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2. Antibacterial Therapeutic Ions Incorporation into Bioactive Glasses as a Winning Strategy against Antibiotic Resistance.

Author

Elahpour, Nafise, Niesner, Isabella, Abdellaoui, Nora, Holzapfel, Boris Michael, Gritsch, Lukas, Jallot, Edouard, Mayer‐Wagner, Susanne, and Lao, Jonathan

Subjects
BIOACTIVE glasses, DRUG resistance in bacteria, DRUG resistance in microorganisms, BACTERIAL diseases, METAL ions
Abstract

This work focuses on combating bacterial infections in bone tissue using metal elements embedded in bioactive glass. While there is an urgent need for alternative methods with a shrinking number of effective treatment options untouched by antimicrobial resistance, it is crucial to first understand the mechanisms of pathogenesis, persistence, and bacterial resistance in skeletal infection, and then develop effective counterstrategies and innovative alternatives. This review considers the role of antimicrobial metal ions, their mechanism of action, and their incorporation into bioactive glass formulations as these materials can serve as delivery platforms with the least possible complexities. Furthermore, the bacterial infection risk in bone is also examined with specific attention to antibiotic resistance and biofilm formation. This review sheds light on the most promising materials as novel antibacterial agents by presenting a wide range of possible bioactive glass formulations equipped with potential antibacterial ions and in vitro/ in vivo insights, and it also reinforces the importance of continuing studies to develop multi‐faceted antibacterial bioactive glasses. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Investigation and characterization of the additive manufacturing of polycaprolactone/bioactive glass hybrid scaffolds for bone tissue engineering via material extrusion processing

Author

Gritsch, Lukas, primary, Askanian, Haroutioun, additional, Bednarzig, Vera, additional, Schrüfer, Stefan, additional, Kaschta, Joachim, additional, Blavignac, Christelle, additional, Peuble, Steve, additional, Gallice, Frederic, additional, Jallot, Edouard, additional, Boccaccini, Aldo R., additional, and Lao, Jonathan, additional

Published
2023
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4. Zinc-Doped Bioactive Glass/Polycaprolactone Hybrid Scaffolds Manufactured by Direct and Indirect 3D Printing Methods for Bone Regeneration

Author

Elahpour, Nafise, primary, Niesner, Isabella, additional, Bossard, Cédric, additional, Abdellaoui, Nora, additional, Montouillout, Valérie, additional, Fayon, Franck, additional, Taviot-Guého, Christine, additional, Frankenbach, Tina, additional, Crispin, Alexander, additional, Khosravani, Pardis, additional, Holzapfel, Boris Michael, additional, Jallot, Edouard, additional, Mayer-Wagner, Susanne, additional, and Lao, Jonathan, additional

Published
2023
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11. Polycaprolactone-bioactive glass hybrids as a controlled release platform for the delivery of therapeutics in bone tissue engineering

Author

Gritsch, Lukas, Bossard, Cédric, Forestier, Christiane, Jallot, Edouard, Granel, Henri, Wittrant, Y., Lao, Jonathan, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine (UNH), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Clermont Auvergne (UCA)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2021

13. Polycaprolactone / bioactive glass hybrid scaffolds with doping agents

Author

Bossard, Cédric, Granel, Henri, Jallot, Edouard, Guibourt, Hubert, Boccon, Alexandre, Wittrant, Yohann, Lao, Jonathan, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

16. Investigation of calcium incorporation and organic–inorganic covalent linking in bioactive glass–gelatin hybrids

Author

Montouillout, Valerie, Dieudonné, Xavier, Fayon, Franck, Jallot, Edouard, Lao, Jonathan, Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), and Jallot, Edouard

Subjects
[SDV] Life Sciences [q-bio], [PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Abstract

International audience

Published
2017

18. Implant with controlled porosity made of a hybrid material doped with osteoinductor nutrients

Author

Lao, Jonathan, Jallot, Edouard, Wittrant, Yohann, Granel, Henri, Bossard, Cédric, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), and Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences
Published
2018

19. Polycaprolactone / bioactive glass hybrid scaffolds with controlled porosity

Author

Bossard, C, Granel, Henri, Jallot, Edouard, Fayon, F, Montouillout, Valerie, Drouet, Christophe, Soulié, Jérémy, Wittrant, Y., Lao, J, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Centre interuniversitaire de recherche et d'ingenierie des matériaux (CIRIMAT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences
Abstract

International audience; Inorganic-organic hybrids appear as promising bone substitutes since they associate the bone mineral forming ability of bioactive glasses (BG) with the toughness of polymers. In such hybrids, the main challenge concerns the incorporation of calcium into the BG silicate network, which plays a major role in biomineralisation. Hybrids comprised of polycaprolactone (PCL, M n = 80,000 g/mol) and SiO 2-CaO BG were produced by a sol-gel process and built into porous scaffolds with controlled pore and interconnection sizes. PCL was chosen as the polymer because its slow degradation in vivo makes it a suitable candidate for bone filling. The calcium incorporation, apatite-forming ability, mechanical properties and degradation rate of the hybrid scaffolds were evaluated.

Published
2018

20. Organic-inorganic hybrid scaffold for bone regeneration

Author

Granel, Henri, Bossard, Cédric, Wauquier, F., Rochefort, Gael y, Jallot, Edouard, Lao, Jonathan, Wittrant, Y., Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), and Université Paris Descartes - Paris 5 (UPD5)

Subjects
[SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018

22. Optimized Bioactive Glass: the Quest for the Bony Graft

Author

Granel, Henri, primary, Bossard, Cédric, additional, Nucke, Lisa, additional, Wauquier, Fabien, additional, Rochefort, Gael Y., additional, Guicheux, Jérôme, additional, Jallot, Edouard, additional, Lao, Jonathan, additional, and Wittrant, Yohann, additional

Published
2019
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23. An innovative sol-gel based hybrid biomaterial for bone tissue engineering

Author

Granel, Henri, Bossard, C., Wauquier, Fabien, Collignon, Anne-Marie, rochefort, g.y., Jallot, Edouard, Lao, J, Wittrant, Yohann, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire de Physique de Clermont (LPC), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Pathologies, Imagerie et Biothérapies oro-faciales (EA 2496), Université Paris Descartes - Paris 5 (UPD5), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Acknowledgments: Région Auvergne-Rhône-Alpes, Fonds Européens de développement régional (FEDER), Lotfi Slimani, Plateforme de Micro-CT EA2496 Montrouge, Brigitte Gaillard-Martinie, Plateau Technique de Microscopie Centre INRA ARA (UMR 454 MEDIS) Acknowledgments: Région Auvergne-Rhône-Alpes, Fonds Européens de développement régional (FEDER), Lotfi Slimani, Plateforme de Micro-CT EA2496 Montrouge, Brigitte Gaillard-Martinie, Plateau Technique de Microscopie Centre INRA ARA (UMR 454 MEDIS)Acknowledgments: Région Auvergne-Rhône-Alpes, Fonds Européens de développement régional (FEDER), Lotfi Slimani, Plateforme de Micro-CT EA2496 Montrouge, Brigitte Gaillard-Martinie, Plateau Technique de Microscopie Centre INRA ARA (UMR 454 MEDIS); “An innovative sol-gel based hybrid biomaterial for bone tissue engineering”. Les 20. JFBTM journées Françaises de Biologie des Tissus Minéralisés

Published
2018

24. Multimodal analysis of biomaterials for bone regeneration : IBA to study mineralization and trace elements at the bone interface

Author

Lao, Jonathan, Dieudonné, Xavier, Lacroix, Joséphine, Bossard, Cédric, Jallot, Edouard, Laboratoire de Physique de Clermont (LPC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2018

25. Polycaprolactone / bioactive glass hybrid scaffolds with controlled porosity

Author

Bossard, Cédric, Jallot, Edouard, Lao, Jonathan, Laboratoire de Physique de Clermont (LPC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2017

26. Enhanced Loading and Controlled Delivery of TGF and VEGF with Mesoporous Calcium phosphates Bone Substitutes

Author

Moeller-Siegert, Janina, Parmentier, J., Laquerriere, Patrice, Ouadi, Ali, Raissle, Olivier, Jallot, Edouard, Nedelec, J.M., Vix-Guterl, Cathie, Anselme, Karine, Département de Radiobiologie, Hadronthérapie et Imagerie Moléculaire (DRHIM-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Institut de Science des Matériaux de Mulhouse (IS2M), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), and univOAK, Archive ouverte

Subjects
[CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract

Enhanced Loading and Controlled Delivery of TGF and VEGF with Mesoporous Calcium phosphates Bone Substitutes

Published
2017

27. Light element analysis using the microbeam at AIFIRA facility

Author

Sorieul, Stéphanie, Dieudonné, Xavier, Lao, Jonathan, Jallot, Edouard, Moretto, Philippe, Jallot, Edouard, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Abstract

International audience

Published
2014

29. Bioactive glass hybrid scaffolds with well-controlled and opened porosity: Gelatin/SiO2-CaO System

Author

Dieudonné, Xavier, Montouillout, Valerie, Fayon, Franck, Jallot, Edouard, Lao, Jonathan, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Jallot, Edouard

Subjects
[SDV] Life Sciences [q-bio], [PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Abstract

International audience

Published
2013

30. New process for the synthesis of bioactive glass foams and PIXE study of their behavior in SBF

Author

Lacroix, Joséphine, Lao, Jonathan, Nedelec, J.M., Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), and Jallot, Edouard

Subjects
[SDV] Life Sciences [q-bio], [PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, [PHYS] Physics [physics]
Abstract

International audience

Published
2013

32. Micro PIXE-RBS for the study of Sr release at bioactive glass scaffolds / biological medium interface

Author

Lacroix, Joséphine, Lao, Jonathan, Nedelec, Jean-Marie, Jallot, Edouard, Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), and Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA)

Subjects
[PHYS]Physics [physics], inorganic chemicals, musculoskeletal diseases, Sol-gel, [SDV]Life Sciences [q-bio], PIXE-RBS, [PHYS] Physics [physics], Scaffold, [SDV] Life Sciences [q-bio], Strontium, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, Bioactive glass, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; Strontium is a very interesting element in bone regeneration as it can promote bone formation and limit bone resorption. Bone tissue engineering has a very high potential as a method for bone healing and it requires a 3D macroporous scaffold to serve as a support for cell growth. In that purpose, strontium containing bioactive glass foams made with the sol-gel foaming process are very promising scaffolds as they combine the high bioactivity of bioactive glasses, the beneficial effects of strontium on bone growth and a structure that would allow cell adhesion, cell invasion and vascularization. This paper reports the synthesis of such a material and its in vitro bioactivity study. The release of strontium ions from the material to the biological medium occurs quickly, as shown by ICP-AES results, with the delivery of quantities of Sr ions that should be adequate for bone regeneration. Ion microbeam techniques evidence a very specific behavior of strontium: it is rapidly removed from the inner part of the material but remains in the calcium phosphate layer that is deposited on the surface of the foam pores. It reveals the particular behavior of glass foams compared to other materials suitable for implantation like glass powders of same composition and highlights the interest of ion microbeam techniques in the study of strontium-containing bioactive glass scaffolds.

Published
2012

33. In vitro and in vivo evaluation of the inflammatory potential of various nanoporous calcium phosphate biomaterials

Author

Velard, Frédéric, Schlaubitz, Silke, Fricain, Jean-Christophe, Guillaume, Christine, Laurent-Maquin, Dominique, Möller-Siegert, Janina, Vidal, Loïc, Jallot, Edouard, Sayen, Stéphanie, Raissle, Olivier, Nedelec, J.-M., Vix-Guterl, Cathie, Anselme, Karine, Amédée, Joëlle, Laquerrière, Patrice, Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), INSERM UMR-S1026, Bioingénierie Tissulaire, Université Bordeaux, CHU Bordeaux [Bordeaux], Institut de Science des Matériaux de Mulhouse (IS2M), Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire de Reims - UMR 7312 (ICMR), SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Institut de Chimie du CNRS (INC)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-SFR Condorcet, Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS)-Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), and Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
nanoporous hydroxyapatite biomaterials, inflammatory potential, [CHIM]Chemical Sciences
Abstract

International audience; Aim: To discriminate the most important physicochemical parameters for bone reconstruction, the inflammatory potential of seven nanoporous hydroxyapatite powders synthesized by hard or soft templating was evaluated both in vitro and in vivo. Materials & methods: After physical and chemical characterization of the powders, we studied the production of inflammatory mediators by human primary monocytes after 4 and 24 h in contact with powders, and the host response after 2 weeks implantation in a mouse critical size defect model. Results: In vitro results highlighted increases in the secretion of TNF-α, IL-1, -8, -10 and proMMP-2 and -9 and decreases in the secretion of IL-6 only for powders prepared by hard templating. In vivo observations confirmed an extensive inflammatory tissue reaction and a strong resorption for the most inflammatory powder in vitro. Conclusion: These findings highlight that the most critical physicochemical parameters for these nanoporous hydroxyapatite are, the crystallinity that controls dissolution potential, the specific surface area and the size and shape of crystallites.

Published
2015
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34. Hybrid material implant having variable porosity

Author

Lao, Jonathan, Jallot, Edouard, Dieudonné, Xavier, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences
Published
2014

35. Chemical imaging of bone regeneration induced by bioactive glass implants in vivo: a multimodal and quantitative micro-ion beam analysis of mineralization and trace elements at the bone interface

Author

Lao, Jonathan, Lacroix, Joséphine, Nohra, Johnny, N., Naaman, Sautier, J.-M., Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche des Cordeliers (CRC (UMR_S 872)), and Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

36. Implant with controlled porosity comprising a matrix covered by a bioactive glass or by a hybrid material

Author

Lao, Jonathan, Jallot, Edouard, Dieudonné, Xavier, Lacroix, Joséphine, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences
Published
2014

37. Bioactive glass hybrid scaffolds with well-controlled and opened porosity:Gelatin/SiO2-CaO System

Author

Montouillout, Valerie, Dieudonné, Xavier, Fayon, Franck, Jallot, Edouard, Lao, Jonathan, Conditions Extrêmes et Matériaux : Haute Température et Irradiation (CEMHTI), Université d'Orléans (UO)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

39. Bioavailability of strontium ions from bioactive glasses in vivo: a micro-PIXE study of trace elements at the bone interface

Author

Lao, Jonathan, Lacroix, Joséphine, Nohra, Johnny, N., Naaman, Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2013

40. Implant with controlled porosity made of a hybrid material

Author

Lao, Jonathan, Jallot, Edouard, Dieudonné, Xavier, Lacroix, Joséphine, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences
Published
2013

41. 3D Organized Macroporous Bioactive Glasses: a Study of Pore Size Effect on Physicochemical Reactivity by Micro-PIXE-RBS

Author

Soulié, Jeremy, Hardy-Dessources, Adeline, Nedelec, Jean-Marie, Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-SIGMA Clermont (SIGMA Clermont)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Centre National de la Recherche Scientifique (CNRS), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Abstract

International audience; Macroporous biomaterials have attracted much attention during the past decade because of the large range of associated applications (from drug delivery to tissue engineering). The present study focuses on the correlations between macropore size (from 400 to 1500 nm in diameter) and the early steps of biomineralization process and the reactivity in binary (SiO2-CaO) and ternary (SiO2-CaO-P2O5) bioactive glasses. Macrostructured glasses were elaborated by combining sol-gel chemistry and an inverse opal method with polystyrene beads colloidal crystals as the template. Macroporosity of these materials has been characterized thanks to thermoporosimetry. The in vitro biomineralization process was studied using particle-induced X-ray emission (PIXE) associated with Rutherford backscattering spectrometry (RBS), which are efficient methods for a highly sensitive multielemental analysis. Thanks to elemental maps of silicon, calcium, and phosphorus obtained at a micrometer scale for various interaction times, we demonstrate that the physicochemical reactions are sensitive to macropore size, even though their kinetic is not modified. This key result is an important step to build tunable biomaterials with a highly reproducible and finely controlled response for an optimized integration in living organisms.

Published
2013

42. Quantitative chemical mapping by micro-ion beam of mineralization at bioactive glass scaffolds /biological medium interface

Author

Lacroix, Joséphine, Lao, Jonathan, Nedelec, J.-M., Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de Clermont-Ferrand (ICCF), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), and Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA)

Subjects
[PHYS]Physics [physics], [SDV]Life Sciences [q-bio], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

43. Effect of strontium substituted hydroxyapatite on inflammatory mediator production by human monocytes

Author

Buache, Emilie, Velard, F., Bauden, E., Guillaume, C., Jallot, Edouard, Nedelec, Jean-Marie, Laurent-Maquin, D., Laquerriere, P., Biomatériaux et inflammation en site osseux - EA 4691 (BIOS), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), MI, Institut de Chimie de Clermont-Ferrand (ICCF), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Bonnefoy, Stéphanie

Subjects
Calcium phosphate Cytokines Inflammation Strontium Matrix metalloproteinases
Abstract

International audience; Calcium phosphate materials are widely used as bone substitutes because of their properties close to those of the mineral phase of bones. Nevertheless, after several months, calcium phosphate-based materials release particles that may be phagocytosed by monocytes, leading to an inflammatory reaction. Strontium is well known to counteract the osteoporosis process, but little is known about its effect on inflammatory processes. The purpose of this work was to study the effect of biphasic calcium phosphate (BCP) particles substituted with strontium on the inflammatory reaction. Human primary monocytes stimulated or not by lipopolysaccharide (LPS) were exposed to BCP particles containing strontium for 6 and 24 h. Inflammatory mediators (cytokines and matrix metalloproteinases (MMPs)) production was then quantified by ELISA and zymography. We observed that the presence of strontium had few effects on unstimulated cells, but it decreased the production of pro-inflammatory cytokines and the chemokine interleukin 8 in LPS-stimulated cell-conditioned medium. This work suggests for the first time that strontium may be involved in the control of inflammatory processes following BCP phagocytosis by human monocytes.

Published
2012

44. Micro-Ion beam analysis highlighting the effect of porosity in bioactive glass scaffolds for bone tissue engineering

Author

Lacroix, Joséphine, Lao, Jonathan, Nedelec, Jean-Marie, Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux Inorganiques (LMI), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Clermont Université-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Pellet, Jeanine

Subjects
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials, [CHIM.MATE] Chemical Sciences/Material chemistry, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], micro-ion beam, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], bioactive glass, [CHIM.MATE]Chemical Sciences/Material chemistry, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Published
2011

45. Quantitative Chemical Mapping by Micro- and Nano- Ion Beams of Biomaterials/Biological Medium Interfaces

Author

Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], ion beam, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Abstract

The underlying concepts of biocompatibility, biomimetism, and bioactivity make the interface between biomaterials and biological medium a privileged zone of interest. This talk will give an exhaustive view of how ion beams techniques can contribute to a better understanding of such interface, taking several examples dealing with bone tissue substitution. Knowledge of the elemental distribution of the local concentration and chemical nature of ions at the biomaterials/living tissues interface is primordial to understand the complex interfacial reactions and physico-chemical properties of materials involved during the material integration, biomimetism processes, and bone bonding. Moreover, quantitative chemical mapping of relevant bone trace elements can permit improvement in the quality and above all the functionality of these biomaterials. These elements released in trace quantities physiologically interesting can induce specific cellular responses. Thus, it is important to study at the micrometer and nanometer scale interfaces that biomaterials develop in vitro and in vivo. Ion beam methods of analysis like PIXE, RBS, and STIM are very useful to determine simultaneously multielemental maps and concentration measurements of major, minor, and trace elements with a good spatial resolution. Thanks to the last instrumental developments of accelerators, ion beams from micrometer to nanometer are obtained.

Published
2011

46. Nanoporous calcium phosphates as vectors for proteins :a PIXE-RBS analysis for spatially resolved quantitative chemical imaging

Author

Raissle, O., Soulie, J., Möller, J., Anselme, K., Jallot, Edouard, Nedelec, Jean-Marie, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux Inorganiques (LMI), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Clermont Université-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de chimie des surfaces et interfaces de Mulhouse (ICSIM), Ecole Nationale Supérieure de Chimie de Mulhouse-Centre National de la Recherche Scientifique (CNRS), Pellet, Jeanine, Institut de Chimie et des Surfaces et Interfaces (ICSI), and Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials, [CHIM.MATE] Chemical Sciences/Material chemistry, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [CHIM.MATE]Chemical Sciences/Material chemistry, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2011

47. Fine tuning of bioactivity of bioceramics through porosity engineering: a soft chemistry approach

Author

Soulié, J., Lao, Jonathan, Jallot, Edouard, Nedelec, Jean-Marie, Pellet, Jeanine, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux Inorganiques (LMI), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Clermont Université-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.IB] Life Sciences [q-bio]/Bioengineering, [CHIM.MATE] Chemical Sciences/Material chemistry, [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], bioceramic, bioactivity, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [SDV.IB]Life Sciences [q-bio]/Bioengineering, [CHIM.MATE]Chemical Sciences/Material chemistry
Abstract

When bioactive glasses are in contact with living tissues, several physico-chemical reactions take place at the material/bone interface, and lead to the formation of a phosphocalcic layer whose composition is close to the mineral phase of bone (hydroxyapatite). This layer is used as a mineralization site for cells and finally allows an intimate bond between the bioactive glass and osseous tissues. This binding is typical of bioactivity, which can be modulated through several parameters of the glass, like composition and textural properties. In this work we present clear evidence of the effect of porosity on the bioactivity of sol-gel derived glasses. Using templating techniques (surfactants and polystren beads respectively), both mesostructured and organized macroporous glasses have been prepared. A nice 3D organization of pores is observed for all glasses by using X-ray diffraction and TEM. Textural properties have been determined using gas sorption and themoporosimetry. Interactions between biological medium and the different glasses have been studied for different delays. At each time period, quantitative chemical maps of samples were recorded by Particle Induced X-ray Emission coupled to Rutherford Backscattering spectroscopy. This technique allows monitoring spatial and chronological evolutions of elemental concentrations, thanks to the excellent sensitivity. The influence of porosity on the bioactivity has been determined and key parameters have been determined.

Published
2011

49. Biomatériaux - Imagerie chimique quantitative par micro- et nano -faisceaux d'ions

Author

Jallot, Edouard, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
plateforme AIFIRA, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], biomatériaux, [PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph]
Published
2010

50. Towards a Better Structural Characterization of Substituted Hydroxyapatites

Author

Wang, Y., Nassif, N., Bonhomme, L., Bonhomme, Christian, Babonneau, F., Nedelec, Jean-Marie, Gomes, S., Renaudin, G., Jallot, Edouard, Laboratoire de Chimie de la Matière Condensée de Paris (site Paris VI) (LCMCP (site Paris VI)), Université Pierre et Marie Curie - Paris 6 (UPMC)-Collège de France (CdF (institution))-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Matériaux Inorganiques (LMI), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Clermont Université-SIGMA Clermont (SIGMA Clermont)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), and Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [CHIM.MATE]Chemical Sciences/Material chemistry, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials
Abstract

International audience; The richness of the apatite structure is an extraordinary ability to accept substitutions and vacancies and this property is intimately related to its adaptability to the biological functions of different tissues. The apatite structure can incorporate a wide variety of ions, of the same or of different charge, which affect both its cationic and anionic sub-lattices. If necessary, charge compensation can be achieved through the combination of ions of different charges and/or through the creation of vacancies, leading to apatites with complex formulae. This presentation will illustrate how multinuclear solid state NMR methods can be efficiently used to describe the local environment of carbonates and silicates in substituted hydroxyapatites, HAp. Two examples will be presented : silicon- substituted biphasic calcium phosphate bioceramics and carbonated hydroxyapatite layer grown on sol-gel glass soaked in SBF.

Published
2010

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