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This work presents a rigorous mathematical formulation for topology optimization of a macro structure undergoing ductile failure. The prediction of ductile solid materials which exhibit dominant plastic deformation is an intriguingly challenging task and plays an extremely important role in various engineering applications. Here, we rely on the phase-field approach to fracture which is a widely adopted framework for modeling and computing the fracture failure phenomena in solids. The first objective is to optimize the topology of the structure in order to minimize its mass, while accounting for structural damage. To do so, the topological phase transition function (between solid and void phases) is introduced, thus resulting in an extension of all the governing equations. Our second objective is to additionally enhance the fracture resistance of the structure. Accordingly, two different formulations are proposed. One requires only the residual force vector of the deformation field as a constraint, while in the second formulation, the residual force vector of the deformation and phase-field fracture simultaneously have been imposed. An incremental minimization principles for a class of gradient-type dissipative materials are used to derive the governing equations. Thereafter, to obtain optimal topology to enhance the structural resistance due to fracture, the level-set-based formulation is formulated. The level-set-based topology optimization is employed to seek an optimal layout with smooth and clear boundaries. Sensitivities are derived using the analytical gradient-based adjoint method to update the level-set surface for both formulations. Here, the evolution of the level-set surface is realized by the reaction–diffusion equation to maximize the strain energy of the structure while a certain volume of design domain is prescribed. Several three-dimensional numerical examples are presented to substantiate our algorithmic developments. [ABSTRACT FROM AUTHOR]