Tsakiridis, E. Simeonidou, A. Papandreou, G. Tsigas, C. Michalakeas, C. Tsitlakidis, D. Alexopoulos, J. Lekakis, D. T. Kremastinos, D. Poci, L. Backmn, T. H. Karlsson, N. Edvardsson, P.- G. Golzio, M. Vinci, C. Amellone, M. Jorfida, V. Veglio, E. Gaido, G. P. Trevi, M. G. Bongiorni, L. Ding, W. E. I. Hua, S. H. U. Zhang, K. E. P. I. N. G. Chen, F. Z. Wang, X. I. N. Chen, B. Dokumaci, A. S. Dokumaci, S. Ozyildirim, M. Yolcu, C. Uyan, S. Nicolas-Franco, J. Rodriguez Gonzalez, C. Albacete-Moreno, G. Ruiz-Villa, A. Sanchez-Martos, D. Bixquert-Genoves, P. Skoczynski, J. Gajek, D. Zysko, M. Porebska, K. Josiak, W. Mazurek, R. A. Providencia, J. Silva, L. Seca, P. L. Gomes, S. Barra, P. Mota, J. Nascimento, A. M. Leitao-Marques, Y. Kikuchi, P. A. Brady, P. Erne, J. Val-Mejias, J. Schwab, R. Schimpf, M. Orlov, T. Mattioni, J. Amlie, F. Sacher, B. Lahitton, J. Laborderie, M. Wright, M. Haissaguerre, T. Berger, R. Zwick, W. Dichtl, M. Stuehlinger, O. Pachinger, F. Hintringer, K. Toli, K. Koutras, J. Stauropoulos, S. Vichos, J. Mantas, C. R. Rodriguez Artuza, J. A. Hidalgo L, A. Garcia, P. Fumero, A. Perez, I. Rangel, S. Perl, P. Stiegler, A. Kollmann, B. Rotman, P. Lercher, M. Anelli-Monti, K. H. Tscheliessnigg, B. M. Pieske, K. Nakamura, S. Naito, K. Kumagai, K. Goto, J. Iwamoto, N. Funabashi, S. Oshima, I. Komuro, J. Stavropoulos, D. Koutras, L. Di Biase, S. Beheiry, R. Hongo, R. Horton, K. Morganti, S. Hao, J. Javier Sanchez, A. Natale, G. Digby, B. Parfrey, F. Morriello, L. Lim, W. M. Hopman, C. S. Simpson, D. P. Redfearn, A. Baranchuk, T. Madsen, E. B. Schmidt, E. Toft, J. H. Christensen, D. Patel, M. Shaheen, K. Sonne, P. Mohanty, L. Dibiase, R. P. Horton, J. E. Sanchez, T. Krynski, S. M. Stec, A. Stanke, A. Baszko, P. Kulakowski, E. Rondano, M. Bortnik, E. Occhetta, G. Teodori, P. P. Caimmi, P. N. Marino, P. Osmancik, Z. Peroutka, D. Herman, P. Stros, P. Budera, Z. Straka, D. Petrac, V. Radeljic, D. Delic-Brkljacic, S. Manola, N. Pavlovic, G. Inama, C. Pedrinazzi, P. Adragao, F. Arribas, M. Landolina, J. L. Merino, J. De Sousa, M. Gulizia, P. Neuzil, F. Holy, J. Skoda, J. Petru, L. Sediva, S. Kralovec, J. Brada, M. Taborsky, M. Takami, A. Yoshida, K. Fukuzawa, K. Takami, H. Kumagai, S. Tanaka, M. Itoh, K. Hirata, F. Jacques, J. Champagne, D. Doyle, E. Charbonneau, F. Dagenais, P. Voisine, E. Dumont, A. Aboelhoda, M. Nawar, I. Khadragui, M. Loutfi, B. Ramadan, G. Makboul, L. Gianfranchi, F. Pacchioni, K. Bettiol, P. Alboni, R. Gallardo Lobo, R. Pap, G. Bencsik, A. Makai, G. Marton, L. Saghy, T. Forster, M. Stockburger, F. Trautmann, A. Nitardy, M. Just-Teetzmann, S. Schade, O. Celebi, A. Krebs, R. Dietz, C. A. Pastore, R. A. Douglas, N. Samesima, M. Martinelli Filho, S. A. D. Nishioka, A. Pastor Fuentes, J. Perea, N. Tur, B. Berzal, L. H. Boldt, M. Polotzki, M. G. Posch, A. Perrot, M. Lohse, S. Rolf, C. Ozcelik, W. Haverkamp, L. G. Tunyan, S. V. Grigoryan, A. Barsheshet, R. Abu Sham'a, R. Kuperstein, M. S. Feinberg, A. Sandach, D. Luria, M. Eldar, M. Glikson, R.- G. Vatasescu, A. Berruezo, C. Iorgulescu, A. Fruntelata, M. Dorobantu, A. Chaumeil, F. Philippon, G. O'hara, L. Blier, F. Molin, M. Gilbert, U. Paslawska, A. Noszczyk-Nowak, P. Skrzypczak, J. Nicpon, S. Chevallier, A. Van Oosterom, E. Pruvot, A. Iga, M. Igarashi, H. Itou, T. Fujino, T. Tsubota, J. Yamazaki, K. Yoshihara, P. Arsenos, K. Gatzoulis, P. Dilaveris, T. Gialernios, T. Papaioannou, K. Masoura, S. Archontakis, C. Stefanadis, G. M. Nasr, A. Khashaba, H. Osman, M. El-Barbary, M. Heinke, T. Heinke, B. Ismer, H. Kuehnert, R. Surber, and H. R. Figulla

Subjects
medicine.medical_specialty, business.industry, Physiology (medical), Medicine, Medical physics, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published
2009
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20. Well-defined radiolucent lesion in the maxillary anterior region

Author

Thomas R. Schott, Laurie Ruth Staretz, and Brian J. Brada

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Radiodensity, Radiography, Dentistry, Prosthesis, Asymptomatic, Anterior region, Lesion, parasitic diseases, medicine, Nasopalatine duct cyst, Humans, Cyst, Periodontitis, General Dentistry, business.industry, Palate, Middle Aged, medicine.disease, Nonodontogenic Cysts, Maxillary Diseases, Radiology, medicine.symptom, Nasal Cavity, business
Abstract

A case of nasopalatine duct cyst is described. Such cysts often remain asymptomatic for lengthy periods and may be discovered during routine radiography. The quiescent nature of this cyst underscores the importance of thorough clinical and radiographic examination before the fabrication of a prosthesis, as such cysts may give rise to acute infection, enlargement, and penetration through the overlying mucosa if not removed before denture insertion.

Published
1990

21. A structural econometric model of Czechoslovakia: 1954–1975

Author

A. E. King and J. Brada

Subjects
Statistics and Probability, Macroeconomics, Economics and Econometrics, Econometric model, Mathematics (miscellaneous), Planned economy, Economics, Social Sciences (miscellaneous)
Abstract

This paper describes an econometric model of the Czechoslovak economy. The model is based on a macroeconomic theory of the planned economy and the hypothesis that planners' behavior is relatively stable over time and reflects the policy options implied by the macroeconomic theory.

Published
1979
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22. The effect of electric fields on the luminescence and conductivity of ZnS single crystals

Author

I. T. Steinberger, J. Brada, V. Bar, and E. Alexander

Subjects
Physics, Condensed matter physics, Field (physics), Chemistry, General Chemistry, Conductivity, Condensed Matter Physics, Afterglow, Crystal, Impact ionization, Excited state, Electric field, Materials Chemistry, General Materials Science, Atomic physics, Luminescence, Excitation
Abstract

Application of a direct electric field (of the order of 104Vcm) causes a temporary increase of the luminescence of ZnS crystals (“Gudden-Pohl effect”). It is demonstrated that the light pulse is always accompanied by a current pulse. Studies of the effect showed that both pulses appear only if the crystal has been optically excited. The sizes and shapes of the pulses were systematically studied during the excitation, afterglow and thermal glow. Kinetic equations were set up, governing the free and trapped electron concentrations in the crystal. Most coefficients of these equations were experimentally determined by conventional luminescence and photoconductivity methods. Three different ways by which the field might cause release of electrons from traps, were considered: (a) tunneling from traps; (b) diminishing the effective trap depths by the field and thereby enhancing thermal release; (c) impact ionization of traps by accelerated conduction-band electrons. The kinetic equations showed that with either of these mechanisms current and light pulses appear, as observed in the experiments. However, tunneling (a) would yield completely negligible effects at even much higher fields than actually applied and is in disagreement with the experimental results on the dependence of the pulse heights on the state of excitation of the crystal. Mechanism (b) can account for the order of magnitude of the effects observed only if local fields, higher than the average one by a factor of about twenty exist in the crystal. It does not explain the observed behaviour of the pulses during the afterglow. Impact ionization (c) is in complete accord with the results on the dependence of the pulse heights on the state of excitation of the crystal but it also seems to need somewhat higher fields than the average fields applied.

Published
1964
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23. Magnetic resonance imaging in patients with a subcutaneous implantable cardioverter-defibrillator.

Author

Keller J, Neužil P, Vymazal J, Janotka M, Brada J, Žáček R, Vopálka R, Weichet J, and Reddy VY

Subjects
Adult, Aged, Aged, 80 and over, Artifacts, Electric Countershock adverse effects, Feasibility Studies, Female, Hot Temperature adverse effects, Humans, Male, Middle Aged, Predictive Value of Tests, Prosthesis Design, Prosthesis Failure, Risk Factors, Young Adult, Defibrillators, Implantable adverse effects, Electric Countershock instrumentation, Magnetic Resonance Imaging adverse effects
Abstract

Aims: Our aim was to evaluate the potential for safely imaging patients with a new type of implantable cardioverter-defibrillator called the subcutaneous implantable cardioverter-defibrillator (S-ICD) in a 1.5 T magnetic resonance imaging (MRI) scanner. With the increasing number of patients with cardiac implantable devices who are indicated for MRI, there is a growing need for establishing MRI compatibility of cardiac implantable devices., Methods and Results: Patients with implanted S-ICD systems underwent one or more types of anatomical MRI scans. The S-ICD was programmed off and patients were monitored throughout the imaging procedure. Device function was evaluated pre- and post-scan. Patients were asked to report immediately any pain, torqueing movement, or heating sensation in the area of the pocket or electrode. Fifteen patients underwent a total of 22 examinations at 1.5 T. Scans included brain, spine, knee, and heart. Two patients were re-scanned due to complaints of heating over the can during lumbar scans, which was caused by a thermistor probe placed on the skin to measure skin temperature. All the remaining scans occurred without incident. No evidence of device malfunction was observed., Conclusion: This study is the first to domonstrate the feasibility of exposing S-ICD patients to MRI using the scanning and monitoring protocol described. More data are required to support S-ICD as a MRI conditional device., (© The Author 2015. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2015
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24. [A comparison of two methods of long-term external ECG telemonitoring in patients after ablation for atrial fibrillation].

Author

Chovančík J, Bulková V, Fiala M, Gandalovičová J, Královec S, Neuwirth R, Tolaszová H, Jiravský O, Brada J, and Januška J

Subjects
Adult, Aged, Atrial Fibrillation physiopathology, Atrial Fibrillation surgery, Female, Humans, Male, Middle Aged, Recurrence, Atrial Fibrillation diagnosis, Catheter Ablation, Electrocardiography, Ambulatory, Telemetry
Abstract

Aim: The aim of the study was to compare two methods of long-term ECG monitoring after atrial fibrillation (AF) ablation., Methods: The study included 279 patients with paroxysmal (n = 163) or persistent (n = 116) AF, who were followed up for 1 year after the first catheter ablation for AF. All patients were provided with episodic ECG recorder for 1 year and instructed to send at least 2 random ECG recordings per day and whenever they sensed symptoms. They were also provided with external loop recorder for 2-3 weeks at 6 and 12 months to enable more continuous ECG monitoring., Results: At the end of 39 ± 12 (12-60) month follow-up, 143 (88%) patients with paroxysmal AF, and 105 (91%) patients with persistent AF, respectively, remained in stable sinus rhythm. The efficacy of episodic recorder expressed as a ratio of patients with identified AF/atrial tachycardia (AT) out of all patients with a documented episode of AF/AT was superior to the efficacy of loop recorder. No AF/AT episode was recorded with the loop recorder that was not also documented by the episodic recorder. Of the patients with the AF/AT recurrence detected by the episodic recorder, the arrhythmia was also revealed by the loop recorder in 70% of the patients after paroxysmal AF ablation (p < 0.001), and in 52% of the patients after persistent AF ablation (p = 0.006). Asymptomatic AF/AT was present in 42 (26%) of patients with paroxysmal AF, and in 28 (24%) patients with persistent AF (p = 0.810). From conventional follow-up unexpected and clinically significant episode of AF/AT that required change in therapy was detected in 9 (5.5%) patients after ablation for paroxysmal AF, and in 4 (3.4%) patients after ablation for persistent FS., Conclusion: More episodes of AF/AT after ablation were detected by 1-year daily ECG monitoring using episodic recorder as compared to periodic ECG monitoring with loop recorder. Identification of clinically significant episodes of AF/AT unrecognized from conventional follow-up was low.

Published
2012

25. Magnetic resonance imaging of the rat brain after epileptic seizures--preliminary results.

Author

Kuchar MZ, Jerábková P, Brada J, Kaspar J, Skrivan J, Betka J, and Langmeier M

Subjects
Animals, Epilepsy chemically induced, Kainic Acid, Rats, Rats, Wistar, Brain pathology, Diffusion Magnetic Resonance Imaging, Epilepsy pathology
Abstract

The magnetic resonance imaging (MRI) of the rat brain after the epilepsy seizures has been performed. As a first step, the model of the kainic acid (KA) induced seizures has been conducted to examine the possibilities of magnetic resonance imaging system kept in disposition. Seven Wistar albino rats, weighing about 300 g, were used in this study. We administered six of them with intraperitoneal injection of 10 mg/kg of KA. The control animal received corresponding volume of the saline. Every animal was examined under systemic anaesthesia induced by an intraperitoneal injection of thiopental sodium approximately 15 minutes before scanning. Diffusion-weighted imaging (DWI) has been used to acquire the coronary scans of the rat brain. The progress of hyper intense signal at the cerebral cortex and amygdale has been observed. Marked asymmetry of the signal intensity between hemispheres has been discovered. Subsequently the experimental model of audiogenic epilepsy will be conducted.

Published
2006

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