19 results on '"Jah, Hawanatu"'
Search Results
2. Intense and Mild First Epidemic Wave of Coronavirus Disease, The Gambia
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Abatan, Baderinwa, Agboghoroma, Orighomisan, Akemoke, Fatai, Antonio, Martin, Awokola, Babatunde, Bittaye, Mustapha, Bojang, Abdoulie, Bojang, Kalifa, Brotherton, Helen, Cerami, Carla, Clarke, Ed, D'Alessandro, Umberto, de Silva, Thushan, Drammeh, Mariama, Forrest, Karen, Hofmann, Natalie, Jagne, Sherifo, Jah, Hawanatu, Jarju, Sheikh, Jaye, Assan, Jobe, Modou, Kampmann, Beate, Manjang, Buba, Martinez-Alvarez, Melisa, Mohammed, Nuredin, Nadjm, Behzad, Ndiath, Mamadou Ousmane, Nkereuwem, Esin, Nwakanma, Davis, Oko, Francis, Okoh, Emmanuel, Okomo, Uduak, Olatunji, Yekini, Oriero, Eniyou, Prentice, Andrew M., Roberts, Charles, Roca, Anna, Sabally, Babanding, Sambou, Sana, Samateh, Ahmadou, Secka, Ousman, Sesay, Abdul Karim, Singhateh, Yankuba, Susso, Bubacarr, Usuf, Effua, Vilane, Aminata, and Wariri, Oghenebrume
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Epidemics -- Statistics -- Gambia ,Disease transmission -- Statistics ,Health - Abstract
By the end of October 2020, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic had spread to 6 continents and caused >45 million coronavirus disease (COVID-19) cases and 1.1 [...]
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- 2021
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3. Development of a Pediatric Ebola Predictive Score, Sierra Leone
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Fitzgerald, Felicity, Wing, Kevin, Naveed, Asad, Gbessay, Musa, Ross, J.C.G., Checchi, Francesco, Youkee, Daniel, Jalloh, Mohamed Boie, Baion, David E., Mustapha, Ayeshatu, Jah, Hawanatu, Lako, Sandra, Oza, Shefali, Boufkhed, Sabah, Feury, Reynold, Bielicki, Julia, Williamson, Elizabeth, Gibb, Diana M., Klein, Nigel, Sahr, Foday, and Yeung, Shunmay
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Ebola hemorrhagic fever -- Comparative analysis ,Ebola virus -- Comparative analysis ,Conjunctivitis -- Comparative analysis ,Pediatrics -- Comparative analysis ,Virus diseases -- Comparative analysis ,Health ,World Health Organization - Abstract
The Ebola virus disease (EVD) outbreak in West Africa claimed >11,000 lives with nearly 30,000 cases (l). During the outbreak in Sierra Leone, patients arriving at healthcare facilities were screened [...]
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- 2018
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4. Ebola virus disease in children, Sierra Leone, 2014-2015
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Fitzgerald, Felicity, Naveed, Asad, Wing, Kevin, Gbessay, Musa, Ross, J.C.G., Checchi, Francesco, Youkee, Daniel, Jalloh, Mohammed Boie, Baion, David, Mustapha, Ayeshatu, Jah, Hawanatu, Lako, Sandra, Oza, Shefali, Boufkhed, Sabah, Feury, Reynold, Bielicki, Julia A., Gibb, Diana M., Klein, Nigel, Sahr, Foday, and Yeung, Shunmay
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Children -- Diseases ,Ebola virus infections -- Development and progression -- Patient outcomes ,Health - Abstract
The Ebola virus disease (EVD) outbreak in West Africa during 2014-2016 comprised ≅ 28,600 cases and claimed ≅ 11,300 lives (1). The case-fatality rate (CFR) was high for Ebola virus [...]
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- 2016
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5. Highlights 2021: line of sight
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Palmer, Joanna, primary, Lahariya, Chandrakant, additional, Jah, Hawanatu, additional, Kongira, Fatoumata, additional, Idris, Yahaya, additional, Dodd, Savannah, additional, Nasca, Melita M, additional, Kent, James Clifford, additional, Gonzalez Cárdenas, Hugo Rolando, additional, Kumar, Alexander, additional, Bellizzi, Saverio, additional, Ohene-Frempong, Kwaku, additional, Odetola, Folafoluwa, additional, Beaumont, Nicolas, additional, Senavirathna, Samantha Kumara, additional, Geeganage, Saranga Dinusha, additional, Abeysinghe, Padmakumari, additional, Bawaskar, Himmatrao Saluba, additional, Bawaskar, Promodini Himmatrao, additional, Gan, Pearl, additional, Hapugoda, Menaka, additional, Sharma, Sanjib Kumar, additional, Balasubramanya, KV, additional, Pati, Manoj Kumar, additional, and N, Swaroop, additional
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- 2021
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6. Establishing and operating a ‘virtual ward’ system to provide care for patients with COVID-19 at home: experience from The Gambia
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Wariri, Oghenebrume, primary, Okomo, Uduak, additional, Cerami, Carla, additional, Okoh, Emmanuel, additional, Oko, Francis, additional, Jah, Hawanatu, additional, Bojang, Kalifa, additional, Susso, Bubacarr, additional, Olatunji, Yekini, additional, Nkereuwem, Esin, additional, Akemokwe, Fatai Momodou, additional, Jobe, Modou, additional, Agboghoroma, Orighomisan Freda, additional, Kebbeh, Bunja, additional, Sowe, Ghata, additional, Gilleh, Thomas, additional, Jobe, Naffie, additional, Usuf, Effua, additional, Clarke, Ed, additional, Brotherton, Helen, additional, and Forrest, Karen, additional
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- 2021
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7. Highlights 2021: line of sight
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Lahariya, Chandrakant, Jah, Hawanatu, Kongira, Fatoumata, Idris, Yahaya, Dodd, Savannah, Nasca, Melita M, Kent, James Clifford, Gonzalez Cárdenas, Hugo Rolando, Kumar, Alexander, Bellizzi, Saverio, Ohene-Frempong, Kwaku, Odetola, Folafoluwa, Beaumont, Nicolas, Senavirathna, Samantha Kumara, Geeganage, Saranga Dinusha, Abeysinghe, Padmakumari, Bawaskar, Himmatrao Saluba, Bawaskar, Promodini Himmatrao, Gan, Pearl, Hapugoda, Menaka, Sharma, Sanjib Kumar, Balasubramanya, KV, Pati, Manoj Kumar, N, Swaroop, and Palmer, Joanna
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- 2021
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8. Development of a pediatric Ebola predictive score, Sierra Leone
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Fitzgerald, Felicity, Wing, Kevin, Naveed, Asad, Gbessay, Musa, Ross, J C G, Checchi, Francesco, Youkee, Daniel, Jalloh, Mohamed Boie, Baion, David E, Mustapha, Ayeshatu, Jah, Hawanatu, Lako, Sandra, Oza, Shefali, Boufkhed, Sabah, Feury, Reynold, Bielicki, Julia, Williamson, Elizabeth, Gibb, Diana M, Klein, Nigel, Sahr, Foday, and Yeung, Shunmay
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SYMPTOMS ,pediatrics ,Adolescent ,Immunology ,lcsh:Medicine ,Ebola virus disease ,CHILDREN ,ResearchInstitutes_Networks_Beacons/humanitarian_conflict_response_institute ,RETROSPECTIVE COHORT ,child mortality ,Microbiology ,VALIDATION ,lcsh:Infectious and parasitic diseases ,Sierra Leone ,Disease Outbreaks ,1117 Public Health and Health Services ,Cohort Studies ,HOLDING UNITS ,Ebola virus ,Risk Factors ,1108 Medical Microbiology ,CASE-DEFINITION ,Humans ,lcsh:RC109-216 ,viruses ,viral hemorrhagic fever ,Child ,Retrospective Studies ,RISK ,OUTCOMES ,Science & Technology ,Research ,CLINICAL-FEATURES ,lcsh:R ,Infant ,1103 Clinical Sciences ,prediction ,Hemorrhagic Fever, Ebola ,Ebolavirus ,Development of a Pediatric Ebola Predictive Score, Sierra Leone ,Infectious Diseases ,Child, Preschool ,Humanitarian and Conflict Response Institute ,Hemorrhagic Fever, Ebola/diagnosis ,Sierra Leone/epidemiology ,Life Sciences & Biomedicine ,VIRUS DISEASE ,case definition - Abstract
We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children
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- 2017
9. The contribution of qualitative research within the PRECISE study in sub-Saharan Africa.
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Daniele, Marina A. S., Martinez-Alvarez, Melisa, Etyang, Angela Koech, Vidler, Marianne, Salisbury, Tatiana, Makanga, Prestige Tatenda, Musitia, Peris, Flint-O'Kane, Meriel, Brown, Tanya Wells, Diallo, Brahima Amara, Boene, Helena, Stones, William, von Dadelszen, Peter, Magee, Laura A., Sandall, Jane, the PRECISE Network, D'Alessandro, Umberto, Roca, Anna, Jah, Hawanatu, and Oguchukwu, Ofordile
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CHILD health services ,MATERNAL health services ,MENTAL health ,PLACENTA diseases ,RISK assessment ,QUALITATIVE research ,DISEASE risk factors - Abstract
The PRECISE Network is a cohort study established to investigate hypertension, fetal growth restriction and stillbirth (described as "placental disorders") in Kenya, Mozambique and The Gambia. Several pregnancy or birth cohorts have been set up in low- and middle-income countries, focussed on maternal and child health. Qualitative research methods are sometimes used alongside quantitative data collection from these cohorts. Researchers affiliated with PRECISE are also planning to use qualitative methods, from the perspective of multiple subject areas. This paper provides an overview of the different ways in which qualitative research methods can contribute to achieving PRECISE's objectives, and discusses the combination of qualitative methods with quantitative cohort studies more generally. We present planned qualitative work in six subject areas (health systems, health geography, mental health, community engagement, the implementation of the TraCer tool, and respectful maternity care). Based on these plans, with reference to other cohort studies on maternal and child health, and in the context of the methodological literature on mixed methods approaches, we find that qualitative work may have several different functions in relation to cohort studies, including informing the quantitative data collection or interpretation. Researchers may also conduct qualitative work in pursuit of a complementary research agenda. The degree to which integration between qualitative and quantitative methods will be sought and achieved within PRECISE remains to be seen. Overall, we conclude that the synergies resulting from the combination of cohort studies with qualitative research are an asset to the field of maternal and child health. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Harnessing the PRECISE network as a platform to strengthen global capacity for maternal and child health research in sub-Saharan Africa.
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Flint-O'Kane, Meriel, von Dadelszen, Peter, Makanga, Prestige Tatenda, Sevene, Esperança, Roca, Anna, Dukes, Peter, Hinrichs-Krapels, Saba, Craik, Rachel, Magee, Laura A., Temmerman, Marleen, The PRECISE Network, D'Alessandro, Umberto, Jah, Hawanatu, Oguchukwu, Ofordile, Prentice, Andrew, Martinez-Alvarez, Melisa, Diallo, Brahima, Sesey, Adbul, Lette, Kodou, and Bah, Alpha
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CHILD health services ,CLINICAL medicine research ,LEADERSHIP ,MATERNAL health services ,PLACENTA diseases ,RISK assessment ,DISEASE risk factors - Abstract
It is widely acknowledged across the global health sector that research programmes need to be designed and implemented in a way that maximise opportunities for strengthening local capacity. This paper examines how the United Kingdom Research and Innovation (UKRI) Grand Challenges Research Fund (GCRF) funded PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network has been established as a platform to strengthen global capacity for research focused on the improvement of maternal, fetal and newborn health in sub-Saharan Africa. Best practice principles outlined in an ESSENCE on Health Research report have been considered in relation to the PRECISE Network capacity-building activities described in this paper. These activities are described at the individual, programmatic and institutional levels, and successes, challenges and recommendations for future work are outlined. The paper concludes that the PRECISE leadership have an opportunity to review and refresh activity plans for capacity building at this stage in the project to build on achievements to date. [ABSTRACT FROM AUTHOR]
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- 2020
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11. PRECISE pregnancy cohort: challenges and strategies in setting up a biorepository in sub-Saharan Africa.
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Craik, Rachel, Russell, Donna, Tribe, Rachel M., Poston, Lucilla, Omuse, Geoffrey, Okiro, Patricia, Chege, David, Diatta, Mathurin, Sesay, Abdul Karim, Cuamba, Inocencia, Carrilho, Carla, Sevene, Esperança, Flint-O'Kane, Meriel, von Dadelszen, Peter, The PRECISE Network, D'Alessandro, Umberto, Roca, Anna, Jah, Hawanatu, Ogochukwu, Ofordile, and Prentice, Andrew
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FETAL growth retardation -- Risk factors ,RISK factors of preeclampsia ,PERINATAL death ,BIOMARKERS ,COMMUNICATION ,INTERPROFESSIONAL relations ,LONGITUDINAL method ,MATERNAL health services ,EVALUATION of medical care ,MEDICAL protocols ,PLACENTA diseases ,PREGNANCY ,PREGNANT women ,RISK assessment ,ADULT education workshops ,DISEASE risk factors - Abstract
Background and objective: PRECISE is a population-based, prospective pregnancy cohort study designed for deep phenotyping of pregnancies in women with placenta-related disorders, and in healthy controls. The PRECISE Network is recruiting ~ 10,000 pregnant women in three countries (The Gambia, Kenya, and Mozambique) representing sub-Saharan Africa. The principal aim is to improve our understanding of pre-eclampsia, fetal growth restriction and stillbirth. This involves the creation of a highly curated biorepository for state of the art discovery science and a rich database of antenatal variables and maternal and neonatal outcomes. Our overarching aim is to provide large sample numbers with adequate power to address key scientific questions. Here we describe our experience of establishing a biorepository in the PRECISE Network and review the issues and challenges surrounding set-up, management and scientific use. Methods: The feasibility of collecting and processing each sample type was assessed in each setting and plans made for establishing the necessary infrastructure. Quality control (QC) protocols were established to ensure that biological samples are 'fit-for-purpose'. The management structures required for standardised sample collection and processing were developed. This included the need for transport of samples between participating countries and to external academic/commercial institutions. Results: Numerous practical challenges were encountered in setting up the infrastructure including facilities, staffing, training, cultural barriers, procurement, shipping and sample storage. Whilst delaying the project, these were overcome by establishing good communication with the sites, training workshops and constant engagement with the necessary commercial suppliers. A Project Executive Committee and Biology Working Group together defined the biospecimens required to answer the research questions paying particular attention to harmonisation of protocols with other cohorts so as to enable cross-biorepository collaboration. Governance structures implemented include a Data and Sample Committee to ensure biospecimens and data will be used according to consent, and prioritisation by scientific excellence. A coordinated sample and data transfer agreement will prevent delay in sample sharing. Discussion: With adequate training and infrastructure, it is possible to establish high quality sample collections to facilitate research programmes such as the PRECISE Network in sub-Saharan Africa. These preparations are pre-requisites for effective execution of a biomarker-based approach to better understand the complexities of placental disease in these settings, and others. [ABSTRACT FROM AUTHOR]
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- 2020
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12. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) database: open-access data collection in maternal and newborn health.
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Magee, Laura A., Strang, Amber, Li, Larry, Tu, Domena, Tumtaweetikul, Warancha, Craik, Rachel, Daniele, Marina, Etyang, Angela Koech, D'Alessandro, Umberto, Ogochukwu, Ofordile, Roca, Anna, Sevene, Esperança, Chin, Paulo, Tchavana, Corssino, Temmerman, Marleen, von Dadelszen, Peter, The PRECISE Network, Jah, Hawanatu, Oguchukwu, Ofordile, and Prentice, Andrew
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DIAGNOSIS of HIV infections ,BLOOD pressure measurement ,CHILD health services ,CLINICAL medicine research ,EPIDEMIOLOGICAL research ,INFANT mortality ,MEDICAL databases ,INFORMATION storage & retrieval systems ,IRON compounds ,MATERNAL health services ,EVALUATION of medical care ,MEDICAL laboratories ,MENTAL health ,MATERNAL mortality ,NUTRITION ,PLACENTA diseases ,POSTNATAL care ,PREGNANCY ,RESUSCITATION ,RISK assessment ,COMORBIDITY ,SOCIOECONOMIC factors ,CONTENT mining ,HEALTH & social status ,DISEASE risk factors - Abstract
In less-resourced settings, adverse pregnancy outcome rates are unacceptably high. To effect improvement, we need accurate epidemiological data about rates of death and morbidity, as well as social determinants of health and processes of care, and from each country (or region) to contextualise strategies. The PRECISE database is a unique core infrastructure of a generic, unified data collection platform. It is built on previous work in data harmonisation, outcome and data field standardisation, open-access software (District Health Information System 2 and the Baobab Laboratory Information Management System), and clinical research networks. The database contains globally-recommended indicators included in Health Management Information System recording and reporting forms. It comprises key outcomes (maternal and perinatal death), life-saving interventions (Human Immunodeficiency Virus testing, blood pressure measurement, iron therapy, uterotonic use after delivery, postpartum maternal assessment within 48 h of birth, and newborn resuscitation, immediate skin-to-skin contact, and immediate drying), and an additional 17 core administrative variables for the mother and babies. In addition, the database has a suite of additional modules for 'deep phenotyping' based on established tools. These include social determinants of health (including socioeconomic status, nutrition and the environment), maternal co-morbidities, mental health, violence against women and health systems. The database has the potential to enable future high-quality epidemiological research integrated with clinical care and discovery bioscience. [ABSTRACT FROM AUTHOR]
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- 2020
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13. The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network's first protocol: deep phenotyping in three sub-Saharan African countries.
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von Dadelszen, Peter, Flint-O'Kane, Meriel, Poston, Lucilla, Craik, Rachel, Russell, Donna, Tribe, Rachel M., d'Alessandro, Umberto, Roca, Anna, Jah, Hawanatu, Temmerman, Marleen, Koech Etyang, Angela, Sevene, Esperança, Chin, Paulo, Lawn, Joy E., Blencowe, Hannah, Sandall, Jane, Salisbury, Tatiana T., Barratt, Benjamin, Shennan, Andrew H., and Makanga, Prestige Tatenda
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FETAL growth retardation -- Risk factors ,RISK factors of preeclampsia ,PERINATAL death ,BIOMARKERS ,CHILD health services ,GESTATIONAL age ,HYPERTENSION in pregnancy ,MATERNAL health services ,MEDICAL protocols ,PLACENTA diseases ,PREGNANCY complications ,PRENATAL care ,PUERPERIUM ,PSYCHOLOGICAL resilience ,RISK assessment ,SUSTAINABLE development ,PHENOTYPES ,SAMPLE size (Statistics) ,HEALTH & social status ,DISEASE risk factors - Abstract
Background: The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is a new and broadly-based group of research scientists and health advocates based in the UK, Africa and North America. Methods: This paper describes the protocol that underpins the clinical research activity of the Network, so that the investigators, and broader global health community, can have access to 'deep phenotyping' (social determinants of health, demographic and clinical parameters, placental biology and agnostic discovery biology) of women as they advance through pregnancy to the end of the puerperium, whether those pregnancies have normal outcomes or are complicated by one/more of the placental disorders of pregnancy (pregnancy hypertension, fetal growth restriction and stillbirth). Our clinical sites are in The Gambia (Farafenni), Kenya (Kilifi County), and Mozambique (Maputo Province). In each country, 50 non-pregnant women of reproductive age will be recruited each month for 1 year, to provide a final national sample size of 600; these women will provide culturally-, ethnically-, seasonally- and spatially-relevant control data with which to compare women with normal and complicated pregnancies. Between the three countries we will recruit ≈10,000 unselected pregnant women over 2 years. An estimated 1500 women will experience one/more placental complications over the same epoch. Importantly, as we will have accurate gestational age dating using the TraCer device, we will be able to discriminate between fetal growth restriction and preterm birth. Recruitment and follow-up will be primarily facility-based and will include women booking for antenatal care, subsequent visits in the third trimester, at time-of-disease, when relevant, during/immediately after birth and 6 weeks after birth. Conclusions: To accelerate progress towards the women's and children's health-relevant Sustainable Development Goals, we need to understand how a variety of social, chronic disease, biomarker and pregnancy-specific determinants health interact to result in either a resilient or a compromised pregnancy for either mother or fetus/newborn, or both. This protocol has been designed to create such a depth of understanding. We are seeking funding to maintain the cohort to better understand the implications of pregnancy complications for both maternal and child health. [ABSTRACT FROM AUTHOR]
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- 2020
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14. Refining the paediatric Ebola case definition: a study of children in Sierra Leone with suspected Ebola virus disease
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Fitzgerald, Felicity, primary, Wing, Kevin, additional, Naveed, Asad, additional, Gbessay, Musa, additional, Ross, J C G, additional, Checchi, Francesco, additional, Youkee, Daniel, additional, Jalloh, Mohammed Boie, additional, Baion, David, additional, Mustapha, Ayeshatu, additional, Jah, Hawanatu, additional, Lako, Sandra, additional, Oza, Shefali, additional, Boufkhed, Sabah, additional, Feury, Reynold, additional, Bielicki, Julia, additional, Williamson, Elizabeth, additional, Gibb, Diana M, additional, Klein, Nigel, additional, Sahr, Foday, additional, and Yeung, Shunmay, additional
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- 2017
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15. Ebola virus disease in children in Sierra Leone: a retrospective cohort study
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Fitzgerald, Felicity, primary, Naveed, Asad, additional, Wing, Kevin, additional, Gbessay, Musa, additional, Ross, Gareth, additional, Checchi, Francesco, additional, Youkee, Daniel, additional, Jalloh, Mohammed, additional, Baion, David, additional, Mustapha, Ayeshatu, additional, Jah, Hawanatu, additional, Lako, Sandra, additional, Oza, Shefali, additional, Boufkhed, Sabah, additional, Feury, Reynold, additional, Bielicki, Julia, additional, Gibb, Diana, additional, Klein, Nigel, additional, Sahr, Foday, additional, and Yeung, Shunmay, additional
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- 2016
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16. Development of a Pediatric Ebola Predictive Score, Sierra Leone1.
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Fitzgerald, Felicity, Wing, Kevin, Naveed, Asad, Gbessay, Musa, Ross, J. C. G., Checchi, Francesco, Youkee, Daniel, Jalloh, Mohamed Boie, Baion, David E., Mustapha, Ayeshatu, Jah, Hawanatu, Lako, Sandra, Oza, Shefali, Boufkhed, Sabah, Feury, Reynold, Bielicki, Julia, Williamson, Elizabeth, Gibb, Diana M., Klein, Nigel, and Sahr, Foday
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EBOLA viral disease transmission ,PEDIATRICS ,LOGISTIC regression analysis ,SENSITIVITY analysis - Abstract
We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%-90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required. [ABSTRACT FROM AUTHOR]
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- 2018
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17. Development of a Pediatric Ebola Predictive Score, Sierra Leone1.
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Fitzgerald, Felicity, Wing, Kevin, Naveed, Asad, Gbessay, Musa, Ross, J. C. G., Checchi, Francesco, Youkee, Daniel, Jalloh, Mohamed Boie, Baion, David E., Mustapha, Ayeshatu, Jah, Hawanatu, Lako, Sandra, Oza, Shefali, Boufkhed, Sabah, Feury, Reynold, Bielicki, Julia, Williamson, Elizabeth, Gibb, Diana M., Klein, Nigel, and Sahr, Foday
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EBOLA viral disease transmission , *PEDIATRICS , *LOGISTIC regression analysis , *SENSITIVITY analysis - Abstract
We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%-90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required. [ABSTRACT FROM AUTHOR]
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- 2018
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18. The PRECISE-DYAD Neurodevelopmental substudy protocol: neurodevelopmental risk in children of mothers with pregnancy complications.
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Magai DN, Chandna J, Volvert ML, Craik R, Jah H, Kongira F, Bojang K, Koech A, Mwashigadi G, Mutua AM, Blencowe H, D'Alessandro U, Roca A, Temmerman M, von Dadelszen P, Abubakar A, and Gladstone M
- Abstract
Background: Over 250 million children are not reaching their developmental potential globally. The impact of prenatal factors and their interplay with postnatal environmental factors on child neurodevelopment, is still unclear-particularly in low- and middle-income settings. This study aims to understand the impact of pregnancy complications as well as environmental, psychosocial, and biological predictors on neurodevelopmental trajectories., Methods: This is an observational cohort study of female and male children (≈3,950) born to women (≈4,200) with and without pregnancy complications (pregnancy-induced hypertension, foetal growth restriction, and premature birth) previously recruited into PREgnancy Care Integrating Translational Science, Everywhere study with detailed biological data collected in intrapartum and post-partum periods. Children will be assessed at six weeks to 6 months, 11-13 months, 23-25 months and 35-37 months in rural and semi-urban Gambia (Farafenni, Illiasa, and Ngayen Sanjal) and Kenya (Mariakani and Rabai). We will assess children's neurodevelopment using Prechtls General Movement Assessment, the Malawi Development Assessment Tool (primary outcome), Observation of Maternal-Child Interaction, the Neurodevelopmental Disorder Screening Tool, and the Epilepsy Screening tool. Children screening positive will be assessed with Cardiff cards (vision), Modified Checklist for Autism in Toddlers Revised, and Pediatric Quality of Life Inventory Family Impact. We will use multivariate logistic regression analysis to investigate the impact of pregnancy complications on neurodevelopment and conduct structural equation modelling using latent class growth to study trajectories and relationships between biological, environmental, and psychosocial factors on child development., Conclusions: We aim to provide information regarding the neurodevelopment of infants and children born to women with and without pregnancy complications at multiple time points during the first three years of life in two low-resource African communities. A detailed evaluation of developmental trajectories and their predictors will provide information on the most strategic points of intervention to prevent and reduce the incidence of neurodevelopmental impairments., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Magai DN et al.)
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- 2024
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19. The PRECISE-DYAD protocol: linking maternal and infant health trajectories in sub-Saharan Africa.
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Craik R, Volvert ML, Koech A, Jah H, Pickerill K, Abubakar A, D'Alessandro U, Barratt B, Blencowe H, Bone JN, Chandna J, Gladstone MJ, Khalil A, Li L, Magee LA, Makacha L, Mistry HD, Moore SE, Roca A, Salisbury TT, Temmerman M, Toudup D, Vidler M, and von Dadelszen P
- Abstract
Background: PRECISE-DYAD is an observational cohort study of mother-child dyads running in urban and rural communities in The Gambia and Kenya. The cohort is being followed for two years and includes uncomplicated pregnancies and those that suffered pregnancy hypertension, fetal growth restriction, preterm birth, and/or stillbirth., Methods: The PRECISE-DYAD study will follow up ~4200 women and their children recruited into the original PRECISE study. The study will add to the detailed pregnancy information and samples in PRECISE, collecting additional biological samples and clinical information on both the maternal and child health.Women will be asked about both their and their child's health, their diets as well as undertaking a basic cardiology assessment. Using a case-control approach, some mothers will be asked about their mental health, their experiences of care during labour in the healthcare facility. In a sub-group, data on financial expenditure during antenatal, intrapartum, and postnatal periods will also be collected. Child development will be assessed using a range of tools, including neurodevelopment assessments, and evaluating their home environment and quality of life. In the event developmental milestones are not met, additional assessments to assess vision and their risk of autism spectrum disorders will be conducted. Finally, a personal environmental exposure model for the full cohort will be created based on air and water quality data, combined with geographical, demographic, and behavioural variables., Conclusions: The PRECISE-DYAD study will provide a greater epidemiological and mechanistic understanding of health and disease pathways in two sub-Saharan African countries, following healthy and complicated pregnancies. We are seeking additional funding to maintain this cohort and to gain an understanding of the effects of pregnancies outcome on longer-term health trajectories in mothers and their children., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Craik R et al.)
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- 2024
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