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441 results on '"Jackson, Mark W."'

1. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis.

Author

Liao, Yun, Zhao, Junjie, Bulek, Katarzyna, Tang, Fangqiang, Chen, Xing, Cai, Gang, Jia, Shang, Fox, Paul L, Huang, Emina, Pizarro, Theresa T, Kalady, Matthew F, Jackson, Mark W, Bao, Shideng, Sen, Ganes C, Stark, George R, Chang, Christopher J, and Li, Xiaoxia

Subjects
Colon, Animals, Mice, Inbred C57BL, Mice, Knockout, Humans, Mice, Colonic Neoplasms, Colitis, Copper, Membrane Proteins, Interleukin-17, Inhibitor of Apoptosis Proteins, Carcinogenesis
Abstract

Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper uptake via the induction of a metalloreductase, STEAP4. IL-17-induced elevated intracellular copper level leads to the activation of an E3-ligase, XIAP, which potentiates IL-17-induced NFκB activation and suppresses the caspase 3 activity. Importantly, this IL-17-induced STEAP4-dependent cellular copper uptake is critical for colon tumor formation in a murine model of colitis-associated tumorigenesis and STEAP4 expression correlates with IL-17 level and XIAP activation in human colon cancer. In summary, this study reveals a IL-17-STEAP4-XIAP axis through which the inflammatory response induces copper uptake, promoting colon tumorigenesis.

Published
2020

3. The Effect of Impactor Geometry on End-to-End Pecan Cracking.

Author

Jackson, Mark W., Langston, Cody M., Madsen, Leah E., and Davis, R. Benjamin

Subjects
*PECAN, *IMAGE analysis, *SOFTWARE architecture, *DESIGN software, *CASCADE impactors (Meteorological instruments)
Abstract

During the industrial pecan shelling process, kernels are often damaged. To address this problem, a study is conducted to experimentally determine improved impactor geometries for end-to-end pecan cracking. Four impactors of varying internal angles (from 30° to 52.5°, in increments of 7.5°) are tested. After cracking, the pecans are passed through an image analysis software designed to detect and measure cracks in their shells. These measurements help classify each pecan into one of four categories: under crack, standard crack, ideal crack, or over crack. Cracked and ideally cracked pecans are preferred for their processability, so the impactor geometries are then evaluated based on their ability to maximize these crack types across the widest impact energy range. For the four impactors tested, the 30° impactor is found to more consistently produce preferred cracks in a larger energy range relative to the other impactors. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Figure S4 from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Author

Taylor, Sarah E., primary, O'Connor, Caitlin M., primary, Wang, Zhizhi, primary, Shen, Guobo, primary, Song, Haichi, primary, Leonard, Daniel, primary, Sangodkar, Jaya, primary, LaVasseur, Corinne, primary, Avril, Stefanie, primary, Waggoner, Steven, primary, Zanotti, Kristine, primary, Armstrong, Amy J., primary, Nagel, Christa, primary, Resnick, Kimberly, primary, Singh, Sareena, primary, Jackson, Mark W., primary, Xu, Wenqing, primary, Haider, Shozeb, primary, DiFeo, Analisa, primary, and Narla, Goutham, primary

Published
2023
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30. Supplementary Figure Legends and Methods from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Author

Taylor, Sarah E., primary, O'Connor, Caitlin M., primary, Wang, Zhizhi, primary, Shen, Guobo, primary, Song, Haichi, primary, Leonard, Daniel, primary, Sangodkar, Jaya, primary, LaVasseur, Corinne, primary, Avril, Stefanie, primary, Waggoner, Steven, primary, Zanotti, Kristine, primary, Armstrong, Amy J., primary, Nagel, Christa, primary, Resnick, Kimberly, primary, Singh, Sareena, primary, Jackson, Mark W., primary, Xu, Wenqing, primary, Haider, Shozeb, primary, DiFeo, Analisa, primary, and Narla, Goutham, primary

Published
2023
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31. Data from The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis

Author

Taylor, Sarah E., primary, O'Connor, Caitlin M., primary, Wang, Zhizhi, primary, Shen, Guobo, primary, Song, Haichi, primary, Leonard, Daniel, primary, Sangodkar, Jaya, primary, LaVasseur, Corinne, primary, Avril, Stefanie, primary, Waggoner, Steven, primary, Zanotti, Kristine, primary, Armstrong, Amy J., primary, Nagel, Christa, primary, Resnick, Kimberly, primary, Singh, Sareena, primary, Jackson, Mark W., primary, Xu, Wenqing, primary, Haider, Shozeb, primary, DiFeo, Analisa, primary, and Narla, Goutham, primary

Published
2023
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47. Students Assessment of a Semidirected Internship Program

Author

Jackson, Richard H. and Jackson, Mark W.

Abstract

Internships can be a valuable experience for geography majors, helping them confirm their choice of an area of emphasis in the discipline, giving them real world experience, and providing contacts that can help them gain full-time employment. This article examines student perception of the relative effectiveness of a semidirected internship program. The program relies on students finding their own internship rather than on programmatic linkages between a department and an employer. Analysis of survey responses of students completing the internship program over a five-year period indicates that students viewed their intern experience very positively, with the least satisfaction related to the level of constructive criticism they received of their work and involvement in discussion of their completed work assignments. (Contains 6 tables and 6 figures.)

Published
2009
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48. Student Contributions to Understanding Conservation and Community on Mount Kilimanjaro

Author

Durrant, Jeffrey O., Durrant, Marie B., and Jackson, Mark W.

Abstract

University students participated in a research project on communities and conservation on Mount Kilimanjaro in Tanzania. Students contributed by gathering data with various methods that will be compiled in a GIS. Living in three villages at different elevations on the mountain, students facilitated GPS mapping, a random survey of over 90 households, and recording of observations and interviews with the people of the villages. While the inclusion of students in the research project brought greater logistical demands, their participation allowed quick collection of data on a broad scale, more intimate knowledge of the three villages and the communities in them, and provided a valuable learning experience for the students with opportunities to develop and carry-out a research project in an international setting.

Published
2004

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