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Abstract Introduction The association between chronic pain and frailty might indicate that pain is an independent driver of frailty but might alternatively be explained by inclusion within frailty identification tools of morbidities that commonly lead to chronic pain. This research examines the extent to which the association of pain with frailty might be attributed to morbidities. Methods A cross-sectional analysis of older people in a UK cohort with or at risk of musculoskeletal problems or frailty (Investigating Musculoskeletal Health and Wellbeing study), used multivariable logistic regression and Z-tests to assess the degrees of associations of pain (McGill Pain Rating Index), and painful and non-painful morbidity counts with frailty (modified FRAIL questionnaire). Results Data were from 2,185 participants, 56% female, median age 73 (range 60 to 96) years. 430 (20%) participants were classified as frail. In a fully adjusted standardised model, pain (aOR 2.07 (95%CI 1.83 to 2.33) and ‘any’ morbidity aOR (1.74 (95%CI 1.54 to 1.97) were both significantly associated with frailty. When morbidity was subclassified as painful or non-painful, painful (aOR 1.48 (95%CI 1.30 to 1.68) and non-painful (aOR1.39 (95%CI 1.24 to 1.56)) morbidities each were associated with frailty, as also was pain (aOR 2.07 (95%CI 1.83 to 2.34, p

Physical scale experiments enhance our understanding of fluvial, tidal and coastal processes. However, it has proven challenging to acquire accurate and continuous data on water depth and flow velocity due to limitations of the measuring equipment and necessary simplifications during post-processing. A novel means to augment measurements is to numerically model flow over the experimental digital elevation models. We investigated to what extent the numerical hydrodynamic model Nays2D can reproduce unsteady, nonuniform shallow flow in scale experiments and under which conditions a model is preferred to measurements. To this end, we tested Nays2D for one tidal and two fluvial scale experiments and extended Nays2D to allow for flume tilting, which is necessary to steer tidal flow. The modelled water depth and flow velocity closely resembled the measured data for locations where the quality of the measured data was most reliable, and model results may be improved by applying a spatially varying roughness. The implication of the experimental data–model integration is that conducting experiments requires fewer measurements and less post-processing in a simple, affordable and labour-inexpensive manner that results in continuous spatio-temporal data of better overall quality. Also, this integration will aid experimental design.

Abstract Deltas and estuaries worldwide face the challenge of capturing sufficient sediment to keep up with relative sea‐level rise. Knowledge about sediment pathways and fluxes is crucial to combat adverse effects on channel morphology, for example, erosion which enhances bank collapse and increasing tidal penetration. Here, we construct sediment budgets which quantify annual changes for the urbanized Rhine‐Meuse Delta of the Netherlands, a typical urban delta experiences changing fluvial and coastal fluxes of sediment, engineering works and dredging and dumping activities. The delta shows a negative sediment budget (more outgoing than incoming sediment) since the 1980s, due to anthropogenic intervention. Following a large offshore port expansion, dredging in ports and harbors in the region has doubled in the past 5 years, likely due to the induced change in net sediment fluxes. In addition, the deeper navigation channels, ports, and harbors are now trapping siltier sediment, changing the sediment composition in the mouth. The removal of sediment by dredging is adverse to the necessity for sediment in heavily eroding branches. To allow for sustainable sediment management in the future and to cope with sea‐level rise, further measurements are required to properly quantify the amount of incoming sediment at the boundaries of the system and the internal mechanisms of transport. The varied response of the branches has important consequences for navigation, ecology and flood safety and management of the sediment in the system. These effects will be of pivotal importance in coming decades with similar implications for many urbanized deltas worldwide.

Vegetation enhances bank stability and sedimentation to such an extent that it can modify river patterns, but how these processes manifest themselves in full-scale estuarine settings is poorly understood. On the one hand, tidal flats accrete faster in the presence of vegetation, reducing the flood storage and ebb dominance over time. On the other hand flow-focusing effects of a tidal floodplain elevated by mud and vegetation could lead to channel concentration and incision. Here we study isolated and combined effects of mud and tidal marsh vegetation on estuary dimensions. A 2-D hydromorphodynamic estuary model was developed, which was coupled to a vegetation model and used to simulate 100 years of morphological development. Vegetation settlement, growth and mortality were determined by the hydromorphodynamics. Eco-engineering effects of vegetation on the physical system are here limited to hydraulic resistance, which affects erosion and sedimentation pattern through the flow field. We investigated how vegetation, combined with mud, affects the average elevation of tidal flats and controls the system-scale planform. Modelling with vegetation only results in a pattern with the largest vegetation extent in the mixed-energy zone of the estuary, which is generally shallower. Here vegetation can cover more than 50 % of the estuary width while it remains below 10 %–20 % in the outer, tide-dominated zone. This modelled distribution of vegetation along the estuary shows general agreement with trends in natural estuaries observed by aerial image analysis. Without mud, the modelled vegetation has a limited effect on morphology, again peaking in the mixed-energy zone. Numerical modelling with mud only shows that the presence of mud leads to stabilisation and accretion of the intertidal area and a slight infill of the mixed-energy zone. Combined modelling of mud and vegetation leads to mutual enhancement with mud causing new colonisation areas and vegetation stabilising the mud. This occurs in particular in a zone previously described as the bedload convergence zone. While vegetation focusses the flow into the channels such that mud sedimentation in intertidal side channels is prevented on a timescale of decades, the filling of intertidal area and the resulting reduction in tidal prism may cause the infilling of estuaries over centuries.

Fluvial–tidal transitions in estuaries are used as major shipping fairways and are characterised by complex bar and channel patterns with a large biodiversity. Habitat suitability assessment and the study of interactions between morphology and ecology therefore require bathymetric data. While imagery offers data of planform estuary dimensions, only for a few natural estuaries are bathymetries available. Here we study the empirical relation between along-channel planform geometry, obtained as the outline from imagery, and hypsometry, which characterises the distribution of along-channel and cross-channel bed levels. We fitted the original function of Strahler (1952) to bathymetric data along four natural estuaries. Comparison to planform estuary shape shows that hypsometry is concave at narrow sections with large channels, while complex bar morphology results in more convex hypsometry. We found an empirical relation between the hypsometric function shape and the degree to which the estuary width deviates from an ideal convergent estuary, which is calculated from river width and mouth width. This implies that the occurring bed-level distributions depend on inherited Holocene topography and lithology. Our new empirical function predicts hypsometry and along-channel variation in intertidal and subtidal width. A combination with the tidal amplitude allows for an estimate of inundation duration. The validation of the results on available bathymetry shows that predictions of intertidal and subtidal area are accurate within a factor of 2 for estuaries of different size and character. Locations with major human influence deviate from the general trends because dredging, dumping, land reclamation and other engineering measures cause local deviations from the expected bed-level distributions. The bathymetry predictor can be used to characterise and predict estuarine subtidal and intertidal morphology in data-poor environments.

Abstract Background Some older people who find standard exercise programmes too strenuous may be encouraged to exercise while remaining seated - chair based exercises (CBE). We previously developed a consensus CBE programme (CCBE) following a modified Delphi process. We firstly needed to test the feasibility and acceptability of this treatment approach and explore how best to evaluate it before undertaking a definitive trial. Methods A feasibility study with a cluster randomised controlled trial component was undertaken to 1. Examine the acceptability, feasibility and tolerability of the intervention and 2. Assess the feasibility of running a trial across 12 community settings (4 day centres, 4 care homes, 4 community groups). Centres were randomised to either CCBE, group reminiscence or usual care. Outcomes were collected to assess the feasibility of the trial parameters: level of recruitment interest and eligibility, randomisation, adverse events, retention, completion of health outcomes, missing data and delivery of the CCBE. Semi- structured interviews were conducted with participants and care staff following the intervention to explore acceptability. Results 48% (89 out of 184 contacted) of eligible centres were interested in participating with 12 recruited purposively. 73% (94) of the 128 older people screened consented to take part with 83 older people then randomised following mobility testing. Recruitment required greater staffing levels and resources due to 49% of participants requiring a consultee declaration. There was a high dropout rate (40%) primarily due to participants no longer attending the centres. The CCBE intervention was delivered once a week in day centres and community groups and twice a week in care homes. Older people and care staff found the CCBE intervention largely acceptable. Conclusion There was a good level of interest from centres and older people and the CCBE intervention was largely welcomed. The trial design and governance procedures would need to be revised to maximise recruitment and retention. If the motivation for a future trial is physical health then this study has identified that further work to develop the CCBE delivery model is warranted to ensure it can be delivered at a frequency to elicit physiological change. If the motivation for a future trial is psychological outcomes then this study has identified that the current delivery model is feasible. Trial registration ISRCTN27271501. Date registered: 30/01/2018.

Alluvial river estuaries consist largely of sand but are typically flanked by mudflats and salt marshes. The analogy with meandering rivers that are kept narrower than braided rivers by cohesive floodplain formation raises the question of how large-scale estuarine morphology and the late Holocene development of estuaries are affected by cohesive sediment. In this study we combine sand and mud transport processes and study their interaction effects on morphologically modelled estuaries on centennial to millennial timescales. The numerical modelling package Delft3D was applied in 2-DH starting from an idealised convergent estuary. The mixed sediment was modelled with an active layer and storage module with fluxes predicted by the Partheniades–Krone relations for mud and Engelund–Hansen for sand. The model was subjected to a range of idealised boundary conditions of tidal range, river discharge, waves and mud input. The model results show that mud is predominantly stored in mudflats on the side of the estuary. Marine mud supply only influences the mouth of the estuary, whereas fluvial mud is distributed along the whole estuary. Coastal waves stir up mud and remove the tendency to form muddy coastlines and the formation of mudflats in the downstream part of the estuary. Widening continues in estuaries with only sand, while mud supply leads to a narrower constant width and reduced channel and bar dynamics. This self-confinement eventually leads to a dynamic equilibrium in which lateral channel migration and mudflat expansion are balanced on average. However, for higher mud concentrations, higher discharge and low tidal amplitude, the estuary narrows and fills to become a tidal delta.

When performing in plants by grafting methods slit at the time of grafting is discarded cup rootstock. In this context, the aim of this work is to evaluate the technique of cutting in tomato plants that exhibit characteristics for use as rootstocks for tomato grafting and attachment provided by clones Cup compared to rootstocks propagated by seeds . For execution of the work, two experiments were conducted in the agricultural year 2013, for the first experiment was rooting three rootstocks: 1) wild species Solanum pennellii 'LA716', 2) access mini-tomato 6889; and 3) Witness (tomato Santa Cruz Kada®) for the second experiment we evaluated the handle grafting rootstocks propagated by cuttings, compared to the same propagated by seeds. For the first experiment, treatments rootstocks access mini-tomato 6889 and witness, provided the greatest percentage of cuttings. For the second experiment, to evaluate the variable takes grafting, it was found that tomato rootstocks propagated by cuttings provide a good grip grafting the same or similar propagated by seeds.