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1. A note on the complexity of scheduling of communication-aware directed acyclic graph

Author: J. Musial, M. Guzek, P. Bouvry, and J. Blazewicz
Subjects: computational complexity, models in cloud computing, communication-aware cloud computing, directed acyclic graphs, np-hardness in cloud computing, Technology, Technology (General), T1-995
Published: 2018
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2. Multimodal assessment of right ventricle overload-metabolic and clinical consequences in pulmonary arterial hypertension

Author: Remigiusz Kazimierczyk, Lukasz A. Malek, Piotr Szumowski, Stephan G. Nekolla, Piotr Blaszczak, Dorota Jurgilewicz, Marcin Hladunski, Bozena Sobkowicz, Janusz Mysliwiec, Ryszard Grzywna, Wlodzimierz J. Musial, and Karol A. Kaminski
Subjects: Primary pulmonary hypertension, Cardiovascular magnetic resonance, Positron emission tomography, Prognosis, Coupling, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract: Abstract Background In pulmonary arterial hypertension (PAH) increased afterload leads to adaptive processes of the right ventricle (RV) that help to maintain arterio-ventricular coupling of RV and preserve cardiac output, but with time the adaptive mechanisms fail. In this study, we propose a multimodal approach which allows to estimate prognostic value of RV coupling parameters in PAH patients. Methods Twenty-seven stable PAH patients (49.5 ± 15.5 years) and 12 controls underwent cardiovascular magnetic resonance (CMR). CMR feature tracking analysis was performed for RV global longitudinal strain assessment (RV GLS). RV-arterial coupling was evaluated by combination of RV GLS and three proposed surrogates of RV afterload—pulmonary artery systolic pressure (PASP), pulmonary vascular resistance (PVR) and pulmonary artery compliance (PAC). 18-FDG positron emission tomography (PET) analysis was used to assess RV glucose uptake presented as SUVRV/LV. Follow-up time of this study was 25 months and the clinical end-point was defined as death or clinical deterioration. Results Coupling parameters (RV GLS/PASP, RV GLS/PVR and RV GLS*PAC) significantly correlated with RV function and standardized uptake value (SUVRV/LV). Patients who experienced a clinical end-point (n = 18) had a significantly worse coupling parameters at the baseline visit. RV GLS/PASP had the highest area under curve in predicting a clinical end-point and patients with a value higher than (−)0.29%/mmHg had significantly worse prognosis. It was also a statistically significant predictor of clinical end-point in multivariate analysis (adjusted R2 = 0.68; p
Published: 2021
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3. The rs2228145 polymorphism in the interleukin-6 receptor and its association with long-term prognosis after myocardial infarction in a pilot study

Author: Anna Szpakowicz, Witold Pepinski, Ewa Waszkiewicz, Małgorzata Skawronska, Anna Niemcunowicz-Janica, Wlodzimierz J. Musial, and Karol A. Kaminski
Subjects: interleukin-6, IL-6 receptor, ST elevation myocardial infarction, acute coronary syndrome, Medicine
Abstract: Introduction : Interleukin-6 (IL-6) is a cytokine with a complex function that is described as both pro- and anti-inflammatory. One factor that influences its function is the rs2228145 A/C single nucleotide polymorphism (SNP) of the IL-6 receptor (IL6R) gene. C allele carriers have a decreased inflammatory response and decreased prevalence of ischemic heart disease. The aim of the study was to investigate the association of the rs2228145 SNP of the IL6R gene with long-term total mortality in patients with ST-elevation myocardial infarction (STEMI) treated invasively. Material and methods : We analyzed the data of consecutive patients with ST elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). Genotyping was performed with the TaqMan method. The analyzed end-point was total long-term mortality (median: 2875 days). Results: The registry comprised 553 patients (mean age: 62.4 ±11.9 years; 25.6% females, n = 142; TIMI 3 obtained in 91.7% of patients, n = 507). No significant differences in baseline characteristics were found between the genotypes. During long-term follow-up 171 (30.9%) patients died. There was non-significantly higher mortality in the rs2228145 AA homozygotes compared to C allele carriers (OR = 1.34, 95% CI: 0.93–1.93, p = 0.1). Conclusions : The rs2228145 polymorphism of IL6R was not significantly associated with long-term mortality after STEMI. However, AA homozygotes (high-risk genotype for ischemic heart disease) showed a trend towards adverse outcome compared to C allele carriers. The observed trend is promising, but it requires independent replication studies.
Published: 2016
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4. Initial Invasive or Conservative Strategy for Stable Coronary Disease

Author: Maron D. J., Hochman J. S., Reynolds H. R., Bangalore S., O'Brien S. M., Boden W. E., Chaitman B. R., Senior R., Lopez-Sendon J., Alexander K. P., Lopes R. D., Shaw L. J., Berger J. S., Newman J. D., Sidhu M. S., Goodman S. G., Ruzyllo W., Gosselin G., Maggioni A. P., White H. D., Bhargava B., Min J. K., John Mancini G. B., Berman D. S., Picard M. H., Kwong R. Y., Ali Z. A., Mark D. B., Spertus J. A., Krishnan M. N., Elghamaz A., Moorthy N., Hueb W. A., Demkow M., Mavromatis K., Bockeria O., Peteiro J., Miller T. D., Szwed H., Doerr R., Keltai M., Selvanayagam J. B., Gabriel Steg P., Held C., Kohsaka S., Mavromichalis S., Kirby R., Jeffries N. O., Harrell F. E., Rockhold F. W., Broderick S., Bruce Ferguson T., Williams D. O., Harrington R. A., Stone G. W., Rosenberg Y, ISCHEMIA Research Group: Joseph Ricci, A Tello Montoliu, A I Robero Aniorte, Abbey Mulder, Abhay A Laddu, Abhinav Goyal, Abhishek Dubey, Abhishek Goyal, Abigail Knighton, Abraham Oomman, Adam J Jaskowiak, Adam Kolodziej, Adam Witkowski, Adnan Hameed, Adriana Anesini, Afshan Hussain, Agne Juceviciene, Agne Urboniene, Agnes Jakal, Agnieszka Szramowska, Ahmad Khairuddin, Ahmed Abdel-Latif, Ahmed Adel, Ahmed Aljzeeri, Ahmed Kamal, Ahmed Talaat, Aimee Mann, Aira Contreras, Ajit Kumar, V K Kumar, Akemi Furukawa, Akshay Bagai, Akvile Smigelskaite, Alain Furber, Alain Rheault, Alaine Melanie Loehr, Alan Rosen, Albert Varga, Albertina Qelaj, Alberto Barioli, Aldo Russo, Alec Moorman, Alejandro Gisbert, Aleksandra Fratczak, Aleksandras Laucevicius, Alena Kuleshova, Alessandro Sionis, Alexander A Sirker, Alexander M Chernyavskiy, Alexandra Craft, Alexandra Vazquez, Alexandre Ciappina Hueb, Alexandre S Colafranseschi, Alexandre Schaan de Quadros, Alexandre Tognon, Ali Alghamdi, Alice Manica Muller, Aline Nogueira Rabaça, Aline Peixoto Deiro, Alison Hallam, Allegra Stone, Allison Schley, Almudena Castro, Alvaro Rabelo Ales, Amanda Germann, Amanda O'Malley, Amar Uxa, Amarachi Ojajuni, Amarino C Oliveira Jr, Amber B Hull, Ambuj Roy, Amer Zarka, Amir Janmohamed, Ammani Brown, Ammy Malinay, Amparo Martinez Monzonis, Amy J Richards, Amy Iskandrian, Amy Ollinger, Ana D Djordjevic-Dikic, Ana Fernández Martínez, Ana Gomes Almeida, Ana Paula Batista, Ana Rita Francisco, Ana S Mladenovic, Ana Santana, Anam Siddiqui, Anastasia M Kuzmina-Krutetskaya, Andras Vertes, Andre S Sousa, Andre Gabriel, André Schmidt, Andrea M Lundeen, Andrea Bartykowszki, Andrea Lorimer, Andrea Mortara, Andrea Pascual, Andreia Coelho, Andreia Rocha, Andrés García-Rincón, Andrew G Howarth, Andrew J Moriarty, Andrew Docherty, Andrew Starovoytov, Andrew Zurick, Andrzej Łabyk, Andrzej Swiatkowski, Andy Lam, Anelise Kawakami, Angela Hoye, Angela Kim, Angelique Smit, Angelo Nobre, Anil V Shah, Anja Ljubez, Anjali Anand, Ankush Sachdeva, Ann Greenberg, Ann Luyten, Ann Ostrander, Anna Di Donato, Anna Cichocka-Radwan, Anna Fojt, Anna Plachcinska, Anna Proietti, Anna Teresinska, Anne Marie Webb, Anne Cartwright, Anne Heath, Anne Mackin, Anong Amaritakomol, Anong Chaiyasri, Anoop Chauhan, Anoop Mathew, Anthony Gemignani, Anto Luigi Andres, Antonia Vega, Antonietta Hansen, Antonino Ginel Iglesias, Antonio Carlos Carvalho, Antonio Di Chiara, Antonio Serra Peñaranda, Antonio Carvalho, Antonio Colombo, Antonio Fiarresga, Anupama Rao, Aquiles Valdespino-Estrada, Araceli Boan, Areef Ishani, Ariel Diaz, Arijit Ghosh, Arintaya Prommintikul, Arline Roberts, Arnold H Seto, Arnold P Good, Arshed Quyyumi, Arthur J Labovitz, Arthur Kerner, Arturo S Campos-Santaolalla, Arunima Misra, Ashok Mukherjee, Ashok Seth, Ashraf Seedhom, Asim N Cheema, Asker Ahmed, Atul Mathur, Atul Verma, Audrey W Leong, Axel Åkerblom, Axelle Fuentes, Aynun Naher, Badhma Valaiyapathi, Baljeet Kaur, Bandula Guruge, Barbara Brzezińska, Barbara Nardi, Bartosz Czarniak, Bebek Singh, Begoña Igual, Bela Merkely, Belen Cid Alvarez, Benjamin J Spooner, Benjamin J W Chow, Benjamin Cheong, Benoy N Shah, Bernard de Bruyne, Bernardas Valecka, Bernhard Jäger, Beth A Archer, Beth Abramson, Beth Jorgenson, Bethany Harvey, Betsy O'Neal, Bev Atkinson, Bev Bozek, Bevin Lang, Bijulal Sasidharan, Bin Yang, Bin Zhang, Binoy Mannekkattukudy Kurian, Bjoern Goebel, Bob Hu, Bogdan A Popescu, Bogdan Crnokrak, Bolin Zhu, Bonnie J Kirby, Brandi D Zimbelman, Brandy Starks, Branko D Beleslin, Brenda Hart, Brian P Shapiro, Brian McCandless, Brianna Wisniewski, Brigham R Smith, Brooks Mirrer, Bruce McManus, Bruce Rutkin, Bruna Edilena Paulino, Bruna Maria Ascoli, Bryn Smith, Byron J Allen, C Michael Gibson, C Noel Bairey Merz, Calin Pop, Cameron Hague, Camila Thais de Ormundo, Candace Gopaul, Candice P Edillo, Carísi A Polanczyk, Carita Krannila, Carla Vicente, Carl-Éric Gagné, Carlo Briguori, Carlos Peña Gil, Carlos Alvarez, Carly Ohmart, Carmen C Beladan, Carmen Ginghina, Carol M Kartje, Caroline Alsweiler, Caroline Brown, Caroline Callison, Caroline Pinheiro, Caroline Rodgers, Caroline Spindler, Carolyn Corbett, Carrie Drum, Casey Riedberger, Catherine Bone, Catherine Fleming, Catherine Gordon, Catherine Jahrsdorfer, Catherine Lemay, Catherine Weick, Cathrine Patten, Cecilia Goletto, Cezary Kepka, Chandini Suvarna, Chang Xu, Chantale Mercure, Charle A Viljoen, Charlene Wiyarand, Charles Jia-Yin Hou, Charles Y Lui, Charles Cannan, Charles Cornet, Charlotte Pirro, Chataroon Rimsukcharoenchai, Chen Wang, Cheng-Ting Tsai, Chen-Yen Chien, Cheryl A Allardyce, Chester M Hedgepeth, Chetan Patel, Chiara Attanasio, Chih-Hsuan Yen, Chi-Ming Chow, Ching Min Er, Ching-Ching Ong, Cholenahally Nanjappa Manjunath, Chris Beck, Chris Buller, Christel Vassaliere, Christian Hamm, Christiano Caldeira, Christie Ballantyne, Christina Björklund, Christine R Hinton, Christine Bergeron, Christine Masson, Christine Roraff, Christine Shelley, Christophe Laure, Christophe Thuaire, Christopher Kinsey, Christopher McFarren, Christopher Spizzieri, Christopher Travill, Chun-Chieh Liu, Chung-Lieh Hung, Chunguang Li, Chun-Ho Yun, Chunli Xia, Ciarra Heard, Cidney Schultz, Clare Venn-Edmonds, Claudia P Hochberg, Claudia Wegmayr, Claudia Cortés, Claudia Escobar, Cláudia Freixo, Claudio T Mesquita, Clemens T Kadalie, Colin Berry, Constance Philander, Corine Thobois, Costantino Costantini, Courtney Page, Craig Atkinson, Craig Barr, Craig Paterson, Cristina Bare, Cynthia Baumann, Cynthia Burman, Dalisa Espinosa, Damien Collison, Dan Deleanu, Dan Elian, Dan Gao, Dana Oliver, Daniel P Vezina, Daniel O'Rourke, Daniele Komar, Danielle Schade, Darrel P Francis, Dastan Malaev, David A Bull, David E Winchester, David P Faxon, David Booth, David Cohen, David DeMets, David Foo, David Schlichting, David Taggart, David Waters, David Wohns, Davis Vo, Dawid Teodorczyk, Dawn Shelstad, Dawn Turnbull, Dayuan Li, Dean Kereiakes, Deborah O'Neill, Deborah Yip, Debra K Johnson, Debra Dees, Deepak L Bhatt, Deepika Gopal, Deepti Kumar, Deirdre Mattina, Deirdre Murphy, Delano R Small, Delsa K Rose, Dengke Jiang, Denis Carl Phaneuf, Denise Braganza, Denise Fine, Derek Cyr, Desiree Tobin, Diana Cukali, Diana Parra, Diane Camara, Diane Minshall Liu, Diego Adrián Vences, Diego Franca de Cunha, Dimitrios Stournaras, Dipti Patel, Dongze Li, Donna Exley, Dorit Grahl, Dragana Stanojevic, Duarte Cacela, Dwayne S G Conway, E Pinar Bermudez, Eapen Punnoose, Edgar L Tay, Edgar Karanjah, Edoardo Verna, Eduardo Hernandez-Rangel, Edward D Nicol, Edward O McFalls, Edward T Martin, Edyta Kaczmarska, Ekaterina I Lubinskaya, Elena A Demchenko, Elena Refoyo Salicio, Eli Feen, Elihú Durán-Cortés, Elisabeth M Janzen, Elise L Hannemann, Elise van Dongen, Elissa Restelli Piloto, Eliza Kaplan, Elizabeta Srbinovska Kostovska, Elizabeth Capasso-Gulve, Elizabeth Congdon, Elizabeth Ferguson, Elizaveta V Zbyshevskaya, Ellen Magedanz, Ellie Fridell, Ellis W Lader, Elvin Kedhi, Emanuela Racca, Emilie Tachot, Emily DeRosa, Encarnación Alonso-Álvarez, Eric Nicollet, Eric Peterson, Erick Alexánderson Rosas, Erick Donato Morales, Erin Orvis, Ermina Moga, Estelle Montpetit, Estevao Figueiredo, Eugene Passamani, Eugenia Nikolsky, Eunice Yeoh, Evgeniy I Kretov, Ewa Szczerba, Ewelina Wojtala, Expedito Eustáquio Ribeiro Silva, F Marin Ortuño, Fabio R Farias, Fabio Fimiani, Fabrizio Rolfo, Fa-Chang Yu, Fadi Hage, Fadi Matar, Fahim Haider Jafary, Fang Feng, Fang Liu, Fatima Ranjbaran, Fatima Rodriguez, Fausto J Pinto, Fauzia Rashid, Federica Ramani, Fei Wang, Fernanda Igansi, Filipa Silva, Filippo Ottani, Fiona Haines, Firas Al Solaiman, Flávia Egydio, Flavio Lyra, Florian Egger, Fran Farquharson, Frances Laube, Francesc Carreras Costa, Francesca de Micco, Francesca Bianchini, Francesca Pezzetta, Francesca Pietrucci, Francesco Orso, Francesco Pisano, Francis Burt, Francisca Patuleia Figueiras, Francisco Fernandez-Aviles, Francois Pierre Mongeon, Frans Van de Werf, Franziska Guenther, Fraser N Witherow, Fred Mohr, Frederico Dall'Orto, Fumiyuki Otsuka, G De La Morena, G Karthikeyan, Gabor Dekany, Gabor Kerecsen, Gabriel Galeote, Gabriel Grossmann, Gabriel Vorobiof, Gabriela Sanchez de Souza, Gabriela Guzman, Gabriela Zeballos, Gabriele Gabrielli, Gabriele Jakl-Kotauschek, Gail A Shammas, Gail Brandt, Gang Chen, Gary E Lane, Gary J Luckasen, Gautam Sharma, Gelmina Mikolaitiene, Gennie Yee, Georg Nickenig, George E Revtyak, George J Juang, Gerald Fletcher, Gerald Leonard, Gerard Patrick Devlin, Gerard Esposito, Gergely Ágoston, Gervasio Lamas, Geza Fontos, Ghada Mikhail, Gia Cobb, Gian Piero Perna, Gianpiero Leone, Giles Roditi, Gilles Barone-Rochette, Girish Mishra, Giuseppe Tarantini, Glenda Wong, Glenn S Hamroff, Glenn Rayos, Gong Cheng, Gonzalo Barge-Caballero, Goran Davidović, Goran Stankovic, Gordana Stevanovic, Grace Jingyan Wang, Grace M Young, Graceanne Wayser, Graciela Scaro, Graham S Hillis, Graham Wong, Grazyna Anna Szulczyk, Gregor Simonis, Gregory Kumkumian, Gretchen Ann Peichel, Grzegorz Gajos, Gudrun Steinmaurer, Guilherme G Rucatti, Guilherme Portugal, Guilhermina Cantinho Lopes, Guillem Pons Lladó, Gunnar Frostfelt, Gurpreet S Wander, Gurpreet Gulati, Gustavo Pucci, Hafidz Abd Hadi, Haibo Zhang, Haitao Wang, Halina Marciniak, Han Chen, Hanan Kerr, Hani Najm, Hanna Douglas, Hannah Phillips, Hao Dai, Haojian Dong, Haqeel Jamil, Harikrishnan Sivadasanpillai, Harry Suryapranata, Hassan Reda, Hayley Pomeroy, Heather Barrentine, Heather Golden, Heather Hurlburt, Heidi Wilson, Helen C Tucker, Helene Abergel, Hemalata Siddaram, Hermine Osseni, Herwig Schuchlenz, Hesong Zeng, Hicham Skali, Hilda Solomon, Hollie Horton, Holly Hetrick, Holly Little, Holly Park, Hongjie Chi, Hossam Mahrous, Howard A Levite, Hristo Pejkov, Huajun Li, Hugo Bloise-Adames, Hugo Marques, Hui Zhong, Hui-Min Zhang, Humayrah Hashim, Hung-I Yeh, Hussien El Fishawy, Ian Webb, Iftikhar Kullo, Igor O Grazhdankin, Ihab Hamzeh, Ikraam Hassan, Ikuko Ueda, Ileana L Pina, Ilona Tamasauskiene, Ilse Bouwhuis, Imran Arif, Ina Wenzelburger, Inês Zimbarra Cabrita, Ines Rodrigues, Inga H Robbins, Inga Soveri, Ingela Schnittger, Iqbal Karimullah, Ira M Dauber, Iram Rehman, Irena Peovska Mitevska, Irene Marthe Lang, Irina Subbotina, Irma Kalibataite-Rutkauskiene, Irni Yusnida, Isabel Estela Carvajal, Isabella C Palazzo, Isabelle Hogan, Isabelle Roy, Ishba Syed, Ishita Tejani, Ivan A Naryshkin, Ivana Jankovic, Iwona Niedzwiecka, J David Knight, Jacek Kusmierek, Jackie M White, Jackie Chow, Jacob Udell, Jacqueline E Tamis-Holland, Jacqueline Fannon, Jacquelyn A Quin, Jacquelyn Do, Jaekyeong Heo, Jakub Maksym, James E Davies, James H O'Keefe Jr, James J Jang, James Cha, James Harrison, James Hirsch, James Stafford, James Tatoulis, Jamie Rankin, Jan Henzel, Jan Orga, Jana Tancredi, Janaina Oliveira, Jane Burton, Jane Eckstein, Jane Marucci, Janet P Knight, Janet Blount, Janet Halliday, Janetta Kourzenkova, Janitha Raj, Jan-Malte Sinning, Jaqueline Pozzibon, Jaroslaw Drozdz, Jaroslaw Karwowski, Jason D Glover, Jason Loh Kwok, Jason T Call, Jason Linefsky, Jassira Gomes, Jati Anumpa, Javier J Garcia, Javier Courtis, Jay Meisner, K Jayakumar, Jayne Scales, Jean E Denaro, Jean Michel Juliard, Jean Ho, Jeanette K Stansborough, Jean-Michel Juliard, Jeanne Russo, Jeannette J M Schoep, Jeet Thambyrajah, Jeff Leimberger, Jeffery A Breall, Jeffrey A Kohn, Jeffrey C Milliken, Jeffrey Anderson, Jeffrey Blume, Jeffrey Kanters, Jeffrey Lorin, Jeffrey Moses, Jelena J Stepanovic, Jelena Celutkiene, Jelena Djokic, Jelena Stojkovic, Jenne M Jose, Jenne Manchery, Jennifer A Mull, Jennifer H Czerniak, Jennifer L Stanford, Jennifer Gillis, Jennifer Horst, Jennifer Isaacs, Jennifer Langdon, Jennifer Thomson, Jennifer Tomfohr, Jennifer White, Jen-Yuan Kuo, Jeremy Rautureau, Jerome Fleg, Jessica Berg, Jessica Rodriguez, Jessica Waldron, Jhina Patro, Jia Li, Jiajia Mao, Jiamin Liu, Jian'an Wang, Jianhua Li, Jianxin Zhang, Jie Qi, Jihyun Lyo, Jill Marcus, Jim Blankenship, Jing Zhang, Jingjing Liu, Jing-Yao Fan, Jiun-Yi Li, Jiwan Pradhan, Jiyan Chen, J M Rivera Caravaca, Jo Evans, Joan Garcia Picart, Joan Hecht, Joanna Jaroch, Joanna Zalewska, Joanne Kelly, Joanne Taaffe, João Reynaldo Abbud, João V Vitola, Joaquín V Peñafiel, Jocelyne Benatar, Jody Bindeman, Joe Sabik, Joel Klitch, Johann Christopher, Johannes Aspberg, John D Friedman, John F Beltrame, John F Heitner, John Joseph Graham, John R Davies, John Doan, John Kotter, John Kurian, John Mukai, John Pownall, Jolanta Sobolewska, Jon Kobashigawa, Jonathan L Goldberg, Jonathan W Bazeley, Jonathan Byrne, Jonathan Himmelfarb, Jonathan Leipsic, Jonean Thorsen, Jorge F Trejo Gutierrez, Jorge Escobedo, Jorik Timmer, José A Ortega-Ramírez, José Antonio Marin-Neto, Jose D Salas, Jose Enrique Castillo, Jose Francisco Saraiva, José J Cuenca-Castillo, Jose L Diez, José Luis Narro Villanueva, José Luiz da Vieira, José M Flores-Palacios, Jose Ramon Gonzalez, Jose Seijas Amigo, Jose Fragata, Josep Maria Padró, Josheph F X McGarvey Jr, Joseph Hannan, Joseph Sacco, Joseph Sweeny, Joseph Wiesel, Josephine D Abraham, Joshua P Loh, Joy Burkhardt, Joyce R White, Joyce Riestenberg-Smith, Judit Sebo, Judith L Meadows, Judith Wright, Judy Mae Foltz, Judy Hung, Judy Otis, Juergen Stumpf, Jui-Peng Tsai, Julia S Dionne, Julia de Aveiro Morata, Julie Bunke, Julie Morrow, Julio César Figal, Jun Fujita, Jun Jiang, Junhua Li, Junqing Yang, Juntima Euathrongchit, Jyotsna Garg, K Manjula Rani, K Preethi, Kaatje Goetschalckx, Kai Eggers, Kamalakar Surineni, Kanae Hirase, T R Kapilamoorthy, Karen Calfas, Karen Gratrix, Karen Hallett, Karen Hultberg, Karen Nugent, Karen Petrosyan, Karen Swan, Karolina Kryczka, Karolina Wojtczak-Soska, Karolina Wojtera, Karsten Lenk, Karthik Ramasamy, Katarzyna Łuczak, Katarzyna Malinowska, Kate Pointon, Kate Robb, Katherine Martin, Kathleen Claes, Kathryn Carruthers, Kathy E Siegel, Katia Drouin, Katie Fowler-Lehman, Kavita Rawat, Kay Rowe, Keiichi Fukuda, Keith A A Fox, Ken Mahaffey, Kendra Unterbrink, Kenneth Giedd, Kerrie Van Loo, Kerry Lee, Kerstin Bonin, Kevin R Bainey, Kevin T Harley, Kevin Anstrom, Kevin Chan, Kevin Croce, Kevin Landolfo, Kevin Marzo, Keyur Patel, Khaled Abdul-Nour, Khaled Alfakih, Khaled Dajani, Khaled Ziada, Khaula Baloch, Khrystyna Kushniriuk, Kian-Keong Poh, Kim F Ireland, Kim Holland, Kimberly Ann Byrne, Kimberly E Halverson, Kimberly Elmore, Kimberly Miller-Cox, Kiran Reddy, Kirsten J Quiles, Kirsty Abercrombie, Klaus Matschke, Konrad Szymczyk, Koo Hui Chan, Kotiboinna Preethi, Kozhaya Sokhon, Krissada Meemuk, Kristian Thygesen, Kristin M Salmi, Kristin Newby, Kristina Wippler, Kristine Arges, Kristine Teoh, Krystal Etherington, Krystyna Łoboz-Grudzień, Krzysztof W Reczuch, Krzysztof Bury, Krzysztof Drzymalski, Krzysztof Kukuła, Kuo-Tzu Sung, Kurt Huber, Ladda Douangvila, Lance Sullenberger, Larissa Miranda Trama, Laszlone Matics, Laura Drew, Laura Flint, Laura Keinaite, Laura Sarti, Laurel Kolakaluri, Lawrence M Phillips, Lawrence Friedman, Lawrence Phillips, Lazar Velicki, Leah Howell, Leandro C Maranan, Leanne Cox, Ledjalem Daba, Lei Zhang, Lekshmi Dharmarajan, Leo Bockeria, Leonardo Pizzol Caetano, Leonardo Bridi, Leonid L Bershtein, Leszek Sokalski, Li Hai Yan, Li Li, Lia Nijmeijer, Lidia Sousa, Lihong Xu, Lihua Zhang, Lili Zhang, Lilia Schiavi, Lilian Mazza Barbosa, Lillian L Khor, Lina Felix-Stern, Linda L Hall, Linda M Hollenweger, Linda Arcand, Linda Davidson-Ray, Linda Schwarz, Lindsey N Sikora, Lingping Chi, Lino Patricio, Liping Zhang, Lisa Chaytor, Lisa Hatch, Lisa McCloy, Lisa Wong, Liselotte Persson, Lixin Jiang, Liz Low, Ljiljana Pupic, Loïc Bière, Lorenzo Monti, Lori Christensen, Lori Pritchard, Loriane Black, Lori-Ann Desimone, Lori-Ann Larmand, Lorraine McGregor, Louise Morby, Louise Thomson, Luc Harvey, Luciana de Pádua Baptista, Lucilla Garcia, Ludivine Eliahou, Ludmila Helmer, Luis F Smidt, Luis Bernanrdes, Luis Guzman, Luiz A Carvalho, Luyang Xiong, Lynette L Teo, Lynn M Neeson, Lynne Winstanley, M Barbara Srichai-Parsia, M Quintana Giner, M Sowjanya Reddy, M Valdés Chávarri, M Grazia Rossi, Maarten Simoons, Maayan Konigstein, Maciej Lesiak, Maciej Olsowka, Mafalda Selas, Magalie Corfias, Magdalena Madero Rovalo, Magdalena Łanocha, Magdalena Miller, Magdalena Misztal-Teodorczyk, Magdalena Rantinella, Magdy Abdelhamid, Magnolia Jimenez, Mahboob Alam, Mahevamma Mylarappa, Mahfouz El Shahawy, Mahmoud Mohamed, Mahmud Al-Bustami, Majo X Joseph, Malgorzata Frach, Małgorzta Celińska-Spodar, Malte Helm, Manas Chacko, Mandy Murphy, Manitha Vinod, Manjula Rani, Manu Dhawan, Manuela Mombelli, Marcel Weber, Marcello Galvani, Marcelo Jamus Rodrigues, Marcia F Dubin, Marcia F Werner Bayer, Marcin Szkopiak, Marco Antonio Monsalve, Marco Bizzaro Santos, Marco Magnoni, Marco Marini, Marco Sicuro, Marco Zenati, Marcos Valério Coimbra Resende, Marek Roik, Margalit Bentzvi, Margaret Gilsenan, Margaret Iraola, Margot C Quinn, Maria A Alfonso, Maria Antonieta Pereira Moraes, María Dolores Martínez-Ruíz, María Fernanda Canales, Maria Inês Caetano, Maria P Corral, Maria Pérez García, Maria Victoria Actis, Maria Aguirre, Maria Andreasson, Maria Aprile, Maria Colton, Maria Eugenia Martin, Maria Lasala, Maria Lorenzo, Maria Posada, Maria Shier, Maria Thottam, Mariana V Furtado, Mariana Yumi Okada, Marianna D A Dracoulakis, Marianne De Andrade, Mariano Rubio, Marie Essermark, Marielle Scherrer-Crosbie, Marija T Petrovic, Marija Zdravkovic, Marilyn Black, Marina Garcia, Mario J Garcia, Mariola Szulik, Marisa Orgera, Mark A de Belder, Mark Harbinson, Mark Hyun, Mark Peterson, Mark Xavier, Marlowe Mosley, Marta Capinha, Marta Marcinkiewicz-Siemion, Marta Swiderek, Martha Meyer, Martina Ceseri, Martina Tricoli, Marvin Kronenberg, Mary Williams, Mary Ann Champagne, Mary Colleen Rogge, Mary R Soltau, Mary Streif, Massimo Villella, Massoud Leesar, Matei Claudia, Mateusz Solecki, Matías Nicolás Mungo, Matthew Wall Jr, Matthew Budoff, Matthew Jezior, Matthew Luckie, Matthias Friedrich, Mauren P Haeffner, Maximilian Tscharre, Max-Paul Winter, Mayana Almeida, Mayil S Krishnam, Mayuri Patel, Meenakshi Mishra, Megan Manocchia, Meghana Kakade, Melanie J Munro, Melissa D Chaplin, Melissa LeFevre, Mervyn Andiapen, Michael A Gibson, Michael B Rubens, Michael C Turner, Michael D Shapiro, Michael W Lee, Michael Berlowitz, Michael Davidson, Michael Mack, Michael McDaniel, Michael Mumma, Michal Wlodarczyk, Michel G Khouri, Michel S Slama, Michele Rawlins, Michelle M Bonner, Michelle M Seib, Michelle Chang, Michelle Crowder, Michelle Dixon, Michelle Mayon, Michelle McEvoy, Michelle Yee, Miguel M Fernandes, Miguel Nobre Menezes, Miguel Souto Bayarri, Miguel Barrero, Mikhail T Torosoff, Milan R Dobric, Milan Dobric, Milica Nikola Dekleva, Milind Avdhoot Gadkari, Millie Gomez, Min Tun Kyaw, Miriam Brooks, Miroslav Stevo Martinovic, Mitchel B Lustre, Mohammad Tariq Vakani, Mohammad El-Hajjar, Mohammed Al-Amoodi, 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Paula García-González, Paulo Cury Rezende, Paulo Ricardo Caramori, Pavel S Kozlov, Pedro Canas Silva, Pedro Gabriel Melo Barros E Silva, Pedro Píccaro de Oliveira, Pedro Carvalho, Pedro Modas, Pedro Rio, Peeyush Jain, Peiyu He, Peter A McCullough, Peter H Stone, Peter M Pollak, Peter Douglass, Peter Henriksen, Peter OKane, Peter Ong, Philip Jones, Philip Rogal, Philippe Généreux, Philippe Menasche, Philippe Rheault, Phoebe Goold, Pierre Gervais, Pierre Michaud, Pilar Calvillo, Ping Chai, Piotr Jakubowski, Piotr Pruszczyk, Piotr Slomka, Piyamitr Sritara, Poay-Huan Loh, Poonam Sonawane, Pouneh Samadi, Pragnesh P Parikh, Prakash Deedwania, Pranav M Patel, Praneeth Polamuri, Pratiksha Sharma, Precilia Vasquez, Preeti Kamath, Prince Thomas, Priyadarshani Arambam, Puja K Mehta, Purvez Grant, Pushpa Naik, Qi Zhong, Qian Zhao, Qiang Zhou, Qianqian Yuan, Qin Yu, Qingxian Li, Qiulan Xie, Qiutang Zeng, R J Vindhya, R James Gerlach, Rachel King, Rada Vučić, Radmila Lyubarova, Radoslaw Pracon, 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Wu, Yu Kunwu, Yu Zhao, Yudong Peng, Yueh-Hung Lin, Yulan Zhao, Yumei Dong, Yunhai Zhao, Yutthaphan Wannasopha, Yvonne Taul, Zakir Sahul, Zalina Kudzoeva, Zbigniew Kalarus, Zeljko Z Markovic, Zhen Huang, Zheng Ji, Zhenyu Liu, Zhou Yue, Zhulin Zhang, Zhuxi Li, Zile Singh Meharwal, Ziliang Bai, Zixiang Yu, Zohra Huda, Zoltan Davidovits
Subjects: Male, Cardiac Catheterization, Computed Tomography Angiography, medicine.medical_treatment, Myocardial Ischemia, Coronary Disease, Coronary Artery Disease, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Coronary Angiography, ISCHEMIA Research Group, law.invention, Angina, Coronary artery disease, 0302 clinical medicine, Randomized controlled trial, law, Cardiovascular Disease, Myocardial Revascularization, 030212 general & internal medicine, Coronary Artery Bypass, 11 Medical and Health Sciences, Cardiac catheterization, General Medicine, Middle Aged, humanities, Cardiovascular Diseases, Cardiology, Female, Human, medicine.medical_specialty, Ischemia, Article, 03 medical and health sciences, Geriatric cardiology, Percutaneous Coronary Intervention, General & Internal Medicine, Internal medicine, medicine, Humans, Angina, Unstable, Aged, business.industry, Coronary Artery Bypa, Percutaneous coronary intervention, Bayes Theorem, medicine.disease, Heart failure, Quality of Life, business
Abstract: BACKGROUND: Among patients with stable coronary disease and moderate or severe ischemia, whether clinical outcomes are better in those who receive an invasive intervention plus medical therapy than in those who receive medical therapy alone is uncertain. METHODS: We randomly assigned 5179 patients with moderate or severe ischemia to an initial invasive strategy (angiography and revascularization when feasible) and medical therapy or to an initial conservative strategy of medical therapy alone and angiography if medical therapy failed. The primary outcome was a composite of death from cardiovascular causes, myocardial infarction, or hospitalization for unstable angina, heart failure, or resuscitated cardiac arrest. A key secondary outcome was death from cardiovascular causes or myocardial infarction. RESULTS: Over a median of 3.2 years, 318 primary outcome events occurred in the invasive-strategy group and 352 occurred in the conservative-strategy group. At 6 months, the cumulative event rate was 5.3% in the invasive-strategy group and 3.4% in the conservative-strategy group (difference, 1.9 percentage points; 95% confidence interval [CI], 0.8 to 3.0); at 5 years, the cumulative event rate was 16.4% and 18.2%, respectively (difference, -1.8 percentage points; 95% CI, -4.7 to 1.0). Results were similar with respect to the key secondary outcome. The incidence of the primary outcome was sensitive to the definition of myocardial infarction; a secondary analysis yielded more procedural myocardial infarctions of uncertain clinical importance. There were 145 deaths in the invasive-strategy group and 144 deaths in the conservative-strategy group (hazard ratio, 1.05; 95% CI, 0.83 to 1.32). CONCLUSIONS: Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).
Published: 2020
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5. Does Neutrophil Gelatinase-Asociated Lipocalin Have Prognostic Value in Patients with Stable Angina Undergoing Elective PCI? A 3-Year Follow-Up Study

Author: Hanna Bachorzewska-Gajewska, Anna Tomaszuk-Kazberuk, Iwona Jarocka, Elzbieta Mlodawska, Paulina Lopatowska, Malgorzata Zalewska-Adamiec, Slawomir Dobrzycki, Wlodzimierz J. Musial, and Jolanta Malyszko
Subjects: Percutaneous coronary intervention, Mortality, Stable angina, Neutrophil gelatinase-associated lipocalin, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923
Abstract: Background: Neutrophil gelatinase-associated lipocalin (NGAL), a widely accepted diagnostic marker of acute renal injury (AKI) may be involved in the development of atherosclerosis. Purpose: To assess the prognostic significance of serum and urinary NGAL and serum cystatin C in patients with stable angina undergoing percutaneous coronary intervention (PCI) on a 3-year follow-up. Methods: We included patients with stable angina undergoing PCI. Serum NGAL and cystatin C were evaluated before and 4h, 8h after PCI. Urinary NGAL was evaluated before and 12h and 24h after the procedure. The primary end-point was all-cause mortality on a 3-year follow-up. Results: Among 132 patients there were 63% of males (mean age 64,5±9,8 years). Mean eGFR was 86.2±28.5 ml/min. During follow-up 8% of the patients died. All-cause mortality was significantly higher in patients with increased urinary NGAL concentration 12h after PCI (p=0.04). Urinary NGAL 12h after PCI correlated with eGFR (pConclusions: Increased urinary NGAL concentration is a strong predictor of mortality in patients with stable angina who undergo PCI and may be used for the risk stratification in this population.
Published: 2013
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6. Dermoscopy of external ear melanoma (EEM)

Author: Grazyna Kaminska-Winciorek, M. Slowinska, J. Krotowski, A. Nasierowska-Guttmejer, J. Musial, and B. Cybulska-Stopa
Subjects: Dermatology, General Medicine
Published: 2022
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7. Dermoscopy of external ear melanoma (EEM)

Author: Grazyna, Kaminska-Winciorek, M, Slowinska, J, Krotowski, A, Nasierowska-Guttmejer, J, Musial, and B, Cybulska-Stopa
Abstract: External ear melanoma (EEM) belongs to extremely rare melanoma locations. So far, only single cases of EEM have been described in terms of dermoscopic presentations. This case study report presents dermoscopic patterns of EEM in six patients. The retrospective case study was based on medical documentation (epidemiological, anamnestic, clinical, videodermoscopic, and histopathologic) of consecutive patients who were diagnosed with melanoma located on the external ear between January 2013 and May 2021 in three diagnostic dermatologic centers. In four of six cases, the melanoma was placed on the helix. The histopathological diagnoses included 1/6 lentigo maligna and 5/6 invasive melanomas. The dermoscopic pattern of facial melanoma (FM) was present in 3/6 cases, 1/6 exhibited the typical superficial spreading pattern (one with nodular invasion), 1/6 the multicomponent asymmetric pattern, and 1/6 the hypomelanotic type. Five melanomas presented numerous (3-6) dermoscopic structures characteristic for each dermoscopic subtype. In conclusion, dermoscopy has proved effective for detection of both difficult and easy-to-diagnose EEM, but also in differentiating their dermoscopic subtypes.
Published: 2021

8. Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study

Author: Johan Kolmert, Cristina Gómez, David Balgoma, Marcus Sjödin, Johan Bood, Jon R. Konradsen, Magnus Ericsson, John-Olof Thörngren, Anna James, Maria Mikus, Ana R. Sousa, John H. Riley, Stewart Bates, Per S. Bakke, Ioannis Pandis, Massimo Caruso, Pascal Chanez, Stephen J. Fowler, Thomas Geiser, Peter Howarth, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Annelie Behndig, Dominick E. Shaw, Richard G. Knowles, Cécile T. J. Holweg, Åsa M. Wheelock, Barbro Dahlén, Björn Nordlund, Kjell Alving, Gunilla Hedlin, Kian Fan Chung, Ian M. Adcock, Peter J. Sterk, Ratko Djukanovic, Sven-Erik Dahlén, Craig E. Wheelock, H. Ahmed, C. Auffray, A. T. Bansal, E. H. Bel, J. Bigler, B. Billing, F. Baribaud, H. Bisgaard, M. J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, A. Chaiboonchoe, C. H. Compton, J. Corfield, D. Cunoosamy, A. D’Amico, B. De Meulder, V. J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L. J. Fleming, E. Formaggio, U. Frey, M. Gahlemann, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, P. W. Hekking, T. Higenbottam, J. M. Hohlfeld, A. J. Knox, N. Lazarinis, D. Lefaudeux, M. J. Loza, R. Lutter, A. Manta, S. Masefield, J. G. Matthews, A. Mazein, A. Meiser, R. J. M. Middelveld, M. Miralpeix, N. Mores, C. S. Murray, J. Musial, D. Myles, L. Pahus, S. Pavlidis, A. Postle, P. Powel, G. Praticò, M. PuigValls, N. Rao, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J. P. R. Schofield, W. Seibold, A. Selby, R. Sigmund, F. Singer, P. J. Skipp, M. Smicker, K. Sun, B. Thornton, M. Uddin, W. M. van Aalderen, M. van Geest, J. Vestbo, N. H. Vissing, A. H. Wagener, S. S. Wagers, Z. Weiszhart, S. J. Wilson, J. Östling, Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Male, Severe asthma, Metabolite, type 2 inflammation, Respiratory Medicine and Allergy, [SDV]Life Sciences [q-bio], Physiology, Omalizumab, Critical Care and Intensive Care Medicine, chemistry.chemical_compound, 0302 clinical medicine, 030212 general & internal medicine, Child, ComputingMilieux_MISCELLANEOUS, mass spectrometry, Lungmedicin och allergi, 2. Zero hunger, Leukotriene E4, Prostaglandin D2, Type 2 inflammation, Middle Aged, respiratory system, 3. Good health, medicine.anatomical_structure, Prednisolone, Female, lipids (amino acids, peptides, and proteins), medicine.drug, Pulmonary and Respiratory Medicine, Adult, severe asthma, Settore BIO/14 - FARMACOLOGIA, Urinary system, U-BIOPRED, Asthma and Allergy, 03 medical and health sciences, Correspondence, medicine, Humans, Asthma, Inflammation, Mass spectrometry, business.industry, Original Articles, Eosinophil, medicine.disease, respiratory tract diseases, urinary eicosanoid metabolites, 030228 respiratory system, chemistry, Diabetes Mellitus, Type 2, Exhaled nitric oxide, Prostaglandins, Urinary eicosanoid metabolites, business, Biomarkers
Abstract: Rationale: New approaches are needed to guide personalized treatment of asthma. Objectives: To test if urinary eicosanoid metabolites can direct asthma phenotyping. Methods: Urinary metabolites of prostaglandins (PGs), cysteinyl leukotrienes (CysLTs), and isoprostanes were quantified in the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) study including 86 adults with mild-to-moderate asthma (MMA), 411 with severe asthma (SA), and 100 healthy control participants. Validation was performed internally in 302 participants with SA followed up after 12-18 months and externally in 95 adolescents with asthma. Measurement and Main Results: Metabolite concentrations in healthy control participants were unrelated to age, body mass index, and sex, except for the PGE 2 pathway. Eicosanoid concentrations were generally greater in participants with MMA relative to healthy control participants, with further elevations in participants with SA. However, PGE 2 metabolite concentrations were either the same or lower in male nonsmokers with asthma than in healthy control participants. Metabolite concentrations were unchanged in those with asthma who adhered to oral corticosteroid treatment as documented by urinary prednisolone detection, whereas those with SA treated with omalizumab had lower concentrations of LTE 4 and the PGD 2 metabolite 2,3-dinor-11β-PGF 2α. High concentrations of LTE 4 and PGD 2 metabolites were associated with lower lung function and increased amounts of exhaled nitric oxide and eosinophil markers in blood, sputum, and urine in U-BIOPRED participants and in adolescents with asthma. These type 2 (T2) asthma associations were reproduced in the follow-up visit of the U-BIOPRED study and were found to be as sensitive to detect T2 inflammation as the established biomarkers. Conclusions: Monitoring of urinary eicosanoids can identify T2 asthma and introduces a new noninvasive approach for molecular phenotyping of adult and adolescent asthma.Clinical trial registered with www.clinicaltrials.gov (NCT01976767).
Published: 2020
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9. Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation

Author: Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C.K. Lau, Susan J. Wilson, Jonathan A. Ward, Anoop Chauhan, Ana R. Sousa, Bertrand De Meulder, Matthew J. Loza, Frédéric Baribaud, Peter J. Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M. Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E. Shaw, Norbert Krug, Jens M. Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S.C. Hinks, Peter H. Howarth, Outi Vaarala, Marleen van Geest, Henric Olsson, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, F.K. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, V. Goss, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, A. Manta, J.G. Matthews, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, A. Postle, P. Powel, G. Praticò, N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, J.P.R. Schofield, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Publica, HUS Children and Adolescents, Commission of the European Communities, Pulmonology, AII - Inflammatory diseases, and Paediatric Pulmonology
Subjects: Male, 0301 basic medicine, MMP3, Allergy, MATRIX METALLOPROTEINASES, Respiratory Medicine and Allergy, Eepithelial integrity, airway inflammation, Systemic inflammation, DISEASE, Cohort Studies, transcriptomics, 0302 clinical medicine, Receptors, Immunology and Allergy, Lung, Macrophage inflammatory protein, Cells, Cultured, Lungmedicin och allergi, remodeling, Toll-like receptor, Cultured, CHITINASE-LIKE PROTEIN, 3. Good health, Phenotype, TARGET, medicine.anatomical_structure, 1107 Immunology, Airway Remodeling, eosinophils, medicine.symptom, Life Sciences & Biomedicine, hierarchical clustering, Signal Transduction, Adult, Settore BIO/14 - FARMACOLOGIA, Immunology, lung epithelium, 03 medical and health sciences, HYPERRESPONSIVENESS, Respiratory Hypersensitivity, medicine, Humans, Hierarchical Clustering, Inflammation, Science & Technology, Innate immune system, exacerbation frequency, Interleukin-6, business.industry, Sputum, Epithelial Cells, Gene signature, Receptors, Interleukin-6, DYSFUNCTION, Asthma, respiratory tract diseases, Eosinophils, Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes study group, Cross-Sectional Studies, SEVERITY, 030104 developmental biology, Gene Expression Regulation, 030228 respiratory system, INTERLEUKIN-6 RECEPTOR, BARRIER FUNCTION, 3121 General medicine, internal medicine and other clinical medicine, CELLS, epithelial integrity, IL-6 signaling, Exacerbation frequency, Transcriptome, business, Biomarkers
Abstract: BackgroundAlthough several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) to asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthmatic patients is unclear.ObjectiveWe sought to explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthmatic patients.MethodsAn IL-6TS gene signature obtained from air-liquid interface cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R was used to stratify lung epithelial transcriptomic data (Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes [U-BIOPRED] cohorts) by means of hierarchical clustering. IL-6TS–specific protein markers were used to stratify sputum biomarker data (Wessex cohort). Molecular phenotyping was based on transcriptional profiling of epithelial brushings, pathway analysis, and immunohistochemical analysis of bronchial biopsy specimens.ResultsActivation of IL-6TS in air-liquid interface cultures reduced epithelial integrity and induced a specific gene signature enriched in genes associated with airway remodeling. The IL-6TS signature identified a subset of patients with IL-6TS–high asthma with increased epithelial expression of IL-6TS–inducible genes in the absence of systemic inflammation. The IL-6TS–high subset had an overrepresentation of frequent exacerbators, blood eosinophilia, and submucosal infiltration of T cells and macrophages. In bronchial brushings Toll-like receptor pathway genes were upregulated, whereas expression of cell junction genes was reduced. Sputum sIL-6R and IL-6 levels correlated with sputum markers of remodeling and innate immune activation, in particular YKL-40, matrix metalloproteinase 3, macrophage inflammatory protein 1β, IL-8, and IL-1β.ConclusionsLocal lung epithelial IL-6TS activation in the absence of type 2 airway inflammation defines a novel subset of asthmatic patients and might drive airway inflammation and epithelial dysfunction in these patients.
Published: 2019
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10. Validation v2 (D2.8 e D2.8A)

Author: A. Balenzano (1), F. Mattia (1), G. Satalino (1), F. Lovergine (1), D. Palmisano (1), J. Peng (2), P. Marzahn (2), O. Cartus (3), U. Wegmuller (3), J. Musial (4), and K. Dabrowska-Zielinska (4)
Subjects: validation, sentinel-1, high resolution surface soil moisture product
Abstract: The objective of the Validation deliverable (D2.8) is to present the validation of the Sentinel-1 (S-1) Surface Soil Moisture (SSM) retrieval algorithms described in the ATBD (D2.1&D2.1A) and implemented in the Prototype Software (D2.7). The Committee on Earth Observation Satellites (CEOS) Working Group on Calibration and Validation (WGCV) (https://lpvs.gsfc.nasa.gov/) has established standards that are currently being used for satellite SSM product validation (e.g. SMAP, SMOS, ESA CCI Cal/Val Plan). The methodologies adopted to estimate the uncertainty of the SSM products include the direct comparison of retrieved SSM values with independent measurements from in situ networks or satellite products. In this study, both approaches have been implemented and hereafter labelled as validation at local and regional scales (see the Validation Plan, D1.3).
Published: 2019

11. IL-17-high asthma with features of a psoriasis immunophenotype

Author: Jörgen Östling, Marleen van Geest, James P.R. Schofield, Zala Jevnikar, Susan Wilson, Jonathan Ward, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Sven-Erik Dahlen, Stephen J. Fowler, Ildikó Horváth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Ana R. Sousa, Yike Guo, Ian M. Adcock, Peter Howarth, Kian Fan Chung, Jeanette Bigler, Peter J. Sterk, Paul J. Skipp, Ratko Djukanović, Outi Vaarala, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, K.F. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, Y. Guo, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, A.J. Knox, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, P. Montuschi, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powell, G. Praticò, M. Puig N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Antonios Aliprantis, David Allen, Kjell Alving, P. Badorrek, David Balgoma, S. Ballereau, Clair Barber, Manohara Kanangana Batuwitage, A. Bautmans, A. Bedding, A.F. Behndig, Jorge Beleta, A. Berglind, A. Berton, Grazyna Bochenek, Armin Braun, D. Campagna, Leon Carayannopoulos, C. Casaulta, Romanas Chaleckis, B. Dahlén, imothy Davison, Jorge De Alba, Inge De Lepeleire, Tamara Dekker, Ingrid Delin, P. Dennison, Annemiek Dijkhuis, Paul Dodson, Aleksandra Draper, K. Dyson, Jessica Edwards, L. El Hadjam, Rosalia Emma, Magnus Ericsson, C. Faulenbach, Breda Flood, G. Galffy, Hector Gallart, D. Garissi, J. Gent, M. Gerhardsson de Verdier, D. Gibeon, Cristina Gomez, Kerry Gove, Neil Gozzard, E. Guillmant-Farry, E. Henriksson, Lorraine Hewitt, U. Hoda, Richard Hu, Sile Hu, X. Hu, E. Jeyasingham, K. Johnson, N. Jullian, Juliette Kamphuis, Erika J. Kennington, Dyson Kerry, G. Kerry, M. Klüglich, Hugo Knobel, Johan Kolmert, J.R. Konradsen, Maxim Kots, Kosmas Kretsos, L. Krueger, Scott Kuo, Maciej Kupczyk, Bart Lambrecht, A.-S. Lantz, Christopher Larminie, L.X. Larsson, P. Latzin, N. Lazarinis, N. Lemonnier, Saeeda Lone-Latif, L.A. Lowe, Alexander Manta, Lisa Marouzet, Jane Martin, Caroline Mathon, L. McEvoy, Sally Meah, A. Menzies-Gow, Leanne Metcalf, Maria Mikus, Philip Monk, Shama Naz, K. Nething, Ben Nicholas, U. Nihlén, Peter Nilsson, R. Niven, B. Nordlund, S. Nsubuga, Antonio Pacino, Susanna Palkonen, J. Pellet, Giorgio Pennazza, Anne Petrén, Sandy Pink, C. Pison, Anthony Postle, Malayka Rahman-Amin, Lara Ravanetti, Emma Ray, Stacey Reinke, Leanne Reynolds, K. Riemann, Martine Robberechts, J.P. Rocha, C. Rossios, Kirsty Russell, Michael Rutgers, G. Santini, Marco Santoninco, M. Saqi, Corinna Schoelch, S. Scott, N. Sehgal, Marcus Sjödin, Barbara Smids, Caroline Smith, Jessica Smith, Katherine M. Smith, P. Söderman, A. Sogbessan, F. Spycher, Doroteya Staykova, S. Stephan, J. Stokholm, K. Strandberg, M. Sunther, M. Szentkereszty, L. Tamasi, K. Tariq, John-Olof Thörngren, Jonathan Thorsen, S. Valente, Marianne van de Pol, C.M. van Drunen, Jonathan Van Eyll, Jenny Versnel, Anton Vink, C. von Garnier, A. Vyas, Frans Wald, Samantha Walker, Kristiane Wetzel, Coen Wiegman, Siân Williams, Xian Yang, Elizabeth Yeyasingham, W. Yu Amgen, W. Zetterquist, Z. Zolkipli, A.H. Zwinderman, Publica, Pediatric surgery, Amsterdam Reproduction & Development (AR&D), Pulmonology, AII - Inflammatory diseases, Experimental Immunology, Ear, Nose and Throat, Epidemiology and Data Science, APH - Methodology, and Commission of the European Communities
Subjects: 0301 basic medicine, Male, URINARY-EXCRETION, Allergy, Neutrophils, Inflammatory bowel disease, Cohort Studies, DOUBLE-BLIND, 0302 clinical medicine, Immunology and Allergy, POPULATION, Interleukin-13, Interleukin-17, psoriasis, BRODALUMAB, Up-Regulation, IL-17, Phenotype, 1107 Immunology, Biomarker (medicine), Female, Interleukin 17, medicine.symptom, Life Sciences & Biomedicine, ENDOTYPES, Signal Transduction, EXPRESSION, Adult, Settore BIO/14 - FARMACOLOGIA, Immunology, PHENOTYPES, Bronchi, 03 medical and health sciences, INFLAMMATION, Psoriasis, medicine, Humans, Interleukin 8, Asthma, U-BIOPRED Study Group, Science & Technology, business.industry, Gene Expression Profiling, biomarkers, Epithelial Cells, asthma, bronchial brushings, medicine.disease, bronchial biopsies, Neutrophilia, 030104 developmental biology, 030228 respiratory system, EXACERBATION, CELLS, Sputum, business, Transcriptome, Biomarkers
Abstract: Background The role of IL-17 immunity is well established in patients with inflammatory diseases, such as psoriasis and inflammatory bowel disease, but not in asthmatic patients, in whom further study is required. Objective We sought to undertake a deep phenotyping study of asthmatic patients with upregulated IL-17 immunity. Methods Whole-genome transcriptomic analysis was performed by using epithelial brushings, bronchial biopsy specimens (91 asthmatic patients and 46 healthy control subjects), and whole blood samples (n = 498) from the Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) cohort. Gene signatures induced in vitro by IL-17 and IL-13 in bronchial epithelial cells were used to identify patients with IL-17–high and IL-13–high asthma phenotypes. Results Twenty-two of 91 patients were identified with IL-17, and 9 patients were identified with IL-13 gene signatures. The patients with IL-17–high asthma were characterized by risk of frequent exacerbations, airway (sputum and mucosal) neutrophilia, decreased lung microbiota diversity, and urinary biomarker evidence of activation of the thromboxane B2 pathway. In pathway analysis the differentially expressed genes in patients with IL-17-high asthma were shared with those reported as altered in psoriasis lesions and included genes regulating epithelial barrier function and defense mechanisms, such as IL1B, IL6, IL8, and β-defensin. Conclusion The IL-17–high asthma phenotype, characterized by bronchial epithelial dysfunction and upregulated antimicrobial and inflammatory response, resembles the immunophenotype of psoriasis, including activation of the thromboxane B2 pathway, which should be considered a biomarker for this phenotype in further studies, including clinical trials targeting IL-17.
Published: 2019
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12. Future S-1 User Requirements (D3.1A)

Author: U. Wegmuller (1), O. Cartus (1), M. Santoro (1), F. Mattia (2), G. Satalino (2), A. Balenzano (2), F. Lovergine (2), D. Palmisano (2), J. Peng (3), P. Marzahn (3), J. Musial (4), and K. Dabrowska-Zielinska (4)
Subjects: Next-generation Sentinel-1, User Requirements
Abstract: With a view to the analysis of surface soil moisture (SSM) application and user and products requirements carried out in D1.2 and to the relationship between SAR observations and SSM retrieval accuracy addressed in the algorithm description (D2.1) and validation (D2.8), the objective of the Future S-1 User Requirements document is to formulate recommendations about mission design parameters of the next generation (NG) S-1 system that may support the take-off of operational SSM products.
Published: 2019

13. Scientific Roadmap (D3.1)

Author: J. Peng (1), P. Marzahn (1), F. Mattia (2), G. Satalino (2), F. Lovergine (2), A. Balenzano (2), U. Wegmuller (3), O. Cartus (3), M. Santoro (3), J. Musial (4), and K. Dabrowska-Zielinska (4)
Subjects: Scientific Roadmap, research priorities for future S-1 data, Sentinel-1, surface soil moisture
Abstract: The availability of dense time series of C-band SAR data acquired by the Sentinel-1 system enables the use of new and more robust approaches for surface soil moisture (SSM) retrieval from SAR data. This has been demonstrated in the validation study D2.8, where maps at ~1 km resolution have been assessed. These maps may have a large scientific and operational relevance for a number of applications, including numerical weather prediction, watershed management, runoff prediction, estimation of evapotranspiration, flood forecasting etc., as reported in D1.1. The objective of this deliverable is to draw up a Scientific Roadmap identifying research priorities for future S-1 data exploitation for SSM uptake of operational service. Challenge areas and open issues are also underlined.
Published: 2019

14. Pathway discovery using transcriptomic profiles in adult-onset severe asthma

Author: Pieter-Paul Hekking, Matt J. Loza, Stelios Pavlidis, Bertrand de Meulder, Diane Lefaudeux, Fred Baribaud, Charles Auffray, Ariane H. Wagener, Paul Brinkman, Rene Lutter, Aruna T. Bansal, Ana R. Sousa, Steve A. Bates, Yannis Pandis, Louise J. Fleming, Dominique E. Shaw, Stephen J. Fowler, Y. Guo, Andrea Meiser, Kai Sun, Julie Corfield, Peter H. Howarth, Elisabeth H. Bel, Ian M. Adcock, Kian Fan Chung, Ratko Djukanovic, Peter J. Sterk, I.M. Adcock, H. Ahmed, C. Auffray, P. Bakke, A.T. Bansal, F. Baribaud, S. Bates, E.H. Bel, J. Bigler, H. Bisgaard, M.J. Boedigheimer, K. Bønnelykke, J. Brandsma, P. Brinkman, E. Bucchioni, D. Burg, A. Bush, M. Caruso, A. Chaiboonchoe, P. Chanez, F.K. Chung, C.H. Compton, J. Corfield, A. D'Amico, S.E. Dahlen, B. De Meulder, R. Djukanovic, V.J. Erpenbeck, D. Erzen, K. Fichtner, N. Fitch, L.J. Fleming, E. Formaggio, S.J. Fowler, U. Frey, M. Gahlemann, T. Geiser, S. Hashimoto, J. Haughney, G. Hedlin, P.W. Hekking, T. Higenbottam, J.M. Hohlfeld, C. Holweg, I. Horváth, P. Howarth, A.J. James, R. Knowles, N. Krug, D. Lefaudeux, M.J. Loza, R. Lutter, A. Manta, S. Masefield, J.G. Matthews, A. Mazein, A. Meiser, R.J.M. Middelveld, M. Miralpeix, N. Mores, C.S. Murray, J. Musial, D. Myles, L. Pahus, I. Pandis, S. Pavlidis, P. Powel, G. Praticò, M Puig Valls, N. Rao, J. Riley, A. Roberts, G. Roberts, A. Rowe, T. Sandström, W. Seibold, A. Selby, D.E. Shaw, R. Sigmund, F. Singer, P.J. Skipp, A.R. Sousa, P.J. Sterk, K. Sun, B. Thornton, W.M. van Aalderen, M. van Geest, J. Vestbo, N.H. Vissing, A.H. Wagener, S.S. Wagers, Z. Weiszhart, C.E. Wheelock, S.J. Wilson, Publica, Pulmonology, AII - Inflammatory diseases, Graduate School, AII - Amsterdam institute for Infection and Immunity, ARD - Amsterdam Reproduction and Development, Medical Research Council (MRC), and Pediatric surgery
Subjects: 0301 basic medicine, Male, Allergy, Severe asthma, ILC3, mast cells, Disease, Eosinophil, Severity of Illness Index, transcriptomics, 0302 clinical medicine, Eosinophilic, Immunology and Allergy, Medicine, Age of Onset, Oligonucleotide Array Sequence Analysis, mechanisms, Innate lymphoid cell, Adult-onset asthma, eosinophils, gene set variation analysis, phenotyping, severe asthma, Middle Aged, Phenotype, Asthma Control Questionnaire, 1107 Immunology, Female, medicine.symptom, Adult, Genetic Markers, Immunology, mechanism, macromolecular substances, Lung injury, 03 medical and health sciences, Humans, adult-onset asthma, Asthma, U-BIOPRED Study Group, business.industry, Gene Expression Profiling, medicine.disease, respiratory tract diseases, 030104 developmental biology, Cross-Sectional Studies, 030228 respiratory system, Sputum, business, Transcriptome, mast cell
Abstract: Background: Adult-onset severe asthma is characterized by highly symptomatic disease despite high-intensity asthma treatments. Understanding of the underlying pathways of this heterogeneous disease is needed for the development of targeted treatments. Gene set variation analysis is a statistical technique used to identify gene profiles in heterogeneous samples. Objective: We sought to identify gene profiles associated with adult-onset severe asthma. Methods: This was a cross-sectional, observational study in which adult patients with adult-onset of asthma (defined as starting at age ≥18 years) as compared with childhood-onset severe asthma (
Published: 2018
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15. Sentinel-1 high-resolution soil moisture product and validation

Author: F. Mattia (1), A. Balenzano (1), G. Satalino (1), F. Lovergine (1), J. Peng (2&3), U. Wegmuller (4), M. Santoro (4), O. Cartus (4), K. Dabrowska-Zielinska (5), J. Musial (5), and M.W. J. Davidson (6)
Subjects: validation, Sentinel-1, soil moisture
Abstract: In this work, the objective is to discuss a validation strategy for Sentinel-1 (S-1) Surface Soil Moisture (SSM) Product at 1km resolution
Published: 2018

16. Database Version 2

Author: F. Mattia, G. Satalino, A. Balenzano, F. Lovergine (1) U. Wegmüller, M. Santoro, O. Cartus (2) A. Loew, T. Weiss J. Peng (3) J. Musial, and K. Dabrowska-Zielinska (4)
Subjects: Database, Low Resolution Surface Soil Moisture Product Collection, Sentinel-1 pre-processing
Abstract: In Exploit-S-1 project, the objective of the data base is to centralize all the pre-processed EO, the output of the retrieval algorithms and ground data. The data base has been designed in order to serve, from the one side, the algorithm validation and, from the other, the requirements of the webgis service. In this document, the data base structure is illustrated and examples of SQL queries and outputs are provided. Furthermore, the optimal GAMMA pre-processing of Sentinel-1 time series for surface parameter retrieval is detailed. Finally, the characteristics of a global data base of SSM maps derived from NASA/SMAP, ESA/SMOS and EUMETSAT/ASCAT that has been compiled to support the regional scale validation are described.
Published: 2018

17. High resolution Soil moisture content from Sentinel-1 data

Author: F. Mattia(1), A. Balenzano(1), G. Satalino(1), F. Lovergine(1), A. Loew(2), J. Peng(2&3), U. Wegmuller(4), M. Santoro(4), O. Cartus(4), K. Dabrowska-Zielinska(5), J. Musial(5), and M. W. J. Davidson(6)
Subjects: validation, sentinel1-1, soil moisture
Published: 2017

18. CHA

Author: Elzbieta, Mlodawska, Anna, Tomaszuk-Kazberuk, Paulina, Lopatowska, Marcin, Kaminski, and Wlodzimierz J, Musial
Subjects: Male, Electric Countershock, Reproducibility of Results, Middle Aged, Prognosis, Risk Assessment, Stroke, Predictive Value of Tests, Risk Factors, Thromboembolism, Atrial Fibrillation, Quality of Life, Health Status Indicators, Humans, Female, Anti-Arrhythmia Agents, Aged
Abstract: Atrial fibrillation (AF) is the most common arrhythmia occurring in 2% of the population. It is known that AF increases morbidity and limits quality of life. The CHATo assess the value of CHAWe analysed 258 consecutive patients with persistent AF who underwent electrical cardioversion between January 2012 and April 2016 in a Cardiology University Centre in Poland.Out of 3500 hospitalised patients with AF, 258 (mean age 64 ± 11 years, 64% men) underwent electrical cardioversion. The CHAThe CHA
Published: 2016

19. Poster session III * Friday 10 December 2010, 08:30-12:30

Author: D. Guldbrand, O. Goetzsche, B. Eika, N. Watanabe, M. Taniguchi, T. Akagi, N. Koide, S. Sano, B. Orbovic, B. Obrenovic-Kircanski, S. Ristic, L. J. Soskic, F. Alhabshan, A. Jijeh, H. Abo Remsh, A. Alkhaldi, H. K. Najm, Z. Gasior, M. Skowerski, A. Kulach, L. Szymanski, M. Sosnowski, M. Wang, C. W. Siu, K. Lee, W. S. Yue, G. H. Yan, S. Lee, C. P. Lau, H. F. Tse, K. O'connor, M. Rosca, J. Magne, G. Romano, M. Moonen, L. A. Pierard, P. Lancellotti, M. Floria, L. De Roy, D. Blommaert, J. Jamart, F. Dormal, M. Lacrosse, C. Arsenescu Georgescu, V. Mizariene, S. Bucyte, A. Bertasiute, E. Pociute, D. Zaliaduonyte-Peksiene, K. Baronaite-Dudoniene, R. Sileikiene, J. Vaskelyte, R. Jurkevicius, M. Dencker, O. Thorsson, M. K. Karlsson, C. Linden, P. Wollmer, L. B. Andersen, O. Catalano, M. R. Perotti, E. Colombo, M. De Giorgi, M. Cattaneo, F. Cobelli, S. G. Priori, C. Ober, I. A. Iancu Adrian, P. A. Andreea Parv, C. H. Cadis Horatiu, O. M. Ober Mihai, M. Chmielecki, M. Fijalkowski, R. Galaska, W. Dubaniewicz, L. Lewicki, R. Targonski, D. Ciecwierz, W. Puchalski, A. Koprowski, A. Rynkiewicz, K. Hristova, A. La Gerche, T. Z. Katova, V. Kostova, Y. Simova, A. Kempny, G. P. Diller, S. Orwat, G. Kaleschke, G. Kerckhoff, R. Schmidt, R. M. Radke, H. Baumgartner, K. Smarz, B. Zaborska, T. Jaxa-Chamiec, P. Maciejewski, A. Budaj, A. Kiotsekoglou, S. C. Govind, V. Gadiyaram, J. C. Moggridge, M. Govindan, A. S. Gopal, S. S. Ramesh, L. A. Brodin, S. K. Saha, I. S. Ramzy, P. Lindqvist, Y. Y. Lam, A. M. Duncan, M. Y. Henein, I. S. Craciunescu, M. Serban, M. Iancu, C. Revnic, B. A. Popescu, D. Alexandru, D. Rogoz, V. Uscatescu, C. Ginghina, G. Careri, A. Di Monaco, R. Nerla, P. Tarzia, P. Lamendola, A. Sestito, G. A. Lanza, F. Crea, F. Giannini, B. Pinamonti, S. Santangelo, A. Perkan, G. Vitrella, S. Rakar, M. Merlo, E. Della Grazia, A. Salvi, G. Sinagra, P. Scislo, J. Kochanowski, R. Piatkowski, M. Roik, M. Postula, G. Opolski, J. Castillo, N. Herszkowicz, C. Ferreira, M. T. Lonnebakken, E. M. Staal, J. E. Nordrehaug, E. Gerdts, M. Przewlocka-Kosmala, A. Orda, B. Karolko, G. Bajraktari, U. Gustafsson, A. Holmgren, S. Frattini, P. Faggiano, V. Zilioli, E. Locantore, S. Longhi, F. Bellandi, G. Faden, M. Triggiani, L. Dei Cas, S. M. Seo, H. O. Jung, S. H. An, S. Y. Jung, C. S. Park, H. K. Jeon, H. J. Youn, W. B. Chung, J. H. Kim, J. S. Uhm, W. Mampuya, M. C. Brochu, D. H. Do, B. Essadiqi, P. Farand, S. Lepage, M. J. Daly, M. Monaghan, A. Hamilton, C. Lockhart, V. Kodoth, C. Maguire, A. Morton, G. Manoharan, M. S. Spence, W. Streb, K. Mitrega, J. Nowak, A. Duszanska, M. Szulik, M. Kalinowski, T. Kukulski, Z. Kalarus, F. E. Calvo Iglesias, I. Solla-Ruiz, I. Villanueva-Benito, E. Paredes-Galan, M. Bravo-Amaro, A. Iniguez-Romo, O. Yildirimturk, F. F. Helvacioglu, Y. Tayyareci, S. Yurdakul, I. C. Demiroglu, S. Aytekin, R. Enache, R. Piazza, D. Muraru, A. Roman-Pognuz, A. Calin, E. Leiballi, F. Antonini-Canterin, G. L. Nicolosi, C. Ridard, A. Bellouin, C. Thebault, M. Laurent, E. Donal, A. Sutandar, B. B. Siswanto, I. Irmalita, G. Harimurti, A. Saxena, S. Ramakrishnan, A. Roy, A. Krishnan, P. Misra, B. Bhargava, P. A. Poole-Wilson, B. B. Loegstrup, H. R. Andersen, S. H. Poulsen, K. E. Klaaborg, H. E. Egeblad, X. Gu, X. Y. Gu, Y. H. He, Z. A. Li, J. C. Han, J. Chen, N. Mansencal, E. Mitry, P. Rougier, O. Dubourg, H. Villarraga, K. Adjei-Twum, T. K. M. Cudjoe, A. Clavell, R. M. Schears, F. Cabrera Bueno, M. J. Molina Mora, J. Fernandez Pastor, A. Linde Estrella, J. L. Pena Hernandez, G. Isasti Aizpurua, F. Carrasco Chinchilla, A. Barrera Cordero, F. J. Alzueta Rodriguez, E. De Teresa Galvan, G. C. Gaetano Contegiacomo, F. P. Francesco Pollice, P. P. Paolo Pollice, M. C. Kontos, D. H. Shin, S. Y. Yoo, C. K. Lee, J. K. Jang, S. I. Jung, S. I. Song, S. I. Seo, S. S. Cheong, J. Peteiro, A. Perez-Perez, A. Bouzas-Mosquera, M. Pineiro, P. Pazos, R. Campo, A. Castro-Beiras, N. Gaibazzi, F. Rigo, D. Sartorio, C. Reverberi, S. Sitia, L. Tomasoni, L. Gianturco, L. Ghio, D. Stella, P. Greco, V. De Gennaro Colonna, M. Turiel, S. Cicala, V. Magagnin, E. Caiani, S. Kyrzopoulos, D. Tsiapras, G. Domproglou, E. Avramidou, V. Voudris, K. Wierzbowska-Drabik, P. Lipiec, L. Chrzanowski, N. Roszczyk, K. Kupczynska, J. D. Kasprzak, V. Sachpekidis, A. Bhan, S. Gianstefani, J. Reiken, M. Paul, P. Pearson, D. Harries, M. J. Monaghan, K. Dale, A. Stoylen, V. Kodali, R. Toole, P. Raju, R. A. Mcintosh, J. Silberbauer, O. Baumann, N. R. Patel, N. Sulke, U. Trivedi, J. Hyde, G. Venn, G. Lloyd, P. Wejner-Mik, K. Wierzbowska, J. A. Lowenstein, C. Caniggia, A. Garcia, M. Amor, N. Casso, D. Lowenstein Haber, C. Porley, G. Zambrana, V. Daru, M. Deljanin Ilic, S. Ilic, D. Kalimanovska Ostric, V. Stoickov, M. Zdravkovic, I. Paraskevaidis, I. Ikonomidis, J. Parissis, C. Papadopoulos, V. Stasinos, V. Bistola, M. Anastasiou-Nana, M. Gudin Uriel, J. R. Balaguer Malfagon, J. L. Perez Bosca, F. Ridocci Soriano, N. Martinez Alzamora, R. Paya Serrano, Q. Ciampi, L. Pratali, M. Della Porta, B. Petruzziello, B. Villari, E. Picano, R. Sicari, A. Rosner, D. Avenarius, S. Malm, A. Iqbal, A. Baltabaeva, G. R. Sutherland, B. Bijnens, T. Myrmel, M. Andersen, F. Gustafsson, N. H. Secher, P. Brassard, A. S. Jensen, C. Hassager, P. L. Madsen, J. E. Moller, M. Coutu, D. Greentree, D. Normandin, H. Brun, A. Dipchand, L. Koopman, C. T. Fackoury, S. Truong, C. Manlhiot, L. Mertens, M. Baroni, M. Mariani, H. K. Chabane, S. Berti, A. Ripoli, S. Storti, M. Glauber, P. A. Scopelliti, G. B. Antongiovanni, D. Personeni, A. Saino, M. Tespili, P. Jung, M. Mueller, F. Jander, H. Y. Sohn, J. Rieber, P. Schneider, V. Klauss, E. Agricola, M. Slavich, S. Stella, M. Ancona, M. Oppizzi, L. Bertoglio, G. Melissano, A. Margonato, R. Chiesa, L. Cejudo Diaz Del Campo, D. Mesa Rubio, M. Ruiz Ortiz, M. Delgado Ortega, E. Villanueva Fernandez, J. Lopez Aguilera, F. Toledano Delgado, M. Pan Alvarez-Ossorio, J. Suarez De Lezo Cruz Conde, M. Lafuente, T. Butz, A. Meissner, C. N. Lang, M. W. Prull, G. Plehn, H. J. Trappe, S. V. Nair, L. Lee, I. Mcleod, G. Whyte, J. Shrimpton, D. Hildick Smith, P. R. James, J. Slikkerveer, Y. E. A. Appelman, G. Veen, T. R. Porter, O. Kamp, P. Colonna, F. J. Ten Cate, D. Bokor, A. Daponte, M. Cocciolo, M. Bona, S. Sacchi, H. Becher, S. C. Chai, P. J. Tan, Y. S. Goh, S. H. Ong, J. Chow, L. L. Lee, P. P. Goh, K. L. Tong, R. Kakihara, C. Naruse, H. Hironaka, T. Tsuzuku, K. Ozawa, A. Tomaszuk-Kazberuk, B. Sobkowicz, J. Malyszko, J. S. Malyszko, R. Sawicki, T. Hirnle, S. Dobrzycki, M. Mysliwiec, W. J. Musial, W. Mathias, I. Kowatsch, A. L. R. Saroute, A. F. F. Osorio, J. C. N. Sbano, J. A. F. Ramires, J. M. Tsutsui, K. Sakata, H. Ito, K. Ishii, T. Sakuma, K. Iwakura, H. Yoshino, J. Yoshikawa, K. Shahgaldi, A. Lopez, B. Fernstrom, A. Sahlen, R. Winter, S. Kovalova, J. Necas, B. H. Amundsen, R. Jasaityte, G. Kiss, D. Barbosa, J. D'hooge, H. Torp, C. A. Szmigielski, J. D. Newton, K. Rajpoot, J. A. Noble, R. Kerber, L. P. Koopman, C. Slorach, N. Chahal, W. Hui, T. Sarkola, T. J. Bradley, E. T. Jaeggi, B. W. Mccrindle, A. Staron, M. Jasinski, S. Wos, P. Sengupta, D. Hayat, M. Kloeckner, J. Nahum, C. Dussault, J. L. Dubois Rande, P. Gueret, P. Lim, G. J. King, A. Brown, E. Ho, I. Amuntaser, K. Bennet, N. Mc Elhome, R. T. Murphy, R. M. Cooper, J. D. Somauroo, R. E. Shave, K. L. Williams, J. Forster, C. George, T. Bett, K. P. George, A. D'andrea, L. Riegler, R. Cocchia, E. Golia, R. Gravino, G. Salerno, R. Citro, P. I. O. Caso, E. Bossone, R. Calabro', F. Crispi, F. Figueras, J. Bartrons, E. Eixarch, F. Le Noble, A. Ahmed, E. Gratacos, Q. Shang, W. K. Yip, L. S. Tam, Q. Zhang, C. M. Li, T. Wang, C. Y. Ma, K. M. Li, C. M. Yu, T. Dahlslett, I. Helland, T. Edvardsen, H. Skulstad, L. S. Magda, M. Florescu, A. Ciobanu, R. Dulgheru, R. Mincu, D. Vinereanu, M. Luckie, S. Chacko, S. Nair, M. Mamas, R. S. Khattar, M. El-Omar, A. Kuch-Wocial, P. Pruszczyk, M. Szulc, G. Styczynski, M. Sinski, A. Kaczynska, Z. Vela, E. Haliti, V. Hyseni, R. Olloni, N. Rexhepaj, S. Elezi, J. J. Onaindia, O. Quintana, A. Cacicedo, S. Velasco, J. J. Alarcon, M. Morillas, J. R. Rumoroso, J. Zumalde, I. Lekuona, E. Laraudogoitia Zaldumbide, A. Poniku, A. Ahmeti, R. F. Duncan, J. M. Mccomb, J. Pemberton, S. W. Lord, D. Leong, C. Plummer, G. Macgowan, N. Grubb, M. Leung, A. Kenny, C. Prinz, J. U. Voigt, A. Zaidi, M. Heatley, S. Z. Abildstrom, A. Hvelplund, J. Berning, S. Govind, L. Brodin, A. Gopal, B. Castaldi, G. Di Salvo, G. Santoro, G. Gaio, M. T. Palladino, C. Iacono, G. Pacileo, M. G. Russo, R. Calabro, Y. S. Wang, L. L. Dong, X. H. Shu, C. Z. Pan, D. X. Zhou, T. Sen, O. Tufekcioglu, M. Ozdemir, A. Tuncez, B. Uygur, Z. Golbasi, H. Kisacik, L. Delfino, F. D. De Leo, L. C. Chiappa, B. Abdel Ghani, R. Schiavina, P. Salvade, A. Morganti, F. Bedogni, P. Mahia, L. Gutierrez, V. Pineda, B. Garcia, I. Otaegui, J. F. Rodriguez, M. T. Gonzalez, M. Descalzo, A. Evangelista, D. Garcia-Dorado, H. A. C. M. Bruin De- Bon, R. B. A. Van Den Brink, S. Surie, P. Bresser, J. Vleugels, H. M. Eckmann, D. A. Samson, B. J. Bouma, C. Dedobbeleer, M. Antoine, M. Remmelink, P. Unger, B. Roosens, I. Hmila, S. Hernot, S. Droogmans, G. Van Camp, T. Lahoutte, S. Muyldermans, B. Cosyns, G. Feltes, V. Serra, O. Azevedo, J. Barbado, J. Herrera, A. Rivera, J. Paniagua, V. Valverde, J. Torras, G. Arriba, T. Christodoulides, M. Ioannides, K. Simamonian, K. Yiangou, M. Myrianthefs, E. Nicolaides, M. Pandolfo, S. A. Kleijn, M. F. A. A. Aly, C. B. Terwee, A. C. Van Rossum, V. Delgado, M. Shanks, H. M. Siebelink, A. Sieders, H. Lamb, N. Ajmone Marsan, J. Westenberg, A. De Roos, J. D. Schuijf, J. J. Bax, A. M. Anwar, Y. Nosir, H. Chamsi-Pasha, H. D. Tschernich, J. Seeburger, M. Borger, C. Mukherjee, F. W. Mohr, J. Ender, K. Obase, H. Okura, R. Yamada, Y. Miyamoto, K. Saito, K. Imai, A. Hayashida, and K. Yoshida
Subjects: medicine.medical_specialty, business.industry, Physical therapy, Medicine, Radiology, Nuclear Medicine and imaging, General Medicine, Session (computer science), Cardiology and Cardiovascular Medicine, business
Published: 2010
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20. Predictors of Long-Term Mortality in Patients Hospitalized in an Intensive Cardiac Care Unit

Author: Ewa, Uscinska, Bożena, Sobkowicz, Anna, Lisowska, Robert, Sawicki, Milena, Dabrowska, Maciej, Szmitkowski, Wlodzimierz J, Musial, and Agnieszka M, Tycinska
Subjects: Male, Inpatients, Time Factors, Iron, Coronary Care Units, Anemia, Coronary Artery Disease, Prognosis, Risk Assessment, Survival Rate, Hemoglobins, Risk Factors, Humans, Female, Hospital Mortality, Poland, Follow-Up Studies, Retrospective Studies
Abstract: Patients admitted to an intensive cardiac care unit (ICCU) are a heterogeneous population with a high mortality rate. The aim of our study was to investigate which clinical, biochemical, and echocardiographic parameters routinely assessed may affect long-term mortality in a non-selected ICCU population.A total of 392 patients hospitalized between 2008-2011 (mean age, 70 ± 13.8 years, 43% women) were consecutively and prospectively assessed with the following admission diagnoses: 168 with acute coronary syndromes (ACS), 122 with acute decompensated heart failure (ADHF), and 102 with other acute cardiac disorders. Patients were treated according to the current European Society of Cardiology (ESC) guidelines.During a mean 29.3 (± 18.9) months of observation, 152 (38.8%) patients died and 7.9% of the patients needed a red blood cell transfusion (RBC Tx). Patients who died were significantly older and had lower baseline levels of hemoglobin (Hb), serum iron concentration (SIC), total iron binding capacity (TIBC), cholesterol, and left ventricular ejection fraction (LVEF), as well as lower eGFR values, and higher white blood cell (WBC) counts and C-reactive protein (CRP) levels (P0.05). Predictors of death in multivariate regression analysis were age, Hb, LVEF, WBC, and CRP. The most powerful factor was hospitalization for non-ACS. The risk of long-term mortality increased with decreasing levels of Hb (P0.001), SIC (P = 0.001), TIBC (P = 0.009), and the need for RBC Tx (P0.001), as well as the diagnosis of ADHF (P0.001) and the absence of ACS (P = 0.007).In ICCU patients, age, Hb, parameters of iron status, and LVEF are strong predictors of long-term mortality. Among the ICCU population, patients with ACS diagnosis have better survival.
Published: 2015

21. Lipid Peroxidation, Vitamin E, and Cardiovascular Disease

Author: J. Musial, T. B. Domagala, and A. Szczeklik
Published: 2015
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22. The potential role of statins in contrast nephropathy

Author: L. Yassine, J. Yee, K. Fisher, J. Musial, and N. Attallah
Subjects: Male, Nephrology, Cardiac Catheterization, medicine.medical_specialty, Time Factors, Statin, medicine.drug_class, medicine.medical_treatment, Urology, Contrast Media, Renal function, Nephropathy, chemistry.chemical_compound, Internal medicine, Humans, Medicine, Dialysis, Retrospective Studies, Cardiac catheterization, Creatinine, business.industry, General Medicine, Middle Aged, medicine.disease, Surgery, chemistry, Kidney Failure, Chronic, Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Kidney disease
Abstract: Background Administration of contrast agents may result in an acute reduction in renal function and occasionally end-stage renal disease. Risk factors for contrast-induced nephropathy (CN) are preexisting renal dysfunction, diabetes and reduced effective arterial volume. Hydration and use of nonionic contrast agents have been reported to ameliorate CN. Reactive oxygen species may have a role in the pathogenesis of CN. Statins decrease free oxygen radicals in animals. We retrospectively tested the hypothesis that administering statins prior to cardiac catheterization decreases the incidence of CN. Methods A total of 1,002 patients were studied. Patients with a stable baseline serum creatinine (SCr) > or = 1.5 mg/dl who had cardiac catheterization between July 1997 and June 2002, were included in the study. None of the patients were taking statins before admission. 250 patients were started on a statin before the procedure and 752 patients were not. The SCr was followed for 7 days after the procedure looking for an acute decrement in renal function, dialysis requirement and survival. Results The baseline characteristics, SCr, GFR, amount of intravenous fluids and contrast were similar in both groups. The post cath SCr (2.26 vs 3.1 mg/dl, p = 0.001) was significantly better in the statin group. Length of stay (2.72 vs 3.32 days, p = 0.01) and number of patients with acute renal failure (43 (17.2%) vs 168 (22.3%) patients, p = 0.028) were significantly lower in the statin group. Dialysis requirement within 7 days and 28-day survival were similar in both groups. Conclusion Prophylactic administration of statins along with hydration may be associated with less CN induced by a nonionic, low-osmolality contrast.
Published: 2004
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23. Erratum to: Immunoreactivity and avidity of IgG anti-β2-glycoprotein I antibodies from patients with autoimmune diseases to different peptide clusters of β2-glycoprotein I

Author: A. Artenjak, I. Locatelli, H. Brelih, D. M. Simonič, Z. Ulcova-Gallova, J. Swadzba, J. Musial, T. Iwaniec, L. Stojanovich, F. Conti, G. Valesini, T. Avčin, J. W. Cohen Tervaert, Y. Shoenfeld, M. Blank, A. Ambrožič, S. Sodin-Semrl, B. Božič, and S. Čučnik
Subjects: Immunology
Published: 2014

24. Dichloromyristic Acid, a Major Component of Organochlorine Load in Lobster Digestive Gland

Author: Jonathan M. Curtis, John F. Uthe, Charles J. Musial, Joyce E. Milley, and Robert K. Boyd
Subjects: Pulp mill, Homarus, Chromatography, biology, Extraction (chemistry), chemistry.chemical_element, General Chemistry, Fractionation, Pesticide, biology.organism_classification, chemistry, Kraft process, Environmental chemistry, polycyclic compounds, Chlorine, Environmental Chemistry, Effluent
Abstract: It is well established that PCBs and chlorinated pesticides account for only some 15% of extractable organically-bound chlorine (EOCl) in samples from marine and non-marine environments. Work by other investigators on marine sediments and lipids from highly contaminated fish, collected near kraft pulp mills, has shown that chlorinated alkanoic acids contribute significantly to the EOCl. The present investigation extends this work to lipids from lobsters (Homarus americanus) captured in an industrial harbor well removed from any pulp mill effluent. The relatively low chlorine content of these lipids (30−100 μg g-1) necessitated development of fractionation and analysis procedures more discriminating and sensitive than those used previously. Neutron activation analysis for total chlorine was used to monitor the extraction, cleanup, transesterification, and selective EOCl enrichment of the lipids. Fractionation on a Sephadex LH-20 column then concentrated the EOCl into fractions separated from the bulk of th...
Published: 1997
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25. Estimating Analytical Variances in Measurement of Polycyclic Aromatic Hydrocarbons and Application to Monitoring Contaminants in American Lobster (Homarus americanus)

Author: Rajendra K Misra, John F. Uthe, Thomas L. King, and Charles J. Musial
Subjects: Pharmacology, chemistry.chemical_classification, Homarus, biology, Decapoda, Polycyclic aromatic hydrocarbon, Zoology, American lobster, Replicate, biology.organism_classification, Crustacean, Analytical Chemistry, Toxicology, chemistry, Principal component analysis, Environmental Chemistry, Ecotoxicology, Agronomy and Crop Science, Food Science
Abstract: A method is presented for estimating replicate polycyclic aromatic hydrocarbon (PAH) concentrations in American lobster (Homarus americanus) digestive gland tissue based on recoveries of added perdeuterated surrogates from a single satisfactory analysis. PAH concentrations demonstrated a large interanimal variance, even in specimens captured at the same time in the same place. Principal component analysis showed that the variability of the total system of biological variables (carapace length, lobster weight, and digestive gland weight) could be adequately summarized by the first principal component alone in each data set. Ranks provide ordered classification of individuals, allowing data analysis by statistical methods for continuous variables (i.e., analysis of variance). PAH concentrations in individual lobsters were generally highly sensitive to animal size, sex, and fishing area. Efficient monitoring would result from analyzing individual animals of a single sex from a study area, using as small a geographical study area as possible, measuring a single biological variable, and using individual specimens of as narrow a size range as possible.
Published: 1996
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26. Collagen receptors α(1)β(1) and α(2)β(1) integrins are involved in transmigration of peripheral blood eosinophils, but not mononuclear cells through human microvascular endothelial cells monolayer

Author: S, Bazan-Socha, J, Zuk, H, Plutecka, C, Marcinkiewicz, L, Zareba, and J, Musial
Subjects: Adult, Male, Transendothelial and Transepithelial Migration, Endothelial Cells, Cell Line, Integrin alpha1beta1, Eosinophils, Microvessels, Leukocytes, Mononuclear, Humans, Female, Integrin alpha2beta1, Cells, Cultured, Snake Venoms
Abstract: Asthma development may be driven by T helper lymphocytes with eosinophils playing the role of major effector cells. Recruitment of the inflammatory cells from blood to the airways is mediated by adhesive molecules, e.g. selectins and integrins. The most important in cell trafficking are integrins containing α(4) and β(2) subunits. We hypothesized that also collagen receptors: α(1)β(1) and α(2)β(1), may be involved in cell migration to the inflammatory site in asthma. The aim of the study was to determine whether the inhibition of α(1)β(1) or α(2)β(1) integrins, affects transmigration of eosinophils and peripheral blood mononuclear cells (PBMC) through human microvascular endothelial cells monolayer (HMVEC) seeded on collagen IV coated wells in moderate persistent atopic asthmatics.PBMC from 9 asthmatics were separated by gradient centrifugation followed by negative magnetic separation of eosinophils. Snake venom derived anti-adhesive proteins: viperistatin and VP12 (potent and selective inhibitors of α(1)β(1) and α(2)β(1) integrins, respectively) as well as VLO4 (a non-selective inhibitor of α(4)β(1), α(5)β(1) and α(v)β(3) - used as a positive control), were used for inhibition studies. All anti-adhesive proteins studied, inhibited eosinophils, but only VLO4 affected PBMC transmigration through HMVEC. In bronchial asthma both collagen receptors α(1)β(1) and α(2)β(1) are likely to be involved in eosinophil transmigration to the inflammatory site. The role of α(2)β(1) on lymphocytes is probably different. As the α(2)β(1) integrin has been described as a stimulator of collagen accumulation, it might be, at least in part, responsible for asthma airway remodelling.
Published: 2012

27. Left ventricular morphology and function in diabetic and nondiabetic hemodialyzed patients

Author: Anna, Tomaszuk-Kazberuk, Jolanta, Malyszko, Hanna, Bachorzewska-Gajewska, Marcin, Kozuch, Michal, Mysliwiec, and Wlodzimierz J, Musial
Subjects: Male, Ventricular Dysfunction, Left, Echocardiography, Renal Dialysis, Case-Control Studies, Diabetes Mellitus, Humans, Kidney Failure, Chronic, Female, Middle Aged
Abstract: Morbidity in end-stage renal disease (ESRD) diabetic patients is worse than in patients without diabetes mellitus (DM). This study aims to compare clinical, laboratory, and echocardiographic features between the ESRD patients with and without DM. Fifty-eight ESRD patients on dialysis were prospectively divided into two groups according to the presence of DM. Demographic, clinical, laboratory, and echocardiographic features (ejection fraction and wall motion score index) were compared between the two groups. Overall, 20 out of 58 patients (37.8%) with ESRD had DM. There were no significant differences between the patients with DM and those without DM when it comes to age (60.6 ± 10.6 vs. 59.0 ± 10.6 years, P = 0.665), ejection fraction (52.6% ± 12.8% vs. 54.2% ± 12.8%, P = 0.59), and wall motion score index (1.21 ± 0.3 vs.1.15 ± 0.3, P = 0.37). In multivariant analysis of the interventricular septum, posterior wall thickness and left atrium size correlated positively with DM. There was also no statistical difference in myocardial perfusion disturbances on real-time contrast echocardiography between the groups with and without DM (12 (60%) patients vs. 14 patients (36.8%), P = 0.079). Among diabetics 77.8% had significant atherosclerotic changes, while in the group without DM, only 38.1%, P = 0.01. From the laboratory parameters ferritin and high-sensitivity C-reactive protein levels were significantly higher in the group with DM, P = 0.014 and P = 0.026, respectively. Patients with ESRD and DM have significantly bigger left atrial size, thicker left ventricular walls, and higher serum ferritin and high-sensitivity C-reactive protein levels than the patients without DM. The aforementioned features may be possible risk factors for the development of adverse cardiac events in patients on hemodialysis.
Published: 2011

28. Outcomes of Allogeneic Hematopoietic Stem Cell Recipients Diagnosed With Invasive Fungal Infection Prior to Transplant Procedure

Author: Krzysztof Kałwak, A. Dyla, Urszula Nawrot, J. Musial, D. Kulej, M. Mielcarek, J. Owoc-Lempacj, K. Janczak, T. Dorobisz, Alicja Chybicka, E Gorczyńska, and Marek Ussowicz
Subjects: Oncology, medicine.medical_specialty, Transplantation, medicine.anatomical_structure, business.industry, Internal medicine, medicine, Hematopoietic stem cell, Hematology, business, Transplant Procedure
Published: 2011
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29. The avidity of anti-beta 2-glycoprotein I antibodies in patients with or without antiphospholipid syndrome: a collaborative study in the frame of the European forum on antiphospholipid antibodies

Author: S, Cucnik, T, Kveder, Z, Ulcova-Gallova, G Z, Ulcova, J, Swadzba, J, Musial, G, Valesini, T, Avcin, B, Rozman, and B, Bozic
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Antibody Affinity, chemical and pharmacologic phenomena, Immunoglobulin G, Young Adult, Rheumatology, Antiphospholipid syndrome, Internal medicine, Beta 2-Glycoprotein I, Medicine, Humans, Avidity, Child, Aged, Autoantibodies, biology, business.industry, Autoantibody, Middle Aged, medicine.disease, Antiphospholipid Syndrome, carbohydrates (lipids), Europe, Venous thrombosis, anti-beta 2-glycoprotein i antibodies, anti-β2-glycoprotein i antibodies, avidity, chaotropic test, multicentric study, thrombosis, beta 2-Glycoprotein I, Immunology, biology.protein, Antibodies, Antiphospholipid, lipids (amino acids, peptides, and proteins), Female, Antibody, business
Abstract: Objective. The objective of this study was to extend the findings of the preliminary study by measuring the avidity of IgG anti-β2-glycoprotein I antibodies (anti-β2-GPI) on a larger group of patients with primary or secondary antiphospholipid syndrome (APS) and anti-β2-GPI positive patients without APS in the frame of the European Forum on antiphospholipid antibodies (aPL). Methods. Serum from 137 patients with primary APS, APS associated with autoimmune diseases, and patients with autoimmune diseases other than APS from five EU rheumatology centres were tested for anti-β2-GPI antibodies. The 109 patients who were sera positive for anti-β2-GPI by the in-house anti-β2-GPI enzyme-linked immunosorbent assay (ELISA) at the Immunology Laboratory, UMC Ljubljana were selected for further testing on avidity with chaotropic anti-β2-GPI ELISA. Results. High, low and heterogeneous avidity IgG anti-β2-GPI was found in 32/109, 17/109 and 60/109 patients respectively. Significantly more patients with APS were in the high avidity than in the low avidity anti-β2-GPI group, while the opposite was observed for non-APS (both p Conclusion. Patients with or without APS had anti-β2-GPI of high, low or heterogeneous avidity. High avidity anti-β2-GPI was associated with thrombosis and APS, while in the low avidity anti-β2-GPI group non-APS (predominantly SLE) patients prevailed. Determination of anti-β2-GPI avidity should be considered in the analytical strategies for further differentiation of patients with anti-β2-GPI antibodies.
Published: 2011

30. Early drop in systolic blood pressure and worsening renal function in acute heart failure: Renal results of Pre-RELAX-AHF

Author: Voors, A.A. Davison, B.A. Felker, G.M. Ponikowski, P. Unemori, E. Cotter, G. Teerlink, J.R. Greenberg, B.H. Filippatos, G. Teichman, S.L. Metra, M. Teichman, S.L. Massie, B.M. Goldstein, S. Bohm, M. Francis, G. Davis, C.E. Boldueva, S. Moiseev, V. Shogenov, Z. Ruda, M. Vishnevsky, A. Boyarkin, M. Simanenkov, V. Tereschenko, S. Shwartz, Y. Orlikova, O. Arkhipov, M. Libov, I. Sardinov, R. Suvorov, A. Marmor, A. Katz, A. Zimlichman, R. Omary, M. Hershkoviz, R. Goland, S. Keren, A. Aronson, D. Grzybowski, J. Musial, W. Apró, D. Lupkovics, G. Stamate, C. Salajan, A. Matei, A. Levy, P. Pang, P. Collins, S. Gupta, D. Van Mieghem, W. Muyldermans, L. Vervoort, G.
Abstract: Aims We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. Methods and resultsThe Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) for AHF and randomized them to relaxin given intravenous (i.v.) for 48 h or placebo. Blood pressure was measured at baseline, at 3, 6, 9, 12, 24, 36, and 48 h and at 3, 4, and 5 days after enrolment. Worsening renal function was defined as a serum creatinine increase of
Published: 2011

31. Trend analysis using a multivariate procedure for data with unequal residual covariance and regression coefficient matrices: Application to Canadian Atlantic cod contaminant data

Author: Charles J. Musial, R. K. Misra, C. L. Chou, D. P. Scott, and John F. Uthe
Subjects: Analysis of covariance, Multivariate statistics, Multivariate analysis, Statistics, Linear regression, Univariate, Aquatic Science, Covariance, Oceanography, Residual, Pollution, Regression, Mathematics
Abstract: Conventional univariate and multivariate analysis of covariance (ANCOVA and MANCOVA) are commonly used to investigate time trends in contaminant levels in fish tissues. Both procedures require that years do not differ in their residual variances, covariances, and regression parameters. These requirements were not met in many data sets. A multivariate procedure that does not have these requirements was used to reanalyse contaminant concentration trends in Canadian cod data collected between 1977 and 1985.
Published: 1993
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32. Lung involvement in Churg–Strauss syndrome as related to the activity of the disease

Author: W, Szczeklik, P, Grzanka, L, Mastalerz, B, Sokołowska, and J, Musial
Subjects: Adult, Lung Diseases, Male, Humans, Female, Churg-Strauss Syndrome, Tomography, X-Ray Computed
Published: 2010

33. Diagnostic biomarkers of essential arterial hypertension: the value of prostacyclin, nitric oxide, oxidized-LDL, and peroxide measurements

Author: Agnieszka M, Kuklinska, Barbara, Mroczko, Wlodzimierz J, Musial, Monika, Usowicz-Szarynska, Robert, Sawicki, Halina, Borowska, Malgorzata, Knapp, and Maciej, Szmitkowski
Subjects: Adult, Male, 6-Ketoprostaglandin F1 alpha, Coronary Artery Disease, Blood Pressure Monitoring, Ambulatory, Middle Aged, Atherosclerosis, Nitric Oxide, Prognosis, Epoprostenol, Peroxides, Lipoproteins, LDL, Stroke, Oxidative Stress, Reference Values, Risk Factors, Hypertension, Humans, Female, Endothelium, Vascular, Biomarkers
Abstract: Endothelial function is impaired in hypertensive patients. Decreased nitric oxide and prostacyclin production as well as increased oxidative stress are involved in this abnormality. The aim of the present study was to evaluate whether biomarkers of endothelial dysfunction and oxidative stress have diagnostic value in patients with essential hypertension. We measured nitric oxide, prostacyclin, and oxidized-LDL levels and assessed oxidative status in 62 patients with diagnosed essential arterial hypertension and 45 healthy controls. In the hypertensive group, among measured parameters, the median prostacyclin level was significantly lower, when compared to healthy controls (125.57 pg/mL, 25%; 75% quartile range: 84.99; 275.93 and 462.9 pg/mL, 25%; 75% quartile range: 107.69; 849.3, respectively, P = 0.009). The largest area under the ROC curve was found for prostacyclin; 0.647 (95% C.I. 0.549 to 0.737). In the analysis of logistic regression, the prostacyclin and oxidized-LDL cut-off values were associated with a 4.9 higher significant risk of hypertension (O.R. 4.91 and 4.99, respectively; P = 0.0008 and P = 0.00065, respectively). Oxidized-LDL, a biomarker of endothelial damage, was the only one that had a significant negative correlation with protective prostacyclin in hypertensive patients (r = -0.29, P = 0.02). Of all the biomarkers prostacyclin and oxidized-LDL had the best diagnostic value for patients with hypertension.
Published: 2009

34. [Ceramides and adhesive molecules in stable ischaemic heart disease]

Author: Wojciech, Modrzejewski, Malgorzata, Knapp, Agnieszka, Dobrzyn, Wlodzimierz J, Musial, and Jan, Górski
Subjects: Adult, Male, Cholesterol, HDL, Myocardial Ischemia, Cholesterol, LDL, Middle Aged, Ceramides, Intercellular Adhesion Molecule-1, Cholesterol, Case-Control Studies, Humans, Female, E-Selectin, Triglycerides, Aged
Abstract: The aim of the study was assessment of plasma level of ceramides and adhesive molecules in patients with stable ischaemic heart disease (IHD). Ischaemic heart disease was verified by coronary angiography as a 1.2 or 3 vessels disease. The study based on 35 patients (11F, 24 M,aged 40-74 yrs). The control group consisted of 16 healthy persons (5F, 11M, aged 43-66 yrs). Fasting plasma was drown to asses levels of ceramides, the soluble forms of E-selectin and intercellular adhesive molecule-1 (ICAM-1) and total cholesterol, chol-HDL, chol-LDL and triglicerides. Decreased concentrations of ceramides with mono- and polyunsaturated fatty acids were observed in patients with stable IHD. In 3 vessels disease the total level of ceramides was higher than in 1 vessel disease (p0.05). The plasma concentration of sE-selectin, ssICAM-1 were elevated in patients compared to control group (p0.02 and p0.05, respectively). The plasma levels of sICAM-1 were significantly higher in 3 vessels disease than in 1 vessel disease (p0.01). Ceramides concentration with saturated fatty acids correlated with adhesive molecules (p0.05). A negative correlation was observed between sICAM-1 concentration and ceramides with palmitoleic acid or docosahexaenoic acid (p0.05).
Published: 2008

35. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms

Author: J Musial, L H Edmunds, G J Stewart, J A Williams, S Niewiarowski, J J Cook, and B Rucinski
Subjects: Extracorporeal Circulation, Peptide, Viper Venoms, Fibrinogen, Platelet Adhesiveness, Physiology (medical), medicine, Humans, Platelet, Amino Acid Sequence, Receptor, chemistry.chemical_classification, Platelet Count, business.industry, Extracorporeal circulation, Thrombin, Degranulation, Adhesion, Platelet Activation, chemistry, Biochemistry, Biophysics, Peptides, Cardiology and Cardiovascular Medicine, business, Oligopeptides, medicine.drug
Abstract: Previous studies indicate that exposure of fibrinogen receptors associated with glycoprotein IIb/IIIa complex contributes to platelet loss during cardiopulmonary bypass. Recently, we isolated a number of RGD (Arg-Gly-Asp)-containing, low molecular weight, cysteine-rich peptides from viper venoms. These peptides, which we propose to call "disintegrins," block platelet-fibrinogen interaction and platelet aggregation. We compared the effect of RGDS (Arg-Gly-Asp-Ser) and four disintegrins (echistatin, flavoridin, albolabrin, and bitistatin) on platelet behavior in a membrane oxygenator. During simulated extracorporeal circulation for 2 hours, platelet count decreased to about 30% of initial values. Addition of echistatin (60-200 nM), albolabrin (60-200 nM), bitistatin (60 nM), and flavoridin (45 nM) significantly inhibited platelet loss in the circuit. RGDS (33 microM) did not show any significant inhibitory effect. ADP-induced platelet aggregation was inhibited in samples of platelet-rich plasma taken from the circuits containing disintegrins. However, echistatin appeared to be a more potent inhibitor of platelet aggregation, whereas albolabrin and flavoridin interfered more selectively with platelet loss from the circuit. Echistatin prevented the accumulation of glycoprotein IIIa on the surface of the circuit. Echistatin (60-200 nM), flavoridin (45 nM), bitistatin (60 nM), and albolabrin (200 nM) significantly inhibited the loss of beta-thromboglobulin from platelets into circulating plasma. Electron microscopy studies demonstrated shape change but not degranulation in platelets circulating in the presence of 200 nM echistatin. On the other hand, this peptide (up to 1,000 nM) did not prevent loss of alpha granules and beta-thromboglobulin from thrombin-stimulated platelets, although it prevented their aggregation. In conclusion, disintegrins protect platelets in the circuit by preventing their adhesion to surfaces and, therefore, preventing fragmentation of adhered platelets under the shear stress of flowing blood. This study indicates that disintegrins may be potential candidates for platelet protection during cardiopulmonary bypass.
Published: 1990
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36. Increased expression of collagen receptors: alpha1beta1 and alpha2beta1 integrins on blood eosinophils in bronchial asthma

Author: S, Bazan-Socha, A, Bukiej, G, Pulka, C, Marcinkiewicz, and J, Musial
Subjects: Adult, Collagen Type IV, Male, Receptors, Collagen, Disintegrins, Viper Venoms, Flow Cytometry, Asthma, Integrin alpha1beta1, Eosinophils, Cell Adhesion, Humans, Female, Integrin alpha2beta1
Abstract: Eosinophils are one of the major effector cells in bronchial asthma. Their infiltration of airways correlates with the asthma severity. Recruitment and activation of eosinophils are partially mediated by integrins alpha4beta1 and alpha4beta7. Collagens type I and IV constitute important components of extracellular matrix and vascular basement membrane, respectively. Therefore, collagen-binding integrins (alpha1beta1 and alpha2beta1) may also play a role in eosinophil lung infiltration.To evaluate the possible presence of alpha1beta1 and alpha2beta1 integrins on peripheral blood eosinophils from asthmatic subjects.Collagen receptors were studied on eosinophils separated by immunomagnetic CD16-negative method from healthy donors (n=13) and patients with moderate persistent atopic bronchial asthma (n=15). Surface receptor identification was performed by flow cytometry and cell adhesion assay.Eosinophils isolated from the patients showed increased expression of both alpha1beta1 and alpha2beta1 integrins as compared with healthy controls. Moreover, adhesive function of eosinophils to collagen type IV was inhibited by snake venom disintegrins: viperistatin and obtustatin. These disintegrins contain KTS active motif and are specific inhibitors of alpha1beta1 integrin.We demonstrated for the first time that collagen receptors: alpha1beta1 and alpha2beta1 integrins are overexpressed on the surface of peripheral blood eosinophils of asthmatic subjects. Further studies may reveal potential application of KTS-disintegrins or their structural analogs for therapy of bronchial asthma.
Published: 2006

37. ST segment resolution predicts clinical outcome and response to dobutamine testing after primary percutaneous transluminal coronary angioplasty

Author: A, Tomaszuk-Kazberuk, W J, Musial, and S, Dobrzycki
Subjects: Male, Heart Ventricles, Myocardial Infarction, Stroke Volume, Recovery of Function, Middle Aged, Myocardial Contraction, Ventricular Dysfunction, Left, Recurrence, Outcome Assessment, Health Care, Retreatment, Humans, Female, Poland, Prospective Studies, Angioplasty, Balloon, Coronary, Echocardiography, Stress
Abstract: To assess clinical outcome and improvement in left ventricular (LV) contractility during a six-month follow-up after successful primary percutaneous transluminal coronary angioplasty (PTCA), according to rapid ST segment resolution. The usefulness of early dobutamine echocardiography (DE) in the prediction of LV functional recovery in patients treated with primary PTCA was tested.One hundred ten consecutive patients with first acute myocardial infarction after successful primary PTCA (Thrombolysis in Myocardial Infarction (TIMI) 3 flow and stenosis of less than 30%) were divided into two groups according to whether ST segment resolution occurred 1 h after the procedure. The patients underwent clinical assessment and echocardiography (ejection fraction [EF] and wall motion index [WMI]) after primary PTCA, during DE on the fourth day of hospitalization, and again after three and six months.In patients with ST segment resolution (n=76 [69.1%]), LVEF increased significantly during the six-month follow-up (P=0.0001). Changes found in the group without ST segment resolution were insignificant (P=0.4). Early DE in patients with rapid ST segment resolution revealed significant improvements in LV contractility measured by EF and WMI. Patients without ST segment resolution had a higher incidence of death (three of 34 [8.8%] versus zero of 76 [0%], P=0.0086), reinfarction (five of 34 [14.7%] versus two of 76 [2.6%], P=0.28) and revascularization (four of 34 [11.8%] versus three of 76 [3.9%], P=0.12). The combined end point (death, reinfarction and revascularization) was significantly lower in patients with ST segment resolution (P=0.03).Rapid ST segment resolution is associated with LV contractility recovery, and a better clinical outcome and prognosis after successful primary PTCA. Early DE after primary PTCA predicts LV functional recovery. Patients with ST segment resolution are likely to respond to early dobutamine testing.
Published: 2005

38. Integrins in pulmonary inflammatory diseases

Author: Cezary Marcinkiewicz, Stanisława Bazan-Socha, J. Musial, and A. Bukiej
Subjects: Integrins, Leukocyte migration, Sarcoidosis, Angiogenesis, Disintegrins, Pulmonary Fibrosis, Integrin, Inflammation, airway remodeling, Drug Discovery, Pulmonary fibrosis, Leukocytes, medicine, Addressin, Animals, Humans, Emphysema, Pharmacology, integrin antagonists, biology, pulmonary fibrosis, Cell adhesion molecule, business.industry, Pneumonia, medicine.disease, Asthma, respiratory tract diseases, emphysema, inflammation, Immunology, Metalloproteases, biology.protein, integrins, bronchial asthma, medicine.symptom, business, Selectin
Abstract: Integrins are a family of heterodimeric transmembrane glycoproteins that mediate cell-cell and cell-matrix interactions. They participate in inflammatory reactions mainly by regulation of leukocyte migration, activation and survival. Elevated expression of the cell adhesion molecules, such as VCAM, ICAM and MAdCAM on the lumenal surface of vascular endothelial cells is a critical early event in organ inflammatory processes - including the lung. Adhesive interactions with their counter-receptors on leukocytes, selectins and integrins, result in migration of the leukocytes to the inflammed tissues. Integrins also participate in physiological and pathological reorganization of the lung structure during e.g. pneumonia healing, airway remodeling, angiogenesis, emphysema and pulmonary fibrosis. Agents that could inhibit the function of one or more of these integrins could provide a novel therapeutic strategy targeted to inhibit inflammatory and immune phenomena in the lung.
Published: 2005

39. Immune biomarkers in relation to exposure to particulate matter: a cross-sectional survey in 17 cities of Central Europe

Author: G S, Leonardi, D, Houthuijs, P A, Steerenberg, T, Fletcher, B, Armstrong, T, Antova, I, Lochman, A, Lochmanová, P, Rudnai, E, Erdei, J, Musial, B, Jazwiec-Kanyion, E M, Niciu, S, Durbaca, E, Fabiánová, K, Koppová, E, Lebret, B, Brunekreef, and H, van Loveren
Subjects: Male, Air Pollutants, Urban Population, Neutrophils, Respiratory Tract Diseases, Immunoglobulins, Environmental Exposure, Europe, Cross-Sectional Studies, Seroepidemiologic Studies, Air Pollution, Humans, Female, Lymphocyte Count, Lymphocytes, Cities, Child, Biomarkers
Abstract: Human population data on air pollution and its effects on the immune system are scarce. A survey was conducted within the framework of the Central European Study of Air Quality and Respiratory Health (CESAR) to measure a panel of immune biomarkers in children of Bulgaria, Czech Republic, Hungary, Poland, Romania, and Slovakia. Seventeen cities were chosen to represent a wide range of exposure to outdoor air pollution. In each, ambient particulate matter of less than 10 microns diameter and less than 2.5 microns diameter (PM10 and PM2.5) were measured with a Harvard impactor. Blood was collected from 366 school children aged 9 to 11 yr between 11 April and 10 May 1996. The percentage of B, total T, CD4+, CD8+, and natural killer (NK) lymphocytes was determined by flow cytometry (Becton Dickinson); total immunoglobulins of class G, M, A and E (IgG, IgM, IgA, and IgE) were measured in serum using nephelometry (Behring). Associations between PM and each log-transformed biomarker concentration were studied by linear regression, in a two-stage model. The yearly average concentrations varied from 41 to 96 micrograms/m3 for PM10 across the 17 study areas, from 29 to 67 micrograms/m3 for PM2.5, and from 12 to 38 micrograms/m3 for PM10-2.5 (coarse). Number of B, CD4+, CD8+, and NK lymphocytes increased with increasing concentration of PM, having adjusted for age, gender, parental smoking, laboratory of analysis, and recent respiratory illness. Differences in lymphocyte number were larger and statistically significant for exposure to PM2.5. Similar results were found when we examined the association between PM and lymphocyte number separately for each laboratory. Total IgG was increased with increasing concentration of PM, significantly in the case of PM2.5. When we repeated the analyses with two other statistical approaches the results did not differ from those reported here. The effect of coarse PM on lymphocyte numbers appears small in comparison to PM2.5. One possible interpretation of our findings is that long-term exposure to airborne particulates leads to inflammation of the airways and activation of the cellular and humoral immune system.
Published: 2003

40. Humoral immunosuppression in men exposed to polycyclic aromatic hydrocarbons and related carcinogens in polluted environments

Author: J Musial, Szczeklik J, Andrzej Szczeklik, Z Galuszka, E Kolarzyk, and D Targosz
Subjects: Health, Toxicology and Mutagenesis, medicine.medical_treatment, Immunoglobulins, Physiology, Immunoglobulin E, complex mixtures, chemistry.chemical_compound, Occupational Exposure, medicine, Humans, Polycyclic Aromatic Hydrocarbons, Carcinogen, biology, technology, industry, and agriculture, Public Health, Environmental and Occupational Health, Immunosuppression, Environmental exposure, Male workers, chemistry, Environmental chemistry, Humoral immunity, Carcinogens, biology.protein, Pyrene, Antibody, Research Article, Environmental Monitoring
Abstract: We evaluated humoral immunity by measuring IgG, IgA, IgM, and IgE concentrations in 274 male workers in an iron foundry in Cracow, Poland. There were two groups: 199 coke oven workers and 76 cold-rolling mill workers. The groups were similar with respect to age, length of work (average 15 years), and smoking habits. Exposure to polycyclic aromatic hydrocarbons (PAHs), assessed by personal and area monitoring, ranged from 0.2 to 50 micrograms/m3 benzo[a]pyrene in coke plant workers and was of 3-5 magnitudes higher than in the cold-rolling mill employees. Comparison of the two groups revealed a marked depression of mean serum IgG and IgA in coke oven workers (p < 0.001, Student's unpaired t-test). In the same subjects, serum IgM had a tendency to decrease, whereas serum IgE showed a trend toward higher values. Thus, workers exposed chronically to complex mixtures of air pollutants, composed primarily of PAHs, develop immunosuppression. It remains to be established whether the immunosuppression described here is related to the frequent development of lung cancer reported in coke plant employees. Workers exposed chronically to PAHs should have serum immunoglobulins monitored regularly. Images Figure 1.
Published: 1994
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41. Successful coronary stent implantation in a patient with primary antiphospholipid syndrome

Author: D. Dudek, M. Jankowski, J. Musial, and J. S. Dubiel
Subjects: Adult, Male, medicine.medical_specialty, Cardiolipins, medicine.medical_treatment, Myocardial Infarction, Enzyme-Linked Immunosorbent Assay, Polymerase Chain Reaction, Antiphospholipid syndrome, Immunopathology, Coronary stent, medicine, Humans, cardiovascular diseases, Myocardial infarction, Angioplasty, Balloon, Coronary, Autoantibodies, Autoimmune disease, Lupus anticoagulant, Vascular disease, business.industry, Anticoagulants, Hematology, General Medicine, medicine.disease, Antiphospholipid Syndrome, Primary antiphospholipid syndrome, Surgery, Lupus Coagulation Inhibitor, Prothrombin, Stents, business
Abstract: We report a 22-year-old man who successfully underwent coronary stent implantation after an acute myocardial infarction. Lupus anticoagulant and antibodies against cardiolipin and prothrombin were detected despite the absence of any underlying disease. Therefore, long-term oral anticoagulation was instituted and appeared to be effective. To our knowledge this is the first report on coronary stenting in primary antiphospholipid syndrome.
Published: 1999

42. Estimating analytical variances in measurement of polycyclic aromatic hydrocarbons and application to monitoring contaminants in American lobster (Homarus americanus)

Author: J F, Uthe, R K, Misra, T L, King, and C J, Musial
Subjects: Male, Analysis of Variance, Animals, Female, Polycyclic Aromatic Hydrocarbons, Water Pollutants, Chemical, Nephropidae
Abstract: A method is presented for estimating replicate polycyclic aromatic hydrocarbon (PAH) concentrations in American lobster (Homarus americanus) digestive gland tissue based on recoveries of added perdeuterated surrogates from a single satisfactory analysis. PAH concentrations demonstrated a large interanimal variance, even in specimens captured at the same time in the same place. Principal component analysis showed that the variability of the total system of biological variables (carapace length, lobster weight, and digestive gland weight) could be adequately summarized by the first principal component alone in each data set. Ranks provide ordered classification of individuals, allowing data analysis by statistical methods for continuous variables (i.e., analysis of variance). PAH concentrations in individual lobsters were generally highly sensitive to animal size, sex, and fishing area. Efficient monitoring would result from analyzing individual animals of a single sex from a study area, using as small a geographical study area as possible, measuring a single biological variable, and using individual specimens of as narrow a size range as possible.
Published: 1996

43. The dual diagnosis of attention-deficit/hyperactivity disorder and substance abuse: case reports and literature review

Author: H, Schubiner, A, Tzelepis, J H, Isaacson, L H, Warbasse, M, Zacharek, and J, Musial
Subjects: Adult, Male, Psychiatric Status Rating Scales, Substance-Related Disorders, Temperance, Comorbidity, Middle Aged, Drug Administration Schedule, Alcoholism, Attention Deficit Disorder with Hyperactivity, Diagnosis, Dual (Psychiatry), Methylphenidate, Humans, Follow-Up Studies
Abstract: It is now recognized that attention-deficit/hyperactivity disorder (ADHD) may persist into adulthood. A number of studies have found an association between ADHD and substance abuse. This article describes three adult patients with both ADHD and substance abuse who were treated successfully with psychostimulants. A review of the relevant literature is included.The patients were drawn from a university-based referral center for adults with ADHD. Evaluations for ADHD and substance abuse were completed. Medical therapy and follow-up were completed by the first author.All of the patients responded to psychostimulants and have remained abstinent from alcohol and other drugs for the past 2 to 3 years.This case series and review of the literature suggest that specific treatment for ADHD with psychostimulants is feasible in patients who also have substance abuse. Future studies should evaluate the prevalence of this "dual diagnosis" and the efficacy of differing management strategies.
Published: 1995

44. Applications of signal and data processing technology to vehicular traffic monitoring

Author: M. T. Busch, Samuel S. Blackman, S. W. Cantrell, and C. J. Musial
Subjects: Extended Kalman filter, Signal processing, Data processing, Transformation (function), Computer science, business.industry, Real-time computing, Aerospace, business, Traffic flow, Signal, Simulation, Advanced Traffic Management System
Abstract: This paper describes how optical sensor signal processing and data association methods that have been developed for Aerospace applications can be applied to the traffic monitoring function of Advanced Traffic Management Systems (ATMS). It first discusses techniques that have been developed for background estimation and detection of vehicles on a roadway. Then, the transformation to tracking coordinates and the multiple target tracking (MTT) algorithm that produces traffic flow observation data are outlined. An extended Kalman filter that takes observed flow data from multiple sensor sites and produces flow estimates for an entire roadway is described and its application to incident detection discussed. Preliminary results using simulated and actual freeway data are presented. Finally, techniques for presenting this data to the user and the manner in which these signal and data processing techniques relate to an overall ATMS design are outlined.
Published: 1993
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45. Polycyclic aromatic hydrocarbons in the digestive glands of the American lobster, Homarus americanus, captured in the proximity of a coal-coking plant

Author: John F. Uthe, Charles J. Musial, and Thomas L. King
Subjects: Health, Toxicology and Mutagenesis, Toxicology, Waste Disposal, Fluid, Coking plant, medicine, Animals, Polycyclic Compounds, Seawater, Coal, Coal tar, Coal Tar, Homarus, biology, business.industry, Ecology, General Medicine, Environmental exposure, American lobster, biology.organism_classification, Pollution, Crustacean, Nephropidae, Nova Scotia, Environmental chemistry, business, Digestive System, Water Pollutants, Chemical, Waste disposal, medicine.drug
Published: 1993
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46. Lipid peroxidation, vitamin E, and cardiovascular disease

Author: J. Musial, Andrzej Szczeklik, and T. B. Domagala
Subjects: Lipid Peroxides, Nutrition and Dietetics, business.industry, Vitamin E, medicine.medical_treatment, Medicine (miscellaneous), Disease, Pharmacology, Epoprostenol, Clinical trial, Lipid peroxidation, chemistry.chemical_compound, chemistry, Cardiovascular Diseases, medicine, Animals, Humans, Lipid Peroxidation, business
Published: 1992

47. Analysis of multidimensional confocal images

Author: Jagath Samarabandu, C. J. Musial, Chandima D. Edirisinghe, T. H. Lin, Hyo-gun Kim, Raj S. Acharya, Ping-chin Cheng, and R. G. Summers
Subjects: business.industry, Computer science, Confocal, Optical engineering, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Image processing, Blackboard (design pattern), Blackboard system, Characterization (materials science), Background noise, Computer vision, Artificial intelligence, business, Microscope image processing
Abstract: A confocal image understanding system was developed which uses the blackboard model of problem solving to achieve computerized identification and characterization of confocal fluorescent images (serial optical sections). The system is capable of identifying a large percentage of structures (e.g., cell nucleus) in the presence of background noise and nonspecific staining of cellular structures. The blackboard architecture provides a convenient framework within which a combination of image processing techniques can be applied to successively refine the input image. The system is organized to find the surfaces of highly visible structures first, using simple image processing techniques, and then to adjust and fill in the missing areas of these object surfaces using external knowledge, and a number of more complex image processing techniques when necessary. As a result, the image analysis system is capable of obtaining morphometrical parameters such as surface area, volume and position of structures of interest automatically. In addition, the system is also used in the characterization of inertial fusion targets where the actual target geometry was checked against ideal parameters. The system provides a powerful tool in the fields of material science and biological research such as micro-structural characterization, morphogenesis, cell differentiation, tissue organization and embryo development.© (1991) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
Published: 1991
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48. AN INTEGER SQUARE ROOT ALGORITHM

Author: Christopher J. Musial
Subjects: Combinatorics, Discrete mathematics, Square packing in a square, Square root of 3, Methods of computing square roots, Integer square root, Algorithm, Square (algebra), Square number, Fast inverse square root, Trial division, Mathematics
Abstract: Publisher Summary This chapter elaborates an integer square root algorithm. Some algorithms that perform a square root operation may require only the integer portion of the result, rather than the entire floating-point number. An example may be arranging a list of items into a nearly square table. The table will have the same number of rows, and columns, with the last row/column possibly being empty, or incomplete. The overhead of a full floating-point calculation is not necessary in this case. The algorithm presented here calculates the largest integer, which is less than, or equal to the square root of a given integer n . Given n as the number for which the square root is required, and s as the integer square root one is seeking, iteratively perform the operation.
Published: 1991
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49. Temporal trend monitoring: Contaminant levels in tissues of Atlantic cod

Author: J. F. Uthe, R. K. Misra, C. L. Chou, D. P. Scott, and C. J. Musial
Published: 1991
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50. A GOOD STRAIGHT-LINE APPROXIMATION OF A CIRCULAR ARC

Author: Christopher J. Musial
Subjects: Perimeter, Arc (geometry), Work (thermodynamics), Line segment, Geometry, Join (topology), Computer Science::Computational Geometry, Type (model theory), Arc length, Mathematics
Abstract: Publisher Summary This chapter elaborates a good straight-line approximation of a circular arc. Many geometric algorithms and spatial modeling systems work with straight lines, and straight-line polygons. It is observed that as the world does not always consist of straight lines, the need often arises for approximating a circular arc with line segments. The simplest approximation is to select points along the curve at a spacing that gives sufficient accuracy, and then join these points together into a polyline. One of the major deficiencies with this approach is that the length of the resulting polyline is less than the arc length of the original curve. It is found that if perimeter calculation is a requirement, this type of approximation is unacceptable. In addition to maintaining the original length, the polyline also must start, and stop at the same endpoints as the arc. It is observed that as one is imposing two constraints on the curve, there are two variables one must calculate.
Published: 1991
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