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1. Pharmacological treatment of asthma in a cohort of adults during a 20-year period: results from the European Community Respiratory Health Survey I, II and III

Author

Christer Janson, Simone Accordini, Lucia Cazzoletti, Isa Cerveri, Sebastien Chanoine, Angelo Corsico, Diogenes Seraphim Ferreira, Judith Garcia-Aymerich, David Gislason, Rune Nielsen, Ane Johannessen, Rain Jogi, Andrei Malinovschi, Jesús Martinez-Moratalla Rovira, Alessandro Marcon, Isabelle Pin, Jennifer Quint, Valerie Siroux, Enrique Almar, Valeria Bellisario, Karl A. Franklin, José A. Gullón, Mathias Holm, Joachim Heinrich, Dennis Nowak, José Luis Sánchez-Ramos, Joost J. Weyler, Deborah Jarvis, The members of the ECRHS I scientific team., P. Burney, S. Chinn, C. Luczynska, D. Jarvis, E. Lai, P. Vermeire, H. Kesteloot, J. Bousquet, D. Nowak, J. Prichard, R. de Marco, B. Rijcken, J.M. Anto, J. Sunyer, J. Alves, G. Boman, N. Nielsen, P. Paoletti, M. Abramson, J. Kutin, F. van Bastelaer, R. Jõgi, A. Taytard, I. Pin, C. Pison, F. Neukirch, R. Liard, J. Knani, H-E. Wichmann, J. Heinrich, H. Magnussen, T. Gislason, D. Gislason, A. Marinoni, I. Cerveri, M. Bugiani, C. Bucca, C. Romano, L. Cascio, C. Campello, J. Droste, M. Kerkhof, A. Gulsvik, E. Omenaas, J. Martinez-Moratalla, E. Almar, A. Mateos, M. Arévalo, A. Sánchez, M. Vizcaya, X. Aguilar, A. Teixidó, J.M. Antó, M. Kogevinas, F. Burgos, J. Castellsagué, J. Roca, JB. Soriano, A. Tobías, N. Muiñozguren, J. Ramos González, A. Capelastegui, J. Maldonado Pérez, A. Pereira, J. Sánchez, J. Quiros, I. Huerta, F. Payo, N. Lindholm, P. Plaschke, C. Janson, E. Björnsson, L. Rosenhall, E. Norrman, B. Lundbäck, U. Ackermann-Liebrich, N. Küenzli, A. Perruchoud, M. Burr, J. Layzell, R. Hall, B. Harrison, The members of the ECRHS II scientific team., J. Knox, M. Wjst, N. Kuenzli, E.H. Walters, J. Raven, J. Weyler, M. van Sprundel, V. Nelen, A. Soon, C. Raherison, J. Ferran-Quentin, B. Leynaert, M. Zureik, P.J. Bousquet, C. Frye, I. Meyer, E. Bjornsson, K.B. Jörundsdóttir, S. Villani, M. Ponzio, F. Frigerio, M. Comelli, M. Grassi, A. Corsico, R. Bono, P. Piccioni, E. Caria, A. Carosso, E. Migliore, G. Castiglioni, G. Verlato, E. Zanolin, S. Accordini, A. Poli, V. Lo Cascio, M. Ferrari, I. Cazzoletti, C. Svanes, B. Laerum, J. Martinez-Moratalla Rovira, C. Boix, G. González, J.M. Ignacio García, J. Solera, J. Damián, J.P. Zock, X. Basagaña, A. Jaen, C. Acosta, N. Muñozguren, J. Ramos, I. Urrutia, U. Aguirre, J. Maldonado, J.L. Sanchez, A. de la Vega, L. Palenciano, J. Azofra, A. Cañada, K. Toren, L. Lillienberg, A.C. Olin, B. Balder, A. Pfeifer-Nilsson, R. Sundberg, D. Norback, G. Wieslander, M. Gunnbjornsdottir, M. Soderberg, K.A. Franklin, B. Lundback, B. Forsberg, L. Nystrom, B. Dibbert, M. Hazenkamp, M. Brutsche, D. Seaton, The members of the ECRHS III scientific team., M. Tumilty, J. Potts, T. Gislasson, T. Rochat, B. Leyneart, G. Benke, S. Dharmage, B. Thompson, S. Kaushik, M. Matheson, H. Bentouhami, H. Orru, P.O. Girodet, V. Siroux, J. Ferran, J.L. Cracowski, P. Demoly, A. Bourdin, I. Vachier, D. Soussan, D. Courbon, C. Neukirch, L. Alavoine, X. Duval, I. Poirier, E. Becker, G. Woelke, O. Manuwald, A-M. Kirsten, B. Benediktsdottir, E.S. Arnardottir, M. Clausen, G. Gudmundsson, L. Gudmundsdottir, H. Palsdottir, K. Olafsdottir, S. Sigmundsdottir, K. Bara-Jörundsdottir, A. Grosso, F. Albicini, E. Gini, E.M. Di Vincenzo, V. Ronzoni, F. Campanella, M. Gnesi, F. Manzoni, L. Rossi, O. Ferraro, R. Tassinari, V. Bellisario, G. Trucco, L. Calciano, L. Cazzoletti, A.M. Fratta Pasini, F. Locatelli, P. Marchetti, A. Marcon, E. Montoli, G. Nguyen, M. Olivieri, C. Papadopoulou, C. Posenato, G. Pesce, P. Vallerio, H.M. Boezen, A. Johannessen, T. Skorge, F. Gomez Real, S. García, A. Núñez, P. López, R. Sánchez, E. Mancebo, J-M. Antó, J. Garcia-Aymerich, A.E. Carsin, C. Sanjuas, S. Guerra, B. Jacquemin, P. Davdand Galdakao, S. Pascual, J. Antonio Maldonado, J.L. Sánchez, L. Palacios, N. Sánchez, M. Fernández, B. Robles, K. Torén, M. Holm, J-L. Kim, A-C. Olin, A. Dahlman-Höglund, L. Braback, L. Modig, B. Järvholm, K.A. Bertilsson, H. Franklin, C. Wahlgreen, B. Andersson, U. Spetz Nystrom, G.M. Bodinaa Lund, K. Nisser, N.M. Probst-Hensch, N. Künzli, D. Stolz, C. Schindler, J.M. Gaspoz, E. Zemp Stutz, M. Adam, C. Autenrieth, I. Curjuric, J. Dratva, A. Di Pasquale, R. Ducret-Stich, E. Fischer, L. Grize, A. Hensel, D. Keidel, A. Kumar, M. Imboden, N. Maire, A. Mehta, H. Phuleria, M. Ragettli, M. Ritter, E. Schaffner, G.A. Thun, A. Ineichen, T. Schikowski, M. Tarantino, M. Tsai, S. Kapur, R. Newson, N. Innes, and A. Wilson

Subjects
Medicine
Abstract

Asthma often remains uncontrolled, despite the fact that the pharmacological treatment has undergone large changes. We studied changes in the treatment of asthma over a 20-year period and identified factors associated with the regular use of inhaled corticosteroid (ICS) treatment. Changes in the use of medication were determined in 4617 randomly selected subjects, while changes in adults with persistent asthma were analysed in 369 participants. The study compares data from three surveys in 24 centres in 11 countries. The use of ICSs increased from 1.7% to 5.9% in the general population and the regular use of ICSs increased from 19% to 34% among persistent asthmatic subjects. The proportion of asthmatic subjects reporting asthma attacks in the last 12 months decreased, while the proportion that had seen a doctor in the last 12 months remained unchanged (42%). Subjects with asthma who had experienced attacks or had seen a doctor were more likely to use ICSs on a regular basis. Although ICS use has increased, only one-third of subjects with persistent asthma take ICSs on a regular basis. Less than half had seen a doctor during the last year. This indicates that underuse of ICSs and lack of regular healthcare contacts remains a problem in the management of asthma.

Published
2019
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4. A Wind of Change

Author

S. Tsipra, E. Begliomini, José Morera, Özden Günel, Satoshi Kitamura, Giuliano Ciappi, Simonetta Baldi, S. Loukides, Ziya Kumcuoğlu, Manabu Inuzuka, Kunter Perim, A. Breitenbücher, Roser Gomez, K. Christou, P. Panagou, Yoshiki Ishii, E. Fité, Ramon Coll, Emel Çelikten, Kazuhiko Suzuki, Hiroshi Tanaka, Salvatore Valente, Murat Sungur, Giorgio Fumagalli, L. Bernardi, O. Appenzeller, Juan Ruiz, Turgay Celikel, C.T. Bolliger, Hüdaver Alper, Basel H. Herzog, C. Passino, Marino De Rosa, Vienna F. Kummer, Ümit Bayol, Timur Köse, J.M. Antó, Takashi Shibusa, Berrin Ceyhan, Giuseppe Maria Corbo, Shoji Ohno, Francesco Pistelli, A. Efthimiou, Çiǧdem Ataizi Çelikel, Pilar Romero, Ezio M. Ferdeghini, Ufuk Çağırıcı, José Antonio Fiz, Semra Bilaceroglu, Giovanni Viegi, Khalid Rauf, I. Mankovskaya, B. Hamos, Masashi Bando, M. Solèr, Annalisa Carlucci, N. Kalogeropoulos, R. Gayer, D. Giachino, K.I. Gourgoulianis, C. Mordasini, Peter V. Dicpinigaitis, Takuya Fujishima, Emine Osma, Berrin Baǧcı Ceyhan, Yoshie Shibuya, J.M. Alsina, T. Serebrovskaya, I. Karaban, Despina Rizopoulou, Shosaku Abe, José Izquierdo, J. Morera, and M.C. Hernandez

Subjects
Pulmonary and Respiratory Medicine, business.industry, Ecology, Environmental resource management, Medicine, business
Published
1998
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5. Generational increase of self-reported first attack of asthma in fifteen industrialized countries

Author

J. Sunyer, J.M. Antó, A Tobias, P Burney, and null for the European CommunityRespiratory Health Study (ecrhs)

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pediatrics, business.industry, Public health, Incidence (epidemiology), medicine.disease, Cohort effect, Relative risk, Epidemiology, Cohort, medicine, business, Developed country, Demography, Asthma
Abstract

The prevalence of asthma has increased worldwide. However, there is only local evidence for changes in incidence. Data from the European Community Respiratory Heath Survey (ECRHS) can be analysed to reconstruct trends in incidence from 1946-1991 in cohorts born between 1946-1971 in 35 areas corresponding to 15 countries. The authors report the time trends in self-reported first occurrence of asthma and its geographical distribution. All centres completed the same cross-sectional study in 1991-92. A total of 17,613 individuals (63% of those randomly selected) were included. Recall of age of first asthma attack was recorded at an interview at one point in time in subjects aged 20-44 yrs. Relative risk of asthma by cohort was estimated using survival methods with age as the time scale. Yearly incidence of asthma increased progressively by birth cohort. The relative risks were 1.12 (0.94-1.34), 1.39 (1.17-1.66), 2.01 (1.60-2.51), and 2.33 (1.81-2.98) for the cohorts born in the years 1951-55, 1956-60, 1961-65, and 1966-71, respectively, in comparison with the cohort born in the years 1946-50. The increase occurred concurrently in most of the countries, in both males and females, and both in childhood and adulthood onset asthma. These results are consistent with a generational increase in asthma incidence during the previous decades (explained by both a period and/or a cohort effect), although some of the findings could be explained by generational increases in asthma diagnosis.

Published
1999
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6. Farewell and Many Thanks

Author

C. Passino, Özden Günel, M. Solèr, N. Kalogeropoulos, D. Giachino, S. Loukides, Simonetta Baldi, Emine Osma, J.M. Alsina, Murat Sungur, Marino De Rosa, E. Fité, T. Serebrovskaya, S. Tsipra, Turgay Celikel, Vienna F. Kummer, Ufuk Çağırıcı, Çiǧdem Ataizi Çelikel, Berrin Ceyhan, E. Begliomini, José Morera, I. Karaban, José Antonio Fiz, Hiroshi Tanaka, Despina Rizopoulou, I. Mankovskaya, Francesco Pistelli, Salvatore Valente, Masashi Bando, Hüdaver Alper, Pilar Romero, Shosaku Abe, Giovanni Viegi, Khalid Rauf, Satoshi Kitamura, C.T. Bolliger, Giuseppe Maria Corbo, Shoji Ohno, Yoshiki Ishii, Semra Bilaceroglu, Juan Ruiz, Roser Gomez, Berrin Baǧcı Ceyhan, Ramon Coll, Manabu Inuzuka, A. Breitenbücher, P. Panagou, B. Hamos, Giuliano Ciappi, J.M. Antó, Emel Çelikten, José Izquierdo, J. Morera, Annalisa Carlucci, R. Gayer, O. Appenzeller, Giorgio Fumagalli, L. Bernardi, K.I. Gourgoulianis, Peter V. Dicpinigaitis, Takuya Fujishima, Kazuhiko Suzuki, Basel H. Herzog, Yoshie Shibuya, Ziya Kumcuoğlu, K. Christou, A. Efthimiou, Ezio M. Ferdeghini, Kunter Perim, Takashi Shibusa, M.C. Hernandez, Ümit Bayol, Timur Köse, and C. Mordasini

Subjects
Pulmonary and Respiratory Medicine, business.industry, Art history, Medicine, business
Published
1998
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8. SEVERE CHRONIC ALLERGIC (AND RELATED) DISEASES: A UNIFORM APPROACH — A MEDALL-GA2LEN-ARIA POSITION PAPER IN COLLABORATION WITH THE WHO COLLABORATING CENTER FOR ASTHMA AND RHINITIS (ENGLISH & RUSSIAN VARIANTS)

Author

J. Bousquet, J.M. Anto, P. Demoly, H.J. Schunemann, A. Togias, and M. Akdis

Subjects
Pediatrics, RJ1-570, Therapeutics. Pharmacology, RM1-950
Abstract

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria, atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as co-morbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.Key words: IgE, allergy, severity, control, risk, asthma, rhinitis, rhinosinusitis, urticaria, atopic dermatitis.

Published
2011

11. Health education for prevalent problems in prison, Ocaña-I proyect (Spain)

Author

C. Maestre-Miquel, C. Zabala-Baños, J.A. García, and J.M. Antolín

Subjects
educación en salud, prisiones, servicios de salud comunitaria, evaluación de programas y proyectos de salud, hábitos, percepción, salud mental, españa, Medicine, Public aspects of medicine, RA1-1270
Abstract

Objective: Pilot project focusing on the implementation and evaluation of a health education (HE) program for inmates of the prison of Ocaña I (Spain). The objective was to analyze the intentions for change in health habits and perceptions, and to assess whether the HE-program had differential effects depending on whether the participants belonged to the PAIEM or not and their socio-demographic characteristics. Methodology: The participants were 65 men, who answered an ad hoc questionnaire at the end of each session. Data analysis applied was univariate and bivariate (one-way ANOVA, t-test for Equality of Means and Chi-Square test). Results: The average rating of the sessions was 3.51 out of 4 (SD = 0.62). The percentage of positive answers about the intention to adopt healthy habits was higher among non-PAIEM subjects (84.8%) than among those who were part of this program (57.9%). All subjects having a couple indicated an intention to change negative habits, compared to 67.3% for those without a couple. The percentage of subjects who said that their perception on the issue had changed was highest among those without education (89.7%) than among those with education (61.5%). Conclusions: The evaluation of implanted HE-program implemented in the Ocaña I prison was very positive, there are differences between subjects belonging to the PAIEM and those who do not.

12. Fibromuscular dysplasia: unusual cause of abdominal pain

Author

M. Alonso-Alcañiz, J.M. Antolín, J.R. Rebolledo, and C. Muñoz-Montano

Subjects
prisons, fibromuscular displasia, infarction, hypertension, renovascular, dissection, renal artery, abdominal pain, spain, Medicine, Public aspects of medicine, RA1-1270
Abstract

Spontaneous dissection of the renal artery is a rare phenomenon, and is more common amongst men. It is not a frequent cause of abdominal pain², which is why diagnosis is often late. The case under study is a 45 year old patient that presented sudden pain in the left renal fossa of 12 hours evolution, with no findings from the basic laboratory tests (lab testing, urinary sediment and ultrasound), an abdominal CAT was therefore carried out, which showed areas of renal infarction, as well as an emergency arteriogram, which gave findings of a possible Fibromuscular Dysplasia of the left intrarenal artery as the first diagnostic probability with a partially thrombosed focal dissection.

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