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225 results on '"Jacquier, Hervé"'

1. Evaluation of the contribution of shotgun metagenomics in the microbiological diagnosis of liver abscesses

Author

Kimseng, Hadrien, Rossi, Geoffrey, Danjean, Maxime, Jimenez-Araya, Bryan, Chaligne, Camille, Galy, Adrien, Souhail, Bérénice, Bert, Frédéric, Leflon, Véronique, Fihman, Vincent, Caillault, Amandine, Demontant, Vanessa, Seng, Sarah, Trawinski, Elisabeth, N.’Debi, Melissa, Boizeau, Laure, Jacquier, Hervé, Ronot, Maxime, Reizine, Edouard, Le Roy, Vincent, Lefort, Agnès, Rodriguez, Christophe, Lepeule, Raphaël, and Woerther, Paul-Louis

Published
2023
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3. Capnocytophaga zoonotic infections: a 10-year retrospective study (the French CANCAN study)

Author

Beauruelle, Clémence, Plouzeau, Chloé, Grillon, Antoine, Isnard, Christophe, Corvec, Stéphane, Degand, Nicolas, Jacquier, Hervé, Amara, Marlène, Mizrahi, Assaf, Diedrich, Tristan, Piau, Caroline, Farfour, Eric, Bonzon, Lucas, Le Brun, Cécile, Walewski, Violaine, Bille, Emmanuelle, Dortet, Laurent, Guillard, Thomas, Soismier, Nathalie, Le Guen, Ronan, Morand, Philippe, de Ponfilly, Gauthier Péan, Le Monnier, Alban, and Héry-Arnaud, Geneviève

Published
2022
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5. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Alviset, Sophie, Armand-Lefèvre, Laurence, Baldeyrou, Marion, Becker, Agathe, Boibieux, André, Bonacorsi, Stéphane, Burucoa, Christophe, Cambau, Emmanuelle, Casalegno, Jean-Sébastien, Cointe, Aurélie, Cremniter, Julie, Destras, Grégory, Duquaire, Paul, Geslain, Guillaume, Gustave, Claude-Alexandre, Jacquier, Hervé, Kouatchet, Achille, Lecorche, Emmanuel, Lejeune, Manon, Lina, Bruno, Mahieu, Rafaël, Maamar, Adel, Michaud, Anthony, Monnard, Céline, Montravers, Philippe, Neuwirth, Catherine, Péan de Ponfilly, Gauthier, Pichon, Maxime, Plouzeau, Chloé, Poyart, Claire, Quenot, Jean-Pierre, Rzepecki, Vincent, Stéphan, Robin, Timsit, Jean-François, Tran-Dinh, Alexy, Vandenesch, François, Vigier, Emmanuelle, Gastli, Nabil, Loubinoux, Julien, Daragon, Matthieu, Lavigne, Jean-Philippe, Saint-Sardos, Pierre, Pailhoriès, Hélène, Lemarié, Carole, Benmansour, Hanaa, d’Humières, Camille, Broutin, Lauranne, Dauwalder, Olivier, Levy, Michael, Auger, Gabriel, Kernéis, Solen, and Cattoir, Vincent

Published
2021
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8. Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1

Author

Figliuzzi, Matteo, Jacquier, Hervé, Schug, Alexander, Tenaillon, Olivier, and Weigt, Martin

Subjects
Quantitative Biology - Quantitative Methods, Condensed Matter - Statistical Mechanics, Quantitative Biology - Biomolecules
Abstract

The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, e.g., of central importance for our understanding of the phenotypic effect of mutations related to disease and antibiotic drug resistance. Here we develop a novel inference scheme for mutational landscapes, which is based on the statistical analysis of large alignments of homologs of the protein of interest. Our method is able to capture epistatic couplings between residues, and therefore to assess the dependence of mutational effects on the sequence context where they appear. Compared to recent large-scale mutagenesis data of the beta-lactamase TEM-1, a protein providing resistance against beta-lactam antibiotics, our method leads to an increase of about 40% in explicative power as compared to approaches neglecting epistasis. We find that the informative sequence context extends to residues at native distances of about 20{\AA} from the mutated site, reaching thus far beyond residues in direct physical contact., Comment: 14 pages, 5 figures. Supplementary files on the publisher's website: http://mbe.oxfordjournals.org/content/early/2015/10/06/molbev.msv211.short?rss=1

Published
2015
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9. New Insights Into the Therapeutic Management of Varicella Zoster Virus Meningitis: A Series of 123 Polymerase Chain Reaction–Confirmed Cases.

Author

Dulin, Marie, Chevret, Sylvie, Salmona, Maud, Jacquier, Hervé, Bercot, Béatrice, Molina, Jean-Michel, Lebeaux, David, and Munier, Anne-Lise

Subjects
AKAIKE information criterion, VARICELLA-zoster virus, INTRAVENOUS therapy, POLYMERASE chain reaction, CEREBROSPINAL fluid
Abstract

Background Varicella zoster virus (VZV) can reactivate and cause meningitis, but few studies have distinguished it from meningoencephalitis regarding treatment recommendations. The objective of this study was to assess the outcomes of a large series of patients with VZV meningitis according to their therapeutic management. Methods We conducted a bicentric retrospective cohort study, in Paris, France, including all adult patients with a cerebrospinal fluid sample positive for VZV by polymerase chain reaction between April 2014 and June 2022. We distinguished meningitis from encephalitis according to the International Encephalitis Consortium criteria. Unfavorable outcome was defined as mortality or functional sequelae defined by a loss of 2 points on the modified Rankin Scale. Results We included 123 patients with meningitis. Among them, 14% received no antivirals, while 20% were treated with oral valacyclovir alone, 41% with a short course of intravenous (IV) acyclovir before switch to valacyclovir, and 25% with a long course of IV acyclovir. Outcomes were favorable regardless of antiviral regimen. In multivariate analysis, only age, underlying immunosuppression, and cranial radiculitis appear to be predictive factors for longer IV therapy, based on the Akaike information criterion. Conclusions In this study, patients with VZV meningitis had a good outcome, with no evidence of any impact of the treatment strategy. However, further studies are needed to support the possibility of milder treatment in immunocompetent patients, avoiding cost and side effects of IV acyclovir. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

Author

Manquat Elsa, Le Dorze Matthieu, Pean De Ponfilly Gauthier, Benmansour Hanaa, Amarsy Rishma, Cambau Emmanuelle, Soyer Benjamin, Chousterman Benjamin Glenn, and Jacquier Hervé

Subjects
Enterobacterales, Extended-spectrum β-lactamase (ESBL-E), High-level expressed AmpC cephalosporinase-producing Enterobacterales (HLAC-E), Third-generation cephalosporin-resistant Enterobacterales (3GCR-E), Intestinal carriage, Respiratory sample, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background Empirical antimicrobial therapy (EAT) is a challenge for community-acquired, hospital-acquired and ventilator-associated pneumonia, particularly in the context of the increasing occurrence of third-generation cephalosporin-resistant Enterobacterales (3GCR-E), including extended-spectrum beta-lactamase Enterobacterales (ESBL-E) and high-level expressed AmpC cephalosporinase-producing Enterobacterales (HLAC-E). To prevent the overuse of broad-spectrum antimicrobial therapies, such as carbapenems, we assessed the performance of screening for intestinal carriage of HLAC-E in addition to ESBL-E to predict 3GCR-E (ESBL-E and/or HLAC-E) presence or absence in respiratory samples in ICU, and to evaluate its potential impact on carbapenem prescription. Materials and methods This monocentric retrospective observational study was performed in a surgical ICU during a 4-year period (January 2013–December 2016). Patients were included if they had a positive culture on a respiratory sample and a previous intestinal carriage screening performed by rectal swabbing within 21 days. Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values and likelihood ratios were calculated for the screening for intestinal carriage of ESBL-E, HLAC-E and 3GCR-E (ESBL-E and/or HLAC-E) as predictor of their absence/presence in respiratory samples. Impact of HLAC-E and ESBL-E reporting on EAT was also studied. Results 765 respiratory samples, retrieved from 468 patients, were analyzed. ESBL-E prevalence was 23.8% in rectal swab and 4.4% in respiratory samples. HLAC-E prevalence was 9.0% in rectal swabs and 3.7% in respiratory samples. Overall, the 3GCR-E prevalence was 31.8% in rectal swabs and 7.7% in respiratory samples. NPVs were 98.8%, 98.0% and 96.6% for ESBL-E, HLAC-E and 3GCR-E, respectively. Over the study period, empirical antimicrobial therapy was initiated for 315 episodes of respiratory infections: 228/315 (72.4%) were associated with negative intestinal carriage screening for both HLAC-E and ESBL-E, of whom 28/228 (12.3%) were treated with carbapenems. Of 23/315 (7.3%) cases with screening for positive intestinal carriage with HLAC-E alone, 10/23 (43.5%) were treated with carbapenems. Conclusion Systematic screening and reporting of HLAC-E in addition to ESBL-E in intestinal carriage screening could help to predict the absence of 3GCR-E in respiratory samples of severe surgical ICU patients. This could improve the appropriateness of EAT in ICU patients with HAP and may prevent the overuse of carbapenems.

Published
2020
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17. Clinical features and prognostic factors of listeriosis: the MONALISA national prospective cohort study

Author

Hausfater, Pierre, Pourriat, Jean-Louis, Casalino, Enrique, Riou, Bruno, Pateron, Dominique, Yéni, Patrick, Bricaire, François, Ville, Yves, Azria, Elie, Dommergues, Marc, Bergmann, Jean-François, Wolff, Michel, Mira, Jean-Paul, Guillevin, Loïc, Zuber, Mathieu, Abasse, Soumeth, Aberrane, Saïd, Abgueguen, Pierre, Abokasem, Ayman, Abraham, Bruno, Ache-Papillon, Chantal, Adam, Pascal, Adam, Marie-Noëlle, Adhoute, Xavier, Adoue, Daniel, Afi, Moncef, Afroukh, Nawel, Agha-Mir, Ilhem, Aissa, Nejla, Aissaoui, Liamine, Akerman, Grégory, Akkari, Ali, Al Chaar, Majed, Al Freijat, Faraj, Al-Jalaby, Bachar, Albert, Didier, Albertini, Marie-Thérèse, Albinet, Hélène, Alfonsi, Gwenaël, Ali, Youssef, Chaouche, Zahr-Eddine Ali, Allart, Anne, Alric, Laurent, Améri, Alain, Amoura, Zahir, Ampère, Alexandre, Amroun, Hakim, Ananivi, Amévi, Ancelin, Pascal, André, Thierry, Andremont, Antoine, Andreotti, Dominique, Andriamaneo, Hélinoro, Andriau, Clara, Anglaret, Hélène, Anguel, Nadia, Annaix, Véronique, Anteur, Wassila, Anuset, Delphine, Aoudia, Ourida, Arabi, Miloud, Archambaud, Muriel, Archambaud, Maryse, Ardiet, Emmanuel, Argaud, Laurent, Arista, Sophie, Arlet, Guillaume, Armengaud, Jean, Arnal, Jean-Michel, Arnault, Isabelle, Arsène, Olivier, Assaf, Ziad, Assi, Assi, Assouline, David, Astruc, Dominique, Aubard, Yves, Aubert, Claude, Aubry, Jean-Paul, Auburtin, Marc, Aucher, Philippe, Audeguy, Philippe, Audié, Jean-Pierre, Aumaitre, Hugues, Aumersier, Michel, Auroux, Jean, Autret, Fanny, Auvray, Etienne, Ayach, Badih, Aye, Paul, Ayouz, Khélifa, Bachelier, Marie-Nadège, Badia, Thomas Bachelot Philippe, Badila, Patrice, Bador, Julien, Badurescu, Viorica, Baldesi, Olivier, Bandaly, Françoise, Bandin, Olivia, Bani-Sadr, Firouzé, Bannier, Stéphanie, Baranger, Thierry, Barazer, Isabelle, Barbier, Marie-Christine, Barbier, François, Barbier, Carole, Barbieux, Marianne, Marie, Barboteau, Annick, Barbut, Patricia, Baret, Mylène, Barière, François, Baril, Jean-Yves, Barillot, Isabelle, Barjon, Geneviève, Barnaud, Guilène, Barraduc, Régine, Barraud, Francis, Barraud, Olivier, Barre, Eric, Barrelet, Audrey, Barrier, Jocelyn, Bart, Fréderic, Barthélémy, Gérard, Baty, Gaëlle, Baud, Olivier, Baudel, Jean-Luc, Bay, Jacques-Olivier, Bay, Jérôme, Bazin, Claude, Beague, Sébastien, Beal Ardisson, Dominique, Beaune, Bertrand, Beauplet-Lepage, Anne, Bébéar, Cécile, Bechade, Dominique, Becherrawy, Céline, Becker-Schneider, Michelle, Bednarek, Nathalie, Bedock, Bernard, Begon, Edouard, Bekguesmia, Zaineb, Belaisch-Amart, Joëlle, Belhadj, Karim, Belle, Evelyne, Belmonte, Olivier, Belot, Jean-Pierre, Bemrah, Abdelkader, Ben Soltana, Mouna, Benbara, Amélie, Benddif-Fin, Faiza, Bénézit, François, Benifla, Jean-Louis, Benjelloul, Amine, Benkaci, Yacine, Benkhelil, Abdelaziz, Benoit-Cattin, Thierry, Benoit-Coustou, Sophie, Bensadoun, René-Jean, Bensaid, Thierry, Jacques Bensaude, Raoul, Bérard, Henri, Bercot, Béatrice, Berdin, Bruno, Berger, Marc, Berger, Pierre, Bergheul, Smail, Bergues, Benoît, Berland, Yvon, Bernard, Claude, Bernard, Louis, Bernardaud, Bérangère, Bernardi, Franck, Bernardin, Gilles, Bernasconi, François, Bert-Marcaz, Patrick, Berteaux, Béatrice, Berth-Farges, Anne, Berthelot, Gilles, Berthet, Jean, Bertrand, Kevin, Bertrou, Anne, Besnard, Marianne, Bessede, Emilie, Bethery, Philippe, Beuscart, Claude, Beyne-Rauzy, Odile, Beytout, Jean, Bezian, Marie-Christine, Bicais, Brigitte, Bidart, Sabine, Bidault, Christian, Biessy, Hélène, Bigot, Pierre, Bildea, Adrianna, Bille, Emmanuelle, Billy, Christophe, Biron, Nathalie, Bizet, Jérôme, Blaise, Didier, Blaise, Agathe, Blaison, Gilles, Blaka, Mariam, Blanc, Pierre, Blanc, Stéphane, Blanc-Amrane, Véronique, Blanchard, Pierre, Blanchard-Marche, Geneviève, Blancs, Michèle, Blazejewski, Caroline, Bléher, Yves, Blewoussi, Koffi, Blondet, Romain, Blot, François, Blum, Georges-Fabrice, Bodson, Lucien, Boidin, Emilie, Boileau, Julien, Boileau, Pascal, Boin-Gay, Véronique, Boisseau, Martial, Boisselier, Christine, Bollaert, Pierre-Edouard, Bolot, Pascal, Bonacorsi, Stéphane, Bonfils, Marie, Bonitchi, Pascal, Bonnan, Mickael, Bonnefoy, Philippe, Bonnet, Delphine, Bonnet, Richard, Bonnin, Emmanuelle, Bor, Jacques, Borie, Marie-Françoise, Borstein, Bernard, Bossi, Philippe, Botreau, Yves, Bottero, Julie, Bouasria, Abderrezak, Bouaziz, Radia, Bouchaud, Olivier, Bouche, Flore, Bouchet, Gérard, Bouden, Vincent, Boudhane, Amar, Boudy, Carole-Anne, Boue, François, Bouet, Cédric, Claude Boufetteau, Jean, Bouffandeau, Bernard, Bouhour, Damien, Bouiller, Marc, Bouillet, Laurence, Bouissou, Antoine, Boulain, Luc, Bourgeois, Stéphane, Bourgerette, Evelyne, Bourlet, Anne, Bourlière, Marc, Bourrée, Thomas, Bourrouillou, Aude, Boussekey, Nicolas, Boussier, Remi, Boutoille, David, Bouyer, Jean-Luc, Bouyssou-Destriau, Denise, Bouziges, Nicole, Boyer, Michelle, Braem, Louis, Branger, Bernard, Branger, Catherine, Brasme, Lucien, Bray, Philippe, Brazille, Patricia, Bresson, Violaine, Bret, Laurent, Breton, Anne-Laure, Breuil, Jacques, Brevet, Françoise, Briaud, Michel, Bridoux, Delphine, Briend, Delphine, Briere, Anne-Isabelle, de la Hosseraye, Claire Briere, Brieu, Nathalie, Brieux, Jean-Philippe, Brihier, Hélène, Brisou, Patrick, Brival, Marie-Laure, Broche, David, Brochen, Joëlle, Bron, Camille, Bronet, Nathalie, Bronner, Jacques, Bronowicki, Jean-Pierre, Brosset, François, Brottier-Mancini, Elisabeth, Brovedani, Sophie, Bruley des Varannes, Stanislas, Brunel, Pascale, Brunet, Patrick, Brunet, Xavier, Brunet, Stéphanie, Brung-Lefebvre, Maud, Brunot, Vincent, Brusset, Alain, Burc-Struxiano, Laurence, Burdin, Michèle, Bureau, Thierry, Buron, Fanny, Burucoa, Christophe, Cabalion, Jean, Cabasson, Severine, Cabié, André, Cacheux, Victoria, Cadiergue, Vincent, Cadiot, Guillaume, Caille, Vincent, Cailleaux Pierre-Etienne Cailleux, Vincent, Caillon, Jocelyne, Caillot, Denis, Camara, Mohamed, Cambau, Emmanuelle, Cambonie, Gilles, Camiade, Sabine, Canis, Frederique, Canitrot, Meriem, Canu, Nathalie, Capellier, Gilles, Carbillon, Lionel, Carbonelle, Bernard, Carbonelle, Etienne, Carboni, Marion, Carbonne, Bruno, Carcenac, Francis, Cardot, Florence, Carette, Sylvie, Cariou, Sylvie, Carli, Pierre, Carmagnol, Françoise, Caroli-Bosc, François-Xavier, Caron, François, Cartron, Guillaume, Casali, Patrick, Casanovas, Olivier, Cassignard, Dominique, Castaing, Denis, Castel, Brisse, Castelin, Sandrine, Castelnau, Pierre, Cathebras, Pascal, Catineau, Jean, Catteu, Sylviane, Cattier, Blandine, Cattoen, Christian, Cattoir, Vincent, Caumes, Eric, Caussin, Jean, Cavalié, François, Ceppa, Franck, Cerf, Charles, Ceriez, Anne, Cervantes, Nathalie, Chabanon-Pouget, Bruno, Chabrol, Amélie, Chachaty, Elisabeth, Chahtour, Hanen, Chaix, Fabrice, Challier, Marion, Chalvon-Demersay, Arnaud, Chambreuil, Guy, Chaminade, Bruno, Chamouine, Abdourahim, Chandesris Joséphine Chapalain-Cagnon, Christine, Chapelle, Alain, Chaplain, Chantal, Chapuzet, Claire, Charachon, Sylvie, Charasse, Christophe, Charbonnier, Thierry, Charlier, Franck, Chassin, Olivier, Chassy, Véronique, Chatellier, Delphine, Chatron, Marlène, Chaussade, Hélène, Chavanet, Pascal, Chavel, Pascale, Chekroun, Ali, Chelle, Wladimir, Chelly, Jonathan, Cherlet, Christel, Chevailler, Alain, Chevalet, Pascal, Chevalier, Yannick, Chidiac, Christian, Chimot, Loïc, Chiouk, Nabil, Chiron, Philippe, Chirouze, Catherine, Chopin, Marie-Charlotte, Choukroun, Gabriel, Chouraqui, Martine, Chraibi, Kamilla, Chudersky, Dominique, Chuzeville, Michel, Cingotti, Michel, Cinquetti, Gael, Ciocan, Dragos, Citony, Isabelle, Claise, Catherine, Clarissou-Philippe, Juliette, Claude, Benoît, Clave, Danielle, Clément, Christophe, Climas, Marie-Thérèse, Coetmeur, Daniel, Cognet, Stéphanie, Cohen, Daniel, Coignard, Sophie, Coindre, Jean-Philippe, Coint, Raphaël, Colamarino, Renato, Colingorski, Anne-Marie, Collard, Olivier, Collet, Michel, Collignon, Anne, Collus, Marie-José, Colombani, Jean-Claude, Colombat, Philippe, Combe, Christian, Condominas, Philippe, Conroy, Marie-Chrsitine, Constans, Thierry, Constantin, Nicole, Contamin, Claudine, Corberand, Damien, Cordier, Anne-Marie, Cordonnier, Charlotte, Corneloup, Hélène, Costa, Yannick, Costa, Frédérique, Coste, Mathieu, Costes, Corinne, Cotes, Françoise, Cotteret, Rabea, Couderc, Louis-Jean, Cougoul, Pierre, Coulaud, Jean-Michel, Coulhon, Marie-Pierre, Coulon, Patrice, Courcol, René, Courillon, Florence, Courjon, Johan, Courouble, Jérémie, Courouge-Dorcier, Dominique, Courtade, Henri, Courtois, Stéphanie, Couturier, Pascal, Créange, Alain, Cremet, Lise, Cremniter, Julie, Croize, Jacques, Crombe, Valérie, Croquet, Ingrid, Cua, Eric, Cufi, Marie-Noelle, Cuvillier, Patrice, Dabysing, Marie-Françoise, Dadoun, Karim, Dagada, Corinne, Dahan, Sonia, Dahoumane, Redouane, Daleas, Jacques, Dallay, Dominique, Dalle, Benoît, Damage, Alexandre, Damaj, Lena, Damaj Gandhi, Laurent, Danalaché, Ana, Danin, Pierre-Eric, Danjean, Marie-Pierre, Danquechin Dorval, Etienne, Dao, Anne, Daoud, Patrick, Darchen, Olivier, Dargère, Sylvie, Darre, Bincy, Dassant, Damien, Dassieu, Gilles, Dattin-Dorrière, Valérie, Daupin, Cedric, Daurel, Claire, Dausset, Jean-Claude, Daval Cote, Mélanie, David, Gary, Davido, Benjamin, De Barbeyrac, Bertille, De Biasi, Michel, De Boysson, Hubert, De Clareuil, Edith, De Kermadec, Jean-Michel, De Martino, Sylvie, De Tayrac, Renaud, De Varax, Roland, De Witte, Sten, Debernardi, Anne, Deboutin, Jean-Luc, Debouverie, Marc, Decoene, Christophe, Decoster, Anne, Decousser, Jean-Winoc, Decré, Dominique, Defebvre, Renaud, Degand, Nicolas, Degreff, Jean-Marc, Deiber, Michel, Delaby, Hélène, Delacour, Thierry, Delahaye, Arnaud, Delarbre, Jean-Marie, Delasalle, Chantal, Delbrouck, Claire, Delecalle, Jean-Gilles, Delesalle, Sophie, Delesalle, Chantal, Delhoustal, Laurence, Deligne, Delphine, Delisle Mizon, Françoise, Delobel, Pierre, Delour, Pierre, Delpeuch, Bruno, Demachy, Marie-Claude, Demarchi, Martin, Demarcq, Marie-Joelle, Demontclos, Henri, Dengo, Jean-Christophe, Deprecq, Sophie, Dequin, Pierre-François, Dereeper, Olivier, Deroux, Alban, Derragui, Aicha, Desblache, Julien, Desbois-Nogard, Nicole, Descamps, Dominique, Descamps, Jean-Michel, Deschamps, Christophe, Deschamps, Jacques, Desemerie, Franck, Desfrere, Luc, Desliers, Joelle, Desnoulez, Laurence, Desplaces, Nicole, Després, Nicolas, Dessin, Jean-François, Destors, Marie, Detante, Olivier, Detave, Mathieu, Detourmignies, Laurence, Devaud, Edouard, Devaux, Yves, Devaux, Bruno, Devianne, François, Devidas, Alain, Devos, Philippe, Dewitte, Camille, Dewulf, Gisèle, Dhennain, Chantal, Di Meglio, Chloé, Diallo, Habiboulaye, Diamantis, Sylvain, Dib, Baihas, Didier, Jean-Marc, Dillies, Anne-Françoise, Dingremont, Claire, Djafari, Noureddine, Djeffal, Abdelmajid, Djerad, Hama, Dollon, Christophe, Doloy, Alexandra, Domart, Yves, Donay, Jean-Luc, Dopeux, Loïc, Dorr, Gaelle, Doucet Populaire, Florence, Dournon, Nathalie, Dreyfus, Michel, Dreyfuss, Didier, Du Cheyron, Damien, Dubois, Elodie, Dubois, Nicolas, Dubosc-Marchenay, Nadine, Dubourdieu, Béatrice, Dubroca, Nadine, Dubus, Jean-Christophe, Duche, Catherine, Duchene, Francis, Dudeffant, Patrick, Duez, Jean-Marie, Duhaut, Pierre, Duluc, Françoise, Dumouchel, Hélène, Dumoulard, Bruno, Dupin, Clarisse, Dupon, Michel, Dupont, Mathieu, Dupont, Damien, Dupont, Patrick, Dupre-Narlet, Emmanuelle, Dupretz, Peggy, Dupuy, Claire-Antoinette, Durand, Michel, Durand, Annie, Durliat-Ellie, Solène, Durox, Hélène, Dussopt, Christine, Dutasta, Fabien, Duval, Véronique, Dzeing, Ella, Eboue, Florence, Ede, Cyrille, Eid, Hanna, El Yamani, Abderrazak, Elbez, Annie, Eldeghedy, Mohamed, Elena-Daumas, Martine, Elhadad, Simon, Elharie-Heraux, Zoubida, Eloy, Clarence, Emeriau, Marie-Etiennette, Emond, Jean-Philippe, Equy, Véronique, Erena-Penet, Anne-Sophie, Esnault, Cecilia, Esposito, Laure, Essouri, Sandrine, Estépa, Laurence, Estève, Vincent, Etchemendy, Sabine, Ettahar, Nicolas, Eustache, Marie-Line, Evillard, Mathieu, Evreux, Françoise, Eychene, Jean-Marc, Eyer, Didier, Eymerit, Philippe, Fabre, Jean-Luc, Fabre, Claire, Faibis, Frédéric, Falchero, Lionel, Falguières, Odile, Fallouh, Hassan, Fanjaud, Nicolas, Fantin, Bruno, Farah, Ibrahim, Farto-Bensasson, Fernanda, Fauchais, Anne-Laure, Fauchart, Jean-Pierre, Faucher, Anna, Faucheux, Jean-Marc, Faudon-Gibelin, Anne, Faurie, Pierre, Fèbre, Claudine, Feddal, Toufik, Ferhat Carre, Assia, Ferreira-Maident, Nicole, Ferreyra, Milagros, Ferroni, Agnès, Ferry, Tristan, Feugier, Pierre, Feugier, Jean-Claude, Fezoui, Hacene, Fiette, Hélène, Fille, Alexandra, Filloux, Jean-Michel, Fily, Fabien, Fines, Marguerite, Fissore Magdelein, Cristel, Flahault, Mathilde, Floriot, Christian, Foguem, Clovis, Fonsale, Nathalie, Fontenel, Benoît, Forest, Anne-Marie, Forest, Anne, Forestier, Emmanuel, Fortin, Louise, Fortineau, Nicolas, Fos, Marie-Pierre, Foucart, Saskia, Fouilhoux, Alain-Charles, Fournel, Pierre, Fournier, Damien, Fourrier, François, Fraisse, Thibaut, Fredenucci, Isabelle, Fremin-Batteux, Odile, Frey, Janine, Frimat, Luc, Froidure, Marie, Fruchart, Christophe, Fruleux, Nathalie, Fuhrmann, Christine, Fuillet, Michel, Funakoshi, Nathalie, Fur, Alain, Gabez-Therou, Patricia, Gaborieau, Valerie, Gabriel-Soléan, Sylvie, Gachassin, Laurence, Gaide, Jean-François, Gaillard, Julia, Gaillard, Jean-Louis, Gaillart, Tiphaine, Gaizi, Sad, Gallo, Nicolas, Gameiro, Manuel-Luis, Garandeau, Caroline, Garbi, Aurelie, Garcera, Yves, Gardes, Ghislaine, Garesslin, Olivier, Garnier, Fabien, Garofano, Marie, Garosi, Olivier, Garre, Michel, Garrec, Hélène, Garrigues, Bernard, Gaschet, Anne, Gascon, Alexandre, Gascou, Emmanuel, Gasnault, Jacques, Gatfosse, Marc, Gattault, Jean-François, Gatti, Hélène, Gauche, Bernard, Gaudard, Philippe, Gaudelus, Joel, Gaudry, Stéphane, Gauduchon, Valérie, Gaulthier, Jean-Baptiste, Gauthier, Yvan, Gebeile, Rémi, Geffray, Loïc, Geffroy, Françoise, Geissler, Alain, Gelez, Maud, Gendrin, Vincent, Gengembre, Guy, Gentilhomme, Hervé, Gérart Pons, Sandrine, Germain, Marie-Claude, Gesquière, Julien, Ghedira, Adel, Ghevaert, Christine, Gillot, Jean-Michel, Girard, Edouard, Girard, Serge, Girard, Pierre-Marie, Girard-Buttaz, Isabelle, Giraud, Martine, Glorieux, Isabelle, Goburdhun, Chandrah, Godin, Michel, Godon, Catherine, Goehringer, François, Goffart, Sylvie, Goidin, Isabelle, Goldgran Toledano, Daniele, Golfier, François, Goll, Armand, Gontieron, Olivier, Goquelin, Anne, Got, Laurence, Goudeau, Alain, Goujard, Cécile, Goupil, François, Gouraud, François, Gourlaouen, Alain, Gournay, Jérôme, Goustille, Julien, Goux, Alain, Grandclerc, Benoît, Grange, Jean-Didier, Granger, Thierry, Granier, Françoise, Granier, Michèle, Grasset, Denis, Gravet, Alain, Grawey, Isabelle, Greder Belan, Alix, Grelaud, Jean-Jacques, Grenet, Karine, Gressier, Bernard, Grignon, Bernadette, Grimprel, Emmanuel, Grise, Geneviève, Grobost, Vincent, Gross Goupil, Marine, Grossi, Olivier, Gruffat, Brigitte, Gruson, Anne, Guénard, Yves, Guérard, Arnaud, Guérin, Bruno, Guérin, Mathilde, Guérin, Claude, Guerquin, Bernard, Guerrot, Dominique, Guéry, Benoît, Gueudet, Philippe, Gueugniaud, Pierre-Yves, Guichard, Isabelle, Guichart, François, Guiden, Ozel, Guider, Bertrand, Guillarmé Grossmann, Pascale, Guillemot, François, Guillet, Pierre, Guillet-Caruba, Christelle, Guillois, Bernard, Guilloy, Olivier, Guimard, Thomas, Guimard, Karine, Guimier, Philippe, Guinard, Jérôme, Guinet, François, Guisset, Olivier, Guitteaud, Karine, Gutmann, Laurent, Guyetand, Severine, Haccourt, Fabian, Hacot, Jean-Pierre, Hadou, Tahar, Haiat, Stéphanie, Haioun, Corinne, Hajjar, Mostapha, Hamitou, Zakaria, Hammami, Sarah, Hamon-Charles, Sophie, Hamou-Plotkine, Laurence, Hanouz, Jean-Luc, Harbi, Samia, Harlé, Jean-Robert, Haro, Sophie, Harou, Christian, Harvey, Thierry, Hatem, Ghada, Hausermann, Marie-Hélène, Hauss, Pierre-Alexandre, Hayoun, Fabrice, Hecham, Moussa, Heches, Xavier, Hedjem, Nourredine, Heidt, Anne, Heisel, Nicolas, Heluwaert, Fréderic, 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Jardel, Henry, Jarlier, Vincent, Jarrige, Luc, Jarrousse, Bernard, Jauhlac, Benoît, Jault, Véronique, Jault, Thierry, Jaunait, Eric, Javouhey, Etienne, Jean, Rodolphe, Jean, Julie, Jean-Pierre, Hélène, Jeanmaire, Eliette, Jeannot, Katy, Jeddi, Hassen, Jego, Mickael, Jennane, Selim, Join-Lambert, Olivier, Joly, Pascal, Jonquet, Olivier, Josien, Eric, Jouatte, Fabienne, Jouffret, Agnès, Jourde-Chiche, Noémie, Jourdes, Emilie, Jouvencel, Philippe, Jouzel, Charlotte, Julienne, Geneviève, Jullian, Eric, Juven, Agnès, Juvin, Philippe, Kaidomar, Michel, Kaiser, Thomas, Kalfon, Pierre, Kaltenbach, Georges, Kamar, Nassim, Kansau, Imad, Kara, Ali, Karaoui, Leila, Karirisi, Apollinaire, Karkous, Bernard, Kassis, Marie, Kayal, Samer, Keller, Marie, Kemenar, Chrystelle, Kennouche, Samir, Kerchache, Aissa, Kerleau, Jean-Marc, Kervegant, Anne-Gaelle, Khalifa-Thellier, Sandrine, Radhouane-Khanjari, Fethi, Kherouf, Hakim, Khodeir, Nordine, Kibbrecht, Eric, Kim, An, Kisterman, Jean-Paul, Kittschke, Bernard, Klapczynski, Frédéric, Kodzin, Marie-José, Konate, Bano, Kouaho, Sylvain, Koulmann, Laurence, Krechiem, Karim, Kubab, Sarah, Kubiak, Charles, Kurtz, Jean-Emmanuel, Labadie, Philippe, Labarrière, Damien, Labaune-Kiss, Andrea, Labé, Aurélie, Labourdette, Isabelle, Labrousse, Philippe, Labussière, Anne-Sophie, Lachenal, Florence, Lacroix, Jérôme, Lafeuillade, Alain, Lafforgue, Marie-Odile, Lafon, Ingrid, Lagasse, Jean-Pierre, Lagrandeur, Julien, Lalot, Jean-Marc, Lalu, Mélissa, Laluque, Simone, Lamache, Sébastien, Lamarca, Richard, Lamberet, Aurore, Lambert, Thierry, Lambiotte, Fabien, Lamia, Bouchra, Lamoine-Gimet, Ghislaine, Lamour, Armelle, Lamy, Brigitte, Lanba, Patrice, Landgraf, Nathalie, Landraud, Luc, Laporte, Jean-Patrick, Larible, Claire, Larrazet, Fabrice, Larroche, Claire, Lasbasses, Claudine, Lassel, Ludovic, Lassere, Bertrand, Laudat, Patrice, Lauque, Dominique, Laurens, Etienne, Laurent, Frédéric, Lauretta, Raphael, Laurin, Max, Lauzanne, Brigitte, Lavalard, Emmanuelle, Lavenu, Isabelle, Lavigne, Jean-Philippe, Le Baron, François, Le Berre, Rozenn, Le Berruyer, Pierre-Yves, Le Bideau, Marc, Le Boterff, Cécile, Le Chevallier, Sylvain, Le Coustumier, Alain, Le Du, Anne, Le Goff, Valérie, Le Henaff, Catherine, Le Lay, Geneviève, Le Maout, Gilles, Le Pierres, Athéna, Le Pimpec, Patricia, Le Poulain, Marguerite, Le Reste, Anne-Marie, Le Sec, Ludovic, Le Turdu, Françoise, Leautez-Nainville, Sophie, Lebas, Eddy, Leblond, Véronique, Lebreton, Marie-Annick, Lebreton, Didier, Lecaillon-Thibon, Evelyne, Lechat, Sylvie, Lechiche, Catherine, Lecis, Alain, Leclercq, Roland, Lecomte, Claire, Lécuyer, Hervé, Ledru, Sylvie, Leduc, Dominique, Leflon, Véronique, Lefort, Christine, Lefranc, Hélène, Lefrant, Jean-Yves, Legendre, Christophe, Legoff, Isabelle, Legout, Laurence, Legrand, Mathieu, Legras, Annick, Legros, Antoine, Leguen, Virginie, Leibinger, Franck, Lelièvre, Jean-Daniel, Lellouche, Franck, Lemaignen, Adrien, Lemarie, Romain, Lemble, Chantal, Lemenand, Olivier, Lemercier, Fanny, Lemery, Didier, Lemmens, Bruno, Lemyze, Malcolm, Leneveu, Michel, Léonetti, Françoise, Léonnet, Caroline, Léotard, Sophie, Lepeletier, Didier, Lepelletier, Didier, Lepeule, Raphael, Lepiller, Quentin, Lequen, Laurence, Leroux, Lionel, Leroux, Stéphane, Leroy, Hélène, Leroy, Vincent, Leroy, Olivier, Lesage, Fabrice, Lescat, Mathilde, Lesecq, Ludovic, Lessene, Aude, Lessinger, Jean-Marc, Letellier, Claire, Letellier, Nicolas, Letouzey, Vincent, Letranchant, Lorraine, Levast, Marion, Leveneur, Yann, Levent, Thierry, Levy, Marie, Levy, Marc, Leysenne, David, Libeau, Benoît, Likose, Ebutu, Lima, Suzanne, Lina, Gérard, Lioger, Bertrand, Lionnet, Benoît, Lipovac, Anne-Sophie, Loffeier, Vincent, Loison, Françoise, Lorchleac'h, Aurélien, Lorge, Fabienne, Loriferne, Jean-François, Lorléa'ch, Aurélien, Louart, Guillaume, Loury-Lariviere, Isabelle, Loustaud, Véronique, Lozniewski, Alain, Luciani, Roger-Charles, Luminitan Elena Lupean, Luca, Lureau, Pierre, Lutz-Murphy, Marie-France, Mbimba, Luwawu, M'Bey, Damien, Maakaroun, Abdallah, Macci, Valérie, Magdoud, Fatma, Mager, Guy, Magna, Théophile, Magny, Jean-François, Mahaza, Chetaou, Mahé, Isabelle, Maillard, Christine, Maillet, Jean-Jacques, Maillet, François, Maillez, Sébastien, Maillot, François, Maisonneuve, Antoine, Makdessi, Solène, Malbrunot, Claire, Malbruny, Brigitte, Malderet, Caroline, Malfuson, Jean-Valère, Malherbe, Philippe, Malherbe, Patrick, Malhiere, Sophie, Mandelbrot, Laurent, Mandin, Laurent, Mandjee, Aziza, Manéglier, Benjamin, Mansouria, Mohammed, Marcu, Elena, Mariette, Jean-Bernard, Mariette, Sylvie, Markarian, Jacques, Marmouset, Carole, Marpeau, Olivier, Marret, Olivier, Marsepoil, Thierry, Marterl-Lafay, Isabelle, Martha, Benoît, Marthelet, Patrick, Martin, Xavier, Martin, Florence, Martin, Pierre, Martin, Régine, Martin, Christian, Martin Lefèvre, Laurent, Martineau, Olivier, Martinet, Olivier, Martinez, Valérie, Martinot, Martin, Martres, Pascale, Marty, 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Jean, Mielczarek, Severine, Mignart, Sophie, Mignaut, Virginie, Migraine Bouvagnet, Audrey, Mihout, Fabrice, Mille, Catherine, Millet, Olivier, Milpied, Noel, Mimoz, Olivier, Minet, Jacques, Minguet, Bertrand, Mohty, Mohamad, Moiton, Marie-Pierre, Monarchi, Richard, Monceau, Yannick, Monchi, Mehran, Monlun, Eric, Monsegu, Jacques, Montagne, Nathalie, Montcriol, Ambroise, Montmasson, Bernard, Mootien, Paramasiven, Moquet, Olivier, Morando, Virginie, Moreau, Anne-Sohie, Morel, Yves, Morelon, Emmanuel, Morin-Fatome, Armelle, Morincomme, Mathieu, Morlat, Philippe, Mosser, Laurent, Motard-Picheloup, Annie, Mottaz, Philippe, Moulinoux, Claire, Mouly, Laurence, Mourad, Georges, Mouries, Jean-Claude, Moussa, Hecham, Moustache, Audrey, Muir, Jean-François, Murbach, Valérie, N'guyen, Yohann, N'guyen, Jean-Claude, N'guyen-Khac, Florence, Nabholtz, Jean-Marc, Naceur, Tarik, Nakhleh, Jean, Nare, Aline, Nassif, Xavier, Nathan-Bonnet, Frédérique, Negrery, Huguette, Negrier, Claude, Neri, Dominique, Nesrine, Hakima, Neuwirth, Catherine, Ngami, Eugène, Carole Ngo Bell, Elisabeth, Nicobaharaye, Dieudonné, Nicolet, Laurent, Nicolet, Laurence, Nicolino, Marc, Niel, Philippe, Nikodijevic, Karine, Nkunzimana, Jean-Marie, Noel, Christian, Noirot, Alain, Noto, Philippe, Noulard, Marie-Noelle, Ntalu Nkato, Christophe, Nyunga, Martine, Obiols, Julien, Ochocki, Patrick, Odent, Sylvie, Olivier, Brigitte, Oliviero, Gérard, Ondze, Basile, Orléva, Oléna, Orode, Paul, Osman, Henri, Oswald, Eric, Otean, Paola, Ouazir, Abderkader, Ozanon, Christophe, Paccalin, Marc, Pages, Marie-Christine, Paindaveine, Bénédicte, Pangon, Béatrice, Pannecouck, Jean-Marie, Paquet, Jean-Christophe, Parent, Sabrina, Parisi-Duchene, Elisabeth, Pasche, Jérôme, Pasdeloup, Thierry, Patin, David, Patrigeon, René-Gilles, Patry, Isabelle, Paul, Jean-Gabriel, Pavel, Simona, Pavic, Michel, Pawlotsky, Jean-Michel, Payan, Christopher, Payen, Christiane, Péan, Yves, Péchinot, Frédérique, Péchinot, André, Pecquet, Matthieu, 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Poncelet, Christophe, Pop, Daniela, Porcheron, Martine, Pordes, Réginald, Porthault, Eric, Portneuf, Marc, Pottier, Anne, Pouedras, Pascal, Poulain, Jocelyne, Poulain, Gérard, Poupet, Hélène, Pouyanne, Julien, Pouzoullic, Marie, Poyart, Claire, Pozzetto, Bruno, Prazuck, Thierry, Pressac, Dominique, Prévost, Fabrice, Prince, Sylvie, Priollet, Pascal, Proost, Olivier, Protar, Daniel, Pujade Lauraine, Eric, Pujol, Antoine, Puybasset, Louis, Puyhardy, Jean, Quentin, Vincent, Quinsat, Denis, Rabier, Valérie, Radaoui, Fouzia, Radenac, Florian, Radenne, Sylvie, Raffenot, Didier, Raffi, François, Rahmani, Hassène, Ramanantsoa, Céline, Ranchon, Guillaume, Ranta, Dana, Raoult, Didier, Rasigade, Jean-Philippe, Rassiat, Emmanuel, Raulin, Olivia, Ravaud, Alain, Ravet, Nathalie, Razafimahefa, Hasinrina, Razafimahery, Mirana, Re, Daniel, Real, Philippe, Rebattu, Paul, Rebeyrotte, Catherine, Reboul, Pascal, Reboux, Anne-Hélène, Recule, Christine, Redonnet, Jean-Philippe, Redor, Alexis, Regouby, Yves, 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2017
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21. Evaluation of ceftolozane-tazobactam susceptibility on a French nationwide collection of Enterobacterales

Author

Jousset, Agnès B., primary, Bernabeu, Sandrine, additional, Emeraud, Cécile, additional, Bonnin, Rémy A., additional, Lomont, Alexandra, additional, Zahar, Jean Ralph, additional, Merens, Audrey, additional, Isnard, Christophe, additional, Soismier, Nathalie, additional, Farfour, Eric, additional, Fihman, Vincent, additional, Yin, Nicolas, additional, Barraud, Olivier, additional, Jacquier, Hervé, additional, Ranc, Anne-Gaëlle, additional, Laurent, Frédéric, additional, Corvec, Stéphane, additional, d'Epenoux, Louise Ruffier, additional, Bille, Emmanuelle, additional, Degand, Nicolas, additional, Plouzeau, Chloé, additional, Guillard, Thomas, additional, Cattoir, Vincent, additional, Mizrahi, Asaf, additional, Grillon, Antoine, additional, Janvier, Frédéric, additional, Brun, Cécile Le, additional, Amara, Marlène, additional, Bastide, Mathilda, additional, Lemonnier, Alban, additional, and Dortet, Laurent, additional

Published
2023
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22. Multicenter Evaluation of the FilmArray Blood Culture Identification 2 Panel for Pathogen Detection in Bloodstream Infections

Author

Caméléna, François, primary, Péan de Ponfilly, Gauthier, additional, Pailhoriès, Hélène, additional, Bonzon, Lucas, additional, Alanio, Alexandre, additional, Poncin, Thibaut, additional, Lafaurie, Matthieu, additional, Dépret, François, additional, Cambau, Emmanuel, additional, Godreuil, Sylvain, additional, Chenouard, Rachel, additional, Le Monnier, Alban, additional, Jacquier, Hervé, additional, and Berçot, Béatrice, additional

Published
2023
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23. Detection of SARS-CoV-2 in Saliva and Nasopharyngeal Swabs According to Viral Variants

Author

Salmona, Maud, primary, Chaix, Marie-Laure, additional, Feghoul, Linda, additional, Mahjoub, Nadia, additional, Maylin, Sarah, additional, Schnepf, Nathalie, additional, Jacquier, Hervé, additional, Walle, Eve-Marie, additional, Helary, Marion, additional, Mellon, Guillaume, additional, Osinski, Nathalie, additional, Zebiche, Widad, additional, Achili, Yacine, additional, Amarsy, Rishma, additional, Mahé, Véronique, additional, Le Goff, Jérôme, additional, and Delaugerre, Constance, additional

Published
2022
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24. Respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in severe SARS-CoV-2 pneumonia: a multicenter randomised controlled trial

Author

Fartoukh, Muriel, Nseir, Saad, Mégarbane, Bruno, Cohen, Yves, Lafarge, Antoine, Contou, Damien, Thille, Arnaud, Galerneau, Louis-Marie, Reizine, Florian, Cour, Martin, Klouche, Kada, Navellou, Jean-Christophe, Bitker, Laurent, Rousseau, Alexandra, Tuffet, Sophie, Simon, Tabassome, Voiriot, Guillaume, Elabbadi, Alexandre, Turpin, Matthieu, Verdet, Charlotte, Préau, Sébastien, Wallet, Frédéric, Loiez, Caroline, Voicu, Sebastian, Jacquier, Hervé, Tandjaoui-Lambiotte, Yacine, Jaureguy, Françoise, Alloui, Chakib, Azoulay, Elie, Bercot, Béatrice, Plantefeve, Gaëtan, Claudinon-Courpon, Aurore, Henry, Amandine, Pichon, Maxime, Schwebel, Carole, Tadié, Jean-Marc, Auger, Gabriel, Argaud, Laurent, Chabchoub, Malek, Kolenda, Camille, Vandenesch, François, Godreuil, Sylvain, Piton, Gael, Jeannot, Kay, Danjou, William, CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hypoxie et PhysioPathologie (HP2), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), CHU Pontchaillou [Rennes], Hospices Civils de Lyon (HCL), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and The study was sponsored by Assistance Publique – Hôpitaux de Paris (Délégation à la Recherche Clinique et à l’Innovation), and funded by a grant from the Fondation de l’AP-HP (Project Code: APHP200392/EUDRACT no: 2020-001324-33).

Subjects
Microbiology (medical), Randomised controlled trial, Infectious Diseases, [SDV]Life Sciences [q-bio], Antibiotics use, Intensive care unit, General Medicine, Multiplex PCR, Covid-19
Abstract

International audience; Objectives: We aimed at assessing the efficacy and safety on antibiotics exposure of a strategy combining a respiratory multiplex PCR (mPCR) with enlarged panel and daily procalcitonin (PCT) measurements, as compared with a conventional strategy, in critically ill adult patients with laboratory-confirmed SARS-CoV-2 pneumonia.Methods: This multicentre, parallel-group, open-label, randomised controlled trial enrolled patients admitted to 13 intensive care units (ICU) in France. Patients were assigned (1:1) to the control strategy, where antibiotic streamlining remained at the discretion of the physicians, or interventional strategy, consisting of using mPCR and daily PCT measurements within the first seven days of randomisation to streamline initial antibiotic therapy, with antibiotic continuation encouraged when PCT was > 1 ng/mL and discouraged if < 1 ng/mL or decreased by 80% from baseline. All patients underwent conventional microbiological tests and cultures. The primary end-point was antibiotic-free days at day 28.Results: Between April 20st and November 23st 2020, 194 patients were randomised, of whom 191 were retained in the intention-to-treat analysis. Respiratory bacterial coinfection was detected in 48.4% (45/93) and 21.4% (21/98) in the interventional and control group, respectively. The number of antibiotic-free days was 12.0 (0.0; 25.0) and 14.0 (0.0; 24.0) days, respectively (difference -2.0, (95% CI -10.6 to 6.6), P=0.89). Superinfection rates were high (51.6% and 48.5%, respectively). Mortality rates and ICU lengths of stay did not differ between groups.Conclusion: In severe SARS-CoV-2 pneumonia, the mPCR/PCT algorithm strategy did not affect 28-day antibiotics exposure nor the major clinical outcomes, as compared with routine practice.

Published
2023

27. Faecal carriage of ESBL-producingEscherichia coliin a remote region of Niger

Author

Jacquier, Hervé, primary, Assao, Bachir, additional, Chau, Françoise, additional, Guindo, Ousmane, additional, Condamine, Bénédicte, additional, Magnan, Mélanie, additional, Bridier-Nahmias, Antoine, additional, Sayingoza-Makombe, Nathan, additional, Moumouni, Aissatou, additional, Page, Anne-Laure, additional, Langendorf, Céline, additional, Coldiron, Matthew E, additional, Denamur, Erick, additional, and de Lastours, Victoire, additional

Published
2022
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28. Capturing the mutational landscape of the beta-lactamase TEM-1

Author

Jacquier, Hervé, Birgy, André, Le Nagard, Hervé, Mechulam, Yves, Schmitt, Emmanuelle, Glodt, Jérémy, Bercot, Beatrice, Petit, Emmanuelle, Poulain, Julie, Barnaud, Guilène, Gros, Pierre-Alexis, and Tenaillon, Olivier

Published
2013

29. Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France

Author

Farfour, Eric FE, Dortet, Laurent, Guillard, Thomas, Chatelain, Nicolas, Poisson, Agathe, Mizrahi, Assaf, Fournier, Damien, Bonnin, Rémy, Degand, Nicolas, Morand, Philippe, Janvier, Frédéric, Fihman, Vincent, Corvec, Stephane, Broutin, Lauranne, Le Brun, Cécile, Yin, Nicolas, Héry-Arnaud, Geneviève, Grillon, Antoine, Bille, Emmanuelle, Jean-Pierre, Hélène, Amara, Marlène, Jaureguy, Francoise, Isnard, Christophe, Cattoir, Vincent, Diedrich, Tristan, Flevin, Emilie, Merens, Audrey, Jacquier, Hervé, Vasse, Marc, Farfour, Eric FE, Dortet, Laurent, Guillard, Thomas, Chatelain, Nicolas, Poisson, Agathe, Mizrahi, Assaf, Fournier, Damien, Bonnin, Rémy, Degand, Nicolas, Morand, Philippe, Janvier, Frédéric, Fihman, Vincent, Corvec, Stephane, Broutin, Lauranne, Le Brun, Cécile, Yin, Nicolas, Héry-Arnaud, Geneviève, Grillon, Antoine, Bille, Emmanuelle, Jean-Pierre, Hélène, Amara, Marlène, Jaureguy, Francoise, Isnard, Christophe, Cattoir, Vincent, Diedrich, Tristan, Flevin, Emilie, Merens, Audrey, Jacquier, Hervé, and Vasse, Marc

Abstract

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were E. coli (72.0%), Klebsiella pneumoniae (9.7%), Proteus mirabilis (5.8%), and Enterobacter cloacae complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in P. mirabilis to 19.5% in K. pneumoniae, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of E. coli was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2022

32. Massive Increase, Spread, and Exchange of Extended Spectrum β-Lactamase—Encoding Genes Among Intestinal Enterobacteriaceae in Hospitalized Children With Severe Acute Malnutrition in Niger

Author

Woerther, Paul-Louis, Angebault, Cécile, Jacquier, Hervé, Hugede, Henri-Charles, Janssens, Ann-Carole, Sayadi, Sani, Mniai, Assiya El, Armand-Lefèvre, Laurence, Ruppé, Etienne, Barbier, François, Raskine, Laurent, Page, Anne-Laure, de Rekeneire, Nathalie, and Andremont, Antoine

Published
2011
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33. Emergence and Dissemination of Extended-Spectrum β-Lactamase—Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population

Author

Woerther, Paul-Louis, Angebault, Cécile, Lescat, Mathilde, Ruppé, Etienne, Skurnik, David, Mniai, Assiya El, Clermont, Olivier, Jacquier, Hervé, Costa, Anaelle Da, Renard, Magaly, Bettinger, Régis Marc, Epelboin, Loïc, Dupont, Claire, Guillemot, Didier, Rousset, François, Arlet, Guillaume, Denamur, Erick, Djossou, Félix, and Andremont, Antoine

Published
2010

36. Impact of a 24/7 multiplex-PCR on the management of patients with confirmed viral meningitis

Author

Péan de Ponfilly, Gauthier, primary, Chauvin, Anthony, additional, Salmona, Maud, additional, Benmansour, Hanaa, additional, Bercot, Béatrice, additional, Camelena, Francois, additional, Courbin, Virginie, additional, Eyer, Xavier, additional, Lecorche, Emmanuel, additional, Mougari, Faïza, additional, Munier, Anne-Lise, additional, Revue, Eric, additional, LeGoff, Jérôme, additional, Cambau, Emmanuelle, additional, and Jacquier, Hervé, additional

Published
2021
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37. Origins and breadth of pairwise epistasis in an α-helix of β-lactamase TEM-1

Author

Birgy, André, primary, Roussel, Clément, additional, Kemble, Harry, additional, Mullaert, Jimmy, additional, Panigoni, Karine, additional, Chapron, Audrey, additional, Chatel, Jérémie, additional, Magnan, Mélanie, additional, Jacquier, Hervé, additional, Cocco, Simona, additional, Monasson, Rémi, additional, and Tenaillon, Olivier, additional

Published
2021
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39. Reliability and Safety of Bedside Blind Bone Biopsy Performed by a Diabetologist for the Diagnosis and Treatment of Diabetic Foot Osteomyelitis

Author

Féron, Florine, primary, de Ponfilly, Gauthier Péan, additional, Potier, Louis, additional, Gauthier, Diane-Cécile, additional, Salle, Laurence, additional, Laloi-Michelin, Marie, additional, Munier, Anne-Lise, additional, Jacquier, Hervé, additional, Vidal-Trécan, Tiphaine, additional, Julla, Jean-Baptiste, additional, Carlier, Aurélie, additional, Abouleka, Yawa, additional, Venteclef, Nicolas, additional, Grall, Nathalie, additional, Mercier, Frédéric, additional, Riveline, Jean-Pierre, additional, Senneville, Éric, additional, Gautier, Jean-François, additional, Roussel, Ronan, additional, and Kevorkian, Jean-Philippe, additional

Published
2021
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40. Multicentric evaluation of BioFire FilmArray Pneumonia Panel for rapid bacteriological documentation of pneumonia

Author

Gastli, Nabil, primary, Loubinoux, Julien, additional, Daragon, Matthieu, additional, Lavigne, Jean-Philippe, additional, Saint-Sardos, Pierre, additional, Pailhoriès, Hélène, additional, Lemarié, Carole, additional, Benmansour, Hanaa, additional, d’Humières, Camille, additional, Broutin, Lauranne, additional, Dauwalder, Olivier, additional, Levy, Michael, additional, Auger, Gabriel, additional, Kernéis, Solen, additional, Cattoir, Vincent, additional, Alviset, Sophie, additional, Armand-Lefèvre, Laurence, additional, Baldeyrou, Marion, additional, Becker, Agathe, additional, Boibieux, André, additional, Bonacorsi, Stéphane, additional, Burucoa, Christophe, additional, Cambau, Emmanuelle, additional, Casalegno, Jean-Sébastien, additional, Cointe, Aurélie, additional, Cremniter, Julie, additional, Destras, Grégory, additional, Duquaire, Paul, additional, Geslain, Guillaume, additional, Gustave, Claude-Alexandre, additional, Jacquier, Hervé, additional, Kouatchet, Achille, additional, Lecorche, Emmanuel, additional, Lejeune, Manon, additional, Lina, Bruno, additional, Mahieu, Rafaël, additional, Maamar, Adel, additional, Michaud, Anthony, additional, Monnard, Céline, additional, Montravers, Philippe, additional, Neuwirth, Catherine, additional, Péan de Ponfilly, Gauthier, additional, Pichon, Maxime, additional, Plouzeau, Chloé, additional, Poyart, Claire, additional, Quenot, Jean-Pierre, additional, Rzepecki, Vincent, additional, Stéphan, Robin, additional, Timsit, Jean-François, additional, Tran-Dinh, Alexy, additional, Vandenesch, François, additional, and Vigier, Emmanuelle, additional

Published
2021
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43. Additional file 1 of Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

Author

Manquat, Elsa, Dorze, Matthieu Le, De Ponfilly, Gauthier Pean, Benmansour, Hanaa, Rishma Amarsy, Cambau, Emmanuelle, Soyer, Benjamin, Chousterman, Benjamin Glenn, and Jacquier, Hervé

Subjects
polycyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Additional file 1. Supplementary table 1a. Prevalence of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) in intestinal carriage screening and respiratory samples paired by patients. Supplementary table 1b. Prevalence of Enterobacterales producing AmpC cephalosporinase (HLAC-E) in intestinal respiratory samples paired by patients. Supplementary table 1b. Prevalence of Enterobacterales producing AmpC cephalosporinase (HLAC-E) in intestinal cephalosporins (3GCR-E) in intestinal carriage screening and respiratory samples paired by patients.

Published
2021
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46. Additional file 1 of Impact of systematic screening for AmpC-hyperproducing Enterobacterales intestinal carriage in intensive care unit patients

Author

Elsa, Manquat, Matthieu, Le Dorze, Pean De Ponfilly Gauthier, Benmansour Hanaa, Amarsy Rishma, Cambau Emmanuelle, Soyer Benjamin, Chousterman Benjamin Glenn, and Jacquier Hervé

Subjects
polycyclic compounds, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses
Abstract

Additional file 1. Supplementary table 1a. Prevalence of extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) in intestinal carriage screening and respiratory samples paired by patients. Supplementary table 1b. Prevalence of Enterobacterales producing AmpC cephalosporinase (HLAC-E) in intestinal respiratory samples paired by patients. Supplementary table 1b. Prevalence of Enterobacterales producing AmpC cephalosporinase (HLAC-E) in intestinal cephalosporins (3GCR-E) in intestinal carriage screening and respiratory samples paired by patients.

Published
2020
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47. MRI Features Associated With the Detection of Microbial Pathogens by CT-Guided Biopsy in Septic Spondylodiscitis

Author

Chotard, Emilie, primary, Jacquier, Hervé, additional, Bart, Géraldine, additional, Richette, Pascal, additional, Rioux, Christophe, additional, Joly, Véronique, additional, Goossens, Julia, additional, Palazzo, Elisabeth, additional, Forien, Marine, additional, Jelin, Germain, additional, Yazdanpanah, Yazdan, additional, Dieudé, Philippe, additional, Le Goff, Benoît, additional, and Ottaviani, Sébastien, additional

Published
2020
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49. Impact of a 24/7 Rapid Molecular Assay for Influenza Detection on the Prescription of Oseltamivir

Author

Jacquier, Hervé, primary, Péan de Ponfilly, Gauthier, additional, Chauvin, Anthony, additional, Amarsy, Rishma, additional, Benmansour, Hana, additional, Hoang-Nguyen, Dan-Thanh, additional, Lecorché, Emmanuel, additional, Mesnil, Céline, additional, Mougari, Faiza, additional, Munier, Anne-Lise, additional, Salmona, Maud, additional, Berçot, Béatrice, additional, Le Goff, Jérôme, additional, and Cambau, Emmanuelle, additional

Published
2020
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50. Performance of commercial methods for linezolid susceptibility testing of Enterococcus faecium and Enterococcus faecalis

Author

Dejoies, Loren, primary, Boukthir, Sarrah, additional, Péan de Ponfilly, Gauthier, additional, Le Guen, Ronan, additional, Zouari, Asma, additional, Potrel, Sophie, additional, Collet, Anaïs, additional, Auger, Gabriel, additional, Jacquier, Hervé, additional, Fihman, Vincent, additional, Dortet, Laurent, additional, and Cattoir, Vincent, additional

Published
2020
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