1. The beneficial effect of a diet with low glycaemic index on 24 h glucose profiles in healthy young people as assessed by continuous glucose monitoring
- Author
-
Anne Dornhorst, Audrey E. Brynes, Jacqui Adamson, and Gary Frost
- Subjects
Adult ,Blood Glucose ,Male ,medicine.medical_specialty ,Medicine (miscellaneous) ,Fasting glucose ,Internal medicine ,Area under curve ,Dietary Carbohydrates ,Humans ,Medicine ,Monitoring, Physiologic ,Nutrition and Dietetics ,Continuous glucose monitoring ,business.industry ,Healthy subjects ,Reproducibility of Results ,Fasting ,Diet ,Glycemic index ,Endocrinology ,Postprandial ,Glycemic Index ,Area Under Curve ,Healthy individuals ,Low glycaemic index ,Female ,business - Abstract
Elevated postprandial glycaemia has been linked to CVD in a number of different epidemiological studies involving predominantly non-diabetic volunteers. The MiniMed continuous glucose monitor, which measures blood glucose every 5 min, over a 24 h period, was used to investigate changes in blood glucose readings before and after instigating a diet with low glycaemic index (GI) for 1 week in free-living healthy individuals. Nine healthy people (age 27 (sem 1·3) years, BMI 23·7 (sem 0·7) kg/m2, one male, eight females) completed the study. A reduction in GI (59·7 (sem 2) v. 52·1 (sem 2), Pv. 4·4 (sem 0·3) mmol/l, Pv. 5·1 (sem 0·2) mmol/l, P=0·004), area under the 24 h glucose curve (8102 (sem 243) v. 750 (sem 235) mmol/l per min, P=0·004) and area under the overnight, 8 h glucose curve (2677 (sem 92) v. 2223 (sem 121) mmol/l per min, P=0·01). The present study provides important data on how a simple adjustment to the diet can improve glucose profiles that, if sustained in the long term, would be predicted from epidemiological studies to have a favourable influence on CVD.
- Published
- 2005
- Full Text
- View/download PDF