756 results on '"JOOS, GUY"'
Search Results
2. Trajectory of neutrophilic responses in a mouse model of pollutant-aggravated allergic asthma
- Author
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De Volder, Joyceline, Bontinck, Annelies, De Grove, Katrien, Dirven, Iris, Haelterman, Valerie, Joos, Guy, Brusselle, Guy, and Maes, Tania
- Published
- 2023
- Full Text
- View/download PDF
3. Development and validation of an electronic daily control score for asthma (e-DASTHMA): a real-world direct patient data study
- Author
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Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S, Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H, Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G Walter, Cruz, Alvaro A, Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C, Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Luna Pech, Jorge, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E, Ohta, Ken, Papadopoulos, Nikolaos G, Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S, Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M, Fonseca, João A, and Bousquet, Jean
- Published
- 2023
- Full Text
- View/download PDF
4. Anti–Interleukin-5 Therapy Is Associated with Attenuated Lung Function Decline in Severe Eosinophilic Asthma Patients From the Belgian Severe Asthma Registry
- Author
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Graff, Sophie, Brusselle, Guy, Hanon, Shane, Sohy, Carine, Dupont, Lieven, Peche, Rudy, Michils, Alain, Pilette, Charles, Joos, Guy, Lahousse, Lies, Lapperre, Therese, Louis, Renaud, and Schleich, Florence
- Published
- 2022
- Full Text
- View/download PDF
5. Early Integrated Palliative Home Care and Standard Care for End-Stage COPD (EPIC): A Phase II Pilot RCT Testing Feasibility, Acceptability, and Effectiveness
- Author
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Scheerens, Charlotte, Pype, Peter, Van Cauwenberg, Jelle, Vanbutsele, Gaëlle, Eecloo, Kim, Derom, Eric, Van Belle, Simon, Joos, Guy, Deliens, Luc, and Chambaere, Kenneth
- Published
- 2020
- Full Text
- View/download PDF
6. Neutrophilic responses in a subacute and chronic mouse model of pollutant-aggravated allergic asthma
- Author
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De Volder, Joyceline, primary, Bontinck, Annelies, additional, De Grove, Katrien, additional, Joos, Guy, additional, Brusselle, Guy, additional, and Maes, Tania, additional
- Published
- 2023
- Full Text
- View/download PDF
7. DPP4, the Middle East Respiratory Syndrome Coronavirus Receptor, is Upregulated in Lungs of Smokers and Chronic Obstructive Pulmonary Disease Patients
- Author
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Seys, Leen J. M., Widagdo, W., Verhamme, Fien M., Kleinjan, Alex, Janssens, Wim, Joos, Guy F., Bracke, Ken R., Haagmans, Bart L., and Brusselle, Guy G.
- Published
- 2018
8. Asthma and air pollution: recent insights in pathogenesis and clinical implications
- Author
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Bontinck, Annelies, Maes, Tania, and Joos, Guy
- Published
- 2019
- Full Text
- View/download PDF
9. Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA‐EAACI approach – ARIA‐EAACI Task Force Report
- Author
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Bousquet, Jean, primary, Shamji, Mohamed H., additional, Anto, Josep M., additional, Schünemann, Holger J., additional, Canonica, G. Walter, additional, Jutel, Marek, additional, Del Giacco, Stefano, additional, Zuberbier, Torsten, additional, Pfaar, Oliver, additional, Fonseca, Joao A., additional, Sousa‐Pinto, Bernardo, additional, Klimek, Ludger, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bosnic‐Anticevich, Sinthia, additional, Braido, Fulvio, additional, Chaves Loureiro, Claudia, additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Kulus, Marek, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Matricardi, Paolo M., additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Sofiev, Mikhail, additional, Toppila‐Salmi, Sanna, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Barbara, Cristina, additional, Bergmann, Karl C., additional, Bewick, Michael, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Boulet, Louis‐Philippe, additional, Bourret, Rodolphe, additional, Brusselle, Guy, additional, Brussino, Luisa, additional, Buhl, Roland, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Devillier, Philippe, additional, Dramburg, Stephanie, additional, Fokkens, Wytske J., additional, Gotua, Maia, additional, Heffler, Enrico, additional, Ispayeva, Zhanat, additional, Ivancevich, Juan Carlos, additional, Joos, Guy, additional, Kaidashev, Igor, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Lourenço, Olga, additional, Louis, Renaud, additional, Makela, Mika, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, O'Hehir, Robyn, additional, Okamoto, Yoshitaka, additional, Olze, Heidi, additional, Papadopoulos, Nikolaos G., additional, Papi, Alberto, additional, Patella, Vincenzo, additional, Pétré, Benoit, additional, Pham‐Thi, Nhân, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Roche, Nicolas, additional, Rouadi, Philip W., additional, Sá‐Sousa, Ana, additional, Sagara, Hironori, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sova, Milan, additional, Suppli Ulrik, Charlotte, additional, Taborda‐Barata, Luis, additional, Todo‐Bom, Ana, additional, Torres, Maria J., additional, Tsiligianni, Ioanna, additional, Usmani, Omar S., additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Vieira, Rafael José, additional, Wallace, Dana, additional, Waserman, Susan, additional, Zidarn, Mihaela, additional, Yorgancioglu, Arzu, additional, Zhang, Luo, additional, Chivato, Tomas, additional, and Ollert, Markus, additional
- Published
- 2023
- Full Text
- View/download PDF
10. Patient-centered digital biomarkers for allergic respiratory diseases and asthma:The ARIA-EAACI approach – ARIA-EAACI Task Force Report
- Author
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Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa-Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic-Anticevich, Sinthia, Braido, Fulvio, Chaves Loureiro, Claudia, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M, Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila-Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez-Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A, Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J, Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas-Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais-Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O'Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham-Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W, Sá-Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Suppli Ulrik, Charlotte, Taborda-Barata, Luis, Todo-Bom, Ana, Torres, Maria J, Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
- Abstract
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed., Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
- Published
- 2023
11. Correlation of BAL Cell Count and Pulmonary Function Tests in the Era of Antifibrotics: Data From the Belgium-Luxembourg Idiopathic Pulmonary Fibrosis Registry.
- Author
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Froidure, Antoine, Bondue, Benjamin, Dahlqvist, Caroline, Guiot, Julien, Gusbin, Natacha, Wirtz, Gil, Joos, Guy, Cataldo, Didier, Strens, Danielle, Slabbynck, Hans, Wuyts, Wim, Froidure, Antoine, Bondue, Benjamin, Dahlqvist, Caroline, Guiot, Julien, Gusbin, Natacha, Wirtz, Gil, Joos, Guy, Cataldo, Didier, Strens, Danielle, Slabbynck, Hans, and Wuyts, Wim
- Abstract
SCOPUS: ar.j, info:eu-repo/semantics/published
- Published
- 2023
12. Patient‐centred digital biomarkers for allergic respiratory diseases and asthma: the ARIA‐EAACI approach
- Author
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Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, Ollert, Markus, Bousquet, Jean, Shamji, Mohamed H., Anto, Josep M., Schünemann, Holger J., Canonica, G. Walter, Jutel, Marek, Del Giacco, Stefano, Zuberbier, Torsten, Pfaar, Oliver, Fonseca, Joao A., Sousa‐Pinto, Bernardo, Klimek, Ludger, Czarlewski, Wienczyslawa, Bedbrook, Anna, Amaral, Rita, Ansotegui, Ignacio J., Bosnic‐Anticevich, Sinthia, Braido, Fulvio, Loureiro, Claudia Chaves, Gemicioglu, Bilun, Haahtela, Tari, Kulus, Marek, Kuna, Piotr, Kupczyk, Maciej, Matricardi, Paolo M., Regateiro, Frederico S., Samolinski, Boleslaw, Sofiev, Mikhail, Toppila‐Salmi, Sanna, Valiulis, Arunas, Ventura, Maria Teresa, Barbara, Cristina, Bergmann, Karl C., Bewick, Michael, Blain, Hubert, Bonini, Matteo, Boulet, Louis‐Philippe, Bourret, Rodolphe, Brusselle, Guy, Brussino, Luisa, Buhl, Roland, Cardona, Victoria, Casale, Thomas, Cecchi, Lorenzo, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chu, Derek K., Cingi, Cemal, Costa, Elisio M., Cruz, Alvaro A., Devillier, Philippe, Dramburg, Stephanie, Fokkens, Wytske J., Gotua, Maia, Heffler, Enrico, Ispayeva, Zhanat, Ivancevich, Juan Carlos, Joos, Guy, Kaidashev, Igor, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Lourenço, Olga, Louis, Renaud, Makela, Mika, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, O’Hehir, Robyn, Okamoto, Yoshitaka, Olze, Heidi, Papadopoulos, Nikolaos G., Papi, Alberto, Patella, Vincenzo, Pétré, Benoit, Pham‐Thi, Nhân, Puggioni, Francesca, Quirce, Santiago, Roche, Nicolas, Rouadi, Philip W., Sá‐Sousa, Ana, Sagara, Hironori, Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sova, Milan, Ulrik, Charlotte Suppli, Taborda‐Barata, Luis, Todo‐Bom, Ana, Torres, Maria J., Tsiligianni, Ioanna, Usmani, Omar S., Valovirta, Erkka, Vasankari, Tuula, Vieira, Rafael José, Wallace, Dana, Waserman, Susan, Zidarn, Mihaela, Yorgancioglu, Arzu, Zhang, Luo, Chivato, Tomas, and Ollert, Markus
- Abstract
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the centre of the health system and is likely to optimise the practice of allergy. ARIA (Allergic Rhinitis and its Impact on Asthma) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomised controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, were embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
- Published
- 2023
- Full Text
- View/download PDF
13. Development and validation of an electronic daily control score for asthma (e-DASTHMA):a real-world direct patient data study
- Author
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Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., Bousquet, Jean, Sousa-Pinto, Bernardo, Jácome, Cristina, Pereira, Ana Margarida, Regateiro, Frederico S., Almeida, Rute, Czarlewski, Wienczyslawa, Kulus, Marek, Shamji, Mohamed H., Boulet, Louis-Philippe, Bonini, Matteo, Brussino, Luisa, Canonica, G. Walter, Cruz, Alvaro A., Gemicioglu, Bilun, Haahtela, Tari, Kupczyk, Maciej, Kvedariene, Violeta, Larenas-Linnemann, Desirée, Louis, Renaud, Niedoszytko, Marek, Pham-Thi, Nhân, Puggioni, Francesca, Romantowski, Jan, Sastre, Joaquin, Scichilone, Nicola, Taborda-Barata, Luis, Ventura, Maria Teresa, Vieira, Rafael José, Agache, Ioana, Bedbrook, Anna, Bergmann, Karl C., Amaral, Rita, Azevedo, Luís Filipe, Bosnic-Anticevich, Sinthia, Brusselle, Guy, Buhl, Roland, Cecchi, Lorenzo, Charpin, Denis, Loureiro, Claudia Chaves, de Blay, Frédéric, Del Giacco, Stefano, Devillier, Philippe, Jassem, Ewa, Joos, Guy, Jutel, Marek, Klimek, Ludger, Kuna, Piotr, Laune, Daniel, Pech, Jorge Luna, Makela, Mika, Morais-Almeida, Mario, Nadif, Rachel, Neffen, Hugo E., Ohta, Ken, Papadopoulos, Nikolaos G., Papi, Alberto, Pétré, Benoit, Pfaar, Oliver, Yeverino, Daniela Rivero, Cordeiro, Carlos Robalo, Roche, Nicolas, Sá-Sousa, Ana, Samolinski, Boleslaw, Sheikh, Aziz, Ulrik, Charlotte Suppli, Usmani, Omar S., Valiulis, Arunas, Vandenplas, Olivier, Vieira-Marques, Pedro, Yorgancioglu, Arzu, Zuberbier, Torsten, Anto, Josep M., Fonseca, João A., and Bousquet, Jean
- Abstract
Background: Validated questionnaires are used to assess asthma control over the past 1–4 weeks from reporting. However, they do not adequately capture asthma control in patients with fluctuating symptoms. Using the Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily asthma control score (e-DASTHMA). Methods: We used MASK-air data (freely available to users in 27 countries) to develop and assess different daily control scores for asthma. Data-driven control scores were developed based on asthma symptoms reported by a visual analogue scale (VAS) and self-reported asthma medication use. We included the daily monitoring data from all MASK-air users aged 16–90 years (or older than 13 years to 90 years in countries with a lower age of digital consent) who had used the app in at least 3 different calendar months and had reported at least 1 day of asthma medication use. For each score, we assessed construct validity, test–retest reliability, responsiveness, and accuracy. We used VASs on dyspnoea and work disturbance, EQ-5D-VAS, Control of Allergic Rhinitis and Asthma Test (CARAT), CARAT asthma, and Work Productivity and Activity Impairment: Allergy Specific (WPAI:AS) questionnaires as comparators. We performed an internal validation using MASK-air data from Jan 1 to Oct 12, 2022, and an external validation using a cohort of patients with physician-diagnosed asthma (the INSPIRERS cohort) who had had their diagnosis and control (Global Initiative for Asthma [GINA] classification) of asthma ascertained by a physician. Findings: We studied 135 635 days of MASK-air data from 1662 users from May 21, 2015, to Dec 31, 2021. The scores were strongly correlated with VAS dyspnoea (Spearman correlation coefficient range 0·68–0·82) and moderately correlated with work comparators and quality-of-life-related comparators (for WPAI:AS work, we observed Spearman correlation coefficients of 0·59–0·68). They also displayed high
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- 2023
14. Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses
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De Grove, Katrien C., Provoost, Sharen, Hendriks, Rudi W., McKenzie, Andrew N.J., Seys, Leen J.M., Kumar, Smitha, Maes, Tania, Brusselle, Guy G., and Joos, Guy F.
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- 2017
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15. Phenotype and Risk Burden of Sleep Apnea: A Population-Based Cohort Study
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Bauters, Fré A., Hertegonne, Katrien B., De Buyzere, Marc L., Joos, Guy F., Chirinos, Julio A., and Rietzschel, Ernst R.
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- 2019
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16. Correlation of BAL Cell Count and Pulmonary Function Tests in the Era of Antifibrotics
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Froidure, Antoine, primary, Bondue, Benjamin, additional, Dahlqvist, Caroline, additional, Guiot, Julien, additional, Gusbin, Natacha, additional, Wirtz, Gil, additional, Joos, Guy, additional, Cataldo, Didier, additional, Strens, Danielle, additional, Slabbynck, Hans, additional, and Wuyts, Wim A., additional
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- 2023
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17. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
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Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten
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- 2016
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18. Asthma inflammatory phenotypes show differential microRNA expression in sputum
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Maes, Tania, Cobos, Francisco Avila, Schleich, Florence, Sorbello, Valentina, Henket, Monique, De Preter, Katleen, Bracke, Ken R., Conickx, Griet, Mesnil, Claire, Vandesompele, Jo, Lahousse, Lies, Bureau, Fabrice, Mestdagh, Pieter, Joos, Guy F., Ricciardolo, Fabio L.M., Brusselle, Guy G., and Louis, Renaud
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- 2016
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19. Next-generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases
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Bousquet, J. Jean, Schünemann, Holger J., Togias, Alkis, Erhola, Marina, Hellings, Peter W., Zuberbier, Torsten, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bachert, Claus, Becker, Sven, Bedolla-Barajas, Martin, Bewick, Michael, Bosnic-Anticevich, Sinthia, Bosse, Isabelle, Boulet, Louis P., Bourrez, Jean Marc, Brusselle, Guy, Chavannes, Niels, Costa, Elisio, Cruz, Alvaro A., Czarlewski, Wienczyslawa, Fokkens, Wytske J., Fonseca, Joao A., Gaga, Mina, Haahtela, Tari, Illario, Maddalena, Klimek, Ludger, Kuna, Piotr, Kvedariene, Violeta, Le, L. T. T., Larenas-Linnemann, Desiree, Laune, Daniel, Lourenço, Olga M., Menditto, Enrica, Mullol, Joaquin, Okamoto, Yashitaka, Papadopoulos, Nikos, Pham-Thi, Nhân, Picard, Robert, Pinnock, Hilary, Roche, Nicolas, Roller-Wirnsberger, Regina E., Rolland, Christine, Samolinski, Boleslaw, Sheikh, Aziz, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Valiulis, Arunas, Valovirta, Erkka, Vasankari, Tuula, Ventura, Maria-Teresa, Walker, Samantha, Williams, Sian, Akdis, Cezmi A., Annesi-Maesano, Isabella, Arnavielhe, Sylvie, Basagana, Xavier, Bateman, Eric, Bedbrook, Anna, Bennoor, K. S., Benveniste, Samuel, Bergmann, Karl C., Bialek, Slawomir, Billo, Nils, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Bonini, Mateo, Bonniaud, Philippe, Bouchard, Jacques, Briedis, Vitalis, Brightling, Christofer E., Brozek, Jan, Buhl, Roland, Buonaiuto, Roland, Canonica, Giorgo W., Cardona, Victoria, Carriazo, Ana M., Carr, Warner, Cartier, Christine, Casale, Thomas, Cecchi, Lorenzo, Cepeda Sarabia, Alfonso M., Chkhartishvili, Eka, Chu, Derek K., Cingi, Cemal, Colgan, Elaine, de Sousa, Jaime Correia, Courbis, Anne Lise, Custovic, Adnan, Cvetkosvki, Biljana, D’Amato, Gennaro, da Silva, Jane, Dantas, Carina, Dokic, Dejand, Dauvilliers, Yves, Dedeu, Antoni, De Feo, Giulia, Devillier, Philippe, Di Capua, Stefania, Dykewickz, Marc, Dubakiene, Ruta, Ebisawa, Motohiro, El-Gamal, Yaya, Eller, Esben, Emuzyte, Regina, Farrell, John, Fink-Wagner, Antjie, Fiocchi, Alessandro, Fontaine, Jean F., Gemicioğlu, Bilun, Schmid-Grendelmeir, Peter, Gamkrelidze, Amiran, Garcia-Aymerich, Judith, Gomez, Maximiliano, González Diaz, Sandra, Gotua, Maia, Guldemond, Nick A., Guzmán, Maria-Antonieta, Hajjam, Jawad, O’B Hourihane, John, Humbert, Marc, Iaccarino, Guido, Ierodiakonou, Despo, Illario, Maddalena, Ivancevich, Juan C., Joos, Guy, Jung, Ki-Suck, Jutel, Marek, Kaidashev, Igor, Kalayci, Omer, Kardas, Przemyslaw, Keil, Thomas, Khaitov, Mussa, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Kowalski, Marek L., Kritikos, Vicky, Kull, Inger, Leonardini, Lisa, Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Louis, Renaud, Mair, Alpana, Marien, Gert, Mahboub, Bassam, Malva, Joao, Manning, Patrick, De Manuel Keenoy, Esteban, Marshall, Gailen D., Masjedi, Mohamed R., Maspero, Jorge F., Mathieu-Dupas, Eve, Matricardi, Poalo M., Melén, Eric, Melo-Gomes, Elisabete, Meltzer, Eli O., Menditto, Enrica, Mercier, Jacques, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Moda, Giuliana, Mogica-Martinez, Maria-Dolores, Mohammad, Yousser, Montefort, Steve, Monti, Ricardo, Morais-Almeida, Mario, Mösges, Ralf, Münter, Lars, Muraro, Antonella, Murray, Ruth, Naclerio, Robert, Napoli, Luigi, Namazova-Baranova, Leila, Neffen, Hugo, Nekam, Kristoff, Neou, Angelo, Novellino, Enrico, Nyembue, Dieudonné, O’Hehir, Robin, Ohta, Ken, Okubo, Kimi, Onorato, Gabrielle, Ouedraogo, Solange, Pali-Schöll, Isabella, Palkonen, Susanna, Panzner, Peter, Park, Hae-Sim, Pépin, Jean-Louis, Pereira, Ana-Maria, Pfaar, Oliver, Paulino, Ema, Phillips, Jim, Picard, Robert, Plavec, Davor, Popov, Ted A., Portejoie, Fabienne, Price, David, Prokopakis, Emmanuel P., Pugin, Benoit, Raciborski, Filip, Rajabian-Söderlund, Rojin, Reitsma, Sietze, Rodo, Xavier, Romano, Antonino, Rosario, Nelson, Rottem, Menahenm, Ryan, Dermot, Salimäki, Johanna, Sanchez-Borges, Mario M., Sisul, Juan-Carlos, Solé, Dirceu, Somekh, David, Sooronbaev, Talant, Sova, Milan, Spranger, Otto, Stellato, Cristina, Stelmach, Rafael, Suppli Ulrik, Charlotte, Thibaudon, Michel, To, Teresa, Todo-Bom, Ana, Tomazic, Peter V., Valero, Antonio A., Valenta, Rudolph, Valentin-Rostan, Marylin, van der Kleij, Rianne, Vandenplas, Olivier, Vezzani, Giorgio, Viart, Frédéric, Viegi, Giovanni, Wallace, Dana, Wagenmann, Martin, Wang, De Y., Waserman, Susan, Wickman, Magnus, Williams, Dennis M., Wong, Gary, Wroczynski, Piotr, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heahter J., Zeng, Stéphane, Zernotti, Mario, Zhang, Luo, Zhong, Nan S., Zidarn, Mihaela, the ARIA Study Group, and the MASK Study Group
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- 2019
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20. Monoclonal antibodies in type 2 asthma: a systematic review and network meta-analysis
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Edris, Ahmed, De Feyter, Silke, Maes, Tania, Joos, Guy, and Lahousse, Lies
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- 2019
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21. A randomised, double-blind, four-way, crossover trial comparing the 24-h FEV1 profile for once-daily versus twice-daily treatment with olodaterol, a novel long-acting β2-agonist, in patients with chronic obstructive pulmonary disease
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Joos, Guy F., Aumann, Joseph-Leon, Coeck, Carl, Korducki, Lawrence, Hamilton, Alan L., Kunz, Christina, and Aalbers, René
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- 2015
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22. RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
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Van Eeckhoutte, Hannelore P., primary, Donovan, Chantal, additional, Kim, Richard Y., additional, Conlon, Thomas M., additional, Ansari, Meshal, additional, Khan, Haroon, additional, Jayaraman, Ranjith, additional, Hansbro, Nicole G., additional, Dondelinger, Yves, additional, Delanghe, Tom, additional, Beal, Allison M., additional, Geddes, Brad, additional, Bertin, John, additional, Vanden Berghe, Tom, additional, De Volder, Joyceline, additional, Maes, Tania, additional, Vandenabeele, Peter, additional, Vanaudenaerde, Bart M., additional, Deforce, Dieter, additional, Škevin, Sonja, additional, Van Nieuwerburgh, Filip, additional, Verhamme, Fien M., additional, Joos, Guy F., additional, Idrees, Sobia, additional, Schiller, Herbert B., additional, Yildirim, Ali Önder, additional, Faiz, Alen, additional, Bertrand, Mathieu J.M., additional, Brusselle, Guy G., additional, Hansbro, Philip M., additional, and Bracke, Ken R., additional
- Published
- 2022
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23. Investigation of 5-HT4 receptors in bronchial hyperresponsiveness in cigarette smoke-exposed mice
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Dupont, Lisa L., Bracke, Ken R., De Maeyer, Joris H., Compan, Valérie, Joos, Guy F., Lefebvre, Romain A., and Brusselle, Guy G.
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- 2014
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24. “A palliative end-stage COPD patient does not exist”: a qualitative study of barriers to and facilitators for early integration of palliative home care for end-stage COPD
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Scheerens, Charlotte, Deliens, Luc, Van Belle, Simon, Joos, Guy, Pype, Peter, and Chambaere, Kenneth
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- 2018
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25. Correlation of Broncho-Alveolar Lavage Cell Count and Pulmonary Function Tests in the Era of Antifibrotics: Data from the Belgium-Luxembourg IPF registry
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Froidure, Antoine, Bondue, Benjamin, Dahlqvist, Caroline, Guiot, Julien, Gusbin, Natacha, Wirtz, Gil, Joos, Guy, Cataldo, Didier, Strens, Danielle, Slabbynck, Hans, Wuyts, Wim A, UCL - SSS/IREC/MONT - Pôle Mont Godinne, and UCL - (MGD) Service de pneumologie
- Subjects
pulmonary function test ,broncho-alveolar lavage ,clinical course ,Idiopathic pulmonary fibrosis - Abstract
Bronchoalveolar cell count at diagnosis is not linked to lung function decline and exacerbations in a large prospective cohort of idiopathic pulmonary fibrosis patients.
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- 2022
26. Anti-IL5 therapy is associated with attenuated lung function decline in severe eosinophilic asthma patients from the Belgian Severe Asthma Registry.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Graff, Sophie, Brusselle, Guy, Hanon, Shane, Sohy, Carine, Dupont, Lieven, Peche, Rudy, Michils, Alain, Pilette, Charles, Joos, Guy, Lahousse, Lies, Lapperre, Therese, Renaud, Louis, Schleich, Florence, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, Graff, Sophie, Brusselle, Guy, Hanon, Shane, Sohy, Carine, Dupont, Lieven, Peche, Rudy, Michils, Alain, Pilette, Charles, Joos, Guy, Lahousse, Lies, Lapperre, Therese, Renaud, Louis, and Schleich, Florence
- Abstract
BACKGROUND: Asthmatics have accelerated lung function decline over time compared with healthy individuals. OBJECTIVE: To evaluate risk factors for accelerated lung function decline. METHODS: In a longitudinal analysis on severe asthmatics enrolled in the Belgian Severe Asthma Registry with at least 2 visits a minimum of 12 months apart, we compared characteristics of patients with and without decline (loss of post-bronchodilation forced expiratory volume in 1 s [FEV1] (% predicted)/y greater than zero) over time. Multiple linear regression was applied to study the factors independently associated with FEV1 decline. RESULTS: In the overall population (n = 318), median annual FEV1 decline was 0.27 (-4.22 to 3.80) % predicted/y over a period of 23 months (12-41 months). Asthma was less controlled at baseline in nondecliners than in decliners (53%). Lung function and residual volume at baseline were higher in the declining group. Decliners presented with increased bronchial reactivity (ie, a lower provocative concentration of methacholine causing a 20% fall in FEV1) at baseline. Twenty-five percent of nondecliners were started on anti-interleukin-5 (anti-IL-5) for severe eosinophilic asthma during the study compared with 10% of decliners. The multivariable model suggested that Asthma Control Questionnaire score at baseline, late-onset asthma, and addition of anti-IL-5 during follow-up were associated with lower FEV1 decline, independently from other variables such as evolution in exacerbations, smoking status, inhaled corticosteroids or oral corticosteroids dose, or add-on anti-immunoglobulin E over time, whereas reversibility to salbutamol and higher FEV1 were associated with accelerated FEV1 decline. CONCLUSIONS: Add-on therapy with anti-IL-5 in severe eosinophilic asthma was associated with an attenuated FEV1 decline. The causality of this observation should, however, be confirmed in future prospective controlled studies.
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- 2022
27. Correlation of Broncho-Alveolar Lavage Cell Count and Pulmonary Function Tests in the Era of Antifibrotics: Data from the Belgium-Luxembourg IPF registry.
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UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie, Froidure, Antoine, Bondue, Benjamin, Dahlqvist, Caroline, Guiot, Julien, Gusbin, Natacha, Wirtz, Gil, Joos, Guy, Cataldo, Didier, Strens, Danielle, Slabbynck, Hans, Wuyts, Wim A, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de pneumologie, Froidure, Antoine, Bondue, Benjamin, Dahlqvist, Caroline, Guiot, Julien, Gusbin, Natacha, Wirtz, Gil, Joos, Guy, Cataldo, Didier, Strens, Danielle, Slabbynck, Hans, and Wuyts, Wim A
- Abstract
Bronchoalveolar cell count at diagnosis is not linked to lung function decline and exacerbations in a large prospective cohort of idiopathic pulmonary fibrosis patients.
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- 2022
28. ERS statement:A core outcome set for clinical trials evaluating the management of COPD exacerbations
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Mathioudakis, Alexander G., Abroug, Fekri, Agusti, Alvar, Ananth, Sachin, Bakke, Per, Bartziokas, Konstantinos, Beghe, Bianca, Bikov, Andras, Bradbury, Thomas, Brusselle, Guy, Cadus, Cordula, Coleman, Courtney, Contoli, Marco, Corlateanu, Alexandru, Corlateanu, Olga, Criner, Gerard J., Csoma, Balazs, Emelyanov, Alexander, Faner, Rosa, Romero, Gustavo Fernandez, Hammouda, Zeineb, Horváth, Peter, Garcia, Arturo Huerta, Jacobs, Michael, Jenkins, Christine, Joos, Guy, Kharevich, Olga, Kostikas, Konstantinos, Lapteva, Elena, Lazar, Zsofia, Leuppi, Joerg D., Liddle, Carol, Linnell, John, López-Giraldo, Alejandra, McDonald, Vanessa M., Nielsen, Rune, Papi, Alberto, Saraiva, Isabel, Sergeeva, Galina, Sioutkou, Agni, Sivapalan, Pradeesh, Stovold, Elizabeth, Wang, Hao, Wen, Fuqiang, Yorke, Janelle, Williamson, Paula R., Vestbo, Jørgen, Jensen, Jens Ulrik, Mathioudakis, Alexander G., Abroug, Fekri, Agusti, Alvar, Ananth, Sachin, Bakke, Per, Bartziokas, Konstantinos, Beghe, Bianca, Bikov, Andras, Bradbury, Thomas, Brusselle, Guy, Cadus, Cordula, Coleman, Courtney, Contoli, Marco, Corlateanu, Alexandru, Corlateanu, Olga, Criner, Gerard J., Csoma, Balazs, Emelyanov, Alexander, Faner, Rosa, Romero, Gustavo Fernandez, Hammouda, Zeineb, Horváth, Peter, Garcia, Arturo Huerta, Jacobs, Michael, Jenkins, Christine, Joos, Guy, Kharevich, Olga, Kostikas, Konstantinos, Lapteva, Elena, Lazar, Zsofia, Leuppi, Joerg D., Liddle, Carol, Linnell, John, López-Giraldo, Alejandra, McDonald, Vanessa M., Nielsen, Rune, Papi, Alberto, Saraiva, Isabel, Sergeeva, Galina, Sioutkou, Agni, Sivapalan, Pradeesh, Stovold, Elizabeth, Wang, Hao, Wen, Fuqiang, Yorke, Janelle, Williamson, Paula R., Vestbo, Jørgen, and Jensen, Jens Ulrik
- Abstract
Clinical trials evaluating the management of acute exacerbations of COPD assess heterogeneous outcomes, often omitting those that are clinically relevant or more important to patients. We have developed a core outcome set, a consensus-based minimum set of important outcomes that we recommend are evaluated in all future clinical trials on exacerbations management, to improve their quality and comparability. COPD exacerbations outcomes were identified through methodological systematic reviews and qualitative interviews with 86 patients from 11 countries globally. The most critical outcomes were prioritised for inclusion in the core outcome set through a two-round Delphi survey completed by 1063 participants (256 patients, 488 health professionals and 319 clinical academics) from 88 countries in five continents. Two global, multi-stakeholder, virtual consensus meetings were conducted to 1) finalise the core outcome set and 2) prioritise a single measurement instrument to be used for evaluating each of the prioritised outcomes. Consensus was informed by rigorous methodological systematic reviews. The views of patients with COPD were accounted for at all stages of the project. Survival, treatment success, breathlessness, quality of life, activities of daily living, the need for a higher level of care, arterial blood gases, disease progression, future exacerbations and hospital admissions, treatment safety and adherence were all included in the core outcome set. Focused methodological research was recommended to further validate and optimise some of the selected measurement instruments. The panel did not consider the prioritised set of outcomes and associated measurement instruments to be burdensome for patients and health professionals to use.
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- 2022
29. Leptin as regulator of pulmonary immune responses: Involvement in respiratory diseases
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Vernooy, Juanita H.J., Ubags, Niki D.J., Brusselle, Guy G., Tavernier, Jan, Suratt, Benjamin T., Joos, Guy F., Wouters, Emiel F.M., and Bracke, Ken R.
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- 2013
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30. Statins, systemic inflammation and risk of death in COPD: The Rotterdam study
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Lahousse, Lies, Loth, Daan W., Joos, Guy F., Hofman, Albert, Leufkens, Hubert G.M., Brusselle, Guy G., and Stricker, Bruno H.
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- 2013
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31. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
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Mikus, Maria Sparreman, Kolmert, Johan, Andersson, Lars I., Östling, Jörgen, Knowles, Richard G., Gómez, Cristina, Ericsson, Magnus, Thörngren, John Olof, Khoonsari, Payam Emami, Dahlén, Barbro, Kupczyk, Maciej, de Meulder, Bertrand, Auffray, Charles, Bakke, Per S., Beghe, Bianca, Bel, Elisabeth H., Caruso, Massimo, Chanez, Pascal, Chawes, Bo, Fowler, Stephen J., Gaga, Mina, Geiser, Thomas, Gjomarkaj, Mark, Horváth, Ildikó, Howarth, Peter H., Johnston, Sebastian L., Joos, Guy, Krug, Norbert, Montuschi, Paolo, Musial, Jacek, Niżankowska-Mogilnicka, Ewa, Olsson, Henric K., Papi, Alberto, Rabe, Klaus F., Sandström, Thomas, Shaw, Dominick E., Siafakas, Nikolaos M., Uhlén, Mathias, Riley, John H., Bates, Stewart, Middelveld, Roelinde J.M., Wheelock, Craig E., Chung, Kian Fan, Adcock, Ian M., Sterk, Peter J., Bisgaard, Hans, Bønnelykke, Klaus, Vestbo, Jørgen, Vissing, Nadja H., and Olsson, Marianne
- Abstract
Rationale Asthma phenotyping requires novel biomarker discovery. Objectives To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterised cohorts of severe (SA) and mild-to-moderate (MMA) asthmatics, COPD subjects and healthy controls (HCs). Methods An antibody-based array targeting 177 proteins predominantly involved in pathways relevant to inflammation, lipid metabolism, signal transduction and extracellular matrix was applied to plasma from 525 asthmatics and HCs in the U-BIOPRED cohort, and 142 subjects with asthma and COPD from the validation cohort BIOAIR. Effects of oral corticosteroids (OCS) were determined by a 2-week, placebo-controlled OCS trial in BIOAIR, and confirmed by relation to objective OCS measures in U-BIOPRED. Results In U-BIOPRED, 110 proteins were significantly different, mostly elevated, in SA compared to MMA and HCs. 10 proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, TNF receptor superfamily member 11a, transforming growth factor-β and glutathione S-transferase). OCS treatment decreased most proteins, yet differences between SA and MMA remained following correction for OCS use. Consensus clustering of U-BIOPRED protein data yielded six clusters associated with asthma control, quality of life, blood neutrophils, high-sensitivity C-reactive protein and body mass index, but not Type-2 inflammatory biomarkers. The mast cell specific enzyme carboxypeptidase A3 was one major contributor to cluster differentiation. Conclusions The plasma proteomic panel revealed previously unexplored yet potentially useful Type-2independent biomarkers and validated several proteins with established involvement in the pathophysiology of SA.
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- 2022
32. Alcohol hyper‐responsiveness in chronic rhinosinusitis with nasal polyps
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De Schryver, Els, Derycke, Lara, Campo, Paloma, Gabriels, Eline, Joos, Guy F., Van Zele, Thibaut, Bachert, Claus, Hellings, Peter W., and Gevaert, Philippe
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- 2017
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33. MicroRNA Profiling Reveals a Role for MicroRNA-218-5p in the Pathogenesis of Chronic Obstructive Pulmonary Disease
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Conickx, Griet, Mestdagh, Pieter, Cobos, Francisco Avila, Verhamme, Fien M., Maes, Tania, Vanaudenaerde, Bart M., Seys, Leen J. M., Lahousse, Lies, Kim, Richard Y., Hsu, Alan C., Wark, Peter A., Hansbro, Philip M., Joos, Guy F., Vandesompele, Jo, Bracke, Ken R., and Brusselle, Guy G.
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- 2017
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34. Mast Cell Stabilizing Drugs
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Joos, Guy F., Peleman, Renaat A., Pauwels, Romain A., Parnham, Michael J., editor, Sampson, Anthony P., editor, and Church, Martin K., editor
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- 1999
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35. Unravelling the role of miR-223 in the regulation of pollutant-aggravated allergic airway inflammation
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Roffel, Mirjam, primary, Bontinck, Annelies, additional, De Volder, Joyceline, additional, Brandsma, Corry-Anke, additional, Skevin, Sonja, additional, Van Nieuwerburgh, Filip, additional, Joos, Guy, additional, Brusselle, Guy, additional, Bracke, Ken, additional, Van Den Berge, Maarten, additional, Heijink, Irene, additional, and Maes, Tania, additional
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- 2022
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36. Inhibiting RIPK1 kinase activity is protective in experimental models of COPD
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Van Eeckhoutte, Hannelore P., primary, Donovan, Chantal, additional, Kim, Richard, additional, Khan, Haroon, additional, Jayaraman, Ranjith, additional, Dondelinger, Yves, additional, Delanghe, Tom, additional, Beal, Allison, additional, Geddes, Brad, additional, Bertin, John, additional, Vanden Berghe, Tom, additional, Vandenabeele, Peter, additional, Vanaudenaerde, Bart, additional, Deforce, Dieter, additional, Skevin, Sonja, additional, Van Nieuwerburgh, Filip, additional, Verhamme, Fien, additional, Joos, Guy, additional, Brusselle, Guy, additional, Bertrand, Mathieu, additional, Hansbro, Philip, additional, and Bracke, Ken, additional
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- 2022
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37. Characterization of neutrophilic responses in a pollutant-aggravated asthma mouse model
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De Volder, Joyceline, primary, Bontinck, Annelies, additional, De Grove, Katrien, additional, Dirven, Iris, additional, Brusselle, Guy, additional, Joos, Guy, additional, and Maes, Tania, additional
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- 2022
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38. Development and Validation of an Electronic Daily Control Score for Asthma (e-DASTHMA)
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Sousa-Pinto, Bernardo, primary, Jácome, Cristina, additional, Pereira, Ana Margarida, additional, Regateiro, Frederico S., additional, Almeida, Rute, additional, Czarlewski, Wienczyslawa, additional, Kulus, Marek, additional, Shamji, Mohamed, additional, Boulet, Louis Philippe, additional, Bonini, Matteo, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cruz, Álvaro, additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Kupczyk, Maciej, additional, Kvedariene, Violeta, additional, Larenas-Linnemann, Desirée, additional, Louis, Renaud, additional, Niedoszytko, Marek, additional, Pham-Thi, Nhân, additional, Puggioni, Francesca, additional, Romantowski, Jan, additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Taborda-Barata, Luis, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Agache, Ioana, additional, Bedbrook, Anna, additional, Bergmann, Karl C., additional, Amaral, Rita, additional, Azevedo, Luís Filipe, additional, Bosnic-Anticevich, Sinthia, additional, Brusselle, Guy, additional, Buhl, Roland, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Loureiro, Claudia Chaves, additional, de Blay, Frédéric, additional, Del Giacco, Stefano, additional, Devillier, Philippe, additional, Jassem, Ewa, additional, Joos, Guy, additional, Jutel, Marek, additional, Klimek, Ludger, additional, Kuna, Piotr, additional, Laune, Daniel, additional, Pech, Jorge Luna, additional, Makela, Mika, additional, Morais-Almeida, Mario, additional, Nadif, Rachel, additional, Neffen, Hugo E., additional, Ohta, Ken, additional, Papadopoulos, Nikolaos G., additional, Papi, Alberto, additional, Pétré, Benoit, additional, Pfaar, Oliver, additional, Yeverino, Daniela Rivero, additional, Robalo-Cordeiro, Carlos, additional, Roche, Nicolas, additional, Sá-Sousa, Ana, additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Ulrik, Charlotte Suppli, additional, Usmani, Omar, additional, Valiulis, Arunas, additional, Vandenplas, Olivier, additional, Vieira-Marques, Pedro, additional, Yorgancioglu, Arzu, additional, Zuberbier, Torsten, additional, Antó, Josep M., additional, Fonseca, Joao A., additional, and Bousquet, Jean, additional
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- 2022
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39. Prevalence of atopy, asthma and COPD in an urban and a rural area of an African country
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Musafiri, Sanctus, van Meerbeeck, Jan, Musango, Laurent, Brusselle, Guy, Joos, Guy, Seminega, Benoit, and Rutayisire, Claver
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- 2011
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40. Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation
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Vandebriel, Rob, Callant Cransveld, Conchita, Crommelin, Daan, Diamant, Zuzana, Glazenburg, Berend, Joos, Guy, Kuper, Frieke, Natsch, Andreas, Nijkamp, Frans, Noteborn, Hub, Pieters, Raymond, Roberts, David, Roggen, Erwin, Rorije, Emiel, Seed, Martin, Sewald, Katharina, van den Heuvel, Rosette, van Engelen, Jacqueline, Verstraelen, Sandra, and van Loveren, Henk
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- 2011
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41. New insights into the immunology of chronic obstructive pulmonary disease
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Brusselle, Guy G, Joos, Guy F, and Bracke, Ken R
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- 2011
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42. Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation
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Sparreman Mikus, Maria, primary, Kolmert, Johan, additional, Andersson, Lars I., additional, Östling, Jörgen, additional, Knowles, Richard G., additional, Gómez, Cristina, additional, Ericsson, Magnus, additional, Thörngren, John-Olof, additional, Emami Khoonsari, Payam, additional, Dahlén, Barbro, additional, Kupczyk, Maciej, additional, De Meulder, Bertrand, additional, Auffray, Charles, additional, Bakke, Per S., additional, Beghe, Bianca, additional, Bel, Elisabeth H., additional, Caruso, Massimo, additional, Chanez, Pascal, additional, Chawes, Bo, additional, Fowler, Stephen J., additional, Gaga, Mina, additional, Geiser, Thomas, additional, Gjomarkaj, Mark, additional, Horváth, Ildikó, additional, Howarth, Peter H., additional, Johnston, Sebastian L., additional, Joos, Guy, additional, Krug, Norbert, additional, Montuschi, Paolo, additional, Musial, Jacek, additional, Niżankowska-Mogilnicka, Ewa, additional, Olsson, Henric K., additional, Papi, Alberto, additional, Rabe, Klaus F., additional, Sandström, Thomas, additional, Shaw, Dominick E., additional, Siafakas, Nikolaos M., additional, Uhlén, Mathias, additional, Riley, John H., additional, Bates, Stewart, additional, Middelveld, Roelinde J.M., additional, Wheelock, Craig E., additional, Chung, Kian Fan, additional, Adcock, Ian M., additional, Sterk, Peter J., additional, Djukanovic, Ratko, additional, Nilsson, Peter, additional, Dahlén, Sven-Erik, additional, and James, Anna, additional
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- 2021
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43. MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation
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Roffel, Mirjam P., primary, Maes, Tania, additional, Brandsma, Corry-Anke, additional, van den Berge, Maarten, additional, Vanaudenaerde, Bart M., additional, Joos, Guy F., additional, Brusselle, Guy G., additional, Heijink, Irene H., additional, and Bracke, Ken R., additional
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- 2021
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44. ERS statement: a core outcome set for clinical trials evaluating the management of COPD exacerbations
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Mathioudakis, Alexander G., primary, Abroug, Fekri, additional, Agusti, Alvar, additional, Ananth, Sachin, additional, Bakke, Per, additional, Bartziokas, Konstantinos, additional, Beghe, Bianca, additional, Bikov, Andras, additional, Bradbury, Thomas, additional, Brusselle, Guy, additional, Cadus, Cordula, additional, Coleman, Courtney, additional, Contoli, Marco, additional, Corlateanu, Alexandru, additional, Corlateanu, Olga, additional, Criner, Gerard J., additional, Csoma, Balazs, additional, Emelyanov, Alexander, additional, Faner, Rosa, additional, Fernandez Romero, Gustavo, additional, Hammouda, Zeineb, additional, Horváth, Peter, additional, Huerta Garcia, Arturo, additional, Jacobs, Michael, additional, Jenkins, Christine, additional, Joos, Guy, additional, Kharevich, Olga, additional, Kostikas, Konstantinos, additional, Lapteva, Elena, additional, Lazar, Zsofia, additional, Leuppi, Joerg D., additional, Liddle, Carol, additional, Linnell, John, additional, López-Giraldo, Alejandra, additional, McDonald, Vanessa M., additional, Nielsen, Rune, additional, Papi, Alberto, additional, Saraiva, Isabel, additional, Sergeeva, Galina, additional, Sioutkou, Agni, additional, Sivapalan, Pradeesh, additional, Stovold, Elizabeth, additional, Wang, Hao, additional, Wen, Fuqiang, additional, Yorke, Janelle, additional, Williamson, Paula R., additional, Vestbo, Jørgen, additional, and Jensen, Jens-Ulrik, additional
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- 2021
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45. Risk of Frailty in Elderly With COPD: A Population-Based Study
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Lahousse, Lies, Ziere, Gijsbertus, Verlinden, Vincentius J. A., Zillikens, M. Carola, Uitterlinden, André G., Rivadeneira, Fernando, Tiemeier, Henning, Joos, Guy F., Hofman, Albert, Ikram, M. Arfan, Franco, Oscar H., Brusselle, Guy G., and Stricker, Bruno H.
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- 2016
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46. Chronic Obstructive Pulmonary Disease and the Risk of Stroke. The Rotterdam Study
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Portegies, Marileen L. P., Lahousse, Lies, Joos, Guy F., Hofman, Albert, Koudstaal, Peter J., Stricker, Bruno H., Brusselle, Guy G., and Ikram, Arfan M.
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- 2016
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47. Sympathomimetics and Xanthines in the Treatment of Asthma
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Joos, Guy F., Pauwels, Romain A., Olivieri, D., editor, Barnes, P. J., editor, Hurd, S. S., editor, and Folco, G. C., editor
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- 1992
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48. Effects of Pulmonary Rehabilitation in Patients With Restrictive Lung Diseases
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Salhi, Bihiyga, Troosters, Thierry, Behaegel, Mia, Joos, Guy, and Derom, Eric
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- 2010
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49. Digital Health Europe (DHE) Twinning on severe asthma-kick-off meeting report
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Bousquet, Jean, Bedbrook, Anna, Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Fonseca, Joao A., Ballester, Miguel A. Gonzalez, Illario, Maddalena, Koskinen, Seppo, Laatikainen, Tiina, Onorato, Gabrielle L., Palkonen, Susanna, Patella, Vincenzo, Nhan, Pham-Thi, Puggioni, Francesca, Ventura, Maria Teresa, Joos, Guy, Kuna, Piotr, Louis, Renaud, Makris, Michael, Zalud, Petra, Zuberbier, Torsten, Bachert, Claus, Brussino, Luisa, Carreiro-Martins, Pedro, Carrion y Ribas, Carme, Chalubinski, Maciej, Costa, Elisio M., de Vries, Govert, Gemicioglu, Bilun, Gennimata, Dimitra, Micheli, Yann, Niedoszytko, Marek, Regateiro, Frederico S., Romantowski, Jan, Taborda-Barata, Luis, Toppila-Salmi, Sanna, Tsiligianni, Ioanna, Viart, Frederic, Laune, Daniel, HUS Inflammation Center, Department of Pathology, Department of Dermatology, Allergology and Venereology, and Helsinki University Hospital Area
- Subjects
ALLERGIC RHINITIS ,CHRONIC RESPIRATORY-DISEASES ,POLICY DEVELOPMENT ,ARIA ,3121 General medicine, internal medicine and other clinical medicine ,education ,INNOVATION PARTNERSHIP ,MULTIMORBIDITY ,IMPLEMENTATION ,AIR-POLLUTION ,GENERATION CARE PATHWAYS ,PERSON-CENTERED CARE - Abstract
Non
- Published
- 2021
50. Anti-IL5 therapy could prevent lung function decline in severe eosinophilic asthma: data from the belgian severe asthma registry
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Graff, Sophie, primary, Brusselle, Guy, additional, Hanon, Shane, additional, Sohy, Carine, additional, Dupont, Lieven, additional, Peche, Rudi, additional, Michils, Alain, additional, Pilette, Charles, additional, Joos, Guy, additional, Louis, Renaud, additional, and Schleich, Florence, additional
- Published
- 2021
- Full Text
- View/download PDF
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