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2 results on '"J.E.W. Van Dijk"'

1. Outcomes of endometrial cancer prevention strategies in patients with Lynch syndrome: a nationwide cohort study in the NetherlandsResearch in context

Author

Ellis L. Eikenboom, Lotte van Leeuwen, Floris Groenendijk, Jorien M. Woolderink, Anne M. Van Altena, Monique E. Van Leerdam, Manon C.W. Spaander, Helena C. van Doorn, Anja Wagner, M.C. Breijer, A.S. Tjalsma, F. Vork, H.P.M. Smedts, J. van der Velden, M.M.A. Brood-van Zanten, J.E. van de Riet, A.L.M. Oei, H. Kessel, P.M.L.H. Vencken, M.P.L.M. Snijders, R.H.M. Hermans, A. Bouman, H.W. Ünsalan, A.M.G. van de Swaluw, G.M. Plaisier, H.C. van Doorn, K. van den Berg, W. Hofhuis, Y.A.J.M. Dabekausen, P.R. Kolk, H.T.C. Nagel, A.M.L.D. van Haaften-de Jong, A.C. van Hof, M. van den Hende, J. Kaijser, H.H. de Haan, R.A. Smit, M.W.G. Moonen-Delarue, J.J. Beltman, J.E. Martens, R. Kruitwagen, J.M. van der Ploeg, J.M. Woolderink, S.F.P.J. Coppus, M.J. Duk, M.J.A. Apperloo, C.M. Koopmans, C.C.M. Buis, H. van Meurs, E.C. Dul, B.B.J. Hermsen, A.M. van Altena, A. Baalbergen, A.A. van Ginkel-Terng, M. Baas, P. van Greunen, C.M.W.H. Smeets, H. Knipscheer, C. Schmeink, M.D. van der Laan, E.J.M. van Es, J.E.W. van Dijk, F.M.F. Rosier-van Dunné, H. Nijman, C.G. Gerestein, D. Boskamp, E.C.A.H. Scheers, M. Verbruggen, L.R. Bartelink, C.B.M. Kruijdenberg, J.M. Briët, B. Visschers, and M. Engelen

Subjects
Lynch syndrome, Gynaecological surveillance, Endometrial carcinoma, Medicine (General), R5-920
Abstract

Summary: Background: Female Lynch syndrome carriers have an increased risk of developing endometrial cancer. Regardless, research on endometrial carcinoma tumorigenesis is scarce and no uniform, evidence-based gynaecological management guidelines exist. We therefore described gynaecological surveillance and surgery outcomes in a nation-wide Lynch syndrome cohort. Methods: For this retrospective cohort study, female Lynch syndrome carriers, prospectively registered in the Dutch Lynch syndrome database (StOET), were included up to February 28th 2022. Carriers were linked to the Dutch national pathology (PALGA) database. The number of carriers with/without gynaecological surveillance, number of index carriers with endometrial carcinoma before Lynch syndrome diagnosis were assessed, as well as uptake of risk-reducing surgery and characteristics of endometrial carcinomas including the requisite for adjuvant therapy according to current guidelines. Overall survival after endometrial carcinoma diagnosis was analyzed using Kaplan Meier time to event analyses, cumulative incidence was calculated after adjusting for competing risks (death and prophylactic hysterectomy). Findings: In total, 1046 registered female Lynch syndrome carriers were eligible for surveillance, of whom 313 (30.0%) did not have surveillance and 21.4% (n = 224 of 1046) opted for prophylactic hysterectomy. In carriers with surveillance, more cases of endometrial carcinoma and hyperplasia were found than in those without (37 endometrial carcinomas (7.3%) and 28 hyperplasias (5.5%) in 506 carriers with surveillance versus 14 (2.6%) and 4 (0.7%) in 540 carriers without surveillance, respectively); carriers with surveillance were generally younger than those without (median 56 years [IQR 48–65] versus median 65 years [IQR 49–75] at database assembly, respectively; p

Published
2025
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2. Clinical auditing as an instrument to improve care for patients with ovarian cancer

Author

N. Leffers, H.T.C. Nagel, Roy F.P.M. Kruitwagen, R.A. Smit, F.A. Ten Cate, A.D. Ten Cate, S.F.P.J. Coppus, A.M.L.D. Van Haaften-de Jong, J.H.A. Vollebergh, M.J.A. Engelen, Eva Maria Roes, L.C. De Vries, P.J. Timmers, E.A. Ooms, J. Diepstraten, G.H. Jansen, W. Minderhoud-Bassie, N.M.S. Baldewpersad Tewarie, M.I. Baas, M.A. van der Aa, M. van Ham, A.J. Kruse, T.K. Schikken, T.C. Stam, I.M.W. Ebisch, J.A. Louwers, J.W. Mens, A.M.G. van de Swaluw, E. Davelaar, C.G. Gerestein, M.W. Glas, R. van de Laar, B.A.J.T. Visschers, H.P.M. Smedts, W.J. van Driel, E.B.L. van Dorst, R. Yigit, M.W.G. Moonen Delarue, W.M. van Baal, Y.W.C.M. Van der Plas – Koning, M.Y. Tjiong, L.R. Bartelink, F.M.F. Rosier-van Dunné, M.B. Verbruggen, J.G. Lange, Michel W.J.M. Wouters, C.M.W.H. Smeets, G. Fons, F.E.M. Rijcken, H.R. Verhoeve, J.W.D. de Waard, E.J.M. Van Es, J.E.W. Van Dijk, J. Briet, C.C.M. Buis, K. Overmars, A. van der Kolk, M. Kleppe, M.A. Huisman, P. Kolk, E.J.M. Robbe, M. van den Hende, M. Huisman, Brigitte F. M. Slangen, A.L. Aalders, S.M. Westenberg, H.H. Keizer, M.C. Vos, A. Baalbergen, L.N. Hofman, J. Kaijser, D. Boll, N. Reesink, D. Boskamp, P.M.L.H. Vencken, K.N. Gaarenstroom, D.H. Ngo, M.D. Wust, Gynecological Oncology, Radiotherapy, Obstetrie & Gynaecologie, MUMC+: MA Obstetrie Gynaecologie (3), MUMC+: Vrouw Moeder en Kind Centrum (3), MUMC+: MA Arts Assistenten Obstetrie Gynaecologie (9), MUMC+: MA Toegelatenen Obstetrie Gynaecologie (9), RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Medische Staf Obstetrie Gynaecologie (9), Epidemiology and Data Science, APH - Aging & Later Life, APH - Societal Participation & Health, Obstetrics and gynaecology, Amsterdam Reproduction & Development (AR&D), Targeted Gynaecologic Oncology (TARGON), Obstetrics and Gynaecology, and CCA - Cancer Treatment and Quality of Life

Subjects
Clinical audit, Adult, medicine.medical_specialty, Commission on professional and hospital activities, Adolescent, SURGERY, Best practice, SOCIETY, Quality indicators, Audit, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, Health care, Commission on professional and hospital, CENTRALIZATION, Medicine, Humans, Registries, Quality of care, Aged, Netherlands, Aged, 80 and over, Ovarian Neoplasms, activities, Gynecological oncology, OUTCOMES, Medical Audit, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], business.industry, Gynecologic neoplasms, General Medicine, Cytoreduction Surgical Procedures, Middle Aged, medicine.disease, Quality Improvement, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Case ascertainment, Oncology, 030220 oncology & carcinogenesis, Family medicine, INSTITUTE, Female, business, Ovarian cancer
Abstract

Introduction: The Dutch Gynecological Oncology Audit (DGOA) was initiated in 2014 to serve as a nationwide audit, which registers the four most prevalent gynecological malignancies. This study presents the first results of clinical auditing for ovarian cancer in the Netherlands.Methods: The Dutch Gynecological Oncology Audit is facilitated by the Dutch Institute of Clinical Auditing (DICA) and run by a scientific committee. Items are collected through a web-based registration based on a set of predefined quality indicators. Results of quality indicators are shown, and benchmarked information is given back to the user. Data verification was done in 2016. Results: Between January 01, 2014 and December 31, 2018, 6535 patients with ovarian cancer were registered. The case ascertainment was 98.3% in 2016. The number of patients with ovarian cancer who start therapy within 28 days decreased over time from 68.7% in 2014 to 62.7% in 2018 (p < 0.001). The percentage of patients with primary cytoreductive surgery decreased over time (57.8%-39.7%, P < 0.001). However, patients with complete primary cytoreductive surgery improved over time (53.5%-69.1%, P < 0.001). Other quality indicators did not significantly change over time.Conclusion: The Dutch Gynecological Oncology Audit provides valuable data on the quality of care on patients with ovarian cancer in the Netherlands. Data show variation between hospitals with regard to pre-determined quality indicators. Results of 'best practices' will be shared with all participants of the clinical audit with the aim of improving quality of care nationwide.(c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license(http://creativecommons.org/licenses/by/4.0/).

Published
2021
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