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1. Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Author

Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, and Bernd Wollscheid

Subjects
Science
Abstract

Cell surface proteins contribute to neuronal development and activity-dependent synaptic plasticity. Here, the authors perform a time-resolved surfaceome analysis of developing primary neurons and in response to homeostatic synaptic scaling and chemical long-term potentiation (cLTP), revealing surface proteome remodeling largely independent of global proteostasis.

Published
2020
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2. Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Author

Marc van Oostrum, Benjamin Campbell, Charlotte Seng, Maik Müller, Susanne tom Dieck, Jacqueline Hammer, Patrick G. A. Pedrioli, Csaba Földy, Shiva K. Tyagarajan, and Bernd Wollscheid

Subjects
Science
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2020
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3. Author Correction: Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Author

Benjamin Campbell, Patrick G. A. Pedrioli, Shiva K. Tyagarajan, Marc van Oostrum, Charlotte Seng, Bernd Wollscheid, Csaba Földy, Maik Müller, Jacqueline Hammer, Susanne tom Dieck, University of Zurich, and Wollscheid, Bernd

Subjects
Science, Long-Term Potentiation, General Physics and Astronomy, 10050 Institute of Pharmacology and Toxicology, 610 Medicine & health, 1600 General Chemistry, Synaptic plasticity, General Biochemistry, Genetics and Molecular Biology, Protein protein interaction network, 1300 General Biochemistry, Genetics and Molecular Biology, Animals, Homeostasis, Protein Interaction Maps, Author Correction, lcsh:Science, Cells, Cultured, Neurons, Neuronal Plasticity, Multidisciplinary, Mass spectrometry, Chemistry, Cell Membrane, Dynamics (mechanics), Excitatory Postsynaptic Potentials, Membrane Proteins, General Chemistry, 3100 General Physics and Astronomy, Protein-protein interaction networks, Rats, Protein Transport, Proteostasis, Synapses, Neuronal development, 570 Life sciences, biology, lcsh:Q, Neuroscience
Abstract

Neurons are highly compartmentalized cells with tightly controlled subcellular protein organization. While brain transcriptome, connectome and global proteome maps are being generated, system-wide analysis of temporal protein dynamics at the subcellular level are currently lacking. Here, we perform a temporally-resolved surfaceome analysis of primary neuron cultures and reveal dynamic surface protein clusters that reflect the functional requirements during distinct stages of neuronal development. Direct comparison of surface and total protein pools during development and homeostatic synaptic scaling demonstrates system-wide proteostasis-independent remodeling of the neuronal surface, illustrating widespread regulation on the level of surface trafficking. Finally, quantitative analysis of the neuronal surface during chemical long-term potentiation (cLTP) reveals fast externalization of diverse classes of surface proteins beyond the AMPA receptor, providing avenues to investigate the requirement of exocytosis for LTP. Our resource (neurosurfaceome.ethz.ch) highlights the importance of subcellular resolution for systems-level understanding of cellular processes.

Published
2020

4. Surfaceome dynamics reveal proteostasis-independent reorganization of neuronal surface proteins during development and synaptic plasticity

Author

Shiva K. Tyagarajan, Bernd Wollscheid, Charlotte Seng, Csaba Földy, Patrick G. A. Pedrioli, Susanne tom Dieck, Marc van Oostrum, Maik Müller, Jacqueline Hammer, Benjamin Campbell, University of Zurich, and Wollscheid, Bernd

Subjects
0301 basic medicine, Science, General Physics and Astronomy, 610 Medicine & health, 1600 General Chemistry, Genetics and Molecular Biology, AMPA receptor, Biology, Article, Synaptic plasticity, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, 1300 General Biochemistry, Genetics and Molecular Biology, lcsh:Science, Multidisciplinary, Synaptic scaling, 10242 Brain Research Institute, Mass spectrometry, Long-term potentiation, General Chemistry, 3100 General Physics and Astronomy, Protein-protein interaction networks, Transport protein, 030104 developmental biology, Proteostasis, General Biochemistry, Proteome, Connectome, 570 Life sciences, biology, Neuronal development, lcsh:Q, Neuroscience, 030217 neurology & neurosurgery
Abstract

Neurons are highly compartmentalized cells with tightly controlled subcellular protein organization. While brain transcriptome, connectome and global proteome maps are being generated, system-wide analysis of temporal protein dynamics at the subcellular level are currently lacking. Here, we perform a temporally-resolved surfaceome analysis of primary neuron cultures and reveal dynamic surface protein clusters that reflect the functional requirements during distinct stages of neuronal development. Direct comparison of surface and total protein pools during development and homeostatic synaptic scaling demonstrates system-wide proteostasis-independent remodeling of the neuronal surface, illustrating widespread regulation on the level of surface trafficking. Finally, quantitative analysis of the neuronal surface during chemical long-term potentiation (cLTP) reveals fast externalization of diverse classes of surface proteins beyond the AMPA receptor, providing avenues to investigate the requirement of exocytosis for LTP. Our resource (neurosurfaceome.ethz.ch) highlights the importance of subcellular resolution for systems-level understanding of cellular processes., Nature Communications, 11 (1), ISSN:2041-1723

Published
2020
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