69,443 results on '"JIANZHONG AN"'
Search Results
2. Platelet ITGA2B inhibits caspase-8 and Rip3/Mlkl-dependent platelet death though PTPN6 during sepsis
- Author
-
Jiang Jiang, Wei Li, Lu Zhou, Dengping Liu, Yuanyuan Wang, Jianzhong An, Shigang Qiao, and Zhanli Xie
- Subjects
Natural sciences ,Biological sciences ,Physiology ,Pathophysiology ,Immunology ,Science - Abstract
Summary: Platelets play an important role in the pathogenesis of sepsis and platelet transfusion is a therapeutic option for sepsis patients, although the exact mechanisms have not been elucidated so far. ITGA2B encodes the αIIb protein in platelets, and its upregulation in sepsis is associated with increased mortality rate. Here, we generated a Itga2b (Q887X) knockin mouse, which significantly reduced ITGA2B expression of platelet and megakaryocyte. The decrease of ITGA2B level aggravated the death of septic mice. We analyzed the transcriptomic profiles of the platelets using RNA sequencing. Our findings suggest that ITGA2B upregulates PTPN6 in megakaryocytes via the transcription factors Nfkb1 and Rel. Furthermore, PTPN6 inhibits platelet apoptosis and necroptosis during sepsis by targeting the Ripk1/Ripk3/Mlkl and caspase-8 pathways. This prevents Kupffer cells from rapidly clearing activated platelets, and eventually maintains vascular integrity during sepsis. Our findings indicate a new function of ITGA2B in the regulation of platelet death during sepsis.
- Published
- 2023
- Full Text
- View/download PDF
3. Analysis of intercellular communication in the osteosarcoma microenvironment based on single cell sequencing data
- Author
-
Fangyi chen, Jiao Liu, Ting Yang, Jianwei Sun, Xianwei He, Xinjie Fu, Shigang Qiao, Jianzhong An, and Jiao Yang
- Subjects
Osteosarcoma ,Microenvironment ,Intercellular communication ,Single-cell sequencing ,Diseases of the musculoskeletal system ,RC925-935 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Osteosarcoma (OS) is the most common primary bone cancer in children and young adults, patient survival rates have not improved in recent decades. To further understand the interrelationship between different cell types in the tumor microenvironment of osteosarcoma, we comprehensively analyzed single-cell sequencing data from six patients with untreated osteosarcoma. Nine major cell types were identified from a total of 46,046 cells based on unbiased clustering of gene expression profiles and canonical markers. Osteosarcoma from different patients display heterogeneity in cellular composition. Myeloid cells were the most commonly represented cell type, followed by osteoblastic and TILs. Copy number variation (CNV) results identified amplifications and deletions in malignant osteoblastic cells and fibroblasts. Trajectory analysis based on RNA velocity showed that osteoclasts in the OS microenvironment could be differentiated from myeloid cells. Furthermore, we explored the intercellular communications in OS microenvironment and identified multiple ligand-receptor pairs between myeloid cells, osteoblastic cells and their cells, including 21 ligand-receptor pair genes that significantly associated with survival outcomes. Importantly, we found chemotherapy may have an effect on cellular communication in the OS microenvironment by analyzing single-cell sequencing data from seven primary osteosarcoma patients who received chemotherapy. We believe these observations will improve our understanding of potential mechanisms of microenvironment contributions to OS progression and help identify potential targets for new treatment development in the future.
- Published
- 2023
- Full Text
- View/download PDF
4. Single-cell RNA-seq of heart reveals intercellular communication drivers of myocardial fibrosis in diabetic cardiomyopathy
- Author
-
Wei Li, Xinqi Lou, Yingjie Zha, Yinyin Qin, Jun Zha, Lei Hong, Zhanli Xie, Shudi Yang, Chen Wang, Jianzhong An, Zhenhao Zhang, and Shigang Qiao
- Subjects
diabetic cardiomyopathy ,liver fibrosis ,retinal regeneration ,rat ,rabbit ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Myocardial fibrosis is the characteristic pathology of diabetes-induced cardiomyopathy. Therefore, an in-depth study of cardiac heterogeneity and cell-to-cell interactions can help elucidate the pathogenesis of diabetic myocardial fibrosis and identify treatment targets for the treatment of this disease. In this study, we investigated intercellular communication drivers of myocardial fibrosis in mouse heart with high-fat-diet/streptozotocin-induced diabetes at single-cell resolution. Intercellular and protein–protein interaction networks of fibroblasts and macrophages, endothelial cells, as well as fibroblasts and epicardial cells revealed critical changes in ligand–receptor interactions such as Pdgf(s)–Pdgfra and Efemp1–Egfr, which promote the development of a profibrotic microenvironment during the progression of and confirmed that the specific inhibition of the Pdgfra axis could significantly improve diabetic myocardial fibrosis. We also identified phenotypically distinct Hrchi and Postnhi fibroblast subpopulations associated with pathological extracellular matrix remodeling, of which the Hrchi fibroblasts were found to be the most profibrogenic under diabetic conditions. Finally, we validated the role of the Itgb1 hub gene-mediated intercellular communication drivers of diabetic myocardial fibrosis in Hrchi fibroblasts, and confirmed the results through AAV9-mediated Itgb1 knockdown in the heart of diabetic mice. In summary, cardiac cell mapping provides novel insights into intercellular communication drivers involved in pathological extracellular matrix remodeling during diabetic myocardial fibrosis.
- Published
- 2023
- Full Text
- View/download PDF
5. RIPK1-RIPK3 mediates myocardial fibrosis in type 2 diabetes mellitus by impairing autophagic flux of cardiac fibroblasts
- Author
-
Shigang Qiao, Lei Hong, Yongming Zhu, Jun Zha, An Wang, Jia Qiu, Wei Li, Chen Wang, Jianzhong An, and Huiling Zhang
- Subjects
Cytology ,QH573-671 - Abstract
Abstract Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are critical regulators of programmed necrosis or necroptosis. However, the role of the RIPK1/RIPK3 signaling pathway in myocardial fibrosis and related diabetic cardiomyopathy is still unclear. We hypothesized that RIPK1/RIPK3 activation mediated myocardial fibrosis by impairing the autophagic flux. To this end, we established in vitro and in vivo models of type 2 diabetes mellitus with high glucose fat (HGF) medium and diet respectively. HGF induced myocardial fibrosis, and impaired cardiac diastolic and systolic function by activating the RIPK1/RIPK3 pathway, which increased the expression of autophagic related proteins such as LC3-II, P62 and active-cathepsin D. Inhibition of RIPK1 or RIPK3 alleviated HGF-induced death and fibrosis of cardiac fibroblasts by restoring the impaired autophagic flux. The autophagy blocker neutralized the effects of the RIPK1 inhibitor necrostatin-1 (Nec-1) and RIPK3 inhibitor GSK872 (GSK). RIPK1/RIPK3 inhibition respectively decreased the levels of RIPK3/p-RIPK3 and RIPK1/p-RIPK1. P62 forms a complex with RIPK1-RIPK3 and promotes the binding of RIPK1 and RIPK3, silencing of RIPK1 decreased the association of RIPK1 with P62 and the binding of P62 to LC3. Furthermore, inhibition of both kinases in combination with a low dose of Nec-1 and GSK in the HGF-treated fibroblasts significantly decreased cell death and fibrosis, and restored the autophagic flux. In the diabetic rat model, Nec-1 (1.65 mg/kg) treatment for 4 months markedly alleviated myocardial fibrosis, downregulated autophagic related proteins, and improved cardiac systolic and diastolic function. In conclusion, HGF induces myocardial fibrosis and cardiac dysfunction by activating the RIPK1-RIPK3 pathway and by impairing the autophagic flux, which is obviated by the pharmacological and genetic inhibition of RIPK1/RIPK3.
- Published
- 2022
- Full Text
- View/download PDF
6. Learned Indexes with Distribution Smoothing via Virtual Points
- Author
-
Amarasinghe, Kasun, Choudhury, Farhana, Qi, Jianzhong, and Bailey, James
- Subjects
Computer Science - Databases - Abstract
Recent research on learned indexes has created a new perspective for indexes as models that map keys to their respective storage locations. These learned indexes are created to approximate the cumulative distribution function of the key set, where using only a single model may have limited accuracy. To overcome this limitation, a typical method is to use multiple models, arranged in a hierarchical manner, where the query performance depends on two aspects: (i) traversal time to find the correct model and (ii) search time to find the key in the selected model. Such a method may cause some key space regions that are difficult to model to be placed at deeper levels in the hierarchy. To address this issue, we propose an alternative method that modifies the key space as opposed to any structural or model modifications. This is achieved through making the key set more learnable (i.e., smoothing the distribution) by inserting virtual points. Further, we develop an algorithm named CSV to integrate our virtual point insertion method into existing learned indexes, reducing both their traversal and search time. We implement CSV on state-of-the-art learned indexes and evaluate them on real-world datasets. The extensive experimental results show significant query performance improvement for the keys in deeper levels of the index structures at a low storage cost.
- Published
- 2024
7. Demystifying and Detecting Cryptographic Defects in Ethereum Smart Contracts
- Author
-
Zhang, Jiashuo, Shen, Yiming, Chen, Jiachi, Su, Jianzhong, Wang, Yanlin, Chen, Ting, Gao, Jianbo, and Chen, Zhong
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Software Engineering - Abstract
Ethereum has officially provided a set of system-level cryptographic APIs to enhance smart contracts with cryptographic capabilities. These APIs have been utilized in over 10% of Ethereum transactions, motivating developers to implement various on-chain cryptographic tasks, such as digital signatures. However, since developers may not always be cryptographic experts, their ad-hoc and potentially defective implementations could compromise the theoretical guarantees of cryptography, leading to real-world security issues. To mitigate this threat, we conducted the first study aimed at demystifying and detecting cryptographic defects in smart contracts. Through the analysis of 2,406 real-world security reports, we defined nine types of cryptographic defects in smart contracts with detailed descriptions and practical detection patterns. Based on this categorization, we proposed CrySol, a fuzzing-based tool to automate the detection of cryptographic defects in smart contracts. It combines transaction replaying and dynamic taint analysis to extract fine-grained crypto-related semantics and employs crypto-specific strategies to guide the test case generation process. Furthermore, we collected a large-scale dataset containing 25,745 real-world crypto-related smart contracts and evaluated CrySol's effectiveness on it. The result demonstrated that CrySol achieves an overall precision of 95.4% and a recall of 91.2%. Notably, CrySol revealed that 5,847 (22.7%) out of 25,745 smart contracts contain at least one cryptographic defect, highlighting the prevalence of these defects.
- Published
- 2024
8. Multi-Grained Contrast for Data-Efficient Unsupervised Representation Learning
- Author
-
Shen, Chengchao, Chen, Jianzhong, and Wang, Jianxin
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
The existing contrastive learning methods mainly focus on single-grained representation learning, e.g., part-level, object-level or scene-level ones, thus inevitably neglecting the transferability of representations on other granularity levels. In this paper, we aim to learn multi-grained representations, which can effectively describe the image on various granularity levels, thus improving generalization on extensive downstream tasks. To this end, we propose a novel Multi-Grained Contrast method (MGC) for unsupervised representation learning. Specifically, we construct delicate multi-grained correspondences between positive views and then conduct multi-grained contrast by the correspondences to learn more general unsupervised representations. Without pretrained on large-scale dataset, our method significantly outperforms the existing state-of-the-art methods on extensive downstream tasks, including object detection, instance segmentation, scene parsing, semantic segmentation and keypoint detection. Moreover, experimental results support the data-efficient property and excellent representation transferability of our method. The source code and trained weights are available at \url{https://github.com/visresearch/mgc}.
- Published
- 2024
9. Factual Dialogue Summarization via Learning from Large Language Models
- Author
-
Zhu, Rongxin, Lau, Jey Han, and Qi, Jianzhong
- Subjects
Computer Science - Computation and Language ,F.2.2 ,I.2.7 - Abstract
Factual consistency is an important quality in dialogue summarization. Large language model (LLM)-based automatic text summarization models generate more factually consistent summaries compared to those by smaller pretrained language models, but they face deployment challenges in real-world applications due to privacy or resource constraints. In this paper, we investigate the use of symbolic knowledge distillation to improve the factual consistency of smaller pretrained models for dialogue summarization. We employ zero-shot learning to extract symbolic knowledge from LLMs, generating both factually consistent (positive) and inconsistent (negative) summaries. We then apply two contrastive learning objectives on these summaries to enhance smaller summarization models. Experiments with BART, PEGASUS, and Flan-T5 indicate that our approach surpasses strong baselines that rely on complex data augmentation strategies. Our approach achieves better factual consistency while maintaining coherence, fluency, and relevance, as confirmed by various automatic evaluation metrics. We also provide access to the data and code to facilitate future research.
- Published
- 2024
10. SmartOracle: Generating Smart Contract Oracle via Fine-Grained Invariant Detection
- Author
-
Su, Jianzhong, Chen, Jiachi, Fang, Zhiyuan, Lin, Xingwei, Tang, Yutian, and Zheng, Zibin
- Subjects
Computer Science - Software Engineering ,Computer Science - Cryptography and Security - Abstract
As decentralized applications (DApps) proliferate, the increased complexity and usage of smart contracts have heightened their susceptibility to security incidents and financial losses. Although various vulnerability detection tools have been developed to mitigate these issues, they often suffer poor performance in detecting vulnerabilities, as they either rely on simplistic and general-purpose oracles that may be inadequate for vulnerability detection, or require user-specified oracles, which are labor-intensive to create. In this paper, we introduce SmartOracle, a dynamic invariant detector that automatically generates fine-grained invariants as application-specific oracles for vulnerability detection. From historical transactions, SmartOracle uses pattern-based detection and advanced inference to construct comprehensive properties, and mines multi-layer likely invariants to accommodate the complicated contract functionalities. After that, SmartOracle identifies smart contract vulnerabilities by hunting the violated invariants in new transactions. In the field of invariant detection, SmartOracle detects 50% more ERC20 invariants than existing dynamic invariant detection and achieves 96% precision rate. Furthermore, we build a dataset that contains vulnerable contracts from real-world security incidents. SmartOracle successfully detects 466 abnormal transactions with an acceptable precision rate 96%, involving 31 vulnerable contracts. The experimental results demonstrate its effectiveness in detecting smart contract vulnerabilities, especially those related to complicated contract functionalities.
- Published
- 2024
11. Convex-area-wise Linear Regression and Algorithms for Data Analysis
- Author
-
Lyu, Bohan and Li, Jianzhong
- Subjects
Computer Science - Databases - Abstract
This paper introduces a new type of regression methodology named as Convex-Area-Wise Linear Regression(CALR), which separates given datasets by disjoint convex areas and fits different linear regression models for different areas. This regression model is highly interpretable, and it is able to interpolate any given datasets, even when the underlying relationship between explanatory and response variables are non-linear and discontinuous. In order to solve CALR problem, 3 accurate algorithms are proposed under different assumptions. The analysis of correctness and time complexity of the algorithms are given, indicating that the problem can be solved in $o(n^2)$ time accurately when the input datasets have some special features. Besides, this paper introduces an equivalent mixed integer programming problem of CALR which can be approximately solved using existing optimization solvers.
- Published
- 2024
12. Sample-specific Masks for Visual Reprogramming-based Prompting
- Author
-
Cai, Chengyi, Ye, Zesheng, Feng, Lei, Qi, Jianzhong, and Liu, Feng
- Subjects
Computer Science - Machine Learning ,Computer Science - Computer Vision and Pattern Recognition - Abstract
Visual reprogramming (VR) is a prompting technique that aims to re-purpose a pre-trained model (e.g., a classifier on ImageNet) to target tasks (e.g., medical data prediction) by learning a small-scale pattern added into input images instead of tuning considerable parameters within the model. The location of the pattern within input samples is usually determined by a pre-defined mask shared across all samples. In this paper, we show that the shared mask potentially limits VR's generalization and increases its approximation error due to the lack of sample-level adaptation. Motivated by this finding, we design a new framework for VR called sample-specific multi-channel masks (SMM). Specifically, SMM employs a lightweight ConvNet and patch-wise interpolation to generate sample-specific three-channel masks instead of a shared and pre-defined mask. Since we generate different masks for individual samples, SMM is theoretically shown to reduce approximation error for the target tasks compared with existing state-of-the-art VR methods. We also empirically demonstrate its performance gain on both ResNet and ViT. The success of SMM further highlights the broader applicability of VR in leveraging the latent knowledge of pre-trained models for various target tasks. Our code is available at https://github.com/tmlr-group/SMM.
- Published
- 2024
13. Omicron adopts a different strategy from Delta and other variants to adapt to host
- Author
-
Xiaohong Du, Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Ruhong Yan, Shigang Qiao, Jianzhong An, Chen Wang, and F. Xiao-Feng Qin
- Subjects
Medicine ,Biology (General) ,QH301-705.5 - Published
- 2022
- Full Text
- View/download PDF
14. Student Perceptions of Teacher Feedback Quality in Homework: Individual and Class-Level Factors
- Author
-
Jianzhong Xu
- Abstract
This study aimed to examine multilevel models posited to predict student perceptions of teacher feedback quality. A cross-sectional survey design was used, involving 1072 middle school students. We incorporated two clusters of variables: (a) student characteristics (gender, prior knowledge, parent education, homework expectancy, homework value, homework cost, and help seeking) and (b) the characteristics of the classroom context (perceived homework quality, autonomy support, and teacher monitoring). Perceived feedback quality was positively related to perceived autonomy support and homework quality at the individual and class levels. Meanwhile, perceived feedback quality was positively related to homework expectancy, homework value, and help seeking at the individual level.
- Published
- 2024
- Full Text
- View/download PDF
15. Revised Optimal design of power electronic transformer based on hybrid MMC under over-modulation operation
- Author
-
Zhang, Yaqian, Zhang, Xudong, Zhang, Jianzhong, and Deng, Fujin
- Subjects
Electrical Engineering and Systems Science - Systems and Control - Abstract
The bridge arm of the hybrid modular multilevel converter (MMC) is composed of half-bridge and full-bridge sub-modules cascaded together. Compared with the half-bridge MMC, it can operate in the boost-AC mode, where the modulation index can be higher than 1, and the DC voltage and the AC voltage level are no longer mutually constrained; compared with the full-bridge MMC, it has lower switching device costs and losses. When the hybrid MMC boost-AC mode is used in the power electronic transformer, the degree of freedom in system design is improved, and the cost and volume of the power electronic transformer system can be further reduced. This paper analyzes how to make full use of the newly added modulation index of freedom introduced by the boost-AC hybrid MMC to optimize the power electronic transformer system, and finally gives the optimal modulation index selection scheme of the hybrid MMC for different optimization objectives., Comment: 6 pages
- Published
- 2024
16. WiDRa -- Enabling Millimeter-Level Differential Ranging Accuracy in Wi-Fi Using Carrier Phase
- Author
-
Ratnam, Vishnu V., Sadiq, Bilal, Chen, Hao, Sun, Wei, Wu, Shunyao, Ng, Boon L., Jianzhong, and Zhang
- Subjects
Computer Science - Information Theory - Abstract
Although Wi-Fi is an ideal technology for many ranging applications, the performance of current methods is limited by the system bandwidth, leading to low accuracy of $\sim 1$ m. For many applications, measuring differential range, viz., the change in the range between adjacent measurements, is sufficient. Correspondingly, this work proposes WiDRa - a Wi-Fi based Differential Ranging solution that provides differential range estimates by using the sum-carrier-phase information. The proposed method is not limited by system bandwidth and can track range changes even smaller than the carrier wavelength. The proposed method is first theoretically justified, while taking into consideration the various hardware impairments affecting Wi-Fi chips. In the process, methods to isolate the sum-carrier phase from the hardware impairments are proposed. Extensive simulation results show that WiDRa can achieve a differential range estimation root-mean-square-error (RMSE) of $\approx 1$ mm in channels with a Rician-factor $\geq 7$ (a $100 \times$ improvement to existing methods). The proposed methods are also validated on off-the-shelf Wi-Fi hardware to demonstrate feasibility, where they achieve an RMSE of $< 1$ mm in the differential range. Finally, limitations of current investigation and future directions of exploration are suggested, to further tap into the potential of WiDRa., Comment: Accepted to IEEE JSAC special issue on Positioning and Sensing Over Wireless Networks, 2024
- Published
- 2024
17. Simultaneous Deep Learning of Myocardium Segmentation and T2 Quantification for Acute Myocardial Infarction MRI
- Author
-
Zhou, Yirong, Wang, Chengyan, Lu, Mengtian, Guo, Kunyuan, Wang, Zi, Ruan, Dan, Guo, Rui, Zhao, Peijun, Wang, Jianhua, Wu, Naiming, Lin, Jianzhong, Chen, Yinyin, Jin, Hang, Xie, Lianxin, Wu, Lilan, Zhu, Liuhong, Zhou, Jianjun, Cai, Congbo, Wang, He, and Qu, Xiaobo
- Subjects
Electrical Engineering and Systems Science - Image and Video Processing ,Computer Science - Artificial Intelligence - Abstract
In cardiac Magnetic Resonance Imaging (MRI) analysis, simultaneous myocardial segmentation and T2 quantification are crucial for assessing myocardial pathologies. Existing methods often address these tasks separately, limiting their synergistic potential. To address this, we propose SQNet, a dual-task network integrating Transformer and Convolutional Neural Network (CNN) components. SQNet features a T2-refine fusion decoder for quantitative analysis, leveraging global features from the Transformer, and a segmentation decoder with multiple local region supervision for enhanced accuracy. A tight coupling module aligns and fuses CNN and Transformer branch features, enabling SQNet to focus on myocardium regions. Evaluation on healthy controls (HC) and acute myocardial infarction patients (AMI) demonstrates superior segmentation dice scores (89.3/89.2) compared to state-of-the-art methods (87.7/87.9). T2 quantification yields strong linear correlations (Pearson coefficients: 0.84/0.93) with label values for HC/AMI, indicating accurate mapping. Radiologist evaluations confirm SQNet's superior image quality scores (4.60/4.58 for segmentation, 4.32/4.42 for T2 quantification) over state-of-the-art methods (4.50/4.44 for segmentation, 3.59/4.37 for T2 quantification). SQNet thus offers accurate simultaneous segmentation and quantification, enhancing cardiac disease diagnosis, such as AMI., Comment: 10 pages, 8 figures, 6 tables
- Published
- 2024
18. Integrated Monostatic Sensing and Full-Duplex Multiuser Communication for mmWave Systems
- Author
-
Bayraktar, Murat, González-Prelcic, Nuria, Valkama, Mikko, Chen, Hao, and Zhang, Charlie Jianzhong
- Subjects
Electrical Engineering and Systems Science - Signal Processing ,Computer Science - Information Theory - Abstract
In this paper, we propose a hybrid precoding/combining framework for communication-centric integrated sensing and full-duplex (FD) communication operating at mmWave bands. The designed precoders and combiners enable multiuser (MU) FD communication while simultaneously supporting monostatic sensing in a frequency-selective setting. The joint design of precoders and combiners involves the mitigation of self-interference (SI) caused by simultaneous transmission and reception at the FD base station (BS). Additionally, MU interference needs to be handled by the precoder/combiner design. The resulting optimization problem involves non-convex constraints since hybrid analog/digital architectures utilize networks of phase shifters. To solve the proposed problem, we separate the optimization of each precoder/combiner, and design each one of them while fixing the others. The precoders at the FD BS are designed by reformulating the communication and sensing constraints as signal-to-leakage-plus-noise ratio (SLNR) maximization problems that consider SI and MU interference as leakage. Furthermore, we design the frequency-flat analog combiner such that the residual SI at the FD BS is minimized under communication and sensing gain constraints. Finally, we design an interference-aware digital combining stage that separates MU signals and target reflections. The communication performance and sensing results show that the proposed framework efficiently supports both functionalities simultaneously., Comment: 13 pages, 7 figures
- Published
- 2024
19. DeepSeek-V2: A Strong, Economical, and Efficient Mixture-of-Experts Language Model
- Author
-
DeepSeek-AI, Liu, Aixin, Feng, Bei, Wang, Bin, Wang, Bingxuan, Liu, Bo, Zhao, Chenggang, Dengr, Chengqi, Ruan, Chong, Dai, Damai, Guo, Daya, Yang, Dejian, Chen, Deli, Ji, Dongjie, Li, Erhang, Lin, Fangyun, Luo, Fuli, Hao, Guangbo, Chen, Guanting, Li, Guowei, Zhang, H., Xu, Hanwei, Yang, Hao, Zhang, Haowei, Ding, Honghui, Xin, Huajian, Gao, Huazuo, Li, Hui, Qu, Hui, Cai, J. L., Liang, Jian, Guo, Jianzhong, Ni, Jiaqi, Li, Jiashi, Chen, Jin, Yuan, Jingyang, Qiu, Junjie, Song, Junxiao, Dong, Kai, Gao, Kaige, Guan, Kang, Wang, Lean, Zhang, Lecong, Xu, Lei, Xia, Leyi, Zhao, Liang, Zhang, Liyue, Li, Meng, Wang, Miaojun, Zhang, Mingchuan, Zhang, Minghua, Tang, Minghui, Li, Mingming, Tian, Ning, Huang, Panpan, Wang, Peiyi, Zhang, Peng, Zhu, Qihao, Chen, Qinyu, Du, Qiushi, Chen, R. J., Jin, R. L., Ge, Ruiqi, Pan, Ruizhe, Xu, Runxin, Chen, Ruyi, Li, S. S., Lu, Shanghao, Zhou, Shangyan, Chen, Shanhuang, Wu, Shaoqing, Ye, Shengfeng, Ma, Shirong, Wang, Shiyu, Zhou, Shuang, Yu, Shuiping, Zhou, Shunfeng, Zheng, Size, Wang, T., Pei, Tian, Yuan, Tian, Sun, Tianyu, Xiao, W. L., Zeng, Wangding, An, Wei, Liu, Wen, Liang, Wenfeng, Gao, Wenjun, Zhang, Wentao, Li, X. Q., Jin, Xiangyue, Wang, Xianzu, Bi, Xiao, Liu, Xiaodong, Wang, Xiaohan, Shen, Xiaojin, Chen, Xiaokang, Chen, Xiaosha, Nie, Xiaotao, Sun, Xiaowen, Wang, Xiaoxiang, Liu, Xin, Xie, Xin, Yu, Xingkai, Song, Xinnan, Zhou, Xinyi, Yang, Xinyu, Lu, Xuan, Su, Xuecheng, Wu, Y., Li, Y. K., Wei, Y. X., Zhu, Y. X., Xu, Yanhong, Huang, Yanping, Li, Yao, Zhao, Yao, Sun, Yaofeng, Li, Yaohui, Wang, Yaohui, Zheng, Yi, Zhang, Yichao, Xiong, Yiliang, Zhao, Yilong, He, Ying, Tang, Ying, Piao, Yishi, Dong, Yixin, Tan, Yixuan, Liu, Yiyuan, Wang, Yongji, Guo, Yongqiang, Zhu, Yuchen, Wang, Yuduan, Zou, Yuheng, Zha, Yukun, Ma, Yunxian, Yan, Yuting, You, Yuxiang, Liu, Yuxuan, Ren, Z. Z., Ren, Zehui, Sha, Zhangli, Fu, Zhe, Huang, Zhen, Zhang, Zhen, Xie, Zhenda, Hao, Zhewen, Shao, Zhihong, Wen, Zhiniu, Xu, Zhipeng, Zhang, Zhongyu, Li, Zhuoshu, Wang, Zihan, Gu, Zihui, Li, Zilin, and Xie, Ziwei
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence - Abstract
We present DeepSeek-V2, a strong Mixture-of-Experts (MoE) language model characterized by economical training and efficient inference. It comprises 236B total parameters, of which 21B are activated for each token, and supports a context length of 128K tokens. DeepSeek-V2 adopts innovative architectures including Multi-head Latent Attention (MLA) and DeepSeekMoE. MLA guarantees efficient inference through significantly compressing the Key-Value (KV) cache into a latent vector, while DeepSeekMoE enables training strong models at an economical cost through sparse computation. Compared with DeepSeek 67B, DeepSeek-V2 achieves significantly stronger performance, and meanwhile saves 42.5% of training costs, reduces the KV cache by 93.3%, and boosts the maximum generation throughput to 5.76 times. We pretrain DeepSeek-V2 on a high-quality and multi-source corpus consisting of 8.1T tokens, and further perform Supervised Fine-Tuning (SFT) and Reinforcement Learning (RL) to fully unlock its potential. Evaluation results show that, even with only 21B activated parameters, DeepSeek-V2 and its chat versions still achieve top-tier performance among open-source models.
- Published
- 2024
20. Learned Pulse Shaping Design for PAPR Reduction in DFT-s-OFDM
- Author
-
Carpi, Fabrizio, Rostami, Soheil, Cho, Joonyoung, Garg, Siddharth, Erkip, Elza, and Zhang, Charlie Jianzhong
- Subjects
Computer Science - Information Theory ,Computer Science - Machine Learning ,Electrical Engineering and Systems Science - Signal Processing - Abstract
High peak-to-average power ratio (PAPR) is one of the main factors limiting cell coverage for cellular systems, especially in the uplink direction. Discrete Fourier transform spread orthogonal frequency-domain multiplexing (DFT-s-OFDM) with spectrally-extended frequency-domain spectrum shaping (FDSS) is one of the efficient techniques deployed to lower the PAPR of the uplink waveforms. In this work, we propose a machine learning-based framework to determine the FDSS filter, optimizing a tradeoff between the symbol error rate (SER), the PAPR, and the spectral flatness requirements. Our end-to-end optimization framework considers multiple important design constraints, including the Nyquist zero-ISI (inter-symbol interference) condition. The numerical results show that learned FDSS filters lower the PAPR compared to conventional baselines, with minimal SER degradation. Tuning the parameters of the optimization also helps us understand the fundamental limitations and characteristics of the FDSS filters for PAPR reduction., Comment: 5 pages, under review
- Published
- 2024
21. Balanced Partitioning for Optimizing Big Graph Computation: Complexities and Approximation Algorithms
- Author
-
Ning, Baoling and Li, Jianzhong
- Subjects
Computer Science - Databases ,Computer Science - Data Structures and Algorithms - Abstract
Graph partitioning is a key fundamental problem in the area of big graph computation. Previous works do not consider the practical requirements when optimizing the big data analysis in real applications. In this paper, motivated by optimizing the big data computing applications, two typical problems of graph partitioning are studied. The first problem is to optimize the performance of specific workloads by graph partitioning, which lacks of algorithms with performance guarantees. The second problem is to optimize the computation of motifs by graph partitioning, which has not been focused by previous works. First, the formal definitions of the above two problems are introduced, and the semidefinite programming representations are also designed based on the analysis of the properties of the two problems. For the motif based partitioning problem, it is proved to be NP-complete even for the special case of $k=2$ and the motif is a triangle, and its inapproximability is also shown by proving that there are no efficient algorithms with finite approximation ratio. Finally, using the semidefinite programming and sophisticated rounding techniques, the bi-criteria $O(\sqrt{\log n\log k})$-approximation algorithms with polynomial time cost are designed and analyzed for them.
- Published
- 2024
22. Well-posedness and no-uniform dependence for the Euler-Poincar\'{e} equations in Triebel-Lizorkin spaces
- Author
-
Zhong, Yuanhua, Lu, Jianzhong, Li, Min, and Li, Jinlu
- Subjects
Mathematics - Analysis of PDEs ,35Q35 - Abstract
In this paper, we study the Cauchy problem of the Euler-Poincar\'{e} equations in $\R^d$ with initial data belonging to the Triebel-Lizorkin spaces. We prove the local-in-time unique existence of solutions to the Euler-Poincar\'{e} equations in $F^s_{p,r}(\R^d)$. Furthermore, we obtain that the data-to-solution of this equation is continuous but not uniformly continuous in these spaces., Comment: 17pages
- Published
- 2024
23. Corrigendum: Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity
- Author
-
Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, and F. Xiao-Feng Qin
- Subjects
SARS-CoV-2 ,N501Y.V1 ,N501Y.V2 ,infectivity ,thermal stability ,Microbiology ,QR1-502 - Published
- 2021
- Full Text
- View/download PDF
24. Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells
- Author
-
Lei Hong, Yingjie Zha, Chen Wang, Shigang Qiao, and Jianzhong An
- Subjects
type 2 diabetes ,diabetic cardiomyopathy ,folic acid ,pyroptosis ,hippo signal pathway ,Biology (General) ,QH301-705.5 - Abstract
Diabetic cardiomyopathy (DCM) is the leading cause of death in diabetic patients. Folic acid has a protective effect on diabetes-induced cardiomyocyte damage. The aim of this study was to explore the effects of folic acid on cardiomyocytes cultured under high glucose and fat (HGF) conditions and type 2 diabetes mellitus (T2DM) mice, and elucidate the underlying mechanisms. Bioinformatics analysis was used to identify the potential drugs through the Drug-Gene Interaction database. H9C2 cardiomyocytes were cultured with 30 mM glucose and 500 nM palmitic acid in the presence or absence of folic acid or YAP1 inhibitor (verteporfin) or YAP1 siRNA. The cell viability and lactate dehydrogenase (LDH) release were measured using specific assay kits. Pyroptosis was detected by flow cytometry. The concentrations of IL-1β and IL-18 in the supernatants were measured by ELISA. The NLRP3, ASC and caspase-1 mRNA levels were detected by qRT-PCR and that the proteins expression of NLRP3, ASC, cleaved caspase-1 (p10), caspase-1, YAP1, p-YAP1, LATS1 and P-LATS1 were detected by Western blotting. C57BL/6 mice were fed with high fat diet (HFD) combined with streptozotocin (STZ) intraperitoneally to establish a T2DM model, folic acid or PBS treatment for 8 weeks by oral gavage, blood glucose and body weight were measured every 4 weeks, mouse heart tissue was used to detect pyroptosis and hippo signaling pathway related protein expression. We identified 427 differentially expressed genes in the cardiac tissues of high fat diet + streptozotocin mice, among the 30 most significantly DEGs, folic acid was predicted to be the most likely therapeutic drug. Folic acid alleviated HGF-induced cell damage in vitro and in vivo by decreasing activation of the Hippo pathway, as indicated by lower LDH release and increased cell viability, and decreased expression of NLRP3, ASC, cleaved caspase-1, IL-1β, IL-18, p-YAP and p-LATS. Verteporfin or YAP1 siRNA neutralized the protective effect of folic acid by reversing YAP1-induced pyroptosis. Folic acid reduced NLRP3 inflammasome-mediated pyroptosis by down-regulating the Hippo signaling pathway, thereby effectively reducing T2DM-induced damage in H9C2 cells and animals.
- Published
- 2021
- Full Text
- View/download PDF
25. Characterization of SARS-CoV-2 Variants N501Y.V1 and N501Y.V2 Spike on Viral Infectivity
- Author
-
Haijun Tang, Long Gao, Zhao Wu, Fang Meng, Xin Zhao, Yun Shao, Xiaohua Shi, Shigang Qiao, Jianzhong An, Xiaohong Du, and F. Xiao-Feng Qin
- Subjects
SARS-CoV-2 ,N501Y.V1 ,N501Y.V2 ,infectivity ,thermal stability ,Microbiology ,QR1-502 - Abstract
SARS-coronavirus 2 (SARS-CoV-2), pathogen of coronavirus disease 2019 (COVID-19), is constantly evolving to adapt to the host and evade antiviral immunity. The newly emerging variants N501Y.V1 (B.1.1.7) and N501Y.V2 (B.1.351), first reported in the United Kingdom and South Africa respectively, raised concerns due to the unusually rapid global spread. The mutations in spike (S) protein may contribute to the rapid spread of these variants. Here, with a vesicular stomatitis virus (VSV)-based pseudotype system, we demonstrated that the pseudovirus bearing N501Y.V2 S protein has higher infection efficiency than pseudovirus with wildtype (WT) and D614G S protein. Moreover, pseudovirus with N501Y.V1 or N501Y.V2 S protein has better thermal stability than WT and D614G, suggesting these mutations of variants may increase the stability of SARS-CoV-2 S protein and virion. However, the pseudovirus bearing N501Y.V1 or N501Y.V2 S protein has similar sensitivity to inhibitors of protease and endocytosis with WT and D614G. These findings could be of value in preventing the spread of virus and developing drugs for emerging SARS-CoV-2 variants.
- Published
- 2021
- Full Text
- View/download PDF
26. Theoretical Analysis of Solvent Effect on NAPBr Dye's Two-photon Absorption Ability and Non-Radiative Transition in Lipid Droplets Detection
- Author
-
Wang, Hongyang, Wang, Xiaofei, Zhou, Yong, and Fan, Jianzhong
- Subjects
Physics - Chemical Physics ,Physics - Optics - Abstract
Two-photon fluorescence imaging has shown a promising application in biomedical imaging due to its outstanding advantages such as large penetration depth, low photo-damage, and photo-bleaching, etc. Among them, the two-photon fluorescent dye NAPBr, which can effectively select and monitor lipid droplets in living cells and biological tissues, has attracted extensive attention because of its excellent fluorescent properties. However, the research on the fluorescent abilities of two-photon fluorescent dyes in solvent environment is not sufficient. In our work, theoretical analysis reveals the internal mechanism of the solvent effect on geometric structure and photophysical properties of two-photon fluorescent dyes, especially non-radiative transition process, and holes-electrons distribution and transfer. This can provide a reference for the development of efficient two-photon absorption (TPA) molecules with aggregation-induced emission (AIE) characteristics. Related data also showed good regularity. Moreover, dye in four solvents have excellent photophysical properties: high fluorescence quantum efficiency (up to 66.60%), large Stokes shift (up to 108696 cm-1), and two-photon absorption cross section (up to 3658 GM). The medium dielectric constant solution environment can achieve a balance between two-photon absorption and fluorescence emission capabilities better, which lays a solid foundation for the study of TPA molecules with AIE functions in terms of solvent effects.
- Published
- 2024
27. Spatial-temporal Forecasting for Regions without Observations
- Author
-
Su, Xinyu, Qi, Jianzhong, Tanin, Egemen, Chang, Yanchuan, and Sarvi, Majid
- Subjects
Computer Science - Machine Learning - Abstract
Spatial-temporal forecasting plays an important role in many real-world applications, such as traffic forecasting, air pollutant forecasting, crowd-flow forecasting, and so on. State-of-the-art spatial-temporal forecasting models take data-driven approaches and rely heavily on data availability. Such models suffer from accuracy issues when data is incomplete, which is common in reality due to the heavy costs of deploying and maintaining sensors for data collection. A few recent studies attempted to address the issue of incomplete data. They typically assume some data availability in a region of interest either for a short period or at a few locations. In this paper, we further study spatial-temporal forecasting for a region of interest without any historical observations, to address scenarios such as unbalanced region development, progressive deployment of sensors or lack of open data. We propose a model named STSM for the task. The model takes a contrastive learning-based approach to learn spatial-temporal patterns from adjacent regions that have recorded data. Our key insight is to learn from the locations that resemble those in the region of interest, and we propose a selective masking strategy to enable the learning. As a result, our model outperforms adapted state-of-the-art models, reducing errors consistently over both traffic and air pollutant forecasting tasks. The source code is available at https://github.com/suzy0223/STSM., Comment: Accepted by EDBT2024
- Published
- 2024
28. DeepSeek LLM: Scaling Open-Source Language Models with Longtermism
- Author
-
DeepSeek-AI, Bi, Xiao, Chen, Deli, Chen, Guanting, Chen, Shanhuang, Dai, Damai, Deng, Chengqi, Ding, Honghui, Dong, Kai, Du, Qiushi, Fu, Zhe, Gao, Huazuo, Gao, Kaige, Gao, Wenjun, Ge, Ruiqi, Guan, Kang, Guo, Daya, Guo, Jianzhong, Hao, Guangbo, Hao, Zhewen, He, Ying, Hu, Wenjie, Huang, Panpan, Li, Erhang, Li, Guowei, Li, Jiashi, Li, Yao, Li, Y. K., Liang, Wenfeng, Lin, Fangyun, Liu, A. X., Liu, Bo, Liu, Wen, Liu, Xiaodong, Liu, Xin, Liu, Yiyuan, Lu, Haoyu, Lu, Shanghao, Luo, Fuli, Ma, Shirong, Nie, Xiaotao, Pei, Tian, Piao, Yishi, Qiu, Junjie, Qu, Hui, Ren, Tongzheng, Ren, Zehui, Ruan, Chong, Sha, Zhangli, Shao, Zhihong, Song, Junxiao, Su, Xuecheng, Sun, Jingxiang, Sun, Yaofeng, Tang, Minghui, Wang, Bingxuan, Wang, Peiyi, Wang, Shiyu, Wang, Yaohui, Wang, Yongji, Wu, Tong, Wu, Y., Xie, Xin, Xie, Zhenda, Xie, Ziwei, Xiong, Yiliang, Xu, Hanwei, Xu, R. X., Xu, Yanhong, Yang, Dejian, You, Yuxiang, Yu, Shuiping, Yu, Xingkai, Zhang, B., Zhang, Haowei, Zhang, Lecong, Zhang, Liyue, Zhang, Mingchuan, Zhang, Minghua, Zhang, Wentao, Zhang, Yichao, Zhao, Chenggang, Zhao, Yao, Zhou, Shangyan, Zhou, Shunfeng, Zhu, Qihao, and Zou, Yuheng
- Subjects
Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
The rapid development of open-source large language models (LLMs) has been truly remarkable. However, the scaling law described in previous literature presents varying conclusions, which casts a dark cloud over scaling LLMs. We delve into the study of scaling laws and present our distinctive findings that facilitate scaling of large scale models in two commonly used open-source configurations, 7B and 67B. Guided by the scaling laws, we introduce DeepSeek LLM, a project dedicated to advancing open-source language models with a long-term perspective. To support the pre-training phase, we have developed a dataset that currently consists of 2 trillion tokens and is continuously expanding. We further conduct supervised fine-tuning (SFT) and Direct Preference Optimization (DPO) on DeepSeek LLM Base models, resulting in the creation of DeepSeek Chat models. Our evaluation results demonstrate that DeepSeek LLM 67B surpasses LLaMA-2 70B on various benchmarks, particularly in the domains of code, mathematics, and reasoning. Furthermore, open-ended evaluations reveal that DeepSeek LLM 67B Chat exhibits superior performance compared to GPT-3.5.
- Published
- 2024
29. 3D Beamforming Through Joint Phase-Time Arrays
- Author
-
Yildiz, Ozlem, AlAmmouri, Ahmad, Mo, Jianhua, Nam, Younghan, Erkip, Elza, Jianzhong, and Zhang
- Subjects
Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
High-frequency wideband cellular communications over mmWave and sub-THz offer the opportunity for high data rates. However, it also presents high path loss, resulting in limited coverage. High-gain beamforming from the antenna array is essential to mitigate the coverage limitations. The conventional phased antenna arrays (PAA) cause high scheduling latency owing to analog beam constraints, i.e., only one frequency-flat beam is generated. Recently introduced joint phase-time array (JPTA) architecture, which utilizes both true-time-delay (TTD) units and phase shifters (PSs), alleviates analog beam constraints by creating multiple frequency-dependent beams for scheduling multiple users at different directions in a frequency-division manner. One class of previous studies offered solutions with ``rainbow" beams, which tend to allocate a small bandwidth per beam direction. Another class focused on uniform linear array (ULA) antenna architecture, whose frequency-dependent beams were designed along a single axis of either azimuth or elevation direction. This paper presents a novel 3D beamforming design that maximizes beamforming gain toward desired azimuth and elevation directions and across sub-bands partitioned according to scheduled users' bandwidth requirements. We provide analytical solutions and iterative algorithms to design the PSs and TTD units for a desired subband beam pattern. Through simulations of the beamforming gain, we observe that our proposed solutions outperform the state-of-the-art solutions reported elsewhere.
- Published
- 2024
30. Efficient Cost Modeling of Space-filling Curves
- Author
-
Liu, Guanli, Kulik, Lars, Jensen, Christian S., Li, Tianyi, and Qi, Jianzhong
- Subjects
Computer Science - Databases - Abstract
A space-filling curve (SFC) maps points in a multi-dimensional space to one-dimensional points by discretizing the multi-dimensional space into cells and imposing a linear order on the cells. This way, an SFC enables the indexing of multi-dimensional data using a one-dimensional index such as a B+-tree. Choosing an appropriate SFC is crucial, as different SFCs have different effects on query performance. Currently, there are two primary strategies: 1) deterministic schemes, which are computationally efficient but often yield suboptimal query performance, and 2) dynamic schemes, which consider a broad range of candidate SFCs based on cost functions but incur significant computational overhead. Despite these strategies, existing methods cannot efficiently measure the effectiveness of SFCs under heavy query workloads and numerous SFC options. To address this problem, we propose means of constant-time cost estimations that can enhance existing SFC selection algorithms, enabling them to learn more effective SFCs. Additionally, we propose an SFC learning method that leverages reinforcement learning and our cost estimation to choose an SFC pattern efficiently. Experimental studies offer evidence of the effectiveness and efficiency of the proposed means of cost estimation and SFC learning.
- Published
- 2023
31. Joint Phase-Time Arrays: A Paradigm for Frequency-Dependent Analog Beamforming in 6G
- Author
-
Ratnam, Vishnu V., Mo, Jianhua, AlAmmouri, Ahmad, Ng, Boon L., Jianzhong, Zhang, and Molisch, Andreas F.
- Subjects
Computer Science - Information Theory ,Electrical Engineering and Systems Science - Signal Processing - Abstract
Hybrid beamforming is an attractive solution to build cost-effective and energy-efficient transceivers for millimeter-wave and terahertz systems. However, conventional hybrid beamforming techniques rely on analog components that generate a frequency flat response such as phase-shifters and switches, which limits the flexibility of the achievable beam patterns. As a novel alternative, this paper proposes a new class of hybrid beamforming called Joint phase-time arrays (JPTA), that additionally use true-time delay elements in the analog beamforming to create frequency-dependent analog beams. Using as an example two important frequency-dependent beam behaviors, the numerous benefits of such flexibility are exemplified. Subsequently, the JPTA beamformer design problem to generate any desired beam behavior is formulated and near-optimal algorithms to the problem are proposed. Simulations show that the proposed algorithms can outperform heuristics solutions for JPTA beamformer update. Furthermore, it is shown that JPTA can achieve the two exemplified beam behaviors with one radio-frequency chain, while conventional hybrid beamforming requires the radio-frequency chains to scale with the number of antennas to achieve similar performance. Finally, a wide range of problems to further tap into the potential of JPTA are also listed as future directions., Comment: The paper is a revised version of the IEEE Access paper, that includes the full operation of Algorithms 1-3 to help curtail incorrect implementations
- Published
- 2023
- Full Text
- View/download PDF
32. Urban Region Representation Learning with Attentive Fusion
- Author
-
Sun, Fengze, Qi, Jianzhong, Chang, Yanchuan, Fan, Xiaoliang, Karunasekera, Shanika, and Tanin, Egemen
- Subjects
Computer Science - Machine Learning ,Computer Science - Databases - Abstract
An increasing number of related urban data sources have brought forth novel opportunities for learning urban region representations, i.e., embeddings. The embeddings describe latent features of urban regions and enable discovering similar regions for urban planning applications. Existing methods learn an embedding for a region using every different type of region feature data, and subsequently fuse all learned embeddings of a region to generate a unified region embedding. However, these studies often overlook the significance of the fusion process. The typical fusion methods rely on simple aggregation, such as summation and concatenation, thereby disregarding correlations within the fused region embeddings. To address this limitation, we propose a novel model named HAFusion. Our model is powered by a dual-feature attentive fusion module named DAFusion, which fuses embeddings from different region features to learn higher-order correlations between the regions as well as between the different types of region features. DAFusion is generic - it can be integrated into existing models to enhance their fusion process. Further, motivated by the effective fusion capability of an attentive module, we propose a hybrid attentive feature learning module named HALearning to enhance the embedding learning from each individual type of region features. Extensive experiments on three real-world datasets demonstrate that our model HAFusion outperforms state-of-the-art methods across three different prediction tasks. Using our learned region embedding leads to consistent and up to 31% improvements in the prediction accuracy.
- Published
- 2023
33. Understanding the Interaction Between the Divergence of Science and the Convergence of Technology Based on Polanyi’s Thoughts on Science
- Author
-
Li, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
34. An interactive dose optimizer based on population pharmacokinetic study to guide dosing of methotrexate in Chinese patients with osteosarcoma
- Author
-
Zhang, Yanjie, Qi, Xiemin, Huang, Xiaohui, Liu, Xiaozhou, Liu, Yanyu, Rui, Jianzhong, Yin, Qiong, Wu, Sujia, and Zhou, Guohua
- Published
- 2024
- Full Text
- View/download PDF
35. Exosomes derived from bone marrow mesenchymal stem cells induce the proliferation and osteogenic differentiation and regulate the inflammatory state in osteomyelitis in vitro model
- Author
-
Liang, Wei, Li, Yangui, Ji, Yihua, Kang, Renjie, Zhang, Kaixi, Su, Xueyuan, Li, Jiangbo, Ji, Mingming, Wu, Taiyong, Cao, Xinjie, Chen, Jianrui, and Huo, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
36. Synergistic Effects of Mg Alloying and Subsequent Homogenization Treatment to Improve the Microstructure and Properties of Al-Mg-Mn Alloys
- Author
-
Chen, Chengcheng, Wang, Xiangjie, Xu, Yajun, Song, Zhaoxi, Yu, Fang, Zhang, Zhaosong, Cui, Jianzhong, and Song, Dongfu
- Published
- 2024
- Full Text
- View/download PDF
37. Nonantibiotic prophylaxis for urinary tract infections: a network meta-analysis of randomized controlled trials
- Author
-
Han, Zeyu, Yi, Xianyanling, Li, Jin, Liao, Dazhou, and Ai, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
38. Frequency-dependent Electrical Capacitance and Resistance of Ultra-high Performance Concrete and Their Responses to Compressive Strain
- Author
-
Wu, Yu, Sun, Mingqing, Zhu, Lutao, Song, Qiulei, and Chen, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
39. Phase Equilibria of the CaO-SiO2-CeO2-Al2O3-MgO System at 1300°C and 1400°C
- Author
-
Shi, Junjie, Zhai, Yumo, Qiu, Yuchao, Jiang, Chenglong, Hou, Changle, Dong, Jingjing, and Li, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
40. Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration
- Author
-
Liu, Hui, Lu, Shuaiyan, Chen, Ming, Gao, Na, Yang, Yuhe, Hu, Huijuan, Ren, Qing, Liu, Xiaoyu, Chen, Hongxu, Zhu, Qunyan, Li, Shasha, and Su, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
41. Predictive model for the ignition and combustion behaviors of micron-sized aluminum particles in a water vapor environment
- Author
-
Zhang, Wenke, Liu, Jianzhong, Xu, Peihui, and Gao, Huanhuan
- Published
- 2024
- Full Text
- View/download PDF
42. Synergetic Effect of Sc Micro-alloying and Low-Frequency Electromagnetic Casting in 7A36 Aluminum Alloy with Enhanced Mechanical and Corrosion Properties
- Author
-
Yang, Lingfei, Yu, Fang, Chen, Chengcheng, Xu, Yajun, Song, Zhaoxi, Cui, Jianzhong, and Wang, Xiangjie
- Published
- 2024
- Full Text
- View/download PDF
43. Investigating factors influencing students’ regulation of homework emotion: integrating multiple theoretical perspectives
- Author
-
Xu, Jianzhong
- Published
- 2024
- Full Text
- View/download PDF
44. Production scheduling decision-making technology for multiple CNC machining centers with constraints on serviceable time
- Author
-
Qiu, Jianzhong, Wu, Jun, Chen, Xi, Zhao, Bingyan, and Fang, Yan
- Published
- 2024
- Full Text
- View/download PDF
45. Evolution of Broken Coal’s Permeability Characteristics under Cyclic Loading–Unloading Conditions
- Author
-
Luo, Liang, Zhang, Lei, Pan, Jianzhong, Li, Mingxue, Tian, Ye, Wang, Chen, and Li, Songzhao
- Published
- 2024
- Full Text
- View/download PDF
46. Death associated protein like 1 acts as a novel tumor suppressor in melanoma by increasing the stability of P21 protein
- Author
-
Liu, Xiaoyan, Hu, Xiaojuan, Jing, Meiyu, Huang, Lijin, You, Yaqi, Zhang, Yaru, Li, Ke, Tu, Yunhai, Liu, Youjia, Chen, Xiaogang, Su, Jianzhong, Hejtmancik, J. Fielding, Hou, Ling, and Ma, Xiaoyin
- Published
- 2024
- Full Text
- View/download PDF
47. Atorvastatin exerts a preventive effect against steroid-induced necrosis of the femoral head by modulating Wnt5a release
- Author
-
Wu, Junfeng, Chen, Tao, Zhang, Minghang, Li, Xing, Fu, Rongkun, Xu, Jianzhong, Nüssler, Andreas, and Gu, Chenxi
- Published
- 2024
- Full Text
- View/download PDF
48. Influenza virus uses mGluR2 as an endocytic receptor to enter cells
- Author
-
Ni, Zixin, Wang, Jinliang, Yu, Xiaofei, Wang, Yifan, Wang, Jingfei, He, Xijun, Li, Chengjun, Deng, Guohua, Shi, Jianzhong, Kong, Huihui, Jiang, Yongping, Chen, Pucheng, Zeng, Xianying, Tian, Guobin, Chen, Hualan, and Bu, Zhigao
- Published
- 2024
- Full Text
- View/download PDF
49. Targeted Poverty Alleviation for the Livelihood Improvement of Poverty-Stricken Households: A Case Study of Wuxi County, China
- Author
-
Zhang, Qianqian, Li, Tao, Yan, Jianzhong, Xie, Liuna, and Tan, Xiongwei
- Published
- 2024
- Full Text
- View/download PDF
50. AIE-based UiO-66/TiO2:fast response toluene detection and photocatalytic degradation
- Author
-
Yang, Fan, Ma, Jianzhong, Zhu, Qian, and Wang, John
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.