118 results on '"Ja Yoon Ku"'
Search Results
2. Patient with recurrent paratesticular malignant mesothelioma and multiple primary neoplasms
- Author
-
Kyung Hwan Kim, Yury Lee, Ja Yoon Ku, Hong Koo Ha, and Hyun Jun Park
- Subjects
malignant mesothelioma ,multiple primary neoplasm ,testicular tumors ,Medicine (General) ,R5-920 - Abstract
Paratesticular malignant mesothelioma (MM) is a rare tumor frequently associated with asbestos exposure. Therefore, we present an even rarer case of a 78-year-old male patient diagnosed with multiple primary neoplasms, including prostate cancer, lung cancer, paratesticular MM, and upper tract urothelial carcinoma. The patient initially presented with a painless testicular mass and had a notable medical history of prostate and lung cancers. Following physical examination and an ultrasound evaluation, he underwent radical right inguinal orchiectomy, which revealed paratesticular MM. The patient’s lung cancer recurrence and subsequent treatment coincided with periods of no MM recurrence. However, after the lung cancer treatment, the MM recurred multiple times within short intervals. This unique case indicates that systemic treatments for lung cancer, specifically cisplatin-based chemotherapy and atezolizumab immunotherapy, might also have an anti-tumor effect on paratesticular MM. Although MM combined with multiple primary neoplasms is challenging to treat and frequently recurs, treatments for other malignancies, as evidenced in this case, may have suppressive effects on the recurrence and metastasis of MM.
- Published
- 2024
- Full Text
- View/download PDF
3. Prognostic value of the endothelial activation and stress index in patients with upper tract urothelial cancer undergoing radical nephroureterectomy
- Author
-
Jin Seok Gu, Ji Won Ryu, Seong Hyeon Yu, Ho Seok Chung, Jun Eul Hwang, Woo Kyun Bae, Ja Yoon Ku, Chan Ho Lee, Hong Koo Ha, Seung Il Jung, Eu Chang Hwang, and Dong Deuk Kwon
- Subjects
blood platelets ,carcinoma ,transitional cell ,creatinine ,lactate dehydrogenase ,prognosis ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose: The relationship with endothelial activation and stress index (EASIX), which represents the degree of endothelial dysfunction, is unwell known in upper tract urothelial carcinoma (UTUC). The present study aims to assess the prognostic value of the EASIX for recurrence-free survival (RFS) and overall survival (OS) in patients with UTUC who underwent radical nephroureterectomy (RNU). Materials and Methods: We retrospectively reviewed the clinical data of 627 patients with UTUC who underwent RNU without neoadjuvant chemotherapy at three hospitals between 2002 and 2019. EASIX scores were calculated using the formula “serum lactate dehydrogenase (U/L)×creatinine (mg/dL)/platelet count (109/L)” and evaluated based on log2-transformed values. We divided the patients according to the EASIX score (>1.27 vs. ≤1.27). Results: Among 627 patients, 380 were finally analyzed. Using maximally selected log-rank statistics, the optimal EASIX cutoff value was 1.27 on the log2 scale. The baseline characteristics were similar between the two groups except for age. The high EASIX score group had worse RFS and OS than the low EASIX score group (log-rank p=0.001 and p=0.006, respectively). At 5 years, the mean RFS and OS difference between the low and high EASIX score groups was 11.1 and 7.35 months, respectively. High EASIX score remained a key prognosticator of RFS and OS after RNU in multivariable analysis. Conclusions: EASIX score may represent endothelial dysfunction in patients with UTUC and may serve as a readily available prognostic factor for oncologic outcomes.
- Published
- 2022
- Full Text
- View/download PDF
4. Comparative Analysis of Proteomes and Phosphoproteomes in Patients with Prostate Cancer Using Different Surgical Conditions
- Author
-
Hee-Sung Ahn, Jeonghun Yeom, Hwangkyo Jeong, Won Young Park, Ja Yoon Ku, Byeong Jin Kang, Kyung Hwan Kim, Chan Ho Lee, Sangheon Song, Sun Sik Bae, Kyunggon Kim, and Hong Koo Ha
- Subjects
mass spectrometry ,prostatic hyperplasia ,prostatic neoplasm ,proteme ,transurethral resection of prostate ,Medicine ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Purpose: To establish the standard of procedure in preparing benign and cancerous prostate tissues and evaluate the quality of proteomics and phosphoproteomics during transurethral resection of the prostate (TUR-P) with different surgical conditions. Materials and Methods: TUR-P tissue samples from three patients, two diagnosed with prostate cancer and one with benign prostatic hyperplasia, were each analyzed under three different conditions, based on differences in energy values, tissue locations, and surgical techniques. Global- and phosphorylated proteomic profiles of prostate tissues were analyzed by liquid chromatography-tandem mass spectrometry. Results: A total of 6,019 global proteins and 4,280 phosphorylated peptides were identified in the nine tissues. The quantitative distributions of proteins and phosphorylation in tissues from the same patient were not affected by changes in the surgical conditions, but indirect relative comparisons differed among patients. Phosphorylation levels, especially of proteins involved in the androgen receptor pathway, important in prostate cancer, were preserved in each patient. Conclusions: Proteomic profiles of prostate tissue collected by TUR-P were not significantly affected by energy levels, tissue location, or surgical technique. In addition, since protein denaturation of samples through TUR-P is rarely confirmed in this study, we think that it will be an important guide for tissue samples in castration resistant prostate cancer patients, where it is difficult to obtain tissue. This result is the first report about proteomic and phosphoproteomic results with TUR-P samples in prostate cancer and will be theoretical basis in protein analysis research with prostate cancer tissues.
- Published
- 2022
- Full Text
- View/download PDF
5. Clinical factors that influence the occurrence of symptomatic pseudoaneurysms and arteriovenous fistulas after partial nephrectomy: multi-institutional study of renal function outcomes after one year of selective arterial embolization
- Author
-
Chan Ho Lee, Hong Koo Ha, Ja Yoon Ku, Won Ik Seo, and Seock Hwan Choi
- Subjects
Aneurysm, False ,Nephrectomy ,Arteriovenous Fistula ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
ABSTRACT Purpose: Renal artery pseudoaneurysms (RAPs) and arteriovenous fistulas (AVFs) are rare but potentially life-threatening complications after partial nephrectomy (PN). Selective arterial embolization (SAE) is an effective method for controlling RAPs/AVFs. We assessed the clinical factors affecting the occurrence of RAPs/AVFs after PN and the effects of SAE on postsurgical renal function. Materials and Methods: Four hundred ninety-three patients who underwent PN were retrospectively reviewed. They were placed in either the SAE or the non-SAE group. The effects of clinical factors, including R.E.N.A.L. scores, on the occurrence of RAPs/AVFs were analyzed. The influence of SAE on the estimated glomerular filtration rate (eGFR) during the first postoperative year was evaluated. Results: Thirty-three (6.7%) patients experienced RAPs/AVFs within 8 days of the median interval between PN and SAE. The SAE group had significantly higher R.E.N.A.L. scores, higher N component scores, and higher L component scores (all, p
- Published
- 2020
- Full Text
- View/download PDF
6. Comparison of allergens and symptoms in patients with allergic rhinitis between 1990s and 2010s
- Author
-
Ji Heui Kim, Shin Ae Kim, Ja Yoon Ku, Won Ki Cho, and Chol Ho Shin
- Subjects
Allergens ,Allergic Rhinitis ,Epidemiology ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Abstract Background The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently undergone rapid changes, corresponding changes in the characteristics of AR patients have not been well documented. Therefore, we aimed to outline the changes in allergens and clinical manifestations of AR in Korean patients from the 1990s and 2010s. Methods We reviewed 1447 and 3388 AR patients who visited the same tertiary hospital in the 1990s and 2010s, respectively. All patients were diagnosed with AR based on the presence of characteristic symptoms, positive skin prick test results, and answered a symptom questionnaire at the time of visit. We compared differences in the allergens and results of the symptom questionnaire between the two sets of patients. Results When compared with the 1990s, the rate of sensitization to house dust mites, cockroaches, Aspergillus, Alternaria, and tree pollen significantly increased and that to cat fur significantly decreased in patients from the 2010s (all P
- Published
- 2020
- Full Text
- View/download PDF
7. Cribriform Pattern at the Surgical Margin is Highly Predictive of Biochemical Recurrence in Patients Undergoing Radical Prostatectomy
- Author
-
Kyung Hwan Kim, Ja Yoon Ku, Chan Ho Lee, Won Young Park, and Hong Koo Ha
- Subjects
prostatectomy ,prostate-specific antigen ,prostatic neoplasms ,recurrence ,surgical margin ,Medicine (General) ,R5-920 - Abstract
Objectives We investigated the relationship between cribriform patterns and biochemical recurrence in patients with positive surgical margins after radical prostatectomy. Methods This study was based on radical prostatectomy specimens obtained from 817 patients (165 with margin-positive status) collected at a single center between 2010 and 2016. We retrospectively analyzed and compared body mass index, preoperative prostate-specific antigen, Gleason score, operative methods, postoperative Gleason score, pathological T-stage, tumor percentage involvement, lymphatic and perineural invasion, prostate-specific antigen nadir, location and length of the positive margin, cribriform pattern status, and Gleason grade at the surgical margin in terms of their association with biochemical recurrence. Risk factors for biochemical recurrence were also investigated. Results 21% (31/146) of surgical margin-positive patients had a cribriform pattern. Nadir prostate-specific antigen, perineural invasion and biochemical recurrence rates were significantly higher in cribriform pattern present group than absent group (P = 0.031, 0.043 and 0.045, respectively). According to the Cox regression model, postoperative Gleason score, tumor percentage involvement, location and length of the positive margin, and the presence of a cribriform pattern at the surgical margin were significant predictive factors of biochemical recurrence (P = 0.022, < 0.001, 0.015, 0.001, and 0.022, respectively). Moreover, the biochemical recurrence risk was approximately 3-fold higher in patients with a cribriform pattern at the surgical margin than in those without (HR: 3.41, 95% CI 1.20-9.70, P = 0.022). Conclusions A cribriform pattern at the surgical margin is a significant predictor of biochemical recurrence in patients who undergo radical prostatectomy.
- Published
- 2019
- Full Text
- View/download PDF
8. The Prognosis and Oncological Predictor of Urachal Carcinoma of the Bladder: A Large Scale Multicenter Cohort Study Analyzed 203 Patients With Long Term Follow-Up
- Author
-
Young Dong Yu, Young Hwii Ko, Jong Wook Kim, Seung Il Jung, Seok Ho Kang, Jinsung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, and Jong Jin Oh
- Subjects
urachal carcinoma ,bladder ,survival rate ,surgical margin ,lymphovascular invasion ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
AimThis study evaluated the prognosis and survival predictors for bladder urachal carcinoma (UC), based on large scale multicenter cohort with long term follow-up database.MethodsA total 203 patients with bladder UC treated at 19 hospitals were enrolled. Clinical parameters on carcinoma presentation, diagnosis, and therapeutic methods were reviewed for the primary cancer and for all subsequent recurrences. The stage of UC was stratified by Mayo and Sheldon pathological staging system. Oncological outcomes and the possible clinicopathological parameters associated with survival outcomes were investigated.ResultsThe mean age of the patients was 54.2 years. Among the total of 203 patients, stages I, II, III, and IV (Mayo stage) were 48 (23.8%), 108 (53.5%), 23 (11.4%), and 23 (11.4%), respectively. Gross hematuria and bladder irritation symptoms were the two most common initial symptoms. The mean follow-up period was 65 months, and 5-year overall survival rates (OS), cancer-specific survival rates (CSS), and recurrence-free survival rates (RFS) were 88.3, 83.1, and 63.9%, respectively. For the patients with Mayo stage ≥III, OS, CSS, and RFS were significantly decreased to 38.0, 35.2, and 28.4%, respectively. The higher pathological stage (Mayo stage ≥III, Sheldon stage ≥IIIc), positive surgical margin (PSM), and positive lymphovascular invasion (PLM) were independent predictors of shorter OS, CSS, and RFS.ConclusionThe pathological stage, PSM, and PLM were significantly associated with the survival of UC patients, emphasizing an importance of the complete surgical resection of tumor lesion.
- Published
- 2021
- Full Text
- View/download PDF
9. Programmed Cell Death-Ligand 1 Expression Status in Urothelial Carcinoma According to Clinical and Pathological Factors: A Multi-Institutional Retrospective Study
- Author
-
Hyung Suk Kim, Won Sik Jang, Won Sik Ham, Seung Il Jung, Dong Hyun Lee, Ja Hyeon Ku, Hong Koo Ha, Ja Yoon Ku, Se Young Choi, In Ho Chang, Taesoo Choi, Wan Song, Seong Soo Jeon, Byong Chang Jeong, Sung Han Kim, and Ho Kyung Seo
- Subjects
urothelial carcinoma ,immune cell ,programmed cell death-ligand 1 ,immunohistochemistry ,immune checkpoint ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Purpose: To investigate programmed cell death-ligand 1 (PD-L1) expression status and the clinical and pathological factors related to its expression in urothelial carcinoma (UC) patients.Materials and Methods: Data from 761 UC patients who underwent testing for PD-L1 expression using the VENTANA (SP-142 immunohistochemistry assay) for measuring PD-L1 expression according to the manufacturer's protocol between February 2016 and July 2019 were retrospectively reviewed. Patients were categorized into three groups based on the percentage of tumor area covered by PD-L1-expressing tumor-infiltrating immune cells (ICs) as follows: IC0 (
- Published
- 2020
- Full Text
- View/download PDF
10. A Unique Urinary Metabolic Feature for the Determination of Bladder Cancer, Prostate Cancer, and Renal Cell Carcinoma
- Author
-
Sujin Lee, Ja Yoon Ku, Byeong Jin Kang, Kyung Hwan Kim, Hong Koo Ha, and Suhkmann Kim
- Subjects
urological cancer ,metabolomics ,NMR spectroscopy ,urine ,discriminant metabolites ,Microbiology ,QR1-502 - Abstract
Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most prevalent cancer among urological cancers. However, there are no cancer-specific symptoms that can differentiate them as well as early clinical signs of urological malignancy. Furthermore, many metabolic studies have been conducted to discover their biomarkers, but the metabolic profiling study to discriminate between these cancers have not yet been described. Therefore, in this study, we aimed to investigate the urinary metabolic differences in male patients with PCa (n = 24), BCa (n = 29), and RCC (n = 12) to find the prominent combination of metabolites between cancers. Based on 1H NMR analysis, orthogonal partial least-squares discriminant analysis was applied to find distinct metabolites among cancers. Moreover, the ranked analysis of covariance by adjusting a potential confounding as age revealed that 4-hydroxybenzoate, N-methylhydantoin, creatinine, glutamine, and acetate had significantly different metabolite levels among groups. The receiver operating characteristic analysis created by prominent five metabolites showed the great discriminatory accuracy with area under the curve (AUC) > 0.7 for BCa vs. RCC, PCa vs. BCa, and RCC vs. PCa. This preliminary study compares the metabolic profiles of BCa, PCa, and RCC, and reinforces the exploratory role of metabolomics in the investigation of human urine.
- Published
- 2021
- Full Text
- View/download PDF
11. Adrenal Castleman's Disease Mimicking Other Adrenal Neoplasms: A Case Report
- Author
-
Seung Baek Hong, Nam Kyung Lee, Suk Kim, Ga Jin Han, Hong Koo Ha, Ja Yoon Ku, Sang Jeong Ahn, and Chang Hun Lee
- Subjects
giant lymph noe hyperplsia ,adrenal glands ,multidetector computed tomography ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
We present a rare case of adrenal Castleman's disease with hyaline vascular type mimicking other adrenal neoplasms in a 65-year-old woman. Although rare, the hyaline vascular type of adrenal Castleman's disease should be included in the differential diagnosis if an adrenal mass shows a well-defined, highly enhancing solid adrenal mass with peripheral rim enhancement, multiple satellite lymph nodes, and peritoneal thickening around the dominant mass on computed tomography as shown in this patient.
- Published
- 2017
- Full Text
- View/download PDF
12. The Prognostic Impact of Angiolymphatic Invasion in Bladder Urothelial Carcinoma Patients Undergoing Radical Cystectomy
- Author
-
Jin Hyuck Kim, Young Hwii Ko, Jong Wook Kim, Seok Ho Kang, Seung Il Jung, Jin Sung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, and Jong Jin Oh
- Subjects
General Medicine - Abstract
Purpose: The aim of this study was to investigate the association between angiolymphatic invasion (ALI) and bladder cancer in patients who underwent radical cystectomy (RC).Materials and Methods: Multicenter retrospective data from 495 bladder cancer patients who underwent RC between 2007 and 2019 were enrolled in this study. Patients were stratified into 2 groups according to the presence of ALI. The effect of ALI was analyzed by the Kaplan-Meier method and Cox regression hazard models for patients’ cancer-specific survival (CSS), overall survival (OS), and recurrence-free survival (RFS).Results: The median age of the 495 patients in the study was 65 years, with median and mean follow-up durations of 23.3 months and 37.1 months, respectively. ALI was present in 182 patients (36.8%). ALI was significantly associated with worse RFS as well as CSS and OS (p
- Published
- 2023
13. TNM-Based Head-to-Head Comparison of Urachal Carcinoma and Urothelial Bladder Cancer: Stage-Matched Analysis of a Large Multicenter National Cohort.
- Author
-
Sang Hun Song, Jaewon Lee, Young Hwii Ko, Jong Wook Kim, Seung Il Jung, Seok Ho Kang, Jinsung Park, Ho Kyung Seo, Hyung Joon Kim, Byong Chang Jeong, Tae-Hwan Kim, Se Young Choi, Jong Kil Nam, Ja Yoon Ku, Kwan Joong Joo, Won Sik Jang, Young Eun Yoon, Seok Joong Yun, Sung-Hoo Hong, and Jong Jin Oh
- Subjects
BLADDER cancer ,TRANSITIONAL cell carcinoma ,SURVIVAL rate ,BODY mass index ,OVERALL survival ,SURVIVAL analysis (Biometry) - Abstract
Purpose Outcome analysis of urachal cancer (UraC) is limited due to the scarcity of cases and different staging methods compared to urothelial bladder cancer (UroBC). We attempted to assess survival outcomes of UraC and compare to UroBC after stage-matched analyses. Materials and Methods Total 203 UraC patients from a multicenter database and 373 UroBC patients in single institution from 2000 to 2018 were enrolled (median follow-up, 32 months). Sheldon stage conversion to corresponding TNM staging for UraC was conducted for head-to-head comparison to UroBC. Perioperative clinical variables and pathological results were recorded. Stage-matched analyses for survival by stage were conducted. Results UraC patients were younger (mean age, 54 vs. 67 years; p < 0.001), with 163 patients (80.3%) receiving partial cystectomy and 23 patients (11.3%) radical cystectomy. UraC was more likely to harbor ≥ pT3a tumors (78.8% vs. 41.8%). While 5-year recurrence-free survival, cancer-specific survival (CSS) and overall survival were comparable between two groups (63.4%, 67%, and 62.1% in UraC and 61.5%, 75.9%, and 67.8% in UroBC, respectively), generally favorable prognosis for UraC in lower stages (pT1-2) but unfavorable outcomes in higher stages (pT4) compared to UroBC was observed, although only 5-year CSS in ≥ pT4 showed statistical significance (p=0.028). Body mass index (hazard ratio [HR], 0.929), diabetes mellitus (HR, 1.921), pathologic T category (HR, 3.846), and lymphovascular invasion (HR, 1.993) were predictors of CSS for all patients. Conclusion Despite differing histology, UraC has comparable prognosis to UroBC with relatively favorable outcome in low stages but worse prognosis in higher stages. The presented system may be useful for future grading and risk stratification of UraC. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. MP08-09 Down-STAGING IN AUA RISK STRATIFICATION AFTER INTRAVESICAL BACILLUS CALMETTE-GUERIN THERAPY HAS FAVORABLE EFFECT ON RECURRENCE FREE SURVIVAL AFTER 2ND LINE INTRAVESICAL GEMCITABINE CHEMOTHERAPY
- Author
-
Kyung Hwan Kim, Byeong Jin Kang, Gwon Kyeong Lee, Wooseop Seong, Kyoungha Jang, Ja Yoon Ku, and Hong Koo Ha
- Subjects
Urology - Published
- 2023
15. Alix-Normalized Exosomal Pd-L1 Analysis in Urine Enables Precision Monitoring of Urothelial Cancer
- Author
-
Hyun-Kyung Woo, Juhee Park, Kyung Hwan Kim, Ja Yoon Ku, Hong Koo Ha, and Yoon-Kyoung Cho
- Published
- 2023
16. Clinical Significance of Rab27a as a Urinary Biomarker in Patients With Bladder Cancer
- Author
-
Ja Yoon Ku, Eu Chang Hwang, Chan Ho Lee, Kyung Hwan Kim, Dong Deuk Kwon, and Hong Koo Ha
- Subjects
endocrine system - Abstract
Purpose: The aims of this study were to investigate the clinical value of Rab27a as a urinary biomarker, and its efficiency in the prediction of bladder cancer grade.Materials and Methods: The expression of Rab27a in urine samples of patients with bladder cancer, cell line (T-24), and tissue samples of patients with bladder cancer was estimated via quantitative reverse transcription polymerase chain reaction (qRT-PCR). The Rab27a expression level was investigated according to sex, age, and histological grade via qRT-PCR and Western blotting.Results: Rab27a was also expressed at high levels in urine compared to cell lines and tissues from bladder cancer patients. In addition, Rab27a expression varied significantly according to tumor grade (p
- Published
- 2022
17. Effect of olfactory bulb atrophy on the success of olfactory training
- Author
-
Jeong Hyun Lee, Woo Ri Choi, Ji Heui Kim, Min Kyoung Lee, and Ja Yoon Ku
- Subjects
Olfactory system ,medicine.medical_specialty ,Gastroenterology ,Olfaction Disorders ,03 medical and health sciences ,0302 clinical medicine ,Atrophy ,Internal medicine ,medicine ,Humans ,Risk factor ,030223 otorhinolaryngology ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,medicine.disease ,Magnetic Resonance Imaging ,Olfactory Bulb ,Olfactory bulb ,Smell ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Etiology ,Neurosurgery ,business - Abstract
To evaluate the success of olfactory training in patients with olfactory loss and olfactory bulb (OB) atrophy detected on magnetic resonance imaging (MRI) and other characteristics. This study included 48 patients with olfactory loss who underwent a nasal endoscopic examination and MRI before olfactory training. The Korean Version of the Sniffin’ Sticks Test was performed before and after training. The olfactory training success was defined as an improvement of more than 6 points in the Threshold-Discrimination-Identification (TDI) score. Patient characteristics and OB atrophy pre-training were compared between successful and unsuccessful groups. The etiology of olfactory loss included respiratory viral infection in 30 (62.5%), trauma in 10 (20.8%), and idiopathic loss in 8 (16.7%) patients. Twenty-three (47.9%) of 48 patients exhibited successful olfactory training. Etiology, age, gender, and symptom duration were not different between unsuccessful and successful groups. Pre-training discrimination, identification, and TDI scores were significantly different between unsuccessful and successful groups (P
- Published
- 2021
18. Targeted therapy response in early versus late recurrence of renal cell carcinoma after surgical treatment: A propensity score‐matched study using the Korean Renal Cancer Study Group database
- Author
-
Cheryn Song, Hong Koo Ha, Minyong Kang, Jae Young Park, Eu Chang Hwang, Won Ik Seo, Cheol Kwak, Jinsoo Chung, Chan Ho Lee, Chang Wook Jeong, Seock Hwan Choi, Hakmin Lee, Sung-Hoo Hong, Ja Yoon Ku, and Seong Il Seo
- Subjects
medicine.medical_specialty ,Lymphovascular invasion ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Gastroenterology ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,Republic of Korea ,Late Recurrence ,medicine ,Humans ,Propensity Score ,Surgical treatment ,Carcinoma, Renal Cell ,Retrospective Studies ,business.industry ,Hazard ratio ,Cancer ,Prognosis ,medicine.disease ,Kidney Neoplasms ,030220 oncology & carcinogenesis ,Propensity score matching ,Neoplasm Recurrence, Local ,business - Abstract
OBJECTIVES: To investigate the clinicopathological features and outcomes of targeted therapy in patients with recurrence of renal cell carcinoma in
- Published
- 2021
19. Prognostic significance of sarcopenia and decreased relative dose intensity during the initial two cycles of first-line sunitinib for metastatic renal cell carcinoma
- Author
-
Jae Il Chung, Young Joo Park, Wansuk Kim, Won Ik Seo, Tae Yong Park, Ja Yoon Ku, Hong Koo Ha, and Chan Ho Lee
- Subjects
Adult ,0301 basic medicine ,Oncology ,Sarcopenia ,medicine.medical_specialty ,medicine.medical_treatment ,First line ,030106 microbiology ,Antineoplastic Agents ,urologic and male genital diseases ,Targeted therapy ,03 medical and health sciences ,0302 clinical medicine ,Renal cell carcinoma ,Internal medicine ,Sunitinib ,medicine ,Humans ,Pharmacology (medical) ,Carcinoma, Renal Cell ,Aged ,Retrospective Studies ,Aged, 80 and over ,Pharmacology ,Dose-Response Relationship, Drug ,business.industry ,fungi ,Therapeutic effect ,food and beverages ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Dose intensity ,Kidney Neoplasms ,humanities ,body regions ,Infectious Diseases ,030220 oncology & carcinogenesis ,business ,medicine.drug - Abstract
Targeted therapy for metastatic renal cell carcinoma (mRCC) treatment requires the identification of clinically important factors that can predict the therapeutic effect. We retrospectively investigated the prognostic roles of pre-treatment sarcopenia and relative dose intensity during the initial two cycles (2c-RDI) of sunitinib treatment in patients with mRCC. In total, 41 (52.6%) patients were classified as having sarcopenia and 16 (20.5%) patients were classified with low 2c-RDI at75%. The mean dose reduction during sunitinib treatment was higher for sarcopenic than for non-sarcopenic patients. The median progression-free survival (PFS) and overall survival (OS) were significantly shorter in sarcopenic patients with low 2c-RDI (n = 14, 17.9%) than in non-sarcopenic patients with high 2c-RDI (n = 35, 44.9%). Multivariate analysis identified sarcopenia and low 2c-RDI as poor prognostic factors for PFS and OS. Our findings provide new insights into the prognostic role of sarcopenia and 2c-RDI for targeted therapy in mRCC.
- Published
- 2021
20. Clinical factors that influence the occurrence of symptomatic pseudoaneurysms and arteriovenous fistulas after partial nephrectomy: multi-institutional study of renal function outcomes after one year of selective arterial embolization
- Author
-
Seock Hwan Choi, Ja Yoon Ku, Won Ik Seo, Chan Ho Lee, and Hong Koo Ha
- Subjects
medicine.medical_specialty ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Renal function ,Arteriovenous fistula ,Collection system ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,parasitic diseases ,medicine ,Humans ,cardiovascular diseases ,Renal artery ,Renal sinus ,Retrospective Studies ,business.industry ,Arterial Embolization ,Odds ratio ,medicine.disease ,Kidney Neoplasms ,Diseases of the genitourinary system. Urology ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Arteriovenous Fistula ,Original Article ,RC870-923 ,business ,Aneurysm, False ,Glomerular Filtration Rate - Abstract
Purpose: Renal artery pseudoaneurysms (RAPs) and arteriovenous fistulas (AVFs) are rare but potentially life-threatening complications after partial nephrectomy (PN). Selective arterial embolization (SAE) is an effective method for controlling RAPs/AVFs. We assessed the clinical factors affecting the occurrence of RAPs/AVFs after PN and the effects of SAE on postsurgical renal function. Materials and Methods: Four hundred ninety-three patients who underwent PN were retrospectively reviewed. They were placed in either the SAE or the non-SAE group. The effects of clinical factors, including R.E.N.A.L. scores, on the occurrence of RAPs/AVFs were analyzed. The influence of SAE on the estimated glomerular filtration rate (eGFR) during the first postoperative year was evaluated. Results: Thirty-three (6.7%) patients experienced RAPs/AVFs within 8 days of the median interval between PN and SAE. The SAE group had significantly higher R.E.N.A.L. scores, higher N component scores, and higher L component scores (all, p
- Published
- 2020
21. Risk Factors for pT3a Prostate Cancer in the Patients With cT1-2 on Preoperative Multiparametric Magnetic Resonance Imaging
- Author
-
Suk Kim, Seung Baek Hong, Ja Yoon Ku, Kyung Hwan Kim, Won Young Park, and Hong Koo Ha
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Prostatectomy ,medicine.medical_treatment ,Magnetic resonance imaging ,medicine.disease ,Prostate cancer ,Biopsy ,medicine ,Tumor Grading ,Radiology ,Ultrasonography ,business ,Multiparametric Magnetic Resonance Imaging - Published
- 2020
22. Korean Translation of the GRADE Series Published in theBMJ, ‘GRADE: Grading Quality of Evidence and Strength of Recommendations for Diagnostic Tests and Strategies’ (A Secondary Publication)
- Author
-
Hyun Jin Jung, Ja Yoon Ku, Hong Wook Kim, Jae Hung Jung, Eu Chang Hwang, Do Kyung Kim, and Ho Won Kang
- Subjects
Quality of evidence ,medicine.medical_specialty ,business.industry ,medicine ,Diagnostic test ,Medical physics ,General Medicine ,business ,Grading (education) - Published
- 2020
23. Is it worth carrying out ultrasound–magnetic resonance imaging fusion targeted biopsy on Prostate Imaging Reporting and Data System score 3 prostate lesions?
- Author
-
Suk Kim, Kyung Hwan Kim, Seung Baek Hong, Won Young Park, Ja Yoon Ku, and Hong Koo Ha
- Subjects
Image-Guided Biopsy ,Male ,medicine.medical_specialty ,Urology ,030232 urology & nephrology ,Targeted biopsy ,03 medical and health sciences ,Prostate cancer ,0302 clinical medicine ,Prostate ,Biopsy ,medicine ,Humans ,Ultrasonography, Interventional ,Fusion Biopsy ,Prostate cancer risk ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Prostatic Neoplasms ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Radiology ,business - Abstract
OBJECTIVES To evaluate the use of ultrasound-magnetic resonance imaging fusion targeted biopsy for Prostate Imaging Reporting and Data System 3 prostate lesions. METHODS We identified 227 patients with prostate-specific antigen levels ≥4 ng/mL who underwent concurrent transrectal ultrasound-guided systemic biopsy and fusion biopsy. Suspicious prostatic lesions were assessed in accordance with Prostate Imaging Reporting and Data System version 2.0. We compared ultrasound-magnetic resonance imaging fusion targeted biopsy and ultrasound-guided biopsy cancer detection rates in Prostate Imaging Reporting and Data System 3 lesions with those in other Prostate Imaging Reporting and Data System score lesions. In Prostate Imaging Reporting and Data System 3 patients, we identified clinically significant prostate cancer risk factors by logistic regression analysis. RESULTS In total, 2770 transrectal ultrasound-guided and 867 fusion biopsy cores were obtained; where 332 (12.0%) and 194 (22.4%) cores were prostate cancer-positive, respectively (P
- Published
- 2020
24. Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice
- Author
-
Hyun Jun Park, Bo Sun Joo, Minjung Park, Ja Yoon Ku, and Nam Cheol Park
- Subjects
Male ,endocrine system ,0211 other engineering and technologies ,Panax ,Motility ,02 engineering and technology ,030226 pharmacology & pharmacy ,Andrology ,Mice ,03 medical and health sciences ,Follicle-stimulating hormone ,0302 clinical medicine ,Republic of Korea ,021105 building & construction ,medicine ,Animals ,Pharmacology (medical) ,Spermatogenesis ,Sperm motility ,Testosterone ,Plant Extracts ,Chemistry ,Water ,General Medicine ,Epididymis ,Sperm ,Mice, Inbred C57BL ,medicine.anatomical_structure ,Complementary and alternative medicine ,Sperm Motility ,Luteinizing hormone ,Hydrogen - Abstract
To investigate the effect of hydrogen-rich Korean Red Ginseng (KRG) water (HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Eighty young (3 month-old) and aged (12 month-old) male mice were randomly assigned to 4 groups (n =10 per group) including control group, hydrogen-rich water (HRW) group (10 mL/kg daily), KRG group (50 mg/kg daily) and HRGW group (10 mL/kg and 50 mg/kg daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and reactive oxygen species (ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation (PPx3, PPx4, GSTm5 and GPx4), spermatogenesis (inhibin-a, neptin-2 and CREM), antiaging (SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor (VEGF)] related genes were examined through real-time polymerase chain reaction. HRW and KRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility (P
- Published
- 2020
25. MP05-06 DIAGNOSTIC ACCURACY OF ADC VALUE ON BIPARAMETRIC MRI FOR DETECTING CLINICALLY SIGNIFICANT PROSTATE CANCER
- Author
-
Ja Yoon Ku, Jih Hoon Park, and Hong Koo Ha
- Subjects
Prostate cancer ,medicine.medical_specialty ,business.industry ,Urology ,Medicine ,Diagnostic accuracy ,Radiology ,business ,medicine.disease ,Value (mathematics) - Abstract
INTRODUCTION AND OBJECTIVE:PI-RADS v2 is helpful for the detection of clinically significant prostate cancer (CS-PCa), but does not provide quantitative information. We conducted this study to eval...
- Published
- 2021
26. MP05-02 PI-RADS 4 AND 5 LESIONS ARE THE RISK FACTORS FOR BIOCHEMICAL RECURRENCE IN THE LOW-INTERMEDIATE RISK PROSTATE CANCER
- Author
-
Ja Yoon Ku, Gwon Kyeong Lee, Kyung Hwan Kim, Byeong Jin Kang, Si Kyun Park, and Hong Koo Ha
- Subjects
Oncology ,PI-RADS ,Biochemical recurrence ,medicine.medical_specialty ,Prostate cancer ,business.industry ,Urology ,Internal medicine ,medicine ,Intermediate risk ,medicine.disease ,business - Published
- 2021
27. A Unique Urinary Metabolic Feature for the Determination of Bladder Cancer, Prostate Cancer, and Renal Cell Carcinoma
- Author
-
Hong Koo Ha, Ja Yoon Ku, Su Jin Lee, Suhkmann Kim, Byeong Jin Kang, and Kyung Hwan Kim
- Subjects
Oncology ,discriminant metabolites ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Urinary system ,Malignancy ,urologic and male genital diseases ,Microbiology ,Biochemistry ,Article ,Prostate cancer ,chemistry.chemical_compound ,NMR spectroscopy ,urological cancer ,metabolomics ,urine ,Renal cell carcinoma ,Internal medicine ,medicine ,Molecular Biology ,Creatinine ,Bladder cancer ,business.industry ,Area under the curve ,Cancer ,medicine.disease ,QR1-502 ,chemistry ,business - Abstract
Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most prevalent cancer among urological cancers. However, there are no cancer-specific symptoms that can differentiate them as well as early clinical signs of urological malignancy. Furthermore, many metabolic studies have been conducted to discover their biomarkers, but the metabolic profiling study to discriminate between these cancers have not yet been described. Therefore, in this study, we aimed to investigate the urinary metabolic differences in male patients with PCa (n = 24), BCa (n = 29), and RCC (n = 12) to find the prominent combination of metabolites between cancers. Based on 1H NMR analysis, orthogonal partial least-squares discriminant analysis was applied to find distinct metabolites among cancers. Moreover, the ranked analysis of covariance by adjusting a potential confounding as age revealed that 4-hydroxybenzoate, N-methylhydantoin, creatinine, glutamine, and acetate had significantly different metabolite levels among groups. The receiver operating characteristic analysis created by prominent five metabolites showed the great discriminatory accuracy with area under the curve (AUC) > 0.7 for BCa vs. RCC, PCa vs. BCa, and RCC vs. PCa. This preliminary study compares the metabolic profiles of BCa, PCa, and RCC, and reinforces the exploratory role of metabolomics in the investigation of human urine.
- Published
- 2021
28. Osteoporosis: Is it really a side effect of ADT?
- Author
-
G.K. Lee, J.G. Lee, Juhyun Park, S.K. Park, Hong Koo Ha, Ja Yoon Ku, B.J. Kang, and K.H. Kim
- Subjects
medicine.medical_specialty ,Side effect ,business.industry ,Urology ,Internal medicine ,Osteoporosis ,Medicine ,business ,medicine.disease - Published
- 2019
29. Relationship between Video Head Impulse Gain and Severity of Dizziness in Patients with Vestibular Neuritis
- Author
-
Hong Ju Park, Yong Han Kim, Woo Ri Choi, Ja Yoon Ku, Yehree Kim, and Sung Hoon Nam
- Subjects
medicine.medical_specialty ,Otorhinolaryngology ,Corrective saccade ,business.industry ,Medicine ,Vestibular neuritis ,Surgery ,In patient ,Head impulse test ,Audiology ,business - Published
- 2019
30. Comparison of Aided and Unaided Thresholds and Selection Processes of Contralateral Routing of Signal Hearing Aids and Implantable Bone Conduction Devices in Patients with Asymmetric Hearing Loss
- Author
-
Ja Yoon Ku, Mi Rye Bae, Chol Shin, Yong Han Kim, Ho-Jun Lee, and Hong Ju Park
- Subjects
medicine.medical_specialty ,Hearing loss ,business.industry ,Asymmetric hearing loss ,Audiology ,Signal ,Bone conduction ,Otorhinolaryngology ,medicine ,Surgery ,In patient ,medicine.symptom ,Routing (electronic design automation) ,business ,Selection (genetic algorithm) - Published
- 2019
31. Hearing Outcomes of Stapes Surgery in Children With Stapes Fixation and Ossicular Anomalies
- Author
-
Joong Ho Ahn, Ja Yoon Ku, Jong Woo Chung, Byung Chul Kang, and Hong Ju Park
- Subjects
medicine.medical_specialty ,Hearing loss ,Incus ,Stapes Surgery ,Bone conduction ,Hearing ,otorhinolaryngologic diseases ,medicine ,Humans ,Stapes fixation ,Child ,Retrospective Studies ,Fixation (histology) ,business.industry ,Retrospective cohort study ,Perioperative ,Stapes ,Sensory Systems ,Stapes surgery ,Surgery ,Ossicular Prosthesis ,Treatment Outcome ,Otorhinolaryngology ,Neurology (clinical) ,medicine.symptom ,business ,Bone Conduction - Abstract
OBJECTIVES To investigate hearing outcomes after stapes surgery in children with stapes fixation. STUDY DESIGN Retrospective study. SETTING Tertiary referral center. PATIENTS Forty-nine patients (66 ears) aged less than 15 years who received stapes surgery. INTERVENTIONS Stapes surgery. MAIN OUTCOMES AND MEASURES Preoperative symptoms, bilateral involvement, pure-tone hearing levels, and perioperative complications were analyzed using paired t test and Mann-Whitney U test. RESULTS The chief complaint of all patients was hearing disturbance. Sixteen ears were diagnosed with stapes fixation and an additional congenital ossicular anomaly and 50 ears had only stapes fixation. Preoperative mean bone conduction and air conduction thresholds were 12.0 ± 5.8 dB and 60.9 ± 10.9 dB, respectively. The mean air-bone gap (ABG) was 48.9 ± 12.0 dB in patients with stapes fixation and an ossicular anomaly. The postoperative mean ABG was 23.6 ± 14.5 dB, and the ABG closure was 25.3 ± 18.2 dB. In patients with stapes fixation only, the preoperative mean bone conduction and air conduction thresholds were 14.3 ± 7.5 dB and 49.6 ± 9.5 dB, respectively, and the mean ABG was 35.5 ± 9.6 dB. The postoperative mean ABG was 14.4 ± 10.3 dB, and the ABG closure was 16.2 ± 16.1 dB. The successful results (ABG
- Published
- 2021
32. Programmed Cell Death-Ligand 1 Expression Status in Urothelial Carcinoma According to Clinical and Pathological Factors: A Multi-Institutional Retrospective Study
- Author
-
Hong Koo Ha, Seung Il Jung, Byong Chang Jeong, Won Sik Ham, In Ho Chang, Dong Hyun Lee, Se Young Choi, Ja Hyeon Ku, Wan Song, Sung-Han Kim, Won Sik Jang, Hyung Suk Kim, Ja Yoon Ku, Taesoo Choi, Ho Kyung Seo, and Seong Soo Jeon
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Logistic regression ,programmed cell death-ligand 1 ,lcsh:RC254-282 ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Stage (cooking) ,immune checkpoint ,urothelial carcinoma ,Original Research ,business.industry ,Retrospective cohort study ,Odds ratio ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Confidence interval ,Clinical trial ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cohort ,immunohistochemistry ,Biomarker (medicine) ,immune cell ,business - Abstract
Purpose: To investigate programmed cell death-ligand 1 (PD-L1) expression status and the clinical and pathological factors related to its expression in urothelial carcinoma (UC) patients.Materials and Methods: Data from 761 UC patients who underwent testing for PD-L1 expression using the VENTANA (SP-142 immunohistochemistry assay) for measuring PD-L1 expression according to the manufacturer's protocol between February 2016 and July 2019 were retrospectively reviewed. Patients were categorized into three groups based on the percentage of tumor area covered by PD-L1-expressing tumor-infiltrating immune cells (ICs) as follows: IC0 (
- Published
- 2020
33. Comparison of allergens and symptoms in patients with allergic rhinitis between 1990s and 2010s
- Author
-
Shin Ae Kim, Ja Yoon Ku, Chol Ho Shin, Won Ki Cho, and Ji Heui Kim
- Subjects
lcsh:Immunologic diseases. Allergy ,Allergic Rhinitis ,medicine.medical_specialty ,Allergy ,Epidemiology ,medicine.disease_cause ,Allergen ,Internal medicine ,otorhinolaryngologic diseases ,medicine ,Sore throat ,Sensitization ,Nose ,biology ,business.industry ,Research ,General Medicine ,Allergens ,Alternaria ,biology.organism_classification ,medicine.disease ,medicine.anatomical_structure ,Itching ,medicine.symptom ,lcsh:RC581-607 ,business - Abstract
Background The prevalence of allergic rhinitis (AR), an environment- and lifestyle-dependent condition, has been constantly increasing in Korea. Although the environment and lifestyle of the Korean people have recently undergone rapid changes, corresponding changes in the characteristics of AR patients have not been well documented. Therefore, we aimed to outline the changes in allergens and clinical manifestations of AR in Korean patients from the 1990s and 2010s. Methods We reviewed 1447 and 3388 AR patients who visited the same tertiary hospital in the 1990s and 2010s, respectively. All patients were diagnosed with AR based on the presence of characteristic symptoms, positive skin prick test results, and answered a symptom questionnaire at the time of visit. We compared differences in the allergens and results of the symptom questionnaire between the two sets of patients. Results When compared with the 1990s, the rate of sensitization to house dust mites, cockroaches, Aspergillus, Alternaria, and tree pollen significantly increased and that to cat fur significantly decreased in patients from the 2010s (all P P P Conclusions Allergen reactivity and type and symptom severity in Korean AR patients significantly varied between the 1990s and 2010s. Our results may therefore be helpful for patient counseling and management.
- Published
- 2020
34. Risk factors for survival of head and neck soft tissue sarcomas: A comparison between 7th and 8th edition AJCC staging systems
- Author
-
Kyung-Ja Cho, Ja Yoon Ku, Soon Yuhl Nam, Seung-Ho Choi, Joon Seon Song, Sang Yoon Kim, and Jong-Lyel Roh
- Subjects
Oncology ,Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Kaplan-Meier Estimate ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Risk Factors ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,030223 otorhinolaryngology ,Head and neck ,Child ,Neoplasm Staging ,Chemotherapy ,business.industry ,Soft tissue ,Cancer ,Sarcoma ,Ajcc staging ,Middle Aged ,medicine.disease ,Prognosis ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Resection margin ,Female ,Oral Surgery ,business ,Chemoradiotherapy - Abstract
Soft tissue sarcomas of the head and neck (HNSTS) show various histological types and clinical behaviour. Recently, the 8th edition of the American Joint Committee on Cancer (AJCC) proposed a staging system for HNSTS independent of other body soft tissue sarcomas, which requires validation. Therefore, we evaluated the prognostic factors for the survival of HNSTS patients through a comparison between previous and current AJCC staging systems.This study involved 135 consecutive HNSTS patients who underwent primary surgery, chemoradiotherapy or chemotherapy. Patients were grouped into staged (S) and not staged (NS) cancer according to the AJCC 8th edition staging. Cox proportional-hazard regression analyses were used to identify factors associated with overall survival (OS), and progression-free survival (PFS) in all, S or NS patients.Median follow-up period was 75 months and the 5-year OS and PFS rates of all patients were 67.8% and 53.4%, respectively, which was similar between S and NS groups. Age, tumour size and grade, overall stage (7th edition) and resection margin were the significant prognostic factors for OS and PFS in all patients and NS group (all P 0.05), whereas positive resection margin was the only significant factor for OS and PFS in the S group (P 0.001). While OS was poorly discriminated among different 8th edition T-categories, different 7th edition showed good discrimination among overall stages in all patients and the NS group.The revised staging system may not provide an improved risk stratification for survival of HNSTS patients.
- Published
- 2019
35. Clinical Application of a Transurethral Holmium Laser Excision of Exposed Polypropylene Mesh at Lower Urinary Tract: Single Surgeon Experience With Long-term Follow-up
- Author
-
Ja Yoon Ku, Jeong Zoo Lee, Dong Gil Shin, Kyoung Lee, and Chan Ho Lee
- Subjects
Adult ,Stress incontinence ,medicine.medical_specialty ,Sling (implant) ,Urinary Incontinence, Stress ,Urology ,Urinary system ,030232 urology & nephrology ,Urinary incontinence ,Lasers, Solid-State ,Polypropylenes ,Pelvic Organ Prolapse ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,medicine ,Humans ,Minimally Invasive Surgical Procedures ,Aged ,Retrospective Studies ,Suburethral Slings ,030219 obstetrics & reproductive medicine ,business.industry ,Obstetrics and Gynecology ,Surgical wound ,Retrospective cohort study ,Middle Aged ,Surgical Mesh ,medicine.disease ,Surgery ,Polypropylene mesh ,Treatment Outcome ,Feasibility Studies ,Female ,medicine.symptom ,Complication ,business ,Follow-Up Studies - Abstract
Purpose The aim of this study was to evaluate the clinical application of a transurethral holmium laser excision of exposed polypropylene mesh as an effective minimally invasive surgical approach in patients with lower urinary tract mesh erosion following the transvaginal placement of polypropylene mesh. Methods A retrospective analysis was conducted on the data of 22 patients with exposed polypropylene mesh in the lower urinary tract that was managed using the transurethral holmium laser technique. The patients were divided into 2 groups based on the type of mesh surgery: a midurethral sling (MUS) group (n = 18) and a pelvic organ prolapse (POP) group (n = 4). The surgical outcomes were compared. Results The mean time follow-up after the first surgery was 23.2 months, and 14 patients (64%) reported symptomatic improvement. During outpatient follow-up, eroded residual mesh and failed re-epithelialization were discovered in 6 patients. The recurrence rates in the MUS and POP groups after the first surgery were 22% and 50%, respectively. The recurrence-free periods of each group were 30.5 versus 13.5 months, respectively. Whereas 5 patients had successful epithelialization of the surgical wound following the second endoscopic surgery, 1 patient in the POP group required a third endoscopic surgery because of persistent mesh erosion. Conclusions The excision of exposed polypropylene mesh using a transurethral holmium laser following MUS appears to be a feasible option because of potentially low rates of complication and recurrent stress incontinence. However, minimally invasive approach using holmium laser may not be as successful for mesh erosion after transvaginal mesh repair for POP.
- Published
- 2018
36. A Case of the Ex Utero Intrapartum Treatment (EXIT) in Congenital High Airway Obstruction Syndrome (CHAOS)
- Author
-
Ja Yoon Ku, Yoon Se Lee, Seung Cheol Ha, and Young-Ha Lee
- Subjects
Chaos (genus) ,medicine.medical_specialty ,biology ,In utero ,business.industry ,Internal medicine ,Cardiology ,Medicine ,Airway obstruction ,biology.organism_classification ,business ,medicine.disease - Published
- 2017
37. Predictors for Intravesical Recurrence Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A National Multicenter Analysis
- Author
-
Chang Wook Jeong, Seock Hwan Choi, Hyun Tae Kim, Tae-Hwan Kim, Hong Koo Ha, Hyeon Hoe Kim, Tae Gyun Kwon, Dong Deuk Kwon, Chan Ho Lee, Taek Won Kang, Ja Hyeon Ku, Ja Yoon Ku, Cheol Kwak, Seung Il Jung, Eu Chang Hwang, and Bum Sik Tae
- Subjects
Male ,medicine.medical_specialty ,Urology ,Urinary system ,030232 urology & nephrology ,Nephroureterectomy ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Cytology ,Cox proportional hazards regression ,medicine ,Humans ,In patient ,Hydronephrosis ,Aged ,Urothelial carcinoma ,Carcinoma, Transitional Cell ,Tumor size ,business.industry ,Middle Aged ,medicine.disease ,Survival Analysis ,Treatment Outcome ,Urinary Bladder Neoplasms ,Oncology ,Upper tract ,030220 oncology & carcinogenesis ,Regression Analysis ,Female ,Neoplasm Recurrence, Local ,business - Abstract
The purpose of this study was to identify the prognostic impact of intravesical recurrence (IVR) on oncologic outcomes and the clinicopathologic factors that predict IVR in patients who undergo radical nephroureterectomy (RNU) for upper tract urothelial carcinoma.Between January 2000 and December 2015, 760 patients with upper tract urothelial carcinoma underwent RNU at 5 institutions in Korea, and patient data were retrospectively collected. Clinicopathologic factors were analyzed for intravesical recurrence-free survival, cancer-specific survival (CSS), and overall survival (OS). Univariate and multivariate Cox proportional hazards regression models were used to test the clinicopathologic factors on IVR.Of the 760 patients, 231 (30.3%) patients experienced IVR within 10 months of the median interval between RNU and the first IVR. The overall estimated probabilities of 5-year CSS, intravesical recurrence-free survival, and OS were 84.2%, 63.8%, and 79.2%, respectively. No difference was noted in terms of CSS and OS between the patients who did or did not experience IVR. The multivariate Cox analysis showed an association between IVR and positive hydronephrosis, tumor size, positive preoperative urinary cytology, and ureterorenoscopy before RNU (all P .05). However, a significantly decreased risk of IVR was associated with female gender, laparoscopic RNU, and receipt of adjuvant systemic chemotherapy (all P .05).The occurrence of IVR following RNU did not affect CSS and OS. Patients with larger tumor size, preoperative hydronephrosis, positive preoperative urinary cytology, and ureterorenoscopy before RNU had a higher risk of IVR following RNU.
- Published
- 2017
38. Radiological tumor thickness as a risk factor for local recurrence in early glottic cancer treated with laser cordectomy
- Author
-
Yoon Se Lee, Ja Yoon Ku, Sang Yoon Kim, Jong-Lyel Roh, Soon Yuhl Nam, Ho-Jin Son, and Seung-Ho Choi
- Subjects
Adult ,Male ,Glottis ,Microsurgery ,medicine.medical_specialty ,Anterior commissure ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,medicine ,Humans ,Transoral laser microsurgery ,Stage (cooking) ,030223 otorhinolaryngology ,Laryngeal Neoplasms ,Survival rate ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Univariate analysis ,business.industry ,General Medicine ,Middle Aged ,Prognosis ,Survival Analysis ,Glottic Squamous Cell Carcinoma ,Surgery ,Survival Rate ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Cordectomy ,Female ,Laser Therapy ,Radiology ,Neoplasm Recurrence, Local ,Tomography, X-Ray Computed ,business ,Follow-Up Studies - Abstract
Despite the excellent prognosis of early glottic cancer (T1-T2), the significance of preoperatively measured tumor thickness has not been elucidated. We evaluated the role of tumor thickness measured using computed tomography (CT) as a predictive factor for recurrence of early glottic cancer after transoral laser microsurgery (TLM).The medical records of 134 patients who were diagnosed with early glottic squamous cell carcinoma and underwent TLM were reviewed. Age, sex, clinical stage, preoperative biopsy, anterior commissure involvement, CT findings, recurrence, and overall survival were evaluated.Seventy-three patients (54 T1a, 2 T1b, and 17 T2) were enrolled. Tumor thickness on pathology increased proportionally with increased tumor thickness on CT. The recurrence-free survival (RFS) and overall survival rates were 82.2 and 91.2%, respectively. Upon univariate analysis, RFS was affected by the type of cordectomy, tumor differentiation, margin involvement, anterior commissure involvement, impaired vocal fold mobility, and tumor thickness ( 4 mm) on CT scan (all p 0.01). Among the relevant covariates, an involved or close resection margin [hazard ratio (HR) 19.2; 95% confidence interval (CI) 3.5-105.6; p 0.01], impaired vocal cord mobility (HR 8.5; 95% CI 1.45-49.2; p = 0.02), and pathological tumor thickness ( 4 mm) (HR 6.0; p = 0.02) were predictive of RFS.Tumor thickness may be another predictive factor for recurrence in early glottic cancer. Before TLM, reviewing the extent of tumor thickness will help to improve local control in cases of early glottic cancer.
- Published
- 2017
39. MP20-15 INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY GRADE MIGRATION IN THE PROSTATE CANCER PATIENTS
- Author
-
Gwon Kyeong Lee, Sang Don Lee, Jih Hoon Park, Ja Yoon Ku, Byeong Jin Kang, Kyung Hwan Kim, Si Kyun Park, and Hong Koo Ha
- Subjects
medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Urology ,Ultrasound ,Magnetic resonance imaging ,medicine.disease ,Ultrasound guided ,Prostate cancer ,Biopsy ,Medicine ,Radiology ,business ,Fusion Biopsy - Published
- 2020
40. The cumulative incidence and risk factor of postoperative inguinal hernia in patient undergone radical prostatectomy
- Author
-
Juhyun Park, K.H. Kim, B.J. Kang, S.K. Park, Hong Koo Ha, G.K. Lee, and Ja Yoon Ku
- Subjects
medicine.medical_specialty ,Inguinal hernia ,Prostatectomy ,business.industry ,Urology ,medicine.medical_treatment ,medicine ,In patient ,Cumulative incidence ,Risk factor ,medicine.disease ,business ,Surgery - Published
- 2019
41. Vesical Imaging-Reporting and Data System for Multiparametric MRI to Predict the Presence of Muscle Invasion for Bladder Cancer
- Author
-
Suk Kim, Nam Kyung Lee, Seung Baek Hong, Kyung Hwan Kim, Il Wan Son, Won Young Park, Hong Koo Ha, and Ja Yoon Ku
- Subjects
Male ,medicine.medical_specialty ,Population ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Stage (cooking) ,Multiparametric Magnetic Resonance Imaging ,education ,Retrospective Studies ,education.field_of_study ,Bladder cancer ,Urinary bladder ,medicine.diagnostic_test ,business.industry ,Muscles ,Area under the curve ,Multiparametric MRI ,Prostatic Neoplasms ,Magnetic resonance imaging ,medicine.disease ,Confidence interval ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Radiology ,business - Abstract
BACKGROUND The Vesical Imaging-Reporting and Data System (VI-RADS) is a newly developed system of bladder cancer staging with multiparametric MRI (mpMRI), which can be used to predict the presence of muscle invasion for bladder cancer. PURPOSE To evaluate the accuracy of three mpMRI series (T2 WI, diffusion-weighted imaging [DWI], and dynamic contrast-enhanced image [DCEI]) and VI-RADS for diagnosing the muscle invasive bladder cancer (MIBC). STUDY TYPE Retrospective. POPULATION In all, 66 pathologically proven bladder cancers in 32 patients. FIELD STRENGTH/SEQUENCE Before the diagnostic MRI with an intramuscular antispasmodic agent, optimal bladder distension was confirmed. 3.0T MRI with T2 WI, DWI, and DCEI. ASSESSMENT Three reviewers independently assessed and scored the bladder cancers in T2 WI, DWI, and DCEI using a five-point score system. Based on the scores in the three sequences, reviewers scored each bladder cancer with reference to VI-RADS categories. We evaluated the diagnostic performance of each of three mpMRI sequences and the final VI-RADS categorization for diagnosing MIBC. STATISTICAL TESTS Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and the area under the curve (AUC) of each of three sequences separately and VI-RADS categorization for diagnosing the MIBC. RESULTS The diagnostic performances of each of the three mpMRI series and VI-RADS for diagnosing MIBC were excellent. Especially using the optimal cutoff score >3 for predicting MIBC on DWI, DCEI, and VI-RADS, the sensitivity, specificity, PPV, NPV, and AUC values were 90% (95% confidence interval [CI]: 0.56, 1.00), 100% (95% CI: 0.94, 1.00), 100% (95% CI: 0.66. 1.00), 98.3% (95% CI: 0.91, 1.00), and 0.95, respectively. DATA CONCLUSION: mpMRI based on VI-RADS can stratify patients with bladder cancer according to the presence of muscle invasion. LEVEL OF EVIDENCE 3. TECHNICAL EFFICACY STAGE 2. J. Magn. Reson. Imaging 2020;52:1249-1256.
- Published
- 2019
42. The superiority of contact surface area as a predictor of renal cortical volume change after partial nephrectomy compared to RENAL, PADUA and C-index: an approach using computed tomography-based renal volumetry
- Author
-
Won Ik Seo, Young Joo Park, Chan Ho Lee, Hong Koo Ha, and Ja Yoon Ku
- Subjects
Adult ,Male ,Kidney Cortex ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Blood Loss, Surgical ,Computed tomography ,030204 cardiovascular system & hematology ,urologic and male genital diseases ,Cortical volume ,Nephrectomy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Carcinoma, Renal Cell ,Aged ,Aged, 80 and over ,integumentary system ,medicine.diagnostic_test ,business.industry ,Nephrons ,Organ Size ,Middle Aged ,Predictive value ,Kidney Neoplasms ,Nephrology ,Linear Models ,Female ,sense organs ,Nephron sparing surgery ,Nuclear medicine ,business ,Tomography, X-Ray Computed ,Organ Sparing Treatments ,Glomerular Filtration Rate - Abstract
Objective: To evaluate the renal cortical volume (RCV) change after nephron sparing surgery and the predictive value of the nephrometry score in RCV preservation after partial nephrectomy.Materials...
- Published
- 2019
43. MP13-04 ANALYSIS ON THE EVIDENCE OF ULTRASOUND-MRI FUSION TARGET BIOPSY ON PI-RADS SCORE 3 PROSTATE LESIONS
- Author
-
Seung Baek Hong, Suk Kim, Jih Hoon Park, Won Young Park, Hong Koo Ha, Ja Yoon Ku, Seung Ryong Baek, Kyung Hwan Kim, Byeong Jin Kang, and Si Kyun Park
- Subjects
PI-RADS ,medicine.medical_specialty ,medicine.anatomical_structure ,medicine.diagnostic_test ,business.industry ,Prostate ,Urology ,Biopsy ,Ultrasound ,medicine ,Radiology ,business - Abstract
INTRODUCTION AND OBJECTIVES:To evaluate the evidence of ultrasound-MRI fusion target biopsy on PI-RADS score 3 prostate lesionsMETHODS:Between October, 2016 and July, 2018, 151 patients underwent u...
- Published
- 2019
44. Prognostic value of neutrophil-to-lymphocyte ratio in older patients with head and neck cancer
- Author
-
Seung-Ho Choi, Soon Yuhl Nam, Sung-Bae Kim, Jong-Lyel Roh, Ja Yoon Ku, and Sang Yoon Kim
- Subjects
Oncology ,medicine.medical_specialty ,Neutrophils ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,Cumulative incidence ,030212 general & internal medicine ,Lymphocyte Count ,Lymphocytes ,Risk factor ,Neutrophil to lymphocyte ratio ,Aged ,business.industry ,Head and neck cancer ,Hazard ratio ,medicine.disease ,Prognosis ,Comorbidity ,Head and neck squamous-cell carcinoma ,Confidence interval ,Head and Neck Neoplasms ,030220 oncology & carcinogenesis ,Geriatrics and Gerontology ,business - Abstract
Neutrophil-to-lymphocyte ratio (NLR), may predict treatment response and outcomes in some human malignancies. However, NLR has rarely been examined in older patients with head and neck squamous cell carcinoma (HNSCC). This study evaluated factors, including pre-treatment evaluation tests, predictive of mortality in older patients with HNSCC.This study prospectively enrolled 233 consecutive HNSCC patients aged 65 years or older. Pre-treatment evaluations included patient demographics, comorbidity, body weight loss, voice handicap index, dysphagia, Beck's depression inventory, comprehensive geriatric assessment, and circulating biomarkers. Cumulative incidence and cause-specific hazard functions were used to analyse the risk factors for overall mortality (OM), cancer mortality (CM), and non-cancer mortality (NCM).Multivariate analyses showed that age, performance scale, NLR, and nodal stage were independent predictors of OM and CM (all P .05). Age, body weight loss, frailty, and NLR were independent predictors of NCM (all P .05). Older age ≥ 75 years and NLR showed strong association with all OM, CM, and NCM (all P .05). NLR2.5 was related to a higher risk of OM (hazard ratio [HR] = 1.77, 95% confidence interval [CI]: 1.05-2.97, P = .031), CM (HR = 1.89, 95% CI: 1.09-3.29, P = .023), and NCM (HR = 6.29, 95% CI: 2.16-18.37, P = .001).Cancer and non-cancer mortalities among older patients with HNSCC may be predicted by several clinical and haematological data. NLR might be used as a circulating prognostic marker for mortality in older patients with HNSCC.
- Published
- 2019
45. Urine-based liquid biopsy: non-invasive and sensitive AR-V7 detection in urinary EVs from patients with prostate cancer
- Author
-
Juhee Park, Vijaya Sunkara, Hong Koo Ha, Ja Yoon Ku, Yoon-Kyoung Cho, Hyun-Kyung Woo, and Chan Ho Lee
- Subjects
Male ,medicine.medical_specialty ,Urinary system ,Biomedical Engineering ,Urology ,Bioengineering ,02 engineering and technology ,Urine ,01 natural sciences ,Biochemistry ,Polymerase Chain Reaction ,law.invention ,Prostate cancer ,Extracellular Vesicles ,law ,Limit of Detection ,Medicine ,Humans ,Digital polymerase chain reaction ,RNA, Messenger ,Liquid biopsy ,Polymerase chain reaction ,business.industry ,010401 analytical chemistry ,Liquid Biopsy ,Reproducibility of Results ,General Chemistry ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,Androgen receptor ,Prostatic Neoplasms, Castration-Resistant ,Receptors, Androgen ,Linear Models ,Biomarker (medicine) ,0210 nano-technology ,business - Abstract
Androgen-receptor splice variant 7 (AR-V7) is associated with castration-resistant prostate cancer (CRPC) and resistance to anti-androgen therapy. Despite its clinical importance, the lack of efficient methods for AR-V7 analysis remains a challenge for broader use of this biomarker in routine clinical practice. Herein, we suggest a practical and non-invasive liquid biopsy method for analysis of AR-V7 in the RNA of urine-derived extracellular vesicles (EVs) without the need for blood withdrawal. Urine-derived EVs were isolated by a lab-on-a-disc integrated with six independent nanofiltration units (Exo-Hexa) allowing simultaneous processing of six individual samples. Rapid enrichment of EVs (
- Published
- 2018
46. Comparison of functional outcomes between laparoscopic radical prostatectomy and robot-assisted laparoscopic radical prostatectomy: a propensity score-matched comparison study
- Author
-
Ja Yoon Ku, Jeong Zoo Lee, Chan Ho Lee, and Hong Koo Ha
- Subjects
medicine.medical_specialty ,Urinary continence ,Laparoscopic radical prostatectomy ,Prostatectomy ,business.industry ,medicine.medical_treatment ,030232 urology & nephrology ,Urology ,Urination disorder ,Urinary incontinence ,General Medicine ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Erectile dysfunction ,Oncology ,030220 oncology & carcinogenesis ,Propensity score matching ,medicine ,lipids (amino acids, peptides, and proteins) ,International Prostate Symptom Score ,medicine.symptom ,business - Abstract
Aim To compare the functional outcomes after laparoscopic radical prostatectomy (LRP) and robot-assisted laparoscopic radical prostatectomy (RARP). Methods Between September 2008 and January 2016, 712 patients underwent radical prostatectomy (RP; 614 LRP and 98 RARP). Recovery of incontinence was evaluated through a 24-h pad test. Urinary and erectile function was evaluated using the International Prostate Symptom Score (IPSS) and the International Index of Erectile Function-5. Follow-up interval was 1, 3, 6 and 12 months after the surgery. The propensity score matching was used to balance the preoperative characteristics. Results The recovery of incontinence was similar to the two groups at 6 and 12 months after the surgery. However, patients underwent RARP restored the continence sooner than those in the LRP group in 1 and 3 months after the surgery (P < 0.001 and 0.001). For the multivariable analysis, the type of RP procedure was a uniquely meaningful contributing factor (P = 0.001, HR = 1.925; 95% CI, 1.299–2.851). In the case of urinary function, the RARP groups showed a better IPSS score than LRP groups at the 1-, 3- and 6-month visits, respectively (P = 0.008, 0.026, 0.001), and the RARP groups early improved compared with LRP groups at the 3-month visit in the case of erectile function (P = 0.018). Conclusion The RARP tended toward getting back the urinary continence earlier than the LRP. In addition, urinary and erectile function recovered more quickly in the RARP group than in the LRP group.
- Published
- 2016
47. Transcript Levels of Androgen Receptor Variant 7 and Ubiquitin-Conjugating Enzyme 2C in Hormone Sensitive Prostate Cancer and Castration-Resistant Prostate Cancer
- Author
-
Ja Yoon Ku, Jeong Zoo Lee, Jung Min Ha, Choung-Soo Kim, Sun Sik Bae, Hong Koo Ha, and Chan Ho Lee
- Subjects
0301 basic medicine ,medicine.medical_specialty ,medicine.drug_class ,Urology ,Biology ,urologic and male genital diseases ,Androgen deprivation therapy ,03 medical and health sciences ,chemistry.chemical_compound ,Prostate cancer ,0302 clinical medicine ,Prostate ,Internal medicine ,Gene expression ,medicine ,Clinical significance ,Androgen ,medicine.disease ,Androgen receptor ,030104 developmental biology ,Castration ,Endocrinology ,medicine.anatomical_structure ,Oncology ,chemistry ,030220 oncology & carcinogenesis ,Cancer research - Abstract
PURPOSE This study is designed to identify the androgen receptor variant 7 (AR-V7) status, clinical significance of AR-V7 in hormone sensitive prostate cancer (HSPC). Then, we evaluated AR-V7 and changes of its target gene, ubiquitin-conjugating enzyme E2C (UBE2C) which is an anaphase-promoting complex/cyclosome (APC/C)-specific ubiquitin-conjugating enzyme, in castration-resistant prostate cancer (CRPC) in serial tumor biopsies from patients receiving androgen deprivation therapy. METHODS We used RT-PCR and Q-PCR assay to evaluate AR-V7, androgen receptor full length (AR-FL), and UBE2C in tumor biopsies from patients with HSPC and CRPC. We examined associations between mRNA expression of AR-V7 and clinicopathologic factors. Furthermore, to identify other potential genes involved in the development of CRPC, RNA sequencing was conducted, using paired prostate cancer (PCa) tissues obtained immediately prior to treatment and at the time of therapeutic resistance. RESULTS A total of 13 HSPC patients and three CRPC patients were enrolled. Neither a high Gleason score (score of 8 and 9) nor a high risk of PCa (a high risk of locally advanced PCa according to NCCN guidelines) was correlated with mRNA expression of AR-V7 in HSPC (P = 0.153 and P = 0.215). The mRNA expression of AR-FL, but not AR-V7, was significantly associated with the mRNA expression of UBE2C level in HSPC (P = 0.007). However, increased expression of AR-V7, not AR-FL, paralleled increased expression of UBE2C in the CRPC specimens (P = 0.03). AR-V7 expression status before ADT was likely related to shorter CRPC development in patients treating ADT. The result of the RNA-sequencing analysis using serial samples from the same patient before and after castration demonstrated an increased level of the PI3K regulatory subunit 1 (P = 0.018). CONCLUSION Our study revealed the role of UBE2C as a marker of the androgen signaling pathway in PCa. Differential gene expression analysis using serial samples from the same patient before and after castration revealed potential genes and pathways involved in development of CRPC. Further studies are needed to determine whether these genes and pathways are potential therapeutic target for CRPC. Prostate 77:60-71, 2017. © 2016 Wiley Periodicals, Inc.
- Published
- 2016
48. Long-term oncologic outcomes of postoperative adjuvant versus salvage radiotherapy in prostate cancer: Systemic review and meta-analysis of 5-year and 10-year follow-up data
- Author
-
Hong Koo Ha, Chan Ho Lee, and Ja Yoon Ku
- Subjects
Oncology ,Biochemical recurrence ,Male ,medicine.medical_specialty ,Salvage therapy ,Sensitivity and Specificity ,Prostate cancer ,Special Article ,Internal medicine ,medicine ,Humans ,Survival rate ,Salvage Therapy ,business.industry ,Prostatic Neoplasms ,Publication bias ,medicine.disease ,Confidence interval ,Surgery ,Treatment Outcome ,Meta-analysis ,Relative risk ,Radiotherapy, Adjuvant ,Adjuvant radiotherapy ,business ,Publication Bias ,Follow-Up Studies - Abstract
Purpose To evaluate the oncologic outcomes between adjuvant radiotherapy (ART) and salvage radiotherapy (SRT) in patients with locally advanced prostate cancer or with adverse pathologic factors including positive surgical margin and high Gleason score. Materials and Methods We searched the literature published from January 2000 until December 2014 at MEDLINE, PubMed, Web of Science, Embase, ProQuest, and Cochrane Library. To be specific, included were studies comparing ART and SRT settings if they followed up oncologic outcomes more than 5 years. Results Overall, 3 retrospective, nonrandomized, observational studies, 1 matched control analysis, and 3 prospective randomized controlled studies met our inclusion criteria including a total of 2,380 patients (1,192 ART vs. 1,188 SRT). Higher favorable results were found in ART than in SRT was seen in the 5-year and 10-year biochemical recurrence (BCR)-free survival (risk ratio [RR], 0.61 and 0.70; 95% confidence interval [CI], 0.54-0.69 and 0.63-0.76). ART had a significantly higher 5-year progression-free survival rate than that in SRT (RR, 0.64; 95% CI, 0.51-0.80), but this was not the same for the 10-year progression-free survival rate (RR, 0.88; 95% CI, 0.72-1.08). There was no significant difference for the 5-year and 10-year overall survival rates between ART and SRT (RR, 0.80 and 0.94; 95% CI, 0.59-1.07 and 0.80-1.11). Conclusions ART showed favorable results in BCR-free survival during the 5-year follow-up period. However, the 10-year progression-free survival and overall survival did not show any difference between ART and SRT.
- Published
- 2015
49. The effect of continuous androgen deprivation treatment on prostate cancer patients as compared with intermittent androgen deprivation treatment
- Author
-
Ja Yoon Ku, Jeong Zoo Lee, and Hong Koo Ha
- Subjects
Male ,medicine.medical_specialty ,Antineoplastic Agents, Hormonal ,medicine.drug_class ,Urological Oncology ,Urology ,Subgroup analysis ,Castration-resistant prostatic neoplasms ,Therapeutics ,Adenocarcinoma ,Antiandrogen ,urologic and male genital diseases ,Drug Administration Schedule ,Prostate cancer ,Clinical endpoint ,Medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Hazard ratio ,Prostatic Neoplasms ,Retrospective cohort study ,Androgen Antagonists ,Middle Aged ,Androgen ,medicine.disease ,Confidence interval ,Surgery ,Prostatic Neoplasms, Castration-Resistant ,Treatment Outcome ,Lymphatic Metastasis ,Androgens ,Disease Progression ,Original Article ,Neoplasm Grading ,business ,Follow-Up Studies - Abstract
Purpose To investigate the efficacy of androgen deprivation treatment (ADT) between continuous and intermittent ADT. Materials and Methods Between January 2006 and May 2015, 603 patients were selected and divided into continuous ADT (CADT) (n=175) and intermittent ADT (IADT) (n=428) groups. The median follow-up in this study was 48.19 (1.0-114.0) months. The primary end point was time to castration resistant prostate cancer (CRPC). The types of ADT were monotherapy and maximal androgen blockade (i.e., luteinizing hormone-releasing hormone agonist and antiandrogen). Results The characteristics of patients showed no significant differences between the CADT and IADT groups, except for the Gleason score (p
- Published
- 2015
50. Cribriform pattern is highly predictive factor of biochemical recurrence in positive surgical margin patients
- Author
-
I.Y. Jeong, J.Z. Lee, Kyu-Sung Lee, Hong Koo Ha, K.H. Kim, Chan Ho Lee, Ja Yoon Ku, Hyun Jun Park, M.J. Kwon, S.H. Han, Juhyun Park, and Seungmin Baek
- Subjects
Biochemical recurrence ,medicine.medical_specialty ,business.industry ,Urology ,medicine ,Positive Surgical Margin ,business ,Surgery ,Predictive factor ,Cribriform pattern - Published
- 2017
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.