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306 results on '"JENNINGS, G. L."'

6. P775Acute coronary syndromes: mechanistic insights and risk prediction through lipoprotein lipidomics

Author

Kingwell, B A, primary, Formosa, M F, additional, Mellett, N A, additional, Jayawardana, K A, additional, Giles, C, additional, Bertovic, D A, additional, Jennings, G L, additional, Childs, W, additional, Reddy, M, additional, Baradi, A, additional, Nanayakkara, S, additional, Wilson, A M, additional, Duffy, S J, additional, and Meikle, P J, additional

Published
2018
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11. Oculogravic illusion in response to straight-ahead acceleration of a CF-104 aircraft

Author

Graybiel, A, Jennings, G. L, Johnson, W. H, Money, K. E, and Malcolm, R. E

Subjects
Aerospace Medicine
Abstract

Experimental subjects wore goggles that restricted monocular vision to a luminous line fixed relative to the head, and they were exposed on one occasion to a straight-ahead acceleration of an aircraft and on another occasion to a tilting chair. The magnitude of change of direction of the resultant acceleration was the same on both occasions, but the perceived movement of the luminous line from the two stimuli was very different. In response to the aircraft stimulus, the oculogravic illusion was experienced and the luminous line was perceived as tilting relative to the subject, in response to the tilting chair stimulus, the line was perceived as remaining fixed relative to the subject. It was concluded that the oculogravic illusion, as experienced in the aircraft (and previously in centrifuges), is a true illusion and not merely a fact of physics.

Published
1979

24. Aging effects on human sympathetic neuronal function

Author

Esler, M. D., primary, Turner, A. G., additional, Kaye, D. M., additional, Thompson, J. M., additional, Kingwell, B. A., additional, Morris, M., additional, Lambert, G. W., additional, Jennings, G. L., additional, Cox, H. S., additional, and Seals, D. R., additional

Published
1995
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39. Substituting Lifestyle Management for Pharmacological Control of Blood Pressure: A Pilot Study in Australian General Practice.

Author

REID, C. M., MAHER, T., and JENNINGS, G. L.

Subjects
HYPERTENSION, BLOOD pressure, PLACEBOS
Abstract

The HEART project was conducted in general practice to determine whether lifestyle strategies, aimed at increasing physical activity and dietary modification, can be substituted for drug therapy in patients who have been well controlled on antihypertensive medication. In addition to blood pressure (BP) and risk factor outcomes, lifestyle behaviours, quality of life of patients, and the acceptability of the approach to both general practitioners (GPs) and patients involved in the trial were assessed. Patients (n = 45) with a history of hypertension and who had been well controlled for at least the past 6 months (BP < 160/95 mmHg) were randomised to a continued medication (C) group (n = 24) or a withdrawal (W) group (n = 21). Subjects had received antihypertensive therapy for an average of 7.8 years (range 1-28 years). Drug therapy in the W group was recommenced if BP exceeded 160/95 mmHg on two consecutive visits. Both groups were counselled regarding lifestyle behaviour change by their GP throughout the study and were provided with specifically developed self-help materials. Subjects were reviewed at least monthly over a 9-month period. Following randomisation, there were no significant differences between the two groups for BP, heart rate, age, duration of therapy, total cholesterol or body mass index. All but three subjects (one from the W and two from the C group) completed 9 months of monitoring following randomisation and there were no cardiovascular events; 71% of subjects remained off drug therapy and were well controlled at the 9-month follow-up (15/21) with mean BP of 141/85 mmHg (W) and 139/86 mmHg (C). Systolic BP tended to increase during the study period in both W and C groups, however, no significant differences were observed in mean systolic or diastolic BP either between the two groups or within each group in comparison to baseline values. Resting heart rate, body mass index and cholesterol levels remained unchanged in both W and C groups after 9 months follow-up. There were no changes attributable to the lifestyle intervention in the subjects continuing drug therapy in BP or lifestyle variables over the study period. However, the group stopping therapy had a 6% reduction in body mass index after 9 months. These data suggest that a proportion of motivated patients willing to trial a lifestyle approach can cease drug therapy and be adequately maintained by the prescription of lifestyle advice via their GP for at least a 9-month period. Cessation of drug therapy may be an important motivating factor to achieve weight loss in this group. [ABSTRACT FROM AUTHOR]

Published
2000
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41. Postprandial silent ischaemia following a fatty meal in patients with recently diagnosed coronary artery disease.

Author

Rajkumar, C, Simpson, H, Jennings, G L, and Dart, A M

Subjects
SILENT myocardial ischemia, CORONARY disease, PATIENTS
Abstract

Silent myocardial ischaemia (SI) is recognised as an important prognostic factor in patients with coronary artery disease (CAD). Postprandial angina is related to severity of CAD. The effect of postprandial metabolic changes in the pathogenesis of SI is unclear. We studied the postprandial changes in glucose, insulin and triglyceride, and non-esterified fatty acids (NEFA) in relation to postprandial SI and exercise capacity, in patients with CAD. Forty elderly volunteers (63 ± 1 years) mean age ± s.e.m., with a history of angina were selected on the basis of a Rose questionnaire and a positive exercise stress test (modified Bruce protocol). The test meal contained 45% fat. The meal was consumed at 9.00 am and hourly blood samples were taken for glucose, insulin, triglyceride and NEFA. Continuous Holter monitoring for SI was conducted using a Space-labs 2000 monitor. Twenty-five percent of the subjects had episodes of silent ischaemia. Postprandial glucose, insulin, triglyceride, and NEFA were not significantly different in the patients with SI (group 1, n = 10) compared with those without SI (group 2, n = 30). The mean exercise time was 6.1 ± 0.8 min in group 1 compared with 6.8 ± 0.5 minutes in group 2 (P = 0.48). The time to onset of ST depression during exercise test was also not significantly different in the two groups. The occurrence of postprandial SI cannot be related to changes in plasma levels of glucose, triglyceride, insulin, and NEFA. The explanation is not apparent from this study but may relate to a haemodynamic changes such as mesenteric steal. [ABSTRACT FROM AUTHOR]

Published
2000
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