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2. Can pelvic floor muscle function before surgery determine the outcome of surgical treatment of stress urinary incontinence in women?

Author

Szymański, Jacek K., Krawczyk, Agata, Starzec‐Proserpio, Małgorzata, Raczkiewicz, Dorota, Kukulski, Piotr, and Jakiel, Grzegorz

Subjects
URINARY stress incontinence, URINARY incontinence in women, PELVIC floor, PREHABILITATION, COUGH, KEGEL exercises
Abstract

Aim: The study aimed to determine whether pelvic floor muscle (PFM) function before surgery may correlate with the success of surgical interventions for treating stress urinary incontinence (SUI). Our hypothesis was that addressing identified variables in preoperative rehabilitation could potentially improve surgical outcomes. Methods: This prospective observational study was conducted at a single center and enrolled women qualified to mid‐urethral tape insertion for SUI between 2020 and 2022. Digital palpation and manometry (Peritron™ 9300 V) were used to evaluate PFM function. The following parameters were acquired: vaginal resting pressure, vaginal pressure during maximal voluntary contraction (MVC), the area under the curve during a 10‐second MVC, moreover the ability to perform correct PFM contraction, reflexive PFM contraction during cough and relaxation were assessed. All measurements were performed before the surgical treatment and during follow‐up assessments at 1, 3, and 6 months postoperatively. The primary endpoint of the study was defined as objective cure, characterized by a negative cough stress test (CST), along with a subjective assessment based on the Urogenital Distress Inventory‐6 (UDI‐6) and Incontinence Impact Questionnaire‐7 (IIQ‐7). Results: The study involved 57 eligible female participants, all of whom completed the 6‐month follow‐up. Objective cure was observed in 75.44% of cases, while subjective cure was reported in 33%. There was no association between PFM parameters and surgical outcomes. Conclusion: The success of surgical treatment of SUI 6 months postsurgery is not related to preoperative pelvic floor muscle function. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Follicular Fluid Proteomic Analysis to Identify Predictive Markers of Normal Embryonic Development.

Author

Przewocki, Janusz, Kossiński, Dominik, Łukaszuk, Adam, Jakiel, Grzegorz, Wocławek-Potocka, Izabela, Ołdziej, Stanisław, and Łukaszuk, Krzysztof

Subjects
EMBRYOLOGY, OVUM donation, CYTOSKELETAL proteins, MASS spectrometers, MASS spectrometry
Abstract

Ageing populations, mass "baby-free" policies and children born to mothers at the age at which they are biologically expected to become grandmothers are growing problems in most developed societies. Therefore, any opportunity to improve the quality of infertility treatments seems important for the survival of societies. The possibility of indirectly studying the quality of developing oocytes by examining their follicular fluids (hFFs) offers new opportunities for progress in our understanding the processes of final oocyte maturation and, consequently, for predicting the quality of the resulting embryos and personalising their culture. Using mass spectrometry, we studied follicular fluids collected individually during in vitro fertilisation and compared their composition with the quality of the resulting embryos. We analysed 110 follicular fluids from 50 oocyte donors, from which we obtained 44 high-quality, 39 medium-quality, and 27 low-quality embryos. We identified 2182 proteins by Sequential Window Acquisition of all Theoretical Mass Spectra (SWATH-MS) using a TripleTOF 5600+ hybrid mass spectrometer, of which 484 were suitable for quantification. We were able to identify several proteins whose concentrations varied between the follicular fluids of different oocytes from the same patient and between patients. Among them, the most important appear to be immunoglobulin heavy constant alpha 1 (IgA1hc) and dickkopf-related protein 3. The first one is found at higher concentrations in hFFs from which oocytes develop into poor-quality embryos, the other one exhibits the opposite pattern. None of these have, so far, had any specific links to fertility disorders. In light of these findings, these proteins should be considered a primary target for research aimed at developing a diagnostic tool for oocyte quality control and pre-fertilisation screening. This is particularly important in cases where the fertilisation of each egg is not an option for ethical or other reasons, or in countries where it is prohibited by law. [ABSTRACT FROM AUTHOR]

Published
2024
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5. The effect of ulipristal acetate on tumor necrosis factor α, insulin-like growth factor 1, and plasminogen activator inhibitor-1 serum levels in patients with symptomatic uterine fibroids.

Author

Ciebiera, Michał, Jakiel, Grzegorz, Nowicka, Grażyna, Laganà, Antonio Simone, Ghezzi, Fabio, Łoziński, Tomasz, Wojtyła, Cezary, and Włodarczyk, Marta

Subjects
*SOMATOMEDIN C, *TUMOR necrosis factors, *PLASMINOGEN activators, *UTERINE fibroids, *PROGESTERONE receptors, *SMOOTH muscle tumors
Abstract

Introduction: Uterine fibroids (UFs) are benign tumors of the female reproductive system originating from the smooth muscle of the uterus. Currently, progesterone is known to play a key role in the differentiation of the myometrial tissue to form UFs and their abnormal growth. The mechanism of action of progesterone in UF tumorigenesis involves its effect on increasing the concentrations and dysregulation of selected growth factors. Material and methods: A retrospective cohort study was performed to evaluate and compare tumor necrosis factor a (TNF-α), insulin-like growth factor 1 (IGF-1), plasminogen activator inhibitor-1 (PAI-1) serum concentrations in patients with UFs without prior hormonal treatment, patients with UFs treated with a 3-month standard ulipristal acetate (UPA - a type of selective progesterone receptor modulator) scheme (5 mg/day) and in control patients without UFs. A total of 120 patients were divided into 3 groups (controls, UFs with UPA treatment, UFs without UPA treatment). Results: There were no significant differences in TNF-α serum concentrations between patients with UFs who underwent UPA treatment and patients who did not. Serum concentrations of IGF-1 and PAI-1 did not show significant intergroup differences. Conclusions: No significant differences were found between TNF-α concentrations in the serum of patients with UFs treated with UPA, and patients without UPA treatment. In addition, our data analysis did not show significant differences in the concentrations of IGF-1 and PAI-1 between patients with UFs and the control group. Further studies on the dependence of specific symptoms on selected growth factors are mandatory. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Is Growth Restriction in Twin Pregnancies a Double Challenge? – A Narrative Review

Author

Filipecka-Tyczka, Dagmara, Jakiel, Grzegorz, Kajdy, Anna, and Rabijewski, Michał

Subjects
Fetal Growth Retardation, Case Study, definitions, Placenta, hypotrophy, Infant, Newborn, twins, Twins, Monozygotic, Placental Insufficiency, twin pregnancies, foetal growth restriction, Pregnancy, Pregnancy, Twin, Humans, Female, reproductive and urinary physiology, management
Abstract

Background Foetal growth restriction (FGR) complicates about 25–47% of twin pregnancies. One or both foetuses can be restricted. Pregnancies with discordant growth of foetuses are associated with a sevenfold increased risk of neonatal morbidity. Materials and methods This is a narrative or traditional literature review. A literature search was performed to present a comprehensive, critical and objective analysis of the current knowledge on growth restriction in twin pregnancies. Results The definitions of FGR in twin pregnancies and selective FGR (sFGR) differ between international societies. In 2019, the Delphi procedure aimed to unify the definitions of sFGR in twin pregnancies. Several growth charts for twins have been published. However, most societies recommend singleton growth charts as better in detecting hypoxic complications of FGR in twin pregnancies. Discordant growth in twins results from placental insufficiency, congenital anomalies, chromosomal aberrations and TORCH infections. Conclusions Definitions and management of sFGR depend on chorionicity. The management aims to protect the properly growing foetus from ischemic complications or in utero death. In most cases, expectant management, strict surveillance and preterm labour are the methods of choice. Due to the co-existence of properly growing and small foetuses in one uterus, determining the appropriate time for delivery is challenging. In the case of preterm labour, even late preterm, antenatal corticosteroid therapy (ACT) in FGR twin pregnancies is beneficial because it decreases neonatal morbidity.

Published
2021

21. IMSI—Guidelines for Sperm Quality Assessment

Author

Lukaszuk, Krzysztof, primary, Jakiel, Grzegorz, additional, Wocławek Potocka, Izabela, additional, Kiewisz, Jolanta, additional, Olszewska, Jolanta, additional, Sieg, Wlodzimierz, additional, Podolak, Amira, additional, Pastuszek, Ewa, additional, and Wdowiak, Artur, additional

Published
2022
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43. Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?

Author

Słabuszewska-Jóżwiak, Aneta, primary, Włodarczyk, Marta, additional, Kilian, Krzysztof, additional, Rogulski, Zbigniew, additional, Ciebiera, Michał, additional, Szymańska-Majchrzak, Jolanta, additional, Zaręba, Kornelia, additional, Szymański, Jacek Krzysztof, additional, Raczkiewicz, Dorota, additional, Nowicka, Grażyna, additional, and Jakiel, Grzegorz, additional

Published
2020
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