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1. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Author

Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Latvala, Antti, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Freitas, Duarte L, Maia, José Antonio, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J, Cutler, Tessa L, Hopper, John L, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik KE, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, Nelson, Tracy L, Whitfield, Keith E, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H, Fisher, Abigail, Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Baker, Laura A, Tuvblad, Catherine, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Burt, S Alexandra, Klump, Kelly L, Silberg, Judy L, Maes, Hermine H, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas S, Harden, K Paige, Tucker-Drob, Elliot M, Franz, Carol E, Kremen, William S, Lyons, Michael J, Lichtenstein, Paul, Bartels, Meike, Beijsterveldt, Catharina EM van, Willemsen, Gonneke, Öncel, Sevgi Y, Aliev, Fazil, Jeong, Hoe-Uk, Hur, Yoon-Mi, Turkheimer, Eric, Boomsma, Dorret I, Sørensen, Thorkild IA, Kaprio, Jaakko, and Silventoinen, Karri

Subjects
Biological Psychology, Health Sciences, Psychology, Pediatric, Genetics, 2.1 Biological and endogenous factors, Quality Education, Adolescent, Adult, Body Height, Child, Child, Preschool, Environment, Female, Gene-Environment Interaction, Genetic Background, Humans, Infant, Infant, Newborn, Male, Parenting, Parents, Quantitative Trait Loci, Quantitative Trait, Heritable, Young Adult
Abstract

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.

Published
2020

3. Genetic and environmental effects on body mass index from infancy to the onset of adulthood: an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study1–3

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Möller, Sören, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J, Jang, Kerry L, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P, Huibregtse, Brooke M, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Heikkilä, Kauko, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Stazi, Maria A, Fagnani, Corrado, D’Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A, Bartels, Meike, van Beijsterveldt, Toos CEM, Craig, Jeffrey M, Saffery, Richard, Freitas, Duarte L, Maia, José Antonio, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G, Medland, Sarah E, Montgomery, Grant W, Chong, Youngsook, Swan, Gary E, Krasnow, Ruth, Magnusson, Patrik KE, Pedersen, Nancy L, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire MA, Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K Paige, Tucker-Drob, Elliot M, Öncel, Sevgi Y, Aliev, Fazil, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A, Tuvblad, Catherine, Duncan, Glen E, Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H, Sørensen, Thorkild IA, Boomsma, Dorret I, and Kaprio, Jaakko

Published
2016
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4. Impact of adverse occupational factors on the depression status of maternal women.

Author

SONG Qing, LIU Hui, JI Fuling, LIU Zhisheng, GUO Xiaohui, CHEN He, YU Wenlan, YU Changyan, and LUO Zhiyong

Subjects
DEPRESSION in women, MARRIED women, MARITAL status, OCCUPATIONAL hazards, LOGISTIC regression analysis, PREGNANT women
Abstract

Objective To understand the depression status of maternal women and its association with occupational factors. Methods From April to July 2018, using the convenient sampling method, a total of 1 073 maternal women were investigated by the self-rating depression scale (SDS). Results Among 1 073 pregnant women, 233 had depression, with a prevalence of 21.7%, while the incidence of mild, moderate, and severe depression was 17.9%, 3.2%, and 0.7%, respectively. Multivariate logistic regression analysis showed that the risk of depression was reduced in those with a graduate degree or higher compared with those with junior high school education and below (OR = 0.13, 95%CI: 0.04 - 0.45). The maternal women in marital conditions (such as unmarried, cohabitation, widows, and divorced) had a higher risk of depression compared to women in married conditions (OR = 9.04, 95%CI: 1.62 - 50.53); while the maternal women working longer than 40 hours per week during pregnancy (versus less than 30 hours per week), sitting or walking for a long time (versus standing for a long time), and being exposed to occupational hazards (versus non-exposed) had a higher risk of depression, the OR were 2.52 (95%CI: 1.30-4.91), 3.28 (95%CI: 1.34-8.02), 2.00 (95%CI: 1.28-3.11), and 2.67 (1.78 -3.99), respectively. Additionally, compared to those who did not adjust their job position or workload after pregnancy, maternal women who adjusted their jobs or reduced their work intensity after pregnancy had a reduced risk of depression of 0.50 (95%CI: 0.32 -0.77). Conclusions Adverse occupational factors can have an impact on maternal depression. It is advisable to avoid prolonged standing and exposure to occupational hazards, rationally arrange work hours, adjust work positions and reduce work intensity. Health education should be conducted to reduce the incidence of maternal depression. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H, Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos CEM, Ooki, Syuichi, Saudino, Kimberly J, Stazi, Maria A, Fagnani, Corrado, D’Ippolito, Cristina, Nelson, Tracy L, Whitfield, Keith E, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L, Hopper, John L, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire MA, Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I, Sørensen, Thorkild IA, Kaprio, Jaakko, and Silventoinen, Karri

Published
2017
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6. Parental education and genetics of body mass index from infancy to old age: a pooled analysis of 29 twin cohorts

Author

Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Yokoyama, Yoshie, Sund, Reijo, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Aaltonen, Sari, Piirtola, Maarit, Freitas, Duarte L, Maia, José A, Öncel, Sevgi Y, Aliev, Fazil, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J, Cutler, Tessa L, Hopper, John L, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik KE, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina EM, Nelson, Tracy L, Whitfield, Keith E, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H, Fisher, Abigail, Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Baker, Laura A, Tuvblad, Catherine, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth JF, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Silberg, Judy L, Maes, Hermine H, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A, Harris, Jennifer R, Nilsen, Thomas S, Harden, K Paige, Tucker-Drob, Elliot M, Franz, Carol E, Kremen, William S, Lyons, Michael J, Lichtenstein, Paul, Jeong, Hoe-Uk, Hur, Yoon-Mi, Boomsma, Dorret I, Sørensen, Thorkild IA, and Kaprio, Jaakko

Subjects
Adult, Male, Parents, Adolescent, parental education, Twins, nutritional and metabolic diseases, Infant, body mass index, Middle Aged, Article, Cohort Studies, Young Adult, Child, Preschool, Humans, genetics, Female, Gene-Environment Interaction, international comparisons, Child, Aged
Abstract

Objective: To analyze how parental education modifies the genetic and environmental variances of body mass index (BMI) from infancy to old age in three geographic-cultural regions. Methods: A pooled sample of 29 cohorts including 143 499 twin individuals with information on parental education and BMI from 1 to 79 years (299 201 BMI measures) was analyzed by genetic twin modeling. Results: Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low educational category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia. Conclusions: Lower parental education is associated with higher mean and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay between genetic predisposition, childhood social environment and macro-social context is important for socio-economic differences in BMI.

Published
2019

9. Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education

Author

Fisiología, Genética, antropología física y fisiología animal, Fisiologia, Genetika,antropologia fisikoa eta animalien fisiologia, Jelenkovic Moreno, Aline, Sund, Reijo, Yokoyama, Yoshie, Latvala, Antti, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Freitas, Duarte L., Maia, José Antonio, Knafo Noam, Ariel, Mankuta, David, Abramson, Lior, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato Ochoa, Esther Matilde, Saudino, Kimberly J., Cutler, Tessa L., Hopper, John L., Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Nelson, Tracy L., Whitfield, Keith E., Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H., Fisher, Abigail, Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Baker, Laura A., Tuvblad, Catherine, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Harden, K. Paige, Tucker-Drob, Elliot M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Lichtenstein, Paul, Bartels, Meike, Van Beijsterveldt, Catharina E. M., Willemsen, Gonneke, Öncel, Sevgi Y., Aliev, Fazil, Jeong, Hoe-Uk, Hur, Yoon-Mi, Turkheimer, Eric, Boomsma, Dorret I., Sørensen, Thorkild I. A., Kaprio, Jaakko, Silventoinen, Karri, Fisiología, Genética, antropología física y fisiología animal, Fisiologia, Genetika,antropologia fisikoa eta animalien fisiologia, Jelenkovic Moreno, Aline, Sund, Reijo, Yokoyama, Yoshie, Latvala, Antti, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Freitas, Duarte L., Maia, José Antonio, Knafo Noam, Ariel, Mankuta, David, Abramson, Lior, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato Ochoa, Esther Matilde, Saudino, Kimberly J., Cutler, Tessa L., Hopper, John L., Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Nelson, Tracy L., Whitfield, Keith E., Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H., Fisher, Abigail, Medda, Emanuela, Nisticò, Lorenza, Toccaceli, Virgilia, Baker, Laura A., Tuvblad, Catherine, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Harden, K. Paige, Tucker-Drob, Elliot M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Lichtenstein, Paul, Bartels, Meike, Van Beijsterveldt, Catharina E. M., Willemsen, Gonneke, Öncel, Sevgi Y., Aliev, Fazil, Jeong, Hoe-Uk, Hur, Yoon-Mi, Turkheimer, Eric, Boomsma, Dorret I., Sørensen, Thorkild I. A., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis.

Published
2020

10. Parental Education And Genetics Of Bmi From Infancy To Old Age: A Pooled Analysis Of 29 Twin Cohorts

Author

Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Yokoyama, Yoshie, Sund, Reijo, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Aaltonen, Sari, Piirtola, Maarit, Freitas, Duarte L., Maia, Jose A., Oncel, Sevgi Y., Aliev, Fazil, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J., and Cutler, Tessa L.

Subjects
nutritional and metabolic diseases
Abstract

Objective The objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions. Methods A pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling. Results Until 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia. Conclusions Lower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

Published
2019

11. Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Latvala, Antti, additional, Yokoyama, Yoshie, additional, Sund, Reijo, additional, Sugawara, Masumi, additional, Tanaka, Mami, additional, Matsumoto, Satoko, additional, Aaltonen, Sari, additional, Piirtola, Maarit, additional, Freitas, Duarte L., additional, Maia, José A., additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Saudino, Kimberly J., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K. E., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Sung, Joohon, additional, Kim, Jina, additional, Lee, Jooyeon, additional, Lee, Sooji, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Medda, Emanuela, additional, Nisticò, Lorenza, additional, Toccaceli, Virgilia, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Knafo‐Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Harris, Jennifer R., additional, Nilsen, Thomas S., additional, Harden, K. Paige, additional, Tucker‐Drob, Elliot M., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Lichtenstein, Paul, additional, Jeong, Hoe‐Uk, additional, Hur, Yoon‐Mi, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2019
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12. Parental Education and Genetics of BMI from Infancy to Old Age:A Pooled Analysis of 29 Twin Cohorts

Author

Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Yokoyama, Yoshie, Sund, Reijo, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Aaltonen, Sari, Piirtola, Maarit, Freitas, Duarte L., Maia, Jose A., Oncel, Sevgi Y., Aliev, Fazil, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J., Cutler, Tessa L., Hopper, John L., Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Nelson, Tracy L., Whitfield, Keith E., Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H., Fisher, Abigail, Medda, Emanuela, Nistico, Lorenza, Toccaceli, Virgilia, Baker, Laura A., Tuvblad, Catherine, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Harris, Jennifer R., Nilsen, Thomas S., Harden, K. Paige, Tucker-Drob, Elliot M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Lichtenstein, Paul, Jeong, Hoe-Uk, Hur, Yoon-Mi, Boomsma, Dorret I., Sørensen, Thorkild I. A., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Yokoyama, Yoshie, Sund, Reijo, Sugawara, Masumi, Tanaka, Mami, Matsumoto, Satoko, Aaltonen, Sari, Piirtola, Maarit, Freitas, Duarte L., Maia, Jose A., Oncel, Sevgi Y., Aliev, Fazil, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Saudino, Kimberly J., Cutler, Tessa L., Hopper, John L., Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Nelson, Tracy L., Whitfield, Keith E., Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Llewellyn, Clare H., Fisher, Abigail, Medda, Emanuela, Nistico, Lorenza, Toccaceli, Virgilia, Baker, Laura A., Tuvblad, Catherine, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Harris, Jennifer R., Nilsen, Thomas S., Harden, K. Paige, Tucker-Drob, Elliot M., Franz, Carol E., Kremen, William S., Lyons, Michael J., Lichtenstein, Paul, Jeong, Hoe-Uk, Hur, Yoon-Mi, Boomsma, Dorret I., Sørensen, Thorkild I. A., and Kaprio, Jaakko

Published
2019

13. Genetic and environmental factors affecting birth size variation: a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Author

Yokoyama, Yoshie, primary, Jelenkovic, Aline, additional, Hur, Yoon-Mi, additional, Sund, Reijo, additional, Fagnani, Corrado, additional, Stazi, Maria A, additional, Brescianini, Sonia, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Rebato, Esther, additional, Hopper, John L, additional, Cutler, Tessa L, additional, Saudino, Kimberly J, additional, Nelson, Tracy L, additional, Whitfield, Keith E, additional, Corley, Robin P, additional, Huibregtse, Brooke M, additional, Derom, Catherine A, additional, Vlietinck, Robert F, additional, Loos, Ruth J F, additional, Llewellyn, Clare H, additional, Fisher, Abigail, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Krueger, Robert F, additional, McGue, Matt, additional, Pahlen, Shandell, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E M, additional, Willemsen, Gonneke, additional, Harris, Jennifer R, additional, Brandt, Ingunn, additional, Nilsen, Thomas S, additional, Craig, Jeffrey M, additional, Saffery, Richard, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Haworth, Claire M A, additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Rasmussen, Finn, additional, Tynelius, Per, additional, Tarnoki, Adam D, additional, Tarnoki, David L, additional, Ooki, Syuichi, additional, Rose, Richard J, additional, Pietiläinen, Kirsi H, additional, Sørensen, Thorkild I A, additional, Boomsma, Dorret I, additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2018
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14. Associations between birth size and later height from infancy through adulthood: An individual based pooled analysis of 28 twin cohorts participating in the CODATwins project

Author

Jelenkovic, Aline, primary, Yokoyama, Yoshie, additional, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Ooki, Syuichi, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik K.E., additional, Saudino, Kimberly J., additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, Brescianini, Sonia, additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Cutler, Tessa L., additional, Hopper, John L., additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Alexandra Burt, S., additional, Klump, Kelly L., additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveld, Catharina E.M., additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Rasmussen, Finn, additional, Tynelius, Per, additional, Heikkilä, Kauko, additional, Pietiläinen, Kirsi H., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Haworth, Claire M.A., additional, Plomin, Robert, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Kim, Jina, additional, Lee, Jooyeon, additional, Lee, Sooji, additional, Sung, Joohon, additional, Loos, Ruth J.F., additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I.A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2018
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15. Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Hur, Yoon-Mi, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Magnusson, Patrik KE, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, Beijsterveldt, Catharina EM van, additional, Bogl, Leonie H., additional, Pietiläinen, Kirsi H, additional, Vuoksimaa, Eero, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Nelson, Tracy L, additional, Whitfield, Keith E., additional, Rebato, Esther, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Ooki, Syuichi, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, Brescianini, Sonia, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Cutler, Tessa L, additional, Hopper, John L., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Haworth, Claire MA, additional, Plomin, Robert, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S Alexandra, additional, Klump, Kelly L., additional, Vlietinck, Robert F., additional, Derom, Catherine A., additional, Loos, Ruth JF, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2018
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16. Associations Between Birth Size and Later Height From Infancy Through Adulthood: an Individual Based Pooled Analysis of 28 Twin Cohorts Participating in the Codatwins Project

Author

Fisiología, Fisiologia, Jelenkovic Moreno, Aline, Yokoyama, Yoshie, Sund, Reijo, Hur, Yoon-Mi, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas Sevenius, Ooki, Syuichi, Ullemar, Vilhelmina, Almqvisth, Catarina, Magnusson, Patrik K. E., Saudino, Kimberly J., Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Nelson, Tracy L., Whitfield, Keith E., Knafo Noam, Ariel, Mankuta, David, Abramson, Lior, Cutler, Tessa L., Hopper, John L., Llewellyn, Clare H., Fisher, Abigail, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Bjerregaard Andersen, Morten, Nielsen, Henning Beck, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Burt, S. Alexandra, Klump, Kelly L., Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveld, Catharina E. M., Craig, Jeffrey M., Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Heikkila, Kauko, Pietilainen, Kirsi H., Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire M. A., Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato Ochoa, Esther Matilde, Tarnoki, Adam D., Tarnoki, David L., Kim, Jina, Lee, Jooyeon, Lee, Sooji, Sung, Joohon, Loos, Ruth J. F., Boomsma, Dorret I., Sorensen, Thorkild I. A., Kaprio, Jaakko, Silventoinen, Karri, Fisiología, Fisiologia, Jelenkovic Moreno, Aline, Yokoyama, Yoshie, Sund, Reijo, Hur, Yoon-Mi, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas Sevenius, Ooki, Syuichi, Ullemar, Vilhelmina, Almqvisth, Catarina, Magnusson, Patrik K. E., Saudino, Kimberly J., Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Nelson, Tracy L., Whitfield, Keith E., Knafo Noam, Ariel, Mankuta, David, Abramson, Lior, Cutler, Tessa L., Hopper, John L., Llewellyn, Clare H., Fisher, Abigail, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Bjerregaard Andersen, Morten, Nielsen, Henning Beck, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Burt, S. Alexandra, Klump, Kelly L., Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveld, Catharina E. M., Craig, Jeffrey M., Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Heikkila, Kauko, Pietilainen, Kirsi H., Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire M. A., Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato Ochoa, Esther Matilde, Tarnoki, Adam D., Tarnoki, David L., Kim, Jina, Lee, Jooyeon, Lee, Sooji, Sung, Joohon, Loos, Ruth J. F., Boomsma, Dorret I., Sorensen, Thorkild I. A., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Background: There is evidence that birth size is positively associated with height in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. Aim: To analyze the associations of birth weight, length and ponderal index with height from infancy through adulthood within mono- and dizygotic twin pairs, which provides insights into the role of genetic and environmental individual-specific factors. Methods: This study is based on the data from 28 twin cohorts in 17 countries. The pooled data included 41,852 complete twin pairs (55% monozygotic and 45% same-sex dizygotic) with information on birth weight and a total of 112,409 paired height measurements at ages ranging from 1 to 69 years. Birth length was available for 19,881 complete twin pairs, with a total of 72,692 paired height measurements. The association between birth size and later height was analyzed at both the individual and within-pair level by linear regression analyses. Results: Within twin pairs, regression coefficients showed that a 1-kg increase in birth weight and a 1-cm increase in birth length were associated with 1.14-4.25 cm and 0.18-0.90 cm taller height, respectively. The magnitude of the associations was generally greater within dizygotic than within monozygotic twin pairs, and this difference between zygosities was more pronounced for birth length. Conclusion: Both genetic and individual-specific environmental factors play a role in the association between birth size and later height from infancy to adulthood, with a larger role for genetics in the association with birth length than with birth weight.

Published
2018

17. Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individualbased pooled analysis of 21 cohorts

Author

Fisiología, Fisiologia, Jelenkovic Moreno, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina EM, Bogl, Leonie H, Pietiläinen, Kirsi H, Vuoksimaa, Eero, Ji, Fuling, Ning, Feng, Pang, Zengchang, Nelson, Tracy L, Whitfield, Keith E., Rebato Ochoa, Esther Matilde, Llewellyn, Clare H., Fisher, Abigail, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Cutler, Tessa L., Hopper, John L., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Craig, Jeffrey M., Saffery, Richard, Haworth, Claire MA, Fisiología, Fisiologia, Jelenkovic Moreno, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina EM, Bogl, Leonie H, Pietiläinen, Kirsi H, Vuoksimaa, Eero, Ji, Fuling, Ning, Feng, Pang, Zengchang, Nelson, Tracy L, Whitfield, Keith E., Rebato Ochoa, Esther Matilde, Llewellyn, Clare H., Fisher, Abigail, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Cutler, Tessa L., Hopper, John L., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Craig, Jeffrey M., Saffery, Richard, and Haworth, Claire MA

Abstract

It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95%Cl 18 to 45) heavier and 0.16 cm (95%CI 0.045 to 0.274) longer than those with a co-twin brother. In girls, birth size was not associated (5 g birth weight; 95%Cl -8 to -18 and -0.089 cm birth length; 95% CI -0.202 to 0.025) with the sex of the co-twin. Gestational age was slightly shorter in boy-boy pairs than in boy-girl and girl-girl pairs. When birth size was standardized by gestational age, the magnitude of the associations was attenuated in boys, particularly for birth weight. In conclusion, boys with a co-twin sister are heavier and longer at birth than those with a co-twin brother. However, these differences are modest and partly explained by a longer gestation in the presence of a co-twin sister.

Published
2018

18. Genetic and environmental factors affecting birth size variation: A pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Author

Yokoyama, Yoshie, Jelenkovic, Aline, Hur, Yoon Mi, Sund, Reijo, Fagnani, Corrado, Stazi, Maria A., Brescianini, Sonia, Ji, Fuling, Ning, Feng, Pang, Zengchang, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Rebato, Esther, Hopper, John L., Cutler, Tessa L., Saudino, Kimberly J., Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J.F., Llewellyn, Clare H., Fisher, Abigail, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Bartels, Meike, Van Beijsterveldt, Catharina E.M., Willemsen, Gonneke, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Haworth, Claire M.A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Rasmussen, Finn, Tynelius, Per, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Rose, Richard J., Pietiläinen, Kirsi H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Yokoyama, Yoshie, Jelenkovic, Aline, Hur, Yoon Mi, Sund, Reijo, Fagnani, Corrado, Stazi, Maria A., Brescianini, Sonia, Ji, Fuling, Ning, Feng, Pang, Zengchang, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Rebato, Esther, Hopper, John L., Cutler, Tessa L., Saudino, Kimberly J., Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J.F., Llewellyn, Clare H., Fisher, Abigail, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Bartels, Meike, Van Beijsterveldt, Catharina E.M., Willemsen, Gonneke, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Haworth, Claire M.A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Rasmussen, Finn, Tynelius, Per, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Rose, Richard J., Pietiläinen, Kirsi H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Background: The genetic architecture of birth size may differ geographically and over time. We examined differences in the genetic and environmental contributions to birthweight, length and ponderal index (PI) across geographical-cultural regions (Europe, North America and Australia, and East Asia) and across birth cohorts, and how gestational age modifies these effects. Methods: Data from 26 twin cohorts in 16 countries including 57 613 monozygotic and dizygotic twin pairs were pooled. Genetic and environmental variations of birth size were estimated using genetic structural equation modelling. Results: The variance of birthweight and length was predominantly explained by shared environmental factors, whereas the variance of PI was explained both by shared and unique environmental factors. Genetic variance contributing to birth size was small. Adjusting for gestational age decreased the proportions of shared environmental variance and increased the propositions of unique environmental variance. Genetic variance was similar in the geographical-cultural regions, but shared environmental variance was smaller in East Asia than in Europe and North America and Australia. The total variance and shared environmental variance of birth length and PI were greater from the birth cohort 1990-99 onwards compared with the birth cohorts from 1970-79 to 1980-89. Conclusions: The contribution of genetic factors to birth size is smaller than that of shared environmental factors, which is partly explained by gestational age. Shared environmental variances of birth length and PI were greater in the latest birth cohorts and differed also across geographical-cultural regions. Shared environmental factors are important when explaining differences in the variation of birth size globally and over time.

Published
2018
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19. Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrick K. E., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Bogl, Leonie H., Pietiläinen, Kirsi H., Vuoksimaa, Eero, Ji, Fuling, Ning, Feng Ning, Pang, Zengchang, Nelson, Tracy L., Whitfield, Keith E., Rebato, Esther, Craig, Jeffrey M., Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrick K. E., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Bogl, Leonie H., Pietiläinen, Kirsi H., Vuoksimaa, Eero, Ji, Fuling, Ning, Feng Ning, Pang, Zengchang, Nelson, Tracy L., Whitfield, Keith E., Rebato, Esther, and Craig, Jeffrey M.

Abstract

It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95% CI 18 to 45) heavier and 0.16 cm (95% CI 0.045 to 0.274) longer than those with a co-twin brother. In girls, birth size was not associated (5 g birth weight; 95% CI −8 to −18 and −0.089 cm birth length; 95% CI −0.202 to 0.025) with the sex of the co-twin. Gestational age was slightly shorter in boy-boy pairs than in boy-girl and girl-girl pairs. When birth size was standardized by gestational age, the magnitude of the associations was attenuated in boys, particularly for birth weight. In conclusion, boys with a co-twin sister are heavier and longer at birth than those with a co-twin brother. However, these differences are modest and partly explained by a longer gestation in the presence of a co-twin sister.

Published
2018

20. Genetic and environmental factors affecting birth size variation:a pooled individual-based analysis of secular trends and global geographical differences using 26 twin cohorts

Author

Yokoyama, Yoshie, Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Fagnani, Corrado, Stazi, Maria A., Brescianini, Sonia, Ji, Fuling, Ning, Feng, Pang, Zengchang, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Rebato, Esther, Hopper, John L., Cutler, Tessa L., Saudino, Kimberly J., Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Llewellyn, Clare H., Fisher, Abigail, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Bartels, Meike, van Beijsterveldt, Catharina E. M., Willemsen, Gonneke, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Rasmussen, Finn, Tynelius, Per, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Rose, Richard J., Pietilainen, Kirsi H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Yokoyama, Yoshie, Jelenkovic, Aline, Hur, Yoon-Mi, Sund, Reijo, Fagnani, Corrado, Stazi, Maria A., Brescianini, Sonia, Ji, Fuling, Ning, Feng, Pang, Zengchang, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Rebato, Esther, Hopper, John L., Cutler, Tessa L., Saudino, Kimberly J., Nelson, Tracy L., Whitfield, Keith E., Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Llewellyn, Clare H., Fisher, Abigail, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Bartels, Meike, van Beijsterveldt, Catharina E. M., Willemsen, Gonneke, Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Rasmussen, Finn, Tynelius, Per, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Rose, Richard J., Pietilainen, Kirsi H., Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Published
2018

21. Birth size and gestational age in opposite-sex twins as compared to same-sex twins:An individual-based pooled analysis of 21 cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Bogl, Leonie H., Pietilainen, Kirsi H., Vuoksimaa, Eero, Ji, Fuling, Ning, Feng, Pang, Zengchang, Nelson, Tracy L., Whitfield, Keith E., Rebato, Esther, Llewellyn, Clare H., Fisher, Abigail, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Cutler, Tessa L., Hopper, John L., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Craig, Jeffrey M., Saffery, Richard, Haworth, Claire M. A., Plomin, Robert, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Vlietinck, Robert F., Derom, Catherine A., Loos, Ruth J. F., Boomsma, Dorret I., Sorensen, Thorkild I.A., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Yokoyama, Yoshie, Hur, Yoon-Mi, Ullemar, Vilhelmina, Almqvist, Catarina, Magnusson, Patrik K. E., Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Catharina E. M., Bogl, Leonie H., Pietilainen, Kirsi H., Vuoksimaa, Eero, Ji, Fuling, Ning, Feng, Pang, Zengchang, Nelson, Tracy L., Whitfield, Keith E., Rebato, Esther, Llewellyn, Clare H., Fisher, Abigail, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Ooki, Syuichi, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Cutler, Tessa L., Hopper, John L., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Craig, Jeffrey M., Saffery, Richard, Haworth, Claire M. A., Plomin, Robert, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Vlietinck, Robert F., Derom, Catherine A., Loos, Ruth J. F., Boomsma, Dorret I., Sorensen, Thorkild I.A., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

It is well established that boys are born heavier and longer than girls, but it remains unclear whether birth size in twins is affected by the sex of their co-twin. We conducted an individual-based pooled analysis of 21 twin cohorts in 15 countries derived from the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), including 67,850 dizygotic twin individuals. Linear regression analyses showed that boys having a co-twin sister were, on average, 31 g (95% CI 18 to 45) heavier and 0.16 cm (95% CI 0.045 to 0.274) longer than those with a co-twin brother. In girls, birth size was not associated (5 g birth weight; 95% CI -8 to -18 and -0.089 cm birth length; 95% CI -0.202 to 0.025) with the sex of the co-twin. Gestational age was slightly shorter in boy-boy pairs than in boy-girl and girl-girl pairs. When birth size was standardized by gestational age, the magnitude of the associations was attenuated in boys, particularly for birth weight. In conclusion, boys with a co-twin sister are heavier and longer at birth than those with a co-twin brother. However, these differences are modest and partly explained by a longer gestation in the presence of a co-twin sister.

Published
2018

22. Genetic And Environmental Effects On Body Mass Index From Infancy To The Onset Of Adulthood: An Individual-Based Pooled Analysis Of 45 Twin Cohorts Participating In The Collaborative Project Of Development Of Anthropometrical Measures In Twins (Codatwins) Study

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Moller, Soren, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, and Hwang, Amie E.

Abstract

Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking.

Published
2016

23. Genetic And Environmental Influences On Height From Infancy To Early Adulthood: An Individual-Based Pooled Analysis Of 45 Twin Cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, and Rebato, Esther

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

24. Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Latvala, Antti, additional, Sund, Reijo, additional, Yokoyama, Yoshie, additional, Ullemar, Vilhelmina, additional, Almqvist, Catarina, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Kandler, Christian, additional, Honda, Chika, additional, Inui, Fujio, additional, Iwatani, Yoshinori, additional, Watanabe, Mikio, additional, Rebato, Esther, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, Brescianini, Sonia, additional, Hur, Yoon-Mi, additional, Jeong, Hoe-Uk, additional, Cutler, Tessa L., additional, Hopper, John L., additional, Busjahn, Andreas, additional, Saudino, Kimberly J., additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rose, Richard J., additional, Koskenvuo, Markku, additional, Heikkilä, Kauko, additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Sung, Joohon, additional, Kim, Jina, additional, Lee, Jooyeon, additional, Lee, Sooji, additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Medland, Sarah E., additional, Martin, Nicholas G., additional, Montgomery, Grant W., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Dahl Aslan, Anna K., additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Catharina E. M., additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas S., additional, Rasmussen, Finn, additional, Tynelius, Per, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Gatz, Margaret, additional, Butler, David A., additional, Lichtenstein, Paul, additional, Goldberg, Jack H., additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Maia, José A., additional, Freitas, Duarte L., additional, Turkheimer, Eric, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, and Kaprio, Jaakko, additional

Published
2017
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25. Education in twins and their parents across birth cohorts over 100 years : an individual-level pooled analysis of 42 twin cohorts

Author

Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Sund, Reijo, Yokoyama, Yoshie, Ullemar, Vilhelmina, Almqvist, Catarina, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Kandler, Christian, Honda, Chika, Inui, Fujio, Iwatani, Yoshinori, Watanabe, Mikio, Rebato, Esther, Stazi, Maria A, Fagnani, Corrado, Brescianini, Sonia, Hur, Yoon-Mi, Jeong, Hoe-Uk, Cutler, Tessa L, Hopper, John L, Busjahn, Andreas, Saudino, Kimberly J, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rose, Richard J, Koskenvuo, Markku, Heikkilae, Kauko, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling V, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Nelson, Tracy L, Whitfield, Keith E, Tan, Qihua, Zhang, Dongfeng, Llewellyn, Clare H, Fisher, Abigail, Burt, S Alexandra, Klump, Kelly L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Medland, Sarah E, Martin, Nicholas G, Montgomery, Grant W, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Corley, Robin P, Huibregtse, Brooke M, OEncel, Sevgi Y, Aliev, Fazil, Krueger, Robert F, Mcgue, Matt, Pahlen, Shandell, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina E M, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas S, Rasmussen, Finn, Tynelius, Per, Baker, Laura A, Tuvblad, Catherine, Ordonana, Juan R, Sanchez-Romera, Juan F, Colodro-Conde, Lucia, Gatz, Margaret, Butler, David A, Lichtenstein, Paul, Goldberg, Jack H, Harden, K Paige, Tucker-Drob, Elliot M, Duncan, Glen E, Buchwald, Dedra, Tarnoki, Adam D, Tarnoki, David L, Franz, Carol E, Kremen, William S, Lyons, Michael J, Maia, Jose A, Freitas, Duarte L, Turkheimer, Eric, Sorensen, Thorkild I A, Boomsma, Dorret I, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Sund, Reijo, Yokoyama, Yoshie, Ullemar, Vilhelmina, Almqvist, Catarina, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Kandler, Christian, Honda, Chika, Inui, Fujio, Iwatani, Yoshinori, Watanabe, Mikio, Rebato, Esther, Stazi, Maria A, Fagnani, Corrado, Brescianini, Sonia, Hur, Yoon-Mi, Jeong, Hoe-Uk, Cutler, Tessa L, Hopper, John L, Busjahn, Andreas, Saudino, Kimberly J, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rose, Richard J, Koskenvuo, Markku, Heikkilae, Kauko, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling V, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Nelson, Tracy L, Whitfield, Keith E, Tan, Qihua, Zhang, Dongfeng, Llewellyn, Clare H, Fisher, Abigail, Burt, S Alexandra, Klump, Kelly L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Medland, Sarah E, Martin, Nicholas G, Montgomery, Grant W, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Corley, Robin P, Huibregtse, Brooke M, OEncel, Sevgi Y, Aliev, Fazil, Krueger, Robert F, Mcgue, Matt, Pahlen, Shandell, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina E M, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas S, Rasmussen, Finn, Tynelius, Per, Baker, Laura A, Tuvblad, Catherine, Ordonana, Juan R, Sanchez-Romera, Juan F, Colodro-Conde, Lucia, Gatz, Margaret, Butler, David A, Lichtenstein, Paul, Goldberg, Jack H, Harden, K Paige, Tucker-Drob, Elliot M, Duncan, Glen E, Buchwald, Dedra, Tarnoki, Adam D, Tarnoki, David L, Franz, Carol E, Kremen, William S, Lyons, Michael J, Maia, Jose A, Freitas, Duarte L, Turkheimer, Eric, Sorensen, Thorkild I A, Boomsma, Dorret I, and Kaprio, Jaakko

Abstract

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990-1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

Published
2017

26. Education in Twins and Their Parents Across Birth Cohorts Over 100 years:An Individual-Level Pooled Analysis of 42-Twin Cohorts

Author

Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Sund, Reijo, Yokoyama, Yoshie, Ullemar, Vilhelmina, Almqvist, Catarina, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Kandler, Christian, Honda, Chika, Inui, Fujio, Iwatani, Yoshinori, Watanabe, Mikio, Rebato, Esther, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Hur, Yoon-Mi, Jeong, Hoe-Uk, Cutler, Tessa L., Hopper, John L., Busjahn, Andreas, Saudino, Kimberly J., Ji, Fuling, Ning, Feng, Pang, Zengchang, Rose, Richard J., Koskenvuo, Markku, Heikkilae, Kauko, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Nelson, Tracy L., Whitfield, Keith E., Tan, Qihua, Zhang, Dongfeng, Llewellyn, Clare H., Fisher, Abigail, Burt, S. Alexandra, Klump, Kelly L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Medland, Sarah E., Martin, Nicholas G., Montgomery, Grant W., Magnusson, Patrik K. E., Pedersen, Nancy L., Aslan, Anna K. Dahl, Corley, Robin P., Huibregtse, Brooke M., OEncel, Sevgi Y., Aliev, Fazil, Krueger, Robert F., Mcgue, Matt, Pahlen, Shandell, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina E. M., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Rasmussen, Finn, Tynelius, Per, Baker, Laura A., Tuvblad, Catherine, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Gatz, Margaret, Butler, David A., Lichtenstein, Paul, Goldberg, Jack H., Harden, K. Paige, Tucker-Drob, Elliot M., Duncan, Glen E., Buchwald, Dedra, Tarnoki, Adam D., Tarnoki, David L., Franz, Carol E., Kremen, William S., Lyons, Michael J., Maia, Jose A., Freitas, Duarte L., Turkheimer, Eric, Sørensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Latvala, Antti, Sund, Reijo, Yokoyama, Yoshie, Ullemar, Vilhelmina, Almqvist, Catarina, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Kandler, Christian, Honda, Chika, Inui, Fujio, Iwatani, Yoshinori, Watanabe, Mikio, Rebato, Esther, Stazi, Maria A., Fagnani, Corrado, Brescianini, Sonia, Hur, Yoon-Mi, Jeong, Hoe-Uk, Cutler, Tessa L., Hopper, John L., Busjahn, Andreas, Saudino, Kimberly J., Ji, Fuling, Ning, Feng, Pang, Zengchang, Rose, Richard J., Koskenvuo, Markku, Heikkilae, Kauko, Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Siribaddana, Sisira H., Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Sung, Joohon, Kim, Jina, Lee, Jooyeon, Lee, Sooji, Nelson, Tracy L., Whitfield, Keith E., Tan, Qihua, Zhang, Dongfeng, Llewellyn, Clare H., Fisher, Abigail, Burt, S. Alexandra, Klump, Kelly L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Medland, Sarah E., Martin, Nicholas G., Montgomery, Grant W., Magnusson, Patrik K. E., Pedersen, Nancy L., Aslan, Anna K. Dahl, Corley, Robin P., Huibregtse, Brooke M., OEncel, Sevgi Y., Aliev, Fazil, Krueger, Robert F., Mcgue, Matt, Pahlen, Shandell, Willemsen, Gonneke, Bartels, Meike, Van Beijsterveldt, Catharina E. M., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Harris, Jennifer R., Brandt, Ingunn, Nilsen, Thomas S., Rasmussen, Finn, Tynelius, Per, Baker, Laura A., Tuvblad, Catherine, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Gatz, Margaret, Butler, David A., Lichtenstein, Paul, Goldberg, Jack H., Harden, K. Paige, Tucker-Drob, Elliot M., Duncan, Glen E., Buchwald, Dedra, Tarnoki, Adam D., Tarnoki, David L., Franz, Carol E., Kremen, William S., Lyons, Michael J., Maia, Jose A., Freitas, Duarte L., Turkheimer, Eric, Sørensen, Thorkild I. A., Boomsma, Dorret I., and Kaprio, Jaakko

Abstract

Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.

Published
2017

27. Association between birthweight and later body mass index:an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H, Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos Cem, Ooki, Syuichi, Saudino, Kimberly J, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Nelson, Tracy L, Whitfield, Keith E, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L, Hopper, John L, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth Jf, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire Ma, Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I, Sørensen, Thorkild Ia, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Pietiläinen, Kirsi H, Hur, Yoon-Mi, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos Cem, Ooki, Syuichi, Saudino, Kimberly J, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Nelson, Tracy L, Whitfield, Keith E, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Heikkilä, Kauko, Cutler, Tessa L, Hopper, John L, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Corley, Robin P, Huibregtse, Brooke M, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth Jf, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D, Tarnoki, David L, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Rasmussen, Finn, Tynelius, Per, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Haworth, Claire Ma, Plomin, Robert, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Boomsma, Dorret I, Sørensen, Thorkild Ia, Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Background: There is evidence that birthweight is positively associated with body mass index (BMI) in later life, but it remains unclear whether this is explained by genetic factors or the intrauterine environment. We analysed the association between birthweight and BMI from infancy to adulthood within twin pairs, which provides insights into the role of genetic and environmental individual-specific factors.Methods: This study is based on the data from 27 twin cohorts in 17 countries. The pooled data included 78 642 twin individuals (20 635 monozygotic and 18 686 same-sex dizygotic twin pairs) with information on birthweight and a total of 214 930 BMI measurements at ages ranging from 1 to 49 years. The association between birthweight and BMI was analysed at both the individual and within-pair levels using linear regression analyses.Results: At the individual level, a 1-kg increase in birthweight was linearly associated with up to 0.9 kg/m 2 higher BMI ( P < 0.001). Within twin pairs, regression coefficients were generally greater (up to 1.2 kg/m 2 per kg birthweight, P < 0.001) than those from the individual-level analyses. Intra-pair associations between birthweight and later BMI were similar in both zygosity groups and sexes and were lower in adulthood.Conclusions: These findings indicate that environmental factors unique to each individual have an important role in the positive association between birthweight and later BMI, at least until young adulthood.

Published
2017

28. The Codatwins Project: The Cohort Description Of Collaborative Project Of Development Of Anthropometrical Measures In Twins To Study Macro-Environmental Variation In Genetic And Environmental Effects On Anthropometric Traits

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D., Tarnoki, David L., Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Burt, S. Alexandra, Klump, Kelly L., Medland, Sarah E., Montgomery, Grant W., Kandler, Christian, and McAdams, Tom A.

Abstract

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m(2)) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

Published
2015

29. Zygosity Differences In Height And Body Mass Index Of Twins From Infancy To Old Age: A Study Of The Codatwins Project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H., Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordonana, Juan R., Sanchez-Romera, Juan F., Colodro-Conde, Lucia, Burt, S. Alexandra, Klump, Kelly L., Medland, Sarah E., Montgomery, Grant W., Kandler, Christian, McAdams, Tom A., Eley, Thalia C., and Gregory, Alice M.

Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m(2) in childhood and adolescence and up to 0.2 kg/m(2) in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Published
2015

30. Genetic and environmental influences on height from infancy to early adulthood

Author

University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sorensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, University of Helsinki, Department of Social Research, University of Helsinki, Department of Public Health, University of Helsinki, Clinicum, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Moller, Soren, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sorensen, Thorkild I. A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1-19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

31. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age:A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Author

Yokoyama, Yoshie, Jelenkovic, Aline, Sund, Reijo, Sung, Joohon, Hopper, John L, Ooki, Syuichi, Heikkilä, Kauko, Aaltonen, Sari, Tarnoki, Adam D, Tarnoki, David L, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos C E M, Saudino, Kimberly J, Cutler, Tessa L, Nelson, Tracy L, Whitfield, Keith E, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Jeong, Hoe-Uk, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Ji, Fuling, Ning, Feng, Pang, Zengchang, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Tynelius, Per, Haworth, Claire M A, Plomin, Robert, Rebato, Esther, Rose, Richard J, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Sørensen, Thorkild I A, Boomsma, Dorret I, Kaprio, Jaakko, Silventoinen, Karri, Yokoyama, Yoshie, Jelenkovic, Aline, Sund, Reijo, Sung, Joohon, Hopper, John L, Ooki, Syuichi, Heikkilä, Kauko, Aaltonen, Sari, Tarnoki, Adam D, Tarnoki, David L, Willemsen, Gonneke, Bartels, Meike, van Beijsterveldt, Toos C E M, Saudino, Kimberly J, Cutler, Tessa L, Nelson, Tracy L, Whitfield, Keith E, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Jeong, Hoe-Uk, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S Alexandra, Klump, Kelly L, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Harris, Jennifer R, Brandt, Ingunn, Nilsen, Thomas Sevenius, Craig, Jeffrey M, Saffery, Richard, Ji, Fuling, Ning, Feng, Pang, Zengchang, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Tynelius, Per, Haworth, Claire M A, Plomin, Robert, Rebato, Esther, Rose, Richard J, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Sørensen, Thorkild I A, Boomsma, Dorret I, Kaprio, Jaakko, and Silventoinen, Karri

Abstract

We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.

Published
2016

32. Genetic and environmental effects on body mass index from infancy to the onset of adulthood:an individual-based pooled analysis of 45 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) study

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Møller, Søren, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, Jose Antonio, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Oncel, Sevgi Y., Aliev, Fazil, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Honda, Chika, Hjelmborg, Jacob vB, Møller, Søren, Ooki, Syuichi, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Freitas, Duarte L., Maia, Jose Antonio, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Chong, Youngsook, Swan, Gary E., Krasnow, Ruth, Magnusson, Patrik K. E., Pedersen, Nancy L., Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Oncel, Sevgi Y., Aliev, Fazil, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., and Kaprio, Jaakko

Abstract

Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different e, Background: Both genetic and environmental factors are known to affect body mass index (BMI), but detailed understanding of how their effects differ during childhood and adolescence is lacking. Objectives: We analyzed the genetic and environmental contributions to BMI variation from infancy to early adulthood and the ways they differ by sex and geographic regions representing high (North America and Australia), moderate (Europe), and low levels (East Asia) of obesogenic environments. Design: Data were available for 87,782 complete twin pairs from 0.5 to 19.5 y of age from 45 cohorts. Analyses were based on 383,092 BMI measurements. Variation in BMI was decomposed into genetic and environmental components through genetic structural equation modeling. Results: The variance of BMI increased from 5 y of age along with increasing mean BMI. The proportion of BMI variation explained by additive genetic factors was lowest at 4 y of age in boys (a2 = 0.42) and girls (a2 = 0.41) and then generally increased to 0.75 in both sexes at 19 y of age. This was because of a stronger influence of environmental factors shared by co-twins in midchildhood. After 15 y of age, the effect of shared environment was not observed. The sex-specific expression of genetic factors was seen in infancy but was most prominent at 13 y of age and older. The variance of BMI was highest in North America and Australia and lowest in East Asia, but the relative proportion of genetic variation to total variation remained roughly similar across different regions. Conclusions: Environmental factors shared by co-twins affect BMI in childhood, but little evidence for their contribution was found in late adolescence. Our results suggest that genetic factors play a major role in the variation of BMI in adolescence among populations of different ethnicities exposed to different environmental factors related to obesity.

Published
2016

33. Genetic and environmental influences on height from infancy to early adulthood:An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Möller, Sören, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Hur, Yoon-Mi, Yokoyama, Yoshie, Hjelmborg, Jacob V. B., Möller, Sören, Honda, Chika, Magnusson, Patrik K. E., Pedersen, Nancy L., Ooki, Syuichi, Aaltonen, Sari, Stazi, Maria A., Fagnani, Corrado, D'Ippolito, Cristina, Freitas, Duarte L., Maia, Jose Antonio, Ji, Fuling, Ning, Feng, Pang, Zengchang, Rebato, Esther, Busjahn, Andreas, Kandler, Christian, Saudino, Kimberly J., Jang, Kerry L., Cozen, Wendy, Hwang, Amie E., Mack, Thomas M., Gao, Wenjing, Yu, Canqing, Li, Liming, Corley, Robin P., Huibregtse, Brooke M., Derom, Catherine A., Vlietinck, Robert F., Loos, Ruth J. F., Heikkila, Kauko, Wardle, Jane, Llewellyn, Clare H., Fisher, Abigail, McAdams, Tom A., Eley, Thalia C., Gregory, Alice M., He, Mingguang, Ding, Xiaohu, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Tarnoki, Adam D., Tarnoki, David L., Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Burt, S. Alexandra, Klump, Kelly L., Silberg, Judy L., Eaves, Lindon J., Maes, Hermine H., Krueger, Robert F., McGue, Matt, Pahlen, Shandell, Gatz, Margaret, Butler, David A., Bartels, Meike, van Beijsterveldt, Toos C. E. M., Craig, Jeffrey M., Saffery, Richard, Dubois, Lise, Boivin, Michel, Brendgen, Mara, Dionne, Ginette, Vitaro, Frank, Martin, Nicholas G., Medland, Sarah E., Montgomery, Grant W., Swan, Gary E., Krasnow, Ruth, Tynelius, Per, Lichtenstein, Paul, Haworth, Claire M. A., Plomin, Robert, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Harden, K. Paige, Tucker-Drob, Elliot M., Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Baker, Laura A., Tuvblad, Catherine, Duncan, Glen E., Buchwald, Dedra, Willemsen, Gonneke, Skytthe, Axel, Kyvik, Kirsten O., Christensen, Kaare, Oncel, Sevgi Y., Aliev, Fazil, Rasmussen, Finn, Goldberg, Jack H., Sørensen, Thorkild I.A., Boomsma, Dorret I., Kaprio, Jaakko, and Silventoinen, Karri

Abstract

Height variation is known to be determined by both genetic and environmental factors, but a systematic description of how their influences differ by sex, age and global regions is lacking. We conducted an individual-based pooled analysis of 45 twin cohorts from 20 countries, including 180,520 paired measurements at ages 1–19 years. The proportion of height variation explained by shared environmental factors was greatest in early childhood, but these effects remained present until early adulthood. Accordingly, the relative genetic contribution increased with age and was greatest in adolescence (up to 0.83 in boys and 0.76 in girls). Comparing geographic-cultural regions (Europe, North-America and Australia, and East-Asia), genetic variance was greatest in North-America and Australia and lowest in East-Asia, but the relative proportion of genetic variation was roughly similar across these regions. Our findings provide further insights into height variation during childhood and adolescence in populations representing different ethnicities and exposed to different environments.

Published
2016

34. Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts

Author

Jelenkovic, Aline, primary, Sund, Reijo, additional, Hur, Yoon-Mi, additional, Yokoyama, Yoshie, additional, Hjelmborg, Jacob v. B., additional, Möller, Sören, additional, Honda, Chika, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Ooki, Syuichi, additional, Aaltonen, Sari, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Rebato, Esther, additional, Busjahn, Andreas, additional, Kandler, Christian, additional, Saudino, Kimberly J., additional, Jang, Kerry L., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, Gao, Wenjing, additional, Yu, Canqing, additional, Li, Liming, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Heikkilä, Kauko, additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Gatz, Margaret, additional, Butler, David A., additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Tynelius, Per, additional, Lichtenstein, Paul, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Willemsen, Gonneke, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Christensen, Kaare, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Rasmussen, Finn, additional, Goldberg, Jack H., additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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35. Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project

Author

Yokoyama, Yoshie, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Sung, Joohon, additional, Hopper, John L., additional, Ooki, Syuichi, additional, Heikkilä, Kauko, additional, Aaltonen, Sari, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Willemsen, Gonneke, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Saudino, Kimberly J., additional, Cutler, Tessa L., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, He, Mingguang, additional, Ding, Xiaohu, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Jeong, Hoe-Uk, additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Harris, Jennifer R., additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Dubois, Lise, additional, Boivin, Michel, additional, Brendgen, Mara, additional, Dionne, Ginette, additional, Vitaro, Frank, additional, Martin, Nicholas G., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Tynelius, Per, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Rebato, Esther, additional, Rose, Richard J., additional, Goldberg, Jack H., additional, Rasmussen, Finn, additional, Hur, Yoon-Mi, additional, Sørensen, Thorkild I. A., additional, Boomsma, Dorret I., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2016
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36. The CODATwins Project:The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Author

Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D, Tarnoki, David L, Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Hong, Changhee, Chong, Youngsook, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Rasmussen, Finn, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Boomsma, Dorret I, Hur, Yoon-Mi, Sørensen, Thorkild I A, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Sund, Reijo, Honda, Chika, Aaltonen, Sari, Yokoyama, Yoshie, Tarnoki, Adam D, Tarnoki, David L, Ning, Feng, Ji, Fuling, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Hong, Changhee, Chong, Youngsook, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Rasmussen, Finn, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Boomsma, Dorret I, Hur, Yoon-Mi, Sørensen, Thorkild I A, and Kaprio, Jaakko

Abstract

For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes., For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.

Published
2015

37. Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age:A Study of the CODATwins Project

Author

Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Tarnoki, Adam D, Tarnoki, David L, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Kim, Bia, Chong, Youngsook, Hong, Changhee, Shin, Hyun Jung, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Boomsma, Dorret I, Sørensen, Thorkild I A, Kaprio, Jaakko, Silventoinen, Karri, Jelenkovic, Aline, Yokoyama, Yoshie, Sund, Reijo, Honda, Chika, Bogl, Leonie H, Aaltonen, Sari, Ji, Fuling, Ning, Feng, Pang, Zengchang, Ordoñana, Juan R, Sánchez-Romera, Juan F, Colodro-Conde, Lucia, Burt, S Alexandra, Klump, Kelly L, Medland, Sarah E, Montgomery, Grant W, Kandler, Christian, McAdams, Tom A, Eley, Thalia C, Gregory, Alice M, Saudino, Kimberly J, Dubois, Lise, Boivin, Michel, Tarnoki, Adam D, Tarnoki, David L, Haworth, Claire M A, Plomin, Robert, Öncel, Sevgi Y, Aliev, Fazil, Stazi, Maria A, Fagnani, Corrado, D'Ippolito, Cristina, Craig, Jeffrey M, Saffery, Richard, Siribaddana, Sisira H, Hotopf, Matthew, Sumathipala, Athula, Rijsdijk, Fruhling, Spector, Timothy, Mangino, Massimo, Lachance, Genevieve, Gatz, Margaret, Butler, David A, Bayasgalan, Gombojav, Narandalai, Danshiitsoodol, Freitas, Duarte L, Maia, José Antonio, Harden, K Paige, Tucker-Drob, Elliot M, Kim, Bia, Chong, Youngsook, Hong, Changhee, Shin, Hyun Jung, Christensen, Kaare, Skytthe, Axel, Kyvik, Kirsten O, Derom, Catherine A, Vlietinck, Robert F, Loos, Ruth J F, Cozen, Wendy, Hwang, Amie E, Mack, Thomas M, He, Mingguang, Ding, Xiaohu, Chang, Billy, Silberg, Judy L, Eaves, Lindon J, Maes, Hermine H, Cutler, Tessa L, Hopper, John L, Aujard, Kelly, Magnusson, Patrik K E, Pedersen, Nancy L, Aslan, Anna K Dahl, Song, Yun-Mi, Yang, Sarah, Lee, Kayoung, Baker, Laura A, Tuvblad, Catherine, Bjerregaard-Andersen, Morten, Beck-Nielsen, Henning, Sodemann, Morten, Heikkilä, Kauko, Tan, Qihua, Zhang, Dongfeng, Swan, Gary E, Krasnow, Ruth, Jang, Kerry L, Knafo-Noam, Ariel, Mankuta, David, Abramson, Lior, Lichtenstein, Paul, Krueger, Robert F, McGue, Matt, Pahlen, Shandell, Tynelius, Per, Duncan, Glen E, Buchwald, Dedra, Corley, Robin P, Huibregtse, Brooke M, Nelson, Tracy L, Whitfield, Keith E, Franz, Carol E, Kremen, William S, Lyons, Michael J, Ooki, Syuichi, Brandt, Ingunn, Nilsen, Thomas Sevenius, Inui, Fujio, Watanabe, Mikio, Bartels, Meike, van Beijsterveldt, Toos C E M, Wardle, Jane, Llewellyn, Clare H, Fisher, Abigail, Rebato, Esther, Martin, Nicholas G, Iwatani, Yoshinori, Hayakawa, Kazuo, Sung, Joohon, Harris, Jennifer R, Willemsen, Gonneke, Busjahn, Andreas, Goldberg, Jack H, Rasmussen, Finn, Hur, Yoon-Mi, Boomsma, Dorret I, Sørensen, Thorkild I A, Kaprio, Jaakko, and Silventoinen, Karri

Abstract

A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.

Published
2015

38. Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project

Author

Jelenkovic, Aline, primary, Yokoyama, Yoshie, additional, Sund, Reijo, additional, Honda, Chika, additional, Bogl, Leonie H, additional, Aaltonen, Sari, additional, Ji, Fuling, additional, Ning, Feng, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Rijsdijk, Fruhling, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L, additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Kim, Bia, additional, Chong, Youngsook, additional, Hong, Changhee, additional, Shin, Hyun Jung, additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Rasmussen, Finn, additional, Hur, Yoon-Mi, additional, Boomsma, Dorret I., additional, Sørensen, Thorkild I. A., additional, Kaprio, Jaakko, additional, and Silventoinen, Karri, additional

Published
2015
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39. The CODATwins Project: The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits

Author

Silventoinen, Karri, primary, Jelenkovic, Aline, additional, Sund, Reijo, additional, Honda, Chika, additional, Aaltonen, Sari, additional, Yokoyama, Yoshie, additional, Tarnoki, Adam D., additional, Tarnoki, David L., additional, Ning, Feng, additional, Ji, Fuling, additional, Pang, Zengchang, additional, Ordoñana, Juan R., additional, Sánchez-Romera, Juan F., additional, Colodro-Conde, Lucia, additional, Burt, S. Alexandra, additional, Klump, Kelly L., additional, Medland, Sarah E., additional, Montgomery, Grant W., additional, Kandler, Christian, additional, McAdams, Tom A., additional, Eley, Thalia C., additional, Gregory, Alice M., additional, Saudino, Kimberly J., additional, Dubois, Lise, additional, Boivin, Michel, additional, Haworth, Claire M. A., additional, Plomin, Robert, additional, Öncel, Sevgi Y., additional, Aliev, Fazil, additional, Stazi, Maria A., additional, Fagnani, Corrado, additional, D’Ippolito, Cristina, additional, Craig, Jeffrey M., additional, Saffery, Richard, additional, Siribaddana, Sisira H., additional, Hotopf, Matthew, additional, Sumathipala, Athula, additional, Spector, Timothy, additional, Mangino, Massimo, additional, Lachance, Genevieve, additional, Gatz, Margaret, additional, Butler, David A., additional, Bayasgalan, Gombojav, additional, Narandalai, Danshiitsoodol, additional, Freitas, Duarte L., additional, Maia, José Antonio, additional, Harden, K. Paige, additional, Tucker-Drob, Elliot M., additional, Christensen, Kaare, additional, Skytthe, Axel, additional, Kyvik, Kirsten O., additional, Hong, Changhee, additional, Chong, Youngsook, additional, Derom, Catherine A., additional, Vlietinck, Robert F., additional, Loos, Ruth J. F., additional, Cozen, Wendy, additional, Hwang, Amie E., additional, Mack, Thomas M., additional, He, Mingguang, additional, Ding, Xiaohu, additional, Chang, Billy, additional, Silberg, Judy L., additional, Eaves, Lindon J., additional, Maes, Hermine H., additional, Cutler, Tessa L., additional, Hopper, John L., additional, Aujard, Kelly, additional, Magnusson, Patrik K. E., additional, Pedersen, Nancy L., additional, Aslan, Anna K. Dahl, additional, Song, Yun-Mi, additional, Yang, Sarah, additional, Lee, Kayoung, additional, Baker, Laura A., additional, Tuvblad, Catherine, additional, Bjerregaard-Andersen, Morten, additional, Beck-Nielsen, Henning, additional, Sodemann, Morten, additional, Heikkilä, Kauko, additional, Tan, Qihua, additional, Zhang, Dongfeng, additional, Swan, Gary E., additional, Krasnow, Ruth, additional, Jang, Kerry L., additional, Knafo-Noam, Ariel, additional, Mankuta, David, additional, Abramson, Lior, additional, Lichtenstein, Paul, additional, Krueger, Robert F., additional, McGue, Matt, additional, Pahlen, Shandell, additional, Tynelius, Per, additional, Duncan, Glen E., additional, Buchwald, Dedra, additional, Corley, Robin P., additional, Huibregtse, Brooke M., additional, Nelson, Tracy L., additional, Whitfield, Keith E., additional, Franz, Carol E., additional, Kremen, William S., additional, Lyons, Michael J., additional, Ooki, Syuichi, additional, Brandt, Ingunn, additional, Nilsen, Thomas Sevenius, additional, Inui, Fujio, additional, Watanabe, Mikio, additional, Bartels, Meike, additional, van Beijsterveldt, Toos C. E. M., additional, Wardle, Jane, additional, Llewellyn, Clare H., additional, Fisher, Abigail, additional, Rebato, Esther, additional, Martin, Nicholas G., additional, Iwatani, Yoshinori, additional, Hayakawa, Kazuo, additional, Rasmussen, Finn, additional, Sung, Joohon, additional, Harris, Jennifer R., additional, Willemsen, Gonneke, additional, Busjahn, Andreas, additional, Goldberg, Jack H., additional, Boomsma, Dorret I., additional, Hur, Yoon-Mi, additional, Sørensen, Thorkild I. A., additional, and Kaprio, Jaakko, additional

Published
2015
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40. The Genetic Basis for Cognitive Ability, Memory, and Depression Symptomatology in Middle-Aged and Elderly Chinese Twins

Author

Xu, Chunsheng, primary, Sun, Jianping, additional, Ji, Fuling, additional, Tian, Xiaocao, additional, Duan, Haiping, additional, Zhai, Yaoming, additional, Wang, Shaojie, additional, Pang, Zengchang, additional, Zhang, Dongfeng, additional, Zhao, Zhongtang, additional, Li, Shuxia, additional, Hjelmborg, Jacob v.B., additional, Christensen, Kaare, additional, and Tan, Qihua, additional

Published
2015
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41. Genetic and Environmental Influences on Cardiovascular Disease Risk Factors: A Study of Chinese Twin Children and Adolescents

Author

Ji, Fuling, primary, Ning, Feng, additional, Duan, Haiping, additional, Kaprio, Jaakko, additional, Zhang, Dongfeng, additional, Zhang, Dong, additional, Wang, Shaojie, additional, Qiao, Qing, additional, Sun, Jianping, additional, Liang, Jiwei, additional, Pang, Zengchang, additional, and Silventoinen, Karri, additional

Published
2014
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42. Association between fruit, vegetable, seafood, and dairy intake and a reduction in the prevalence of type 2 diabetes in Qingdao, China.

Author

Jiwei Liang, Yanlei Zhang, Aili Xue, Jianping Sun, Xin Song, Bai Xue, Fuling Ji, Weiguo Gao, Liang He, Zengchang Pang, Qing Qiao, Feng Ning, Liang, Jiwei, Zhang, Yanlei, Xue, Aili, Sun, Jianping, Song, Xin, Xue, Bai, Ji, Fuling, and Gao, Weiguo

Subjects
*TYPE 2 diabetes prevention, *DISEASE prevalence, *SEAFOOD, *MEDICAL statistics, *DAIRY products, *DIET, *FRUIT, *TYPE 2 diabetes, *QUESTIONNAIRES, *SEX distribution, *SURVEYS, *VEGETABLES, *YOGURT, *LOGISTIC regression analysis, *CROSS-sectional method, *ODDS ratio
Abstract

Background and Objectives: Fruit, vegetable, seafood, and dairy intake may reduce the risk of type 2 diabetes, but this relationship is unclear. We aimed to examine the associations between fruit, vegetable, seafood, and dairy intake and type 2 diabetes prevalence in a Chinese population.Methods and Study Design: A total of 4,343 individuals aged 35-74 years participated in a population-based cross-sectional study in Qingdao, China. The frequency and quantity of fruit, vegetable, seafood, and dairy intake were determined using a standard food frequency questionnaire. Diabetes was classified according to the WHO/IDF 2006 criteria. Logistic regression analysis was employed to estimate odds ratio (OR) for type 2 diabetes in relation to fruit, vegetable, seafood, and dairy intake in a multivariable model.Results: The multivariate-adjusted ORs (95% confidence interval) for the presence of type 2 diabetes were 0.68 (0.46-0.98), 0.50 (0.37-0.68), and 0.91 (0.66-1.25), respectively, for the highest versus the lowest groups regarding total fruit and vegetable, fruit or vegetable intake in women. The ORs for type 2 diabetes prevalence regarding the quantity of fruit and vegetable, fruit, and yogurt intake were 0.88 (0.78-0.99), 0.71 (0.61-0.82), and 0.56 (0.32-0.98) in women, but not in men. Seafood consumption was inversely associated with diabetes risk in men, but not in women; the corresponding figures were 0.58 (0.35-0.96) and 0.92 (0.63-1.36), respectively.Conclusions: Fruit, vegetable, and yogurt intake in women and seafood intake in men were inversely associated with type 2 diabetes prevalence in this Chinese population. These findings require confirmation in a prospective study. [ABSTRACT FROM AUTHOR]

Published
2017
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