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3. Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study

Author

Bauer, Franz, Berbec, Nicoleta, Besses Raebel, Carlos, Borbenyi, Zita, Bumbea, Horia, Buxhofer-Ausch, Veronika, Calbecka, Malgorzata, Cayssials-Caylus, Emilie, Cazzola, Mario, Cerna, Olga, Cucuianu, Andrei, Dima, Delia Monica, Forjan, Ernst, Gheorghita, Emanuil, Greil, Richard, Hatalova, Antonia, Hrubisko, Mikulas, Jakucs, Janos, Kaplan, Polina, Klymenko, Sergiy, Koschmieder, Steffen, Lazaroiu, Mihaela, Lysa, Tamila, Masliak, Zvenyslava, Masszi, Tamas, Mihaylov, Georgi, Myasnikov, Alexander, Platzbecker, Uwe, Puyade, Mathieu, Rey, Jerome, Roy, Lydia, Schwarz, Jiri, Skotnicki, Aleksander, Sokolova, Irina, Soroka-Wojtaszko, Maria, Starzak-Gwozdz, Jolanta, Stoeva, Vera, Torregrosa-Diaz, Jose Miguel, Vallova, Anna, Volodicheva, Elena, Warzocha, Krzysztof, Willenbacher, Ella, Wolf, Dominik, Gisslinger, Heinz, Klade, Christoph, Georgiev, Pencho, Krochmalczyk, Dorota, Gercheva-Kyuchukova, Liana, Egyed, Miklos, Rossiev, Viktor, Dulicek, Petr, Illes, Arpad, Pylypenko, Halyna, Sivcheva, Lylia, Mayer, Jiri, Yablokova, Vera, Krejcy, Kurt, Grohmann-Izay, Barbara, Hasselbalch, Hans C, Kralovics, Robert, and Kiladjian, Jean-Jacques

Published
2020
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4. Pacritinib versus best available therapy for the treatment of myelofibrosis irrespective of baseline cytopenias (PERSIST-1): an international, randomised, phase 3 trial

Author

Mesa, Ruben A, Vannucchi, Alessandro M, Mead, Adam, Egyed, Miklos, Szoke, Anita, Suvorov, Aleksandr, Jakucs, Janos, Perkins, Andrew, Prasad, Ritam, Mayer, Jiri, Demeter, Judit, Ganly, Peter, Singer, Jack W, Zhou, Huafeng, Dean, James P, te Boekhorst, Peter A, Nangalia, Jyoti, Kiladjian, Jean-Jacques, and Harrison, Claire N

Published
2017
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6. Rows with the neighbours: the short lives of longhouses at the Neolithic site of Versend-Gilencsa

Author

Jakucs, Janos, Oross, Krisztian, Banffy, Eszter, Voicsek, Vanda, Dunbar, Elaine, Reimer, Paula, Bayliss, Alex, and Whittle, Peter Marshall Alasdair

Subjects
Neolithic period -- Social aspects, Chronology -- Models -- Analysis, Housing -- Social aspects -- Discovery and exploration, Anthropology/archeology/folklore
Abstract

Longhouses are a key feature of Neolithic Linearbandkeramik (LBK) settlements in Central Europe, but debate persists concerning their usage, longevity and social significance. Excavations at Versend-Gilencsa in south-west Hungary (c. 5200 cal BC) revealed clear rows of longhouses. New radiocarbon dates suggest that these houses experienced short lifespans. This paper produces a model for the chronology of Versend, and it considers the implications of the new date estimates for a fuller understanding of the layout and duration of LBK longhouse settlements. Keywords: Hungary, Versend-Gilencsa, Neolithic, LBK, longhouses, Bayesian chronological modelling, Introduction Great timber longhouses are a defining feature of the first Neolithic communities in Central and Western Europe, belonging to the Linearbandkeramik (LBK) culture of the later sixth millennium cal [...]

Published
2018
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7. Tracing the genetic origin of Europe's first farmers reveals insights into their social organization

Author

Szécsényi-Nagy, Anna, Brandt, Guido, Haak, Wolfgang, Keerl, Victoria, Jakucs, János, Möller-Rieker, Sabine, Köhler, Kitti, Mende, Balázs Gusztáv, Oross, Krisztián, Marton, Tibor, Osztás, Anett, Kiss, Viktória, Fecher, Marc, Pálfi, György, Molnár, Erika, Sebők, Katalin, Czene, András, Paluch, Tibor, Šlaus, Mario, Novak, Mario, Pećina-Šlaus, Nives, Ősz, Brigitta, Voicsek, Vanda, Somogyi, Krisztina, Tóth, Gábor, Kromer, Bernd, Bánffy, Eszter, and Alt, Kurt W.

Published
2015

8. Ropeginterferon alfa-2b versus standard therapy for polycythaemia vera (PROUD-PV and CONTINUATION-PV): a randomised, non-inferiority, phase 3 trial and its extension study

Author

Gisslinger, Heinz, primary, Klade, Christoph, additional, Georgiev, Pencho, additional, Krochmalczyk, Dorota, additional, Gercheva-Kyuchukova, Liana, additional, Egyed, Miklos, additional, Rossiev, Viktor, additional, Dulicek, Petr, additional, Illes, Arpad, additional, Pylypenko, Halyna, additional, Sivcheva, Lylia, additional, Mayer, Jiri, additional, Yablokova, Vera, additional, Krejcy, Kurt, additional, Grohmann-Izay, Barbara, additional, Hasselbalch, Hans C, additional, Kralovics, Robert, additional, Kiladjian, Jean-Jacques, additional, Bauer, Franz, additional, Berbec, Nicoleta, additional, Besses Raebel, Carlos, additional, Borbenyi, Zita, additional, Bumbea, Horia, additional, Buxhofer-Ausch, Veronika, additional, Calbecka, Malgorzata, additional, Cayssials-Caylus, Emilie, additional, Cazzola, Mario, additional, Cerna, Olga, additional, Cucuianu, Andrei, additional, Dima, Delia Monica, additional, Forjan, Ernst, additional, Gheorghita, Emanuil, additional, Greil, Richard, additional, Hatalova, Antonia, additional, Hrubisko, Mikulas, additional, Jakucs, Janos, additional, Kaplan, Polina, additional, Klymenko, Sergiy, additional, Koschmieder, Steffen, additional, Lazaroiu, Mihaela, additional, Lysa, Tamila, additional, Masliak, Zvenyslava, additional, Masszi, Tamas, additional, Mihaylov, Georgi, additional, Myasnikov, Alexander, additional, Platzbecker, Uwe, additional, Puyade, Mathieu, additional, Rey, Jerome, additional, Roy, Lydia, additional, Schwarz, Jiri, additional, Skotnicki, Aleksander, additional, Sokolova, Irina, additional, Soroka-Wojtaszko, Maria, additional, Starzak-Gwozdz, Jolanta, additional, Stoeva, Vera, additional, Torregrosa-Diaz, Jose Miguel, additional, Vallova, Anna, additional, Volodicheva, Elena, additional, Warzocha, Krzysztof, additional, Willenbacher, Ella, additional, and Wolf, Dominik, additional

Published
2020
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9. Seeking the Holy Grail

Author

Banffy, Eszter, primary, Bayliss, Alex, primary, Denaire, Anthony, primary, Gaydarska, Bisserka, primary, Hofmann, Daniela, primary, Lefranc, Philippe, primary, Jakucs, Janos, primary, Maric, Miroslav, primary, Oross, Krisztian, primary, Tasic, Nenad, primary, and Whittle, Alasdair, primary

Published
2019
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10. Seeking the Holy Grail: robust chronologies from archaeology and radiocarbon dating combined

Author

Banffy, Eszter, Bayliss, Alex, Denaire, Anthony, Gaydarska, Bisserka, Hofmann, D., Lefranc, P., Jakucs, Janos, Marić, Miroslav, Oross, Krisztian, Tasić, Nenad, Whittle, Alasdair, Banffy, Eszter, Bayliss, Alex, Denaire, Anthony, Gaydarska, Bisserka, Hofmann, D., Lefranc, P., Jakucs, Janos, Marić, Miroslav, Oross, Krisztian, Tasić, Nenad, and Whittle, Alasdair

Abstract

The strengths of formal Bayesian chronological modelling are restated, combining as it does knowledge of the archaeology with the radiocarbon dating of carefully chosen samples of known taphonomy in association with diagnostic material culture. The risks of dating bone samples are reviewed, along with a brief history of the development of approaches to the radiocarbon dating of bone. In reply to Strien (2017), selected topics concerned with the emergence and aftermath of the LBK are discussed, as well as the early Vin≠a, Ra∫i∏te and Hinkelstein sequences. The need for rigour in an approach which combines archaeology and radiocarbon dating is underlined.

Published
2018

11. A Vinca potscape: Formal chronological models for the use and development of Vinca ceramics in south-east Europe

Author

Whittle, Alasdair, Bayliss, Alex, Barclay, Alistair, Gaydarska, Bisserka, Banffy, Eszter, Borić, Dušan, Drasovean, F., Jakucs, Janos, Marić, Miroslav, Orton, David, Pantović, I., Schier, Wolfram, Tasić, Nenad, Linden, M.V., Whittle, Alasdair, Bayliss, Alex, Barclay, Alistair, Gaydarska, Bisserka, Banffy, Eszter, Borić, Dušan, Drasovean, F., Jakucs, Janos, Marić, Miroslav, Orton, David, Pantović, I., Schier, Wolfram, Tasić, Nenad, and Linden, M.V.

Abstract

Recent work at Vinca-Belo Brdo has combined a total of more than 200 radiocarbon dates with an array of other information to construct much more precise narratives for the structural history of the site and the cultural materials recovered from it. In this paper, we present the results of a recent attempt to construct formal models for the chronology of the wider Vinca potscape, so that we can place our now detailed understanding of changes at Belo Brdo within their contemporary contexts. We present our methodology for assessing the potential of the existing corpus of more than 600 radiocarbon dates for refining the chronology of the five phases of Vinca ceramics proposed by Milojcicic across their spatial ranges, including a total of 490 of them in a series of Bayesian chronological models. Then we outline our main results for the development of Vinca pottery. Finally, we discuss some of the major implications for our understanding of the source, character and tempo of material change.

Published
2016

12. Analysis of Outcomes By Patient Subgroups in Patients with Myelofibrosis Treated with Pacritinib Vs Best Available Therapy (BAT) in the Phase III Persist-1 Trial

Author

Vannucchi, Alessandro M., primary, Mesa, Ruben A., additional, Cervantes, Francisco, additional, Prasad, Ritam, additional, Jakucs, Janos, additional, Elinder, Anna, additional, Recher, Christian, additional, te Boekhorst, Peter A., additional, Knapper, Steven, additional, Somervaille, Tim, additional, Dean, James P., additional, Granston, Tanya, additional, Mead, Adam, additional, and Harrison, Claire N., additional

Published
2015
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13. Parallel paleogenomic transects reveal complex genetic history of early European farmers

Author

Lipson, Mark, Szécsényi-Nagy, Anna, Mallick, Swapan, Pósa, Annamária, Stégmár, Balázs, Keerl, Victoria, Rohland, Nadin, Stewardson, Kristin, Ferry, Matthew, Michel, Megan, Oppenheimer, Jonas, Broomandkhoshbacht, Nasreen, Harney, Eadaoin, Nordenfelt, Susanne, Llamas, Bastien, Mende, Balázs Gusztáv, Köhler, Kitti, Oross, Krisztián, Bondár, Mária, Marton, Tibor, Osztás, Anett, Jakucs, János, Paluch, Tibor, Horváth, Ferenc, Csengeri, Piroska, Koós, Judit, Sebők, Katalin, Anders, Alexandra, Raczky, Pál, Regenye, Judit, Barna, Judit P., Fábián, Szilvia, Serlegi, Gábor, Toldi, Zoltán, Nagy, Emese Gyöngyvér, Dani, János, Molnár, Erika, Pálfi, György, Márk, László, Melegh, Béla, Bánfai, Zsolt, Domboróczki, László, Fernández-Eraso, Javier, Mujika-Alustiza, José Antonio, Fernández, Carmen Alonso, Echevarría, Javier Jiménez, Bollongino, Ruth, Orschiedt, Jörg, Schierhold, Kerstin, Meller, Harald, Cooper, Alan, Burger, Joachim, Bánffy, Eszter, Alt, Kurt W., Lalueza-Fox, Carles, Haak, Wolfgang, and Reich, David

Abstract

Ancient DNA studies have established that Neolithic European populations were descended from Anatolian migrants1–8 who received a limited amount of admixture from resident hunter-gatherers3–5,9. Many open questions remain, however, about the spatial and temporal dynamics of population interactions and admixture during the Neolithic period. Using the highest-resolution genome-wide ancient DNA data set assembled to date—a total of 180 samples, 130 newly reported here, from the Neolithic and Chalcolithic of Hungary (6000–2900 BCE, n = 100), Germany (5500–3000 BCE, n = 42), and Spain (5500–2200 BCE, n = 38)—we investigate the population dynamics of Neolithization across Europe. We find that genetic diversity was shaped predominantly by local processes, with varied sources and proportions of hunter-gatherer ancestry among the three regions and through time. Admixture between groups with different ancestry profiles was pervasive and resulted in observable population transformation across almost all cultural transitions. Our results shed new light on the ways that gene flow reshaped European populations throughout the Neolithic period and demonstrate the potential of time-series-based sampling and modeling approaches to elucidate multiple dimensions of historical population interactions.

Published
2017
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14. Results of the Interim Analysis of the “HUSOM” Trial: Hungarian Study of Maintenance After Rituximab Pretreatment, A Multicentre, Phase III, Open-Label Study Evaluating the Benefit of a Long-Term MabThera (rituximab) Maintenance Therapy in Patients with Advance Follicular Lymphoma After Induction of Response (CR(u) or PR) with a MabThera (rituximab)-Containing First Line Regimen

Author

Schneider, Tamas J., Rosta, Andras, Losonczy, Hajna, Radvanyi, Gaspar, Ujj, Gyorgy, Illes, Arpad, Jakucs, János, and Borbenyi, Zita

Published
2011
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15. A randomized double-blind phase III pivotal study of febuxostat (FEB) versus allopurinol (ALL) in the prevention of tumor lysis syndrome (TLS): Florence study

Author

Spina, Michele, Nagy, Zsolt, Ribera, Josep M., Federico, Massimo, Aurer, Igor, Jordan, Karin, Borsaru, Gabriela, Pristupa, Alexander S., Bosi, Alberto, Grosicki, Sebastian, Glushko, Nataliia L., Ristic, Dusan, Jakucs, Janos, Mayer, Jiri, Eduardo Rego, Baldini, Simone, Scartoni, Simona, Simonelli, Cecilia, Capriati, Angela, Maggi, Carlo Alberto, and Florence, Study Grp

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