5 results on '"JIN‑YING SU"'
Search Results
2. Downregulation of microRNA-195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA
- Author
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Wen‑Jing Zhao, Jin‑Ying Su, and Hai‑Fang Zhang
- Subjects
0301 basic medicine ,VEGFA ,Male ,Vascular Endothelial Growth Factor A ,Cancer Research ,Angiogenesis ,Neovascularization, Physiologic ,Biology ,Biochemistry ,cerebral ischemia ,Neovascularization ,03 medical and health sciences ,angiogenesis ,Downregulation and upregulation ,miR-195 ,Cell Movement ,microRNA ,Genetics ,medicine ,Human Umbilical Vein Endothelial Cells ,Gene silencing ,Animals ,Cluster Analysis ,Humans ,Molecular Biology ,Tube formation ,Gene Expression Profiling ,Articles ,Cerebral Infarction ,Rats ,Endothelial stem cell ,Vascular endothelial growth factor A ,MicroRNAs ,030104 developmental biology ,Oncology ,Gene Expression Regulation ,Cancer research ,Molecular Medicine ,RNA Interference ,medicine.symptom - Abstract
Angiogenesis, the formation of new blood vessels from preexisting endothelium, is a process that involves a series of interassociated and mutually interactive pathophysiological processes. It is accepted that microRNAs (miRNAs) regulate endothelial cell behavior, including their involvement in angiogenesis. However, it remains unclear whether miRNAs are involved in the regulation of angiogenesis following cerebral ischemia. Therefore, the present study aimed to investigate the role of miRNAs in angiogenesis and the underlying mechanism following cerebral ischemia. Expression profiles of miRNAs in rat brain samples following middle cerebral artery occlusion (MCAO) were investigated using a miRNA microarray. The expression of candidate miRNA, miR‑195 was further validated using reverse transcription‑quantitative polymerase chain reaction. Then, the effects of miR‑195 on cell migration and tube formation of human umbilical vein vascular endothelial cells (HUVECs) were investigated following miR‑195 silencing, and overexpression. The specific target genes of miR‑195 were predicted using microRNA prediction bioinformatics software (http://www.microrna.org/microrna/home.do), and then confirmed using a dual‑luciferase reporter assay and rescue experiment. It was demonstrated that miR‑195 was significantly downregulated in the brains of rats following MCAO and in hypoxia‑induced HUVECs. Furthermore, it was revealed that miR‑195 overexpression inhibited the invasion ability and tube formation of HUVECs in vitro, while miR‑195 silencing enhanced these functions. In addition, vascular endothelial growth factor A (VEGFA) was identified as a direct target of miR‑195 and was negatively correlated with miR‑195 expression. In addition, the rescue experiment revealed that overexpression of VEGFA reversed the inhibitory effects of miR‑195 overexpression on the invasion ability and tube formation of HUVECs. The present study has provided a novel insight into the promoting roles of miR‑195 downregulation on angiogenesis following cerebral infarction and suggests that the miR‑195/VEGFA signaling pathway is a putative therapeutic target in cerebral ischemia.
- Published
- 2017
3. Modal Analysis on Transmission Gear Train of Planetary Reducer
- Author
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Jin Ying Su and Ju Zhou
- Subjects
Engineering ,Reducer ,business.industry ,Modal analysis ,General Engineering ,Natural frequency ,Structural engineering ,Vibration ,Noise ,Gear train ,Workbench ,Astrophysics::Earth and Planetary Astrophysics ,business ,Statics - Abstract
The planetary reducer has both internal incentive of varying mesh stiffness and external incentive of eccentric quality, which are prone to vibration and noise at work. This paper use ANSYS Workbench to build model, divide grid and carry out modal analysis for transmission gear train of Planetary reducer, and calculate the 6 order modes. The modal analysis result is compared with excited frequency and natural frequency respectively. This paper’s modal analysis is more accuracy, more rational and more scientific than the previous experience design and statics analysis. It not only provides the useful date for acoustic analysis of planetary reducer, but also provides theory basis for avoiding planetary reducer resonance, and lays a foundation for the whole system dynamic response calculation and analysis.
- Published
- 2012
4. Biomass-Based Rice (Oryza sativa L.) Aboveground Architectural Parameter Models
- Author
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Hong-xin CAO, Yan LIU, Yong-xia LIU, Jim Scott Hanan, Yan-bin YUE, Da-wei ZHU, Jian-fei LU, Jin-ying SUN, Chun-lin SHI, Dao-kuo GE, Xiu-fang WEI, An-qing YAO, Ping-ping TIAN, and Tai-lin BAO
- Subjects
biomass ,plant architectural parameter ,model ,rice (Oryza sativa L.) ,Agriculture (General) ,S1-972 - Abstract
To quantify the relationships between rice plant architecture parameters and the corresponding organ biomass, and to research on functional structural plant models of rice plant, this paper presented a biomass-based model of aboveground architectural parameters of rice (Oryza sativa L.) in the young seedling stage, designed to explain effects of cultivars and environmental conditions on rice aboveground morphogenesis at the individual leaf level. Various model variables, including biomass of blade and blade length, were parameterized for rice based on data derived from an outdoor experiment with rice cv. Liangyou 108, 86You 8, Nanjing 43, and Yangdao 6. The organ dimensions of rice aboveground were modelled taking corresponding organ biomass as an independent variable. Various variables in rice showed marked consistency in observation and simulation, suggesting possibilities for a general rice architectural model in the young seedling stage. Our descriptive model was suitable for our objective. However, they can set the stage for connection to physiological model via biomass and development of functional structural rice models (FSRM), and start with the localized production and partitioning of assimilates as affected by abiotic growth factors. The finding of biomass-based rice architectural parameter models also can be used in morphological models of blade, sheath, and tiller of the other stages in rice life.
- Published
- 2012
- Full Text
- View/download PDF
5. Comparison of Crop Model Validation Methods
- Author
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Hong-xin CAO, Jim Scott HANAN, Yan LIU, Yong-xia LIU, Yan-bin YUE, Da-wei ZHU, Jian-fei LU, Jin-ying SUN, Chun-lin SHI, Dao-kuo GE, Xiu-fang WEI, An-qing YAO, Ping-ping TIAN, and Tai-lin BAO
- Subjects
crop models ,validation methods ,comparison ,Agriculture (General) ,S1-972 - Abstract
Abstract: In this paper, the many indices used in validation of crop models, such as RMSE (root mean square errors), Sd (standard error of absolute difference), da (mean absolute difference), dap (ratio of da to the mean observation), r (correlation), and R2 (determination coefficient), are compared for the same rice architectural parameter model, and their advantages and disadvantages are analyzed. A new index for validation of crop models, dap between the observed and the simulated values, is proposed, with dap
- Published
- 2012
- Full Text
- View/download PDF
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