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2. High Individual Heterogeneity of Neutralizing Activities against the Original Strain and Nine Different Variants of SARS-CoV-2

Author

Jaafar, Rita, Boschi, Celine, Aherfi, Sarah, Bancod, Audrey, Bideau, Marion Le, Edouard, Sophie, Colson, Philippe, Chahinian, Henri, Raoult, Didier, Yahi, Nouara, Fantini, Jacques, Scola, Bernard La, Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS - Inserm U1072), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-10-IAHU-0003,Méditerranée Infection,I.H.U. Méditerranée Infection(2010), Debanne, Dominique, and Instituts Hospitalo-Universitaires - I.H.U. Méditerranée Infection - - Méditerranée Infection2010 - ANR-10-IAHU-0003 - IAHU - VALID

Subjects
Adult, Male, Models, Molecular, COVID-19 Vaccines, Adolescent, Genotype, Vaccine Efficacy, Antibodies, Viral, Microbiology, Article, COVID-19 Serological Testing, Cohort Studies, Young Adult, vaccine, Chlorocebus aethiops, [SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Animals, Humans, antibodies, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Vero Cells, Aged, Aged, 80 and over, variants, SARS CoV2, SARS-CoV-2, High SARS CoV2, COVID-19, Middle Aged, Antibodies, Neutralizing, QR1-502, Mutation, Spike Glycoprotein, Coronavirus, Female, France, heterogeneity
Abstract

International audience; Since the beginning of the COVID-19 pandemic, several SARS-CoV-2 variants have sequentially emerged. In France, most cases were due to spike D641G-harbouring viruses that descended initially from the Wuhan strain, then by the variant of B.1.160 lineage we called Marseille-4 since the summer of 2020, which was followed by the Alpha and Beta variants in early 2021, then the Delta variant currently. Methods: We determined the neutralising antibody (nAb) titres in sera from convalescent individuals previously infected by these four major local variants and from vaccine recipients to the original Wuhan strain and nine variants, including two recent circulating Delta isolates. Results: The results show high inter-individual heterogeneity in nAbs, especially according to the variant tested. The major variations among nAbs are based on the genotype responsible for the infection. Patients previously infected with the beta and B.1.160 variants had the lowest nAb titres. We show that this heterogeneity is well explained by spike protein mutants modelling using in silico approaches. The highest titres were observed in individuals vaccinated with the Pfizer/BioNTech COVID-19 vaccine, even against the delta variant. Conclusions: Immunity acquired naturally after infection is highly dependent on the infecting variant, and, unexpectedly, mRNA-based vaccine efficacy was shown to be often better than natural immunity in eliciting neutralising antibodies

Published
2021

4. High individual heterogeneity of neutralizing activities against the original 4 strain and 9 different variants of SARS-CoV-2

Author

Jaafar, Rita, primary, Boschi, Celine, additional, Aherfi, Sarah, additional, Bancod, Audrey, additional, Bideau, Marion Le, additional, Edouard, Sophie, additional, Colson, Philippe, additional, Chahinian, Henri, additional, Raoult, Didier, additional, Yahi, Nouara, additional, Fantini, Jacques, additional, and SCOLA, Bernard LA, additional

Published
2021
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5. Epidemiological and genetic characterization of measles virus circulating strains at Marseille, France during 2017–2019 measles outbreak

Author

Jaafar, Rita, primary, Zandotti, Christine, additional, Grimaldier, Clio, additional, Etoundi, Maëlia, additional, Kadri, Ines, additional, Boschi, Celine, additional, Jardot, Priscilla, additional, Colson, Philippe, additional, Raoult, Didier, additional, La Scola, Bernard, additional, and Aherfi, Sarah, additional

Published
2021
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6. High individual heterogeneity of neutralizing activities against the original strain and 9 different variants of SARS-CoV-2

Author

Jaafar, Rita, primary, Boschi, Celine, additional, Aherfi, Sarah, additional, Bancod, Audrey, additional, Bideau, Marion Le, additional, Edouard, Sophie, additional, Colson, Philippe, additional, Chahinian, Henri, additional, Raoult, Didier, additional, Yahi, Nouara, additional, Fantini, Jacques, additional, and SCOLA, Bernard LA, additional

Published
2021
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9. Correlation Between 3790 Quantitative Polymerase Chain Reaction–Positives Samples and Positive Cell Cultures, Including 1941 Severe Acute Respiratory Syndrome Coronavirus 2 Isolates.

Author

Jaafar, Rita, Aherfi, Sarah, Wurtz, Nathalie, Grimaldier, Clio, Hoang, Thuan Van, Colson, Philippe, Raoult, Didier, and Scola, Bernard La

Subjects
*CELL culture, *COVID-19, *VIRAL load, *PUBLIC health, *DISEASE duration, *POLYMERASE chain reaction, *COVID-19 pandemic
Published
2021
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