1. Chemotherapy-Induced Peripheral Neuropathy (CIPN): A Narrative Review and Proposed Theoretical Model.
- Author
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Lee, Kimberley T., Bulls, Hailey W., Hoogland, Aasha I., James, Brian W., Colon-Echevarria, Claudia B., and Jim, Heather S. L.
- Subjects
PERIPHERAL neuropathy ,PRESUMPTIONS (Law) ,SEDENTARY lifestyles ,CANCER chemotherapy ,MATHEMATICAL models ,THEORY ,HEALTH outcome assessment ,HEALTH care teams ,DEMOGRAPHY ,GENETICS ,COMORBIDITY ,MENTAL depression - Abstract
Simple Summary: This article outlines a framework for the development and maintenance of chemotherapy-induced peripheral neuropathy using the 3P model, which focuses on predisposing, precipitating, and perpetuating factors. Predisposing factors increase the risk of CIPN onset; chemotherapy triggers the development of CIPN; and perpetuating factors maintain CIPN and limit recovery, such that CIPN becomes a chronic condition. In our proposed model, we have identified demographic, genetic, and clinical factors, such as comorbidities, as predisposing factors. Chemotherapy type, dose, and schedule are precipitating factors. Perpetuating factors include depression and physical activity. The proposed model can be used to identify treatment targets for the management of chemotherapy-induced peripheral neuropathy. Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and debilitating symptom experienced by cancer survivors. Despite the burden of CIPN-related symptoms, interventions remain limited. Objectives: This narrative review seeks to propose a framework for CIPN predisposing, precipitating, and perpetuating factors (3Ps), which will provide a foundation for future research and clinical interventions aimed at mitigating CIPN-related symptoms and morbidity. Methods: A comprehensive literature search was performed using PubMed, guided by keywords related to "chemotherapy-induced peripheral neuropathy." Studies were limited to those with full text available in English. Results: Predisposing factors outlined in this framework, such as older age and comorbid conditions, can be used to identify patients who have a higher risk of developing CIPN. The major precipitating factor of CIPN is the delivery of chemotherapy to peripheral nerves, which may be mitigated via cryotherapy or compression therapy during chemotherapy. Perpetuating factors can offer insight into psychological, cognitive, and behavioral modifications that could be treatment targets for CIPN management. Conclusion: The proposed 3P model can guide the development of effective interventions for CIPN by suggesting modifiable psychological and behavioral treatment targets that may mitigate the impact of CIPN for cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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