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577 results on '"Jacobsson, Hans"'

1. Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements

Author

Eskian, Mahsa, Alavi, Abass, Khorasanizadeh, MirHojjat, Viglianti, Benjamin L., Jacobsson, Hans, Barwick, Tara D., Meysamie, Alipasha, Yi, Sun K., Iwano, Shingo, Bybel, Bohdan, Caobelli, Federico, Lococo, Filippo, Gea, Joaquim, Sancho-Muñoz, Antonio, Schildt, Jukka, Tatcı, Ebru, Lapa, Constantin, Keramida, Georgia, Peters, Michael, Boktor, Raef R., John, Joemon, Pitman, Alexander G., Mazurek, Tomasz, and Rezaei, Nima

Published
2019
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14. Impact of the first tumor response at eight weeks on overall survival in metastatic breast cancer patients treated with first-line combination chemotherapy

Author

Suzuki, Chikako, Blomqvist, Lennart, Hatschek, Thomas, Carlsson, Lena, Einbeigi, Zakaria, Linderholm, Barbro, Lindh, Birgitta, Loman, Niklas, Malmberg, Martin, Rotstein, Samuel, Söderberg, Martin, Sundqvist, Marie, Walz, Thomas M., Åström, Gunnar, Fujii, Hirofumi, Jacobsson, Hans, and Glimelius, Bengt

Published
2013
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24. Gastroparesis versus dyspepsia by intragastric meal distribution : new diagnostics and definitions ahead

Author

Gryback, Per, Jacobsson, Hans, Neuger, Lucyna, Hellström, Per M., Gryback, Per, Jacobsson, Hans, Neuger, Lucyna, and Hellström, Per M.

Abstract

Gastroparesis often presents a challenge to the practicing gastroenterologist. Postprandial symptoms with nausea and vomiting may not only lead to nutritional and metabolic consequences, but also significant disruption of social activities that often center around food. The treatment options that affect gastric function are limited and often disappointing. The female predominance, the mostly idiopathic and idiosyncratic nature of the illness, often with some common psychiatric co-morbidity, parallels other functional disorders of the gastrointestinal tract. These parallels have provided the rationale for studies investigating alternative diagnostic features of the gastric emptying test as employed in the clinical setting. Hence, not only the regular cut-offs of 60% or 10% gastric retention of a meal at 2 and 4 h, but also a new concept, the intragastric meal distribution at time 0 (IMD0) is now introduced as a plausible diagnostic feature that should be more aligned with the patients' symptoms as they appear in close connection with the meal. Impaired gastric accommodation with absence of fundic relaxation followed by dumping of the meal into antrum is suggested to be diagnostic for functional dyspepsia and gastroparesis. The diagnostic cut-off is considered when more than 57% of the meal is distributed to the distal part of the stomach immediately on food intake. This new diagnostic feature of the gastric emptying profile lend support to better understanding of the patients' symptoms and provides a new basis for pharmacological treatment options in gastroparesis that may provide an improved quality of life in affected individuals.

Published
2020
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25. Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination

Author

Lövgren, Tanja, Wolodarski, Maria, Wickstrom, Stina, Edback, Ulrika, Wallin, Mette, Martell, Eva, Markland, Katrin, Blomberg, Pontus, Nystrom, Maria, Lundqvist, Andreas, Jacobsson, Hans, Ullenhag, Gustav, Ljungman, Per, Hansson, Johan, Masucci, Giuseppe, Tell, Roger, Poschke, Isabel, Adamson, Lars, Mattsson, Jonas, Kiessling, Rolf, Lövgren, Tanja, Wolodarski, Maria, Wickstrom, Stina, Edback, Ulrika, Wallin, Mette, Martell, Eva, Markland, Katrin, Blomberg, Pontus, Nystrom, Maria, Lundqvist, Andreas, Jacobsson, Hans, Ullenhag, Gustav, Ljungman, Per, Hansson, Johan, Masucci, Giuseppe, Tell, Roger, Poschke, Isabel, Adamson, Lars, Mattsson, Jonas, and Kiessling, Rolf

Abstract

Development of T cell-directed immune checkpoint inhibitors (ICI) has revolutionized metastatic melanoma (MM) therapy, but <50% of treated patients experience durable responses. This phase I trial (NCT01946373) investigates the safety/feasibility of tumor-infiltrating lymphocyte (TIL) adoptive cell therapy (ACT) combined with dendritic cell (DC) vaccination in MM patients progressing on ICI. An initial cohort (5 patients) received TIL therapy alone to evaluate safety and allow for optimization of TIL expansion protocols. A second cohort (first-in-man, 5 patients) received TIL combined with autologous tumor lysate-loaded DC vaccination. All patients received cyclophosphamide/fludarabine preconditioning prior to, and intravenous (i.v.) IL-2 after, TIL transfer. The DC vaccine was given as five intradermal injections after TIL and IL-2 administration. [F-18]-FDG PET/CT radiology was performed to evaluate clinical response, according to RECIST 1.1 (on the CT part). Immunological monitoring was performed by flow cytometry and T-cell receptor (TCR) sequencing. In the safety/optimization cohort, all patients had a mixed response or stable disease, but none durable. In the combination cohort, two patients experienced complete responses (CR) that are still ongoing (>36 and >18 months, respectively). In addition, two patients had partial responses (PR), one still ongoing (>42 months) with only a small bone-lesion remaining, and one of short duration (<4 months). One patient died early during treatment and did not receive DC. Long-lasting persistency of the injected TILs was demonstrated in blood. In summary, we report clinical responses by TIL therapy combined with DC vaccination in 4 out of 4 treated MM patients who previously failed ICI.

Published
2020
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40. Complete and long-lasting clinical responses in immune checkpoint inhibitor-resistant, metastasized melanoma treated with adoptive T cell transfer combined with DC vaccination

Author

Lövgren, Tanja, primary, Wolodarski, Maria, additional, Wickström, Stina, additional, Edbäck, Ulrika, additional, Wallin, Mette, additional, Martell, Eva, additional, Markland, Katrin, additional, Blomberg, Pontus, additional, Nyström, Maria, additional, Lundqvist, Andreas, additional, Jacobsson, Hans, additional, Ullenhag, Gustav, additional, Ljungman, Per, additional, Hansson, Johan, additional, Masucci, Giuseppe, additional, Tell, Roger, additional, Poschke, Isabel, additional, Adamson, Lars, additional, Mattsson, Jonas, additional, and Kiessling, Rolf, additional

Published
2020
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45. Effect of blood glucose level on standardized uptake value (SUV) in F-18- FDG PET-scan : a systematic review and meta-analysis of 20,807 individual SUV measurements

Author

Eskian, Mahsa, Alavi, Abass, Khorasanizadeh, MirHojjat, Viglianti, Benjamin L., Jacobsson, Hans, Barwick, Tara D., Meysamie, Alipasha, Yi, Sun K., Iwano, Shingo, Bybel, Bohdan, Caobelli, Federico, Lococo, Filippo, Gea, Joaquim, Sancho-Munoz, Antonio, Schildt, Jukka, Tatci, Ebru, Lapa, Constantin, Keramida, Georgia, Peters, Michael, Boktor, Raef R., John, Joemon, Pitman, Alexander G., Mazurek, Tomasz, Rezaei, Nima, Department of Diagnostics and Therapeutics, Clinicum, and HUS Medical Imaging Center

Subjects
EXPRESSION, TRANSPORTER, PET scan, Blood glucose level, METABOLISM, 3126 Surgery, anesthesiology, intensive care, radiology, INSULIN, SUV, DIABETIC-PATIENTS, 18F-FDG, Diabetes mellitus, POSITRON-EMISSION-TOMOGRAPHY, LUNG-CANCER, HYPERGLYCEMIA, PET quantification, BRAIN-BARRIER, SQUAMOUS-CELL CARCINOMA
Abstract

Objectives To evaluate the effect of pre-scan blood glucose levels (BGL) on standardized uptake value (SUV) in F-18-FDG-PET scan. Methods A literature review was performed in the MEDLINE, Embase, and Cochrane library databases. Multivariate regression analysis was performed on individual datum to investigate the correlation of BGL with SUVmax and SUVmean adjusting for sex, age, body mass index (BMI), diabetes mellitus diagnosis, F-18-FDG injected dose, and time interval. The ANOVA test was done to evaluate differences in SUVmax or SUVmean among five different BGL groups (200 mg/dl). Results Individual data for a total of 20,807 SUVmax and SUVmean measurements from 29 studies with 8380 patients was included in the analysis. Increased BGL is significantly correlated with decreased SUVmax and SUVmean in brain (p

Published
2019

48. Automatic detection of hypoperfused areas in SPECT brain scans

Author

Thurfjell, L., Andersson, J., Pagani, M., Jonsson, C., Hult, R., Lundqvist, R., Wagner, A., Jacobsson, Hans, and Larsson, Stig

Subjects
SPECT imaging -- Analysis, Perfusion (Physiology) -- Diagnosis, Medical imaging equipment -- Analysis, Brain -- Magnetic resonance imaging, Business, Electronics, Electronics and electrical industries
Abstract

We describe a method for automatic identification of areas with perfusion changes in SPECT brain images. An intersubject registration technique is used to stereotactically register images from a selected control group allowing for reference images to be created by averaging the subjects image data. An individual SPECT brain scan can be brought into registration with the reference image and comparison to the normal reference group can be made by subtracting the two volumes. Furthermore, since the variance in the reference group is known, a z-score image or an image coded in standard deviations, can be computed. The SPECT reference volume is defined in the same coordinate system as a brain atlas, and anatomical labeling of areas of interest is possible. We show results from the creation of an average image based on 11 individuals and from its comparison with pathological cases.

Published
1998

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