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467 results on '"Jacobsson, Lennart T H"'

10. One‐Year Treatment Outcomes of Secukinumab Versus Tumor Necrosis Factor Inhibitors in Spondyloarthritis: Results From Five Nordic Biologic Registries Including More Than 10,000 Treatment Courses

Author

Glintborg, Bente, Lindström, Ulf, Giuseppe, Daniela Di, Provan, Sella Aarrestad, Gudbjornsson, Bjorn, Hetland, Merete Lund, Michelsen, Brigitte, Wallman, Johan K., Aaltonen, Kalle, Hokkanen, Anna‐Mari, Nordström, Dan, Jørgensen, Tanja Schjødt, Hansen, Rebekka Lund, Geirsson, Arni Jon, Grøn, Kathrine Lederballe, Krogh, Niels Steen, Askling, Johan, Kristensen, Lars Erik, and Jacobsson, Lennart T. H.

Published
2022
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17. Autoantibodies to Disease‐Related Proteins in Joints as Novel Biomarkers for the Diagnosis of Rheumatoid Arthritis

Author

Lönnblom, Erik, primary, Leu Agelii, Monica, additional, Sareila, Outi, additional, Cheng, Lei, additional, Xu, Bingze, additional, Viljanen, Johan, additional, Hafström, Ingiäld, additional, Andersson, Maria L. E., additional, Bergström, Göran, additional, Hultgård Ekwall, Anna‐Karin, additional, Rudin, Anna, additional, Kastbom, Alf, additional, Sjöwall, Christopher, additional, Jacobsson, Lennart T. H., additional, Kihlberg, Jan, additional, Gjertsson, Inger, additional, and Holmdahl, Rikard, additional

Published
2023
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22. Additional file 3 of Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain—a 5-year follow-up study

Author

Eberhard, Anna, Rydell, Emil, Forslind, Kristina, Bergman, Stefan, Mandl, Thomas, Olofsson, Tor, Jacobsson, Lennart T. H., and Turesson, Carl

Abstract

Additional file 3. Relation for clinical and radiographic parameters with VAS pain; multivariate linear regression. Sensitivity analysis, including inclusion calendar year as covariate.

Published
2023
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24. Additional file 5 of Radiographic damage in early rheumatoid arthritis is associated with increased disability but not with pain—a 5-year follow-up study

Author

Eberhard, Anna, Rydell, Emil, Forslind, Kristina, Bergman, Stefan, Mandl, Thomas, Olofsson, Tor, Jacobsson, Lennart T. H., and Turesson, Carl

Abstract

Additional file 5. Relation for clinical and radiographic parameters with HAQ; multivariate linear regression. Sensitivity analysis, including inclusion calendar year as covariate.

Published
2023
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33. Analyses of plasma inflammatory proteins reveal biomarkers predictive of subsequent development of giant cell arteritis: a prospective study.

Author

Wadström, Karin, Jacobsson, Lennart T H, Mohammad, Aladdin J, Warrington, Kenneth J, Matteson, Eric L, Jakobsson, Magnus E, and Turesson, Carl

Subjects
*GIANT cell arteritis diagnosis, *BIOMARKERS, *BLOOD proteins, *IMMUNOGLOBULINS, *CONFIDENCE intervals, *INFLAMMATION, *BLOOD plasma, *GIANT cell arteritis, *CELL physiology, *RISK assessment, *PROTEOMICS, *INTERFERONS, *RESEARCH funding, *DESCRIPTIVE statistics, *PREDICTION models, *ODDS ratio, *CHEMOKINES, *T cells, *LONGITUDINAL method, *DISEASE risk factors, *DISEASE complications
Abstract

Objective To investigate the relation between biomarkers of inflammation and subsequent development of GCA. Method Participants in the population-based Malmö Diet Cancer Study (MDCS; N  = 30 447), established 1991–96, who were subsequently diagnosed with GCA, were identified in a structured process. GCA-free controls, matched for sex, year of birth and year of screening were selected from the study cohort. Baseline plasma samples were analysed using the antibody-based OLINK proteomics inflammation panel (92 inflammatory proteins). Analyses were pre-designated as hypothesis-driven or hypothesis-generating. In the latter, principal component analysis was used to identify groups of proteins that explain the variance in the proteome. Within components selected based on eigenvalues, proteins with a factor loading of >0.50 were investigated. Results Ninety-four cases with a confirmed incident diagnosis of GCA (median 11.9 years after inclusion) were identified. Among biomarkers with a priori hypotheses, IFN-γ was positively associated with GCA [odds ratio (OR) per s. d. 1.52; 95% CI 1.00, 2.30]. Eight biomarkers in the hypothesis-generating analyses were significantly associated with development of GCA. Among these, higher levels of IFN-γ (OR 2.37; 95% CI 1.14, 4.92) and monocyte chemotactic protein 3 (MCP3) (OR 4.27; 95% CI 1.26, 14.53) were particularly associated with increased risk of GCA in the subset sampled <8.5 years before diagnosis. Several other proteins known to be important for T cell function were also associated with GCA in these analyses, e.g. CXCL9, IL-2, CD40 and CCL25. Conclusion Elevated IFN-γ levels were found years prior to diagnosis of GCA. T cell activation may precede the clinical onset of GCA. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Incident Gout and Risk of First‐Time Acute Coronary Syndrome: A Prospective, Population‐Based Cohort Study in Sweden.

Author

Drivelegka, Panagiota, Jacobsson, Lennart T. H., Lindström, Ulf, Bengtsson, Karin, and Dehlin, Mats

Subjects
ACUTE coronary syndrome, GOUT, CORONARY disease, COHORT analysis, SECONDARY care (Medicine)
Abstract

Objective: To investigate the risk of first‐time acute coronary syndrome (ACS) in a large cohort of primary and secondary care patients with incident gout compared to the general population. Methods: Using register data for the period 2007–2017, we conducted a prospective, population‐based cohort with 20,146 patients with incident gout (mean age 65.6 years; 67.4% male) and 83,517 matched population controls without prior history of coronary heart disease. We calculated incidence rates (IRs) and hazard ratios (HRs) adjusted for baseline comorbidities and dispensed prescriptions. In a sensitivity analysis, we included gout cases and controls with no previously diagnosed comorbidity (6,075 cases and 44,091 controls). Results: The IR of first‐time ACS was significantly increased in the gout cohort compared to controls (9.1 versus 6.3 of 1,000 person‐years). Unadjusted Cox regression showed that gout patients had higher risk of first‐time ACS compared to controls (HR 1.44 [95% confidence interval (95% CI) 1.33–1.56]), with a higher HR in women (HR 1.64 [95% CI 1.41–1.90]) than in men (HR 1.36 [95% CI, 1.24–1.50]). In multivariable analysis, the risk diminished but remained significant (HR 1.15 [95% CI 1.06–1.25]). The risk was similar in the sensitivity analysis (HR 1.20 [95% CI 1.01–1.44]) and still higher in women (HR 1.34 [95% CI 0.86–2.08]) than in men (HR 1.18 [95% CI 0.97–1.44]). Conclusion: Patients with incident gout have a 44% increased risk of first‐time ACS, higher in women than in men. This risk is largely explained by the underlying comorbidities, but there is still a modestly increased risk that may be due to gout‐related factors. [ABSTRACT FROM AUTHOR]

Published
2023
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41. Cancer risk in patients with spondyloarthritis treated with TNF inhibitors: a collaborative study from the ARTIS and DANBIO registers

Author

Hellgren, Karin, Dreyer, Lene, Arkema, Elizabeth V, Glintborg, Bente, Jacobsson, Lennart T H, Kristensen, Lars-Erik, Feltelius, Nils, Hetland, Merete Lund, Askling, Johan, Baecklund, Eva, Kastbom, Alf, Turesson, Carl, Lindqvist, Elisabeth, Jacobsson, Lennart T.H, Klareskog, Lars, dʼElia, Helena Forsblad, Rantapää-Dahlqvist, Solbritt, and van Vollenhoven, Ronald

Published
2017
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44. Incident Gout and Risk of First‐TimeAcute Coronary Syndrome: A Prospective, Population‐BasedCohort Study in Sweden

Author

Drivelegka, Panagiota, Jacobsson, Lennart T. H., Lindström, Ulf, Bengtsson, Karin, and Dehlin, Mats

Abstract

To investigate the risk of first‐time acute coronary syndrome (ACS) in a large cohort of primary and secondary care patients with incident gout compared to the general population. Using register data for the period 2007–2017, we conducted a prospective, population‐based cohort with 20,146 patients with incident gout (mean age 65.6 years; 67.4% male) and 83,517 matched population controls without prior history of coronary heart disease. We calculated incidence rates (IRs) and hazard ratios (HRs) adjusted for baseline comorbidities and dispensed prescriptions. In a sensitivity analysis, we included gout cases and controls with no previously diagnosed comorbidity (6,075 cases and 44,091 controls). The IR of first‐time ACS was significantly increased in the gout cohort compared to controls (9.1 versus 6.3 of 1,000 person‐years). Unadjusted Cox regression showed that gout patients had higher risk of first‐time ACS compared to controls (HR 1.44 [95% confidence interval (95% CI) 1.33–1.56]), with a higher HR in women (HR 1.64 [95% CI 1.41–1.90]) than in men (HR 1.36 [95% CI, 1.24–1.50]). In multivariable analysis, the risk diminished but remained significant (HR 1.15 [95% CI 1.06–1.25]). The risk was similar in the sensitivity analysis (HR 1.20 [95% CI 1.01–1.44]) and still higher in women (HR 1.34 [95% CI 0.86–2.08]) than in men (HR 1.18 [95% CI 0.97–1.44]). Patients with incident gout have a 44% increased risk of first‐time ACS, higher in women than in men. This risk is largely explained by the underlying comorbidities, but there is still a modestly increased risk that may be due to gout‐related factors.

Published
2023
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